456442:MBOO RS11145
gene id: 456442:MBOO_RS11145
uniprot id: A7IA91
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

456442:MBOO RS09500
gene id: 456442:MBOO_RS09500
uniprot id: A7I9C9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

456442:MBOO RS09840
gene id: 456442:MBOO_RS09840
uniprot id: A7I9J3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

456442:MBOO RS00140
gene id: 456442:MBOO_RS00140
uniprot id: A7I491
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

456442:MBOO RS01590
gene id: 456442:MBOO_RS01590
uniprot id: A7I526
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

456442:MBOO RS12690
gene id: 456442:MBOO_RS12690
uniprot id: A7IB31
names: Similarity
messages: Belongs to the LarC family.

456442:MBOO RS09945
gene id: 456442:MBOO_RS09945
uniprot id: A7I9L5
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

456442:MBOO RS04705
gene id: 456442:MBOO_RS04705
uniprot id: A7I6Q3
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS09740
gene id: 456442:MBOO_RS09740
uniprot id: A7I9H2
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

456442:MBOO RS06280
gene id: 456442:MBOO_RS06280
uniprot id: A7I7L0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.

456442:MBOO RS08720
gene id: 456442:MBOO_RS08720
uniprot id: A7I8X8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

456442:MBOO RS12270
gene id: 456442:MBOO_RS12270
uniprot id: A7IAU9
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

456442:MBOO RS06800
gene id: 456442:MBOO_RS06800
uniprot id: A7I7V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

456442:MBOO RS09335
gene id: 456442:MBOO_RS09335
uniprot id: A7I998
names: Similarity
messages: Belongs to the archease family.

456442:MBOO RS12490
gene id: 456442:MBOO_RS12490
uniprot id: A7IAZ5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

456442:MBOO RS09135
gene id: 456442:MBOO_RS09135
uniprot id: A7I961
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.

456442:MBOO RS05600
gene id: 456442:MBOO_RS05600
uniprot id: A7I779
names: Similarity
messages: Belongs to the MtxX family.

456442:MBOO RS09570
gene id: 456442:MBOO_RS09570
uniprot id: A7I9E1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

456442:MBOO RS02890
gene id: 456442:MBOO_RS02890
uniprot id: A7I5R3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

456442:MBOO RS10135
gene id: 456442:MBOO_RS10135
uniprot id: A7I9P9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

456442:MBOO RS03965
gene id: 456442:MBOO_RS03965
uniprot id: A7I6B8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

456442:MBOO RS02425
gene id: 456442:MBOO_RS02425
uniprot id: A7I5H7
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

456442:MBOO RS06445
gene id: 456442:MBOO_RS06445
uniprot id: A7I7P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

456442:MBOO RS02420
gene id: 456442:MBOO_RS02420
uniprot id: A7I5H6
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

456442:MBOO RS03215
gene id: 456442:MBOO_RS03215
uniprot id: A7I5X9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.

456442:MBOO RS11615
gene id: 456442:MBOO_RS11615
uniprot id: A7IAH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

456442:MBOO RS00055
gene id: 456442:MBOO_RS00055
uniprot id: A7I474
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS08650
gene id: 456442:MBOO_RS08650
uniprot id: A7I8W4
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

456442:MBOO RS08895
gene id: 456442:MBOO_RS08895
uniprot id: A7I913
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

456442:MBOO RS12820
gene id: 456442:MBOO_RS12820
uniprot id: A7IB56
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS05880
gene id: 456442:MBOO_RS05880
uniprot id: A7I7D2
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS02880
gene id: 456442:MBOO_RS02880
uniprot id: A7I5R1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

456442:MBOO RS11690
gene id: 456442:MBOO_RS11690
uniprot id: A7IAJ1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

456442:MBOO RS00805
gene id: 456442:MBOO_RS00805
uniprot id: A7I4L9
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

456442:MBOO RS11990
gene id: 456442:MBOO_RS11990
uniprot id: A7IAP7
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

456442:MBOO RS00015
gene id: 456442:MBOO_RS00015
uniprot id: A7I466
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

456442:MBOO RS12220
gene id: 456442:MBOO_RS12220
uniprot id: A7IAU0
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

456442:MBOO RS04870
gene id: 456442:MBOO_RS04870
uniprot id: A7I6T7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

456442:MBOO RS08185
gene id: 456442:MBOO_RS08185
uniprot id: A7I8M0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

456442:MBOO RS08090
gene id: 456442:MBOO_RS08090
uniprot id: A7I8K1
names: Similarity
messages: Belongs to the UPF0677 family.

456442:MBOO RS03075
gene id: 456442:MBOO_RS03075
uniprot id: A7I5V0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

456442:MBOO RS05085
gene id: 456442:MBOO_RS05085
uniprot id: A7I6Y0
names: Similarity
messages: Belongs to the DtxR/MntR family.

456442:MBOO RS04190
gene id: 456442:MBOO_RS04190
uniprot id: A7I6G1
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

456442:MBOO RS06675
gene id: 456442:MBOO_RS06675
uniprot id: A7I7T4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

456442:MBOO RS10645
gene id: 456442:MBOO_RS10645
uniprot id: A7I9Z6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

456442:MBOO RS09030
gene id: 456442:MBOO_RS09030
uniprot id: A7I940
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

456442:MBOO RS00300
gene id: 456442:MBOO_RS00300
uniprot id: A7I4C3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

456442:MBOO RS02435
gene id: 456442:MBOO_RS02435
uniprot id: A7I5H9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

456442:MBOO RS02340
gene id: 456442:MBOO_RS02340
uniprot id: A7I5G1
names: Similarity
messages: Belongs to the hemerythrin family.

456442:MBOO RS06945
gene id: 456442:MBOO_RS06945
uniprot id: A7I7Y6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

456442:MBOO RS02140
gene id: 456442:MBOO_RS02140
uniprot id: A7I5C3
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS10245
gene id: 456442:MBOO_RS10245
uniprot id: A7I9S1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

456442:MBOO RS10145
gene id: 456442:MBOO_RS10145
uniprot id: A7I9Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

456442:MBOO RS09585
gene id: 456442:MBOO_RS09585
uniprot id: A7I9E4
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

456442:MBOO RS08065
gene id: 456442:MBOO_RS08065
uniprot id: A7I8J6
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

456442:MBOO RS05610
gene id: 456442:MBOO_RS05610
uniprot id: A7I781
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

456442:MBOO RS09275
gene id: 456442:MBOO_RS09275
uniprot id: A7I987
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS10350
gene id: 456442:MBOO_RS10350
uniprot id: A7I9U0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS02495
gene id: 456442:MBOO_RS02495
uniprot id: A7I5J1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

456442:MBOO RS09545
gene id: 456442:MBOO_RS09545
uniprot id: A7I9D7
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

456442:MBOO RS05535
gene id: 456442:MBOO_RS05535
uniprot id: A7I766
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS06390
gene id: 456442:MBOO_RS06390
uniprot id: A7I7N1
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

456442:MBOO RS11075
gene id: 456442:MBOO_RS11075
uniprot id: A7IA78
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: In Archaea the pyridoxal phosphate cofactor is not covalently bound to Lys but ligated by other amino acids.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

456442:MBOO RS06775
gene id: 456442:MBOO_RS06775
uniprot id: A7I7V3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

456442:MBOO RS11030
gene id: 456442:MBOO_RS11030
uniprot id: A7IA69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the threonine synthase family. Cysteate synthase subfamily.
messages: Homotrimer.
messages: Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate.

456442:MBOO RS02545
gene id: 456442:MBOO_RS02545
uniprot id: A7I5J9
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

456442:MBOO RS01795
gene id: 456442:MBOO_RS01795
uniprot id: A7I561
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS11150
gene id: 456442:MBOO_RS11150
uniprot id: A7IA92
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

456442:MBOO RS09715
gene id: 456442:MBOO_RS09715
uniprot id: A7I9G7
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS10640
gene id: 456442:MBOO_RS10640
uniprot id: A7I9Z5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS07300
gene id: 456442:MBOO_RS07300
uniprot id: A7I854
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

456442:MBOO RS00310
gene id: 456442:MBOO_RS00310
uniprot id: A7I4C5
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS06815
gene id: 456442:MBOO_RS06815
uniprot id: A7I7V9
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS11900
gene id: 456442:MBOO_RS11900
uniprot id: A7IAN1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

456442:MBOO RS12440
gene id: 456442:MBOO_RS12440
uniprot id: A7IAY4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

456442:MBOO RS04055
gene id: 456442:MBOO_RS04055
uniprot id: A7I6D5
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

456442:MBOO RS07150
gene id: 456442:MBOO_RS07150
uniprot id: A7I826
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).

456442:MBOO RS08520
gene id: 456442:MBOO_RS08520
uniprot id: A7I8T9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

456442:MBOO RS02835
gene id: 456442:MBOO_RS02835
uniprot id: A7I5Q2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

456442:MBOO RS08385
gene id: 456442:MBOO_RS08385
uniprot id: A7I8R1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

456442:MBOO RS09495
gene id: 456442:MBOO_RS09495
uniprot id: A7I9C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

456442:MBOO RS01785
gene id: 456442:MBOO_RS01785
uniprot id: A7I559
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

456442:MBOO RS10655
gene id: 456442:MBOO_RS10655
uniprot id: A7I9Z8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

456442:MBOO RS05990
gene id: 456442:MBOO_RS05990
uniprot id: A7I7F5
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

456442:MBOO RS09750
gene id: 456442:MBOO_RS09750
uniprot id: A7I9H5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

456442:MBOO RS02815
gene id: 456442:MBOO_RS02815
uniprot id: A7I5P8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

456442:MBOO RS12250
gene id: 456442:MBOO_RS12250
uniprot id: A7IAU5
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

456442:MBOO RS06055
gene id: 456442:MBOO_RS06055
uniprot id: A7I7G8
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

456442:MBOO RS04290
gene id: 456442:MBOO_RS04290
uniprot id: A7I6H7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

456442:MBOO RS09725
gene id: 456442:MBOO_RS09725
uniprot id: A7I9G9
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS03370
gene id: 456442:MBOO_RS03370
uniprot id: A7I608
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS09970
gene id: 456442:MBOO_RS09970
uniprot id: A7I9M0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

456442:MBOO RS05355
gene id: 456442:MBOO_RS05355
uniprot id: A7I732
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

456442:MBOO RS12055
gene id: 456442:MBOO_RS12055
uniprot id: A7IAR0
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

456442:MBOO RS00265
gene id: 456442:MBOO_RS00265
uniprot id: A7I4B6
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

456442:MBOO RS02720
gene id: 456442:MBOO_RS02720
uniprot id: A7I5N0
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

456442:MBOO RS08135
gene id: 456442:MBOO_RS08135
uniprot id: A7I8K8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

456442:MBOO RS02800
gene id: 456442:MBOO_RS02800
uniprot id: A7I5P5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

456442:MBOO RS07275
gene id: 456442:MBOO_RS07275
uniprot id: A7I850
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

456442:MBOO RS11830
gene id: 456442:MBOO_RS11830
uniprot id: A7IAL8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS05595
gene id: 456442:MBOO_RS05595
uniprot id: A7I778
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

456442:MBOO RS05825
gene id: 456442:MBOO_RS05825
uniprot id: A7I7C1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

456442:MBOO RS12505
gene id: 456442:MBOO_RS12505
uniprot id: A7IAZ8
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

456442:MBOO RS03650
gene id: 456442:MBOO_RS03650
uniprot id: A7I661
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

456442:MBOO RS05890
gene id: 456442:MBOO_RS05890
uniprot id: A7I7D4
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS11605
gene id: 456442:MBOO_RS11605
uniprot id: A7IAH5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

456442:MBOO RS08940
gene id: 456442:MBOO_RS08940
uniprot id: A7I922
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

456442:MBOO RS00480
gene id: 456442:MBOO_RS00480
uniprot id: A7I4F8
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

456442:MBOO RS05750
gene id: 456442:MBOO_RS05750
uniprot id: A7I7A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

456442:MBOO RS10320
gene id: 456442:MBOO_RS10320
uniprot id: A7I9T5
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

456442:MBOO RS09480
gene id: 456442:MBOO_RS09480
uniprot id: A7I9C5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

456442:MBOO RS10825
gene id: 456442:MBOO_RS10825
uniprot id: A7IA28
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

456442:MBOO RS06960
gene id: 456442:MBOO_RS06960
uniprot id: A7I7Y9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

456442:MBOO RS11995
gene id: 456442:MBOO_RS11995
uniprot id: A7IAP8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

456442:MBOO RS12630
gene id: 456442:MBOO_RS12630
uniprot id: A7IB20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

456442:MBOO RS01505
gene id: 456442:MBOO_RS01505
uniprot id: A7I508
names: Similarity
messages: Belongs to the P(II) protein family.

456442:MBOO RS11610
gene id: 456442:MBOO_RS11610
uniprot id: A7IAH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

456442:MBOO RS05005
gene id: 456442:MBOO_RS05005
uniprot id: A7I6W4
names: Similarity
messages: Belongs to the Ahb/Nir family.

456442:MBOO RS12080
gene id: 456442:MBOO_RS12080
uniprot id: A7IAR4
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

456442:MBOO RS10450
gene id: 456442:MBOO_RS10450
uniprot id: A7I9V9
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS03700
gene id: 456442:MBOO_RS03700
uniprot id: A7I671
names: Similarity
messages: Belongs to the phosphohexose mutase family.

456442:MBOO RS02275
gene id: 456442:MBOO_RS02275
uniprot id: A7I5E8
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS12770
gene id: 456442:MBOO_RS12770
uniprot id: A7IB46
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

456442:MBOO RS12695
gene id: 456442:MBOO_RS12695
uniprot id: A7IB32
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

456442:MBOO RS07140
gene id: 456442:MBOO_RS07140
uniprot id: A7I824
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS12560
gene id: 456442:MBOO_RS12560
uniprot id: A7IB07
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS11300
gene id: 456442:MBOO_RS11300
uniprot id: A7IAC1
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

456442:MBOO RS07865
gene id: 456442:MBOO_RS07865
uniprot id: A7I8G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

456442:MBOO RS08390
gene id: 456442:MBOO_RS08390
uniprot id: A7I8R2
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

456442:MBOO RS08525
gene id: 456442:MBOO_RS08525
uniprot id: A7I8U0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

456442:MBOO RS03545
gene id: 456442:MBOO_RS03545
uniprot id: A7I640
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

456442:MBOO RS11730
gene id: 456442:MBOO_RS11730
uniprot id: A7IAJ9
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

456442:MBOO RS03840
gene id: 456442:MBOO_RS03840
uniprot id: A7I698
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

456442:MBOO RS13145
gene id: 456442:MBOO_RS13145
uniprot id: A7I902
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

456442:MBOO RS03025
gene id: 456442:MBOO_RS03025
uniprot id: A7I5U0
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

456442:MBOO RS04070
gene id: 456442:MBOO_RS04070
uniprot id: A7I6D8
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS00840
gene id: 456442:MBOO_RS00840
uniprot id: A7I4M6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

456442:MBOO RS03040
gene id: 456442:MBOO_RS03040
uniprot id: A7I5U3
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

456442:MBOO RS04640
gene id: 456442:MBOO_RS04640
uniprot id: A7I6N9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

456442:MBOO RS03570
gene id: 456442:MBOO_RS03570
uniprot id: A7I645
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

456442:MBOO RS06360
gene id: 456442:MBOO_RS06360
uniprot id: A7I7M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

456442:MBOO RS08965
gene id: 456442:MBOO_RS08965
uniprot id: A7I927
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

456442:MBOO RS04685
gene id: 456442:MBOO_RS04685
uniprot id: A7I6P9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

456442:MBOO RS05725
gene id: 456442:MBOO_RS05725
uniprot id: A7I7A2
names: Subcellular Location Annotation
messages: Encapsulin nanocompartment

456442:MBOO RS09805
gene id: 456442:MBOO_RS09805
uniprot id: A7I9I6
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

456442:MBOO RS01335
gene id: 456442:MBOO_RS01335
uniprot id: A7I4X6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

456442:MBOO RS03645
gene id: 456442:MBOO_RS03645
uniprot id: A7I660
names: Similarity
messages: Belongs to the UPF0284 family.

456442:MBOO RS03110
gene id: 456442:MBOO_RS03110
uniprot id: A7I5V7
names: Similarity
messages: Belongs to the LeuD family. LeuD type 2 subfamily.

456442:MBOO RS10930
gene id: 456442:MBOO_RS10930
uniprot id: A7IA49
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

456442:MBOO RS02210
gene id: 456442:MBOO_RS02210
uniprot id: A7I5D5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

456442:MBOO RS08625
gene id: 456442:MBOO_RS08625
uniprot id: A7I8V9
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS07375
gene id: 456442:MBOO_RS07375
uniprot id: A7I868
names: Similarity
messages: Belongs to the HupF/HypC family.

456442:MBOO RS09310
gene id: 456442:MBOO_RS09310
uniprot id: A7I993
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

456442:MBOO RS11540
gene id: 456442:MBOO_RS11540
uniprot id: A7IAG3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

456442:MBOO RS01365
gene id: 456442:MBOO_RS01365
uniprot id: A7I4Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

456442:MBOO RS03560
gene id: 456442:MBOO_RS03560
uniprot id: A7I643
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

456442:MBOO RS02945
gene id: 456442:MBOO_RS02945
uniprot id: A7I5S4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Belongs to the MtrG family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

456442:MBOO RS01640
gene id: 456442:MBOO_RS01640
uniprot id: A7I535
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

456442:MBOO RS12130
gene id: 456442:MBOO_RS12130
uniprot id: A7IAS2
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

456442:MBOO RS05335
gene id: 456442:MBOO_RS05335
uniprot id: A7I728
names: Similarity
messages: Belongs to the UPF0145 family.

456442:MBOO RS02910
gene id: 456442:MBOO_RS02910
uniprot id: A7I5R7
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS08360
gene id: 456442:MBOO_RS08360
uniprot id: A7I8Q4
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS02715
gene id: 456442:MBOO_RS02715
uniprot id: A7I5M9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

456442:MBOO RS07680
gene id: 456442:MBOO_RS07680
uniprot id: A7I8C8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

456442:MBOO RS01275
gene id: 456442:MBOO_RS01275
uniprot id: A7I4W4
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

456442:MBOO RS00750
gene id: 456442:MBOO_RS00750
uniprot id: A7I4K8
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS09785
gene id: 456442:MBOO_RS09785
uniprot id: A7I9I2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

456442:MBOO RS10060
gene id: 456442:MBOO_RS10060
uniprot id: A7I9N7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

456442:MBOO RS00475
gene id: 456442:MBOO_RS00475
uniprot id: A7I4F7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.

456442:MBOO RS12280
gene id: 456442:MBOO_RS12280
uniprot id: A7IAV1
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

456442:MBOO RS04255
gene id: 456442:MBOO_RS04255
uniprot id: A7I6H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

456442:MBOO RS09830
gene id: 456442:MBOO_RS09830
uniprot id: A7I9J1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

456442:MBOO RS02475
gene id: 456442:MBOO_RS02475
uniprot id: A7I5I7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

456442:MBOO RS00585
gene id: 456442:MBOO_RS00585
uniprot id: A7I4H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

456442:MBOO RS12730
gene id: 456442:MBOO_RS12730
uniprot id: A7IB38
names: Similarity
messages: Belongs to the UPF0288 family.

456442:MBOO RS03020
gene id: 456442:MBOO_RS03020
uniprot id: A7I5T9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

456442:MBOO RS05615
gene id: 456442:MBOO_RS05615
uniprot id: A7I782
names: Similarity
messages: Belongs to the UPF0146 family.

456442:MBOO RS11135
gene id: 456442:MBOO_RS11135
uniprot id: A7IA89
names: Caution
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS04545
gene id: 456442:MBOO_RS04545
uniprot id: A7I6M3
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

456442:MBOO RS09765
gene id: 456442:MBOO_RS09765
uniprot id: A7I9H8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

456442:MBOO RS04005
gene id: 456442:MBOO_RS04005
uniprot id: A7I6C5
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

456442:MBOO RS04185
gene id: 456442:MBOO_RS04185
uniprot id: A7I6G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

456442:MBOO RS10935
gene id: 456442:MBOO_RS10935
uniprot id: A7IA50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

456442:MBOO RS11675
gene id: 456442:MBOO_RS11675
uniprot id: A7IAI8
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

456442:MBOO RS12825
gene id: 456442:MBOO_RS12825
uniprot id: A7IB57
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

456442:MBOO RS12845
gene id: 456442:MBOO_RS12845
uniprot id: A7IB61
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

456442:MBOO RS01370
gene id: 456442:MBOO_RS01370
uniprot id: A7I4Y3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

456442:MBOO RS12715
gene id: 456442:MBOO_RS12715
uniprot id: A7IB35
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

456442:MBOO RS10885
gene id: 456442:MBOO_RS10885
uniprot id: A7IA40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

456442:MBOO RS10175
gene id: 456442:MBOO_RS10175
uniprot id: A7I9Q7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

456442:MBOO RS02900
gene id: 456442:MBOO_RS02900
uniprot id: A7I5R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

456442:MBOO RS08400
gene id: 456442:MBOO_RS08400
uniprot id: A7I8R4
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

456442:MBOO RS03500
gene id: 456442:MBOO_RS03500
uniprot id: A7I631
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

456442:MBOO RS00540
gene id: 456442:MBOO_RS00540
uniprot id: A7I4G8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS09760
gene id: 456442:MBOO_RS09760
uniprot id: A7I9H7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

456442:MBOO RS04775
gene id: 456442:MBOO_RS04775
uniprot id: A7I6R8
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

456442:MBOO RS12255
gene id: 456442:MBOO_RS12255
uniprot id: A7IAU6
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

456442:MBOO RS04800
gene id: 456442:MBOO_RS04800
uniprot id: A7I6S3
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS00620
gene id: 456442:MBOO_RS00620
uniprot id: A7I4I4
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS07490
gene id: 456442:MBOO_RS07490
uniprot id: A7I890
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

456442:MBOO RS04605
gene id: 456442:MBOO_RS04605
uniprot id: A7I6N2
names: Similarity
messages: Belongs to the FwdC/FmdC family.

456442:MBOO RS10165
gene id: 456442:MBOO_RS10165
uniprot id: A7I9Q5
names: Similarity
messages: Belongs to the eIF-2-alpha family.

456442:MBOO RS02820
gene id: 456442:MBOO_RS02820
uniprot id: A7I5P9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

456442:MBOO RS08865
gene id: 456442:MBOO_RS08865
uniprot id: A7I907
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS08380
gene id: 456442:MBOO_RS08380
uniprot id: A7I8R0
names: Similarity
messages: Belongs to the ClpA/ClpB family.

456442:MBOO RS12805
gene id: 456442:MBOO_RS12805
uniprot id: A7IB53
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS03270
gene id: 456442:MBOO_RS03270
uniprot id: A7I5Z0
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS08725
gene id: 456442:MBOO_RS08725
uniprot id: A7I8X9
names: Similarity
messages: Belongs to the MCM family.

456442:MBOO RS08815
gene id: 456442:MBOO_RS08815
uniprot id: A7I8Z7
names: Similarity
messages: Belongs to the glutamate synthase family.

456442:MBOO RS10475
gene id: 456442:MBOO_RS10475
uniprot id: A7I9W4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

456442:MBOO RS01375
gene id: 456442:MBOO_RS01375
uniprot id: A7I4Y4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

456442:MBOO RS07335
gene id: 456442:MBOO_RS07335
uniprot id: A7I861
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

456442:MBOO RS08890
gene id: 456442:MBOO_RS08890
uniprot id: A7I912
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

456442:MBOO RS02750
gene id: 456442:MBOO_RS02750
uniprot id: A7I5N5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

456442:MBOO RS05450
gene id: 456442:MBOO_RS05450
uniprot id: A7I750
names: Similarity
messages: Belongs to the MtrH family.

456442:MBOO RS02830
gene id: 456442:MBOO_RS02830
uniprot id: A7I5Q1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

456442:MBOO RS11825
gene id: 456442:MBOO_RS11825
uniprot id: A7IAL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

456442:MBOO RS09305
gene id: 456442:MBOO_RS09305
uniprot id: A7I992
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

456442:MBOO RS12305
gene id: 456442:MBOO_RS12305
uniprot id: A7IAV7
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS11235
gene id: 456442:MBOO_RS11235
uniprot id: A7IAA9
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

456442:MBOO RS03890
gene id: 456442:MBOO_RS03890
uniprot id: A7I6A5
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS10185
gene id: 456442:MBOO_RS10185
uniprot id: A7I9Q9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).

456442:MBOO RS00155
gene id: 456442:MBOO_RS00155
uniprot id: A7I494
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS01525
gene id: 456442:MBOO_RS01525
uniprot id: A7I513
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

456442:MBOO RS06520
gene id: 456442:MBOO_RS06520
uniprot id: A7I7Q5
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

456442:MBOO RS02870
gene id: 456442:MBOO_RS02870
uniprot id: A7I5Q9
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

456442:MBOO RS08410
gene id: 456442:MBOO_RS08410
uniprot id: A7I8R6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

456442:MBOO RS10875
gene id: 456442:MBOO_RS10875
uniprot id: A7IA38
names: Cofactor
names: Similarity
messages: Belongs to the desulfoferrodoxin family.
messages: Binds 1 Fe(2+) ion per subunit. The iron ion 2 is coordinated via four histidines and one cysteine residue.
messages: Binds 1 Fe(3+) ion per subunit. The iron ion 1 is coordinated via 4 cysteine residues.

456442:MBOO RS10055
gene id: 456442:MBOO_RS10055
uniprot id: A7I9N6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

456442:MBOO RS11280
gene id: 456442:MBOO_RS11280
uniprot id: A7IAB7
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

456442:MBOO RS08340
gene id: 456442:MBOO_RS08340
uniprot id: A7I8Q1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

456442:MBOO RS03625
gene id: 456442:MBOO_RS03625
uniprot id: A7I656
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

456442:MBOO RS00600
gene id: 456442:MBOO_RS00600
uniprot id: A7I4I0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.

456442:MBOO RS06645
gene id: 456442:MBOO_RS06645
uniprot id: A7I7S8
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

456442:MBOO RS12425
gene id: 456442:MBOO_RS12425
uniprot id: A7IAY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

456442:MBOO RS05345
gene id: 456442:MBOO_RS05345
uniprot id: A7I730
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS00820
gene id: 456442:MBOO_RS00820
uniprot id: A7I4M2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

456442:MBOO RS10605
gene id: 456442:MBOO_RS10605
uniprot id: A7I9Y8
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

456442:MBOO RS09015
gene id: 456442:MBOO_RS09015
uniprot id: A7I937
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

456442:MBOO RS03575
gene id: 456442:MBOO_RS03575
uniprot id: A7I646
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

456442:MBOO RS10525
gene id: 456442:MBOO_RS10525
uniprot id: A7I9X3
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

456442:MBOO RS05985
gene id: 456442:MBOO_RS05985
uniprot id: A7I7F4
names: Function
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).

456442:MBOO RS09515
gene id: 456442:MBOO_RS09515
uniprot id: A7I9D2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS08330
gene id: 456442:MBOO_RS08330
uniprot id: A7I8P9
names: Similarity
messages: Belongs to the UPF0200 family.

456442:MBOO RS02760
gene id: 456442:MBOO_RS02760
uniprot id: A7I5N7
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

456442:MBOO RS04360
gene id: 456442:MBOO_RS04360
uniprot id: A7I6I8
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

456442:MBOO RS12710
gene id: 456442:MBOO_RS12710
uniprot id: A7IB34
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS03975
gene id: 456442:MBOO_RS03975
uniprot id: A7I6C0
names: Similarity
messages: Belongs to the UPF0111 family.

456442:MBOO RS08160
gene id: 456442:MBOO_RS08160
uniprot id: A7I8L5
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

456442:MBOO RS05845
gene id: 456442:MBOO_RS05845
uniprot id: A7I7C5
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

456442:MBOO RS11760
gene id: 456442:MBOO_RS11760
uniprot id: A7IAK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

456442:MBOO RS01225
gene id: 456442:MBOO_RS01225
uniprot id: A7I4V4
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

456442:MBOO RS06100
gene id: 456442:MBOO_RS06100
uniprot id: A7I7H7
names: Similarity
messages: Belongs to the DtxR/MntR family.

456442:MBOO RS03180
gene id: 456442:MBOO_RS03180
uniprot id: A7I5X1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

456442:MBOO RS08510
gene id: 456442:MBOO_RS08510
uniprot id: A7I8T7
names: Similarity
messages: Belongs to the UPF0047 family.

456442:MBOO RS06265
gene id: 456442:MBOO_RS06265
uniprot id: A7I7K8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

456442:MBOO RS07035
gene id: 456442:MBOO_RS07035
uniprot id: A7I804
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

456442:MBOO RS01070
gene id: 456442:MBOO_RS01070
uniprot id: A7I4S3
names: Similarity
messages: Belongs to the alpha-acetolactate decarboxylase family.

456442:MBOO RS00280
gene id: 456442:MBOO_RS00280
uniprot id: A7I4B9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

456442:MBOO RS01055
gene id: 456442:MBOO_RS01055
uniprot id: A7I4S0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

456442:MBOO RS10800
gene id: 456442:MBOO_RS10800
uniprot id: A7IA23
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS01595
gene id: 456442:MBOO_RS01595
uniprot id: A7I527
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

456442:MBOO RS02590
gene id: 456442:MBOO_RS02590
uniprot id: A7I5K8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

456442:MBOO RS08150
gene id: 456442:MBOO_RS08150
uniprot id: A7I8L3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

456442:MBOO RS07040
gene id: 456442:MBOO_RS07040
uniprot id: A7I805
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

456442:MBOO RS05665
gene id: 456442:MBOO_RS05665
uniprot id: A7I791
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

456442:MBOO RS01415
gene id: 456442:MBOO_RS01415
uniprot id: A7I4Z2
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

456442:MBOO RS02850
gene id: 456442:MBOO_RS02850
uniprot id: A7I5Q5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

456442:MBOO RS05960
gene id: 456442:MBOO_RS05960
uniprot id: A7I7E9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-98 inactivates the nitrogenase reductase and regulates nitrogenase activity.

456442:MBOO RS03635
gene id: 456442:MBOO_RS03635
uniprot id: A7I658
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

456442:MBOO RS12065
gene id: 456442:MBOO_RS12065
uniprot id: A7IAR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

456442:MBOO RS11590
gene id: 456442:MBOO_RS11590
uniprot id: A7IAH2
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

456442:MBOO RS04400
gene id: 456442:MBOO_RS04400
uniprot id: A7I6J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

456442:MBOO RS04510
gene id: 456442:MBOO_RS04510
uniprot id: A7I6L6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

456442:MBOO RS05885
gene id: 456442:MBOO_RS05885
uniprot id: A7I7D3
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS03395
gene id: 456442:MBOO_RS03395
uniprot id: A7I613
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

456442:MBOO RS10945
gene id: 456442:MBOO_RS10945
uniprot id: A7IA52
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

456442:MBOO RS11200
gene id: 456442:MBOO_RS11200
uniprot id: A7IAA2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

456442:MBOO RS00835
gene id: 456442:MBOO_RS00835
uniprot id: A7I4M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

456442:MBOO RS01345
gene id: 456442:MBOO_RS01345
uniprot id: A7I4X8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS00975
gene id: 456442:MBOO_RS00975
uniprot id: A7I4Q3
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS11500
gene id: 456442:MBOO_RS11500
uniprot id: A7IAF5
names: Similarity
messages: Belongs to the SAICAR synthetase family.

456442:MBOO RS03100
gene id: 456442:MBOO_RS03100
uniprot id: A7I5V5
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

456442:MBOO RS11165
gene id: 456442:MBOO_RS11165
uniprot id: A7IA95
names: Similarity
messages: Belongs to the thioesterase PaaI family.

456442:MBOO RS01230
gene id: 456442:MBOO_RS01230
uniprot id: A7I4V5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

456442:MBOO RS02205
gene id: 456442:MBOO_RS02205
uniprot id: A7I5D4
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS09780
gene id: 456442:MBOO_RS09780
uniprot id: A7I9I1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

456442:MBOO RS04425
gene id: 456442:MBOO_RS04425
uniprot id: A7I6K1
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS11480
gene id: 456442:MBOO_RS11480
uniprot id: A7IAF1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

456442:MBOO RS01330
gene id: 456442:MBOO_RS01330
uniprot id: A7I4X5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

456442:MBOO RS06865
gene id: 456442:MBOO_RS06865
uniprot id: A7I7X1
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

456442:MBOO RS01300
gene id: 456442:MBOO_RS01300
uniprot id: A7I4W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

456442:MBOO RS11850
gene id: 456442:MBOO_RS11850
uniprot id: A7IAM2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

456442:MBOO RS09485
gene id: 456442:MBOO_RS09485
uniprot id: A7I9C6
names: Similarity
messages: Belongs to the SDO1/SBDS family.

456442:MBOO RS03405
gene id: 456442:MBOO_RS03405
uniprot id: A7I615
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

456442:MBOO RS13280
gene id: 456442:MBOO_RS13280
uniprot id: A7IB27
names: Cofactor
messages: Binds 1 copper ion per subunit.

456442:MBOO RS10720
gene id: 456442:MBOO_RS10720
uniprot id: A7IA09
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

456442:MBOO RS10170
gene id: 456442:MBOO_RS10170
uniprot id: A7I9Q6
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

456442:MBOO RS06860
gene id: 456442:MBOO_RS06860
uniprot id: A7I7X0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

456442:MBOO RS03225
gene id: 456442:MBOO_RS03225
uniprot id: A7I5Y1
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

456442:MBOO RS05330
gene id: 456442:MBOO_RS05330
uniprot id: A7I727
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS00125
gene id: 456442:MBOO_RS00125
uniprot id: A7I488
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS05575
gene id: 456442:MBOO_RS05575
uniprot id: A7I774
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

456442:MBOO RS11555
gene id: 456442:MBOO_RS11555
uniprot id: A7IAG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

456442:MBOO RS11935
gene id: 456442:MBOO_RS11935
uniprot id: A7IAN8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

456442:MBOO RS10210
gene id: 456442:MBOO_RS10210
uniprot id: A7I9R4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

456442:MBOO RS11410
gene id: 456442:MBOO_RS11410
uniprot id: A7IAD8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

456442:MBOO RS08560
gene id: 456442:MBOO_RS08560
uniprot id: A7I8U7
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS10470
gene id: 456442:MBOO_RS10470
uniprot id: A7I9W3
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

456442:MBOO RS00740
gene id: 456442:MBOO_RS00740
uniprot id: A7I4K6
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Membrane

456442:MBOO RS11290
gene id: 456442:MBOO_RS11290
uniprot id: A7IAB9
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.

456442:MBOO RS06315
gene id: 456442:MBOO_RS06315
uniprot id: A7I7L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

456442:MBOO RS07565
gene id: 456442:MBOO_RS07565
uniprot id: A7I8A5
names: Similarity
messages: Belongs to the thioesterase PaaI family.

456442:MBOO RS00690
gene id: 456442:MBOO_RS00690
uniprot id: A7I4J7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

456442:MBOO RS05630
gene id: 456442:MBOO_RS05630
uniprot id: A7I785
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS03530
gene id: 456442:MBOO_RS03530
uniprot id: A7I637
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

456442:MBOO RS08550
gene id: 456442:MBOO_RS08550
uniprot id: A7I8U5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

456442:MBOO RS03580
gene id: 456442:MBOO_RS03580
uniprot id: A7I647
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

456442:MBOO RS00725
gene id: 456442:MBOO_RS00725
uniprot id: A7I4K3
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

456442:MBOO RS02965
gene id: 456442:MBOO_RS02965
uniprot id: A7I5S8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

456442:MBOO RS10410
gene id: 456442:MBOO_RS10410
uniprot id: A7I9V1
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

456442:MBOO RS10415
gene id: 456442:MBOO_RS10415
uniprot id: A7I9V2
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS00325
gene id: 456442:MBOO_RS00325
uniprot id: A7I4C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

456442:MBOO RS02255
gene id: 456442:MBOO_RS02255
uniprot id: A7I5E4
names: Similarity
messages: Belongs to the P(II) protein family.

456442:MBOO RS08800
gene id: 456442:MBOO_RS08800
uniprot id: A7I8Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

456442:MBOO RS08955
gene id: 456442:MBOO_RS08955
uniprot id: A7I925
names: Similarity
messages: Belongs to the thymidylate kinase family.

456442:MBOO RS03010
gene id: 456442:MBOO_RS03010
uniprot id: A7I5T7
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

456442:MBOO RS11140
gene id: 456442:MBOO_RS11140
uniprot id: A7IA90
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

456442:MBOO RS10685
gene id: 456442:MBOO_RS10685
uniprot id: A7IA02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

456442:MBOO RS10205
gene id: 456442:MBOO_RS10205
uniprot id: A7I9R3
names: Similarity
messages: Belongs to the UPF0179 family.

456442:MBOO RS03415
gene id: 456442:MBOO_RS03415
uniprot id: A7I617
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

456442:MBOO RS04500
gene id: 456442:MBOO_RS04500
uniprot id: A7I6L4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

456442:MBOO RS11835
gene id: 456442:MBOO_RS11835
uniprot id: A7IAL9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

456442:MBOO RS11710
gene id: 456442:MBOO_RS11710
uniprot id: A7IAJ5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

456442:MBOO RS00470
gene id: 456442:MBOO_RS00470
uniprot id: A7I4F6
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

456442:MBOO RS02790
gene id: 456442:MBOO_RS02790
uniprot id: A7I5P3
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

456442:MBOO RS02480
gene id: 456442:MBOO_RS02480
uniprot id: A7I5I8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.

456442:MBOO RS11600
gene id: 456442:MBOO_RS11600
uniprot id: A7IAH4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

456442:MBOO RS08555
gene id: 456442:MBOO_RS08555
uniprot id: A7I8U6
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS11945
gene id: 456442:MBOO_RS11945
uniprot id: A7IAP0
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS12830
gene id: 456442:MBOO_RS12830
uniprot id: A7IB58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

456442:MBOO RS10065
gene id: 456442:MBOO_RS10065
uniprot id: A7I9N8
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Part of the RNA polymerase complex.

456442:MBOO RS06750
gene id: 456442:MBOO_RS06750
uniprot id: A7I7U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

456442:MBOO RS06125
gene id: 456442:MBOO_RS06125
uniprot id: A7I7I2
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

456442:MBOO RS09825
gene id: 456442:MBOO_RS09825
uniprot id: A7I9J0
names: Similarity
messages: Belongs to the PDCD5 family.

456442:MBOO RS01255
gene id: 456442:MBOO_RS01255
uniprot id: A7I4W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

456442:MBOO RS12790
gene id: 456442:MBOO_RS12790
uniprot id: A7IB50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

456442:MBOO RS08540
gene id: 456442:MBOO_RS08540
uniprot id: A7I8U3
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS03410
gene id: 456442:MBOO_RS03410
uniprot id: A7I616
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

456442:MBOO RS09120
gene id: 456442:MBOO_RS09120
uniprot id: A7I958
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.

456442:MBOO RS05295
gene id: 456442:MBOO_RS05295
uniprot id: A7I720
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS09350
gene id: 456442:MBOO_RS09350
uniprot id: A7I9A1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

456442:MBOO RS08265
gene id: 456442:MBOO_RS08265
uniprot id: A7I8N6
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

456442:MBOO RS00845
gene id: 456442:MBOO_RS00845
uniprot id: A7I4M7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

456442:MBOO RS06615
gene id: 456442:MBOO_RS06615
uniprot id: A7I7S1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

456442:MBOO RS03030
gene id: 456442:MBOO_RS03030
uniprot id: A7I5U1
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

456442:MBOO RS04435
gene id: 456442:MBOO_RS04435
uniprot id: A7I6K3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Binds two Mg(2+) per subunit.
messages: Forms a ternary complex with MCM helicase and DNA.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

456442:MBOO RS09200
gene id: 456442:MBOO_RS09200
uniprot id: A7I974
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS08175
gene id: 456442:MBOO_RS08175
uniprot id: A7I8L8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

456442:MBOO RS04750
gene id: 456442:MBOO_RS04750
uniprot id: A7I6R3
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

456442:MBOO RS06630
gene id: 456442:MBOO_RS06630
uniprot id: A7I7S4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

456442:MBOO RS10335
gene id: 456442:MBOO_RS10335
uniprot id: A7I9T7
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

456442:MBOO RS06550
gene id: 456442:MBOO_RS06550
uniprot id: A7I7R0
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

456442:MBOO RS06350
gene id: 456442:MBOO_RS06350
uniprot id: A7I7M3
names: Caution
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

456442:MBOO RS06415
gene id: 456442:MBOO_RS06415
uniprot id: A7I7N6
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

456442:MBOO RS01195
gene id: 456442:MBOO_RS01195
uniprot id: A7I4U7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

456442:MBOO RS11285
gene id: 456442:MBOO_RS11285
uniprot id: A7IAB8
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

456442:MBOO RS05830
gene id: 456442:MBOO_RS05830
uniprot id: A7I7C2
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

456442:MBOO RS05810
gene id: 456442:MBOO_RS05810
uniprot id: A7I7B8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

456442:MBOO RS03520
gene id: 456442:MBOO_RS03520
uniprot id: A7I635
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

456442:MBOO RS01210
gene id: 456442:MBOO_RS01210
uniprot id: A7I4V1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

456442:MBOO RS11505
gene id: 456442:MBOO_RS11505
uniprot id: A7IAF6
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

456442:MBOO RS07230
gene id: 456442:MBOO_RS07230
uniprot id: A7I841
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

456442:MBOO RS09375
gene id: 456442:MBOO_RS09375
uniprot id: A7I9A6
names: Subunit
messages: Homotetramer.

456442:MBOO RS05570
gene id: 456442:MBOO_RS05570
uniprot id: A7I773
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

456442:MBOO RS05070
gene id: 456442:MBOO_RS05070
uniprot id: A7I6X7
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS05245
gene id: 456442:MBOO_RS05245
uniprot id: A7I710
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

456442:MBOO RS08155
gene id: 456442:MBOO_RS08155
uniprot id: A7I8L4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS10400
gene id: 456442:MBOO_RS10400
uniprot id: A7I9U9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

456442:MBOO RS03145
gene id: 456442:MBOO_RS03145
uniprot id: A7I5W4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Probably functions as a manganese efflux pump.

456442:MBOO RS06115
gene id: 456442:MBOO_RS06115
uniprot id: A7I7I0
names: Similarity
messages: Belongs to the band 7/mec-2 family.

456442:MBOO RS01635
gene id: 456442:MBOO_RS01635
uniprot id: A7I534
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS06805
gene id: 456442:MBOO_RS06805
uniprot id: A7I7V8
names: Similarity
messages: Belongs to the HypD family.

456442:MBOO RS12685
gene id: 456442:MBOO_RS12685
uniprot id: A7IB30
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

456442:MBOO RS06760
gene id: 456442:MBOO_RS06760
uniprot id: A7I7V0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

456442:MBOO RS03685
gene id: 456442:MBOO_RS03685
uniprot id: A7I668
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS08685
gene id: 456442:MBOO_RS08685
uniprot id: A7I8X1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS08945
gene id: 456442:MBOO_RS08945
uniprot id: A7I923
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

456442:MBOO RS12565
gene id: 456442:MBOO_RS12565
uniprot id: A7IB08
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS12725
gene id: 456442:MBOO_RS12725
uniprot id: A7IB37
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

456442:MBOO RS08240
gene id: 456442:MBOO_RS08240
uniprot id: A7I8N1
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

456442:MBOO RS01150
gene id: 456442:MBOO_RS01150
uniprot id: A7I4T9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

456442:MBOO RS06435
gene id: 456442:MBOO_RS06435
uniprot id: A7I7P0
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

456442:MBOO RS10225
gene id: 456442:MBOO_RS10225
uniprot id: A7I9R7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

456442:MBOO RS04815
gene id: 456442:MBOO_RS04815
uniprot id: A7I6S6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

456442:MBOO RS01380
gene id: 456442:MBOO_RS01380
uniprot id: A7I4Y5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS03135
gene id: 456442:MBOO_RS03135
uniprot id: A7I5W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0316 family.
messages: Cell membrane

456442:MBOO RS06440
gene id: 456442:MBOO_RS06440
uniprot id: A7I7P1
names: Similarity
messages: Belongs to the HMBS family.

456442:MBOO RS11565
gene id: 456442:MBOO_RS11565
uniprot id: A7IAG8
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

456442:MBOO RS07545
gene id: 456442:MBOO_RS07545
uniprot id: A7I8A1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

456442:MBOO RS00175
gene id: 456442:MBOO_RS00175
uniprot id: A7I498
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

456442:MBOO RS07535
gene id: 456442:MBOO_RS07535
uniprot id: A7I899
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
messages: Homodimer.

456442:MBOO RS00340
gene id: 456442:MBOO_RS00340
uniprot id: A7I4D1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

456442:MBOO RS01215
gene id: 456442:MBOO_RS01215
uniprot id: A7I4V2
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

456442:MBOO RS12460
gene id: 456442:MBOO_RS12460
uniprot id: A7IAY8
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS05325
gene id: 456442:MBOO_RS05325
uniprot id: A7I726
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

456442:MBOO RS09180
gene id: 456442:MBOO_RS09180
uniprot id: A7I970
names: Similarity
messages: Belongs to the UDPGP type 2 family.

456442:MBOO RS04765
gene id: 456442:MBOO_RS04765
uniprot id: A7I6R6
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

456442:MBOO RS03210
gene id: 456442:MBOO_RS03210
uniprot id: A7I5X8
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

456442:MBOO RS11635
gene id: 456442:MBOO_RS11635
uniprot id: A7IAI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

456442:MBOO RS07650
gene id: 456442:MBOO_RS07650
uniprot id: A7I8C2
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS09390
gene id: 456442:MBOO_RS09390
uniprot id: A7I9A9
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

456442:MBOO RS02960
gene id: 456442:MBOO_RS02960
uniprot id: A7I5S7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

456442:MBOO RS10115
gene id: 456442:MBOO_RS10115
uniprot id: A7I9P5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS00885
gene id: 456442:MBOO_RS00885
uniprot id: A7I4N5
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

456442:MBOO RS05715
gene id: 456442:MBOO_RS05715
uniprot id: A7I7A0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

456442:MBOO RS08760
gene id: 456442:MBOO_RS08760
uniprot id: A7I8Y6
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS11340
gene id: 456442:MBOO_RS11340
uniprot id: A7IAC9
names: Similarity
messages: Belongs to the UPF0305 family.

456442:MBOO RS05980
gene id: 456442:MBOO_RS05980
uniprot id: A7I7F3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Binds 1 [8Fe-7S] cluster per heterodimer.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

456442:MBOO RS08590
gene id: 456442:MBOO_RS08590
uniprot id: A7I8V2
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS00170
gene id: 456442:MBOO_RS00170
uniprot id: A7I497
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

456442:MBOO RS01285
gene id: 456442:MBOO_RS01285
uniprot id: A7I4W6
names: Similarity
messages: Belongs to the phosphohexose mutase family.

456442:MBOO RS09615
gene id: 456442:MBOO_RS09615
uniprot id: A7I9E9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

456442:MBOO RS07550
gene id: 456442:MBOO_RS07550
uniprot id: A7I8A2
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS10705
gene id: 456442:MBOO_RS10705
uniprot id: A7IA06
names: Similarity
messages: Belongs to the peptidase M3 family.

456442:MBOO RS05350
gene id: 456442:MBOO_RS05350
uniprot id: A7I731
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS05975
gene id: 456442:MBOO_RS05975
uniprot id: A7I7F2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

456442:MBOO RS01130
gene id: 456442:MBOO_RS01130
uniprot id: A7I4T5
names: Similarity
messages: Belongs to the TrpF family.

456442:MBOO RS05110
gene id: 456442:MBOO_RS05110
uniprot id: A7I6Y5
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS03815
gene id: 456442:MBOO_RS03815
uniprot id: A7I693
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

456442:MBOO RS03930
gene id: 456442:MBOO_RS03930
uniprot id: A7I6B3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

456442:MBOO RS03970
gene id: 456442:MBOO_RS03970
uniprot id: A7I6B9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

456442:MBOO RS00115
gene id: 456442:MBOO_RS00115
uniprot id: A7I486
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

456442:MBOO RS10810
gene id: 456442:MBOO_RS10810
uniprot id: A7IA25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

456442:MBOO RS08970
gene id: 456442:MBOO_RS08970
uniprot id: A7I928
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

456442:MBOO RS01220
gene id: 456442:MBOO_RS01220
uniprot id: A7I4V3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

456442:MBOO RS07155
gene id: 456442:MBOO_RS07155
uniprot id: A7I827
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhD family.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex.

456442:MBOO RS00990
gene id: 456442:MBOO_RS00990
uniprot id: A7I4Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

456442:MBOO RS10815
gene id: 456442:MBOO_RS10815
uniprot id: A7IA26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

456442:MBOO RS03230
gene id: 456442:MBOO_RS03230
uniprot id: A7I5Y2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

456442:MBOO RS11255
gene id: 456442:MBOO_RS11255
uniprot id: A7IAB3
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

456442:MBOO RS05380
gene id: 456442:MBOO_RS05380
uniprot id: A7I737
names: Similarity
messages: Belongs to the HsdR family.

456442:MBOO RS05440
gene id: 456442:MBOO_RS05440
uniprot id: A7I748
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

456442:MBOO RS06685
gene id: 456442:MBOO_RS06685
uniprot id: A7I7T6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

456442:MBOO RS11620
gene id: 456442:MBOO_RS11620
uniprot id: A7IAH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

456442:MBOO RS10870
gene id: 456442:MBOO_RS10870
uniprot id: A7IA37
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS00295
gene id: 456442:MBOO_RS00295
uniprot id: A7I4C2
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS02710
gene id: 456442:MBOO_RS02710
uniprot id: A7I5M8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
messages: Monomer.

456442:MBOO RS08730
gene id: 456442:MBOO_RS08730
uniprot id: A7I8Y0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

456442:MBOO RS02860
gene id: 456442:MBOO_RS02860
uniprot id: A7I5Q7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

456442:MBOO RS09775
gene id: 456442:MBOO_RS09775
uniprot id: A7I9I0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

456442:MBOO RS11585
gene id: 456442:MBOO_RS11585
uniprot id: A7IAH1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

456442:MBOO RS00645
gene id: 456442:MBOO_RS00645
uniprot id: A7I4I9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

456442:MBOO RS12160
gene id: 456442:MBOO_RS12160
uniprot id: A7IAS8
names: Similarity
messages: Belongs to the archaeal-type GPI family.

456442:MBOO RS09510
gene id: 456442:MBOO_RS09510
uniprot id: A7I9D1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

456442:MBOO RS07060
gene id: 456442:MBOO_RS07060
uniprot id: A7I809
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

456442:MBOO RS03950
gene id: 456442:MBOO_RS03950
uniprot id: A7I6B6
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

456442:MBOO RS11155
gene id: 456442:MBOO_RS11155
uniprot id: A7IA93
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

456442:MBOO RS10380
gene id: 456442:MBOO_RS10380
uniprot id: A7I9U5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS06355
gene id: 456442:MBOO_RS06355
uniprot id: A7I7M4
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

456442:MBOO RS04405
gene id: 456442:MBOO_RS04405
uniprot id: A7I6J7
names: Cofactor
names: Similarity
messages: Belongs to the GARS family.
messages: Binds 2 magnesium or manganese ions per subunit.

456442:MBOO RS03175
gene id: 456442:MBOO_RS03175
uniprot id: A7I5X0
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS12240
gene id: 456442:MBOO_RS12240
uniprot id: A7IAU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

456442:MBOO RS09475
gene id: 456442:MBOO_RS09475
uniprot id: A7I9C4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

456442:MBOO RS02785
gene id: 456442:MBOO_RS02785
uniprot id: A7I5P2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

456442:MBOO RS07860
gene id: 456442:MBOO_RS07860
uniprot id: A7I8G0
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

456442:MBOO RS00260
gene id: 456442:MBOO_RS00260
uniprot id: A7I4B5
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

456442:MBOO RS05565
gene id: 456442:MBOO_RS05565
uniprot id: A7I772
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

456442:MBOO RS12500
gene id: 456442:MBOO_RS12500
uniprot id: A7IAZ7
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

456442:MBOO RS04385
gene id: 456442:MBOO_RS04385
uniprot id: A7I6J3
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS03980
gene id: 456442:MBOO_RS03980
uniprot id: A7I6C1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

456442:MBOO RS08595
gene id: 456442:MBOO_RS08595
uniprot id: A7I8V3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

456442:MBOO RS00350
gene id: 456442:MBOO_RS00350
uniprot id: A7I4D3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

456442:MBOO RS01360
gene id: 456442:MBOO_RS01360
uniprot id: A7I4Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

456442:MBOO RS06130
gene id: 456442:MBOO_RS06130
uniprot id: A7I7I3
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

456442:MBOO RS11960
gene id: 456442:MBOO_RS11960
uniprot id: A7IAP2
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS07290
gene id: 456442:MBOO_RS07290
uniprot id: A7I852
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

456442:MBOO RS10765
gene id: 456442:MBOO_RS10765
uniprot id: A7IA16
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS02585
gene id: 456442:MBOO_RS02585
uniprot id: A7I5K7
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

456442:MBOO RS02845
gene id: 456442:MBOO_RS02845
uniprot id: A7I5Q4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

456442:MBOO RS02285
gene id: 456442:MBOO_RS02285
uniprot id: A7I5F1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

456442:MBOO RS00395
gene id: 456442:MBOO_RS00395
uniprot id: A7I4E2
names: Cofactor
messages: Binds 2 irons ions per subunit via 4 cysteine residues per iron.

456442:MBOO RS02685
gene id: 456442:MBOO_RS02685
uniprot id: A7I5M4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

456442:MBOO RS10010
gene id: 456442:MBOO_RS10010
uniprot id: A7I9M8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS11495
gene id: 456442:MBOO_RS11495
uniprot id: A7IAF4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: Consists of two subunits, CofG and CofH.

456442:MBOO RS07380
gene id: 456442:MBOO_RS07380
uniprot id: A7I869
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

456442:MBOO RS11745
gene id: 456442:MBOO_RS11745
uniprot id: A7IAK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

456442:MBOO RS09355
gene id: 456442:MBOO_RS09355
uniprot id: A7I9A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

456442:MBOO RS11545
gene id: 456442:MBOO_RS11545
uniprot id: A7IAG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).

456442:MBOO RS04645
gene id: 456442:MBOO_RS04645
uniprot id: A7I6P0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.
messages: The N-terminal domain is an archaea-specific tRNA-editing domain that hydrolyzes incorrectly charged L-seryl-tRNA(Thr). Catalysis of tRNA editing is performed by the charged tRNA itself.

456442:MBOO RS11180
gene id: 456442:MBOO_RS11180
uniprot id: A7IA98
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

456442:MBOO RS08320
gene id: 456442:MBOO_RS08320
uniprot id: A7I8P7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

456442:MBOO RS04505
gene id: 456442:MBOO_RS04505
uniprot id: A7I6L5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

456442:MBOO RS08215
gene id: 456442:MBOO_RS08215
uniprot id: A7I8M6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.

456442:MBOO RS03605
gene id: 456442:MBOO_RS03605
uniprot id: A7I652
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

456442:MBOO RS10365
gene id: 456442:MBOO_RS10365
uniprot id: A7I9U3
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

456442:MBOO RS04520
gene id: 456442:MBOO_RS04520
uniprot id: A7I6L8
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

456442:MBOO RS04375
gene id: 456442:MBOO_RS04375
uniprot id: A7I6J1
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

456442:MBOO RS12290
gene id: 456442:MBOO_RS12290
uniprot id: A7IAV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

456442:MBOO RS01510
gene id: 456442:MBOO_RS01510
uniprot id: A7I509
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

456442:MBOO RS03565
gene id: 456442:MBOO_RS03565
uniprot id: A7I644
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

456442:MBOO RS12680
gene id: 456442:MBOO_RS12680
uniprot id: A7IB29
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

456442:MBOO RS03590
gene id: 456442:MBOO_RS03590
uniprot id: A7I649
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS06085
gene id: 456442:MBOO_RS06085
uniprot id: A7I7H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

456442:MBOO RS09040
gene id: 456442:MBOO_RS09040
uniprot id: A7I942
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

456442:MBOO RS08395
gene id: 456442:MBOO_RS08395
uniprot id: A7I8R3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

456442:MBOO RS07270
gene id: 456442:MBOO_RS07270
uniprot id: A7I849
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

456442:MBOO RS02825
gene id: 456442:MBOO_RS02825
uniprot id: A7I5Q0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

456442:MBOO RS07595
gene id: 456442:MBOO_RS07595
uniprot id: A7I8B1
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

456442:MBOO RS02840
gene id: 456442:MBOO_RS02840
uniprot id: A7I5Q3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

456442:MBOO RS09330
gene id: 456442:MBOO_RS09330
uniprot id: A7I997
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

456442:MBOO RS00455
gene id: 456442:MBOO_RS00455
uniprot id: A7I4F3
names: Similarity
messages: Belongs to the ZPR1 family.

456442:MBOO RS10040
gene id: 456442:MBOO_RS10040
uniprot id: A7I9N3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

456442:MBOO RS00035
gene id: 456442:MBOO_RS00035
uniprot id: A7I470
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

456442:MBOO RS00315
gene id: 456442:MBOO_RS00315
uniprot id: A7I4C6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

456442:MBOO RS01125
gene id: 456442:MBOO_RS01125
uniprot id: A7I4T4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

456442:MBOO RS06770
gene id: 456442:MBOO_RS06770
uniprot id: A7I7V2
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS04495
gene id: 456442:MBOO_RS04495
uniprot id: A7I6L3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

456442:MBOO RS01235
gene id: 456442:MBOO_RS01235
uniprot id: A7I4V6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

456442:MBOO RS06765
gene id: 456442:MBOO_RS06765
uniprot id: A7I7V1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

456442:MBOO RS02580
gene id: 456442:MBOO_RS02580
uniprot id: A7I5K6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

456442:MBOO RS06820
gene id: 456442:MBOO_RS06820
uniprot id: A7I7W0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

456442:MBOO RS00940
gene id: 456442:MBOO_RS00940
uniprot id: A7I4P6
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

456442:MBOO RS10045
gene id: 456442:MBOO_RS10045
uniprot id: A7I9N4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

456442:MBOO RS02505
gene id: 456442:MBOO_RS02505
uniprot id: A7I5J3
names: Similarity
messages: Belongs to the AAA ATPase family.

456442:MBOO RS09850
gene id: 456442:MBOO_RS09850
uniprot id: A7I9J5
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS03400
gene id: 456442:MBOO_RS03400
uniprot id: A7I614
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

456442:MBOO RS00110
gene id: 456442:MBOO_RS00110
uniprot id: A7I485
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

456442:MBOO RS10125
gene id: 456442:MBOO_RS10125
uniprot id: A7I9P7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

456442:MBOO RS03955
gene id: 456442:MBOO_RS03955
uniprot id: A7I6B7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.

456442:MBOO RS04030
gene id: 456442:MBOO_RS04030
uniprot id: A7I6C9
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

456442:MBOO RS06300
gene id: 456442:MBOO_RS06300
uniprot id: A7I7L3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

456442:MBOO RS10540
gene id: 456442:MBOO_RS10540
uniprot id: A7I9X6
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

456442:MBOO RS04700
gene id: 456442:MBOO_RS04700
uniprot id: A7I6Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

456442:MBOO RS12155
gene id: 456442:MBOO_RS12155
uniprot id: A7IAS7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

456442:MBOO RS03810
gene id: 456442:MBOO_RS03810
uniprot id: A7I692
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

456442:MBOO RS01140
gene id: 456442:MBOO_RS01140
uniprot id: A7I4T7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

456442:MBOO RS12285
gene id: 456442:MBOO_RS12285
uniprot id: A7IAV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

456442:MBOO RS01325
gene id: 456442:MBOO_RS01325
uniprot id: A7I4X4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

456442:MBOO RS03055
gene id: 456442:MBOO_RS03055
uniprot id: A7I5U6
names: Similarity
messages: Belongs to the HdrB family.

456442:MBOO RS05805
gene id: 456442:MBOO_RS05805
uniprot id: A7I7B7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS09035
gene id: 456442:MBOO_RS09035
uniprot id: A7I941
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

456442:MBOO RS07050
gene id: 456442:MBOO_RS07050
uniprot id: A7I807
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

456442:MBOO RS03525
gene id: 456442:MBOO_RS03525
uniprot id: A7I636
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

456442:MBOO RS12035
gene id: 456442:MBOO_RS12035
uniprot id: A7IAQ6
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

456442:MBOO RS06460
gene id: 456442:MBOO_RS06460
uniprot id: A7I7P5
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

456442:MBOO RS10715
gene id: 456442:MBOO_RS10715
uniprot id: A7IA08
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

456442:MBOO RS00815
gene id: 456442:MBOO_RS00815
uniprot id: A7I4M1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).

456442:MBOO RS00580
gene id: 456442:MBOO_RS00580
uniprot id: A7I4H6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

456442:MBOO RS11570
gene id: 456442:MBOO_RS11570
uniprot id: A7IAG9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

456442:MBOO RS02490
gene id: 456442:MBOO_RS02490
uniprot id: A7I5J0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

456442:MBOO RS05785
gene id: 456442:MBOO_RS05785
uniprot id: A7I7B3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

456442:MBOO RS02885
gene id: 456442:MBOO_RS02885
uniprot id: A7I5R2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

456442:MBOO RS02875
gene id: 456442:MBOO_RS02875
uniprot id: A7I5R0
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

456442:MBOO RS03535
gene id: 456442:MBOO_RS03535
uniprot id: A7I638
names: Similarity
messages: Belongs to the acylphosphatase family.

456442:MBOO RS02865
gene id: 456442:MBOO_RS02865
uniprot id: A7I5Q8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

456442:MBOO RS05745
gene id: 456442:MBOO_RS05745
uniprot id: A7I7A6
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

456442:MBOO RS04270
gene id: 456442:MBOO_RS04270
uniprot id: A7I6H3
names: Similarity
messages: Belongs to the UPF0173 family.

456442:MBOO RS07540
gene id: 456442:MBOO_RS07540
uniprot id: A7I8A0
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

456442:MBOO RS03620
gene id: 456442:MBOO_RS03620
uniprot id: A7I655
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

456442:MBOO RS06090
gene id: 456442:MBOO_RS06090
uniprot id: A7I7H5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

456442:MBOO RS05095
gene id: 456442:MBOO_RS05095
uniprot id: A7I6Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family.
messages: Cell membrane
messages: Membrane

456442:MBOO RS11865
gene id: 456442:MBOO_RS11865
uniprot id: A7IAM5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

456442:MBOO RS10130
gene id: 456442:MBOO_RS10130
uniprot id: A7I9P8
names: Function
messages: Part of a potassium transport system.

456442:MBOO RS11045
gene id: 456442:MBOO_RS11045
uniprot id: A7IA72
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

456442:MBOO RS02780
gene id: 456442:MBOO_RS02780
uniprot id: A7I5P1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

456442:MBOO RS09155
gene id: 456442:MBOO_RS09155
uniprot id: A7I965
names: Similarity
messages: Belongs to the ABC transporter superfamily.

456442:MBOO RS00850
gene id: 456442:MBOO_RS00850
uniprot id: A7I4M8
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS03510
gene id: 456442:MBOO_RS03510
uniprot id: A7I633
names: Similarity
messages: Belongs to the UPF0285 family.

456442:MBOO RS05780
gene id: 456442:MBOO_RS05780
uniprot id: A7I7B2
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS12180
gene id: 456442:MBOO_RS12180
uniprot id: A7IAT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

456442:MBOO RS09720
gene id: 456442:MBOO_RS09720
uniprot id: A7I9G8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

456442:MBOO RS11780
gene id: 456442:MBOO_RS11780
uniprot id: A7IAK8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

456442:MBOO RS09490
gene id: 456442:MBOO_RS09490
uniprot id: A7I9C7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

456442:MBOO RS09810
gene id: 456442:MBOO_RS09810
uniprot id: A7I9I7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

456442:MBOO RS05835
gene id: 456442:MBOO_RS05835
uniprot id: A7I7C3
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

456442:MBOO RS05015
gene id: 456442:MBOO_RS05015
uniprot id: A7I6W6
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.

456442:MBOO RS06935
gene id: 456442:MBOO_RS06935
uniprot id: A7I7Y4
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

456442:MBOO RS07420
gene id: 456442:MBOO_RS07420
uniprot id: A7I877
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

456442:MBOO RS08070
gene id: 456442:MBOO_RS08070
uniprot id: A7I8J7
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS04755
gene id: 456442:MBOO_RS04755
uniprot id: A7I6R4
names: Similarity
messages: Belongs to the peptidase S49 family.

456442:MBOO RS01105
gene id: 456442:MBOO_RS01105
uniprot id: A7I4T1
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

456442:MBOO RS11130
gene id: 456442:MBOO_RS11130
uniprot id: A7IA88
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

456442:MBOO RS09905
gene id: 456442:MBOO_RS09905
uniprot id: A7I9K6
names: Similarity
messages: Belongs to the SUI1 family.

456442:MBOO RS10050
gene id: 456442:MBOO_RS10050
uniprot id: A7I9N5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

456442:MBOO RS11895
gene id: 456442:MBOO_RS11895
uniprot id: A7IAN0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

456442:MBOO RS12430
gene id: 456442:MBOO_RS12430
uniprot id: A7IAY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

456442:MBOO RS01120
gene id: 456442:MBOO_RS01120
uniprot id: A7I4T3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

456442:MBOO RS11530
gene id: 456442:MBOO_RS11530
uniprot id: A7IAG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

456442:MBOO RS09600
gene id: 456442:MBOO_RS09600
uniprot id: A7I9E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

456442:MBOO RS06045
gene id: 456442:MBOO_RS06045
uniprot id: A7I7G6
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

456442:MBOO RS06310
gene id: 456442:MBOO_RS06310
uniprot id: A7I7L5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

456442:MBOO RS06660
gene id: 456442:MBOO_RS06660
uniprot id: A7I7T1
names: Similarity
messages: Belongs to the UPF0280 family.

456442:MBOO RS06410
gene id: 456442:MBOO_RS06410
uniprot id: A7I7N5
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

456442:MBOO RS00020
gene id: 456442:MBOO_RS00020
uniprot id: A7I467
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

456442:MBOO RS04680
gene id: 456442:MBOO_RS04680
uniprot id: A7I6P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

456442:MBOO RS03385
gene id: 456442:MBOO_RS03385
uniprot id: A7I611
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

456442:MBOO RS05560
gene id: 456442:MBOO_RS05560
uniprot id: A7I771
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

456442:MBOO RS09800
gene id: 456442:MBOO_RS09800
uniprot id: A7I9I5
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

456442:MBOO RS02615
gene id: 456442:MBOO_RS02615
uniprot id: A7I5L2
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

456442:MBOO RS11560
gene id: 456442:MBOO_RS11560
uniprot id: A7IAG7
names: Similarity
messages: Belongs to the MEMO1 family.

456442:MBOO RS11755
gene id: 456442:MBOO_RS11755
uniprot id: A7IAK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

456442:MBOO RS01270
gene id: 456442:MBOO_RS01270
uniprot id: A7I4W3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

456442:MBOO RS11750
gene id: 456442:MBOO_RS11750
uniprot id: A7IAK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

456442:MBOO RS12260
gene id: 456442:MBOO_RS12260
uniprot id: A7IAU7
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

456442:MBOO RS05475
gene id: 456442:MBOO_RS05475
uniprot id: A7I755
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS04810
gene id: 456442:MBOO_RS04810
uniprot id: A7I6S5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

456442:MBOO RS07135
gene id: 456442:MBOO_RS07135
uniprot id: A7I823
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

456442:MBOO RS00410
gene id: 456442:MBOO_RS00410
uniprot id: A7I4E4
names: Similarity
messages: Belongs to the UPF0758 family.

456442:MBOO RS01010
gene id: 456442:MBOO_RS01010
uniprot id: A7I4R1
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

456442:MBOO RS02805
gene id: 456442:MBOO_RS02805
uniprot id: A7I5P6
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

456442:MBOO RS07310
gene id: 456442:MBOO_RS07310
uniprot id: A7I856
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Homodimer.

456442:MBOO RS02795
gene id: 456442:MBOO_RS02795
uniprot id: A7I5P4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

456442:MBOO RS06430
gene id: 456442:MBOO_RS06430
uniprot id: A7I7N9
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS08795
gene id: 456442:MBOO_RS08795
uniprot id: A7I8Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

456442:MBOO RS09990
gene id: 456442:MBOO_RS09990
uniprot id: A7I9M4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

456442:MBOO RS09770
gene id: 456442:MBOO_RS09770
uniprot id: A7I9H9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

456442:MBOO RS07385
gene id: 456442:MBOO_RS07385
uniprot id: A7I870
names: Similarity
messages: Belongs to the HypE family.

456442:MBOO RS03240
gene id: 456442:MBOO_RS03240
uniprot id: A7I5Y4
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

456442:MBOO RS02605
gene id: 456442:MBOO_RS02605
uniprot id: A7I5L0
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

456442:MBOO RS01090
gene id: 456442:MBOO_RS01090
uniprot id: A7I4S8
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS09165
gene id: 456442:MBOO_RS09165
uniprot id: A7I967
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS01620
gene id: 456442:MBOO_RS01620
uniprot id: A7I531
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

456442:MBOO RS02975
gene id: 456442:MBOO_RS02975
uniprot id: A7I5T0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

456442:MBOO RS08440
gene id: 456442:MBOO_RS08440
uniprot id: A7I8S2
names: Caution
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS00275
gene id: 456442:MBOO_RS00275
uniprot id: A7I4B8
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

456442:MBOO RS08655
gene id: 456442:MBOO_RS08655
uniprot id: A7I8W5
names: Similarity
messages: Belongs to the UPF0212 family.

456442:MBOO RS10315
gene id: 456442:MBOO_RS10315
uniprot id: A7I9T4
names: Subcellular Location Annotation
messages: Cell membrane

456442:MBOO RS07530
gene id: 456442:MBOO_RS07530
uniprot id: A7I898
names: Similarity
messages: Belongs to the UPF0305 family.

456442:MBOO RS03765
gene id: 456442:MBOO_RS03765
uniprot id: A7I683
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

456442:MBOO RS05940
gene id: 456442:MBOO_RS05940
uniprot id: A7I7E5
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

456442:MBOO RS12620
gene id: 456442:MBOO_RS12620
uniprot id: A7IB18
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

456442:MBOO RS00555
gene id: 456442:MBOO_RS00555
uniprot id: A7I4H1
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

456442:MBOO RS02970
gene id: 456442:MBOO_RS02970
uniprot id: A7I5S9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

456442:MBOO RS10630
gene id: 456442:MBOO_RS10630
uniprot id: A7I9Z3
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS00120
gene id: 456442:MBOO_RS00120
uniprot id: A7I487
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS12485
gene id: 456442:MBOO_RS12485
uniprot id: A7IAZ4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

456442:MBOO RS08805
gene id: 456442:MBOO_RS08805
uniprot id: A7I8Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

456442:MBOO RS02810
gene id: 456442:MBOO_RS02810
uniprot id: A7I5P7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

456442:MBOO RS06780
gene id: 456442:MBOO_RS06780
uniprot id: A7I7V4
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS09115
gene id: 456442:MBOO_RS09115
uniprot id: A7I957
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

456442:MBOO RS05160
gene id: 456442:MBOO_RS05160
uniprot id: A7I6Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

456442:MBOO RS11295
gene id: 456442:MBOO_RS11295
uniprot id: A7IAC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

456442:MBOO RS09910
gene id: 456442:MBOO_RS09910
uniprot id: A7I9K7
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS05700
gene id: 456442:MBOO_RS05700
uniprot id: A7I797
names: Similarity
messages: Belongs to the GroES chaperonin family.

456442:MBOO RS01280
gene id: 456442:MBOO_RS01280
uniprot id: A7I4W5
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

456442:MBOO RS04230
gene id: 456442:MBOO_RS04230
uniprot id: A7I6G8
names: Similarity
messages: Belongs to the UPF0147 family.

456442:MBOO RS10830
gene id: 456442:MBOO_RS10830
uniprot id: A7IA29
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS04580
gene id: 456442:MBOO_RS04580
uniprot id: A7I6M7
names: Similarity
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

456442:MBOO RS12265
gene id: 456442:MBOO_RS12265
uniprot id: A7IAU8
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

456442:MBOO RS02295
gene id: 456442:MBOO_RS02295
uniprot id: A7I5F3
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS08255
gene id: 456442:MBOO_RS08255
uniprot id: A7I8N4
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

456442:MBOO RS07260
gene id: 456442:MBOO_RS07260
uniprot id: A7I847
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS04530
gene id: 456442:MBOO_RS04530
uniprot id: A7I6M0
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

456442:MBOO RS11940
gene id: 456442:MBOO_RS11940
uniprot id: A7IAN9
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS00005
gene id: 456442:MBOO_RS00005
uniprot id: A7I464
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

456442:MBOO RS09555
gene id: 456442:MBOO_RS09555
uniprot id: A7I9D9
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

456442:MBOO RS10190
gene id: 456442:MBOO_RS10190
uniprot id: A7I9R0
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

456442:MBOO RS03265
gene id: 456442:MBOO_RS03265
uniprot id: A7I5Y9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

456442:MBOO RS09505
gene id: 456442:MBOO_RS09505
uniprot id: A7I9D0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

456442:MBOO RS11550
gene id: 456442:MBOO_RS11550
uniprot id: A7IAG5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

456442:MBOO RS06305
gene id: 456442:MBOO_RS06305
uniprot id: A7I7L4
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

456442:MBOO RS02955
gene id: 456442:MBOO_RS02955
uniprot id: A7I5S6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

456442:MBOO RS10950
gene id: 456442:MBOO_RS10950
uniprot id: A7IA53
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

456442:MBOO RS07460
gene id: 456442:MBOO_RS07460
uniprot id: A7I883
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS00040
gene id: 456442:MBOO_RS00040
uniprot id: A7I471
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

456442:MBOO RS09985
gene id: 456442:MBOO_RS09985
uniprot id: A7I9M3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

456442:MBOO RS03690
gene id: 456442:MBOO_RS03690
uniprot id: A7I669
names: Similarity
messages: Belongs to the acylphosphatase family.

456442:MBOO RS12810
gene id: 456442:MBOO_RS12810
uniprot id: A7IB54
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS07575
gene id: 456442:MBOO_RS07575
uniprot id: A7I8A7
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

456442:MBOO RS05705
gene id: 456442:MBOO_RS05705
uniprot id: A7I798
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

456442:MBOO RS04860
gene id: 456442:MBOO_RS04860
uniprot id: A7I6T5
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS08575
gene id: 456442:MBOO_RS08575
uniprot id: A7I8U9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

456442:MBOO RS04875
gene id: 456442:MBOO_RS04875
uniprot id: A7I6T8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

456442:MBOO RS02895
gene id: 456442:MBOO_RS02895
uniprot id: A7I5R4
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS10865
gene id: 456442:MBOO_RS10865
uniprot id: A7IA36
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

456442:MBOO RS06705
gene id: 456442:MBOO_RS06705
uniprot id: A7I7T9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

456442:MBOO RS06035
gene id: 456442:MBOO_RS06035
uniprot id: A7I7G4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

456442:MBOO RS03985
gene id: 456442:MBOO_RS03985
uniprot id: A7I6C2
names: Similarity
messages: Belongs to the UPF0111 family.

456442:MBOO RS03800
gene id: 456442:MBOO_RS03800
uniprot id: A7I690
names: Similarity
messages: Belongs to the class-I fumarase family.

456442:MBOO RS08355
gene id: 456442:MBOO_RS08355
uniprot id: A7I8Q3
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS09160
gene id: 456442:MBOO_RS09160
uniprot id: A7I966
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS09900
gene id: 456442:MBOO_RS09900
uniprot id: A7I9K5
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

456442:MBOO RS05390
gene id: 456442:MBOO_RS05390
uniprot id: A7I739
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

456442:MBOO RS02775
gene id: 456442:MBOO_RS02775
uniprot id: A7I5P0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

456442:MBOO RS03740
gene id: 456442:MBOO_RS03740
uniprot id: A7I679
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

456442:MBOO RS06450
gene id: 456442:MBOO_RS06450
uniprot id: A7I7P3
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

456442:MBOO RS01425
gene id: 456442:MBOO_RS01425
uniprot id: A7I4Z4
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

456442:MBOO RS00445
gene id: 456442:MBOO_RS00445
uniprot id: A7I4F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

456442:MBOO RS03615
gene id: 456442:MBOO_RS03615
uniprot id: A7I654
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS11425
gene id: 456442:MBOO_RS11425
uniprot id: A7IAE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

456442:MBOO RS08695
gene id: 456442:MBOO_RS08695
uniprot id: A7I8X3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS07985
gene id: 456442:MBOO_RS07985
uniprot id: A7I8I3
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

456442:MBOO RS03060
gene id: 456442:MBOO_RS03060
uniprot id: A7I5U7
names: Similarity
messages: Belongs to the HdrC family.

456442:MBOO RS08690
gene id: 456442:MBOO_RS08690
uniprot id: A7I8X2
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

456442:MBOO RS07265
gene id: 456442:MBOO_RS07265
uniprot id: A7I848
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

456442:MBOO RS03925
gene id: 456442:MBOO_RS03925
uniprot id: A7I6B2
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS01385
gene id: 456442:MBOO_RS01385
uniprot id: A7I4Y6
names: Similarity
messages: Belongs to the phosphoribulokinase family.

456442:MBOO RS10995
gene id: 456442:MBOO_RS10995
uniprot id: A7IA62
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS01025
gene id: 456442:MBOO_RS01025
uniprot id: A7I4R4
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

456442:MBOO RS02855
gene id: 456442:MBOO_RS02855
uniprot id: A7I5Q6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

456442:MBOO RS10980
gene id: 456442:MBOO_RS10980
uniprot id: A7IA59
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

456442:MBOO RS00570
gene id: 456442:MBOO_RS00570
uniprot id: A7I4H4
names: Similarity
messages: Belongs to the RuvC family.

456442:MBOO RS05485
gene id: 456442:MBOO_RS05485
uniprot id: A7I757
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

456442:MBOO RS11875
gene id: 456442:MBOO_RS11875
uniprot id: A7IAM7
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

456442:MBOO RS02550
gene id: 456442:MBOO_RS02550
uniprot id: A7I5K0
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

456442:MBOO RS08420
gene id: 456442:MBOO_RS08420
uniprot id: A7I8R8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456442:MBOO RS00270
gene id: 456442:MBOO_RS00270
uniprot id: A7I4B7
names: Similarity
messages: Belongs to the DMRL synthase family.

456442:MBOO RS06985
gene id: 456442:MBOO_RS06985
uniprot id: A7I7Z4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

456442:MBOO RS06880
gene id: 456442:MBOO_RS06880
uniprot id: A7I7X4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

456442:MBOO RS00745
gene id: 456442:MBOO_RS00745
uniprot id: A7I4K7
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

456442:MBOO RS05800
gene id: 456442:MBOO_RS05800
uniprot id: A7I7B6
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

456442:MBOO RS09565
gene id: 456442:MBOO_RS09565
uniprot id: A7I9E0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

456442:MBOO RS09255
gene id: 456442:MBOO_RS09255
uniprot id: A7I984
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS08345
gene id: 456442:MBOO_RS08345
uniprot id: A7I8Q2
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

456442:MBOO RS10790
gene id: 456442:MBOO_RS10790
uniprot id: A7IA21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

456442:MBOO RS02770
gene id: 456442:MBOO_RS02770
uniprot id: A7I5N9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

456442:MBOO RS02270
gene id: 456442:MBOO_RS02270
uniprot id: A7I5E7
names: Subcellular Location Annotation
messages: Membrane

456442:MBOO RS10650
gene id: 456442:MBOO_RS10650
uniprot id: A7I9Z7
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.