47853:HXZ27 RS16890
gene id: 47853:HXZ27_RS16890
uniprot id: A0A1C4VNW8
names: Similarity
messages: Belongs to the CsoR family.

47853:HXZ27 RS22935
gene id: 47853:HXZ27_RS22935
uniprot id: A0A7H8XWI6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

47853:HXZ27 RS09885
gene id: 47853:HXZ27_RS09885
uniprot id: A0A1C5AXF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

47853:HXZ27 RS07405
gene id: 47853:HXZ27_RS07405
uniprot id: A0A1C4W5D7
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

47853:HXZ27 RS07870
gene id: 47853:HXZ27_RS07870
uniprot id: A0A1C4W915
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

47853:HXZ27 RS00390
gene id: 47853:HXZ27_RS00390
uniprot id: A0A1C4Z7W5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47853:HXZ27 RS21720
gene id: 47853:HXZ27_RS21720
uniprot id: A0A1C4X6G8
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

47853:HXZ27 RS01995
gene id: 47853:HXZ27_RS01995
uniprot id: A0A1C4YXX3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

47853:HXZ27 RS06480
gene id: 47853:HXZ27_RS06480
uniprot id: A0A7H8XJA6
names: Similarity
messages: Belongs to the PGI/PMI family.

47853:HXZ27 RS21975
gene id: 47853:HXZ27_RS21975
uniprot id: A0A1C4X920
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

47853:HXZ27 RS08325
gene id: 47853:HXZ27_RS08325
uniprot id: A0A1C4WCS7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47853:HXZ27 RS24670
gene id: 47853:HXZ27_RS24670
uniprot id: A0A1C4XMW9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

47853:HXZ27 RS30065
gene id: 47853:HXZ27_RS30065
uniprot id: A0A1C4Y8K8
names: Similarity
messages: Belongs to the cytochrome P450 family.

47853:HXZ27 RS22200
gene id: 47853:HXZ27_RS22200
uniprot id: A0A1C4XBC9
names: Subcellular Location Annotation
messages: Membrane

47853:HXZ27 RS10540
gene id: 47853:HXZ27_RS10540
uniprot id: A0A1C4ZC48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

47853:HXZ27 RS26310
gene id: 47853:HXZ27_RS26310
uniprot id: A0A1C4USK4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

47853:HXZ27 RS01775
gene id: 47853:HXZ27_RS01775
uniprot id: A0A1C4YZC2
names: Similarity
messages: Belongs to the peptidase C40 family.

47853:HXZ27 RS08010
gene id: 47853:HXZ27_RS08010
uniprot id: A0A1C4WAC8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

47853:HXZ27 RS09810
gene id: 47853:HXZ27_RS09810
uniprot id: A0A1C5AX62
names: Similarity
messages: Belongs to the universal stress protein A family.

47853:HXZ27 RS25475
gene id: 47853:HXZ27_RS25475
uniprot id: A0A1C5AKX0
names: Similarity
messages: Belongs to the peptidase C40 family.

47853:HXZ27 RS26800
gene id: 47853:HXZ27_RS26800
uniprot id: A0A1C4UMD8
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

47853:HXZ27 RS06320
gene id: 47853:HXZ27_RS06320
uniprot id: A0A1C5ARH2
names: Subcellular Location Annotation
messages: Membrane

47853:HXZ27 RS23340
gene id: 47853:HXZ27_RS23340
uniprot id: A0A1C4Y2F0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

47853:HXZ27 RS26860
gene id: 47853:HXZ27_RS26860
uniprot id: A0A1C4ULT6
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

47853:HXZ27 RS09095
gene id: 47853:HXZ27_RS09095
uniprot id: A0A1C4WK86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

47853:HXZ27 RS08660
gene id: 47853:HXZ27_RS08660
uniprot id: A0A1C4WG13
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

47853:HXZ27 RS21865
gene id: 47853:HXZ27_RS21865
uniprot id: A0A1C4X861
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

47853:HXZ27 RS27305
gene id: 47853:HXZ27_RS27305
uniprot id: A0A1C4UI52
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

47853:HXZ27 RS27500
gene id: 47853:HXZ27_RS27500
uniprot id: A0A7H8XR53
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

47853:HXZ27 RS25165
gene id: 47853:HXZ27_RS25165
uniprot id: A0A1C5ALH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Cell membrane

47853:HXZ27 RS27600
gene id: 47853:HXZ27_RS27600
uniprot id: A0A1C4UEZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

47853:HXZ27 RS25915
gene id: 47853:HXZ27_RS25915
uniprot id: A0A1C4UWG3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

47853:HXZ27 RS24980
gene id: 47853:HXZ27_RS24980
uniprot id: A0A1C5AM05
names: Similarity
messages: Belongs to the LacAB/RpiB family.

47853:HXZ27 RS22845
gene id: 47853:HXZ27_RS22845
uniprot id: A0A1C4XHK6
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

47853:HXZ27 RS28590
gene id: 47853:HXZ27_RS28590
uniprot id: A0A1C4U504
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

47853:HXZ27 RS04200
gene id: 47853:HXZ27_RS04200
uniprot id: A0A1C5AEK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

47853:HXZ27 RS27515
gene id: 47853:HXZ27_RS27515
uniprot id: A0A1C4UFW3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

47853:HXZ27 RS20290
gene id: 47853:HXZ27_RS20290
uniprot id: A0A7H8XXJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

47853:HXZ27 RS06535
gene id: 47853:HXZ27_RS06535
uniprot id: A0A7H8XFU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

47853:HXZ27 RS06510
gene id: 47853:HXZ27_RS06510
uniprot id: A0A1C5ARQ1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DyP-type peroxidase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.
messages: Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact.

47853:HXZ27 RS22670
gene id: 47853:HXZ27_RS22670
uniprot id: A0A1C4XGC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

47853:HXZ27 RS08545
gene id: 47853:HXZ27_RS08545
uniprot id: A0A1C4WF32
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

47853:HXZ27 RS07970
gene id: 47853:HXZ27_RS07970
uniprot id: A0A1C4WA42
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

47853:HXZ27 RS04100
gene id: 47853:HXZ27_RS04100
uniprot id: A0A7H8XTI0
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47853:HXZ27 RS11135
gene id: 47853:HXZ27_RS11135
uniprot id: A0A1C4ZG21
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

47853:HXZ27 RS13205
gene id: 47853:HXZ27_RS13205
uniprot id: A0A1C5AP73
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

47853:HXZ27 RS25025
gene id: 47853:HXZ27_RS25025
uniprot id: A0A1C5ALT9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 3-HAO family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.

47853:HXZ27 RS27640
gene id: 47853:HXZ27_RS27640
uniprot id: A0A1C4UEN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

47853:HXZ27 RS27360
gene id: 47853:HXZ27_RS27360
uniprot id: A0A1C4UHH4
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

47853:HXZ27 RS18415
gene id: 47853:HXZ27_RS18415
uniprot id: A0A1C5AJ96
names: Subcellular Location Annotation
messages: Membrane

47853:HXZ27 RS05745
gene id: 47853:HXZ27_RS05745
uniprot id: A0A1C5A479
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

47853:HXZ27 RS07940
gene id: 47853:HXZ27_RS07940
uniprot id: A0A1C4W9R3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

47853:HXZ27 RS27570
gene id: 47853:HXZ27_RS27570
uniprot id: A0A1C4UFD4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

47853:HXZ27 RS27230
gene id: 47853:HXZ27_RS27230
uniprot id: A0A1C4UIS1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

47853:HXZ27 RS27555
gene id: 47853:HXZ27_RS27555
uniprot id: A0A1C4UFF0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

47853:HXZ27 RS29195
gene id: 47853:HXZ27_RS29195
uniprot id: A0A1C4TZU3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47853:HXZ27 RS29755
gene id: 47853:HXZ27_RS29755
uniprot id: A0A1C4TWC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

47853:HXZ27 RS22885
gene id: 47853:HXZ27_RS22885
uniprot id: A0A1C4Y742
names: Cofactor
names: Similarity
messages: Belongs to the class-II DAHP synthase family.
messages: Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.

47853:HXZ27 RS09415
gene id: 47853:HXZ27_RS09415
uniprot id: A0A1C4WNB5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ChdC family. Type 2 subfamily.
messages: Fe-coproporphyrin III acts as both substrate and redox cofactor.
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway. The reaction occurs in a stepwise manner with a three-propionate intermediate.

47853:HXZ27 RS17220
gene id: 47853:HXZ27_RS17220
uniprot id: A0A1C4VRY3
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

47853:HXZ27 RS00375
gene id: 47853:HXZ27_RS00375
uniprot id: A0A1C4Z7F7
names: Subcellular Location Annotation
messages: Membrane

47853:HXZ27 RS05085
gene id: 47853:HXZ27_RS05085
uniprot id: A0A1C5A6W2
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

47853:HXZ27 RS00015
gene id: 47853:HXZ27_RS00015
uniprot id: A0A1C5AR26
names: Similarity
messages: Belongs to the 6-phosphogluconate dehydrogenase family.

47853:HXZ27 RS29260
gene id: 47853:HXZ27_RS29260
uniprot id: A0A1C4TZL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

47853:HXZ27 RS27180
gene id: 47853:HXZ27_RS27180
uniprot id: A0A7D5YC03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

47853:HXZ27 RS29420
gene id: 47853:HXZ27_RS29420
uniprot id: A0A7H8XS51
names: Subcellular Location Annotation
messages: Membrane

47853:HXZ27 RS23400
gene id: 47853:HXZ27_RS23400
uniprot id: A0A1C4Y1R9
names: Similarity
messages: Belongs to the glutamine synthetase family.

47853:HXZ27 RS21535
gene id: 47853:HXZ27_RS21535
uniprot id: A0A1C4X502
names: Similarity
messages: Belongs to the band 7/mec-2 family.

47853:HXZ27 RS20535
gene id: 47853:HXZ27_RS20535
uniprot id: A0A1C5AT00
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

47853:HXZ27 RS24710
gene id: 47853:HXZ27_RS24710
uniprot id: A0A7H8XQC8
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

47853:HXZ27 RS11610
gene id: 47853:HXZ27_RS11610
uniprot id: A0A1C4ZJ99
names: Subcellular Location Annotation
messages: Cytoplasm

47853:HXZ27 RS19505
gene id: 47853:HXZ27_RS19505
uniprot id: A0A1C4ZXT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sbp family.
messages: Cell membrane

47853:HXZ27 RS12155
gene id: 47853:HXZ27_RS12155
uniprot id: A0A1C5ATN4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

47853:HXZ27 RS28720
gene id: 47853:HXZ27_RS28720
uniprot id: A0A1C4U3M4
names: Subcellular Location Annotation
messages: Cytoplasm

47853:HXZ27 RS25760
gene id: 47853:HXZ27_RS25760
uniprot id: A0A1C5AKC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

47853:HXZ27 RS27610
gene id: 47853:HXZ27_RS27610
uniprot id: A0A1C4UF01
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

47853:HXZ27 RS05230
gene id: 47853:HXZ27_RS05230
uniprot id: A0A7H8XG79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

47853:HXZ27 RS08120
gene id: 47853:HXZ27_RS08120
uniprot id: A0A1C4WBT6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

47853:HXZ27 RS29155
gene id: 47853:HXZ27_RS29155
uniprot id: A0A7H8XVH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DisA family.
messages: Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
messages: Homooctamer.
messages: Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions.

47853:HXZ27 RS23035
gene id: 47853:HXZ27_RS23035
uniprot id: A0A1C4Y5Q0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

47853:HXZ27 RS08750
gene id: 47853:HXZ27_RS08750
uniprot id: A0A1C4WGV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

47853:HXZ27 RS27655
gene id: 47853:HXZ27_RS27655
uniprot id: A0A1C4UEF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

47853:HXZ27 RS17240
gene id: 47853:HXZ27_RS17240
uniprot id: A0A1C4VRQ1
names: Similarity
messages: Belongs to the OsmC/Ohr family.

47853:HXZ27 RS28410
gene id: 47853:HXZ27_RS28410
uniprot id: A0A1C4U782
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

47853:HXZ27 RS19380
gene id: 47853:HXZ27_RS19380
uniprot id: A0A1C4ZXB3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

47853:HXZ27 RS22425
gene id: 47853:HXZ27_RS22425
uniprot id: A0A1C4XE70
names: Similarity
messages: Belongs to the TrpC family.

47853:HXZ27 RS08440
gene id: 47853:HXZ27_RS08440
uniprot id: A0A1C4WDZ6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

47853:HXZ27 RS21090
gene id: 47853:HXZ27_RS21090
uniprot id: A0A1C4WVX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

47853:HXZ27 RS31485
gene id: 47853:HXZ27_RS31485
uniprot id: A0A1C5AR66
names: Subcellular Location Annotation
messages: Membrane

47853:HXZ27 RS27940
gene id: 47853:HXZ27_RS27940
uniprot id: A0A1C4UBQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

47853:HXZ27 RS28200
gene id: 47853:HXZ27_RS28200
uniprot id: A0A1C4U9E2
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

47853:HXZ27 RS27605
gene id: 47853:HXZ27_RS27605
uniprot id: A0A1C4UEZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

47853:HXZ27 RS27210
gene id: 47853:HXZ27_RS27210
uniprot id: A0A1C4UJ27
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

47853:HXZ27 RS30835
gene id: 47853:HXZ27_RS30835
uniprot id: A0A1C5AVY7
names: Subcellular Location Annotation
messages: Membrane

47853:HXZ27 RS24560
gene id: 47853:HXZ27_RS24560
uniprot id: A0A1C4XQA1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

47853:HXZ27 RS22635
gene id: 47853:HXZ27_RS22635
uniprot id: A0A1C4XFP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

47853:HXZ27 RS23395
gene id: 47853:HXZ27_RS23395
uniprot id: A0A1C4Y2U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0719 family.
messages: Membrane

47853:HXZ27 RS11930
gene id: 47853:HXZ27_RS11930
uniprot id: A0A1C5ATS5
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

47853:HXZ27 RS06475
gene id: 47853:HXZ27_RS06475
uniprot id: A0A1C5ARZ3
names: Similarity
messages: Belongs to the UPF0434 family.

47853:HXZ27 RS17510
gene id: 47853:HXZ27_RS17510
uniprot id: A0A1C4VU65
names: Subcellular Location Annotation
messages: Membrane

47853:HXZ27 RS24445
gene id: 47853:HXZ27_RS24445
uniprot id: A0A1C4XQQ3
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

47853:HXZ27 RS04745
gene id: 47853:HXZ27_RS04745
uniprot id: A0A1C5A879
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

47853:HXZ27 RS21835
gene id: 47853:HXZ27_RS21835
uniprot id: A0A1C4X8B3
names: Subcellular Location Annotation
messages: Membrane

47853:HXZ27 RS25925
gene id: 47853:HXZ27_RS25925
uniprot id: A0A7H8XQZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

47853:HXZ27 RS13590
gene id: 47853:HXZ27_RS13590
uniprot id: A0A1C5AWI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

47853:HXZ27 RS28615
gene id: 47853:HXZ27_RS28615
uniprot id: A0A1C4U4R0
names: Subcellular Location Annotation
messages: Membrane

47853:HXZ27 RS06250
gene id: 47853:HXZ27_RS06250
uniprot id: A0A1C5ARA6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

47853:HXZ27 RS27510
gene id: 47853:HXZ27_RS27510
uniprot id: A0A1C4UFX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

47853:HXZ27 RS13715
gene id: 47853:HXZ27_RS13715
uniprot id: A0A1C5AWL5
names: Subcellular Location Annotation
messages: Membrane

47853:HXZ27 RS24630
gene id: 47853:HXZ27_RS24630
uniprot id: A0A7H8XY79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

47853:HXZ27 RS09030
gene id: 47853:HXZ27_RS09030
uniprot id: A0A7H8XHT5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the selenophosphate synthase 1 family. Class I subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Homodimer.
messages: Synthesizes selenophosphate from selenide and ATP.

47853:HXZ27 RS02075
gene id: 47853:HXZ27_RS02075
uniprot id: A0A1C4YX70
names: Similarity
messages: Belongs to the WXG100 family.

47853:HXZ27 RS27625
gene id: 47853:HXZ27_RS27625
uniprot id: A0A1C4UET6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

47853:HXZ27 RS10290
gene id: 47853:HXZ27_RS10290
uniprot id: A0A1C5AV73
names: Subcellular Location Annotation
messages: Membrane

47853:HXZ27 RS05725
gene id: 47853:HXZ27_RS05725
uniprot id: A0A1C5A4L6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

47853:HXZ27 RS26595
gene id: 47853:HXZ27_RS26595
uniprot id: A0A1C4UPL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

47853:HXZ27 RS24885
gene id: 47853:HXZ27_RS24885
uniprot id: A0A1C5AMG3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47853:HXZ27 RS00010
gene id: 47853:HXZ27_RS00010
uniprot id: A0A1C5AQW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

47853:HXZ27 RS31745
gene id: 47853:HXZ27_RS31745
uniprot id: A0A7H8XUU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

47853:HXZ27 RS21485
gene id: 47853:HXZ27_RS21485
uniprot id: A0A1C4X4K7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurD2 subfamily.
messages: Cell wall formation. Catalyzes the addition of L-glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine.
messages: Cytoplasm

47853:HXZ27 RS00315
gene id: 47853:HXZ27_RS00315
uniprot id: A0A1C4Z7V6
names: Subcellular Location Annotation
messages: Membrane

47853:HXZ27 RS13710
gene id: 47853:HXZ27_RS13710
uniprot id: A0A1C5AWM1
names: Subcellular Location Annotation
messages: Membrane

47853:HXZ27 RS20510
gene id: 47853:HXZ27_RS20510
uniprot id: A0A1C5ASR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

47853:HXZ27 RS20360
gene id: 47853:HXZ27_RS20360
uniprot id: A0A1C5ASI6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

47853:HXZ27 RS28840
gene id: 47853:HXZ27_RS28840
uniprot id: A0A1C4U2K1
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

47853:HXZ27 RS21360
gene id: 47853:HXZ27_RS21360
uniprot id: A0A1C4X394
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

47853:HXZ27 RS26690
gene id: 47853:HXZ27_RS26690
uniprot id: A0A1C4UNK9
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

47853:HXZ27 RS05075
gene id: 47853:HXZ27_RS05075
uniprot id: A0A7H8XF29
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

47853:HXZ27 RS21870
gene id: 47853:HXZ27_RS21870
uniprot id: A0A1C4X886
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

47853:HXZ27 RS24435
gene id: 47853:HXZ27_RS24435
uniprot id: A0A1C4XQK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

47853:HXZ27 RS24890
gene id: 47853:HXZ27_RS24890
uniprot id: A0A1C5AN22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

47853:HXZ27 RS04725
gene id: 47853:HXZ27_RS04725
uniprot id: A0A1C5A8H5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47853:HXZ27 RS10695
gene id: 47853:HXZ27_RS10695
uniprot id: A0A1C4ZD86
names: Similarity
messages: Belongs to the polysaccharide synthase family.

47853:HXZ27 RS31735
gene id: 47853:HXZ27_RS31735
uniprot id: A0A1C5AQW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

47853:HXZ27 RS26795
gene id: 47853:HXZ27_RS26795
uniprot id: A0A7H8XTW4
names: Similarity
messages: Belongs to the Nudix hydrolase family.

47853:HXZ27 RS20575
gene id: 47853:HXZ27_RS20575
uniprot id: A0A1C5ASX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

47853:HXZ27 RS21560
gene id: 47853:HXZ27_RS21560
uniprot id: A0A1C4X586
names: Cofactor
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Divalent metal ions. Mg(2+) is the most effective.

47853:HXZ27 RS31685
gene id: 47853:HXZ27_RS31685
uniprot id: A0A1C5AQV5
names: Similarity
messages: Belongs to the thioredoxin family.

47853:HXZ27 RS04770
gene id: 47853:HXZ27_RS04770
uniprot id: A0A1C5A856
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

47853:HXZ27 RS27805
gene id: 47853:HXZ27_RS27805
uniprot id: A0A1C4UD06
names: Similarity
messages: Belongs to the UPF0234 family.

47853:HXZ27 RS27550
gene id: 47853:HXZ27_RS27550
uniprot id: A0A1C4UFJ9
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

47853:HXZ27 RS27735
gene id: 47853:HXZ27_RS27735
uniprot id: A0A1C4UDP9
names: Similarity
messages: Belongs to the UPF0336 family.

47853:HXZ27 RS31550
gene id: 47853:HXZ27_RS31550
uniprot id: A0A1C5AQN0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

47853:HXZ27 RS21930
gene id: 47853:HXZ27_RS21930
uniprot id: A0A1C4X8G6
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47853:HXZ27 RS10760
gene id: 47853:HXZ27_RS10760
uniprot id: A0A1C4ZDZ6
names: Similarity
messages: Belongs to the ABC transporter superfamily.

47853:HXZ27 RS00845
gene id: 47853:HXZ27_RS00845
uniprot id: A0A1C4Z469
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

47853:HXZ27 RS27565
gene id: 47853:HXZ27_RS27565
uniprot id: A0A1C4UFD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

47853:HXZ27 RS09005
gene id: 47853:HXZ27_RS09005
uniprot id: A0A1C4WJH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

47853:HXZ27 RS07070
gene id: 47853:HXZ27_RS07070
uniprot id: A0A1C4W1W7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

47853:HXZ27 RS24770
gene id: 47853:HXZ27_RS24770
uniprot id: A0A1C4XML5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

47853:HXZ27 RS08315
gene id: 47853:HXZ27_RS08315
uniprot id: A0A1C4WCL4
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

47853:HXZ27 RS14865
gene id: 47853:HXZ27_RS14865
uniprot id: A0A1C4ZP82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

47853:HXZ27 RS24895
gene id: 47853:HXZ27_RS24895
uniprot id: A0A1C5AMF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

47853:HXZ27 RS16415
gene id: 47853:HXZ27_RS16415
uniprot id: A0A1C4VID2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

47853:HXZ27 RS01825
gene id: 47853:HXZ27_RS01825
uniprot id: A0A1C4YYV5
names: Subcellular Location Annotation
messages: Membrane

47853:HXZ27 RS12955
gene id: 47853:HXZ27_RS12955
uniprot id: A0A1C5ANS6
names: Similarity
messages: Belongs to the glycosyl hydrolase 27 family.

47853:HXZ27 RS28755
gene id: 47853:HXZ27_RS28755
uniprot id: A0A1C4U3G8
names: Subcellular Location Annotation
messages: Membrane

47853:HXZ27 RS29105
gene id: 47853:HXZ27_RS29105
uniprot id: A0A1C4U0P3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47853:HXZ27 RS17745
gene id: 47853:HXZ27_RS17745
uniprot id: A0A7H8XMF7
names: Similarity
messages: Belongs to the ABC transporter superfamily.

47853:HXZ27 RS29395
gene id: 47853:HXZ27_RS29395
uniprot id: A0A7D6CDT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

47853:HXZ27 RS24765
gene id: 47853:HXZ27_RS24765
uniprot id: A0A1C4XN75
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

47853:HXZ27 RS03590
gene id: 47853:HXZ27_RS03590
uniprot id: A0A1C4YJ09
names: Subcellular Location Annotation
messages: Cytoplasm

47853:HXZ27 RS22970
gene id: 47853:HXZ27_RS22970
uniprot id: A0A1C4Y788
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.

47853:HXZ27 RS23815
gene id: 47853:HXZ27_RS23815
uniprot id: A0A1C4XWS5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

47853:HXZ27 RS31555
gene id: 47853:HXZ27_RS31555
uniprot id: A0A1C5AR40
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

47853:HXZ27 RS27235
gene id: 47853:HXZ27_RS27235
uniprot id: A0A7H8XYD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein bS18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm

47853:HXZ27 RS01965
gene id: 47853:HXZ27_RS01965
uniprot id: A0A1C4YXU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

47853:HXZ27 RS09665
gene id: 47853:HXZ27_RS09665
uniprot id: A0A1C5AWY3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47853:HXZ27 RS25470
gene id: 47853:HXZ27_RS25470
uniprot id: A0A1C5AKW6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

47853:HXZ27 RS27140
gene id: 47853:HXZ27_RS27140
uniprot id: A0A1C4UJK6
names: Similarity
messages: Belongs to the IMPDH/GMPR family.

47853:HXZ27 RS07100
gene id: 47853:HXZ27_RS07100
uniprot id: A0A7H8XJL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

47853:HXZ27 RS26160
gene id: 47853:HXZ27_RS26160
uniprot id: A0A7H8XTL7
names: Similarity
messages: Belongs to the CutA family.

47853:HXZ27 RS10295
gene id: 47853:HXZ27_RS10295
uniprot id: A0A1C5AV46
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47853:HXZ27 RS24650
gene id: 47853:HXZ27_RS24650
uniprot id: A0A1C4XNA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

47853:HXZ27 RS29355
gene id: 47853:HXZ27_RS29355
uniprot id: A0A7H8XUZ2
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

47853:HXZ27 RS24515
gene id: 47853:HXZ27_RS24515
uniprot id: A0A1C4XPS8
names: Subcellular Location Annotation
messages: Membrane

47853:HXZ27 RS05450
gene id: 47853:HXZ27_RS05450
uniprot id: A0A1C5A588
names: Subcellular Location Annotation
messages: Membrane

47853:HXZ27 RS25955
gene id: 47853:HXZ27_RS25955
uniprot id: A0A7H8XVY8
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

47853:HXZ27 RS26525
gene id: 47853:HXZ27_RS26525
uniprot id: A0A1C4UQG9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

47853:HXZ27 RS20485
gene id: 47853:HXZ27_RS20485
uniprot id: A0A1C5AT88
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

47853:HXZ27 RS27300
gene id: 47853:HXZ27_RS27300
uniprot id: A0A1C4UI48
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

47853:HXZ27 RS21295
gene id: 47853:HXZ27_RS21295
uniprot id: A0A1C4X3F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

47853:HXZ27 RS27545
gene id: 47853:HXZ27_RS27545
uniprot id: A0A1C4UFJ2
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

47853:HXZ27 RS29435
gene id: 47853:HXZ27_RS29435
uniprot id: A0A1C4TY87
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

47853:HXZ27 RS02015
gene id: 47853:HXZ27_RS02015
uniprot id: A0A1C4YXS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

47853:HXZ27 RS22700
gene id: 47853:HXZ27_RS22700
uniprot id: A0A1C4XGD7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

47853:HXZ27 RS27595
gene id: 47853:HXZ27_RS27595
uniprot id: A0A7D6CDD8
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

47853:HXZ27 RS11140
gene id: 47853:HXZ27_RS11140
uniprot id: A0A1C4ZGQ2
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

47853:HXZ27 RS15780
gene id: 47853:HXZ27_RS15780
uniprot id: A0A1C4VCC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

47853:HXZ27 RS09260
gene id: 47853:HXZ27_RS09260
uniprot id: A0A1C4WM30
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

47853:HXZ27 RS29110
gene id: 47853:HXZ27_RS29110
uniprot id: A0A1C4U0E7
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

47853:HXZ27 RS27250
gene id: 47853:HXZ27_RS27250
uniprot id: A0A1C4UIJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

47853:HXZ27 RS10095
gene id: 47853:HXZ27_RS10095
uniprot id: A0A1C5AVH7
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

47853:HXZ27 RS07910
gene id: 47853:HXZ27_RS07910
uniprot id: A0A1C4W9E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

47853:HXZ27 RS29365
gene id: 47853:HXZ27_RS29365
uniprot id: A0A1C4TYW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

47853:HXZ27 RS27560
gene id: 47853:HXZ27_RS27560
uniprot id: A0A1C4UFJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

47853:HXZ27 RS25695
gene id: 47853:HXZ27_RS25695
uniprot id: A0A1C5AKD2
names: Similarity
messages: Belongs to the asp23 family.

47853:HXZ27 RS31750
gene id: 47853:HXZ27_RS31750
uniprot id: A0A1C5AQY6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

47853:HXZ27 RS25530
gene id: 47853:HXZ27_RS25530
uniprot id: A0A1C5AL26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

47853:HXZ27 RS03075
gene id: 47853:HXZ27_RS03075
uniprot id: A0A1C4YLW2
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

47853:HXZ27 RS06600
gene id: 47853:HXZ27_RS06600
uniprot id: A0A1C5AS08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

47853:HXZ27 RS31270
gene id: 47853:HXZ27_RS31270
uniprot id: A0A1C5AQG1
names: Similarity
messages: Belongs to the arginine deiminase family.

47853:HXZ27 RS27685
gene id: 47853:HXZ27_RS27685
uniprot id: A0A1C4UE86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

47853:HXZ27 RS27285
gene id: 47853:HXZ27_RS27285
uniprot id: A0A1C4UIA4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

47853:HXZ27 RS00355
gene id: 47853:HXZ27_RS00355
uniprot id: A0A1C4Z7H6
names: Similarity
messages: Belongs to the UPF0749 family.

47853:HXZ27 RS27050
gene id: 47853:HXZ27_RS27050
uniprot id: A0A1C4UK87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

47853:HXZ27 RS22900
gene id: 47853:HXZ27_RS22900
uniprot id: A0A1C4Y702
names: Similarity
messages: Belongs to the glutathione peroxidase family.

47853:HXZ27 RS21815
gene id: 47853:HXZ27_RS21815
uniprot id: A0A1C4X7M0
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

47853:HXZ27 RS17785
gene id: 47853:HXZ27_RS17785
uniprot id: A0A1C5AHL3
names: Similarity
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Homohexamer. Assembles into a hexameric ring structure.

47853:HXZ27 RS01980
gene id: 47853:HXZ27_RS01980
uniprot id: A0A1C4YY12
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

47853:HXZ27 RS27505
gene id: 47853:HXZ27_RS27505
uniprot id: A0A1C4UG21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

47853:HXZ27 RS06620
gene id: 47853:HXZ27_RS06620
uniprot id: A0A1C5ARV9
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Purine nucleoside phosphorylase involved in purine salvage.

47853:HXZ27 RS28585
gene id: 47853:HXZ27_RS28585
uniprot id: A0A1C4U530
names: Similarity
messages: Belongs to the PstS family.

47853:HXZ27 RS06630
gene id: 47853:HXZ27_RS06630
uniprot id: A0A1C5ARV2
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

47853:HXZ27 RS04205
gene id: 47853:HXZ27_RS04205
uniprot id: A0A1C5AEI7
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

47853:HXZ27 RS23820
gene id: 47853:HXZ27_RS23820
uniprot id: A0A1C4XWI5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

47853:HXZ27 RS27585
gene id: 47853:HXZ27_RS27585
uniprot id: A0A1C4UF45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

47853:HXZ27 RS23085
gene id: 47853:HXZ27_RS23085
uniprot id: A0A1C4Y572
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Cell membrane
messages: Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.

47853:HXZ27 RS08790
gene id: 47853:HXZ27_RS08790
uniprot id: A0A1C4WHE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

47853:HXZ27 RS22560
gene id: 47853:HXZ27_RS22560
uniprot id: A0A1C4XFH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

47853:HXZ27 RS18475
gene id: 47853:HXZ27_RS18475
uniprot id: A0A1C5AJN1
names: Similarity
messages: Belongs to the ABC transporter superfamily.

47853:HXZ27 RS08125
gene id: 47853:HXZ27_RS08125
uniprot id: A0A1C4WBW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A probable RNA-binding protein.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm

47853:HXZ27 RS24265
gene id: 47853:HXZ27_RS24265
uniprot id: A0A1C4XSN7
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

47853:HXZ27 RS27635
gene id: 47853:HXZ27_RS27635
uniprot id: A0A1C4UEK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

47853:HXZ27 RS25710
gene id: 47853:HXZ27_RS25710
uniprot id: A0A7H8XR06
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

47853:HXZ27 RS22945
gene id: 47853:HXZ27_RS22945
uniprot id: A0A1C4Y6I2
names: Caution
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Exonuclease that cleaves single-stranded 3' overhangs of double-stranded RNA.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47853:HXZ27 RS14210
gene id: 47853:HXZ27_RS14210
uniprot id: A0A1C4ZSJ2
names: Similarity
messages: Belongs to the YciI family.

47853:HXZ27 RS25115
gene id: 47853:HXZ27_RS25115
uniprot id: A0A1C5ALU0
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

47853:HXZ27 RS25435
gene id: 47853:HXZ27_RS25435
uniprot id: A0A1C5AL00
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

47853:HXZ27 RS20480
gene id: 47853:HXZ27_RS20480
uniprot id: A0A1C5AT48
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

47853:HXZ27 RS03265
gene id: 47853:HXZ27_RS03265
uniprot id: A0A1C4YL25
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

47853:HXZ27 RS31330
gene id: 47853:HXZ27_RS31330
uniprot id: A0A7H8XW90
names: Similarity
names: Subunit
messages: Belongs to the Bpa family.
messages: Forms a homooligomeric, either hexameric or heptameric, ring-like structure which stacks co-axially with the proteasomal alpha-rings.

47853:HXZ27 RS25795
gene id: 47853:HXZ27_RS25795
uniprot id: A0A1C4UXS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

47853:HXZ27 RS08015
gene id: 47853:HXZ27_RS08015
uniprot id: A0A7H8XTQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

47853:HXZ27 RS07265
gene id: 47853:HXZ27_RS07265
uniprot id: A0A1C4W3Q9
names: Subcellular Location Annotation
messages: Membrane

47853:HXZ27 RS29190
gene id: 47853:HXZ27_RS29190
uniprot id: A0A1C4U025
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

47853:HXZ27 RS21570
gene id: 47853:HXZ27_RS21570
uniprot id: A0A1C4X555
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

47853:HXZ27 RS27680
gene id: 47853:HXZ27_RS27680
uniprot id: A0A1C4UE96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

47853:HXZ27 RS29750
gene id: 47853:HXZ27_RS29750
uniprot id: A0A1C4TWC7
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

47853:HXZ27 RS27485
gene id: 47853:HXZ27_RS27485
uniprot id: A0A1C4UG85
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47853:HXZ27 RS10765
gene id: 47853:HXZ27_RS10765
uniprot id: A0A1C4ZDT7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

47853:HXZ27 RS23945
gene id: 47853:HXZ27_RS23945
uniprot id: A0A1C4XVA0
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

47853:HXZ27 RS03055
gene id: 47853:HXZ27_RS03055
uniprot id: A0A1C4YM47
names: Similarity
messages: Belongs to the CsoR family.

47853:HXZ27 RS01960
gene id: 47853:HXZ27_RS01960
uniprot id: A0A1C4YXZ4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

47853:HXZ27 RS04430
gene id: 47853:HXZ27_RS04430
uniprot id: A0A1C5AFX4
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

47853:HXZ27 RS01955
gene id: 47853:HXZ27_RS01955
uniprot id: A0A1C4YZ00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

47853:HXZ27 RS23210
gene id: 47853:HXZ27_RS23210
uniprot id: A0A1C4Y3Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

47853:HXZ27 RS28620
gene id: 47853:HXZ27_RS28620
uniprot id: A0A1C4U4J6
names: Similarity
messages: Belongs to the PhoU family.
messages: Belongs to the UPF0111 family.

47853:HXZ27 RS06595
gene id: 47853:HXZ27_RS06595
uniprot id: A0A1C5ARY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

47853:HXZ27 RS21955
gene id: 47853:HXZ27_RS21955
uniprot id: A0A1C4X8Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

47853:HXZ27 RS02005
gene id: 47853:HXZ27_RS02005
uniprot id: A0A1C4YXE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

47853:HXZ27 RS00720
gene id: 47853:HXZ27_RS00720
uniprot id: A0A1C4Z4V4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

47853:HXZ27 RS30885
gene id: 47853:HXZ27_RS30885
uniprot id: A0A7H8XVC8
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus membrane

47853:HXZ27 RS27660
gene id: 47853:HXZ27_RS27660
uniprot id: A0A1C4UEG0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

47853:HXZ27 RS17795
gene id: 47853:HXZ27_RS17795
uniprot id: A0A7D6CGN6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic ubiquitin-like protein family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.
messages: Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half. There is one Pup binding site per ARC hexamer ring.
messages: The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome.

47853:HXZ27 RS17605
gene id: 47853:HXZ27_RS17605
uniprot id: A0A1C4VV28
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

47853:HXZ27 RS07995
gene id: 47853:HXZ27_RS07995
uniprot id: A0A1C4WA97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

47853:HXZ27 RS04630
gene id: 47853:HXZ27_RS04630
uniprot id: A0A1C5AFW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

47853:HXZ27 RS22630
gene id: 47853:HXZ27_RS22630
uniprot id: A0A1C4XFG7
names: Similarity
messages: Belongs to the YggT family.

47853:HXZ27 RS21950
gene id: 47853:HXZ27_RS21950
uniprot id: A0A1C4X8P2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

47853:HXZ27 RS08150
gene id: 47853:HXZ27_RS08150
uniprot id: A0A7H8XKT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

47853:HXZ27 RS27715
gene id: 47853:HXZ27_RS27715
uniprot id: A0A7H8XTI1
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

47853:HXZ27 RS02465
gene id: 47853:HXZ27_RS02465
uniprot id: A0A7H8XF37
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

47853:HXZ27 RS09980
gene id: 47853:HXZ27_RS09980
uniprot id: A0A1C5AXF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SsgA family.
messages: Cell septum

47853:HXZ27 RS04365
gene id: 47853:HXZ27_RS04365
uniprot id: A0A1C5AFJ7
names: Similarity
messages: Belongs to the thioredoxin family.

47853:HXZ27 RS08075
gene id: 47853:HXZ27_RS08075
uniprot id: A0A1C4WC41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

47853:HXZ27 RS20765
gene id: 47853:HXZ27_RS20765
uniprot id: A0A7H8XRF2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

47853:HXZ27 RS00550
gene id: 47853:HXZ27_RS00550
uniprot id: A0A1C4Z606
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

47853:HXZ27 RS07475
gene id: 47853:HXZ27_RS07475
uniprot id: A0A1C4W679
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47853:HXZ27 RS17435
gene id: 47853:HXZ27_RS17435
uniprot id: A0A1C4VTB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

47853:HXZ27 RS27495
gene id: 47853:HXZ27_RS27495
uniprot id: A0A1C4UG19
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

47853:HXZ27 RS05560
gene id: 47853:HXZ27_RS05560
uniprot id: A0A1C5A516
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics.
messages: Belongs to the MshB deacetylase family. Mca subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Monomer.

47853:HXZ27 RS27520
gene id: 47853:HXZ27_RS27520
uniprot id: A0A1C4UFZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

47853:HXZ27 RS26940
gene id: 47853:HXZ27_RS26940
uniprot id: A0A1C4ULB0
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.

47853:HXZ27 RS02795
gene id: 47853:HXZ27_RS02795
uniprot id: A0A1C4YNX0
names: Subcellular Location Annotation
messages: Membrane

47853:HXZ27 RS09100
gene id: 47853:HXZ27_RS09100
uniprot id: A0A1C4WKB4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

47853:HXZ27 RS06590
gene id: 47853:HXZ27_RS06590
uniprot id: A0A7H8XGV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

47853:HXZ27 RS19890
gene id: 47853:HXZ27_RS19890
uniprot id: A0A7H8XR27
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

47853:HXZ27 RS27720
gene id: 47853:HXZ27_RS27720
uniprot id: A0A1C4UDV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

47853:HXZ27 RS25815
gene id: 47853:HXZ27_RS25815
uniprot id: A0A7H8XQ89
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

47853:HXZ27 RS18375
gene id: 47853:HXZ27_RS18375
uniprot id: A0A1C5AJ91
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

47853:HXZ27 RS27540
gene id: 47853:HXZ27_RS27540
uniprot id: A0A1C4UFL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

47853:HXZ27 RS13250
gene id: 47853:HXZ27_RS13250
uniprot id: A0A1C5APG7
names: Subcellular Location Annotation
messages: Membrane

47853:HXZ27 RS02020
gene id: 47853:HXZ27_RS02020
uniprot id: A0A1C4YXF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

47853:HXZ27 RS28215
gene id: 47853:HXZ27_RS28215
uniprot id: A0A1C4U905
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

47853:HXZ27 RS22595
gene id: 47853:HXZ27_RS22595
uniprot id: A0A1C4XFA9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

47853:HXZ27 RS15015
gene id: 47853:HXZ27_RS15015
uniprot id: A0A1C4ZN20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

47853:HXZ27 RS04475
gene id: 47853:HXZ27_RS04475
uniprot id: A0A1C5AFI3
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

47853:HXZ27 RS17815
gene id: 47853:HXZ27_RS17815
uniprot id: A0A1C5AHK3
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
messages: Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
messages: The reaction mechanism probably proceeds via the activation of Pup by phosphorylation of its C-terminal glutamate, which is then subject to nucleophilic attack by the substrate lysine, resulting in an isopeptide bond and the release of phosphate as a good leaving group.

47853:HXZ27 RS08160
gene id: 47853:HXZ27_RS08160
uniprot id: A0A1C4WCF8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

47853:HXZ27 RS22600
gene id: 47853:HXZ27_RS22600
uniprot id: A0A1C4XFM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

47853:HXZ27 RS25865
gene id: 47853:HXZ27_RS25865
uniprot id: A0A7D6CEV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

47853:HXZ27 RS23765
gene id: 47853:HXZ27_RS23765
uniprot id: A0A1C4XX66
names: Subcellular Location Annotation
messages: Membrane

47853:HXZ27 RS21405
gene id: 47853:HXZ27_RS21405
uniprot id: A0A1C4X4E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

47853:HXZ27 RS00620
gene id: 47853:HXZ27_RS00620
uniprot id: A0A1C4Z5V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0719 family.
messages: Membrane

47853:HXZ27 RS21940
gene id: 47853:HXZ27_RS21940
uniprot id: A0A1C4X8X7
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

47853:HXZ27 RS22710
gene id: 47853:HXZ27_RS22710
uniprot id: A0A1C4XGP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobB/CobQ family. GatD subfamily.
messages: Forms a heterodimer with MurT.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.

47853:HXZ27 RS27690
gene id: 47853:HXZ27_RS27690
uniprot id: A0A1C4UE49
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

47853:HXZ27 RS15990
gene id: 47853:HXZ27_RS15990
uniprot id: A0A1C4VE62
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

47853:HXZ27 RS02630
gene id: 47853:HXZ27_RS02630
uniprot id: A0A1C4YQK1
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

47853:HXZ27 RS00035
gene id: 47853:HXZ27_RS00035
uniprot id: A0A1C5AR08
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

47853:HXZ27 RS08560
gene id: 47853:HXZ27_RS08560
uniprot id: A0A1C4WF53
names: Similarity
messages: Belongs to the F420H(2)-dependent quinone reductase family.

47853:HXZ27 RS20390
gene id: 47853:HXZ27_RS20390
uniprot id: A0A7D6C834
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

47853:HXZ27 RS27705
gene id: 47853:HXZ27_RS27705
uniprot id: A0A1C4UDZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

47853:HXZ27 RS18700
gene id: 47853:HXZ27_RS18700
uniprot id: A0A1C5AYW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

47853:HXZ27 RS11155
gene id: 47853:HXZ27_RS11155
uniprot id: A0A7H8XJ88
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

47853:HXZ27 RS31510
gene id: 47853:HXZ27_RS31510
uniprot id: A0A1C5AQL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

47853:HXZ27 RS24595
gene id: 47853:HXZ27_RS24595
uniprot id: A0A1C4XNP7
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

47853:HXZ27 RS04170
gene id: 47853:HXZ27_RS04170
uniprot id: A0A1C5AEE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

47853:HXZ27 RS08140
gene id: 47853:HXZ27_RS08140
uniprot id: A0A1C4WBW7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

47853:HXZ27 RS28350
gene id: 47853:HXZ27_RS28350
uniprot id: A0A1C4U7Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

47853:HXZ27 RS11680
gene id: 47853:HXZ27_RS11680
uniprot id: A0A1C4ZJ95
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.
messages: Cell membrane
messages: Contains a di-nuclear catalytic Mg(2+) center.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

47853:HXZ27 RS05650
gene id: 47853:HXZ27_RS05650
uniprot id: A0A7H8XGE2
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

47853:HXZ27 RS16030
gene id: 47853:HXZ27_RS16030
uniprot id: A0A1C4VF06
names: Similarity
messages: Belongs to the WrbA family.

47853:HXZ27 RS31570
gene id: 47853:HXZ27_RS31570
uniprot id: A0A1C5AQN9
names: Similarity
messages: Belongs to the AP endonuclease 2 family.

47853:HXZ27 RS26615
gene id: 47853:HXZ27_RS26615
uniprot id: A0A1C4UPF8
names: Subcellular Location Annotation
messages: Cytoplasm

47853:HXZ27 RS07730
gene id: 47853:HXZ27_RS07730
uniprot id: A0A1C4W7W1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47853:HXZ27 RS27620
gene id: 47853:HXZ27_RS27620
uniprot id: A0A7H8XS19
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

47853:HXZ27 RS04850
gene id: 47853:HXZ27_RS04850
uniprot id: A0A7H8XJA5
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

47853:HXZ27 RS08940
gene id: 47853:HXZ27_RS08940
uniprot id: A0A1C4WIU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

47853:HXZ27 RS25950
gene id: 47853:HXZ27_RS25950
uniprot id: A0A1C4UVX8
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

47853:HXZ27 RS19060
gene id: 47853:HXZ27_RS19060
uniprot id: A0A1C4ZVW9
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

47853:HXZ27 RS20775
gene id: 47853:HXZ27_RS20775
uniprot id: A0A1C5ATM2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

47853:HXZ27 RS05010
gene id: 47853:HXZ27_RS05010
uniprot id: A0A1C5A749
names: Function
names: Similarity
messages: Belongs to the IMPDH/GMPR family. GuaB1 subfamily.
messages: Involved in the purine-salvage pathway. Catalyzes the NADPH-dependent conversion of GMP to IMP.

47853:HXZ27 RS07980
gene id: 47853:HXZ27_RS07980
uniprot id: A0A1C4WA47
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.

47853:HXZ27 RS11775
gene id: 47853:HXZ27_RS11775
uniprot id: A0A1C4ZKF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

47853:HXZ27 RS05030
gene id: 47853:HXZ27_RS05030
uniprot id: A0A1C5A6X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

47853:HXZ27 RS24655
gene id: 47853:HXZ27_RS24655
uniprot id: A0A1C4XN94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

47853:HXZ27 RS20500
gene id: 47853:HXZ27_RS20500
uniprot id: A0A1C5ASX9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

47853:HXZ27 RS02070
gene id: 47853:HXZ27_RS02070
uniprot id: A0A1C4YXD7
names: Similarity
messages: Belongs to the WXG100 family.

47853:HXZ27 RS08330
gene id: 47853:HXZ27_RS08330
uniprot id: A0A1C4WCT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

47853:HXZ27 RS29040
gene id: 47853:HXZ27_RS29040
uniprot id: A0A1C4U149
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

47853:HXZ27 RS31565
gene id: 47853:HXZ27_RS31565
uniprot id: A0A1C5AQM6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

47853:HXZ27 RS02480
gene id: 47853:HXZ27_RS02480
uniprot id: A0A1C4YSI2
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

47853:HXZ27 RS08340
gene id: 47853:HXZ27_RS08340
uniprot id: A0A1C4WCY3
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

47853:HXZ27 RS24405
gene id: 47853:HXZ27_RS24405
uniprot id: A0A1C4XS22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

47853:HXZ27 RS27645
gene id: 47853:HXZ27_RS27645
uniprot id: A0A1C4UEK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

47853:HXZ27 RS20430
gene id: 47853:HXZ27_RS20430
uniprot id: A0A1C5ASP0
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

47853:HXZ27 RS20365
gene id: 47853:HXZ27_RS20365
uniprot id: A0A1C5ASK7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

47853:HXZ27 RS23120
gene id: 47853:HXZ27_RS23120
uniprot id: A0A1C4Y4T7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with subunits I, II and III to form cytochrome c oxidase.
messages: Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
messages: Cell membrane
messages: Membrane
messages: Part of cytochrome c oxidase, its function is unknown.

47853:HXZ27 RS14295
gene id: 47853:HXZ27_RS14295
uniprot id: A0A7H8XL01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

47853:HXZ27 RS00875
gene id: 47853:HXZ27_RS00875
uniprot id: A0A1C4Z3Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

47853:HXZ27 RS26955
gene id: 47853:HXZ27_RS26955
uniprot id: A0A1C4UL18
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

47853:HXZ27 RS08595
gene id: 47853:HXZ27_RS08595
uniprot id: A0A1C4WGA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

47853:HXZ27 RS07055
gene id: 47853:HXZ27_RS07055
uniprot id: A0A1C4W1R7
names: Similarity
messages: Belongs to the glycosyl hydrolase 12 (cellulase H) family.

47853:HXZ27 RS21965
gene id: 47853:HXZ27_RS21965
uniprot id: A0A1C4X8T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm

47853:HXZ27 RS21365
gene id: 47853:HXZ27_RS21365
uniprot id: A0A1C4X3E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

47853:HXZ27 RS07505
gene id: 47853:HXZ27_RS07505
uniprot id: A0A7D5Y6T2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

47853:HXZ27 RS04275
gene id: 47853:HXZ27_RS04275
uniprot id: A0A1C5AET4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

47853:HXZ27 RS13225
gene id: 47853:HXZ27_RS13225
uniprot id: A0A1C5ANT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

47853:HXZ27 RS02995
gene id: 47853:HXZ27_RS02995
uniprot id: A0A1C4YNN8
names: Similarity
messages: Belongs to the WXG100 family.

47853:HXZ27 RS25130
gene id: 47853:HXZ27_RS25130
uniprot id: A0A1C5AM06
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.

47853:HXZ27 RS10570
gene id: 47853:HXZ27_RS10570
uniprot id: A0A1C4ZCJ1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

47853:HXZ27 RS26960
gene id: 47853:HXZ27_RS26960
uniprot id: A0A1C4UL41
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

47853:HXZ27 RS19330
gene id: 47853:HXZ27_RS19330
uniprot id: A0A1C4ZXD3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

47853:HXZ27 RS02450
gene id: 47853:HXZ27_RS02450
uniprot id: A0A1C4YRK0
names: Similarity
messages: Belongs to the Nudix hydrolase family.

47853:HXZ27 RS22080
gene id: 47853:HXZ27_RS22080
uniprot id: A0A1C4XAL5
names: Subcellular Location Annotation
messages: Cytoplasm

47853:HXZ27 RS12905
gene id: 47853:HXZ27_RS12905
uniprot id: A0A1C5AN33
names: Similarity
messages: Belongs to the BMP lipoprotein family.

47853:HXZ27 RS04975
gene id: 47853:HXZ27_RS04975
uniprot id: A0A1C5A779
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

47853:HXZ27 RS00215
gene id: 47853:HXZ27_RS00215
uniprot id: A0A1C4Z8G6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

47853:HXZ27 RS07735
gene id: 47853:HXZ27_RS07735
uniprot id: A0A1C4W7U5
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

47853:HXZ27 RS22625
gene id: 47853:HXZ27_RS22625
uniprot id: A0A1C4XFC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DivIVA family.
messages: Cytoplasm

47853:HXZ27 RS22645
gene id: 47853:HXZ27_RS22645
uniprot id: A0A7H8XP79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

47853:HXZ27 RS28355
gene id: 47853:HXZ27_RS28355
uniprot id: A0A1C4U7N5
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

47853:HXZ27 RS26995
gene id: 47853:HXZ27_RS26995
uniprot id: A0A1C4UKW2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

47853:HXZ27 RS00870
gene id: 47853:HXZ27_RS00870
uniprot id: A0A1C4Z3V7
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

47853:HXZ27 RS08995
gene id: 47853:HXZ27_RS08995
uniprot id: A0A1C4WK55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

47853:HXZ27 RS17370
gene id: 47853:HXZ27_RS17370
uniprot id: A0A1C4VSP9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

47853:HXZ27 RS27630
gene id: 47853:HXZ27_RS27630
uniprot id: A0A1C4UET2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

47853:HXZ27 RS00695
gene id: 47853:HXZ27_RS00695
uniprot id: A0A1C4Z565
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

47853:HXZ27 RS04875
gene id: 47853:HXZ27_RS04875
uniprot id: A0A1C5A7P5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

47853:HXZ27 RS07430
gene id: 47853:HXZ27_RS07430
uniprot id: A0A1C4W5Z2
names: Subcellular Location Annotation
messages: Membrane

47853:HXZ27 RS07275
gene id: 47853:HXZ27_RS07275
uniprot id: A0A1C4W416
names: Subcellular Location Annotation
messages: Membrane

47853:HXZ27 RS04470
gene id: 47853:HXZ27_RS04470
uniprot id: A0A1C5AFF6
names: Similarity
messages: Belongs to the UDPGP type 2 family.

47853:HXZ27 RS16440
gene id: 47853:HXZ27_RS16440
uniprot id: A0A1C4VIQ8
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

47853:HXZ27 RS20760
gene id: 47853:HXZ27_RS20760
uniprot id: A0A7H8XNQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

47853:HXZ27 RS01680
gene id: 47853:HXZ27_RS01680
uniprot id: A0A7H8XDP0
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

47853:HXZ27 RS23095
gene id: 47853:HXZ27_RS23095
uniprot id: A0A7H8XSI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

47853:HXZ27 RS08980
gene id: 47853:HXZ27_RS08980
uniprot id: A0A1C4WJ85
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

47853:HXZ27 RS07385
gene id: 47853:HXZ27_RS07385
uniprot id: A0A1C4W524
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

47853:HXZ27 RS27535
gene id: 47853:HXZ27_RS27535
uniprot id: A0A1C4UFP3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

47853:HXZ27 RS27740
gene id: 47853:HXZ27_RS27740
uniprot id: A0A1C4UDN0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

47853:HXZ27 RS07140
gene id: 47853:HXZ27_RS07140
uniprot id: A0A1C4W2R0
names: Subcellular Location Annotation
messages: Membrane

47853:HXZ27 RS12755
gene id: 47853:HXZ27_RS12755
uniprot id: A0A1C5AV03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

47853:HXZ27 RS21960
gene id: 47853:HXZ27_RS21960
uniprot id: A0A1C4X8Q6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

47853:HXZ27 RS23110
gene id: 47853:HXZ27_RS23110
uniprot id: A0A1C4Y523
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47853:HXZ27 RS25855
gene id: 47853:HXZ27_RS25855
uniprot id: A0A7H8XTV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

47853:HXZ27 RS26145
gene id: 47853:HXZ27_RS26145
uniprot id: A0A1C4UU32
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

47853:HXZ27 RS21970
gene id: 47853:HXZ27_RS21970
uniprot id: A0A1C4X8X1
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

47853:HXZ27 RS29740
gene id: 47853:HXZ27_RS29740
uniprot id: A0A7H8XS98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

47853:HXZ27 RS27615
gene id: 47853:HXZ27_RS27615
uniprot id: A0A1C4UEU7
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

47853:HXZ27 RS14755
gene id: 47853:HXZ27_RS14755
uniprot id: A0A1C4ZPC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

47853:HXZ27 RS25805
gene id: 47853:HXZ27_RS25805
uniprot id: A0A7H8XTU5
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

47853:HXZ27 RS22860
gene id: 47853:HXZ27_RS22860
uniprot id: A0A1C4Y7B3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

47853:HXZ27 RS31680
gene id: 47853:HXZ27_RS31680
uniprot id: A0A1C5AQX5
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

47853:HXZ27 RS27710
gene id: 47853:HXZ27_RS27710
uniprot id: A0A1C4UDW8
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

47853:HXZ27 RS25840
gene id: 47853:HXZ27_RS25840
uniprot id: A0A1C4UX15
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

47853:HXZ27 RS27530
gene id: 47853:HXZ27_RS27530
uniprot id: A0A1C4UFR1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

47853:HXZ27 RS26390
gene id: 47853:HXZ27_RS26390
uniprot id: A0A1C4URL7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

47853:HXZ27 RS23205
gene id: 47853:HXZ27_RS23205
uniprot id: A0A1C4Y514
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

47853:HXZ27 RS05140
gene id: 47853:HXZ27_RS05140
uniprot id: A0A1C5A706
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47853:HXZ27 RS23090
gene id: 47853:HXZ27_RS23090
uniprot id: A0A1C4Y527
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds 2 heme c groups covalently per subunit.
messages: Cell membrane
messages: Membrane
messages: The cytochrome bc1 complex is composed of a cytochrome b (QcrB), the Rieske iron-sulfur protein (QcrA) and a diheme cytochrome c (QcrC) subunit.

47853:HXZ27 RS22055
gene id: 47853:HXZ27_RS22055
uniprot id: A0A1C4X9N1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

47853:HXZ27 RS08130
gene id: 47853:HXZ27_RS08130
uniprot id: A0A1C4WC50
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

47853:HXZ27 RS17175
gene id: 47853:HXZ27_RS17175
uniprot id: A0A1C4VR58
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

47853:HXZ27 RS12550
gene id: 47853:HXZ27_RS12550
uniprot id: A0A1C5AV76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

47853:HXZ27 RS29605
gene id: 47853:HXZ27_RS29605
uniprot id: A0A1C4TXE1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

47853:HXZ27 RS04685
gene id: 47853:HXZ27_RS04685
uniprot id: A0A1C5AG77
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

47853:HXZ27 RS31645
gene id: 47853:HXZ27_RS31645
uniprot id: A0A1C5AQQ8
names: Similarity
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.

47853:HXZ27 RS13795
gene id: 47853:HXZ27_RS13795
uniprot id: A0A1C5AWQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

47853:HXZ27 RS22245
gene id: 47853:HXZ27_RS22245
uniprot id: A0A7H8XQ26
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

47853:HXZ27 RS04900
gene id: 47853:HXZ27_RS04900
uniprot id: A0A1C5A7K7
names: Similarity
messages: Belongs to the UPRTase family.

47853:HXZ27 RS04800
gene id: 47853:HXZ27_RS04800
uniprot id: A0A7H8XIJ2
names: Subcellular Location Annotation
messages: Membrane

47853:HXZ27 RS15060
gene id: 47853:HXZ27_RS15060
uniprot id: A0A1C4ZMF0
names: Similarity
messages: Belongs to the ABC transporter superfamily.

47853:HXZ27 RS00955
gene id: 47853:HXZ27_RS00955
uniprot id: A0A1C4Z3F6
names: Similarity
messages: Belongs to the AHA1 family.

47853:HXZ27 RS19815
gene id: 47853:HXZ27_RS19815
uniprot id: A0A1C5A004
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase-binding protein RbpA family.
messages: Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
messages: Forms a complex with the RNAP catalytic core and with free principal sigma factors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

47853:HXZ27 RS31740
gene id: 47853:HXZ27_RS31740
uniprot id: A0A7H8XT59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

47853:HXZ27 RS29150
gene id: 47853:HXZ27_RS29150
uniprot id: A0A1C4U074
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

47853:HXZ27 RS28405
gene id: 47853:HXZ27_RS28405
uniprot id: A0A1C4U7A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

47853:HXZ27 RS00840
gene id: 47853:HXZ27_RS00840
uniprot id: A0A1C4Z3Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

47853:HXZ27 RS19515
gene id: 47853:HXZ27_RS19515
uniprot id: A0A1C4ZXX9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

47853:HXZ27 RS20525
gene id: 47853:HXZ27_RS20525
uniprot id: A0A1C5ASS2
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

47853:HXZ27 RS05720
gene id: 47853:HXZ27_RS05720
uniprot id: A0A1C5A4H6
names: Similarity
messages: Belongs to the asparaginase 1 family.

47853:HXZ27 RS06420
gene id: 47853:HXZ27_RS06420
uniprot id: A0A1C5ARK2
names: Subcellular Location Annotation
messages: Secreted