456163:AV541 RS09365
gene id: 456163:AV541_RS09365
uniprot id: A0A109QK29
names: Similarity
messages: Belongs to the transketolase family.

456163:AV541 RS05350
gene id: 456163:AV541_RS05350
uniprot id: A0A0X8D741
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Membrane

456163:AV541 RS07670
gene id: 456163:AV541_RS07670
uniprot id: A0A0X8D9J7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

456163:AV541 RS05015
gene id: 456163:AV541_RS05015
uniprot id: A0A0X8D8I2
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.

456163:AV541 RS05920
gene id: 456163:AV541_RS05920
uniprot id: A0A109QJU5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

456163:AV541 RS01570
gene id: 456163:AV541_RS01570
uniprot id: A0A109QE53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

456163:AV541 RS08695
gene id: 456163:AV541_RS08695
uniprot id: A0A0X8DDE6
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS03755
gene id: 456163:AV541_RS03755
uniprot id: A0A109QF12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

456163:AV541 RS03595
gene id: 456163:AV541_RS03595
uniprot id: A0A0X8D8K6
names: Similarity
messages: Belongs to the ComB family.

456163:AV541 RS06395
gene id: 456163:AV541_RS06395
uniprot id: A0A0X8D7V5
names: Similarity
messages: Belongs to the Nudix hydrolase family.

456163:AV541 RS05540
gene id: 456163:AV541_RS05540
uniprot id: A0A109QJR4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

456163:AV541 RS07230
gene id: 456163:AV541_RS07230
uniprot id: H7GG28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

456163:AV541 RS00255
gene id: 456163:AV541_RS00255
uniprot id: A0A0X8D6K7
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS05305
gene id: 456163:AV541_RS05305
uniprot id: A0A0X8DCP5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

456163:AV541 RS04240
gene id: 456163:AV541_RS04240
uniprot id: A0A109QJQ0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS07870
gene id: 456163:AV541_RS07870
uniprot id: A0A120HTA9
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

456163:AV541 RS04745
gene id: 456163:AV541_RS04745
uniprot id: A0A0X8D7V8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS05505
gene id: 456163:AV541_RS05505
uniprot id: H7GGE9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flotillin-like FloA family.
messages: Cell membrane
messages: Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.
messages: Homooligomerizes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane raft

456163:AV541 RS08810
gene id: 456163:AV541_RS08810
uniprot id: A0A0X8DDE8
names: Similarity
messages: Belongs to the UbiD family.

456163:AV541 RS00605
gene id: 456163:AV541_RS00605
uniprot id: A0A0X8D7S4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

456163:AV541 RS10120
gene id: 456163:AV541_RS10120
uniprot id: A0A109QEW3
names: Similarity
messages: Belongs to the AlaDH/PNT family.

456163:AV541 RS05460
gene id: 456163:AV541_RS05460
uniprot id: A0A0X8D751
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

456163:AV541 RS06275
gene id: 456163:AV541_RS06275
uniprot id: A0A109QJT5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

456163:AV541 RS01125
gene id: 456163:AV541_RS01125
uniprot id: A0A0X8D6H4
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS00975
gene id: 456163:AV541_RS00975
uniprot id: A0A0X8DC05
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS00865
gene id: 456163:AV541_RS00865
uniprot id: H7GIT9
names: Similarity
messages: Belongs to the PspA/IM30 family.

456163:AV541 RS00640
gene id: 456163:AV541_RS00640
uniprot id: H7GIZ4
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

456163:AV541 RS09300
gene id: 456163:AV541_RS09300
uniprot id: A0A120HTD0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

456163:AV541 RS04665
gene id: 456163:AV541_RS04665
uniprot id: A0A0X8D8V1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

456163:AV541 RS07350
gene id: 456163:AV541_RS07350
uniprot id: A0A109QG76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

456163:AV541 RS08560
gene id: 456163:AV541_RS08560
uniprot id: A0A0X8D8K2
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

456163:AV541 RS04190
gene id: 456163:AV541_RS04190
uniprot id: A0A0X8D7B2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

456163:AV541 RS00590
gene id: 456163:AV541_RS00590
uniprot id: A0A0X8D6Y9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

456163:AV541 RS08070
gene id: 456163:AV541_RS08070
uniprot id: A0A0X8DDD1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

456163:AV541 RS05570
gene id: 456163:AV541_RS05570
uniprot id: A0A0X8D7N0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

456163:AV541 RS02390
gene id: 456163:AV541_RS02390
uniprot id: H7GHT9
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

456163:AV541 RS05075
gene id: 456163:AV541_RS05075
uniprot id: A0A0X8D920
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

456163:AV541 RS10125
gene id: 456163:AV541_RS10125
uniprot id: H7GDK1
names: Function
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

456163:AV541 RS00395
gene id: 456163:AV541_RS00395
uniprot id: A0A109QJG3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

456163:AV541 RS02365
gene id: 456163:AV541_RS02365
uniprot id: H7GHU4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

456163:AV541 RS07705
gene id: 456163:AV541_RS07705
uniprot id: H7GFJ9
names: Similarity
messages: Belongs to the universal stress protein A family.

456163:AV541 RS09305
gene id: 456163:AV541_RS09305
uniprot id: A0A0X8D853
names: Similarity
messages: Belongs to the peptidase S1C family.

456163:AV541 RS02585
gene id: 456163:AV541_RS02585
uniprot id: A0A0X8D6W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

456163:AV541 RS07020
gene id: 456163:AV541_RS07020
uniprot id: A0A109QEM4
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

456163:AV541 RS01505
gene id: 456163:AV541_RS01505
uniprot id: H7GIH9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS05565
gene id: 456163:AV541_RS05565
uniprot id: A0A0X8D759
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

456163:AV541 RS08815
gene id: 456163:AV541_RS08815
uniprot id: A0A109QES2
names: Similarity
messages: Belongs to the UPF0102 family.

456163:AV541 RS01890
gene id: 456163:AV541_RS01890
uniprot id: A0A109QEV6
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

456163:AV541 RS10585
gene id: 456163:AV541_RS10585
uniprot id: H7GES2
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

456163:AV541 RS07865
gene id: 456163:AV541_RS07865
uniprot id: A0A120HTB4
names: Subcellular Location Annotation
messages: Cytoplasm

456163:AV541 RS09360
gene id: 456163:AV541_RS09360
uniprot id: A0A0X8D9X5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

456163:AV541 RS03650
gene id: 456163:AV541_RS03650
uniprot id: A0A109QJM0
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

456163:AV541 RS01845
gene id: 456163:AV541_RS01845
uniprot id: H7GI40
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

456163:AV541 RS06185
gene id: 456163:AV541_RS06185
uniprot id: A0A0X8D7B8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

456163:AV541 RS08520
gene id: 456163:AV541_RS08520
uniprot id: H7GF55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

456163:AV541 RS10565
gene id: 456163:AV541_RS10565
uniprot id: H7GER8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family.
messages: Cell membrane
messages: Membrane

456163:AV541 RS02505
gene id: 456163:AV541_RS02505
uniprot id: A0A0X8D747
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.

456163:AV541 RS00480
gene id: 456163:AV541_RS00480
uniprot id: A0A109QJS3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

456163:AV541 RS01265
gene id: 456163:AV541_RS01265
uniprot id: A0A0X8D746
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
messages: Catalyzes the NADPH-dependent reduction of [LysW]-aminoadipate 6-phosphate to yield [LysW]-aminoadipate 6-semialdehyde.
messages: Cytoplasm

456163:AV541 RS08875
gene id: 456163:AV541_RS08875
uniprot id: A0A0X8D8U6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

456163:AV541 RS00110
gene id: 456163:AV541_RS00110
uniprot id: A0A0X8D5T7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

456163:AV541 RS08015
gene id: 456163:AV541_RS08015
uniprot id: A0A0X8D899
names: Similarity
messages: Belongs to the aspartokinase family.

456163:AV541 RS00655
gene id: 456163:AV541_RS00655
uniprot id: H7GIZ1
names: Similarity
messages: Belongs to the UPF0166 family.

456163:AV541 RS02310
gene id: 456163:AV541_RS02310
uniprot id: H7GHV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

456163:AV541 RS02430
gene id: 456163:AV541_RS02430
uniprot id: H7GI57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

456163:AV541 RS06620
gene id: 456163:AV541_RS06620
uniprot id: H7GFZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

456163:AV541 RS09405
gene id: 456163:AV541_RS09405
uniprot id: H7GE70
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

456163:AV541 RS01325
gene id: 456163:AV541_RS01325
uniprot id: H7GIL2
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

456163:AV541 RS03095
gene id: 456163:AV541_RS03095
uniprot id: A0A109QEA2
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

456163:AV541 RS03705
gene id: 456163:AV541_RS03705
uniprot id: A0A0X8D7E8
names: Similarity
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.

456163:AV541 RS02340
gene id: 456163:AV541_RS02340
uniprot id: H7GHU9
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

456163:AV541 RS10100
gene id: 456163:AV541_RS10100
uniprot id: A0A0X8DDN2
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

456163:AV541 RS02250
gene id: 456163:AV541_RS02250
uniprot id: A0A0X8D7C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

456163:AV541 RS02370
gene id: 456163:AV541_RS02370
uniprot id: A0A109QJK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

456163:AV541 RS04935
gene id: 456163:AV541_RS04935
uniprot id: A0A0X8D714
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

456163:AV541 RS00140
gene id: 456163:AV541_RS00140
uniprot id: A0A0X8DDP0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

456163:AV541 RS02025
gene id: 456163:AV541_RS02025
uniprot id: A0A0X8D691
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

456163:AV541 RS10615
gene id: 456163:AV541_RS10615
uniprot id: A0A120HTG1
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

456163:AV541 RS01535
gene id: 456163:AV541_RS01535
uniprot id: A0A0X8D821
names: Cofactor
messages: Can also use Mn(2+) ion.

456163:AV541 RS03245
gene id: 456163:AV541_RS03245
uniprot id: A0A120HT39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0073 (Hly-III) family.
messages: Membrane

456163:AV541 RS04815
gene id: 456163:AV541_RS04815
uniprot id: H7GEI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

456163:AV541 RS10660
gene id: 456163:AV541_RS10660
uniprot id: A0A0X8D9G2
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

456163:AV541 RS05265
gene id: 456163:AV541_RS05265
uniprot id: A0A0X8D841
names: Similarity
messages: Belongs to the BMP lipoprotein family.

456163:AV541 RS03520
gene id: 456163:AV541_RS03520
uniprot id: A0A109QIE0
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

456163:AV541 RS01525
gene id: 456163:AV541_RS01525
uniprot id: A0A0X8D761
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

456163:AV541 RS07830
gene id: 456163:AV541_RS07830
uniprot id: A0A0X8D8E2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

456163:AV541 RS00790
gene id: 456163:AV541_RS00790
uniprot id: A0A0X8D5Y7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

456163:AV541 RS07155
gene id: 456163:AV541_RS07155
uniprot id: A0A0X8D7J9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

456163:AV541 RS05065
gene id: 456163:AV541_RS05065
uniprot id: A0A0X8D999
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS00050
gene id: 456163:AV541_RS00050
uniprot id: A0A0X8D807
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

456163:AV541 RS03270
gene id: 456163:AV541_RS03270
uniprot id: H7GHE2
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

456163:AV541 RS02440
gene id: 456163:AV541_RS02440
uniprot id: A0A109QE78
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

456163:AV541 RS05500
gene id: 456163:AV541_RS05500
uniprot id: A0A0X8D9C8
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS07665
gene id: 456163:AV541_RS07665
uniprot id: A0A0X8D8H5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS07840
gene id: 456163:AV541_RS07840
uniprot id: A0A0X8D9K2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS04005
gene id: 456163:AV541_RS04005
uniprot id: A0A0X8D7T5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

456163:AV541 RS01155
gene id: 456163:AV541_RS01155
uniprot id: H7GIN8
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

456163:AV541 RS09080
gene id: 456163:AV541_RS09080
uniprot id: A0A0X8D825
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

456163:AV541 RS10800
gene id: 456163:AV541_RS10800
uniprot id: A0A0X8DAB2
names: Similarity
messages: Belongs to the ParB family.

456163:AV541 RS06510
gene id: 456163:AV541_RS06510
uniprot id: A0A0X8D9K1
names: Similarity
messages: Belongs to the Lgt family.

456163:AV541 RS07315
gene id: 456163:AV541_RS07315
uniprot id: H7GG14
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

456163:AV541 RS10180
gene id: 456163:AV541_RS10180
uniprot id: A0A0X8DA10
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

456163:AV541 RS02280
gene id: 456163:AV541_RS02280
uniprot id: A0A0X8DC73
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

456163:AV541 RS05520
gene id: 456163:AV541_RS05520
uniprot id: A0A109QJT7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

456163:AV541 RS07390
gene id: 456163:AV541_RS07390
uniprot id: A0A0X8D8N1
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS09265
gene id: 456163:AV541_RS09265
uniprot id: A0A109QIT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 15 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

456163:AV541 RS10275
gene id: 456163:AV541_RS10275
uniprot id: A0A120HTF4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS02765
gene id: 456163:AV541_RS02765
uniprot id: A0A0X8D6Y6
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

456163:AV541 RS06825
gene id: 456163:AV541_RS06825
uniprot id: A0A0X8D7G9
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

456163:AV541 RS04850
gene id: 456163:AV541_RS04850
uniprot id: A0A0X8D6Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
messages: Cytoplasm
messages: Homodimer.

456163:AV541 RS08480
gene id: 456163:AV541_RS08480
uniprot id: A0A109QER3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

456163:AV541 RS03455
gene id: 456163:AV541_RS03455
uniprot id: A0A0X8D6M4
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS05645
gene id: 456163:AV541_RS05645
uniprot id: A0A109QF73
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

456163:AV541 RS02730
gene id: 456163:AV541_RS02730
uniprot id: A0A109QE91
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

456163:AV541 RS10140
gene id: 456163:AV541_RS10140
uniprot id: A0A0X8D8F3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

456163:AV541 RS09745
gene id: 456163:AV541_RS09745
uniprot id: H7GE07
names: Subunit
messages: Homodimer.

456163:AV541 RS04860
gene id: 456163:AV541_RS04860
uniprot id: A0A0X8D7W5
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

456163:AV541 RS02315
gene id: 456163:AV541_RS02315
uniprot id: A0A0X8D6B2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

456163:AV541 RS03565
gene id: 456163:AV541_RS03565
uniprot id: A0A0X8D6M1
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

456163:AV541 RS09685
gene id: 456163:AV541_RS09685
uniprot id: H7GE18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

456163:AV541 RS10665
gene id: 456163:AV541_RS10665
uniprot id: A0A0X8DAA3
names: Similarity
messages: Belongs to the argonaute family. Long pAgo subfamily.

456163:AV541 RS06215
gene id: 456163:AV541_RS06215
uniprot id: A0A0X8D8B9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

456163:AV541 RS04085
gene id: 456163:AV541_RS04085
uniprot id: H7GGZ6
names: Similarity
messages: Belongs to the leucine-binding protein family.

456163:AV541 RS00675
gene id: 456163:AV541_RS00675
uniprot id: H7GIY7
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

456163:AV541 RS07690
gene id: 456163:AV541_RS07690
uniprot id: H7GFK3
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

456163:AV541 RS02595
gene id: 456163:AV541_RS02595
uniprot id: H7GHR2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS02360
gene id: 456163:AV541_RS02360
uniprot id: A0A0X8DC78
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

456163:AV541 RS04405
gene id: 456163:AV541_RS04405
uniprot id: A0A109QFY6
names: Similarity
messages: Belongs to the disproportionating enzyme family.

456163:AV541 RS00795
gene id: 456163:AV541_RS00795
uniprot id: A0A0X8D6E6
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

456163:AV541 RS04360
gene id: 456163:AV541_RS04360
uniprot id: A0A0X8D8W4
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.

456163:AV541 RS05415
gene id: 456163:AV541_RS05415
uniprot id: A0A109QIH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Membrane

456163:AV541 RS06460
gene id: 456163:AV541_RS06460
uniprot id: A0A120HT93
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS00170
gene id: 456163:AV541_RS00170
uniprot id: H7GDF6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

456163:AV541 RS01210
gene id: 456163:AV541_RS01210
uniprot id: A0A109QE42
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS06440
gene id: 456163:AV541_RS06440
uniprot id: A0A0X8DD01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

456163:AV541 RS08125
gene id: 456163:AV541_RS08125
uniprot id: A0A0X8D7T2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.

456163:AV541 RS04680
gene id: 456163:AV541_RS04680
uniprot id: A0A0X8D8Z1
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

456163:AV541 RS05885
gene id: 456163:AV541_RS05885
uniprot id: A0A0X8D9E6
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS06410
gene id: 456163:AV541_RS06410
uniprot id: A0A0X8D8D8
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

456163:AV541 RS00665
gene id: 456163:AV541_RS00665
uniprot id: H7GIY9
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

456163:AV541 RS08060
gene id: 456163:AV541_RS08060
uniprot id: A0A0X8D9M0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

456163:AV541 RS06630
gene id: 456163:AV541_RS06630
uniprot id: A0A109QK58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

456163:AV541 RS04105
gene id: 456163:AV541_RS04105
uniprot id: A0A0X8D7V6
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

456163:AV541 RS09500
gene id: 456163:AV541_RS09500
uniprot id: A0A109QGC9
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

456163:AV541 RS00810
gene id: 456163:AV541_RS00810
uniprot id: A0A0X8D6W8
names: Similarity
messages: Belongs to the GSP E family.

456163:AV541 RS05000
gene id: 456163:AV541_RS05000
uniprot id: A0A109QEG3
names: Similarity
messages: Belongs to the peptidase M29 family.

456163:AV541 RS05755
gene id: 456163:AV541_RS05755
uniprot id: A0A0X8DA83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate.
messages: Cytoplasm

456163:AV541 RS06165
gene id: 456163:AV541_RS06165
uniprot id: A0A120HT85
names: Similarity
messages: Belongs to the MEMO1 family.

456163:AV541 RS01270
gene id: 456163:AV541_RS01270
uniprot id: A0A0X8D803
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. LysZ subfamily.
messages: Catalyzes the phosphorylation of LysW-gamma-alpha-aminoadipate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS01170
gene id: 456163:AV541_RS01170
uniprot id: A0A109QJT8
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS09950
gene id: 456163:AV541_RS09950
uniprot id: A0A0X8DA31
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

456163:AV541 RS01475
gene id: 456163:AV541_RS01475
uniprot id: A0A109QJI2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

456163:AV541 RS03865
gene id: 456163:AV541_RS03865
uniprot id: A0A120HT50
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS03525
gene id: 456163:AV541_RS03525
uniprot id: A0A0X8DCB9
names: Similarity
messages: Belongs to the peptidase C56 family.

456163:AV541 RS03290
gene id: 456163:AV541_RS03290
uniprot id: A0A0X8D8W0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS03075
gene id: 456163:AV541_RS03075
uniprot id: A0A109QJY1
names: Cofactor
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

456163:AV541 RS08550
gene id: 456163:AV541_RS08550
uniprot id: A0A0X8D9L4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

456163:AV541 RS00385
gene id: 456163:AV541_RS00385
uniprot id: H7GDL3
names: Similarity
messages: Belongs to the peptidase S8 family.

456163:AV541 RS03550
gene id: 456163:AV541_RS03550
uniprot id: A0A120HT46
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

456163:AV541 RS04305
gene id: 456163:AV541_RS04305
uniprot id: A0A109QJN0
names: Similarity
messages: Belongs to the UPF0173 family.

456163:AV541 RS02300
gene id: 456163:AV541_RS02300
uniprot id: A0A120HT24
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

456163:AV541 RS05375
gene id: 456163:AV541_RS05375
uniprot id: A0A0X8D852
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

456163:AV541 RS00125
gene id: 456163:AV541_RS00125
uniprot id: A0A0X8D6R5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

456163:AV541 RS10380
gene id: 456163:AV541_RS10380
uniprot id: H7GI81
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

456163:AV541 RS01875
gene id: 456163:AV541_RS01875
uniprot id: A0A109QE59
names: Similarity
messages: Belongs to the GSP E family.

456163:AV541 RS06295
gene id: 456163:AV541_RS06295
uniprot id: A0A0X8D7T7
names: Similarity
messages: Belongs to the peptidase C15 family.

456163:AV541 RS04040
gene id: 456163:AV541_RS04040
uniprot id: A0A109QK07
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS05150
gene id: 456163:AV541_RS05150
uniprot id: A0A0X8D832
names: Similarity
messages: Belongs to the asp23 family.

456163:AV541 RS09310
gene id: 456163:AV541_RS09310
uniprot id: A0A0X8D846
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS04660
gene id: 456163:AV541_RS04660
uniprot id: A0A0X8D7Z3
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

456163:AV541 RS02380
gene id: 456163:AV541_RS02380
uniprot id: H7GHU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

456163:AV541 RS03090
gene id: 456163:AV541_RS03090
uniprot id: A0A109QEA1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

456163:AV541 RS03785
gene id: 456163:AV541_RS03785
uniprot id: H7GH45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

456163:AV541 RS04115
gene id: 456163:AV541_RS04115
uniprot id: A0A0X8D927
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

456163:AV541 RS01630
gene id: 456163:AV541_RS01630
uniprot id: A0A0X8D6V9
names: Function
names: Similarity
messages: Belongs to the RNase Y family.
messages: Endoribonuclease that initiates mRNA decay.

456163:AV541 RS04820
gene id: 456163:AV541_RS04820
uniprot id: A0A120HT65
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

456163:AV541 RS03210
gene id: 456163:AV541_RS03210
uniprot id: A0A120HT41
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

456163:AV541 RS10065
gene id: 456163:AV541_RS10065
uniprot id: A0A0X8D902
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 7 family.
messages: Homodimer.
messages: Part of the tripartite ATP-independent periplasmic (TRAP) transport system.
messages: Periplasm

456163:AV541 RS07535
gene id: 456163:AV541_RS07535
uniprot id: A0A109QK37
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

456163:AV541 RS06415
gene id: 456163:AV541_RS06415
uniprot id: A0A0X8D981
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

456163:AV541 RS01090
gene id: 456163:AV541_RS01090
uniprot id: A0A120HT08
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

456163:AV541 RS06425
gene id: 456163:AV541_RS06425
uniprot id: A0A0X8D833
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

456163:AV541 RS09855
gene id: 456163:AV541_RS09855
uniprot id: H7GDY7
names: Similarity
messages: Belongs to the AOR/FOR family.

456163:AV541 RS10015
gene id: 456163:AV541_RS10015
uniprot id: A0A0X8D8C5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

456163:AV541 RS05590
gene id: 456163:AV541_RS05590
uniprot id: H7GGD2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

456163:AV541 RS09760
gene id: 456163:AV541_RS09760
uniprot id: A0A0X8DA13
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

456163:AV541 RS03155
gene id: 456163:AV541_RS03155
uniprot id: A0A0X8D7K5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

456163:AV541 RS06870
gene id: 456163:AV541_RS06870
uniprot id: A0A109QJW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

456163:AV541 RS08665
gene id: 456163:AV541_RS08665
uniprot id: A0A0X8DA20
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

456163:AV541 RS04030
gene id: 456163:AV541_RS04030
uniprot id: A0A0X8D8T3
names: Similarity
messages: Belongs to the citrate synthase family.

456163:AV541 RS10625
gene id: 456163:AV541_RS10625
uniprot id: A0A0X8D8Q0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

456163:AV541 RS01070
gene id: 456163:AV541_RS01070
uniprot id: A0A0X8D812
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS07365
gene id: 456163:AV541_RS07365
uniprot id: A0A0X8D7L8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

456163:AV541 RS02320
gene id: 456163:AV541_RS02320
uniprot id: A0A0X8D6T4
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

456163:AV541 RS01625
gene id: 456163:AV541_RS01625
uniprot id: H7GIF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

456163:AV541 RS08660
gene id: 456163:AV541_RS08660
uniprot id: A0A0X8D9M2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

456163:AV541 RS05205
gene id: 456163:AV541_RS05205
uniprot id: A0A109QJQ6
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

456163:AV541 RS04095
gene id: 456163:AV541_RS04095
uniprot id: A0A0X8D7Q7
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

456163:AV541 RS02965
gene id: 456163:AV541_RS02965
uniprot id: A0A109QJL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

456163:AV541 RS00150
gene id: 456163:AV541_RS00150
uniprot id: A0A0X8D822
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

456163:AV541 RS02290
gene id: 456163:AV541_RS02290
uniprot id: A0A120HT26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

456163:AV541 RS09070
gene id: 456163:AV541_RS09070
uniprot id: H7GEC5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS05440
gene id: 456163:AV541_RS05440
uniprot id: A0A0X8D9B4
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

456163:AV541 RS05055
gene id: 456163:AV541_RS05055
uniprot id: A0A0X8D823
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

456163:AV541 RS03360
gene id: 456163:AV541_RS03360
uniprot id: A0A0X8D6L7
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

456163:AV541 RS02335
gene id: 456163:AV541_RS02335
uniprot id: H7GHV0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

456163:AV541 RS04355
gene id: 456163:AV541_RS04355
uniprot id: A0A0X8D7K6
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.

456163:AV541 RS05470
gene id: 456163:AV541_RS05470
uniprot id: A0A0X8D808
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

456163:AV541 RS04160
gene id: 456163:AV541_RS04160
uniprot id: A0A120HT54
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

456163:AV541 RS08610
gene id: 456163:AV541_RS08610
uniprot id: A0A120HTC0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

456163:AV541 RS08675
gene id: 456163:AV541_RS08675
uniprot id: A0A0X8D9R1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS04245
gene id: 456163:AV541_RS04245
uniprot id: A0A109QKA5
names: Similarity
messages: Belongs to the peptidase S41A family.

456163:AV541 RS07025
gene id: 456163:AV541_RS07025
uniprot id: A0A109QFA5
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS02905
gene id: 456163:AV541_RS02905
uniprot id: A0A0X8D7I8
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

456163:AV541 RS04165
gene id: 456163:AV541_RS04165
uniprot id: A0A120HT56
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS05895
gene id: 456163:AV541_RS05895
uniprot id: A0A0X8D7Y6
names: Similarity
messages: Belongs to the extradiol ring-cleavage dioxygenase family.

456163:AV541 RS05975
gene id: 456163:AV541_RS05975
uniprot id: A0A0X8D7R0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

456163:AV541 RS01860
gene id: 456163:AV541_RS01860
uniprot id: H7GI37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

456163:AV541 RS03615
gene id: 456163:AV541_RS03615
uniprot id: A0A0X8D8P3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

456163:AV541 RS09705
gene id: 456163:AV541_RS09705
uniprot id: A0A109QK15
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

456163:AV541 RS01220
gene id: 456163:AV541_RS01220
uniprot id: A0A109QE43
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS07510
gene id: 456163:AV541_RS07510
uniprot id: A0A0X8D8I6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

456163:AV541 RS00900
gene id: 456163:AV541_RS00900
uniprot id: A0A0X8D5Z8
names: Similarity
messages: Belongs to the pyruvate kinase family.

456163:AV541 RS01230
gene id: 456163:AV541_RS01230
uniprot id: H7GIM7
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

456163:AV541 RS07040
gene id: 456163:AV541_RS07040
uniprot id: H7GFR5
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

456163:AV541 RS02395
gene id: 456163:AV541_RS02395
uniprot id: A0A0X8D6U6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

456163:AV541 RS07280
gene id: 456163:AV541_RS07280
uniprot id: A0A0X8D837
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS09085
gene id: 456163:AV541_RS09085
uniprot id: A0A0X8D8J3
names: Similarity
messages: Belongs to the P(II) protein family.

456163:AV541 RS08625
gene id: 456163:AV541_RS08625
uniprot id: H7GF34
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

456163:AV541 RS06650
gene id: 456163:AV541_RS06650
uniprot id: A0A109QEL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

456163:AV541 RS00785
gene id: 456163:AV541_RS00785
uniprot id: H7GIW6
names: Subcellular Location Annotation
messages: Cytoplasm

456163:AV541 RS06260
gene id: 456163:AV541_RS06260
uniprot id: A0A120HT87
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

456163:AV541 RS04090
gene id: 456163:AV541_RS04090
uniprot id: A0A0X8D7A3
names: Similarity
messages: Belongs to the glutamine synthetase family.

456163:AV541 RS00820
gene id: 456163:AV541_RS00820
uniprot id: H7GIW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

456163:AV541 RS04625
gene id: 456163:AV541_RS04625
uniprot id: H7GEL7
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Periplasm

456163:AV541 RS02870
gene id: 456163:AV541_RS02870
uniprot id: A0A0X8D6G6
names: Cofactor
messages: Binds 1 FAD per subunit.

456163:AV541 RS02490
gene id: 456163:AV541_RS02490
uniprot id: A0A109QK39
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

456163:AV541 RS03330
gene id: 456163:AV541_RS03330
uniprot id: H7GHD3
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

456163:AV541 RS06110
gene id: 456163:AV541_RS06110
uniprot id: H7GDU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

456163:AV541 RS05315
gene id: 456163:AV541_RS05315
uniprot id: A0A109QEG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

456163:AV541 RS04410
gene id: 456163:AV541_RS04410
uniprot id: A0A0X8D6W0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

456163:AV541 RS06370
gene id: 456163:AV541_RS06370
uniprot id: A0A109QF86
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis.
messages: Cytoplasm

456163:AV541 RS02995
gene id: 456163:AV541_RS02995
uniprot id: A0A0X8D6I6
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

456163:AV541 RS02060
gene id: 456163:AV541_RS02060
uniprot id: A0A0X8D869
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

456163:AV541 RS05050
gene id: 456163:AV541_RS05050
uniprot id: A0A0X8D7X5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

456163:AV541 RS07355
gene id: 456163:AV541_RS07355
uniprot id: A0A0X8D7M7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

456163:AV541 RS02530
gene id: 456163:AV541_RS02530
uniprot id: H7GHS4
names: Similarity
messages: Belongs to the LOG family.

456163:AV541 RS02845
gene id: 456163:AV541_RS02845
uniprot id: A0A120HT38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

456163:AV541 RS09810
gene id: 456163:AV541_RS09810
uniprot id: H7GDZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

456163:AV541 RS03970
gene id: 456163:AV541_RS03970
uniprot id: H7GH11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

456163:AV541 RS09825
gene id: 456163:AV541_RS09825
uniprot id: A0A0X8D8R9
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

456163:AV541 RS02975
gene id: 456163:AV541_RS02975
uniprot id: A0A109QJK5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

456163:AV541 RS05435
gene id: 456163:AV541_RS05435
uniprot id: A0A120HT75
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS03805
gene id: 456163:AV541_RS03805
uniprot id: A0A0X8D8M3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

456163:AV541 RS05450
gene id: 456163:AV541_RS05450
uniprot id: A0A0X8D763
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

456163:AV541 RS07970
gene id: 456163:AV541_RS07970
uniprot id: A0A109QJX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

456163:AV541 RS05400
gene id: 456163:AV541_RS05400
uniprot id: A0A0X8D9C2
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

456163:AV541 RS06750
gene id: 456163:AV541_RS06750
uniprot id: A0A120HT96
names: Subcellular Location Annotation
messages: Nucleus

456163:AV541 RS06130
gene id: 456163:AV541_RS06130
uniprot id: A0A0X8D806
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

456163:AV541 RS06705
gene id: 456163:AV541_RS06705
uniprot id: A0A0X8D9M3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnE family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.

456163:AV541 RS03975
gene id: 456163:AV541_RS03975
uniprot id: A0A109QJM8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

456163:AV541 RS06195
gene id: 456163:AV541_RS06195
uniprot id: A0A0X8D7S5
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

456163:AV541 RS02475
gene id: 456163:AV541_RS02475
uniprot id: A0A0X8D6V6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

456163:AV541 RS07955
gene id: 456163:AV541_RS07955
uniprot id: A0A0X8DDC7
names: Similarity
messages: Belongs to the TlyA family.

456163:AV541 RS09830
gene id: 456163:AV541_RS09830
uniprot id: H7GDZ2
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

456163:AV541 RS05310
gene id: 456163:AV541_RS05310
uniprot id: A0A109QEH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

456163:AV541 RS05525
gene id: 456163:AV541_RS05525
uniprot id: A0A0X8DCR6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane
messages: Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents.

456163:AV541 RS10035
gene id: 456163:AV541_RS10035
uniprot id: A0A0X8D9Z7
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

456163:AV541 RS06340
gene id: 456163:AV541_RS06340
uniprot id: A0A109QK52
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

456163:AV541 RS00925
gene id: 456163:AV541_RS00925
uniprot id: A0A0X8D6X8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

456163:AV541 RS08910
gene id: 456163:AV541_RS08910
uniprot id: H7GIV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

456163:AV541 RS04055
gene id: 456163:AV541_RS04055
uniprot id: A0A109QED2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

456163:AV541 RS07605
gene id: 456163:AV541_RS07605
uniprot id: A0A109QJW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.
messages: Homotetramer composed of a dimer of dimers.

456163:AV541 RS00155
gene id: 456163:AV541_RS00155
uniprot id: A0A0X8D6J8
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

456163:AV541 RS00960
gene id: 456163:AV541_RS00960
uniprot id: A0A0X8D6R0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

456163:AV541 RS00235
gene id: 456163:AV541_RS00235
uniprot id: A0A0X8D6S6
names: Function
names: Similarity
messages: Belongs to the PstS family.
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.

456163:AV541 RS08725
gene id: 456163:AV541_RS08725
uniprot id: A0A109QJY6
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

456163:AV541 RS04505
gene id: 456163:AV541_RS04505
uniprot id: A0A120HT63
names: Function
names: Similarity
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.

456163:AV541 RS05270
gene id: 456163:AV541_RS05270
uniprot id: A0A0X8D903
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS06135
gene id: 456163:AV541_RS06135
uniprot id: A0A0X8D988
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

456163:AV541 RS04760
gene id: 456163:AV541_RS04760
uniprot id: A0A0X8D975
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

456163:AV541 RS01730
gene id: 456163:AV541_RS01730
uniprot id: H7GID8
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.

456163:AV541 RS05480
gene id: 456163:AV541_RS05480
uniprot id: A0A0X8DA34
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

456163:AV541 RS04795
gene id: 456163:AV541_RS04795
uniprot id: A0A109QIG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

456163:AV541 RS05830
gene id: 456163:AV541_RS05830
uniprot id: A0A0X8D792
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LamB/PxpA family.
messages: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Forms a complex composed of PxpA, PxpB and PxpC.

456163:AV541 RS08440
gene id: 456163:AV541_RS08440
uniprot id: A0A0X8D9K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

456163:AV541 RS00390
gene id: 456163:AV541_RS00390
uniprot id: A0A0X8D7T9
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

456163:AV541 RS10570
gene id: 456163:AV541_RS10570
uniprot id: H7GER9
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

456163:AV541 RS03280
gene id: 456163:AV541_RS03280
uniprot id: A0A0X8D7L5
names: Similarity
messages: Belongs to the peptidase S49 family.

456163:AV541 RS02415
gene id: 456163:AV541_RS02415
uniprot id: H7GI60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

456163:AV541 RS03570
gene id: 456163:AV541_RS03570
uniprot id: A0A0X8D753
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

456163:AV541 RS09295
gene id: 456163:AV541_RS09295
uniprot id: A0A120HTC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 15 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

456163:AV541 RS05580
gene id: 456163:AV541_RS05580
uniprot id: H7GGD4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

456163:AV541 RS01390
gene id: 456163:AV541_RS01390
uniprot id: H7GIK3
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

456163:AV541 RS01365
gene id: 456163:AV541_RS01365
uniprot id: A0A0X8D6J1
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

456163:AV541 RS00505
gene id: 456163:AV541_RS00505
uniprot id: A0A109QE25
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Cell membrane
messages: Membrane
messages: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

456163:AV541 RS05280
gene id: 456163:AV541_RS05280
uniprot id: A0A0X8D7U3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

456163:AV541 RS10730
gene id: 456163:AV541_RS10730
uniprot id: A0A109QK50
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

456163:AV541 RS02385
gene id: 456163:AV541_RS02385
uniprot id: H7GHU0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

456163:AV541 RS04110
gene id: 456163:AV541_RS04110
uniprot id: A0A0X8D8R1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class II aldolase/RraA-like family.
messages: Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
messages: Homotrimer.

456163:AV541 RS05535
gene id: 456163:AV541_RS05535
uniprot id: A0A109QJT6
names: Similarity
messages: Belongs to the GreA/GreB family.

456163:AV541 RS05425
gene id: 456163:AV541_RS05425
uniprot id: A0A120HT74
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

456163:AV541 RS02960
gene id: 456163:AV541_RS02960
uniprot id: H7GHJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

456163:AV541 RS06115
gene id: 456163:AV541_RS06115
uniprot id: A0A0X8D8B1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

456163:AV541 RS00270
gene id: 456163:AV541_RS00270
uniprot id: H7GDE0
names: Similarity
messages: Belongs to the peptidase C40 family.

456163:AV541 RS03610
gene id: 456163:AV541_RS03610
uniprot id: A0A0X8D7D7
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

456163:AV541 RS05345
gene id: 456163:AV541_RS05345
uniprot id: A0A0X8D750
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

456163:AV541 RS08935
gene id: 456163:AV541_RS08935
uniprot id: A0A120HTD2
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

456163:AV541 RS03370
gene id: 456163:AV541_RS03370
uniprot id: A0A0X8D734
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS04805
gene id: 456163:AV541_RS04805
uniprot id: H7GEI3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

456163:AV541 RS04120
gene id: 456163:AV541_RS04120
uniprot id: A0A0X8D7I6
names: Similarity
messages: Belongs to the peptidase S1C family.

456163:AV541 RS00720
gene id: 456163:AV541_RS00720
uniprot id: A0A0X8D6Z9
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

456163:AV541 RS06590
gene id: 456163:AV541_RS06590
uniprot id: A0A0X8D7X7
names: Similarity
messages: Belongs to the Skp family.

456163:AV541 RS07305
gene id: 456163:AV541_RS07305
uniprot id: A0A0X8D9R4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

456163:AV541 RS07195
gene id: 456163:AV541_RS07195
uniprot id: A0A0X8D9Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

456163:AV541 RS02045
gene id: 456163:AV541_RS02045
uniprot id: A0A0X8D772
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

456163:AV541 RS00130
gene id: 456163:AV541_RS00130
uniprot id: H7GDG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

456163:AV541 RS00575
gene id: 456163:AV541_RS00575
uniprot id: A0A0X8D6C8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

456163:AV541 RS00585
gene id: 456163:AV541_RS00585
uniprot id: H7GJ05
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

456163:AV541 RS08420
gene id: 456163:AV541_RS08420
uniprot id: A0A0X8D8D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

456163:AV541 RS04080
gene id: 456163:AV541_RS04080
uniprot id: A0A0X8D6T5
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS09690
gene id: 456163:AV541_RS09690
uniprot id: A0A109QK27
names: Similarity
messages: Belongs to the DprA/Smf family.

456163:AV541 RS04340
gene id: 456163:AV541_RS04340
uniprot id: H7GGU9
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

456163:AV541 RS00705
gene id: 456163:AV541_RS00705
uniprot id: H7GIY1
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

456163:AV541 RS06400
gene id: 456163:AV541_RS06400
uniprot id: A0A0X8D888
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

456163:AV541 RS02165
gene id: 456163:AV541_RS02165
uniprot id: H7GHY0
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

456163:AV541 RS07745
gene id: 456163:AV541_RS07745
uniprot id: A0A0X8D8K8
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS04570
gene id: 456163:AV541_RS04570
uniprot id: A0A0X8D957
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

456163:AV541 RS09720
gene id: 456163:AV541_RS09720
uniprot id: A0A0X8D8Q6
names: Function
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA.

456163:AV541 RS09185
gene id: 456163:AV541_RS09185
uniprot id: A0A109QET3
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

456163:AV541 RS00060
gene id: 456163:AV541_RS00060
uniprot id: A0A0X8D7Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

456163:AV541 RS03165
gene id: 456163:AV541_RS03165
uniprot id: A0A0X8D8V0
names: Similarity
messages: Belongs to the SAICAR synthetase family.

456163:AV541 RS02435
gene id: 456163:AV541_RS02435
uniprot id: H7GI56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

456163:AV541 RS03770
gene id: 456163:AV541_RS03770
uniprot id: A0A109QFW6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS04010
gene id: 456163:AV541_RS04010
uniprot id: A0A0X8D8P4
names: Similarity
messages: Belongs to the PGI/PMI family.

456163:AV541 RS07000
gene id: 456163:AV541_RS07000
uniprot id: A0A0X8DD59
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

456163:AV541 RS08920
gene id: 456163:AV541_RS08920
uniprot id: A0A0X8DDF0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase S45 family.
messages: Binds 1 Ca(2+) ion per dimer.

456163:AV541 RS07175
gene id: 456163:AV541_RS07175
uniprot id: A0A109QK54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

456163:AV541 RS08470
gene id: 456163:AV541_RS08470
uniprot id: A0A109QK80
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL34 family.
messages: Part of the 50S ribosomal subunit.

456163:AV541 RS07570
gene id: 456163:AV541_RS07570
uniprot id: A0A0X8DDB1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

456163:AV541 RS04335
gene id: 456163:AV541_RS04335
uniprot id: H7GGV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane

456163:AV541 RS01640
gene id: 456163:AV541_RS01640
uniprot id: A0A109QIA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

456163:AV541 RS03555
gene id: 456163:AV541_RS03555
uniprot id: A0A0X8D6N6
names: Similarity
messages: Belongs to the AlaDH/PNT family.

456163:AV541 RS04650
gene id: 456163:AV541_RS04650
uniprot id: A0A0X8D7E7
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Cell outer membrane
messages: Membrane
messages: Periplasm

456163:AV541 RS09255
gene id: 456163:AV541_RS09255
uniprot id: A0A0X8D9W9
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

456163:AV541 RS07065
gene id: 456163:AV541_RS07065
uniprot id: A0A0X8D9C4
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

456163:AV541 RS08525
gene id: 456163:AV541_RS08525
uniprot id: H7GF54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsbB family. BdbC subfamily.
messages: Membrane

456163:AV541 RS03745
gene id: 456163:AV541_RS03745
uniprot id: H7GH51
names: Similarity
messages: Belongs to the bacterial ribosomal protein bTHX family.

456163:AV541 RS00215
gene id: 456163:AV541_RS00215
uniprot id: A0A0X8D5U7
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

456163:AV541 RS01760
gene id: 456163:AV541_RS01760
uniprot id: H7GID4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

456163:AV541 RS06545
gene id: 456163:AV541_RS06545
uniprot id: A0A109QJW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

456163:AV541 RS02710
gene id: 456163:AV541_RS02710
uniprot id: A0A0X8D8G5
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

456163:AV541 RS07310
gene id: 456163:AV541_RS07310
uniprot id: A0A0X8D8A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

456163:AV541 RS03160
gene id: 456163:AV541_RS03160
uniprot id: A0A0X8D8H0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

456163:AV541 RS06540
gene id: 456163:AV541_RS06540
uniprot id: A0A120HT89
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

456163:AV541 RS07485
gene id: 456163:AV541_RS07485
uniprot id: H7GFN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

456163:AV541 RS03300
gene id: 456163:AV541_RS03300
uniprot id: A0A0X8D7A6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

456163:AV541 RS02180
gene id: 456163:AV541_RS02180
uniprot id: A0A109QE68
names: Similarity
messages: Belongs to the ChdC family. Type 1 subfamily.

456163:AV541 RS08375
gene id: 456163:AV541_RS08375
uniprot id: H7GF80
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 2 family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS02485
gene id: 456163:AV541_RS02485
uniprot id: A0A0X8D7F3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

456163:AV541 RS01835
gene id: 456163:AV541_RS01835
uniprot id: H7GI42
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

456163:AV541 RS06910
gene id: 456163:AV541_RS06910
uniprot id: H7GFT7
names: Similarity
messages: Belongs to the SufE family.

456163:AV541 RS01240
gene id: 456163:AV541_RS01240
uniprot id: A0A0X8D628
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

456163:AV541 RS01065
gene id: 456163:AV541_RS01065
uniprot id: A0A0X8D6R9
names: Similarity
messages: Belongs to the SCO1/2 family.

456163:AV541 RS05770
gene id: 456163:AV541_RS05770
uniprot id: A0A109QIH9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS08895
gene id: 456163:AV541_RS08895
uniprot id: H7GIU8
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.

456163:AV541 RS04330
gene id: 456163:AV541_RS04330
uniprot id: A0A0X8D7T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

456163:AV541 RS06885
gene id: 456163:AV541_RS06885
uniprot id: A0A120HT97
names: Similarity
messages: Belongs to the peptidase S8 family.

456163:AV541 RS00970
gene id: 456163:AV541_RS00970
uniprot id: A0A109QI87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

456163:AV541 RS07120
gene id: 456163:AV541_RS07120
uniprot id: A0A120HTA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

456163:AV541 RS04525
gene id: 456163:AV541_RS04525
uniprot id: A0A0X8D6X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

456163:AV541 RS09250
gene id: 456163:AV541_RS09250
uniprot id: A0A0X8D8R4
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

456163:AV541 RS03505
gene id: 456163:AV541_RS03505
uniprot id: A0A0X8D7C7
names: Similarity
messages: Belongs to the cytochrome b560 family.

456163:AV541 RS05490
gene id: 456163:AV541_RS05490
uniprot id: A0A0X8D921
names: Similarity
messages: Belongs to the IMPACT family.

456163:AV541 RS07565
gene id: 456163:AV541_RS07565
uniprot id: H7GFM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

456163:AV541 RS00755
gene id: 456163:AV541_RS00755
uniprot id: A0A0X8DBZ2
names: Similarity
messages: Belongs to the phosphohexose mutase family.

456163:AV541 RS01745
gene id: 456163:AV541_RS01745
uniprot id: A0A0X9ZPV2
names: Similarity
messages: Belongs to the FUN14 family.

456163:AV541 RS01310
gene id: 456163:AV541_RS01310
uniprot id: A0A109QI95
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

456163:AV541 RS02410
gene id: 456163:AV541_RS02410
uniprot id: A0A0X8D8A4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

456163:AV541 RS07940
gene id: 456163:AV541_RS07940
uniprot id: A0A0X8D8F2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

456163:AV541 RS02535
gene id: 456163:AV541_RS02535
uniprot id: A0A0X8DC87
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

456163:AV541 RS08170
gene id: 456163:AV541_RS08170
uniprot id: A0A0X8D9J1
names: Similarity
messages: Belongs to the malate synthase family.

456163:AV541 RS10750
gene id: 456163:AV541_RS10750
uniprot id: A0A0X8D8R0
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS00760
gene id: 456163:AV541_RS00760
uniprot id: A0A120HT03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

456163:AV541 RS04905
gene id: 456163:AV541_RS04905
uniprot id: A0A120HT64
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

456163:AV541 RS02660
gene id: 456163:AV541_RS02660
uniprot id: A0A0X8D6F8
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS07205
gene id: 456163:AV541_RS07205
uniprot id: A0A0X8D9F7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

456163:AV541 RS08755
gene id: 456163:AV541_RS08755
uniprot id: A0A0X8D8Y1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS06815
gene id: 456163:AV541_RS06815
uniprot id: H7GFV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

456163:AV541 RS02295
gene id: 456163:AV541_RS02295
uniprot id: H7GHV6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

456163:AV541 RS01615
gene id: 456163:AV541_RS01615
uniprot id: A0A0X8D770
names: Similarity
messages: Belongs to the CinA family.

456163:AV541 RS05240
gene id: 456163:AV541_RS05240
uniprot id: A0A0X8D732
names: Similarity
messages: Belongs to the FemABX family.

456163:AV541 RS06850
gene id: 456163:AV541_RS06850
uniprot id: A0A0X8D9N0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

456163:AV541 RS01320
gene id: 456163:AV541_RS01320
uniprot id: A0A120HT09
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

456163:AV541 RS06875
gene id: 456163:AV541_RS06875
uniprot id: A0A0X8DD49
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

456163:AV541 RS02350
gene id: 456163:AV541_RS02350
uniprot id: H7GHU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

456163:AV541 RS08065
gene id: 456163:AV541_RS08065
uniprot id: A0A109QK76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

456163:AV541 RS07165
gene id: 456163:AV541_RS07165
uniprot id: A0A0X8D8F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

456163:AV541 RS09965
gene id: 456163:AV541_RS09965
uniprot id: A0A0X8DDM0
names: Subcellular Location Annotation
messages: Cytoplasm

456163:AV541 RS06945
gene id: 456163:AV541_RS06945
uniprot id: H7GFT2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

456163:AV541 RS04885
gene id: 456163:AV541_RS04885
uniprot id: A0A0X8D904
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
messages: Cytoplasm

456163:AV541 RS07395
gene id: 456163:AV541_RS07395
uniprot id: A0A0X8D9E1
names: Similarity
messages: Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.

456163:AV541 RS01030
gene id: 456163:AV541_RS01030
uniprot id: H7GIQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

456163:AV541 RS03275
gene id: 456163:AV541_RS03275
uniprot id: H7GHE1
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS08635
gene id: 456163:AV541_RS08635
uniprot id: A0A0X8D7Y5
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

456163:AV541 RS01245
gene id: 456163:AV541_RS01245
uniprot id: H7GIM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

456163:AV541 RS06170
gene id: 456163:AV541_RS06170
uniprot id: A0A120HT86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

456163:AV541 RS06830
gene id: 456163:AV541_RS06830
uniprot id: H7GFV3
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

456163:AV541 RS08410
gene id: 456163:AV541_RS08410
uniprot id: A0A0X8D7V3
names: Similarity
messages: Belongs to the Nudix hydrolase family.

456163:AV541 RS06420
gene id: 456163:AV541_RS06420
uniprot id: A0A0X8D9J4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS02810
gene id: 456163:AV541_RS02810
uniprot id: A0A0X8D8H6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

456163:AV541 RS08745
gene id: 456163:AV541_RS08745
uniprot id: A0A0X8D8T8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

456163:AV541 RS01550
gene id: 456163:AV541_RS01550
uniprot id: H7GIH2
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS10170
gene id: 456163:AV541_RS10170
uniprot id: A0A0X8D989
names: Similarity
messages: Belongs to the AlaDH/PNT family.

456163:AV541 RS10655
gene id: 456163:AV541_RS10655
uniprot id: A0A0X8D9D2
names: Cofactor
names: Similarity
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.

456163:AV541 RS00430
gene id: 456163:AV541_RS00430
uniprot id: H7GGL7
names: Similarity
messages: Belongs to the universal stress protein A family.

456163:AV541 RS04910
gene id: 456163:AV541_RS04910
uniprot id: H7GGS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

456163:AV541 RS01120
gene id: 456163:AV541_RS01120
uniprot id: A0A0X8D610
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS00370
gene id: 456163:AV541_RS00370
uniprot id: A0A0X8D844
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

456163:AV541 RS07255
gene id: 456163:AV541_RS07255
uniprot id: A0A0X8D7L7
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS08315
gene id: 456163:AV541_RS08315
uniprot id: A0A0X8D9J9
names: Function
names: Similarity
messages: Belongs to the trehalose phosphatase family.
messages: Removes the phosphate from trehalose 6-phosphate to produce free trehalose.

456163:AV541 RS01575
gene id: 456163:AV541_RS01575
uniprot id: A0A109QEU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

456163:AV541 RS01655
gene id: 456163:AV541_RS01655
uniprot id: A0A120HT15
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

456163:AV541 RS10200
gene id: 456163:AV541_RS10200
uniprot id: A0A0X8DA55
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

456163:AV541 RS09390
gene id: 456163:AV541_RS09390
uniprot id: H7GE73
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

456163:AV541 RS06665
gene id: 456163:AV541_RS06665
uniprot id: A0A109QG55
names: Similarity
messages: Belongs to the GARS family.

456163:AV541 RS04670
gene id: 456163:AV541_RS04670
uniprot id: A0A0X8D968
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS03485
gene id: 456163:AV541_RS03485
uniprot id: A0A0X8D8J8
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS05105
gene id: 456163:AV541_RS05105
uniprot id: A0A120HT69
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

456163:AV541 RS10195
gene id: 456163:AV541_RS10195
uniprot id: A0A0X8D910
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

456163:AV541 RS09940
gene id: 456163:AV541_RS09940
uniprot id: A0A0X8DAE1
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

456163:AV541 RS02020
gene id: 456163:AV541_RS02020
uniprot id: A0A120HT20
names: Similarity
messages: Belongs to the thioredoxin family.

456163:AV541 RS05060
gene id: 456163:AV541_RS05060
uniprot id: H7GGP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

456163:AV541 RS01635
gene id: 456163:AV541_RS01635
uniprot id: A0A0X8D855
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS09025
gene id: 456163:AV541_RS09025
uniprot id: A0A0X8D8P2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

456163:AV541 RS06730
gene id: 456163:AV541_RS06730
uniprot id: A0A0X8DD35
names: Similarity
messages: Belongs to the prephenate/arogenate dehydrogenase family.

456163:AV541 RS03465
gene id: 456163:AV541_RS03465
uniprot id: H7GHA5
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

456163:AV541 RS03795
gene id: 456163:AV541_RS03795
uniprot id: A0A0X8D7N2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS01685
gene id: 456163:AV541_RS01685
uniprot id: A0A120HT14
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

456163:AV541 RS09225
gene id: 456163:AV541_RS09225
uniprot id: A0A0X8D8X7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

456163:AV541 RS00175
gene id: 456163:AV541_RS00175
uniprot id: A0A120HT26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

456163:AV541 RS01560
gene id: 456163:AV541_RS01560
uniprot id: A0A0X8DC38
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

456163:AV541 RS06255
gene id: 456163:AV541_RS06255
uniprot id: A0A0X8DCX8
names: Similarity
messages: Belongs to the universal stress protein A family.

456163:AV541 RS09725
gene id: 456163:AV541_RS09725
uniprot id: A0A0X8D919
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

456163:AV541 RS00500
gene id: 456163:AV541_RS00500
uniprot id: A0A109QE27
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

456163:AV541 RS06430
gene id: 456163:AV541_RS06430
uniprot id: A0A0X8D9B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

456163:AV541 RS06155
gene id: 456163:AV541_RS06155
uniprot id: A0A120HT84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

456163:AV541 RS09780
gene id: 456163:AV541_RS09780
uniprot id: A0A109QK96
names: Similarity
messages: Belongs to the RutC family.

456163:AV541 RS09455
gene id: 456163:AV541_RS09455
uniprot id: A0A109QK94
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS09170
gene id: 456163:AV541_RS09170
uniprot id: A0A0X8DDF4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

456163:AV541 RS05980
gene id: 456163:AV541_RS05980
uniprot id: H7GG74
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

456163:AV541 RS01880
gene id: 456163:AV541_RS01880
uniprot id: A0A109QE62
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

456163:AV541 RS03695
gene id: 456163:AV541_RS03695
uniprot id: A0A0X8D8L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane

456163:AV541 RS05395
gene id: 456163:AV541_RS05395
uniprot id: H7GGG6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

456163:AV541 RS00765
gene id: 456163:AV541_RS00765
uniprot id: A0A109QJG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

456163:AV541 RS07620
gene id: 456163:AV541_RS07620
uniprot id: A0A0X8D868
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

456163:AV541 RS03800
gene id: 456163:AV541_RS03800
uniprot id: A0A0X8D7R3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.

456163:AV541 RS00815
gene id: 456163:AV541_RS00815
uniprot id: A0A0X8D709
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

456163:AV541 RS09695
gene id: 456163:AV541_RS09695
uniprot id: H7GE16
names: Similarity
messages: Belongs to the manganese catalase family.

456163:AV541 RS03960
gene id: 456163:AV541_RS03960
uniprot id: H7GH13
names: Similarity
messages: Belongs to the CutA family.

456163:AV541 RS04255
gene id: 456163:AV541_RS04255
uniprot id: H7GGW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

456163:AV541 RS04225
gene id: 456163:AV541_RS04225
uniprot id: A0A0X8D8V4
names: Similarity
messages: Belongs to the BMP lipoprotein family.

456163:AV541 RS00295
gene id: 456163:AV541_RS00295
uniprot id: A0A120HSZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

456163:AV541 RS07960
gene id: 456163:AV541_RS07960
uniprot id: A0A120HTB1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS09805
gene id: 456163:AV541_RS09805
uniprot id: A0A109QFI9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

456163:AV541 RS08915
gene id: 456163:AV541_RS08915
uniprot id: A0A109QIS6
names: Similarity
messages: Belongs to the peptidase S16 family.

456163:AV541 RS02825
gene id: 456163:AV541_RS02825
uniprot id: A0A109QIC9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

456163:AV541 RS05575
gene id: 456163:AV541_RS05575
uniprot id: A0A0X8D819
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

456163:AV541 RS00165
gene id: 456163:AV541_RS00165
uniprot id: H7GDF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

456163:AV541 RS08620
gene id: 456163:AV541_RS08620
uniprot id: A0A120HTC2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

456163:AV541 RS02945
gene id: 456163:AV541_RS02945
uniprot id: A0A0X8D8I8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

456163:AV541 RS03420
gene id: 456163:AV541_RS03420
uniprot id: A0A0X8DCB4
names: Similarity
messages: Belongs to the glutamate synthase family.

456163:AV541 RS01620
gene id: 456163:AV541_RS01620
uniprot id: H7GIF9
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

456163:AV541 RS04865
gene id: 456163:AV541_RS04865
uniprot id: A0A0X8D809
names: Similarity
messages: Belongs to the fructosamine kinase family.

456163:AV541 RS00160
gene id: 456163:AV541_RS00160
uniprot id: H7GDF8
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

456163:AV541 RS01755
gene id: 456163:AV541_RS01755
uniprot id: A0A109QJJ1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS06320
gene id: 456163:AV541_RS06320
uniprot id: A0A0X8D824
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS02445
gene id: 456163:AV541_RS02445
uniprot id: H7GI54
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

456163:AV541 RS00715
gene id: 456163:AV541_RS00715
uniprot id: A0A0X8D6V8
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

456163:AV541 RS03700
gene id: 456163:AV541_RS03700
uniprot id: A0A0X8D8Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmE/CycJ family.
messages: Cell membrane
messages: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.

456163:AV541 RS05990
gene id: 456163:AV541_RS05990
uniprot id: H7GG72
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

456163:AV541 RS01910
gene id: 456163:AV541_RS01910
uniprot id: H7GI27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

456163:AV541 RS10130
gene id: 456163:AV541_RS10130
uniprot id: A0A109QFJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

456163:AV541 RS01330
gene id: 456163:AV541_RS01330
uniprot id: A0A120HT10
names: Similarity
messages: Belongs to the peptidase M29 family.

456163:AV541 RS07140
gene id: 456163:AV541_RS07140
uniprot id: A0A120HTA1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS02235
gene id: 456163:AV541_RS02235
uniprot id: A0A0X8D6A4
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS09090
gene id: 456163:AV541_RS09090
uniprot id: A0A0X8D8W6
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

456163:AV541 RS07850
gene id: 456163:AV541_RS07850
uniprot id: H7GFH6
names: Similarity
messages: Belongs to the acylphosphatase family.

456163:AV541 RS02090
gene id: 456163:AV541_RS02090
uniprot id: A0A120HT22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

456163:AV541 RS10025
gene id: 456163:AV541_RS10025
uniprot id: A0A0X8D950
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

456163:AV541 RS10055
gene id: 456163:AV541_RS10055
uniprot id: H7GDV3
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS05275
gene id: 456163:AV541_RS05275
uniprot id: A0A0X8D9B6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.

456163:AV541 RS07905
gene id: 456163:AV541_RS07905
uniprot id: A0A0X8D8L7
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily.
messages: Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2).

456163:AV541 RS08185
gene id: 456163:AV541_RS08185
uniprot id: A0A0X8D9Y3
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

456163:AV541 RS03995
gene id: 456163:AV541_RS03995
uniprot id: H7GH06
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

456163:AV541 RS04955
gene id: 456163:AV541_RS04955
uniprot id: A0A0X8D817
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS04480
gene id: 456163:AV541_RS04480
uniprot id: A0A0X8D8X1
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

456163:AV541 RS07855
gene id: 456163:AV541_RS07855
uniprot id: A0A0X8DDC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

456163:AV541 RS03810
gene id: 456163:AV541_RS03810
uniprot id: A0A0X8D907
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial secretin family.
messages: Cell outer membrane

456163:AV541 RS05135
gene id: 456163:AV541_RS05135
uniprot id: A0A0X8D7J3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

456163:AV541 RS03895
gene id: 456163:AV541_RS03895
uniprot id: A0A0X8D7S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

456163:AV541 RS02030
gene id: 456163:AV541_RS02030
uniprot id: A0A0X8D686
names: Similarity
messages: Belongs to the archease family.

456163:AV541 RS02345
gene id: 456163:AV541_RS02345
uniprot id: A0A0X8D727
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

456163:AV541 RS07920
gene id: 456163:AV541_RS07920
uniprot id: H7GFG2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

456163:AV541 RS10950
gene id: 456163:AV541_RS10950
uniprot id: A0A109QJ03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: Cell membrane
messages: Membrane

456163:AV541 RS04170
gene id: 456163:AV541_RS04170
uniprot id: A0A0X8D925
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

456163:AV541 RS01820
gene id: 456163:AV541_RS01820
uniprot id: H7GI44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

456163:AV541 RS10135
gene id: 456163:AV541_RS10135
uniprot id: H7GDJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

456163:AV541 RS07215
gene id: 456163:AV541_RS07215
uniprot id: A0A0X8DD79
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

456163:AV541 RS00300
gene id: 456163:AV541_RS00300
uniprot id: A0A120HSZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

456163:AV541 RS08650
gene id: 456163:AV541_RS08650
uniprot id: A0A0X8D8X3
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

456163:AV541 RS09270
gene id: 456163:AV541_RS09270
uniprot id: H7GE92
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 15 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

456163:AV541 RS07925
gene id: 456163:AV541_RS07925
uniprot id: H7GFG1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

456163:AV541 RS03390
gene id: 456163:AV541_RS03390
uniprot id: A0A0X8D8W9
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS05635
gene id: 456163:AV541_RS05635
uniprot id: A0A109QEI2
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS08605
gene id: 456163:AV541_RS08605
uniprot id: H7GF38
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

456163:AV541 RS08310
gene id: 456163:AV541_RS08310
uniprot id: A0A0X8D8U3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyltransferase 20 family.
messages: Homotetramer.
messages: Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-alpha-D-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor.

456163:AV541 RS06920
gene id: 456163:AV541_RS06920
uniprot id: A0A109QJV0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

456163:AV541 RS03530
gene id: 456163:AV541_RS03530
uniprot id: A0A120HT44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Cytoplasm
messages: Homodimer.

456163:AV541 RS07980
gene id: 456163:AV541_RS07980
uniprot id: A0A0X8D7U2
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

456163:AV541 RS04875
gene id: 456163:AV541_RS04875
uniprot id: A0A0X8D983
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pseudouridine-5'-phosphate glycosidase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
messages: Homotrimer.

456163:AV541 RS06125
gene id: 456163:AV541_RS06125
uniprot id: A0A0X8D9H0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS02330
gene id: 456163:AV541_RS02330
uniprot id: A0A0X8D7D6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

456163:AV541 RS09735
gene id: 456163:AV541_RS09735
uniprot id: H7GE09
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS02605
gene id: 456163:AV541_RS02605
uniprot id: A0A0X8D8C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

456163:AV541 RS07710
gene id: 456163:AV541_RS07710
uniprot id: H7GFJ8
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS01670
gene id: 456163:AV541_RS01670
uniprot id: A0A120HT17
names: Similarity
messages: Belongs to the peptidase S33 family.

456163:AV541 RS05155
gene id: 456163:AV541_RS05155
uniprot id: H7GGK6
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

456163:AV541 RS02550
gene id: 456163:AV541_RS02550
uniprot id: A0A120HT33
names: Caution
names: Function
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
messages: Catalyzes the biosynthesis of agmatine from arginine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS05860
gene id: 456163:AV541_RS05860
uniprot id: A0A0X8D836
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

456163:AV541 RS02185
gene id: 456163:AV541_RS02185
uniprot id: A0A109QE72
names: Similarity
messages: Belongs to the UPF0047 family.

456163:AV541 RS05430
gene id: 456163:AV541_RS05430
uniprot id: A0A120HT78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

456163:AV541 RS00230
gene id: 456163:AV541_RS00230
uniprot id: A0A0X8D697
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS05040
gene id: 456163:AV541_RS05040
uniprot id: A0A0X8D713
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

456163:AV541 RS01465
gene id: 456163:AV541_RS01465
uniprot id: A0A0X8D996
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

456163:AV541 RS06555
gene id: 456163:AV541_RS06555
uniprot id: A0A109QJU3
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

456163:AV541 RS10470
gene id: 456163:AV541_RS10470
uniprot id: A0A0X8DAF1
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

456163:AV541 RS07550
gene id: 456163:AV541_RS07550
uniprot id: A0A0X8D9I8
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

456163:AV541 RS01700
gene id: 456163:AV541_RS01700
uniprot id: A0A0X8D6M5
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

456163:AV541 RS04345
gene id: 456163:AV541_RS04345
uniprot id: A0A0X8D945
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

456163:AV541 RS07110
gene id: 456163:AV541_RS07110
uniprot id: A0A0X8DD69
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

456163:AV541 RS09020
gene id: 456163:AV541_RS09020
uniprot id: H7GED4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

456163:AV541 RS02590
gene id: 456163:AV541_RS02590
uniprot id: A0A0X8D7C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

456163:AV541 RS00410
gene id: 456163:AV541_RS00410
uniprot id: A0A109QJG2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

456163:AV541 RS05285
gene id: 456163:AV541_RS05285
uniprot id: A0A0X8D940
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

456163:AV541 RS02050
gene id: 456163:AV541_RS02050
uniprot id: H7GI01
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS02950
gene id: 456163:AV541_RS02950
uniprot id: H7GHJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

456163:AV541 RS00405
gene id: 456163:AV541_RS00405
uniprot id: A0A120HSZ8
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

456163:AV541 RS07115
gene id: 456163:AV541_RS07115
uniprot id: A0A120HTA0
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

456163:AV541 RS02565
gene id: 456163:AV541_RS02565
uniprot id: H7GHR7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS09960
gene id: 456163:AV541_RS09960
uniprot id: A0A109QK41
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

456163:AV541 RS02355
gene id: 456163:AV541_RS02355
uniprot id: A0A109QJK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

456163:AV541 RS03205
gene id: 456163:AV541_RS03205
uniprot id: A0A0X8DCA8
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

456163:AV541 RS10165
gene id: 456163:AV541_RS10165
uniprot id: A0A0X8D949
names: Similarity
messages: Belongs to the asp23 family.

456163:AV541 RS06190
gene id: 456163:AV541_RS06190
uniprot id: A0A0X8D7A9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

456163:AV541 RS00910
gene id: 456163:AV541_RS00910
uniprot id: A0A0X8D5Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

456163:AV541 RS01970
gene id: 456163:AV541_RS01970
uniprot id: A0A0X8D8I5
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

456163:AV541 RS08555
gene id: 456163:AV541_RS08555
uniprot id: A0A0X8DA12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

456163:AV541 RS04675
gene id: 456163:AV541_RS04675
uniprot id: A0A0X8D7N6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homodimer.

456163:AV541 RS10005
gene id: 456163:AV541_RS10005
uniprot id: H7GDW1
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

456163:AV541 RS04995
gene id: 456163:AV541_RS04995
uniprot id: A0A0X8DCK9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0).

456163:AV541 RS08260
gene id: 456163:AV541_RS08260
uniprot id: H7GFA2
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

456163:AV541 RS04620
gene id: 456163:AV541_RS04620
uniprot id: H7GEL8
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS02425
gene id: 456163:AV541_RS02425
uniprot id: H7GI58
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

456163:AV541 RS08200
gene id: 456163:AV541_RS08200
uniprot id: A0A0X8D9M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

456163:AV541 RS05145
gene id: 456163:AV541_RS05145
uniprot id: A0A0X8D7Y2
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

456163:AV541 RS04980
gene id: 456163:AV541_RS04980
uniprot id: A0A0X8D7R9
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

456163:AV541 RS03740
gene id: 456163:AV541_RS03740
uniprot id: H7GH52
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

456163:AV541 RS09275
gene id: 456163:AV541_RS09275
uniprot id: A0A120HTC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

456163:AV541 RS01355
gene id: 456163:AV541_RS01355
uniprot id: A0A0X8D629
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

456163:AV541 RS05325
gene id: 456163:AV541_RS05325
uniprot id: A0A109QG14
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS09060
gene id: 456163:AV541_RS09060
uniprot id: A0A109QK12
names: Similarity
messages: Belongs to the histone deacetylase family.

456163:AV541 RS01130
gene id: 456163:AV541_RS01130
uniprot id: A0A0X8D6Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

456163:AV541 RS02400
gene id: 456163:AV541_RS02400
uniprot id: A0A0X8D7B0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

456163:AV541 RS06270
gene id: 456163:AV541_RS06270
uniprot id: A0A109QJT1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

456163:AV541 RS02770
gene id: 456163:AV541_RS02770
uniprot id: H7GHM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

456163:AV541 RS01135
gene id: 456163:AV541_RS01135
uniprot id: H7GIP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

456163:AV541 RS08425
gene id: 456163:AV541_RS08425
uniprot id: A0A0X8D8Q5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

456163:AV541 RS03460
gene id: 456163:AV541_RS03460
uniprot id: A0A0X8D6L5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

456163:AV541 RS04915
gene id: 456163:AV541_RS04915
uniprot id: A0A109QJP7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

456163:AV541 RS00135
gene id: 456163:AV541_RS00135
uniprot id: A0A0X8D7P4
names: Caution
names: Function
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

456163:AV541 RS00245
gene id: 456163:AV541_RS00245
uniprot id: A0A0X8D7Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

456163:AV541 RS09230
gene id: 456163:AV541_RS09230
uniprot id: H7GEA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 15 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

456163:AV541 RS09280
gene id: 456163:AV541_RS09280
uniprot id: A0A120HTD6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: NDH-1 is composed of 15 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

456163:AV541 RS04530
gene id: 456163:AV541_RS04530
uniprot id: H7GEN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

456163:AV541 RS00740
gene id: 456163:AV541_RS00740
uniprot id: A0A0X8D7X8
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS06475
gene id: 456163:AV541_RS06475
uniprot id: A0A0X8D7F0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

456163:AV541 RS06905
gene id: 456163:AV541_RS06905
uniprot id: A0A109QJW5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

456163:AV541 RS05735
gene id: 456163:AV541_RS05735
uniprot id: A0A0X8D7X9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

456163:AV541 RS07615
gene id: 456163:AV541_RS07615
uniprot id: A0A0X8D7N7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

456163:AV541 RS02375
gene id: 456163:AV541_RS02375
uniprot id: A0A109QJJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

456163:AV541 RS07160
gene id: 456163:AV541_RS07160
uniprot id: A0A0X8D827
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

456163:AV541 RS08365
gene id: 456163:AV541_RS08365
uniprot id: A0A109QK03
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

456163:AV541 RS05160
gene id: 456163:AV541_RS05160
uniprot id: A0A0X8D9A7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

456163:AV541 RS09945
gene id: 456163:AV541_RS09945
uniprot id: A0A0X8D8Z0
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

456163:AV541 RS09240
gene id: 456163:AV541_RS09240
uniprot id: H7GE98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 15 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

456163:AV541 RS00990
gene id: 456163:AV541_RS00990
uniprot id: A0A120HT04
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

456163:AV541 RS01085
gene id: 456163:AV541_RS01085
uniprot id: A0A0X8DC13
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

456163:AV541 RS01580
gene id: 456163:AV541_RS01580
uniprot id: A0A109QFP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

456163:AV541 RS00735
gene id: 456163:AV541_RS00735
uniprot id: A0A0X8D6P0
names: Similarity
messages: Belongs to the universal stress protein A family.

456163:AV541 RS04430
gene id: 456163:AV541_RS04430
uniprot id: A0A0X8D7X6
names: Similarity
messages: Belongs to the UPF0145 family.

456163:AV541 RS07610
gene id: 456163:AV541_RS07610
uniprot id: A0A0X8D7P7
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.

456163:AV541 RS08580
gene id: 456163:AV541_RS08580
uniprot id: A0A109QIR4
names: Similarity
messages: Belongs to the ComB family.

456163:AV541 RS02510
gene id: 456163:AV541_RS02510
uniprot id: A0A0X8D8E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

456163:AV541 RS07010
gene id: 456163:AV541_RS07010
uniprot id: A0A109QEM3
names: Similarity
messages: Belongs to the DapA family.

456163:AV541 RS06265
gene id: 456163:AV541_RS06265
uniprot id: A0A109QJV2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

456163:AV541 RS06385
gene id: 456163:AV541_RS06385
uniprot id: A0A0X8D7E0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

456163:AV541 RS01035
gene id: 456163:AV541_RS01035
uniprot id: H7GIQ7
names: Similarity
messages: Belongs to the peptidase C56 family.

456163:AV541 RS04510
gene id: 456163:AV541_RS04510
uniprot id: H7GEN7
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

456163:AV541 RS08025
gene id: 456163:AV541_RS08025
uniprot id: A0A0X8D8M5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

456163:AV541 RS01405
gene id: 456163:AV541_RS01405
uniprot id: A0A0X8D754
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS01830
gene id: 456163:AV541_RS01830
uniprot id: A0A0X8D788
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

456163:AV541 RS05545
gene id: 456163:AV541_RS05545
uniprot id: H7GGE1
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS06160
gene id: 456163:AV541_RS06160
uniprot id: H7GDT9
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

456163:AV541 RS02955
gene id: 456163:AV541_RS02955
uniprot id: A0A0X8DCA1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS02775
gene id: 456163:AV541_RS02775
uniprot id: A0A0X8D7I0
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

456163:AV541 RS09905
gene id: 456163:AV541_RS09905
uniprot id: A0A0X8D8C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

456163:AV541 RS00240
gene id: 456163:AV541_RS00240
uniprot id: A0A0X8D6W1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

456163:AV541 RS02915
gene id: 456163:AV541_RS02915
uniprot id: A0A0X8D8F0
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

456163:AV541 RS10480
gene id: 456163:AV541_RS10480
uniprot id: A0A0X8DDX0
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

456163:AV541 RS04220
gene id: 456163:AV541_RS04220
uniprot id: A0A0X8D7J7
names: Subcellular Location Annotation
messages: Membrane

456163:AV541 RS08785
gene id: 456163:AV541_RS08785
uniprot id: A0A0X8D9S3
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

456163:AV541 RS07895
gene id: 456163:AV541_RS07895
uniprot id: A0A0X8D889
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

456163:AV541 RS02420
gene id: 456163:AV541_RS02420
uniprot id: H7GI59
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

456163:AV541 RS01695
gene id: 456163:AV541_RS01695
uniprot id: A0A0X8D657
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

456163:AV541 RS01905
gene id: 456163:AV541_RS01905
uniprot id: A0A0X8D676
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

456163:AV541 RS01075
gene id: 456163:AV541_RS01075
uniprot id: A0A109QJH6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

456163:AV541 RS01870
gene id: 456163:AV541_RS01870
uniprot id: A0A0X8DC53
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

456163:AV541 RS09445
gene id: 456163:AV541_RS09445
uniprot id: A0A0X8D9Y6
names: Similarity
messages: Belongs to the DEAD box helicase family.

456163:AV541 RS04365
gene id: 456163:AV541_RS04365
uniprot id: H7GGU5
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

456163:AV541 RS07515
gene id: 456163:AV541_RS07515
uniprot id: A0A0X8D8P0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 1 family.
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

456163:AV541 RS00495
gene id: 456163:AV541_RS00495
uniprot id: A0A0X8DBY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

456163:AV541 RS02325
gene id: 456163:AV541_RS02325
uniprot id: A0A0X8D799
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

456163:AV541 RS06840
gene id: 456163:AV541_RS06840
uniprot id: A0A0X8D8H9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

456163:AV541 RS06435
gene id: 456163:AV541_RS06435
uniprot id: A0A109QIL0
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).

456163:AV541 RS00330
gene id: 456163:AV541_RS00330
uniprot id: A0A0X8D6A7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

456163:AV541 RS02650
gene id: 456163:AV541_RS02650
uniprot id: H7GHQ0
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

456163:AV541 RS02085
gene id: 456163:AV541_RS02085
uniprot id: A0A0X8DC63
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

456163:AV541 RS01765
gene id: 456163:AV541_RS01765
uniprot id: H7GID3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.