45286:AW171 hschr31313
gene id: 45286:AW171_hschr31313
uniprot id: A0A109UVT5
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr31453
gene id: 45286:AW171_hschr31453
uniprot id: A0A109UY54
names: Similarity
messages: Belongs to the NOC2 family.

45286:AW171 hschr84954
gene id: 45286:AW171_hschr84954
uniprot id: A0A120K2X2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ran family.
messages: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.
messages: Nucleus

45286:AW171 hschr84817
gene id: 45286:AW171_hschr84817
uniprot id: A0A0X8HWL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

45286:AW171 hschr21137
gene id: 45286:AW171_hschr21137
uniprot id: A0A109UY76
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.

45286:AW171 hschr74034
gene id: 45286:AW171_hschr74034
uniprot id: A0A0X8HV08
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

45286:AW171 hschr42649
gene id: 45286:AW171_hschr42649
uniprot id: A0A0X8HSP3
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

45286:AW171 hschr31294
gene id: 45286:AW171_hschr31294
uniprot id: A0A120K1J5
names: Similarity
messages: Belongs to the peptidase A1 family.

45286:AW171 hschr53373
gene id: 45286:AW171_hschr53373
uniprot id: A0A109V066
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr74460
gene id: 45286:AW171_hschr74460
uniprot id: A0A109V0E1
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

45286:AW171 hschr31780
gene id: 45286:AW171_hschr31780
uniprot id: A0A109UYJ1
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

45286:AW171 hschr2249
gene id: 45286:AW171_hschr2249
uniprot id: A0A109UWA3
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

45286:AW171 hschr31660
gene id: 45286:AW171_hschr31660
uniprot id: A0A109UZ42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MON1/SAND family.
messages: Prevacuolar compartment membrane
messages: Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.
messages: Vacuole membrane
messages: multivesicular body membrane

45286:AW171 hschr262
gene id: 45286:AW171_hschr262
uniprot id: A0A120K0Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL53 family.
messages: Mitochondrion

45286:AW171 hschr2171
gene id: 45286:AW171_hschr2171
uniprot id: A0A120K0S8
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.

45286:AW171 hschr53089
gene id: 45286:AW171_hschr53089
uniprot id: A0A0X8HTG7
names: Similarity
messages: Belongs to the NXF family.

45286:AW171 hschr42846
gene id: 45286:AW171_hschr42846
uniprot id: A0A0X8HT03
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr84605
gene id: 45286:AW171_hschr84605
uniprot id: A0A0X8HVM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
messages: Mitochondrion inner membrane

45286:AW171 hschr21066
gene id: 45286:AW171_hschr21066
uniprot id: A0A109UXA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

45286:AW171 hschr42415
gene id: 45286:AW171_hschr42415
uniprot id: A0A120K261
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP25 family.
messages: Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.
messages: nucleolus

45286:AW171 hschr42373
gene id: 45286:AW171_hschr42373
uniprot id: A0A0X8HS79
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

45286:AW171 hschr42198
gene id: 45286:AW171_hschr42198
uniprot id: A0A109UWU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2H phosphoesterase superfamily. CPD1 family.
messages: Golgi apparatus
messages: Involved in the metabolism of ADP-ribose 1',2'-cyclic phosphate which is produced as a consequence of tRNA splicing.

45286:AW171 hschr74201
gene id: 45286:AW171_hschr74201
uniprot id: A0A0X8HVH8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

45286:AW171 hschr63932
gene id: 45286:AW171_hschr63932
uniprot id: A0A0X8HV34
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

45286:AW171 hschr53352
gene id: 45286:AW171_hschr53352
uniprot id: A0A0X8HTY2
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

45286:AW171 hschr63564
gene id: 45286:AW171_hschr63564
uniprot id: A0A109UZP4
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr63743
gene id: 45286:AW171_hschr63743
uniprot id: A0A0X8HUJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NCBP1 family.
messages: Nucleus

45286:AW171 hschr74306
gene id: 45286:AW171_hschr74306
uniprot id: A0A0X8HVQ9
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr21123
gene id: 45286:AW171_hschr21123
uniprot id: A0A109UVG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the esterase D family.
messages: Cytoplasm
messages: Serine hydrolase involved in the detoxification of formaldehyde.

45286:AW171 hschr42814
gene id: 45286:AW171_hschr42814
uniprot id: A0A109UZC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

45286:AW171 hschr2159
gene id: 45286:AW171_hschr2159
uniprot id: A0A120K0S7
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

45286:AW171 hschr63797
gene id: 45286:AW171_hschr63797
uniprot id: A0A0X8HUP7
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

45286:AW171 hschr42667
gene id: 45286:AW171_hschr42667
uniprot id: A0A0X8HSP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM21 family.
messages: Involved in mitochondrial migration along actin filaments.
messages: actin patch

45286:AW171 hschr42441
gene id: 45286:AW171_hschr42441
uniprot id: A0A0X8HRA9
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

45286:AW171 hschr42233
gene id: 45286:AW171_hschr42233
uniprot id: A0A0X8HRX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

45286:AW171 hschr42306
gene id: 45286:AW171_hschr42306
uniprot id: A0A109UYU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

45286:AW171 hschr63622
gene id: 45286:AW171_hschr63622
uniprot id: A0A109UZV9
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

45286:AW171 hschr21089
gene id: 45286:AW171_hschr21089
uniprot id: A0A109UY42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family.
messages: Mitochondrion
messages: N-acetylglutamate synthase involved in arginine biosynthesis.

45286:AW171 hschr84670
gene id: 45286:AW171_hschr84670
uniprot id: A0A120K2U0
names: Similarity
messages: Belongs to the WrbA family.

45286:AW171 hschr32009
gene id: 45286:AW171_hschr32009
uniprot id: A0A0X8HRL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane
messages: Required for vacuolar protein sorting.

45286:AW171 hschr74373
gene id: 45286:AW171_hschr74373
uniprot id: A0A0X8HVM2
names: Similarity
messages: Belongs to the PrpD family.

45286:AW171 hschr42356
gene id: 45286:AW171_hschr42356
uniprot id: A0A120K255
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.
messages: Nucleus
messages: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.
messages: telomere

45286:AW171 hschr42185
gene id: 45286:AW171_hschr42185
uniprot id: A0A0X8HRU1
names: Function
names: Similarity
messages: Belongs to the phytoene/squalene synthase family.
messages: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.

45286:AW171 hschr42514
gene id: 45286:AW171_hschr42514
uniprot id: A0A0X8HSG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

45286:AW171 hschr2189
gene id: 45286:AW171_hschr2189
uniprot id: A0A120K0U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

45286:AW171 hschr31439
gene id: 45286:AW171_hschr31439
uniprot id: A0A109UY22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit J family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

45286:AW171 hschr53060
gene id: 45286:AW171_hschr53060
uniprot id: A0A0X8HTB2
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

45286:AW171 hschr74289
gene id: 45286:AW171_hschr74289
uniprot id: A0A120K2Q2
names: Function
names: Similarity
messages: Belongs to the UDPGP type 1 family.
messages: Plays a central role as a glucosyl donor in cellular metabolic pathways.

45286:AW171 hschr2313
gene id: 45286:AW171_hschr2313
uniprot id: A0A120K0Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SHE3 family.
messages: Endoplasmic reticulum membrane
messages: RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell. Required for the delivery of cortical endoplasmic reticulum into the emerging bud.

45286:AW171 hschr85016
gene id: 45286:AW171_hschr85016
uniprot id: A0A0X8HWV8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

45286:AW171 hschr42730
gene id: 45286:AW171_hschr42730
uniprot id: A0A0X8HSX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr42728
gene id: 45286:AW171_hschr42728
uniprot id: A0A0X8HST8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase B chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane

45286:AW171 hschr53160
gene id: 45286:AW171_hschr53160
uniprot id: A0A120K2E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex DAD2 family.
messages: Nucleus
messages: kinetochore
messages: spindle

45286:AW171 hschr63753
gene id: 45286:AW171_hschr63753
uniprot id: A0A120K2K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

45286:AW171 hschr84785
gene id: 45286:AW171_hschr84785
uniprot id: A0A0X8HWJ5
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

45286:AW171 hschr85025
gene id: 45286:AW171_hschr85025
uniprot id: A0A0X8HWU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Forms a complex with TRM82.
messages: Nucleus

45286:AW171 hschr63654
gene id: 45286:AW171_hschr63654
uniprot id: A0A0X8HUG0
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

45286:AW171 hschr84708
gene id: 45286:AW171_hschr84708
uniprot id: A0A0X8HW74
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.

45286:AW171 hschr42502
gene id: 45286:AW171_hschr42502
uniprot id: A0A0X8HSB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

45286:AW171 hschr84619
gene id: 45286:AW171_hschr84619
uniprot id: A0A0X8HW48
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAC-beta family.
messages: Cytoplasm
messages: Nucleus
messages: Part of the nascent polypeptide-associated complex (NAC).

45286:AW171 hschr42425
gene id: 45286:AW171_hschr42425
uniprot id: A0A0X8HS91
names: Similarity
messages: Belongs to the PIGH family.

45286:AW171 hschr53066
gene id: 45286:AW171_hschr53066
uniprot id: A0A109UZB6
names: Similarity
messages: Belongs to the peptidase A1 family.

45286:AW171 hschr63830
gene id: 45286:AW171_hschr63830
uniprot id: A0A0X8HUN6
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

45286:AW171 hschr2195
gene id: 45286:AW171_hschr2195
uniprot id: A0A109UWB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

45286:AW171 hschr42381
gene id: 45286:AW171_hschr42381
uniprot id: A0A109UZ34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP14 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
messages: nucleolus

45286:AW171 hschr52960
gene id: 45286:AW171_hschr52960
uniprot id: A0A0X8HT80
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

45286:AW171 hschr31656
gene id: 45286:AW171_hschr31656
uniprot id: A0A109UYA4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

45286:AW171 hschr63813
gene id: 45286:AW171_hschr63813
uniprot id: A0A0X8HU23
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

45286:AW171 hschr53097
gene id: 45286:AW171_hschr53097
uniprot id: A0A0X8HTF6
names: Similarity
messages: Belongs to the AAA ATPase family.

45286:AW171 hschr288
gene id: 45286:AW171_hschr288
uniprot id: A0A109UVY5
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr31686
gene id: 45286:AW171_hschr31686
uniprot id: A0A109UYA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

45286:AW171 hschr42741
gene id: 45286:AW171_hschr42741
uniprot id: A0A120K293
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC16 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.
messages: Membrane

45286:AW171 hschr2442
gene id: 45286:AW171_hschr2442
uniprot id: A0A120K121
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

45286:AW171 hschr31588
gene id: 45286:AW171_hschr31588
uniprot id: A0A109UYN0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr63496
gene id: 45286:AW171_hschr63496
uniprot id: A0A120K2H0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

45286:AW171 hschr31498
gene id: 45286:AW171_hschr31498
uniprot id: A0A109UYU5
names: Similarity
messages: Belongs to the glycosyl hydrolase 76 family.

45286:AW171 hschr74448
gene id: 45286:AW171_hschr74448
uniprot id: A0A109UY85
names: Similarity
messages: Belongs to the sorting nexin family.

45286:AW171 hschr42818
gene id: 45286:AW171_hschr42818
uniprot id: A0A109UZ72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAR5 family.
messages: Endoplasmic reticulum membrane
messages: Nucleus membrane
messages: Required for nuclear membrane fusion during karyogamy.

45286:AW171 hschr53069
gene id: 45286:AW171_hschr53069
uniprot id: A0A120K2C8
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

45286:AW171 hschr42248
gene id: 45286:AW171_hschr42248
uniprot id: A0A0X8HRZ0
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr2843
gene id: 45286:AW171_hschr2843
uniprot id: A0A120K156
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

45286:AW171 hschr74401
gene id: 45286:AW171_hschr74401
uniprot id: A0A109UY73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

45286:AW171 hschr85011
gene id: 45286:AW171_hschr85011
uniprot id: A0A0X8HWY3
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

45286:AW171 hschr53400
gene id: 45286:AW171_hschr53400
uniprot id: A0A0X8HTZ2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Heterooctamer of 4 alpha and 4 beta chains.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

45286:AW171 hschr74207
gene id: 45286:AW171_hschr74207
uniprot id: A0A0X8HVB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKN1/KRE6 family.
messages: Membrane

45286:AW171 hschr31629
gene id: 45286:AW171_hschr31629
uniprot id: A0A109UYG9
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

45286:AW171 hschr42368
gene id: 45286:AW171_hschr42368
uniprot id: A0A120K256
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

45286:AW171 hschr84938
gene id: 45286:AW171_hschr84938
uniprot id: A0A109V0U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Nucleus

45286:AW171 hschr42451
gene id: 45286:AW171_hschr42451
uniprot id: A0A0X8HSC0
names: Similarity
messages: Belongs to the BolA/IbaG family.

45286:AW171 hschr279
gene id: 45286:AW171_hschr279
uniprot id: A0A109UVY3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Membrane
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.

45286:AW171 hschr53245
gene id: 45286:AW171_hschr53245
uniprot id: A0A109UXG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
messages: In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.
messages: Nucleus
messages: Responsible for methylating the 5'-cap structure of mRNAs.

45286:AW171 hschr74136
gene id: 45286:AW171_hschr74136
uniprot id: A0A109V001
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
messages: Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
messages: nucleolus

45286:AW171 hschr84990
gene id: 45286:AW171_hschr84990
uniprot id: A0A0X8HWS2
names: Cofactor
names: Function
names: Similarity
messages: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
messages: Belongs to the tRNA(His) guanylyltransferase family.
messages: Binds 2 magnesium ions per subunit.

45286:AW171 hschr31538
gene id: 45286:AW171_hschr31538
uniprot id: A0A109UYB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MET18/MMS19 family.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus

45286:AW171 hschr63980
gene id: 45286:AW171_hschr63980
uniprot id: A0A0X8HUX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Membrane
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.

45286:AW171 hschr2469
gene id: 45286:AW171_hschr2469
uniprot id: A0A109UWN5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

45286:AW171 hschr31867
gene id: 45286:AW171_hschr31867
uniprot id: A0A0X8HR98
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

45286:AW171 hschr253
gene id: 45286:AW171_hschr253
uniprot id: A0A109UW21
names: Subcellular Location Annotation
messages: nucleolus

45286:AW171 hschr53372
gene id: 45286:AW171_hschr53372
uniprot id: A0A109UXI4
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr84556
gene id: 45286:AW171_hschr84556
uniprot id: A0A0X8HW46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr42388
gene id: 45286:AW171_hschr42388
uniprot id: A0A0X8HS95
names: Similarity
messages: Belongs to the ketopantoate reductase family.

45286:AW171 hschr21214
gene id: 45286:AW171_hschr21214
uniprot id: A0A109UVM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr63890
gene id: 45286:AW171_hschr63890
uniprot id: A0A120K2L2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: Nucleus

45286:AW171 hschr63662
gene id: 45286:AW171_hschr63662
uniprot id: A0A109V0C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr74191
gene id: 45286:AW171_hschr74191
uniprot id: A0A109V012
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

45286:AW171 hschr84899
gene id: 45286:AW171_hschr84899
uniprot id: A0A0X8HWN4
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

45286:AW171 hschr63849
gene id: 45286:AW171_hschr63849
uniprot id: A0A0X8HUP8
names: Similarity
messages: Belongs to the peptidase C19 family.

45286:AW171 hschr53432
gene id: 45286:AW171_hschr53432
uniprot id: A0A109UZI3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

45286:AW171 hschr63778
gene id: 45286:AW171_hschr63778
uniprot id: A0A0X8HUS3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

45286:AW171 hschr84946
gene id: 45286:AW171_hschr84946
uniprot id: A0A0X8HWA6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS30 family.

45286:AW171 hschr42641
gene id: 45286:AW171_hschr42641
uniprot id: A0A0X8HSP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr53041
gene id: 45286:AW171_hschr53041
uniprot id: A0A109V000
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex SPC19 family.
messages: Nucleus
messages: kinetochore

45286:AW171 hschr84559
gene id: 45286:AW171_hschr84559
uniprot id: A0A0X8HVI9
names: Subunit
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

45286:AW171 hschr31959
gene id: 45286:AW171_hschr31959
uniprot id: A0A0X8HRF8
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL41 family.
messages: Component of the large ribosomal subunit.

45286:AW171 hschr31992
gene id: 45286:AW171_hschr31992
uniprot id: A0A0X8HRJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
messages: Endoplasmic reticulum membrane

45286:AW171 hschr42796
gene id: 45286:AW171_hschr42796
uniprot id: A0A0X8HSY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSM3 family.
messages: Component of the fork protection complex (FPC) consisting of TOF1 and CSM3.
messages: Nucleus
messages: Plays an important role in the control of DNA replication and the maintenance of replication fork stability.

45286:AW171 hschr74061
gene id: 45286:AW171_hschr74061
uniprot id: A0A109V0K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

45286:AW171 hschr85036
gene id: 45286:AW171_hschr85036
uniprot id: A0A109V0H6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RSA3 family.
messages: Required for efficient biogenesis of the 60S ribosomal subunit.
messages: nucleolus

45286:AW171 hschr84727
gene id: 45286:AW171_hschr84727
uniprot id: A0A0X8HVV1
names: Function
names: Similarity
messages: Belongs to the IRC6 family.
messages: Involved in gross chromosomal rearrangements (GCRs) and telomere healing.

45286:AW171 hschr31866
gene id: 45286:AW171_hschr31866
uniprot id: A0A109UYZ5
names: Similarity
messages: Belongs to the RutC family.

45286:AW171 hschr74413
gene id: 45286:AW171_hschr74413
uniprot id: A0A109V0D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

45286:AW171 hschr53018
gene id: 45286:AW171_hschr53018
uniprot id: A0A0X8HTA7
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

45286:AW171 hschr21021
gene id: 45286:AW171_hschr21021
uniprot id: A0A109UXB1
names: Function
names: Similarity
messages: Belongs to the RRF family.
messages: Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.

45286:AW171 hschr53012
gene id: 45286:AW171_hschr53012
uniprot id: A0A0X8HTC3
names: Similarity
messages: Belongs to the DCP1 family.

45286:AW171 hschr84952
gene id: 45286:AW171_hschr84952
uniprot id: A0A120K2X5
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

45286:AW171 hschr85058
gene id: 45286:AW171_hschr85058
uniprot id: A0A0X8HWV9
names: Similarity
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Homooctamer.

45286:AW171 hschr261
gene id: 45286:AW171_hschr261
uniprot id: A0A120K0P5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with 90S and pre-40S pre-ribosomal particles.
messages: Belongs to the RRP36 family.
messages: Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
messages: nucleolus

45286:AW171 hschr74228
gene id: 45286:AW171_hschr74228
uniprot id: A0A0X8HVD9
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

45286:AW171 hschr42495
gene id: 45286:AW171_hschr42495
uniprot id: A0A120K270
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

45286:AW171 hschr53228
gene id: 45286:AW171_hschr53228
uniprot id: A0A109UZH5
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.

45286:AW171 hschr84684
gene id: 45286:AW171_hschr84684
uniprot id: A0A109V096
names: Function
names: Similarity
messages: 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

45286:AW171 hschr31499
gene id: 45286:AW171_hschr31499
uniprot id: A0A109UY93
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

45286:AW171 hschr74365
gene id: 45286:AW171_hschr74365
uniprot id: A0A109V063
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

45286:AW171 hschr84949
gene id: 45286:AW171_hschr84949
uniprot id: A0A0X8HWP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. LepA subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Mitochondrion inner membrane
messages: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.

45286:AW171 hschr42085
gene id: 45286:AW171_hschr42085
uniprot id: A0A0X8HRP1
names: Function
names: Similarity
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.

45286:AW171 hschr31618
gene id: 45286:AW171_hschr31618
uniprot id: A0A109UYP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STE12 transcription factor family.
messages: Nucleus

45286:AW171 hschr21074
gene id: 45286:AW171_hschr21074
uniprot id: A0A109UXB3
names: Similarity
messages: Belongs to the eIF-2-alpha family.

45286:AW171 hschr21176
gene id: 45286:AW171_hschr21176
uniprot id: A0A120K1G0
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

45286:AW171 hschr42600
gene id: 45286:AW171_hschr42600
uniprot id: A0A0X8HSJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Required for proper protein synthesis within the mitochondrion.
messages: Belongs to the GatF family.
messages: Mitochondrion inner membrane
messages: Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A, B and F subunits.

45286:AW171 hschr53003
gene id: 45286:AW171_hschr53003
uniprot id: A0A0X8HT98
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.

45286:AW171 hschr21282
gene id: 45286:AW171_hschr21282
uniprot id: A0A109UXP1
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

45286:AW171 hschr53116
gene id: 45286:AW171_hschr53116
uniprot id: A0A120K2D6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG7 family.
messages: Cytoplasm
messages: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.
messages: Homodimer.
messages: Preautophagosomal structure

45286:AW171 hschr84812
gene id: 45286:AW171_hschr84812
uniprot id: A0A120K2V6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

45286:AW171 hschr2533
gene id: 45286:AW171_hschr2533
uniprot id: A0A109UX94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat TRM82 family.
messages: Nucleus
messages: Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

45286:AW171 hschr52874
gene id: 45286:AW171_hschr52874
uniprot id: A0A0X8HT42
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.

45286:AW171 hschr63609
gene id: 45286:AW171_hschr63609
uniprot id: A0A120K2I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

45286:AW171 hschr31380
gene id: 45286:AW171_hschr31380
uniprot id: A0A109UYB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Vacuole membrane

45286:AW171 hschr2877
gene id: 45286:AW171_hschr2877
uniprot id: A0A120K168
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS37 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit.
messages: Mitochondrion

45286:AW171 hschr84666
gene id: 45286:AW171_hschr84666
uniprot id: A0A0X8HVR1
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr85018
gene id: 45286:AW171_hschr85018
uniprot id: A0A0X8HWV6
names: Function
names: Subcellular Location Annotation
messages: Acts as component of the general transcription and DNA repair factor IIH (TFIIH or factor B), which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA.
messages: Nucleus

45286:AW171 hschr53039
gene id: 45286:AW171_hschr53039
uniprot id: A0A109UZE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ4 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
messages: Mitochondrion inner membrane

45286:AW171 hschr31502
gene id: 45286:AW171_hschr31502
uniprot id: A0A109UY28
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.

45286:AW171 hschr2447
gene id: 45286:AW171_hschr2447
uniprot id: A0A120K115
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

45286:AW171 hschr53388
gene id: 45286:AW171_hschr53388
uniprot id: A0A109UZJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBP1 family.
messages: Component of the spindle pole body (SPB) required for insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication. Connects the central plaque of the SPB with the half-bridge. Required for proper localization of CDC5 at the SPB and for proper M-phase progression.
messages: spindle pole body

45286:AW171 hschr52930
gene id: 45286:AW171_hschr52930
uniprot id: A0A120K2B5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

45286:AW171 hschr52993
gene id: 45286:AW171_hschr52993
uniprot id: A0A120K2B9
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

45286:AW171 hschr53147
gene id: 45286:AW171_hschr53147
uniprot id: A0A109UZE2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

45286:AW171 hschr42335
gene id: 45286:AW171_hschr42335
uniprot id: A0A0X8HS36
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

45286:AW171 hschr63698
gene id: 45286:AW171_hschr63698
uniprot id: A0A0X8HUE4
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr42601
gene id: 45286:AW171_hschr42601
uniprot id: A0A0X8HRT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pescadillo family.
messages: Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.
messages: Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

45286:AW171 hschr42476
gene id: 45286:AW171_hschr42476
uniprot id: A0A0X8HSB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
messages: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
messages: nucleolus

45286:AW171 hschr52975
gene id: 45286:AW171_hschr52975
uniprot id: A0A0X8HT89
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PLPL family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lipid hydrolase.
messages: Membrane

45286:AW171 hschr31702
gene id: 45286:AW171_hschr31702
uniprot id: A0A120K1X7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

45286:AW171 hschr63612
gene id: 45286:AW171_hschr63612
uniprot id: A0A109V0B6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

45286:AW171 hschr42664
gene id: 45286:AW171_hschr42664
uniprot id: A0A0X8HSL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.
messages: Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.
messages: Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.
messages: Nucleus

45286:AW171 hschr31436
gene id: 45286:AW171_hschr31436
uniprot id: A0A109UW13
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

45286:AW171 hschr21011
gene id: 45286:AW171_hschr21011
uniprot id: A0A125RE22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

45286:AW171 hschr31743
gene id: 45286:AW171_hschr31743
uniprot id: A0A0X8HR28
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

45286:AW171 hschr53401
gene id: 45286:AW171_hschr53401
uniprot id: A0A120K2G4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

45286:AW171 hschr52950
gene id: 45286:AW171_hschr52950
uniprot id: A0A109UXA1
names: Similarity
messages: Belongs to the FGGY kinase family.

45286:AW171 hschr42133
gene id: 45286:AW171_hschr42133
uniprot id: A0A109UYM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CybS family.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr31887
gene id: 45286:AW171_hschr31887
uniprot id: A0A0X8HRD3
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.

45286:AW171 hschr53454
gene id: 45286:AW171_hschr53454
uniprot id: A0A0X8HU05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reverse transcriptase family. Telomerase subfamily.
messages: Nucleus
messages: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
messages: telomere

45286:AW171 hschr31718
gene id: 45286:AW171_hschr31718
uniprot id: A0A120K1Y3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
messages: Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Nucleus

45286:AW171 hschr74169
gene id: 45286:AW171_hschr74169
uniprot id: A0A0X8HVF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

45286:AW171 hschr2961
gene id: 45286:AW171_hschr2961
uniprot id: A0A109UX86
names: Function
names: Similarity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.

45286:AW171 hschr63708
gene id: 45286:AW171_hschr63708
uniprot id: A0A109UXR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

45286:AW171 hschr52893
gene id: 45286:AW171_hschr52893
uniprot id: A0A0X8HT52
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

45286:AW171 hschr42721
gene id: 45286:AW171_hschr42721
uniprot id: A0A0X8HSS2
names: Similarity
messages: Belongs to the AAA ATPase family.

45286:AW171 hschr31856
gene id: 45286:AW171_hschr31856
uniprot id: A0A0X8HRB2
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
messages: Can also use Mn(2+) ion.

45286:AW171 hschr84808
gene id: 45286:AW171_hschr84808
uniprot id: A0A0X8HWE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS53 family.
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

45286:AW171 hschr74393
gene id: 45286:AW171_hschr74393
uniprot id: A0A0X8HVT9
names: Function
names: Similarity
messages: Belongs to the SNU71 family.
messages: Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway.

45286:AW171 hschr31997
gene id: 45286:AW171_hschr31997
uniprot id: A0A0X8HQI7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

45286:AW171 hschr74486
gene id: 45286:AW171_hschr74486
uniprot id: A0A0X8HW00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

45286:AW171 hschr63649
gene id: 45286:AW171_hschr63649
uniprot id: A0A0X8HUK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Part of the multisubunit TRAPP (transport protein particle) complex.
messages: Plays a key role in the late stages of endoplasmic reticulum to Golgi traffic.
messages: cis-Golgi network

45286:AW171 hschr74345
gene id: 45286:AW171_hschr74345
uniprot id: A0A109V017
names: Similarity
messages: Belongs to the BLM10 family.

45286:AW171 hschr53093
gene id: 45286:AW171_hschr53093
uniprot id: A0A0X8HTF4
names: Function
messages: Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

45286:AW171 hschr84970
gene id: 45286:AW171_hschr84970
uniprot id: A0A109UYN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

45286:AW171 hschr74233
gene id: 45286:AW171_hschr74233
uniprot id: A0A0X8HVJ5
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr2111
gene id: 45286:AW171_hschr2111
uniprot id: A0A109UW03
names: Similarity
messages: Belongs to the replication factor A protein 2 family.

45286:AW171 hschr74286
gene id: 45286:AW171_hschr74286
uniprot id: A0A120K2Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.
messages: Cell membrane
messages: The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.

45286:AW171 hschr74348
gene id: 45286:AW171_hschr74348
uniprot id: A0A109V057
names: Cofactor
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.

45286:AW171 hschr2123
gene id: 45286:AW171_hschr2123
uniprot id: A0A120K0R7
names: Function
names: Similarity
messages: Belongs to the methyltransferase TRM13 family.
messages: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

45286:AW171 hschr228
gene id: 45286:AW171_hschr228
uniprot id: A0A120K0N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

45286:AW171 hschr53079
gene id: 45286:AW171_hschr53079
uniprot id: A0A0X8HSQ0
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

45286:AW171 hschr42334
gene id: 45286:AW171_hschr42334
uniprot id: A0A0X8HR31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr53056
gene id: 45286:AW171_hschr53056
uniprot id: A0A109UZP5
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

45286:AW171 hschr84748
gene id: 45286:AW171_hschr84748
uniprot id: A0A109V0F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

45286:AW171 hschr84916
gene id: 45286:AW171_hschr84916
uniprot id: A0A0X8HWP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BMT2 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.
messages: nucleolus

45286:AW171 hschr53335
gene id: 45286:AW171_hschr53335
uniprot id: A0A0X8HTW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. SAR1 family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

45286:AW171 hschr85008
gene id: 45286:AW171_hschr85008
uniprot id: A0A120K2X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LU7TM family.
messages: Membrane

45286:AW171 hschr74097
gene id: 45286:AW171_hschr74097
uniprot id: A0A0X8HV43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG8 family.
messages: Membrane

45286:AW171 hschr63725
gene id: 45286:AW171_hschr63725
uniprot id: A0A0X8HUJ4
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr84566
gene id: 45286:AW171_hschr84566
uniprot id: A0A109V0L0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ISN1 family.
messages: Homotetramer.
messages: IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation.

45286:AW171 hschr31536
gene id: 45286:AW171_hschr31536
uniprot id: A0A109UW68
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr2168
gene id: 45286:AW171_hschr2168
uniprot id: A0A109UW38
names: Similarity
messages: Belongs to the ZPR1 family.

45286:AW171 hschr2840
gene id: 45286:AW171_hschr2840
uniprot id: A0A109UWV0
names: Similarity
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.

45286:AW171 hschr31630
gene id: 45286:AW171_hschr31630
uniprot id: A0A109UYC6
names: Similarity
messages: Belongs to the AB hydrolase superfamily. MetX family.

45286:AW171 hschr63908
gene id: 45286:AW171_hschr63908
uniprot id: A0A109UZR2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

45286:AW171 hschr42348
gene id: 45286:AW171_hschr42348
uniprot id: A0A0X8HS40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

45286:AW171 hschr21233
gene id: 45286:AW171_hschr21233
uniprot id: A0A109UXN9
names: Similarity
messages: Belongs to the FAH family.

45286:AW171 hschr63943
gene id: 45286:AW171_hschr63943
uniprot id: A0A120K2M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

45286:AW171 hschr21208
gene id: 45286:AW171_hschr21208
uniprot id: A0A120K1H2
names: Similarity
messages: Belongs to the actin family.

45286:AW171 hschr31383
gene id: 45286:AW171_hschr31383
uniprot id: A0A120K1M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

45286:AW171 hschr42363
gene id: 45286:AW171_hschr42363
uniprot id: A0A0X8HS50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 19 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

45286:AW171 hschr42803
gene id: 45286:AW171_hschr42803
uniprot id: A0A109UX70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

45286:AW171 hschr63498
gene id: 45286:AW171_hschr63498
uniprot id: A0A120K2H4
names: Similarity
messages: Belongs to the glycosyltransferase 15 family.

45286:AW171 hschr21162
gene id: 45286:AW171_hschr21162
uniprot id: A0A120K1F7
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.

45286:AW171 hschr84908
gene id: 45286:AW171_hschr84908
uniprot id: A0A0X8HWL9
names: Similarity
messages: Belongs to the MNN1/MNT family.

45286:AW171 hschr53177
gene id: 45286:AW171_hschr53177
uniprot id: A0A109UXE6
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

45286:AW171 hschr42526
gene id: 45286:AW171_hschr42526
uniprot id: A0A109UYZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.
messages: Membrane
messages: Vacuole membrane

45286:AW171 hschr63722
gene id: 45286:AW171_hschr63722
uniprot id: A0A109UXR7
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

45286:AW171 hschr63828
gene id: 45286:AW171_hschr63828
uniprot id: A0A0X8HUW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

45286:AW171 hschr2122
gene id: 45286:AW171_hschr2122
uniprot id: A0A120K0R4
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.

45286:AW171 hschr2329
gene id: 45286:AW171_hschr2329
uniprot id: A0A120K0Y0
names: Similarity
messages: Belongs to the PHF5 family.

45286:AW171 hschr63852
gene id: 45286:AW171_hschr63852
uniprot id: A0A0X8HUS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

45286:AW171 hschr53274
gene id: 45286:AW171_hschr53274
uniprot id: A0A109UZD1
names: Activity Regulation
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. PAN2 subfamily.
messages: Binds 2 metal cations per subunit in the catalytic exonuclease domain.
messages: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
messages: Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.
messages: Cytoplasm
messages: Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Positively regulated by the regulatory subunit PAN3.
messages: The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.

45286:AW171 hschr2492
gene id: 45286:AW171_hschr2492
uniprot id: A0A120K134
names: Similarity
messages: Belongs to the SLX4 family.

45286:AW171 hschr74057
gene id: 45286:AW171_hschr74057
uniprot id: A0A0X8HV18
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

45286:AW171 hschr31469
gene id: 45286:AW171_hschr31469
uniprot id: A0A109UY67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

45286:AW171 hschr42742
gene id: 45286:AW171_hschr42742
uniprot id: A0A0X8HSU9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.

45286:AW171 hschr53462
gene id: 45286:AW171_hschr53462
uniprot id: A0A120K2H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERCC1/RAD10/SWI10 family.
messages: Nucleus

45286:AW171 hschr32046
gene id: 45286:AW171_hschr32046
uniprot id: A0A0X8HRM3
names: Similarity
messages: Belongs to the MYBBP1A family.

45286:AW171 hschr31703
gene id: 45286:AW171_hschr31703
uniprot id: A0A109UYH6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

45286:AW171 hschr42341
gene id: 45286:AW171_hschr42341
uniprot id: A0A109UZ98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A, B and F subunits.

45286:AW171 hschr42454
gene id: 45286:AW171_hschr42454
uniprot id: A0A0X8HSD4
names: Function
names: Similarity
messages: Belongs to the peptidase T1A family.
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

45286:AW171 hschr2524
gene id: 45286:AW171_hschr2524
uniprot id: A0A109UWS4
names: Function
names: Similarity
messages: Belongs to the CWC15 family.
messages: Involved in pre-mRNA splicing.

45286:AW171 hschr31556
gene id: 45286:AW171_hschr31556
uniprot id: A0A109UY55
names: Similarity
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.

45286:AW171 hschr42098
gene id: 45286:AW171_hschr42098
uniprot id: A0A0X8HRQ5
names: Similarity
messages: Belongs to the oligoribonuclease family.

45286:AW171 hschr31736
gene id: 45286:AW171_hschr31736
uniprot id: A0A120K1Z1
names: Similarity
messages: Belongs to the MT-A70-like family.

45286:AW171 hschr63889
gene id: 45286:AW171_hschr63889
uniprot id: A0A0X8HUS6
names: Similarity
messages: Belongs to the Rab GDI family.

45286:AW171 hschr74456
gene id: 45286:AW171_hschr74456
uniprot id: A0A0X8HVY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

45286:AW171 hschr42496
gene id: 45286:AW171_hschr42496
uniprot id: A0A120K269
names: Similarity
messages: Belongs to the pyridoxine kinase family.

45286:AW171 hschr63901
gene id: 45286:AW171_hschr63901
uniprot id: A0A0X8HUV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
messages: Membrane

45286:AW171 hschr42421
gene id: 45286:AW171_hschr42421
uniprot id: A0A0X8HSA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

45286:AW171 hschr53303
gene id: 45286:AW171_hschr53303
uniprot id: A0A0X8HTT7
names: Similarity
messages: Belongs to the DEAD box helicase family.

45286:AW171 hschr53465
gene id: 45286:AW171_hschr53465
uniprot id: A0A109V089
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane
messages: May function both as a monomer and a homodimer.

45286:AW171 hschr31475
gene id: 45286:AW171_hschr31475
uniprot id: A0A120K1Q6
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

45286:AW171 hschr2405
gene id: 45286:AW171_hschr2405
uniprot id: A0A109UX14
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr74396
gene id: 45286:AW171_hschr74396
uniprot id: A0A0X8HVR6
names: Similarity
messages: Belongs to the peptidase C19 family.

45286:AW171 hschr31586
gene id: 45286:AW171_hschr31586
uniprot id: A0A109UW98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMP52 family.
messages: Membrane
messages: Mitochondrion outer membrane

45286:AW171 hschr2926
gene id: 45286:AW171_hschr2926
uniprot id: A0A120K178
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

45286:AW171 hschr53397
gene id: 45286:AW171_hschr53397
uniprot id: A0A0X8HTC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 9 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

45286:AW171 hschr53418
gene id: 45286:AW171_hschr53418
uniprot id: A0A109UXJ6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.

45286:AW171 hschr42548
gene id: 45286:AW171_hschr42548
uniprot id: A0A0X8HSH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
messages: Belongs to the CNOT2/3/5 family.
messages: Cytoplasm
messages: Nucleus

45286:AW171 hschr31500
gene id: 45286:AW171_hschr31500
uniprot id: A0A109UY59
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr42152
gene id: 45286:AW171_hschr42152
uniprot id: A0A109UYS3
names: Similarity
messages: Belongs to the glycosyltransferase 32 family.

45286:AW171 hschr42194
gene id: 45286:AW171_hschr42194
uniprot id: A0A0X8HRV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U48 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr84891
gene id: 45286:AW171_hschr84891
uniprot id: A0A109V0I3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.

45286:AW171 hschr31842
gene id: 45286:AW171_hschr31842
uniprot id: A0A0X8HR92
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

45286:AW171 hschr31392
gene id: 45286:AW171_hschr31392
uniprot id: A0A109UXZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

45286:AW171 hschr42168
gene id: 45286:AW171_hschr42168
uniprot id: A0A120K235
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: This promotes the activity of RNA polymerase II.

45286:AW171 hschr31763
gene id: 45286:AW171_hschr31763
uniprot id: A0A0X8HQ43
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

45286:AW171 hschr31730
gene id: 45286:AW171_hschr31730
uniprot id: A0A109UYW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

45286:AW171 hschr85014
gene id: 45286:AW171_hschr85014
uniprot id: A0A0X8HWZ7
names: Similarity
messages: Belongs to the AAA ATPase family.

45286:AW171 hschr84943
gene id: 45286:AW171_hschr84943
uniprot id: A0A0X8HWV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.

45286:AW171 hschr42748
gene id: 45286:AW171_hschr42748
uniprot id: A0A0X8HST7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

45286:AW171 hschr42086
gene id: 45286:AW171_hschr42086
uniprot id: A0A109UYL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr63545
gene id: 45286:AW171_hschr63545
uniprot id: A0A120K2H5
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

45286:AW171 hschr31847
gene id: 45286:AW171_hschr31847
uniprot id: A0A120K1Z9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIS1 family.
messages: Has a role in mitochondrial fission.
messages: Membrane
messages: Mitochondrion outer membrane
messages: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.

45286:AW171 hschr31347
gene id: 45286:AW171_hschr31347
uniprot id: A0A109UXW0
names: Similarity
messages: In the C-terminal section; belongs to the histidinol dehydrogenase family.

45286:AW171 hschr74352
gene id: 45286:AW171_hschr74352
uniprot id: A0A0X8HVM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

45286:AW171 hschr31986
gene id: 45286:AW171_hschr31986
uniprot id: A0A120K215
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

45286:AW171 hschr42310
gene id: 45286:AW171_hschr42310
uniprot id: A0A120K250
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

45286:AW171 hschr74088
gene id: 45286:AW171_hschr74088
uniprot id: A0A109UZZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

45286:AW171 hschr42237
gene id: 45286:AW171_hschr42237
uniprot id: A0A0X8HS13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASP family.
messages: Golgi apparatus membrane
messages: Membrane

45286:AW171 hschr42084
gene id: 45286:AW171_hschr42084
uniprot id: A0A0X8HQN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

45286:AW171 hschr31805
gene id: 45286:AW171_hschr31805
uniprot id: A0A0X8HR66
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

45286:AW171 hschr84606
gene id: 45286:AW171_hschr84606
uniprot id: A0A0X8HW44
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.

45286:AW171 hschr74027
gene id: 45286:AW171_hschr74027
uniprot id: A0A109UXY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex DAD1 family.
messages: Nucleus
messages: kinetochore
messages: spindle

45286:AW171 hschr42678
gene id: 45286:AW171_hschr42678
uniprot id: A0A0X8HSR0
names: Similarity
messages: Belongs to the TOP6A family.

45286:AW171 hschr42188
gene id: 45286:AW171_hschr42188
uniprot id: A0A0X8HRS8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

45286:AW171 hschr53209
gene id: 45286:AW171_hschr53209
uniprot id: A0A120K2E2
names: Similarity
messages: Belongs to the PP2C family.

45286:AW171 hschr21173
gene id: 45286:AW171_hschr21173
uniprot id: A0A109UXH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family.
messages: Cell membrane
messages: Vacuole membrane

45286:AW171 hschr42228
gene id: 45286:AW171_hschr42228
uniprot id: A0A0X8HRW2
names: Subcellular Location Annotation
messages: Mitochondrion

45286:AW171 hschr42179
gene id: 45286:AW171_hschr42179
uniprot id: A0A109UYN6
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

45286:AW171 hschr21193
gene id: 45286:AW171_hschr21193
uniprot id: A0A120K1G7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

45286:AW171 hschr2878
gene id: 45286:AW171_hschr2878
uniprot id: A0A109UWX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDHAF2 family.
messages: Interacts with the flavoprotein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.

45286:AW171 hschr74112
gene id: 45286:AW171_hschr74112
uniprot id: A0A0X8HV58
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

45286:AW171 hschr74311
gene id: 45286:AW171_hschr74311
uniprot id: A0A0X8HVK7
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr84810
gene id: 45286:AW171_hschr84810
uniprot id: A0A120K2W0
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.

45286:AW171 hschr2385
gene id: 45286:AW171_hschr2385
uniprot id: A0A109UWN7
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

45286:AW171 hschr85035
gene id: 45286:AW171_hschr85035
uniprot id: A0A0X8HWT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCC1 family.
messages: Membrane

45286:AW171 hschr42606
gene id: 45286:AW171_hschr42606
uniprot id: A0A120K280
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
messages: Cytoplasm
messages: Nucleus

45286:AW171 hschr42530
gene id: 45286:AW171_hschr42530
uniprot id: A0A0X8HSH3
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

45286:AW171 hschr2173
gene id: 45286:AW171_hschr2173
uniprot id: A0A120K0U1
names: Similarity
messages: Belongs to the TOG/XMAP215 family.

45286:AW171 hschr31721
gene id: 45286:AW171_hschr31721
uniprot id: A0A109UYI8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.
messages: Membrane
messages: Peroxisome membrane

45286:AW171 hschr53083
gene id: 45286:AW171_hschr53083
uniprot id: A0A120K2D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG29 family.
messages: Preautophagosomal structure

45286:AW171 hschr31890
gene id: 45286:AW171_hschr31890
uniprot id: A0A0X8HQB5
names: Similarity
messages: Belongs to the WD repeat LST8 family.

45286:AW171 hschr85044
gene id: 45286:AW171_hschr85044
uniprot id: A0A0X8HX31
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr31965
gene id: 45286:AW171_hschr31965
uniprot id: A0A0X8HRH5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.

45286:AW171 hschr42190
gene id: 45286:AW171_hschr42190
uniprot id: A0A0X8HRW4
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

45286:AW171 hschr84631
gene id: 45286:AW171_hschr84631
uniprot id: A0A0X8HW29
names: Function
names: Similarity
messages: Belongs to the catalase family.
messages: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.

45286:AW171 hschr84997
gene id: 45286:AW171_hschr84997
uniprot id: A0A0X8HWW1
names: Subcellular Location Annotation
messages: nuclear pore complex

45286:AW171 hschr63576
gene id: 45286:AW171_hschr63576
uniprot id: A0A109UZV0
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

45286:AW171 hschr63508
gene id: 45286:AW171_hschr63508
uniprot id: A0A0X8HU79
names: Similarity
messages: Belongs to the PP2C family.

45286:AW171 hschr2977
gene id: 45286:AW171_hschr2977
uniprot id: A0A109UXA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat CIA1 family.
messages: Cytoplasm
messages: Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.
messages: Interacts with NAR1.
messages: Nucleus

45286:AW171 hschr42629
gene id: 45286:AW171_hschr42629
uniprot id: A0A0X8HSJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAP family.
messages: nucleolus

45286:AW171 hschr2104
gene id: 45286:AW171_hschr2104
uniprot id: A0A109UVZ4
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.

45286:AW171 hschr2268
gene id: 45286:AW171_hschr2268
uniprot id: A0A120K0W3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB4 family.
messages: Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
messages: Nucleus

45286:AW171 hschr31425
gene id: 45286:AW171_hschr31425
uniprot id: A0A109UW06
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr52864
gene id: 45286:AW171_hschr52864
uniprot id: A0A109UVS5
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr255
gene id: 45286:AW171_hschr255
uniprot id: A0A125RDT6
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase. Interacts with DNA in a non-specific manner.

45286:AW171 hschr2830
gene id: 45286:AW171_hschr2830
uniprot id: A0A120K162
names: Similarity
messages: Belongs to the peptidase M16 family.

45286:AW171 hschr2900
gene id: 45286:AW171_hschr2900
uniprot id: A0A125RE08
names: Similarity
messages: Belongs to the SAICAR synthetase family.

45286:AW171 hschr31403
gene id: 45286:AW171_hschr31403
uniprot id: A0A120K1N2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiH/COQ6 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
messages: Mitochondrion inner membrane

45286:AW171 hschr74332
gene id: 45286:AW171_hschr74332
uniprot id: A0A120K2Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPR3 family.
messages: Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.
messages: Vacuole membrane

45286:AW171 hschr2421
gene id: 45286:AW171_hschr2421
uniprot id: A0A109UWL6
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.

45286:AW171 hschr31707
gene id: 45286:AW171_hschr31707
uniprot id: A0A109UYM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVP26 family.
messages: Membrane

45286:AW171 hschr31342
gene id: 45286:AW171_hschr31342
uniprot id: A0A120K1K9
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.

45286:AW171 hschr74313
gene id: 45286:AW171_hschr74313
uniprot id: A0A0X8HVL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF5 family.
messages: Nucleus

45286:AW171 hschr2995
gene id: 45286:AW171_hschr2995
uniprot id: A0A109UX54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

45286:AW171 hschr63967
gene id: 45286:AW171_hschr63967
uniprot id: A0A0X8HV47
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

45286:AW171 hschr31333
gene id: 45286:AW171_hschr31333
uniprot id: A0A109UVU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen

45286:AW171 hschr63784
gene id: 45286:AW171_hschr63784
uniprot id: A0A0X8HUL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

45286:AW171 hschr74156
gene id: 45286:AW171_hschr74156
uniprot id: A0A0X8HV84
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

45286:AW171 hschr42295
gene id: 45286:AW171_hschr42295
uniprot id: A0A109UZ92
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr84859
gene id: 45286:AW171_hschr84859
uniprot id: A0A120K2W2
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

45286:AW171 hschr42367
gene id: 45286:AW171_hschr42367
uniprot id: A0A0X8HS52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND2 (condensin subunit 2) family.
messages: Chromosome
messages: Cytoplasm
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.

45286:AW171 hschr42291
gene id: 45286:AW171_hschr42291
uniprot id: A0A0X8HS07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.

45286:AW171 hschr84509
gene id: 45286:AW171_hschr84509
uniprot id: A0A0X8HVY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Membrane

45286:AW171 hschr84540
gene id: 45286:AW171_hschr84540
uniprot id: A0A0X8HW31
names: Similarity
messages: Belongs to the glycosyltransferase 15 family.

45286:AW171 hschr31955
gene id: 45286:AW171_hschr31955
uniprot id: A0A109UYM5
names: Similarity
messages: Belongs to the Rho GDI family.

45286:AW171 hschr84640
gene id: 45286:AW171_hschr84640
uniprot id: A0A109V0D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane

45286:AW171 hschr21075
gene id: 45286:AW171_hschr21075
uniprot id: A0A109UXR0
names: Similarity
messages: Belongs to the MEMO1 family.

45286:AW171 hschr32034
gene id: 45286:AW171_hschr32034
uniprot id: A0A0X8HRL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

45286:AW171 hschr31458
gene id: 45286:AW171_hschr31458
uniprot id: A0A109UYE6
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.

45286:AW171 hschr31537
gene id: 45286:AW171_hschr31537
uniprot id: A0A109UYW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRT14 family.
messages: Involved in ribosome biogenesis, probably through modulation of rDNA transcription.
messages: nucleolus

45286:AW171 hschr63897
gene id: 45286:AW171_hschr63897
uniprot id: A0A0X8HUT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Membrane

45286:AW171 hschr84739
gene id: 45286:AW171_hschr84739
uniprot id: A0A0X8HWG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL49 family.
messages: Mitochondrion

45286:AW171 hschr74375
gene id: 45286:AW171_hschr74375
uniprot id: A0A0X8HVU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YPI1 family.
messages: Nucleus
messages: Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.

45286:AW171 hschr2906
gene id: 45286:AW171_hschr2906
uniprot id: A0A120K187
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

45286:AW171 hschr21167
gene id: 45286:AW171_hschr21167
uniprot id: A0A109UXK3
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

45286:AW171 hschr21016
gene id: 45286:AW171_hschr21016
uniprot id: A0A120K1B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr42785
gene id: 45286:AW171_hschr42785
uniprot id: A0A120K2A1
names: Similarity
messages: Belongs to the CCS1 family.

45286:AW171 hschr2201
gene id: 45286:AW171_hschr2201
uniprot id: A0A120K0T9
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

45286:AW171 hschr53363
gene id: 45286:AW171_hschr53363
uniprot id: A0A0X8HU22
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

45286:AW171 hschr2850
gene id: 45286:AW171_hschr2850
uniprot id: A0A125RE01
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.

45286:AW171 hschr74337
gene id: 45286:AW171_hschr74337
uniprot id: A0A0X8HVS8
names: Similarity
messages: Belongs to the peptidase M24B family.

45286:AW171 hschr85022
gene id: 45286:AW171_hschr85022
uniprot id: A0A109V0K5
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

45286:AW171 hschr21039
gene id: 45286:AW171_hschr21039
uniprot id: A0A109UXD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

45286:AW171 hschr53347
gene id: 45286:AW171_hschr53347
uniprot id: A0A0X8HTU5
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr21259
gene id: 45286:AW171_hschr21259
uniprot id: A0A120K1I5
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr42704
gene id: 45286:AW171_hschr42704
uniprot id: A0A0X8HSS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

45286:AW171 hschr85081
gene id: 45286:AW171_hschr85081
uniprot id: A0A0X8HWW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM10 family.
messages: Nucleus

45286:AW171 hschr53138
gene id: 45286:AW171_hschr53138
uniprot id: A0A0X8HTM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.
messages: Belongs to the NSE1 family.
messages: Component of the Smc5-Smc6 complex.
messages: Nucleus

45286:AW171 hschr42781
gene id: 45286:AW171_hschr42781
uniprot id: A0A109UZ55
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

45286:AW171 hschr53004
gene id: 45286:AW171_hschr53004
uniprot id: A0A0X8HSK3
names: Similarity
messages: Belongs to the SHQ1 family.

45286:AW171 hschr85089
gene id: 45286:AW171_hschr85089
uniprot id: A0A0X8HWW5
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

45286:AW171 hschr85010
gene id: 45286:AW171_hschr85010
uniprot id: A0A0X8HWT3
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

45286:AW171 hschr21090
gene id: 45286:AW171_hschr21090
uniprot id: A0A109UXH0
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

45286:AW171 hschr84937
gene id: 45286:AW171_hschr84937
uniprot id: A0A109V0J3
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

45286:AW171 hschr84857
gene id: 45286:AW171_hschr84857
uniprot id: A0A0X8HWH0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

45286:AW171 hschr42659
gene id: 45286:AW171_hschr42659
uniprot id: A0A109UZR9
names: Similarity
messages: Belongs to the TFIIB family.

45286:AW171 hschr2972
gene id: 45286:AW171_hschr2972
uniprot id: A0A109UX39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane

45286:AW171 hschr224
gene id: 45286:AW171_hschr224
uniprot id: A0A109UVV0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

45286:AW171 hschr31306
gene id: 45286:AW171_hschr31306
uniprot id: A0A120K1K1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.
messages: nucleolus

45286:AW171 hschr32010
gene id: 45286:AW171_hschr32010
uniprot id: A0A0X8HRJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MDM12 family.
messages: Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.
messages: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

45286:AW171 hschr42828
gene id: 45286:AW171_hschr42828
uniprot id: A0A0X8HS93
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.

45286:AW171 hschr21038
gene id: 45286:AW171_hschr21038
uniprot id: A0A109UY11
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

45286:AW171 hschr42857
gene id: 45286:AW171_hschr42857
uniprot id: A0A0X8HT08
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. PAN3 family.
messages: Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.
messages: Cytoplasm
messages: Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PAB1 (via PABC domain), conferring substrate specificity of the enzyme complex.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.
messages: The N-terminal zinc finger binds to poly(A) RNA.
messages: The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.

45286:AW171 hschr31645
gene id: 45286:AW171_hschr31645
uniprot id: A0A109UYH8
names: Similarity
messages: Belongs to the DEAD box helicase family.

45286:AW171 hschr31413
gene id: 45286:AW171_hschr31413
uniprot id: A0A120K1N6
names: Function
names: Similarity
messages: Belongs to the DPH4 family.
messages: Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

45286:AW171 hschr2869
gene id: 45286:AW171_hschr2869
uniprot id: A0A109UWZ9
names: Similarity
messages: Belongs to the AAA ATPase family.

45286:AW171 hschr63608
gene id: 45286:AW171_hschr63608
uniprot id: A0A0X8HUB4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family. PreP subfamily.
messages: Mitochondrion intermembrane space
messages: Mitochondrion matrix
messages: Monomer and homodimer; homodimerization is induced by binding of the substrate.

45286:AW171 hschr21267
gene id: 45286:AW171_hschr21267
uniprot id: A0A109UY40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr74182
gene id: 45286:AW171_hschr74182
uniprot id: A0A0X8HVB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

45286:AW171 hschr42644
gene id: 45286:AW171_hschr42644
uniprot id: A0A0X8HSK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export.
messages: Cytoplasm

45286:AW171 hschr53057
gene id: 45286:AW171_hschr53057
uniprot id: A0A0X8HTF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

45286:AW171 hschr42537
gene id: 45286:AW171_hschr42537
uniprot id: A0A0X8HSG0
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr74444
gene id: 45286:AW171_hschr74444
uniprot id: A0A109V035
names: Similarity
messages: Belongs to the PPase family.

45286:AW171 hschr2412
gene id: 45286:AW171_hschr2412
uniprot id: A0A120K105
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: Nucleus

45286:AW171 hschr21272
gene id: 45286:AW171_hschr21272
uniprot id: A0A120K1K7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SSU72 phosphatase family.
messages: Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs.
messages: Component of the cleavage and polyadenylation factor (CPF) complex.
messages: Nucleus
messages: Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).

45286:AW171 hschr63615
gene id: 45286:AW171_hschr63615
uniprot id: A0A0X8HUE5
names: Similarity
messages: Belongs to the proteasome subunit S11 family.

45286:AW171 hschr220
gene id: 45286:AW171_hschr220
uniprot id: A0A109UWN1
names: Similarity
messages: Belongs to the VPS72/YL1 family.

45286:AW171 hschr53284
gene id: 45286:AW171_hschr53284
uniprot id: A0A0X8HTQ1
names: Similarity
messages: Belongs to the NAD kinase family.

45286:AW171 hschr74145
gene id: 45286:AW171_hschr74145
uniprot id: A0A0X8HV72
names: Similarity
messages: Belongs to the TSR2 family.

45286:AW171 hschr32036
gene id: 45286:AW171_hschr32036
uniprot id: A0A0X8HRK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: spindle

45286:AW171 hschr2294
gene id: 45286:AW171_hschr2294
uniprot id: A0A109UWT9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

45286:AW171 hschr53191
gene id: 45286:AW171_hschr53191
uniprot id: A0A109UXF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

45286:AW171 hschr53360
gene id: 45286:AW171_hschr53360
uniprot id: A0A0X8HU17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.
messages: Vacuole membrane

45286:AW171 hschr84770
gene id: 45286:AW171_hschr84770
uniprot id: A0A0X8HWI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM41 family.
messages: Mitochondrion

45286:AW171 hschr63544
gene id: 45286:AW171_hschr63544
uniprot id: A0A120K2H9
names: Subcellular Location Annotation
messages: cytosol

45286:AW171 hschr21110
gene id: 45286:AW171_hschr21110
uniprot id: A0A109UXT6
names: Similarity
messages: Belongs to the SDHAF4 family.

45286:AW171 hschr74350
gene id: 45286:AW171_hschr74350
uniprot id: A0A109UY61
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome.
messages: Nucleus
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends.

45286:AW171 hschr74105
gene id: 45286:AW171_hschr74105
uniprot id: A0A120K2N5
names: Similarity
messages: Belongs to the peptidase M28 family. M28B subfamily.

45286:AW171 hschr74358
gene id: 45286:AW171_hschr74358
uniprot id: A0A0X8HVN7
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr84557
gene id: 45286:AW171_hschr84557
uniprot id: A0A0X8HW37
names: Similarity
messages: Belongs to the PIAS family.

45286:AW171 hschr32052
gene id: 45286:AW171_hschr32052
uniprot id: A0A0X8HRK6
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.

45286:AW171 hschr2443
gene id: 45286:AW171_hschr2443
uniprot id: A0A120K131
names: Similarity
messages: Belongs to the CENP-C/MIF2 family.

45286:AW171 hschr2986
gene id: 45286:AW171_hschr2986
uniprot id: A0A120K1A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck

45286:AW171 hschr240
gene id: 45286:AW171_hschr240
uniprot id: A0A109UVV9
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr31728
gene id: 45286:AW171_hschr31728
uniprot id: A0A109UYI1
names: Similarity
messages: Belongs to the PPP phosphatase family.

45286:AW171 hschr52895
gene id: 45286:AW171_hschr52895
uniprot id: A0A0X8HSD2
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

45286:AW171 hschr74003
gene id: 45286:AW171_hschr74003
uniprot id: A0A0X8HV16
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr53421
gene id: 45286:AW171_hschr53421
uniprot id: A0A0X8HU53
names: Function
names: Similarity
messages: Belongs to the CTR86 family.
messages: Essential protein which may be involved in threonine biosynthesis.

45286:AW171 hschr42114
gene id: 45286:AW171_hschr42114
uniprot id: A0A0X8HRQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNU66/SART1 family.
messages: Nucleus

45286:AW171 hschr53305
gene id: 45286:AW171_hschr53305
uniprot id: A0A0X8HTU7
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

45286:AW171 hschr74104
gene id: 45286:AW171_hschr74104
uniprot id: A0A0X8HV55
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

45286:AW171 hschr74439
gene id: 45286:AW171_hschr74439
uniprot id: A0A0X8HVX8
names: Similarity
messages: Belongs to the SAP30 family.

45286:AW171 hschr42666
gene id: 45286:AW171_hschr42666
uniprot id: A0A0X8HSR5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

45286:AW171 hschr84830
gene id: 45286:AW171_hschr84830
uniprot id: A0A109UYK7
names: Subunit
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

45286:AW171 hschr42260
gene id: 45286:AW171_hschr42260
uniprot id: A0A120K242
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
messages: Membrane

45286:AW171 hschr84740
gene id: 45286:AW171_hschr84740
uniprot id: A0A0X8HWF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr52901
gene id: 45286:AW171_hschr52901
uniprot id: A0A109UX91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGM101 family.
messages: mitochondrion nucleoid

45286:AW171 hschr31525
gene id: 45286:AW171_hschr31525
uniprot id: A0A109UW63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

45286:AW171 hschr31309
gene id: 45286:AW171_hschr31309
uniprot id: A0A109UXQ9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

45286:AW171 hschr84901
gene id: 45286:AW171_hschr84901
uniprot id: A0A0X8HWN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr2342
gene id: 45286:AW171_hschr2342
uniprot id: A0A109UWE9
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr21145
gene id: 45286:AW171_hschr21145
uniprot id: A0A120K1F1
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr42430
gene id: 45286:AW171_hschr42430
uniprot id: A0A109UYY1
names: Similarity
messages: Belongs to the glycosyl hydrolase 15 family.

45286:AW171 hschr42428
gene id: 45286:AW171_hschr42428
uniprot id: A0A109UZ47
names: Similarity
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Octamer of two non-identical subunits IDH1 and IDH2.

45286:AW171 hschr84694
gene id: 45286:AW171_hschr84694
uniprot id: A0A0X8HWE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM11 family.
messages: Membrane

45286:AW171 hschr53101
gene id: 45286:AW171_hschr53101
uniprot id: A0A109UZQ6
names: Similarity
messages: Belongs to the NAD kinase family.

45286:AW171 hschr2277
gene id: 45286:AW171_hschr2277
uniprot id: A0A109UWB2
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.

45286:AW171 hschr63630
gene id: 45286:AW171_hschr63630
uniprot id: A0A109V018
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

45286:AW171 hschr31914
gene id: 45286:AW171_hschr31914
uniprot id: A0A0X8HRC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr21117
gene id: 45286:AW171_hschr21117
uniprot id: A0A120K1D9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

45286:AW171 hschr84667
gene id: 45286:AW171_hschr84667
uniprot id: A0A0X8HW90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr53009
gene id: 45286:AW171_hschr53009
uniprot id: A0A109UXC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum.

45286:AW171 hschr31672
gene id: 45286:AW171_hschr31672
uniprot id: A0A120K1W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex DUO1 family.
messages: Nucleus
messages: kinetochore

45286:AW171 hschr42433
gene id: 45286:AW171_hschr42433
uniprot id: A0A109UZB7
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.

45286:AW171 hschr84856
gene id: 45286:AW171_hschr84856
uniprot id: A0A109V0G1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr2440
gene id: 45286:AW171_hschr2440
uniprot id: A0A109UWM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

45286:AW171 hschr42729
gene id: 45286:AW171_hschr42729
uniprot id: A0A0X8HSQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 8 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

45286:AW171 hschr2112
gene id: 45286:AW171_hschr2112
uniprot id: A0A120K0R2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Membrane
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.

45286:AW171 hschr74067
gene id: 45286:AW171_hschr74067
uniprot id: A0A0X8HVA6
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.

45286:AW171 hschr84577
gene id: 45286:AW171_hschr84577
uniprot id: A0A109V094
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.

45286:AW171 hschr31664
gene id: 45286:AW171_hschr31664
uniprot id: A0A109UYE2
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

45286:AW171 hschr31628
gene id: 45286:AW171_hschr31628
uniprot id: A0A109UZ24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
messages: nucleolus

45286:AW171 hschr42573
gene id: 45286:AW171_hschr42573
uniprot id: A0A109UZ07
names: Similarity
messages: Belongs to the peptidase A1 family.

45286:AW171 hschr84838
gene id: 45286:AW171_hschr84838
uniprot id: A0A0X8HWI9
names: Similarity
messages: Belongs to the DEAD box helicase family.

45286:AW171 hschr74009
gene id: 45286:AW171_hschr74009
uniprot id: A0A120K2M5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

45286:AW171 hschr32018
gene id: 45286:AW171_hschr32018
uniprot id: A0A120K218
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr53133
gene id: 45286:AW171_hschr53133
uniprot id: A0A109V020
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTF2H2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.
messages: Nucleus

45286:AW171 hschr74147
gene id: 45286:AW171_hschr74147
uniprot id: A0A0X8HVE2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

45286:AW171 hschr31911
gene id: 45286:AW171_hschr31911
uniprot id: A0A109UWM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

45286:AW171 hschr2831
gene id: 45286:AW171_hschr2831
uniprot id: A0A120K154
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CybS family.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr74077
gene id: 45286:AW171_hschr74077
uniprot id: A0A109UZZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

45286:AW171 hschr74344
gene id: 45286:AW171_hschr74344
uniprot id: A0A0X8HVN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Nucleus

45286:AW171 hschr2997
gene id: 45286:AW171_hschr2997
uniprot id: A0A109UXL1
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

45286:AW171 hschr53216
gene id: 45286:AW171_hschr53216
uniprot id: A0A0X8HTS9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

45286:AW171 hschr42487
gene id: 45286:AW171_hschr42487
uniprot id: A0A0X8HSH8
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).

45286:AW171 hschr31623
gene id: 45286:AW171_hschr31623
uniprot id: A0A120K1V5
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr42323
gene id: 45286:AW171_hschr42323
uniprot id: A0A120K251
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

45286:AW171 hschr31868
gene id: 45286:AW171_hschr31868
uniprot id: A0A0X8HRB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

45286:AW171 hschr63665
gene id: 45286:AW171_hschr63665
uniprot id: A0A0X8HUG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPP2 family.
messages: Involved in spliceosome maturation and the first step of pre-mRNA splicing.
messages: Nucleus

45286:AW171 hschr31409
gene id: 45286:AW171_hschr31409
uniprot id: A0A109UXT0
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr84866
gene id: 45286:AW171_hschr84866
uniprot id: A0A0X8HWH7
names: Cofactor
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.

45286:AW171 hschr74402
gene id: 45286:AW171_hschr74402
uniprot id: A0A109V0S6
names: Similarity
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Homodimer.

45286:AW171 hschr84753
gene id: 45286:AW171_hschr84753
uniprot id: A0A0X8HWB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IMPACT family.
messages: Cytoplasm

45286:AW171 hschr63958
gene id: 45286:AW171_hschr63958
uniprot id: A0A0X8HUW0
names: Similarity
messages: Belongs to the peptidase S10 family.

45286:AW171 hschr63511
gene id: 45286:AW171_hschr63511
uniprot id: A0A120K2H7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NST1 family.
messages: Cytoplasm
messages: May act as a negative regulator of salt tolerance.

45286:AW171 hschr42408
gene id: 45286:AW171_hschr42408
uniprot id: A0A0X8HS81
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

45286:AW171 hschr42813
gene id: 45286:AW171_hschr42813
uniprot id: A0A0X8HSZ4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
messages: Heterodimer of an alpha and a beta chain.
messages: Mitochondrion matrix
messages: The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion.

45286:AW171 hschr31384
gene id: 45286:AW171_hschr31384
uniprot id: A0A120K1N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

45286:AW171 hschr63599
gene id: 45286:AW171_hschr63599
uniprot id: A0A0X8HUD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPI19 family.
messages: Component of the phosphatidylinositol N-acetylglucosaminyltransferase (GPI-GlcNAc transferase) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

45286:AW171 hschr85053
gene id: 45286:AW171_hschr85053
uniprot id: A0A120K2Y5
names: Similarity
messages: Belongs to the putative lipase ROG1 family.

45286:AW171 hschr84643
gene id: 45286:AW171_hschr84643
uniprot id: A0A0X8HW50
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr74238
gene id: 45286:AW171_hschr74238
uniprot id: A0A0X8HVD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

45286:AW171 hschr63773
gene id: 45286:AW171_hschr63773
uniprot id: A0A0X8HUM6
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

45286:AW171 hschr52992
gene id: 45286:AW171_hschr52992
uniprot id: A0A0X8HT91
names: Similarity
names: Subunit
messages: Belongs to the pyruvate kinase family.
messages: Homotetramer.

45286:AW171 hschr42493
gene id: 45286:AW171_hschr42493
uniprot id: A0A0X8HSC9
names: Similarity
messages: Belongs to the cytochrome P450 family.

45286:AW171 hschr63637
gene id: 45286:AW171_hschr63637
uniprot id: A0A0X8HUJ0
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.

45286:AW171 hschr2854
gene id: 45286:AW171_hschr2854
uniprot id: A0A125RE02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP53 family.
messages: May play a role in ribosome biogenesis.
messages: nucleolus
messages: nucleoplasm

45286:AW171 hschr74327
gene id: 45286:AW171_hschr74327
uniprot id: A0A0X8HVL7
names: Similarity
messages: Belongs to the AAA ATPase family.

45286:AW171 hschr31427
gene id: 45286:AW171_hschr31427
uniprot id: A0A109UYD1
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

45286:AW171 hschr42797
gene id: 45286:AW171_hschr42797
uniprot id: A0A109UZ26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat BOP1/ERB1 family.
messages: Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.
messages: Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

45286:AW171 hschr2315
gene id: 45286:AW171_hschr2315
uniprot id: A0A109UWD8
names: Similarity
messages: Belongs to the CCZ1 family.

45286:AW171 hschr31324
gene id: 45286:AW171_hschr31324
uniprot id: A0A120K1M1
names: Similarity
messages: Belongs to the RPAP1 family.

45286:AW171 hschr63529
gene id: 45286:AW171_hschr63529
uniprot id: A0A109UZK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PSMG2 family.
messages: Component of the 20S proteasome chaperone.
messages: Involved in 20S proteasome assembly.

45286:AW171 hschr74261
gene id: 45286:AW171_hschr74261
uniprot id: A0A0X8HVE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Golgi apparatus membrane
messages: Golgi membrane protein involved in vesicular trafficking.
messages: Membrane

45286:AW171 hschr63767
gene id: 45286:AW171_hschr63767
uniprot id: A0A109UZZ2
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

45286:AW171 hschr31700
gene id: 45286:AW171_hschr31700
uniprot id: A0A120K1Y1
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr32008
gene id: 45286:AW171_hschr32008
uniprot id: A0A0X8HRI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: nucleolus

45286:AW171 hschr52932
gene id: 45286:AW171_hschr52932
uniprot id: A0A120K2B2
names: Similarity
messages: Belongs to the XPG/RAD2 endonuclease family.

45286:AW171 hschr63617
gene id: 45286:AW171_hschr63617
uniprot id: A0A0X8HUI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
messages: Belongs to the dynein light chain family.
messages: Cytoplasmic dynein consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).
messages: cytoskeleton
messages: nuclear pore complex

45286:AW171 hschr74417
gene id: 45286:AW171_hschr74417
uniprot id: A0A109V069
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

45286:AW171 hschr2480
gene id: 45286:AW171_hschr2480
uniprot id: A0A125RDY9
names: Similarity
messages: Belongs to the REXO1/REXO3 family.

45286:AW171 hschr31445
gene id: 45286:AW171_hschr31445
uniprot id: A0A120K1P3
names: Subcellular Location Annotation
messages: Mitochondrion

45286:AW171 hschr2327
gene id: 45286:AW171_hschr2327
uniprot id: A0A109UWW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

45286:AW171 hschr31450
gene id: 45286:AW171_hschr31450
uniprot id: A0A109UY25
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

45286:AW171 hschr52925
gene id: 45286:AW171_hschr52925
uniprot id: A0A0X8HT51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLE1 family.
messages: nuclear pore complex

45286:AW171 hschr2381
gene id: 45286:AW171_hschr2381
uniprot id: A0A120K0Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLD2 family.
messages: Has a role in the initiation of DNA replication. Required at S-phase checkpoint.
messages: Nucleus

45286:AW171 hschr42743
gene id: 45286:AW171_hschr42743
uniprot id: A0A0X8HSW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Membrane

45286:AW171 hschr42700
gene id: 45286:AW171_hschr42700
uniprot id: A0A0X8HSV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.

45286:AW171 hschr42083
gene id: 45286:AW171_hschr42083
uniprot id: A0A0X8HRN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS3 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr52954
gene id: 45286:AW171_hschr52954
uniprot id: A0A0X8HT74
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.
messages: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

45286:AW171 hschr31670
gene id: 45286:AW171_hschr31670
uniprot id: A0A120K1X1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 31 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

45286:AW171 hschr84839
gene id: 45286:AW171_hschr84839
uniprot id: A0A0X8HW25
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr42160
gene id: 45286:AW171_hschr42160
uniprot id: A0A0X8HRS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWC4 family.
messages: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
messages: Nucleus

45286:AW171 hschr2238
gene id: 45286:AW171_hschr2238
uniprot id: A0A120K0V3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Monomer.

45286:AW171 hschr31777
gene id: 45286:AW171_hschr31777
uniprot id: A0A0X8HR50
names: Similarity
messages: Belongs to the VAC14 family.

45286:AW171 hschr84510
gene id: 45286:AW171_hschr84510
uniprot id: A0A109V0F1
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

45286:AW171 hschr21183
gene id: 45286:AW171_hschr21183
uniprot id: A0A109UXL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIM16/PAM16 family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation.
messages: Mitochondrion inner membrane

45286:AW171 hschr21241
gene id: 45286:AW171_hschr21241
uniprot id: A0A120K1J4
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

45286:AW171 hschr84511
gene id: 45286:AW171_hschr84511
uniprot id: A0A0X8HVV4
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr84597
gene id: 45286:AW171_hschr84597
uniprot id: A0A109V0W5
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

45286:AW171 hschr21222
gene id: 45286:AW171_hschr21222
uniprot id: A0A120K1H6
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr256
gene id: 45286:AW171_hschr256
uniprot id: A0A109UVW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

45286:AW171 hschr74131
gene id: 45286:AW171_hschr74131
uniprot id: A0A0X8HVE0
names: Similarity
messages: Belongs to the MNN1/MNT family.

45286:AW171 hschr63970
gene id: 45286:AW171_hschr63970
uniprot id: A0A0X8HUE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF4 family.
messages: Membrane

45286:AW171 hschr250
gene id: 45286:AW171_hschr250
uniprot id: A0A109UVZ5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

45286:AW171 hschr74326
gene id: 45286:AW171_hschr74326
uniprot id: A0A0X8HVP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 28 family.
messages: Endoplasmic reticulum
messages: Heterodimer with ALG14 to form a functional enzyme.
messages: Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.

45286:AW171 hschr32048
gene id: 45286:AW171_hschr32048
uniprot id: A0A0X8HRL9
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr31746
gene id: 45286:AW171_hschr31746
uniprot id: A0A0X8HR29
names: Similarity
messages: Belongs to the RNR ribonuclease family.

45286:AW171 hschr53392
gene id: 45286:AW171_hschr53392
uniprot id: A0A0X8HU16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS27 family.
messages: Endosome membrane
messages: Membrane

45286:AW171 hschr21243
gene id: 45286:AW171_hschr21243
uniprot id: A0A109UXL8
names: Similarity
messages: Belongs to the universal ribosomal protein uS3 family.

45286:AW171 hschr31454
gene id: 45286:AW171_hschr31454
uniprot id: A0A109UY33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFR1/MEI5 family.
messages: Nucleus

45286:AW171 hschr2992
gene id: 45286:AW171_hschr2992
uniprot id: A0A109UXB0
names: Function
names: Similarity
messages: Belongs to the EAF1 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.

45286:AW171 hschr31677
gene id: 45286:AW171_hschr31677
uniprot id: A0A109UYE7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

45286:AW171 hschr53466
gene id: 45286:AW171_hschr53466
uniprot id: A0A0X8HU60
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr31298
gene id: 45286:AW171_hschr31298
uniprot id: A0A109UZD5
names: Similarity
messages: Belongs to the SUI1 family.

45286:AW171 hschr31620
gene id: 45286:AW171_hschr31620
uniprot id: A0A120K1U8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPI1/TEX10 family.
messages: Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.
messages: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.
messages: Nucleus

45286:AW171 hschr2865
gene id: 45286:AW171_hschr2865
uniprot id: A0A109UX07
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr53433
gene id: 45286:AW171_hschr53433
uniprot id: A0A109UXL2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

45286:AW171 hschr63611
gene id: 45286:AW171_hschr63611
uniprot id: A0A109UXP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT5 family.
messages: Nucleus
messages: The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.

45286:AW171 hschr32001
gene id: 45286:AW171_hschr32001
uniprot id: A0A109UYN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG22 family.
messages: Membrane
messages: Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.
messages: Vacuole membrane

45286:AW171 hschr53379
gene id: 45286:AW171_hschr53379
uniprot id: A0A0X8HU09
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

45286:AW171 hschr42206
gene id: 45286:AW171_hschr42206
uniprot id: A0A0X8HRX1
names: Similarity
messages: Belongs to the DNA polymerase type-B-like family.

45286:AW171 hschr2178
gene id: 45286:AW171_hschr2178
uniprot id: A0A125RDV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 3-HAO family.
messages: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
messages: Cytoplasm

45286:AW171 hschr31369
gene id: 45286:AW171_hschr31369
uniprot id: A0A120K1N4
names: Similarity
messages: Belongs to the AB hydrolase superfamily. MetX family.

45286:AW171 hschr84671
gene id: 45286:AW171_hschr84671
uniprot id: A0A120K2U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRG family.
messages: Nucleus

45286:AW171 hschr63806
gene id: 45286:AW171_hschr63806
uniprot id: A0A0X8HUP3
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

45286:AW171 hschr2287
gene id: 45286:AW171_hschr2287
uniprot id: A0A109UWE5
names: Similarity
messages: Belongs to the Nudix hydrolase family.

45286:AW171 hschr21005
gene id: 45286:AW171_hschr21005
uniprot id: A0A109UX97
names: Similarity
messages: Belongs to the RMD1/sif2 family.

45286:AW171 hschr42250
gene id: 45286:AW171_hschr42250
uniprot id: A0A0X8HRZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP2 family.
messages: nucleolus

45286:AW171 hschr84595
gene id: 45286:AW171_hschr84595
uniprot id: A0A109V0B0
names: Similarity
messages: Belongs to the PAT1 family.

45286:AW171 hschr63895
gene id: 45286:AW171_hschr63895
uniprot id: A0A0X8HUU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Nucleus

45286:AW171 hschr63973
gene id: 45286:AW171_hschr63973
uniprot id: A0A0X8HUX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 17 family.
messages: cell wall

45286:AW171 hschr42177
gene id: 45286:AW171_hschr42177
uniprot id: A0A0X8HQU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku70 family.
messages: Nucleus
messages: telomere

45286:AW171 hschr84693
gene id: 45286:AW171_hschr84693
uniprot id: A0A0X8HW66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion inner membrane
messages: Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.

45286:AW171 hschr298
gene id: 45286:AW171_hschr298
uniprot id: A0A109UW26
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: cytoskeleton

45286:AW171 hschr42420
gene id: 45286:AW171_hschr42420
uniprot id: A0A0X8HSB3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

45286:AW171 hschr74415
gene id: 45286:AW171_hschr74415
uniprot id: A0A109V039
names: Similarity
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Homodimer.

45286:AW171 hschr74134
gene id: 45286:AW171_hschr74134
uniprot id: A0A0X8HUR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

45286:AW171 hschr84821
gene id: 45286:AW171_hschr84821
uniprot id: A0A0X8HWI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

45286:AW171 hschr53105
gene id: 45286:AW171_hschr53105
uniprot id: A0A0X8HTE0
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr31529
gene id: 45286:AW171_hschr31529
uniprot id: A0A120K1S1
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr53300
gene id: 45286:AW171_hschr53300
uniprot id: A0A0X8HTR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KXD1 family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.
messages: Endosome

45286:AW171 hschr63528
gene id: 45286:AW171_hschr63528
uniprot id: A0A0X8HU67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II.
messages: Cytoplasm
messages: Nucleus
messages: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.

45286:AW171 hschr42463
gene id: 45286:AW171_hschr42463
uniprot id: A0A109UZN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes.
messages: Nucleus

45286:AW171 hschr2499
gene id: 45286:AW171_hschr2499
uniprot id: A0A109UWT6
names: Function
messages: Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.

45286:AW171 hschr21170
gene id: 45286:AW171_hschr21170
uniprot id: A0A109UXM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr74272
gene id: 45286:AW171_hschr74272
uniprot id: A0A109V040
names: Similarity
messages: Belongs to the XPC family.

45286:AW171 hschr74066
gene id: 45286:AW171_hschr74066
uniprot id: A0A0X8HV24
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

45286:AW171 hschr32005
gene id: 45286:AW171_hschr32005
uniprot id: A0A0X8HRJ1
names: Similarity
messages: Belongs to the OPA3 family.

45286:AW171 hschr84766
gene id: 45286:AW171_hschr84766
uniprot id: A0A0X8HWC9
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

45286:AW171 hschr21289
gene id: 45286:AW171_hschr21289
uniprot id: A0A109UXQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG2 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Preautophagosomal structure membrane

45286:AW171 hschr42677
gene id: 45286:AW171_hschr42677
uniprot id: A0A109UZG5
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.

45286:AW171 hschr31942
gene id: 45286:AW171_hschr31942
uniprot id: A0A109UWP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-14 family.
messages: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
messages: Peroxisome membrane

45286:AW171 hschr42184
gene id: 45286:AW171_hschr42184
uniprot id: A0A109UZH2
names: Similarity
messages: Belongs to the PTH family.

45286:AW171 hschr42143
gene id: 45286:AW171_hschr42143
uniprot id: A0A0X8HRU9
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr63782
gene id: 45286:AW171_hschr63782
uniprot id: A0A0X8HUQ4
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr42089
gene id: 45286:AW171_hschr42089
uniprot id: A0A109UYS4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

45286:AW171 hschr42706
gene id: 45286:AW171_hschr42706
uniprot id: A0A0X8HSR3
names: Similarity
messages: Belongs to the glycosyltransferase 15 family.

45286:AW171 hschr74219
gene id: 45286:AW171_hschr74219
uniprot id: A0A0X8HVE5
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr42762
gene id: 45286:AW171_hschr42762
uniprot id: A0A0X8HSX2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

45286:AW171 hschr42405
gene id: 45286:AW171_hschr42405
uniprot id: A0A109UYC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

45286:AW171 hschr31816
gene id: 45286:AW171_hschr31816
uniprot id: A0A109UWK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the fungal fatty acid synthetase subunit beta family.
messages: Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.
messages: [Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).

45286:AW171 hschr42234
gene id: 45286:AW171_hschr42234
uniprot id: A0A0X8HRY3
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

45286:AW171 hschr2298
gene id: 45286:AW171_hschr2298
uniprot id: A0A120K0Y2
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

45286:AW171 hschr42599
gene id: 45286:AW171_hschr42599
uniprot id: A0A0X8HSM2
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr63964
gene id: 45286:AW171_hschr63964
uniprot id: A0A0X8HV53
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

45286:AW171 hschr31722
gene id: 45286:AW171_hschr31722
uniprot id: A0A109UWI9
names: Similarity
messages: Belongs to the ZNF598/HEL2 family.

45286:AW171 hschr84562
gene id: 45286:AW171_hschr84562
uniprot id: A0A0X8HVX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.
messages: Nucleus

45286:AW171 hschr74231
gene id: 45286:AW171_hschr74231
uniprot id: A0A0X8HVC0
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

45286:AW171 hschr2507
gene id: 45286:AW171_hschr2507
uniprot id: A0A120K147
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBP/SF1 family.
messages: Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
messages: Nucleus

45286:AW171 hschr42576
gene id: 45286:AW171_hschr42576
uniprot id: A0A109UZE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cut8/STS1 family.
messages: Binds the proteasome.
messages: Cytoplasm
messages: Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.
messages: Nucleus

45286:AW171 hschr2135
gene id: 45286:AW171_hschr2135
uniprot id: A0A109UW18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDA11 family.
messages: Cytoplasm

45286:AW171 hschr21274
gene id: 45286:AW171_hschr21274
uniprot id: A0A109UXN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SQS1 family.
messages: Cytoplasm
messages: Nucleus

45286:AW171 hschr2340
gene id: 45286:AW171_hschr2340
uniprot id: A0A109UWI6
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.

45286:AW171 hschr53343
gene id: 45286:AW171_hschr53343
uniprot id: A0A109UZV2
names: Similarity
messages: Belongs to the SELO family.

45286:AW171 hschr63577
gene id: 45286:AW171_hschr63577
uniprot id: A0A0X8HU98
names: Similarity
messages: Belongs to the guanylate kinase family.

45286:AW171 hschr74453
gene id: 45286:AW171_hschr74453
uniprot id: A0A0X8HVR3
names: Similarity
messages: Belongs to the SUN family.

45286:AW171 hschr74483
gene id: 45286:AW171_hschr74483
uniprot id: A0A0X8HVU8
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.

45286:AW171 hschr42688
gene id: 45286:AW171_hschr42688
uniprot id: A0A0X8HSR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr2535
gene id: 45286:AW171_hschr2535
uniprot id: A0A120K143
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Component of the exocyst complex.

45286:AW171 hschr74171
gene id: 45286:AW171_hschr74171
uniprot id: A0A0X8HUT8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

45286:AW171 hschr63645
gene id: 45286:AW171_hschr63645
uniprot id: A0A120K2J3
names: Similarity
messages: Belongs to the VPS29 family.

45286:AW171 hschr53080
gene id: 45286:AW171_hschr53080
uniprot id: A0A0X8HTG3
names: Similarity
messages: Belongs to the APC5 family.

45286:AW171 hschr74215
gene id: 45286:AW171_hschr74215
uniprot id: A0A0X8HVB9
names: Function
names: Similarity
messages: Belongs to the peptidase M24 family.
messages: Probable metalloprotease involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm.

45286:AW171 hschr63689
gene id: 45286:AW171_hschr63689
uniprot id: A0A0X8HUH6
names: Similarity
messages: Belongs to the ATG16 family.

45286:AW171 hschr63546
gene id: 45286:AW171_hschr63546
uniprot id: A0A120K2I1
names: Similarity
messages: Belongs to the thymidylate kinase family.

45286:AW171 hschr74354
gene id: 45286:AW171_hschr74354
uniprot id: A0A0X8HVL5
names: Similarity
messages: Belongs to the RRP12 family.

45286:AW171 hschr53423
gene id: 45286:AW171_hschr53423
uniprot id: A0A0X8HTY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: nucleolus

45286:AW171 hschr31679
gene id: 45286:AW171_hschr31679
uniprot id: A0A109UYF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDS23 family.
messages: Cytoplasm
messages: Involved in DNA replication and cell separation.

45286:AW171 hschr84898
gene id: 45286:AW171_hschr84898
uniprot id: A0A0X8HWQ0
names: Similarity
messages: Belongs to the universal ribosomal protein uS13 family.

45286:AW171 hschr63768
gene id: 45286:AW171_hschr63768
uniprot id: A0A0X8HUK6
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

45286:AW171 hschr84726
gene id: 45286:AW171_hschr84726
uniprot id: A0A0X8HWB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr31440
gene id: 45286:AW171_hschr31440
uniprot id: A0A109UW15
names: Similarity
messages: Belongs to the peroxin-13 family.

45286:AW171 hschr31818
gene id: 45286:AW171_hschr31818
uniprot id: A0A109UYY5
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

45286:AW171 hschr84900
gene id: 45286:AW171_hschr84900
uniprot id: A0A0X8HW72
names: Similarity
messages: Belongs to the MAD2 family.

45286:AW171 hschr84641
gene id: 45286:AW171_hschr84641
uniprot id: A0A109UYG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

45286:AW171 hschr31417
gene id: 45286:AW171_hschr31417
uniprot id: A0A109UXX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL46 family.
messages: Mitochondrion

45286:AW171 hschr53173
gene id: 45286:AW171_hschr53173
uniprot id: A0A109UZB2
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

45286:AW171 hschr42079
gene id: 45286:AW171_hschr42079
uniprot id: A0A0X8HRP6
names: Similarity
messages: Belongs to the multicopper oxidase family.

45286:AW171 hschr31709
gene id: 45286:AW171_hschr31709
uniprot id: A0A109UWH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

45286:AW171 hschr74389
gene id: 45286:AW171_hschr74389
uniprot id: A0A0X8HVW0
names: Similarity
messages: Belongs to the PITHD1 family.

45286:AW171 hschr42153
gene id: 45286:AW171_hschr42153
uniprot id: A0A109UZ56
names: Similarity
messages: Belongs to the cytidylyltransferase family.

45286:AW171 hschr42222
gene id: 45286:AW171_hschr42222
uniprot id: A0A0X8HRY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

45286:AW171 hschr21035
gene id: 45286:AW171_hschr21035
uniprot id: A0A120K1B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGF family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr84852
gene id: 45286:AW171_hschr84852
uniprot id: A0A0X8HWM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF alpha subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.

45286:AW171 hschr42792
gene id: 45286:AW171_hschr42792
uniprot id: A0A0X8HSY9
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr74435
gene id: 45286:AW171_hschr74435
uniprot id: A0A0X8HVS2
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr84537
gene id: 45286:AW171_hschr84537
uniprot id: A0A0X8HVY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr74434
gene id: 45286:AW171_hschr74434
uniprot id: A0A120K2R7
names: Similarity
messages: Belongs to the THADA family.

45286:AW171 hschr63670
gene id: 45286:AW171_hschr63670
uniprot id: A0A0X8HTT4
names: Similarity
messages: Belongs to the thiamine pyrophosphokinase family.

45286:AW171 hschr21103
gene id: 45286:AW171_hschr21103
uniprot id: A0A109UVA6
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

45286:AW171 hschr31646
gene id: 45286:AW171_hschr31646
uniprot id: A0A109UYD2
names: Similarity
messages: Belongs to the RRM CWC2 family.

45286:AW171 hschr2199
gene id: 45286:AW171_hschr2199
uniprot id: A0A109UWM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

45286:AW171 hschr42370
gene id: 45286:AW171_hschr42370
uniprot id: A0A109UWX7
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

45286:AW171 hschr31779
gene id: 45286:AW171_hschr31779
uniprot id: A0A0X8HR52
names: Subcellular Location Annotation
messages: nucleolus

45286:AW171 hschr32045
gene id: 45286:AW171_hschr32045
uniprot id: A0A0X8HRK2
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.

45286:AW171 hschr53330
gene id: 45286:AW171_hschr53330
uniprot id: A0A0X8HU02
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

45286:AW171 hschr31565
gene id: 45286:AW171_hschr31565
uniprot id: A0A109UY92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTU2/NCS2 family.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.

45286:AW171 hschr31885
gene id: 45286:AW171_hschr31885
uniprot id: A0A0X8HRB3
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

45286:AW171 hschr84761
gene id: 45286:AW171_hschr84761
uniprot id: A0A0X8HWB0
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr31354
gene id: 45286:AW171_hschr31354
uniprot id: A0A120K1M8
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.

45286:AW171 hschr84775
gene id: 45286:AW171_hschr84775
uniprot id: A0A109V0B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

45286:AW171 hschr74269
gene id: 45286:AW171_hschr74269
uniprot id: A0A0X8HVF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SLU7 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

45286:AW171 hschr42671
gene id: 45286:AW171_hschr42671
uniprot id: A0A0X8HSN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAN1 family.
messages: Cell membrane
messages: Endosome membrane
messages: Membrane
messages: actin patch

45286:AW171 hschr2252
gene id: 45286:AW171_hschr2252
uniprot id: A0A120K0W6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG11 family.
messages: Homodimer.
messages: Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.
messages: Membrane
messages: Preautophagosomal structure membrane
messages: Vacuole membrane

45286:AW171 hschr74245
gene id: 45286:AW171_hschr74245
uniprot id: A0A0X8HVE3
names: Similarity
messages: Belongs to the PPP phosphatase family.

45286:AW171 hschr31305
gene id: 45286:AW171_hschr31305
uniprot id: A0A120K1K0
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr21006
gene id: 45286:AW171_hschr21006
uniprot id: A0A125RE21
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADPH--cytochrome P450 reductase family.
messages: Binds 1 FAD per monomer.
messages: Binds 1 FMN per monomer.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion outer membrane
messages: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.

45286:AW171 hschr31989
gene id: 45286:AW171_hschr31989
uniprot id: A0A109UZD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr42411
gene id: 45286:AW171_hschr42411
uniprot id: A0A109UYT8
names: Similarity
messages: Belongs to the cyclin family.

45286:AW171 hschr21032
gene id: 45286:AW171_hschr21032
uniprot id: A0A120K1C7
names: Similarity
messages: Belongs to the PIH1 family.

45286:AW171 hschr53193
gene id: 45286:AW171_hschr53193
uniprot id: A0A109UZS6
names: Similarity
messages: Belongs to the complex I LYR family. SDHAF1 subfamily.

45286:AW171 hschr74278
gene id: 45286:AW171_hschr74278
uniprot id: A0A0X8HVM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

45286:AW171 hschr31497
gene id: 45286:AW171_hschr31497
uniprot id: A0A109UW50
names: Similarity
messages: Belongs to the glycosyl hydrolase 76 family.

45286:AW171 hschr21068
gene id: 45286:AW171_hschr21068
uniprot id: A0A109UXE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVF1 family.
messages: Cytoplasm

45286:AW171 hschr42359
gene id: 45286:AW171_hschr42359
uniprot id: A0A0X8HS62
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

45286:AW171 hschr63756
gene id: 45286:AW171_hschr63756
uniprot id: A0A109V0E5
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr2301
gene id: 45286:AW171_hschr2301
uniprot id: A0A120K0X2
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

45286:AW171 hschr42622
gene id: 45286:AW171_hschr42622
uniprot id: A0A109UZ18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Peroxisome membrane

45286:AW171 hschr31785
gene id: 45286:AW171_hschr31785
uniprot id: A0A120K1Z6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

45286:AW171 hschr2200
gene id: 45286:AW171_hschr2200
uniprot id: A0A109UW77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5' to 3' DNA replicative helicase recruited to paused replisomes to promote fork progression throughout nonhistone protein-DNA complexes, naturally occurring impediments that are encountered in each S phase where replication forks pauses. Required for timely replication of the telomere and subtelomeric DNA and for wild-type levels of telomeric silencing. Involved in DNA repair during stalled replication fork, regulation of fragile sites expression and essential for genome stability. Plays also a role in mtDNA replication. Has G-quadruplex (G4) unwinding activity and can suppress G4-induced genome instability when PIF1 levels are low.
messages: Belongs to the helicase family. PIF1 subfamily.
messages: Nucleus
messages: telomere

45286:AW171 hschr2527
gene id: 45286:AW171_hschr2527
uniprot id: A0A125RDZ5
names: Function
names: Similarity
messages: Belongs to the proline oxidase family.
messages: Converts proline to delta-1-pyrroline-5-carboxylate.

45286:AW171 hschr84676
gene id: 45286:AW171_hschr84676
uniprot id: A0A0X8HW71
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

45286:AW171 hschr31543
gene id: 45286:AW171_hschr31543
uniprot id: A0A109UY56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

45286:AW171 hschr63648
gene id: 45286:AW171_hschr63648
uniprot id: A0A0X8HUG2
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

45286:AW171 hschr63591
gene id: 45286:AW171_hschr63591
uniprot id: A0A109UZN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

45286:AW171 hschr63639
gene id: 45286:AW171_hschr63639
uniprot id: A0A0X8HTR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

45286:AW171 hschr52889
gene id: 45286:AW171_hschr52889
uniprot id: A0A0X8HT50
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

45286:AW171 hschr84700
gene id: 45286:AW171_hschr84700
uniprot id: A0A0X8HW64
names: Similarity
messages: Belongs to the anthranilate synthase component I family.

45286:AW171 hschr63927
gene id: 45286:AW171_hschr63927
uniprot id: A0A109UZT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

45286:AW171 hschr53058
gene id: 45286:AW171_hschr53058
uniprot id: A0A0X8HTG9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A monovalent cation.
messages: Belongs to the folylpolyglutamate synthase family.
messages: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Required for methionine synthesis and maintenance of intact mitochondrial DNA. Involved in telomere maintenance.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr74197
gene id: 45286:AW171_hschr74197
uniprot id: A0A0X8HVC2
names: Function
names: Similarity
messages: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the proteasome subunit S2 family.

45286:AW171 hschr32019
gene id: 45286:AW171_hschr32019
uniprot id: A0A120K219
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

45286:AW171 hschr2103
gene id: 45286:AW171_hschr2103
uniprot id: A0A125RDU2
names: Similarity
messages: Belongs to the WD repeat RTC1 family.

45286:AW171 hschr31669
gene id: 45286:AW171_hschr31669
uniprot id: A0A120K1Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIT family. Fungal FIT2B/SCS3 subfamily.
messages: Endoplasmic reticulum membrane
messages: Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.
messages: Membrane

45286:AW171 hschr53150
gene id: 45286:AW171_hschr53150
uniprot id: A0A0X8HTM6
names: Similarity
messages: Belongs to the NSRP1 family.

45286:AW171 hschr2175
gene id: 45286:AW171_hschr2175
uniprot id: A0A109UW45
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

45286:AW171 hschr2415
gene id: 45286:AW171_hschr2415
uniprot id: A0A109UXD4
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

45286:AW171 hschr2951
gene id: 45286:AW171_hschr2951
uniprot id: A0A109UX31
names: Similarity
messages: Belongs to the SGT1 family.

45286:AW171 hschr31542
gene id: 45286:AW171_hschr31542
uniprot id: A0A109UYK0
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

45286:AW171 hschr2539
gene id: 45286:AW171_hschr2539
uniprot id: A0A109UWT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

45286:AW171 hschr74049
gene id: 45286:AW171_hschr74049
uniprot id: A0A0X8HV20
names: Similarity
messages: Belongs to the CENP-X/MHF2 family.

45286:AW171 hschr42539
gene id: 45286:AW171_hschr42539
uniprot id: A0A0X8HSG6
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr63742
gene id: 45286:AW171_hschr63742
uniprot id: A0A0X8HUR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DLT1 family.
messages: Membrane
messages: Required for growth under high-pressure and low-temperature conditions.

45286:AW171 hschr245
gene id: 45286:AW171_hschr245
uniprot id: A0A120K0Q1
names: Similarity
messages: In the N-terminal section; belongs to the FGAMS family.

45286:AW171 hschr42246
gene id: 45286:AW171_hschr42246
uniprot id: A0A109UYU3
names: Similarity
messages: Belongs to the LST4 family.

45286:AW171 hschr221
gene id: 45286:AW171_hschr221
uniprot id: A0A109UW04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Mitochondrion inner membrane
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

45286:AW171 hschr74152
gene id: 45286:AW171_hschr74152
uniprot id: A0A0X8HUS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

45286:AW171 hschr63951
gene id: 45286:AW171_hschr63951
uniprot id: A0A0X8HUV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Nucleus

45286:AW171 hschr42372
gene id: 45286:AW171_hschr42372
uniprot id: A0A0X8HS70
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

45286:AW171 hschr52965
gene id: 45286:AW171_hschr52965
uniprot id: A0A109UZA1
names: Subcellular Location Annotation
messages: Membrane
messages: Preautophagosomal structure membrane

45286:AW171 hschr42154
gene id: 45286:AW171_hschr42154
uniprot id: A0A0X8HRS6
names: Similarity
messages: Belongs to the PRP18 family.

45286:AW171 hschr84720
gene id: 45286:AW171_hschr84720
uniprot id: A0A0X8HW97
names: Function
names: Similarity
messages: Belongs to the MnmG family.
messages: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.

45286:AW171 hschr31352
gene id: 45286:AW171_hschr31352
uniprot id: A0A120K1L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

45286:AW171 hschr31893
gene id: 45286:AW171_hschr31893
uniprot id: A0A0X8HRC0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Homodimer.

45286:AW171 hschr42406
gene id: 45286:AW171_hschr42406
uniprot id: A0A109UYR9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H3 family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

45286:AW171 hschr42240
gene id: 45286:AW171_hschr42240
uniprot id: A0A0X8HQX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

45286:AW171 hschr84599
gene id: 45286:AW171_hschr84599
uniprot id: A0A0X8HW83
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.

45286:AW171 hschr42464
gene id: 45286:AW171_hschr42464
uniprot id: A0A0X8HSD3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

45286:AW171 hschr21284
gene id: 45286:AW171_hschr21284
uniprot id: A0A109UXQ3
names: Similarity
messages: Belongs to the peptidase S8 family. Furin subfamily.

45286:AW171 hschr2106
gene id: 45286:AW171_hschr2106
uniprot id: A0A109UW17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

45286:AW171 hschr252
gene id: 45286:AW171_hschr252
uniprot id: A0A109UWP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

45286:AW171 hschr42230
gene id: 45286:AW171_hschr42230
uniprot id: A0A109UYV4
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr31368
gene id: 45286:AW171_hschr31368
uniprot id: A0A120K1L8
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr84974
gene id: 45286:AW171_hschr84974
uniprot id: A0A0X8HWR4
names: Similarity
messages: Belongs to the FGGY kinase family.

45286:AW171 hschr84574
gene id: 45286:AW171_hschr84574
uniprot id: A0A0X8HW21
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

45286:AW171 hschr53007
gene id: 45286:AW171_hschr53007
uniprot id: A0A0X8HT99
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA(4) but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B(4) as the product compared to the homologous mammalian enzyme (in vitro).
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

45286:AW171 hschr85021
gene id: 45286:AW171_hschr85021
uniprot id: A0A120K2Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX20 family.
messages: Involved in the assembly of the cytochrome c oxidase complex.
messages: Mitochondrion inner membrane

45286:AW171 hschr42686
gene id: 45286:AW171_hschr42686
uniprot id: A0A0X8HSP9
names: Similarity
messages: In the N-terminal section; belongs to the transposase 2 family.

45286:AW171 hschr42810
gene id: 45286:AW171_hschr42810
uniprot id: A0A0X8HSZ9
names: Similarity
messages: Belongs to the SEN15 family.

45286:AW171 hschr31698
gene id: 45286:AW171_hschr31698
uniprot id: A0A120K1X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. LDAH family.
messages: Lipid droplet

45286:AW171 hschr42844
gene id: 45286:AW171_hschr42844
uniprot id: A0A0X8HT15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase d subunit family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Mitochondrion inner membrane

45286:AW171 hschr84840
gene id: 45286:AW171_hschr84840
uniprot id: A0A0X8HWJ3
names: Function
names: Similarity
messages: Belongs to the adenylyl cyclase class-3 family.
messages: Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.

45286:AW171 hschr2348
gene id: 45286:AW171_hschr2348
uniprot id: A0A120K0Y8
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

45286:AW171 hschr53015
gene id: 45286:AW171_hschr53015
uniprot id: A0A0X8HT81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS3/PSF3 family.
messages: Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

45286:AW171 hschr31371
gene id: 45286:AW171_hschr31371
uniprot id: A0A109UXV1
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

45286:AW171 hschr84767
gene id: 45286:AW171_hschr84767
uniprot id: A0A0X8HWI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPF family.
messages: Nucleus

45286:AW171 hschr21229
gene id: 45286:AW171_hschr21229
uniprot id: A0A109UXN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IBD2 family.
messages: spindle pole

45286:AW171 hschr31355
gene id: 45286:AW171_hschr31355
uniprot id: A0A120K1M0
names: Similarity
messages: Belongs to the multicopper oxidase family.

45286:AW171 hschr53099
gene id: 45286:AW171_hschr53099
uniprot id: A0A109UXE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

45286:AW171 hschr74018
gene id: 45286:AW171_hschr74018
uniprot id: A0A0X8HV64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the VPS17 family.
messages: Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport.
messages: Component of the retromer complex.

45286:AW171 hschr42358
gene id: 45286:AW171_hschr42358
uniprot id: A0A0X8HS68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Vacuole membrane

45286:AW171 hschr53254
gene id: 45286:AW171_hschr53254
uniprot id: A0A0X8HTQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr31533
gene id: 45286:AW171_hschr31533
uniprot id: A0A109UY46
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

45286:AW171 hschr31980
gene id: 45286:AW171_hschr31980
uniprot id: A0A0X8HRI3
names: Similarity
messages: Belongs to the peptidase M24B family.

45286:AW171 hschr2352
gene id: 45286:AW171_hschr2352
uniprot id: A0A109UWJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWC3 family.
messages: Nucleus

45286:AW171 hschr42404
gene id: 45286:AW171_hschr42404
uniprot id: A0A0X8HS92
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr2930
gene id: 45286:AW171_hschr2930
uniprot id: A0A109UX68
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

45286:AW171 hschr53278
gene id: 45286:AW171_hschr53278
uniprot id: A0A109UXG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin GLFG family.
messages: Nucleus membrane
messages: nuclear pore complex

45286:AW171 hschr53265
gene id: 45286:AW171_hschr53265
uniprot id: A0A0X8HTV1
names: Similarity
messages: Belongs to the class-I DAHP synthase family.

45286:AW171 hschr63696
gene id: 45286:AW171_hschr63696
uniprot id: A0A0X8HUN0
names: Similarity
messages: Belongs to the proteasome subunit S9 family.

45286:AW171 hschr52908
gene id: 45286:AW171_hschr52908
uniprot id: A0A0X8HT62
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.
messages: Membrane
messages: Peroxisome membrane

45286:AW171 hschr52871
gene id: 45286:AW171_hschr52871
uniprot id: A0A109UZK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS4/SLD5 family.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

45286:AW171 hschr84771
gene id: 45286:AW171_hschr84771
uniprot id: A0A0X8HWH6
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr31325
gene id: 45286:AW171_hschr31325
uniprot id: A0A120K1L0
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

45286:AW171 hschr42745
gene id: 45286:AW171_hschr42745
uniprot id: A0A0X8HSR4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

45286:AW171 hschr2485
gene id: 45286:AW171_hschr2485
uniprot id: A0A125RDZ0
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr52887
gene id: 45286:AW171_hschr52887
uniprot id: A0A120K2A7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RIX1/PELP1 family.
messages: Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-60S ribosomal subunits. Regulates pre-60S association of the critical remodeling factor MDN1.
messages: Nucleus

45286:AW171 hschr2829
gene id: 45286:AW171_hschr2829
uniprot id: A0A120K153
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGG1 family.
messages: Nucleus

45286:AW171 hschr42312
gene id: 45286:AW171_hschr42312
uniprot id: A0A0X8HS30
names: Subcellular Location Annotation
messages: Nucleus
messages: kinetochore

45286:AW171 hschr42308
gene id: 45286:AW171_hschr42308
uniprot id: A0A120K247
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr63666
gene id: 45286:AW171_hschr63666
uniprot id: A0A0X8HUC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM31/MDM32 family.
messages: Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr31903
gene id: 45286:AW171_hschr31903
uniprot id: A0A0X8HRE4
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

45286:AW171 hschr42157
gene id: 45286:AW171_hschr42157
uniprot id: A0A0X8HRR1
names: Subcellular Location Annotation
messages: Peroxisome membrane

45286:AW171 hschr31404
gene id: 45286:AW171_hschr31404
uniprot id: A0A109UXZ5
names: Similarity
messages: In the C-terminal section; belongs to the DHPS family.
messages: In the N-terminal section; belongs to the DHNA family.

45286:AW171 hschr53174
gene id: 45286:AW171_hschr53174
uniprot id: A0A0X8HTK9
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

45286:AW171 hschr63531
gene id: 45286:AW171_hschr63531
uniprot id: A0A109UZM9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

45286:AW171 hschr52919
gene id: 45286:AW171_hschr52919
uniprot id: A0A0X8HT60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.
messages: Mitochondrion matrix

45286:AW171 hschr2253
gene id: 45286:AW171_hschr2253
uniprot id: A0A120K0V8
names: Similarity
messages: Belongs to the acetyltransferase family. MAK3 subfamily.

45286:AW171 hschr84721
gene id: 45286:AW171_hschr84721
uniprot id: A0A0X8HWF4
names: Function
names: Similarity
messages: Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.
messages: In the C-terminal section; belongs to the AIR synthase family.
messages: In the N-terminal section; belongs to the GARS family.

45286:AW171 hschr31527
gene id: 45286:AW171_hschr31527
uniprot id: A0A109UYJ2
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.

45286:AW171 hschr74052
gene id: 45286:AW171_hschr74052
uniprot id: A0A0X8HV85
names: Similarity
messages: Belongs to the mitochondrion-specific ribosomal protein mS38 family.

45286:AW171 hschr42321
gene id: 45286:AW171_hschr42321
uniprot id: A0A109UYR6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

45286:AW171 hschr42554
gene id: 45286:AW171_hschr42554
uniprot id: A0A0X8HRM0
names: Similarity
messages: Belongs to the complex I LYR family.

45286:AW171 hschr84835
gene id: 45286:AW171_hschr84835
uniprot id: A0A0X8HWF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

45286:AW171 hschr63876
gene id: 45286:AW171_hschr63876
uniprot id: A0A109UXU8
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6A family.

45286:AW171 hschr84791
gene id: 45286:AW171_hschr84791
uniprot id: A0A109V0L6
names: Similarity
messages: Belongs to the nucleoporin NSP1/NUP62 family.

45286:AW171 hschr2231
gene id: 45286:AW171_hschr2231
uniprot id: A0A125RDV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TEC1 family.
messages: Nucleus

45286:AW171 hschr84921
gene id: 45286:AW171_hschr84921
uniprot id: A0A109UYN1
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

45286:AW171 hschr2487
gene id: 45286:AW171_hschr2487
uniprot id: A0A109UX64
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr84799
gene id: 45286:AW171_hschr84799
uniprot id: A0A0X8HWF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

45286:AW171 hschr84715
gene id: 45286:AW171_hschr84715
uniprot id: A0A0X8HW78
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

45286:AW171 hschr42460
gene id: 45286:AW171_hschr42460
uniprot id: A0A120K263
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

45286:AW171 hschr42515
gene id: 45286:AW171_hschr42515
uniprot id: A0A0X8HSH2
names: Similarity
messages: Belongs to the OMP decarboxylase family.

45286:AW171 hschr31589
gene id: 45286:AW171_hschr31589
uniprot id: A0A109UY79
names: Similarity
messages: Belongs to the terpene cyclase/mutase family.

45286:AW171 hschr52924
gene id: 45286:AW171_hschr52924
uniprot id: A0A0X8HT70
names: Function
names: Similarity
messages: Belongs to the flavokinase family.
messages: Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.

45286:AW171 hschr84818
gene id: 45286:AW171_hschr84818
uniprot id: A0A0X8HWK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGM family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.
messages: Membrane

45286:AW171 hschr53356
gene id: 45286:AW171_hschr53356
uniprot id: A0A120K2F5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.

45286:AW171 hschr31778
gene id: 45286:AW171_hschr31778
uniprot id: A0A0X8HQ53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the REI1 family.
messages: Cytoplasm

45286:AW171 hschr42162
gene id: 45286:AW171_hschr42162
uniprot id: A0A0X8HQT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

45286:AW171 hschr74115
gene id: 45286:AW171_hschr74115
uniprot id: A0A0X8HVC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAC-alpha family.
messages: Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD2 may also be involved in transcription regulation.
messages: Cytoplasm
messages: Nucleus

45286:AW171 hschr2940
gene id: 45286:AW171_hschr2940
uniprot id: A0A109UX16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr42116
gene id: 45286:AW171_hschr42116
uniprot id: A0A0X8HQQ7
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr2321
gene id: 45286:AW171_hschr2321
uniprot id: A0A109UWH6
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.

45286:AW171 hschr52900
gene id: 45286:AW171_hschr52900
uniprot id: A0A109UZA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

45286:AW171 hschr74445
gene id: 45286:AW171_hschr74445
uniprot id: A0A0X8HVR5
names: Subcellular Location Annotation
messages: nuclear pore complex

45286:AW171 hschr2351
gene id: 45286:AW171_hschr2351
uniprot id: A0A120K0Y6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MDM10 family.
messages: Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex.
messages: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.
messages: Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.
messages: Mitochondrion outer membrane

45286:AW171 hschr42390
gene id: 45286:AW171_hschr42390
uniprot id: A0A0X8HS44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC123 family.
messages: Cytoplasm
messages: Regulates the cell cycle in a nutrient dependent manner.

45286:AW171 hschr31572
gene id: 45286:AW171_hschr31572
uniprot id: A0A109UYL9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.
messages: Chromosome
messages: Component of the COMPASS (Set1C) complex.
messages: Nucleus

45286:AW171 hschr31895
gene id: 45286:AW171_hschr31895
uniprot id: A0A109UYM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

45286:AW171 hschr84738
gene id: 45286:AW171_hschr84738
uniprot id: A0A0X8HW94
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr63987
gene id: 45286:AW171_hschr63987
uniprot id: A0A109UZW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YME2 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.

45286:AW171 hschr42215
gene id: 45286:AW171_hschr42215
uniprot id: A0A120K239
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

45286:AW171 hschr53111
gene id: 45286:AW171_hschr53111
uniprot id: A0A0X8HTI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

45286:AW171 hschr42448
gene id: 45286:AW171_hschr42448
uniprot id: A0A120K266
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

45286:AW171 hschr42777
gene id: 45286:AW171_hschr42777
uniprot id: A0A0X8HSY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H3 family.
messages: Nucleus

45286:AW171 hschr53272
gene id: 45286:AW171_hschr53272
uniprot id: A0A0X8HT25
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

45286:AW171 hschr53143
gene id: 45286:AW171_hschr53143
uniprot id: A0A109UZK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

45286:AW171 hschr63789
gene id: 45286:AW171_hschr63789
uniprot id: A0A120K2K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OSBP family.
messages: Membrane

45286:AW171 hschr31767
gene id: 45286:AW171_hschr31767
uniprot id: A0A109UYI4
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.

45286:AW171 hschr74222
gene id: 45286:AW171_hschr74222
uniprot id: A0A109V092
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad17/RAD24 family.
messages: Nucleus

45286:AW171 hschr63771
gene id: 45286:AW171_hschr63771
uniprot id: A0A109UZT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SHE2 family.
messages: Nucleus

45286:AW171 hschr31799
gene id: 45286:AW171_hschr31799
uniprot id: A0A120K1Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

45286:AW171 hschr2170
gene id: 45286:AW171_hschr2170
uniprot id: A0A109UW57
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr53081
gene id: 45286:AW171_hschr53081
uniprot id: A0A109UZ90
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Belongs to the Clp1 family. NOL9/GRC3 subfamily.
messages: Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.

45286:AW171 hschr266
gene id: 45286:AW171_hschr266
uniprot id: A0A109UW05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRE11/RAD32 family.
messages: Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
messages: Nucleus

45286:AW171 hschr53030
gene id: 45286:AW171_hschr53030
uniprot id: A0A0X8HT90
names: Function
names: Similarity
messages: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the peptidase M67A family.

45286:AW171 hschr2194
gene id: 45286:AW171_hschr2194
uniprot id: A0A109UWY9
names: Similarity
messages: Belongs to the RCAN family.

45286:AW171 hschr53304
gene id: 45286:AW171_hschr53304
uniprot id: A0A0X8HT46
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr63811
gene id: 45286:AW171_hschr63811
uniprot id: A0A0X8HUU4
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr2497
gene id: 45286:AW171_hschr2497
uniprot id: A0A109UXI9
names: Subcellular Location Annotation
messages: nucleolus

45286:AW171 hschr282
gene id: 45286:AW171_hschr282
uniprot id: A0A109UW16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1 and EAP1 for binding to eIF4E and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA.
messages: Belongs to the CAF20 family.
messages: Cytoplasm

45286:AW171 hschr84585
gene id: 45286:AW171_hschr84585
uniprot id: A0A0X8HW10
names: Subcellular Location Annotation
messages: nucleolus

45286:AW171 hschr2964
gene id: 45286:AW171_hschr2964
uniprot id: A0A109UX34
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

45286:AW171 hschr21161
gene id: 45286:AW171_hschr21161
uniprot id: A0A120K1F5
names: Similarity
messages: Belongs to the TRL1 family.

45286:AW171 hschr21115
gene id: 45286:AW171_hschr21115
uniprot id: A0A120K1E4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr2931
gene id: 45286:AW171_hschr2931
uniprot id: A0A109UX41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
messages: Nucleus

45286:AW171 hschr53264
gene id: 45286:AW171_hschr53264
uniprot id: A0A0X8HTT1
names: Function
names: Similarity
messages: Belongs to the HisA/HisF family.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.
messages: In the C-terminal section; belongs to the HisA/HisF family.

45286:AW171 hschr74071
gene id: 45286:AW171_hschr74071
uniprot id: A0A0X8HUM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCO1/2 family.
messages: Mitochondrion inner membrane

45286:AW171 hschr85042
gene id: 45286:AW171_hschr85042
uniprot id: A0A0X8HWU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck

45286:AW171 hschr2952
gene id: 45286:AW171_hschr2952
uniprot id: A0A120K190
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOB1 family.
messages: Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm.
messages: nucleolus

45286:AW171 hschr74180
gene id: 45286:AW171_hschr74180
uniprot id: A0A109V015
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
messages: Nucleus

45286:AW171 hschr53447
gene id: 45286:AW171_hschr53447
uniprot id: A0A120K2G9
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr74005
gene id: 45286:AW171_hschr74005
uniprot id: A0A0X8HV28
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

45286:AW171 hschr63730
gene id: 45286:AW171_hschr63730
uniprot id: A0A0X8HUP5
names: Similarity
messages: Belongs to the CCDC25 family.

45286:AW171 hschr2929
gene id: 45286:AW171_hschr2929
uniprot id: A0A109UXU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.
messages: Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.
messages: Cytoplasm
messages: P-body

45286:AW171 hschr84757
gene id: 45286:AW171_hschr84757
uniprot id: A0A0X8HWE2
names: Similarity
messages: Belongs to the glycosyltransferase 32 family.

45286:AW171 hschr63631
gene id: 45286:AW171_hschr63631
uniprot id: A0A0X8HUF1
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.

45286:AW171 hschr53050
gene id: 45286:AW171_hschr53050
uniprot id: A0A0X8HTE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

45286:AW171 hschr85046
gene id: 45286:AW171_hschr85046
uniprot id: A0A0X8HWX4
names: Similarity
messages: Belongs to the AHA1 family.

45286:AW171 hschr31933
gene id: 45286:AW171_hschr31933
uniprot id: A0A0X8HRG2
names: Similarity
messages: Belongs to the IWR1/SLC7A6OS family.

45286:AW171 hschr21041
gene id: 45286:AW171_hschr21041
uniprot id: A0A125RE26
names: Function
messages: Cleaves A-5'-PPP-5'A to yield AMP and ADP. Can cleave all dinucleoside polyphosphates, provided the phosphate chain contains at least 3 phosphates and that 1 of the 2 bases composing the nucleotide is a purine. Is most effective on dinucleoside triphosphates. Negatively regulates intracellular dinucleoside polyphosphate levels, which elevate following heat shock.

45286:AW171 hschr63855
gene id: 45286:AW171_hschr63855
uniprot id: A0A109UZQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFT1 family.
messages: Endoplasmic reticulum membrane
messages: May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane.
messages: Membrane

45286:AW171 hschr53326
gene id: 45286:AW171_hschr53326
uniprot id: A0A109UZJ5
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

45286:AW171 hschr63978
gene id: 45286:AW171_hschr63978
uniprot id: A0A0X8HUZ5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

45286:AW171 hschr85056
gene id: 45286:AW171_hschr85056
uniprot id: A0A0X8HWW3
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

45286:AW171 hschr42182
gene id: 45286:AW171_hschr42182
uniprot id: A0A109UYU6
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

45286:AW171 hschr31875
gene id: 45286:AW171_hschr31875
uniprot id: A0A0X8HRB7
names: Similarity
messages: Belongs to the aspartokinase family.

45286:AW171 hschr42789
gene id: 45286:AW171_hschr42789
uniprot id: A0A0X8HSX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

45286:AW171 hschr42269
gene id: 45286:AW171_hschr42269
uniprot id: A0A0X8HRX5
names: Similarity
messages: Belongs to the GcvT family. CAF17 subfamily.

45286:AW171 hschr53065
gene id: 45286:AW171_hschr53065
uniprot id: A0A0X8HTF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.
messages: Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5.
messages: Nucleus

45286:AW171 hschr42749
gene id: 45286:AW171_hschr42749
uniprot id: A0A0X8HS41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr21036
gene id: 45286:AW171_hschr21036
uniprot id: A0A109UXC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM24 family.
messages: Mitochondrion

45286:AW171 hschr52945
gene id: 45286:AW171_hschr52945
uniprot id: A0A0X8HT67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family.
messages: Nucleus matrix
messages: cytoskeleton

45286:AW171 hschr42470
gene id: 45286:AW171_hschr42470
uniprot id: A0A0X8HSB8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

45286:AW171 hschr21009
gene id: 45286:AW171_hschr21009
uniprot id: A0A109UXC1
names: Similarity
messages: Belongs to the glutaredoxin family.

45286:AW171 hschr42142
gene id: 45286:AW171_hschr42142
uniprot id: A0A0X8HRQ4
names: Subcellular Location Annotation
messages: nucleolus

45286:AW171 hschr21235
gene id: 45286:AW171_hschr21235
uniprot id: A0A109UXL7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Mitochondrion inner membrane

45286:AW171 hschr31466
gene id: 45286:AW171_hschr31466
uniprot id: A0A109UY34
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion

45286:AW171 hschr2903
gene id: 45286:AW171_hschr2903
uniprot id: A0A109UX01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OSBP family.
messages: Membrane

45286:AW171 hschr63721
gene id: 45286:AW171_hschr63721
uniprot id: A0A109UZP7
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.

45286:AW171 hschr21206
gene id: 45286:AW171_hschr21206
uniprot id: A0A109UXJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

45286:AW171 hschr42771
gene id: 45286:AW171_hschr42771
uniprot id: A0A109UZI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEF1 family.
messages: Cytoplasm
messages: Nucleus
messages: telomere

45286:AW171 hschr52973
gene id: 45286:AW171_hschr52973
uniprot id: A0A0X8HT78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WHI5/NRM1 family.
messages: Cytoplasm
messages: Nucleus

45286:AW171 hschr31913
gene id: 45286:AW171_hschr31913
uniprot id: A0A109UZ06
names: Similarity
messages: Belongs to the lipin family.

45286:AW171 hschr21171
gene id: 45286:AW171_hschr21171
uniprot id: A0A109UXK1
names: Similarity
messages: Belongs to the SAPS family.

45286:AW171 hschr63965
gene id: 45286:AW171_hschr63965
uniprot id: A0A0X8HUX0
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr21140
gene id: 45286:AW171_hschr21140
uniprot id: A0A109UVH6
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr31711
gene id: 45286:AW171_hschr31711
uniprot id: A0A109UYV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr2912
gene id: 45286:AW171_hschr2912
uniprot id: A0A109UXT1
names: Similarity
messages: Belongs to the actin family.

45286:AW171 hschr84855
gene id: 45286:AW171_hschr84855
uniprot id: A0A0X8HWK3
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

45286:AW171 hschr21201
gene id: 45286:AW171_hschr21201
uniprot id: A0A109UXP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC2 family.
messages: Nucleus

45286:AW171 hschr74029
gene id: 45286:AW171_hschr74029
uniprot id: A0A109UZY6
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

45286:AW171 hschr2950
gene id: 45286:AW171_hschr2950
uniprot id: A0A109UXI1
names: Similarity
messages: Belongs to the MAP65/ASE1 family.

45286:AW171 hschr2547
gene id: 45286:AW171_hschr2547
uniprot id: A0A109UWT8
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

45286:AW171 hschr74041
gene id: 45286:AW171_hschr74041
uniprot id: A0A109UZX9
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family.

45286:AW171 hschr63588
gene id: 45286:AW171_hschr63588
uniprot id: A0A0X8HUC9
names: Similarity
messages: Belongs to the putative lipase ROG1 family.

45286:AW171 hschr63707
gene id: 45286:AW171_hschr63707
uniprot id: A0A109UZS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Mitochondrion inner membrane

45286:AW171 hschr21246
gene id: 45286:AW171_hschr21246
uniprot id: A0A109UVQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat IPI3/WDR18 family.
messages: Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.
messages: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.
messages: Nucleus

45286:AW171 hschr53126
gene id: 45286:AW171_hschr53126
uniprot id: A0A0X8HTJ2
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr21273
gene id: 45286:AW171_hschr21273
uniprot id: A0A120K1J7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cytoplasm
messages: Nucleus
messages: Preautophagosomal structure
messages: Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.

45286:AW171 hschr84869
gene id: 45286:AW171_hschr84869
uniprot id: A0A0X8HWL6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

45286:AW171 hschr2845
gene id: 45286:AW171_hschr2845
uniprot id: A0A120K167
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

45286:AW171 hschr2424
gene id: 45286:AW171_hschr2424
uniprot id: A0A120K125
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

45286:AW171 hschr31379
gene id: 45286:AW171_hschr31379
uniprot id: A0A109UXU5
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr63489
gene id: 45286:AW171_hschr63489
uniprot id: A0A0X8HU83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM6/GCD10 family.
messages: Heterotetramer.
messages: Nucleus
messages: Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

45286:AW171 hschr63867
gene id: 45286:AW171_hschr63867
uniprot id: A0A0X8HUT1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.
messages: Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

45286:AW171 hschr2285
gene id: 45286:AW171_hschr2285
uniprot id: A0A120K0W7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

45286:AW171 hschr63801
gene id: 45286:AW171_hschr63801
uniprot id: A0A0X8HUM8
names: Function
names: Similarity
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.

45286:AW171 hschr31547
gene id: 45286:AW171_hschr31547
uniprot id: A0A120K1T0
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

45286:AW171 hschr31934
gene id: 45286:AW171_hschr31934
uniprot id: A0A0X8HRF5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

45286:AW171 hschr74492
gene id: 45286:AW171_hschr74492
uniprot id: A0A0X8HVU3
names: Similarity
messages: Belongs to the hexokinase family.

45286:AW171 hschr84505
gene id: 45286:AW171_hschr84505
uniprot id: A0A0X8HW19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Nucleus

45286:AW171 hschr21188
gene id: 45286:AW171_hschr21188
uniprot id: A0A109UVK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-50 family.
messages: Membrane

45286:AW171 hschr74213
gene id: 45286:AW171_hschr74213
uniprot id: A0A0X8HVD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

45286:AW171 hschr2935
gene id: 45286:AW171_hschr2935
uniprot id: A0A109UX23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Membrane

45286:AW171 hschr74355
gene id: 45286:AW171_hschr74355
uniprot id: A0A0X8HVK1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

45286:AW171 hschr84747
gene id: 45286:AW171_hschr84747
uniprot id: A0A109UYI5
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr74275
gene id: 45286:AW171_hschr74275
uniprot id: A0A0X8HVN6
names: Similarity
messages: Belongs to the R-transferase family.

45286:AW171 hschr63621
gene id: 45286:AW171_hschr63621
uniprot id: A0A0X8HUF0
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.
messages: Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.

45286:AW171 hschr42068
gene id: 45286:AW171_hschr42068
uniprot id: A0A0X8HRN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BOS1 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: SNARE required for protein transport between the ER and the Golgi complex.

45286:AW171 hschr31373
gene id: 45286:AW171_hschr31373
uniprot id: A0A109UXX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP3 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the lipid remodeling steps of GPI-anchor maturation.
messages: Membrane

45286:AW171 hschr63776
gene id: 45286:AW171_hschr63776
uniprot id: A0A0X8HUK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 17 family.
messages: cell wall

45286:AW171 hschr42094
gene id: 45286:AW171_hschr42094
uniprot id: A0A0X8HRN6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

45286:AW171 hschr42755
gene id: 45286:AW171_hschr42755
uniprot id: A0A109UX60
names: Similarity
messages: Belongs to the MGR2 family.

45286:AW171 hschr84571
gene id: 45286:AW171_hschr84571
uniprot id: A0A0X8HVY6
names: Similarity
messages: Belongs to the GroES chaperonin family.

45286:AW171 hschr85007
gene id: 45286:AW171_hschr85007
uniprot id: A0A120K2Y0
names: Similarity
messages: Belongs to the universal ribosomal protein uS10 family.

45286:AW171 hschr63592
gene id: 45286:AW171_hschr63592
uniprot id: A0A0X8HUA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
messages: Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
messages: Nucleus

45286:AW171 hschr31949
gene id: 45286:AW171_hschr31949
uniprot id: A0A0X8HRG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC31 family.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr31372
gene id: 45286:AW171_hschr31372
uniprot id: A0A120K1M2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC25 family.
messages: Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.
messages: Nucleus
messages: kinetochore

45286:AW171 hschr21029
gene id: 45286:AW171_hschr21029
uniprot id: A0A109UX88
names: Similarity
messages: Belongs to the ATPase delta chain family.

45286:AW171 hschr53000
gene id: 45286:AW171_hschr53000
uniprot id: A0A0X8HT71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA43 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

45286:AW171 hschr74367
gene id: 45286:AW171_hschr74367
uniprot id: A0A0X8HVN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAT1 family.
messages: Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.
messages: Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.
messages: Cytoplasm
messages: Nucleus

45286:AW171 hschr84976
gene id: 45286:AW171_hschr84976
uniprot id: A0A0X8HWX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family.
messages: Nucleus

45286:AW171 hschr42254
gene id: 45286:AW171_hschr42254
uniprot id: A0A0X8HRY6
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

45286:AW171 hschr31826
gene id: 45286:AW171_hschr31826
uniprot id: A0A0X8HQ78
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

45286:AW171 hschr63854
gene id: 45286:AW171_hschr63854
uniprot id: A0A0X8HUU7
names: Similarity
messages: Belongs to the NFYB/HAP3 subunit family.

45286:AW171 hschr84627
gene id: 45286:AW171_hschr84627
uniprot id: A0A120K2T7
names: Function
names: Similarity
messages: Belongs to the VPS16 family.
messages: Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.

45286:AW171 hschr2436
gene id: 45286:AW171_hschr2436
uniprot id: A0A109UWP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STAM family.
messages: Component of the ESCRT-0 complex composed of HSE1 and VPS27.
messages: Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).
messages: Endosome membrane
messages: Membrane

45286:AW171 hschr74161
gene id: 45286:AW171_hschr74161
uniprot id: A0A0X8HVA2
names: Similarity
messages: Belongs to the SH3YL1 family.

45286:AW171 hschr52988
gene id: 45286:AW171_hschr52988
uniprot id: A0A0X8HT87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

45286:AW171 hschr85065
gene id: 45286:AW171_hschr85065
uniprot id: A0A109V0H5
names: Similarity
messages: Belongs to the TIP41 family.

45286:AW171 hschr52969
gene id: 45286:AW171_hschr52969
uniprot id: A0A0X8HT84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
messages: Component of the pre-66S ribosomal particle.
messages: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.
messages: nucleolus

45286:AW171 hschr63831
gene id: 45286:AW171_hschr63831
uniprot id: A0A0X8HUW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.
messages: Belongs to the replication factor A protein 1 family.
messages: Component of the heterotrimeric canonical replication protein A complex (RPA).
messages: Nucleus

45286:AW171 hschr267
gene id: 45286:AW171_hschr267
uniprot id: A0A125RDT7
names: Similarity
messages: Belongs to the phosducin family.

45286:AW171 hschr52877
gene id: 45286:AW171_hschr52877
uniprot id: A0A0X8HT65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool.
messages: Belongs to the complex I LYR family. MZM1 subfamily.
messages: Interacts with RIP1.
messages: Mitochondrion matrix

45286:AW171 hschr53235
gene id: 45286:AW171_hschr53235
uniprot id: A0A0X8HTQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

45286:AW171 hschr2944
gene id: 45286:AW171_hschr2944
uniprot id: A0A109UXV0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

45286:AW171 hschr293
gene id: 45286:AW171_hschr293
uniprot id: A0A120K0R0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Cytoplasm
messages: Mevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway. The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins.

45286:AW171 hschr31532
gene id: 45286:AW171_hschr31532
uniprot id: A0A120K1S5
names: Similarity
messages: Belongs to the SUN family.

45286:AW171 hschr84871
gene id: 45286:AW171_hschr84871
uniprot id: A0A0X8HWL3
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. Interacts with pstB2. This interaction may be a means to structurally tether the donor membrane (ER) harboring PstB2 to acceptor membranes (Golgi/endosomes) harboring PSD2 during PtdSer transport to the site of PtdEtn synthesis.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: The C2 domains have an essential, but non-catalytic function. They may facilitate interaction with PstB2 and are required for lipid transport function.

45286:AW171 hschr31558
gene id: 45286:AW171_hschr31558
uniprot id: A0A109UY71
names: Similarity
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.

45286:AW171 hschr52959
gene id: 45286:AW171_hschr52959
uniprot id: A0A0X8HSH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PRP19 family.
messages: Homotetramer.
messages: Nucleus
messages: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.

45286:AW171 hschr53151
gene id: 45286:AW171_hschr53151
uniprot id: A0A0X8HTK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-A family.
messages: Mitochondrion

45286:AW171 hschr74224
gene id: 45286:AW171_hschr74224
uniprot id: A0A109UZZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

45286:AW171 hschr42571
gene id: 45286:AW171_hschr42571
uniprot id: A0A109UZ79
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

45286:AW171 hschr2372
gene id: 45286:AW171_hschr2372
uniprot id: A0A125RDX6
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

45286:AW171 hschr74016
gene id: 45286:AW171_hschr74016
uniprot id: A0A0X8HUZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPF family.
messages: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
messages: Interacts with EME1.
messages: Nucleus

45286:AW171 hschr42751
gene id: 45286:AW171_hschr42751
uniprot id: A0A109UZ15
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

45286:AW171 hschr2889
gene id: 45286:AW171_hschr2889
uniprot id: A0A120K171
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

45286:AW171 hschr31580
gene id: 45286:AW171_hschr31580
uniprot id: A0A109UYB3
names: Similarity
messages: Belongs to the MIP18 family.

45286:AW171 hschr74085
gene id: 45286:AW171_hschr74085
uniprot id: A0A0X8HV59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC1 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Nucleus
messages: ORC is composed of six subunits.

45286:AW171 hschr31363
gene id: 45286:AW171_hschr31363
uniprot id: A0A109UVW7
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

45286:AW171 hschr74203
gene id: 45286:AW171_hschr74203
uniprot id: A0A0X8HVD3
names: Similarity
messages: Belongs to the peptidase S10 family.

45286:AW171 hschr31300
gene id: 45286:AW171_hschr31300
uniprot id: A0A109UXT0
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr31963
gene id: 45286:AW171_hschr31963
uniprot id: A0A0X8HRH2
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.

45286:AW171 hschr2849
gene id: 45286:AW171_hschr2849
uniprot id: A0A109UWZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated with ATG12.
messages: Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.
messages: Membrane
messages: Preautophagosomal structure membrane

45286:AW171 hschr251
gene id: 45286:AW171_hschr251
uniprot id: A0A125RDT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

45286:AW171 hschr31553
gene id: 45286:AW171_hschr31553
uniprot id: A0A109UYC4
names: Similarity
messages: Belongs to the cytochrome b5 family.

45286:AW171 hschr53262
gene id: 45286:AW171_hschr53262
uniprot id: A0A120K2F1
names: Similarity
messages: Belongs to the bystin family.

45286:AW171 hschr63772
gene id: 45286:AW171_hschr63772
uniprot id: A0A109V045
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: actin patch

45286:AW171 hschr31455
gene id: 45286:AW171_hschr31455
uniprot id: A0A109UW23
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

45286:AW171 hschr63877
gene id: 45286:AW171_hschr63877
uniprot id: A0A109UZV3
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

45286:AW171 hschr85075
gene id: 45286:AW171_hschr85075
uniprot id: A0A0X8HX40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

45286:AW171 hschr84522
gene id: 45286:AW171_hschr84522
uniprot id: A0A0X8HVZ0
names: Function
names: Similarity
messages: Belongs to the VPS35 family.
messages: Plays a role in vesicular protein sorting.

45286:AW171 hschr31667
gene id: 45286:AW171_hschr31667
uniprot id: A0A120K1W3
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

45286:AW171 hschr2174
gene id: 45286:AW171_hschr2174
uniprot id: A0A120K0T5
names: Similarity
messages: Belongs to the thioredoxin family.

45286:AW171 hschr42326
gene id: 45286:AW171_hschr42326
uniprot id: A0A109UZK2
names: Similarity
messages: Belongs to the VPS25 family.

45286:AW171 hschr74265
gene id: 45286:AW171_hschr74265
uniprot id: A0A0X8HVH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

45286:AW171 hschr42657
gene id: 45286:AW171_hschr42657
uniprot id: A0A109UZ54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.
messages: cytoskeleton

45286:AW171 hschr63966
gene id: 45286:AW171_hschr63966
uniprot id: A0A0X8HUW5
names: Function
names: Similarity
messages: Belongs to the peptidase T1A family.
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

45286:AW171 hschr74260
gene id: 45286:AW171_hschr74260
uniprot id: A0A0X8HVF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RRP8 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.
messages: nucleolus

45286:AW171 hschr31829
gene id: 45286:AW171_hschr31829
uniprot id: A0A0X8HR83
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GET2 family.
messages: Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.

45286:AW171 hschr42346
gene id: 45286:AW171_hschr42346
uniprot id: A0A0X8HS85
names: Subcellular Location Annotation
messages: Cytoplasm

45286:AW171 hschr42097
gene id: 45286:AW171_hschr42097
uniprot id: A0A0X8HRR5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

45286:AW171 hschr21027
gene id: 45286:AW171_hschr21027
uniprot id: A0A109UX80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL67 family.
messages: Mitochondrion

45286:AW171 hschr42355
gene id: 45286:AW171_hschr42355
uniprot id: A0A120K253
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

45286:AW171 hschr53404
gene id: 45286:AW171_hschr53404
uniprot id: A0A120K2G3
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr53071
gene id: 45286:AW171_hschr53071
uniprot id: A0A120K2C7
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

45286:AW171 hschr21154
gene id: 45286:AW171_hschr21154
uniprot id: A0A109UY89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr42290
gene id: 45286:AW171_hschr42290
uniprot id: A0A109UZ12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

45286:AW171 hschr2187
gene id: 45286:AW171_hschr2187
uniprot id: A0A120K0T8
names: Similarity
messages: Belongs to the IlvD/Edd family.

45286:AW171 hschr42417
gene id: 45286:AW171_hschr42417
uniprot id: A0A109UWY7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS23 family.
messages: Component of the mitochondrial small ribosomal subunit.
messages: Mitochondrion

45286:AW171 hschr2280
gene id: 45286:AW171_hschr2280
uniprot id: A0A120K0W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM3 family.
messages: Membrane raft

45286:AW171 hschr53128
gene id: 45286:AW171_hschr53128
uniprot id: A0A0X8HTH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP5 family.
messages: Cytoplasm
messages: Nucleus

45286:AW171 hschr21002
gene id: 45286:AW171_hschr21002
uniprot id: A0A120K1B0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion

45286:AW171 hschr31331
gene id: 45286:AW171_hschr31331
uniprot id: A0A109UXX5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC1 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr31908
gene id: 45286:AW171_hschr31908
uniprot id: A0A109UYS6
names: Similarity
messages: Belongs to the lysophospholipase family.

45286:AW171 hschr42540
gene id: 45286:AW171_hschr42540
uniprot id: A0A109UZ04
names: Similarity
names: Subunit
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.

45286:AW171 hschr42705
gene id: 45286:AW171_hschr42705
uniprot id: A0A109UZ05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mitochondrion inner membrane

45286:AW171 hschr2441
gene id: 45286:AW171_hschr2441
uniprot id: A0A120K116
names: Similarity
messages: Belongs to the UPL family. K-HECT subfamily.

45286:AW171 hschr2397
gene id: 45286:AW171_hschr2397
uniprot id: A0A120K101
names: Similarity
messages: Belongs to the phosphohexose mutase family.

45286:AW171 hschr53187
gene id: 45286:AW171_hschr53187
uniprot id: A0A0X8HTN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr63800
gene id: 45286:AW171_hschr63800
uniprot id: A0A109UZP0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Mitochondrion

45286:AW171 hschr2233
gene id: 45286:AW171_hschr2233
uniprot id: A0A109UWP7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL19 family.

45286:AW171 hschr63815
gene id: 45286:AW171_hschr63815
uniprot id: A0A0X8HUS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM21 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr53366
gene id: 45286:AW171_hschr53366
uniprot id: A0A0X8HT96
names: Similarity
messages: Belongs to the heat shock protein 90 family.

45286:AW171 hschr84783
gene id: 45286:AW171_hschr84783
uniprot id: A0A0X8HWD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPC29 family.
messages: Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication. Links the central plaque component SPC42 to the inner plaque component SPC110.
messages: Nucleus
messages: spindle pole body

45286:AW171 hschr21187
gene id: 45286:AW171_hschr21187
uniprot id: A0A109UXK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HEATR1/UTP10 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

45286:AW171 hschr63684
gene id: 45286:AW171_hschr63684
uniprot id: A0A0X8HUL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

45286:AW171 hschr42643
gene id: 45286:AW171_hschr42643
uniprot id: A0A0X8HSP2
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr74364
gene id: 45286:AW171_hschr74364
uniprot id: A0A109UY66
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

45286:AW171 hschr85048
gene id: 45286:AW171_hschr85048
uniprot id: A0A0X8HWX6
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

45286:AW171 hschr63888
gene id: 45286:AW171_hschr63888
uniprot id: A0A109UZU5
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

45286:AW171 hschr2282
gene id: 45286:AW171_hschr2282
uniprot id: A0A120K0X6
names: Function
messages: Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.

45286:AW171 hschr53185
gene id: 45286:AW171_hschr53185
uniprot id: A0A0X8HTL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Membrane
messages: nuclear pore complex

45286:AW171 hschr2544
gene id: 45286:AW171_hschr2544
uniprot id: A0A109UWZ2
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

45286:AW171 hschr23
gene id: 45286:AW171_hschr23
uniprot id: A0A109UVW0
names: Similarity
messages: Belongs to the peptidase A1 family.

45286:AW171 hschr53142
gene id: 45286:AW171_hschr53142
uniprot id: A0A0X8HTK3
names: Similarity
messages: Belongs to the MAK16 family.

45286:AW171 hschr63501
gene id: 45286:AW171_hschr63501
uniprot id: A0A0X8HU84
names: Similarity
messages: Belongs to the ribose 5-phosphate isomerase family.

45286:AW171 hschr74458
gene id: 45286:AW171_hschr74458
uniprot id: A0A0X8HVD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Chromosome
messages: Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
messages: Nucleus

45286:AW171 hschr42445
gene id: 45286:AW171_hschr42445
uniprot id: A0A120K262
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr63634
gene id: 45286:AW171_hschr63634
uniprot id: A0A0X8HUB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

45286:AW171 hschr31574
gene id: 45286:AW171_hschr31574
uniprot id: A0A120K1T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAF1 family.
messages: Nucleus

45286:AW171 hschr84628
gene id: 45286:AW171_hschr84628
uniprot id: A0A0X8HW41
names: Similarity
messages: Belongs to the SKP1 family.

45286:AW171 hschr84514
gene id: 45286:AW171_hschr84514
uniprot id: A0A109V090
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

45286:AW171 hschr2880
gene id: 45286:AW171_hschr2880
uniprot id: A0A109UX17
names: Similarity
messages: Belongs to the PPP phosphatase family.

45286:AW171 hschr2925
gene id: 45286:AW171_hschr2925
uniprot id: A0A109UX06
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

45286:AW171 hschr74012
gene id: 45286:AW171_hschr74012
uniprot id: A0A109V0J8
names: Similarity
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Octamer of two non-identical subunits IDH1 and IDH2.

45286:AW171 hschr53467
gene id: 45286:AW171_hschr53467
uniprot id: A0A0X8HU86
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr32029
gene id: 45286:AW171_hschr32029
uniprot id: A0A0X8HRM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr31612
gene id: 45286:AW171_hschr31612
uniprot id: A0A109UWB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the C1D family.
messages: Nucleus
messages: Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.

45286:AW171 hschr53353
gene id: 45286:AW171_hschr53353
uniprot id: A0A109UZI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fungal TPase family.
messages: First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.
messages: Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.
messages: Nucleus

45286:AW171 hschr63775
gene id: 45286:AW171_hschr63775
uniprot id: A0A0X8HUL4
names: Function
names: Similarity
messages: Belongs to the SPG4 family.
messages: Stationary phase-essential protein not required for growth on nonfermentable carbon sources.

45286:AW171 hschr63986
gene id: 45286:AW171_hschr63986
uniprot id: A0A0X8HV19
names: Similarity
messages: Belongs to the peptidase C19 family.

45286:AW171 hschr85101
gene id: 45286:AW171_hschr85101
uniprot id: A0A120K2Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

45286:AW171 hschr84964
gene id: 45286:AW171_hschr84964
uniprot id: A0A0X8HWB5
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

45286:AW171 hschr31479
gene id: 45286:AW171_hschr31479
uniprot id: A0A109UY17
names: Subunit
messages: Homodimer.

45286:AW171 hschr52980
gene id: 45286:AW171_hschr52980
uniprot id: A0A120K2C1
names: Function
names: Similarity
messages: Belongs to the TVP38/TMEM64 family.
messages: Golgi membrane protein involved in vesicular trafficking and spindle migration.

45286:AW171 hschr31648
gene id: 45286:AW171_hschr31648
uniprot id: A0A109UWD7
names: Similarity
messages: Belongs to the PPase family.

45286:AW171 hschr31611
gene id: 45286:AW171_hschr31611
uniprot id: A0A109UYD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-3 family.
messages: Membrane
messages: Peroxisome membrane

45286:AW171 hschr42304
gene id: 45286:AW171_hschr42304
uniprot id: A0A0X8HR05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

45286:AW171 hschr31846
gene id: 45286:AW171_hschr31846
uniprot id: A0A0X8HR89
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

45286:AW171 hschr74225
gene id: 45286:AW171_hschr74225
uniprot id: A0A109UY30
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
messages: Mitochondrion matrix
messages: Monomer.

45286:AW171 hschr31909
gene id: 45286:AW171_hschr31909
uniprot id: A0A0X8HRD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.
messages: Cytoplasm

45286:AW171 hschr53324
gene id: 45286:AW171_hschr53324
uniprot id: A0A0X8HTV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP72 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
messages: Cytoplasm

45286:AW171 hschr63838
gene id: 45286:AW171_hschr63838
uniprot id: A0A120K2K7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates elongation factor 1-alpha at 'Lys-79'.

45286:AW171 hschr84905
gene id: 45286:AW171_hschr84905
uniprot id: A0A120K2X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

45286:AW171 hschr53100
gene id: 45286:AW171_hschr53100
uniprot id: A0A109UZD3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space

45286:AW171 hschr84983
gene id: 45286:AW171_hschr84983
uniprot id: A0A109V0G4
names: Similarity
messages: Belongs to the ISF1/MBR1 family.

45286:AW171 hschr63701
gene id: 45286:AW171_hschr63701
uniprot id: A0A0X8HUI8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
messages: Heterodimer of an alpha and a beta subunit.

45286:AW171 hschr31817
gene id: 45286:AW171_hschr31817
uniprot id: A0A109UYJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LOT5 family.
messages: Nucleus

45286:AW171 hschr31535
gene id: 45286:AW171_hschr31535
uniprot id: A0A109UY81
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

45286:AW171 hschr2345
gene id: 45286:AW171_hschr2345
uniprot id: A0A120K0Y5
names: Similarity
messages: Belongs to the protein kinase superfamily.

45286:AW171 hschr31968
gene id: 45286:AW171_hschr31968
uniprot id: A0A109UYM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.
messages: Membrane
messages: Vacuole membrane

45286:AW171 hschr2180
gene id: 45286:AW171_hschr2180
uniprot id: A0A109UWA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

45286:AW171 hschr2390
gene id: 45286:AW171_hschr2390
uniprot id: A0A109UWJ7
names: Similarity
messages: Belongs to the peptidase M18 family.

45286:AW171 hschr42389
gene id: 45286:AW171_hschr42389
uniprot id: A0A0X8HS87
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr53048
gene id: 45286:AW171_hschr53048
uniprot id: A0A0X8HTC5
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

45286:AW171 hschr42159
gene id: 45286:AW171_hschr42159
uniprot id: A0A0X8HRT3
names: Similarity
messages: Belongs to the cullin family.

45286:AW171 hschr74292
gene id: 45286:AW171_hschr74292
uniprot id: A0A0X8HVG8
names: Function
names: Similarity
messages: 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

45286:AW171 hschr53054
gene id: 45286:AW171_hschr53054
uniprot id: A0A109UXC5
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.

45286:AW171 hschr42608
gene id: 45286:AW171_hschr42608
uniprot id: A0A109UZ43
names: Similarity
messages: Belongs to the cyclin family.

45286:AW171 hschr2364
gene id: 45286:AW171_hschr2364
uniprot id: A0A120K0Z3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nth/MutY family.
messages: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
messages: Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.
messages: Mitochondrion
messages: Nucleus

45286:AW171 hschr294
gene id: 45286:AW171_hschr294
uniprot id: A0A120K0R6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

45286:AW171 hschr74013
gene id: 45286:AW171_hschr74013
uniprot id: A0A0X8HV15
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family.
messages: Heterodimer.

45286:AW171 hschr31541
gene id: 45286:AW171_hschr31541
uniprot id: A0A109UY48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Vacuole membrane

45286:AW171 hschr42117
gene id: 45286:AW171_hschr42117
uniprot id: A0A0X8HRR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

45286:AW171 hschr63981
gene id: 45286:AW171_hschr63981
uniprot id: A0A0X8HUX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Membrane
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.

45286:AW171 hschr74074
gene id: 45286:AW171_hschr74074
uniprot id: A0A0X8HV35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIF1/spd1 family.
messages: Cytoplasm
messages: Nucleus

45286:AW171 hschr53157
gene id: 45286:AW171_hschr53157
uniprot id: A0A0X8HTL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

45286:AW171 hschr31317
gene id: 45286:AW171_hschr31317
uniprot id: A0A109UVT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGX family.
messages: Endoplasmic reticulum membrane
messages: Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.

45286:AW171 hschr42319
gene id: 45286:AW171_hschr42319
uniprot id: A0A0X8HR20
names: Similarity
messages: Belongs to the peptidase M20A family.

45286:AW171 hschr84695
gene id: 45286:AW171_hschr84695
uniprot id: A0A0X8HWC6
names: Similarity
messages: Belongs to the RICTOR family.

45286:AW171 hschr63687
gene id: 45286:AW171_hschr63687
uniprot id: A0A0X8HUH2
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.

45286:AW171 hschr31631
gene id: 45286:AW171_hschr31631
uniprot id: A0A109UWC8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

45286:AW171 hschr31640
gene id: 45286:AW171_hschr31640
uniprot id: A0A109UYA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

45286:AW171 hschr2990
gene id: 45286:AW171_hschr2990
uniprot id: A0A125RE19
names: Function
names: Similarity
messages: Belongs to the BLOC1S4 family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting.

45286:AW171 hschr21134
gene id: 45286:AW171_hschr21134
uniprot id: A0A120K1E5
names: Similarity
messages: Belongs to the SecY/SEC61-alpha family.

45286:AW171 hschr74072
gene id: 45286:AW171_hschr74072
uniprot id: A0A0X8HV70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chitin synthase family.
messages: Cell membrane
messages: Membrane
messages: Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.

45286:AW171 hschr63845
gene id: 45286:AW171_hschr63845
uniprot id: A0A120K2K8
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.

45286:AW171 hschr2954
gene id: 45286:AW171_hschr2954
uniprot id: A0A120K1A2
names: Caution
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anamorsin family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion intermembrane space
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

45286:AW171 hschr2470
gene id: 45286:AW171_hschr2470
uniprot id: A0A109UX51
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: In the 2nd section; belongs to the EPSP synthase family.
messages: In the 2nd section; belongs to the type-I 3-dehydroquinase family.
messages: In the 3rd section; belongs to the shikimate kinase family.
messages: In the 4th section; belongs to the type-I 3-dehydroquinase family.
messages: In the C-terminal section; belongs to the shikimate dehydrogenase family.
messages: In the N-terminal section; belongs to the dehydroquinate synthase family.
messages: In the N-terminal section; belongs to the shikimate kinase family.
messages: In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.

45286:AW171 hschr52933
gene id: 45286:AW171_hschr52933
uniprot id: A0A120K2B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr84914
gene id: 45286:AW171_hschr84914
uniprot id: A0A0X8HWP2
names: Function
names: Similarity
messages: Belongs to the REXO4 family.
messages: Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.

45286:AW171 hschr74443
gene id: 45286:AW171_hschr74443
uniprot id: A0A0X8HVU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

45286:AW171 hschr42345
gene id: 45286:AW171_hschr42345
uniprot id: A0A0X8HS19
names: Function
names: Subcellular Location Annotation
messages: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr31315
gene id: 45286:AW171_hschr31315
uniprot id: A0A109UXW4
names: Similarity
messages: Belongs to the MT-A70-like family.

45286:AW171 hschr63859
gene id: 45286:AW171_hschr63859
uniprot id: A0A109UXU7
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

45286:AW171 hschr84655
gene id: 45286:AW171_hschr84655
uniprot id: A0A109V099
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

45286:AW171 hschr53063
gene id: 45286:AW171_hschr53063
uniprot id: A0A0X8HTD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

45286:AW171 hschr63502
gene id: 45286:AW171_hschr63502
uniprot id: A0A0X8HU37
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

45286:AW171 hschr42525
gene id: 45286:AW171_hschr42525
uniprot id: A0A0X8HSF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: P-body

45286:AW171 hschr53202
gene id: 45286:AW171_hschr53202
uniprot id: A0A0X8HSY4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleus

45286:AW171 hschr63603
gene id: 45286:AW171_hschr63603
uniprot id: A0A0X8HUD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGS family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr42156
gene id: 45286:AW171_hschr42156
uniprot id: A0A0X8HRV0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

45286:AW171 hschr63835
gene id: 45286:AW171_hschr63835
uniprot id: A0A0X8HUT3
names: Function
names: Similarity
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.

45286:AW171 hschr31649
gene id: 45286:AW171_hschr31649
uniprot id: A0A109UYD4
names: Similarity
messages: Belongs to the TrpF family.

45286:AW171 hschr42366
gene id: 45286:AW171_hschr42366
uniprot id: A0A109UYS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
messages: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.
messages: Mitochondrion outer membrane

45286:AW171 hschr2434
gene id: 45286:AW171_hschr2434
uniprot id: A0A109UXF0
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr31583
gene id: 45286:AW171_hschr31583
uniprot id: A0A109UYD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: Interacts with TAN1.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
messages: nucleolus

45286:AW171 hschr84918
gene id: 45286:AW171_hschr84918
uniprot id: A0A0X8HWL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm

45286:AW171 hschr74374
gene id: 45286:AW171_hschr74374
uniprot id: A0A0X8HVL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: nuclear pore complex

45286:AW171 hschr84922
gene id: 45286:AW171_hschr84922
uniprot id: A0A109V139
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

45286:AW171 hschr31663
gene id: 45286:AW171_hschr31663
uniprot id: A0A109UWE7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLX1 family.
messages: Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
messages: Forms a heterodimer with SLX4.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

45286:AW171 hschr74331
gene id: 45286:AW171_hschr74331
uniprot id: A0A0X8HVJ3
names: Function
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.

45286:AW171 hschr31394
gene id: 45286:AW171_hschr31394
uniprot id: A0A109UXV6
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr21231
gene id: 45286:AW171_hschr21231
uniprot id: A0A109UYC5
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

45286:AW171 hschr85019
gene id: 45286:AW171_hschr85019
uniprot id: A0A109V0G3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CGI121/TPRKB family.
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification.

45286:AW171 hschr84680
gene id: 45286:AW171_hschr84680
uniprot id: A0A0X8HWC2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS8 family.

45286:AW171 hschr84828
gene id: 45286:AW171_hschr84828
uniprot id: A0A120K2W3
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

45286:AW171 hschr31385
gene id: 45286:AW171_hschr31385
uniprot id: A0A120K1N1
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

45286:AW171 hschr53436
gene id: 45286:AW171_hschr53436
uniprot id: A0A0X8HU40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CGR1 family.
messages: Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.
messages: nucleolus

45286:AW171 hschr42478
gene id: 45286:AW171_hschr42478
uniprot id: A0A109UYY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

45286:AW171 hschr31606
gene id: 45286:AW171_hschr31606
uniprot id: A0A120K1U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND3 (condensin subunit 3) family.
messages: Chromosome

45286:AW171 hschr31797
gene id: 45286:AW171_hschr31797
uniprot id: A0A0X8HR63
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr52916
gene id: 45286:AW171_hschr52916
uniprot id: A0A109UX95
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

45286:AW171 hschr84874
gene id: 45286:AW171_hschr84874
uniprot id: A0A120K2W6
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

45286:AW171 hschr84801
gene id: 45286:AW171_hschr84801
uniprot id: A0A0X8HWK6
names: Similarity
messages: Belongs to the AAA ATPase family.

45286:AW171 hschr52937
gene id: 45286:AW171_hschr52937
uniprot id: A0A0X8HT66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr53333
gene id: 45286:AW171_hschr53333
uniprot id: A0A0X8HU01
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr84685
gene id: 45286:AW171_hschr84685
uniprot id: A0A0X8HW54
names: Similarity
messages: Belongs to the peptidase C19 family.

45286:AW171 hschr42829
gene id: 45286:AW171_hschr42829
uniprot id: A0A0X8HT01
names: Similarity
messages: Belongs to the sulfiredoxin family.

45286:AW171 hschr31676
gene id: 45286:AW171_hschr31676
uniprot id: A0A109UYJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

45286:AW171 hschr42617
gene id: 45286:AW171_hschr42617
uniprot id: A0A0X8HSK9
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

45286:AW171 hschr53390
gene id: 45286:AW171_hschr53390
uniprot id: A0A0X8HU12
names: Function
names: Similarity
messages: Belongs to the cyclin family.
messages: G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition.

45286:AW171 hschr63601
gene id: 45286:AW171_hschr63601
uniprot id: A0A0X8HUH7
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

45286:AW171 hschr74386
gene id: 45286:AW171_hschr74386
uniprot id: A0A120K2R5
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

45286:AW171 hschr52905
gene id: 45286:AW171_hschr52905
uniprot id: A0A0X8HT47
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

45286:AW171 hschr84586
gene id: 45286:AW171_hschr84586
uniprot id: A0A0X8HVZ8
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

45286:AW171 hschr21040
gene id: 45286:AW171_hschr21040
uniprot id: A0A109UXB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS41 family.
messages: Mitochondrion

45286:AW171 hschr2409
gene id: 45286:AW171_hschr2409
uniprot id: A0A120K118
names: Similarity
messages: Belongs to the RNase H family.

45286:AW171 hschr42391
gene id: 45286:AW171_hschr42391
uniprot id: A0A0X8HSB7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

45286:AW171 hschr84724
gene id: 45286:AW171_hschr84724
uniprot id: A0A0X8HWF8
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

45286:AW171 hschr53437
gene id: 45286:AW171_hschr53437
uniprot id: A0A0X8HU64
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myo-inositol oxygenase family.
messages: Binds 2 iron ions per subunit.
messages: Cytoplasm

45286:AW171 hschr42074
gene id: 45286:AW171_hschr42074
uniprot id: A0A120K225
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.

45286:AW171 hschr84878
gene id: 45286:AW171_hschr84878
uniprot id: A0A0X8HWK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: Cytoplasm
messages: nucleolus

45286:AW171 hschr31419
gene id: 45286:AW171_hschr31419
uniprot id: A0A109UY05
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

45286:AW171 hschr21058
gene id: 45286:AW171_hschr21058
uniprot id: A0A109UXA2
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

45286:AW171 hschr53106
gene id: 45286:AW171_hschr53106
uniprot id: A0A0X8HTL0
names: Similarity
messages: Belongs to the threonine aldolase family.

45286:AW171 hschr52882
gene id: 45286:AW171_hschr52882
uniprot id: A0A109UZ76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

45286:AW171 hschr53167
gene id: 45286:AW171_hschr53167
uniprot id: A0A0X8HTH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr42473
gene id: 45286:AW171_hschr42473
uniprot id: A0A0X8HRC9
names: Similarity
messages: Belongs to the glutaminase PdxT/SNO family.

45286:AW171 hschr26
gene id: 45286:AW171_hschr26
uniprot id: A0A109UVZ2
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

45286:AW171 hschr31570
gene id: 45286:AW171_hschr31570
uniprot id: A0A109UW88
names: Similarity
messages: Belongs to the peptidase S1C family.

45286:AW171 hschr2506
gene id: 45286:AW171_hschr2506
uniprot id: A0A120K140
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Nucleus

45286:AW171 hschr52894
gene id: 45286:AW171_hschr52894
uniprot id: A0A0X8HT30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IML1 family.
messages: Membrane
messages: Vacuole membrane

45286:AW171 hschr231
gene id: 45286:AW171_hschr231
uniprot id: A0A109UVV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

45286:AW171 hschr21096
gene id: 45286:AW171_hschr21096
uniprot id: A0A120K1D7
names: Similarity
messages: Belongs to the helicase family. SKI2 subfamily.

45286:AW171 hschr31668
gene id: 45286:AW171_hschr31668
uniprot id: A0A120K1W4
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr63829
gene id: 45286:AW171_hschr63829
uniprot id: A0A0X8HUP0
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr63584
gene id: 45286:AW171_hschr63584
uniprot id: A0A0X8HUC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP6 family.
messages: nucleolus

45286:AW171 hschr31926
gene id: 45286:AW171_hschr31926
uniprot id: A0A120K207
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

45286:AW171 hschr42559
gene id: 45286:AW171_hschr42559
uniprot id: A0A109UZ31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tim44 family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion inner membrane

45286:AW171 hschr63534
gene id: 45286:AW171_hschr63534
uniprot id: A0A0X8HUC0
names: Similarity
messages: Belongs to the activator 1 small subunits family.

45286:AW171 hschr42662
gene id: 45286:AW171_hschr42662
uniprot id: A0A0X8HSQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMA20 family.
messages: Cytoplasm
messages: Involved in translation.

45286:AW171 hschr53253
gene id: 45286:AW171_hschr53253
uniprot id: A0A0X8HTS5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HDDC2 family.
messages: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
messages: Homodimer.

45286:AW171 hschr42462
gene id: 45286:AW171_hschr42462
uniprot id: A0A109UWZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-22 family.
messages: Involved in peroxisome biogenesis.
messages: Membrane
messages: Peroxisome membrane

45286:AW171 hschr84790
gene id: 45286:AW171_hschr84790
uniprot id: A0A0X8HWG4
names: Similarity
messages: Belongs to the NUP186/NUP192/NUP205 family.

45286:AW171 hschr21030
gene id: 45286:AW171_hschr21030
uniprot id: A0A120K1B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AATF family.
messages: nucleolus

45286:AW171 hschr52987
gene id: 45286:AW171_hschr52987
uniprot id: A0A0X8HTB1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm
messages: Mitochondrion
messages: Monomer.

45286:AW171 hschr63763
gene id: 45286:AW171_hschr63763
uniprot id: A0A0X8HUM7
names: Similarity
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.

45286:AW171 hschr31448
gene id: 45286:AW171_hschr31448
uniprot id: A0A109UXZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

45286:AW171 hschr42555
gene id: 45286:AW171_hschr42555
uniprot id: A0A0X8HSH6
names: Similarity
messages: Belongs to the TPA1 family.

45286:AW171 hschr53200
gene id: 45286:AW171_hschr53200
uniprot id: A0A0X8HTM8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.

45286:AW171 hschr42832
gene id: 45286:AW171_hschr42832
uniprot id: A0A120K2A6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

45286:AW171 hschr63915
gene id: 45286:AW171_hschr63915
uniprot id: A0A0X8HUV8
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

45286:AW171 hschr2420
gene id: 45286:AW171_hschr2420
uniprot id: A0A109UX25
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr31758
gene id: 45286:AW171_hschr31758
uniprot id: A0A0X8HR38
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

45286:AW171 hschr63655
gene id: 45286:AW171_hschr63655
uniprot id: A0A0X8HTS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

45286:AW171 hschr31566
gene id: 45286:AW171_hschr31566
uniprot id: A0A109UW89
names: Subcellular Location Annotation
messages: Mitochondrion intermembrane space

45286:AW171 hschr63931
gene id: 45286:AW171_hschr63931
uniprot id: A0A0X8HUW7
names: Similarity
messages: Belongs to the MAPRE family.

45286:AW171 hschr84553
gene id: 45286:AW171_hschr84553
uniprot id: A0A0X8HW53
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
messages: Membrane

45286:AW171 hschr63989
gene id: 45286:AW171_hschr63989
uniprot id: A0A120K2M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

45286:AW171 hschr84988
gene id: 45286:AW171_hschr84988
uniprot id: A0A0X8HWS5
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

45286:AW171 hschr31386
gene id: 45286:AW171_hschr31386
uniprot id: A0A109UXV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Mitochondrion inner membrane

45286:AW171 hschr2872
gene id: 45286:AW171_hschr2872
uniprot id: A0A109UXD7
names: Similarity
messages: Belongs to the SF3A2 family.

45286:AW171 hschr53055
gene id: 45286:AW171_hschr53055
uniprot id: A0A109UZC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.
messages: Nucleus

45286:AW171 hschr42197
gene id: 45286:AW171_hschr42197
uniprot id: A0A109UYS7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family. SCS7 subfamily.
messages: Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.
messages: Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr2140
gene id: 45286:AW171_hschr2140
uniprot id: A0A120K0T1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

45286:AW171 hschr42252
gene id: 45286:AW171_hschr42252
uniprot id: A0A0X8HS24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr31608
gene id: 45286:AW171_hschr31608
uniprot id: A0A120K1V0
names: Similarity
messages: Belongs to the SWI5/SAE3 family.

45286:AW171 hschr42167
gene id: 45286:AW171_hschr42167
uniprot id: A0A120K233
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF8 family.
messages: Nucleus

45286:AW171 hschr2958
gene id: 45286:AW171_hschr2958
uniprot id: A0A109UX67
names: Similarity
messages: Belongs to the ETT1 family.

45286:AW171 hschr74383
gene id: 45286:AW171_hschr74383
uniprot id: A0A0X8HVM5
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr31976
gene id: 45286:AW171_hschr31976
uniprot id: A0A0X8HRI2
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

45286:AW171 hschr84927
gene id: 45286:AW171_hschr84927
uniprot id: A0A0X8HWT6
names: Function
names: Similarity
messages: Belongs to the HTP reductase family.
messages: Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.

45286:AW171 hschr84913
gene id: 45286:AW171_hschr84913
uniprot id: A0A0X8HWR0
names: Similarity
messages: Belongs to the SIN1 family.

45286:AW171 hschr84834
gene id: 45286:AW171_hschr84834
uniprot id: A0A0X8HWG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX16 family.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr42201
gene id: 45286:AW171_hschr42201
uniprot id: A0A0X8HRV1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

45286:AW171 hschr84911
gene id: 45286:AW171_hschr84911
uniprot id: A0A0X8HWK8
names: Similarity
messages: Belongs to the MDM20/NAA25 family.

45286:AW171 hschr42773
gene id: 45286:AW171_hschr42773
uniprot id: A0A0X8HSX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex ASK1 family.
messages: Nucleus
messages: kinetochore
messages: spindle

45286:AW171 hschr84832
gene id: 45286:AW171_hschr84832
uniprot id: A0A0X8HWH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

45286:AW171 hschr53043
gene id: 45286:AW171_hschr53043
uniprot id: A0A0X8HTG0
names: Function
names: Similarity
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.

45286:AW171 hschr42474
gene id: 45286:AW171_hschr42474
uniprot id: A0A0X8HSC7
names: Similarity
messages: Belongs to the PdxS/SNZ family.

45286:AW171 hschr31462
gene id: 45286:AW171_hschr31462
uniprot id: A0A120K1R4
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.

45286:AW171 hschr42557
gene id: 45286:AW171_hschr42557
uniprot id: A0A0X8HSH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

45286:AW171 hschr21255
gene id: 45286:AW171_hschr21255
uniprot id: A0A120K1I6
names: Similarity
messages: Belongs to the importin alpha family.

45286:AW171 hschr31919
gene id: 45286:AW171_hschr31919
uniprot id: A0A0X8HRE3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

45286:AW171 hschr42752
gene id: 45286:AW171_hschr42752
uniprot id: A0A0X8HSU3
names: Similarity
messages: Belongs to the transglutaminase-like superfamily. PNGase family.

45286:AW171 hschr74410
gene id: 45286:AW171_hschr74410
uniprot id: A0A0X8HVR4
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

45286:AW171 hschr42691
gene id: 45286:AW171_hschr42691
uniprot id: A0A120K290
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INCENP family.
messages: Nucleus
messages: spindle

45286:AW171 hschr42259
gene id: 45286:AW171_hschr42259
uniprot id: A0A0X8HRX4
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr84822
gene id: 45286:AW171_hschr84822
uniprot id: A0A109V0C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Vacuole membrane

45286:AW171 hschr2982
gene id: 45286:AW171_hschr2982
uniprot id: A0A109UX56
names: Subcellular Location Annotation
messages: Golgi apparatus

45286:AW171 hschr2871
gene id: 45286:AW171_hschr2871
uniprot id: A0A109UWX0
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.

45286:AW171 hschr2334
gene id: 45286:AW171_hschr2334
uniprot id: A0A109UWE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLX9 family.
messages: Interacts with the 35S, 23S and 20S pre-rRNAs and with the U3 snoRNA.
messages: Involved in ribosome biogenesis. Required for normal pre-rRNA processing in internal transcribed spacer 1 (ITS1). May be involved in the movements of the replication forks.
messages: nucleolus

45286:AW171 hschr42155
gene id: 45286:AW171_hschr42155
uniprot id: A0A0X8HRT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF beta subunit family.
messages: Nucleus

45286:AW171 hschr2538
gene id: 45286:AW171_hschr2538
uniprot id: A0A120K148
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF10 family.
messages: Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation), facilitation of DNA opening and initiation of transcription. SAGA is required for recruitment of the basal transcription machinery. SLIK is proposed to have partly overlapping functions with SAGA.
messages: Nucleus

45286:AW171 hschr63483
gene id: 45286:AW171_hschr63483
uniprot id: A0A109UZY9
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

45286:AW171 hschr63674
gene id: 45286:AW171_hschr63674
uniprot id: A0A0X8HUF4
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

45286:AW171 hschr31680
gene id: 45286:AW171_hschr31680
uniprot id: A0A109UYU0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Expected to bind 2 Fe(2+) ions per subunit.
messages: Membrane
messages: Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.

45286:AW171 hschr42770
gene id: 45286:AW171_hschr42770
uniprot id: A0A109UZ62
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

45286:AW171 hschr53224
gene id: 45286:AW171_hschr53224
uniprot id: A0A0X8HTP9
names: Similarity
messages: Belongs to the UPP synthase family.

45286:AW171 hschr52977
gene id: 45286:AW171_hschr52977
uniprot id: A0A0X8HT77
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr85033
gene id: 45286:AW171_hschr85033
uniprot id: A0A0X8HWW4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

45286:AW171 hschr74339
gene id: 45286:AW171_hschr74339
uniprot id: A0A0X8HVJ2
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

45286:AW171 hschr31719
gene id: 45286:AW171_hschr31719
uniprot id: A0A109UYB9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

45286:AW171 hschr286
gene id: 45286:AW171_hschr286
uniprot id: A0A109UW29
names: Function
names: Similarity
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.

45286:AW171 hschr63741
gene id: 45286:AW171_hschr63741
uniprot id: A0A0X8HUK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

45286:AW171 hschr2923
gene id: 45286:AW171_hschr2923
uniprot id: A0A120K186
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

45286:AW171 hschr2382
gene id: 45286:AW171_hschr2382
uniprot id: A0A109UWL5
names: Subcellular Location Annotation
messages: nucleolus

45286:AW171 hschr2916
gene id: 45286:AW171_hschr2916
uniprot id: A0A125RE10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ASF1 family.
messages: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.
messages: Interacts with histone H3.
messages: Nucleus

45286:AW171 hschr63551
gene id: 45286:AW171_hschr63551
uniprot id: A0A0X8HUA8
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr2993
gene id: 45286:AW171_hschr2993
uniprot id: A0A109UX87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCP1 family.
messages: Involved in nuclear export, actin cytoskeleton organization and vesicular transport.
messages: Nucleus

45286:AW171 hschr2247
gene id: 45286:AW171_hschr2247
uniprot id: A0A109UW91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
messages: Belongs to the adaptor complexes large subunit family.
messages: coated pit

45286:AW171 hschr84723
gene id: 45286:AW171_hschr84723
uniprot id: A0A0X8HW84
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

45286:AW171 hschr74006
gene id: 45286:AW171_hschr74006
uniprot id: A0A109UZT8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

45286:AW171 hschr53422
gene id: 45286:AW171_hschr53422
uniprot id: A0A0X8HU36
names: Similarity
messages: Belongs to the WD repeat PWP2 family.

45286:AW171 hschr42775
gene id: 45286:AW171_hschr42775
uniprot id: A0A0X8HST3
names: Similarity
messages: Belongs to the EIS1 family.

45286:AW171 hschr63779
gene id: 45286:AW171_hschr63779
uniprot id: A0A0X8HUN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

45286:AW171 hschr53241
gene id: 45286:AW171_hschr53241
uniprot id: A0A0X8HTR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: actin patch

45286:AW171 hschr2243
gene id: 45286:AW171_hschr2243
uniprot id: A0A109UX21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLASP family.
messages: spindle

45286:AW171 hschr42231
gene id: 45286:AW171_hschr42231
uniprot id: A0A109UWU6
names: Similarity
messages: Belongs to the glycosyltransferase 34 family.

45286:AW171 hschr2224
gene id: 45286:AW171_hschr2224
uniprot id: A0A120K0U7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

45286:AW171 hschr21160
gene id: 45286:AW171_hschr21160
uniprot id: A0A109UXH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EXO70 family.
messages: Bud
messages: Bud neck
messages: Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst.

45286:AW171 hschr63580
gene id: 45286:AW171_hschr63580
uniprot id: A0A109UZP2
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

45286:AW171 hschr42447
gene id: 45286:AW171_hschr42447
uniprot id: A0A120K265
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VTS1 family.
messages: Monomer. Binds to RNA.
messages: P-body
messages: cytosol

45286:AW171 hschr63494
gene id: 45286:AW171_hschr63494
uniprot id: A0A0X8HU51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

45286:AW171 hschr63938
gene id: 45286:AW171_hschr63938
uniprot id: A0A0X8HU94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT6 family.
messages: Nucleus
messages: Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression.

45286:AW171 hschr84772
gene id: 45286:AW171_hschr84772
uniprot id: A0A0X8HWF1
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr2251
gene id: 45286:AW171_hschr2251
uniprot id: A0A120K0V9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion
messages: NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.

45286:AW171 hschr2885
gene id: 45286:AW171_hschr2885
uniprot id: A0A125RE06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: Nucleus
messages: Required for pre-mRNA splicing.

45286:AW171 hschr84502
gene id: 45286:AW171_hschr84502
uniprot id: A0A0X8HW23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

45286:AW171 hschr53108
gene id: 45286:AW171_hschr53108
uniprot id: A0A0X8HTG4
names: Similarity
messages: Belongs to the putative lipase ROG1 family.

45286:AW171 hschr63752
gene id: 45286:AW171_hschr63752
uniprot id: A0A0X8HUJ6
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

45286:AW171 hschr2518
gene id: 45286:AW171_hschr2518
uniprot id: A0A109UX83
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Homodimer.

45286:AW171 hschr74031
gene id: 45286:AW171_hschr74031
uniprot id: A0A109V098
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.

45286:AW171 hschr74062
gene id: 45286:AW171_hschr74062
uniprot id: A0A0X8HV41
names: Similarity
messages: Belongs to the CDC6/cdc18 family.

45286:AW171 hschr31844
gene id: 45286:AW171_hschr31844
uniprot id: A0A0X8HR96
names: Similarity
messages: Belongs to the SEC6 family.

45286:AW171 hschr84744
gene id: 45286:AW171_hschr84744
uniprot id: A0A109V0K4
names: Similarity
messages: Belongs to the pyridoxine kinase family.

45286:AW171 hschr63962
gene id: 45286:AW171_hschr63962
uniprot id: A0A109V0J1
names: Similarity
messages: Belongs to the REXO1/REXO3 family.

45286:AW171 hschr42676
gene id: 45286:AW171_hschr42676
uniprot id: A0A109UZ41
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr74388
gene id: 45286:AW171_hschr74388
uniprot id: A0A0X8HVP2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
messages: Homooctamer.

45286:AW171 hschr53312
gene id: 45286:AW171_hschr53312
uniprot id: A0A120K2F7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

45286:AW171 hschr42140
gene id: 45286:AW171_hschr42140
uniprot id: A0A0X8HRR9
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.

45286:AW171 hschr31596
gene id: 45286:AW171_hschr31596
uniprot id: A0A109UYC7
names: Similarity
messages: In the C-terminal section; belongs to the NAD synthetase family.

45286:AW171 hschr63493
gene id: 45286:AW171_hschr63493
uniprot id: A0A109UZL2
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

45286:AW171 hschr42187
gene id: 45286:AW171_hschr42187
uniprot id: A0A0X8HRW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

45286:AW171 hschr31446
gene id: 45286:AW171_hschr31446
uniprot id: A0A120K1Q9
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase class-II family.

45286:AW171 hschr53412
gene id: 45286:AW171_hschr53412
uniprot id: A0A0X8HTD2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.

45286:AW171 hschr21088
gene id: 45286:AW171_hschr21088
uniprot id: A0A125RE31
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS2/PSF2 family.
messages: Component of the GINS complex.
messages: Nucleus

45286:AW171 hschr52991
gene id: 45286:AW171_hschr52991
uniprot id: A0A109UZ73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mis12 family.
messages: kinetochore

45286:AW171 hschr2306
gene id: 45286:AW171_hschr2306
uniprot id: A0A109UWG6
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.

45286:AW171 hschr63704
gene id: 45286:AW171_hschr63704
uniprot id: A0A109UZM1
names: Subcellular Location Annotation
messages: nuclear pore complex

45286:AW171 hschr31870
gene id: 45286:AW171_hschr31870
uniprot id: A0A0X8HRA2
names: Function
names: Similarity
messages: Belongs to the ATP phosphoribosyltransferase family.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of the enzymatic activity.

45286:AW171 hschr53212
gene id: 45286:AW171_hschr53212
uniprot id: A0A0X8HTQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

45286:AW171 hschr74096
gene id: 45286:AW171_hschr74096
uniprot id: A0A0X8HV48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

45286:AW171 hschr84709
gene id: 45286:AW171_hschr84709
uniprot id: A0A0X8HWE7
names: Similarity
messages: Belongs to the RMD1/sif2 family.

45286:AW171 hschr42747
gene id: 45286:AW171_hschr42747
uniprot id: A0A0X8HSV9
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr84895
gene id: 45286:AW171_hschr84895
uniprot id: A0A0X8HWK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DSS1/SEM1 family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Nucleus

45286:AW171 hschr31308
gene id: 45286:AW171_hschr31308
uniprot id: A0A120K1K5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

45286:AW171 hschr42217
gene id: 45286:AW171_hschr42217
uniprot id: A0A0X8HRY0
names: Similarity
messages: Belongs to the activator 1 small subunits family.

45286:AW171 hschr42736
gene id: 45286:AW171_hschr42736
uniprot id: A0A0X8HST2
names: Similarity
messages: Belongs to the AAA ATPase family. PCH2 subfamily.

45286:AW171 hschr2256
gene id: 45286:AW171_hschr2256
uniprot id: A0A109UWC4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

45286:AW171 hschr42845
gene id: 45286:AW171_hschr42845
uniprot id: A0A109UZ38
names: Similarity
messages: Belongs to the DNA2/NAM7 helicase family.

45286:AW171 hschr2158
gene id: 45286:AW171_hschr2158
uniprot id: A0A109UW31
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

45286:AW171 hschr63740
gene id: 45286:AW171_hschr63740
uniprot id: A0A120K2J6
names: Similarity
messages: Belongs to the MYST (SAS/MOZ) family.

45286:AW171 hschr53410
gene id: 45286:AW171_hschr53410
uniprot id: A0A0X8HU26
names: Similarity
messages: Belongs to the peptidase S8 family.

45286:AW171 hschr53242
gene id: 45286:AW171_hschr53242
uniprot id: A0A109UZM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSA1 family.
messages: Component of the pre-66S ribosomal particle.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

45286:AW171 hschr63972
gene id: 45286:AW171_hschr63972
uniprot id: A0A109V041
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily.

45286:AW171 hschr2450
gene id: 45286:AW171_hschr2450
uniprot id: A0A109UXF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GEP5 family.
messages: Essential for respiratory growth and required for maintenance of mtDNA. Required for cell survival in the absence of prohibitins.
messages: Mitochondrion

45286:AW171 hschr63681
gene id: 45286:AW171_hschr63681
uniprot id: A0A0X8HUH4
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr2210
gene id: 45286:AW171_hschr2210
uniprot id: A0A109UX00
names: Similarity
messages: Belongs to the AP endonuclease 2 family.

45286:AW171 hschr31796
gene id: 45286:AW171_hschr31796
uniprot id: A0A109UYE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. SKI2 subfamily.
messages: Cytoplasm

45286:AW171 hschr63585
gene id: 45286:AW171_hschr63585
uniprot id: A0A0X8HU87
names: Function
names: Subcellular Location Annotation
messages: Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation.
messages: Nucleus

45286:AW171 hschr63520
gene id: 45286:AW171_hschr63520
uniprot id: A0A0X8HU46
names: Similarity
messages: Belongs to the glycosyltransferase 32 family.

45286:AW171 hschr2888
gene id: 45286:AW171_hschr2888
uniprot id: A0A109UWZ1
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr52998
gene id: 45286:AW171_hschr52998
uniprot id: A0A0X8HTD0
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

45286:AW171 hschr31411
gene id: 45286:AW171_hschr31411
uniprot id: A0A109UZD5
names: Similarity
messages: Belongs to the SUI1 family.

45286:AW171 hschr74172
gene id: 45286:AW171_hschr74172
uniprot id: A0A0X8HVC6
names: Similarity
messages: Belongs to the peptidase M28 family.

45286:AW171 hschr42561
gene id: 45286:AW171_hschr42561
uniprot id: A0A109UZP9
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

45286:AW171 hschr52890
gene id: 45286:AW171_hschr52890
uniprot id: A0A0X8HT37
names: Similarity
messages: Belongs to the TTI2 family.

45286:AW171 hschr2477
gene id: 45286:AW171_hschr2477
uniprot id: A0A120K122
names: Function
names: Similarity
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.

45286:AW171 hschr2353
gene id: 45286:AW171_hschr2353
uniprot id: A0A125RDX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC5 subfamily.
messages: Nucleus

45286:AW171 hschr74308
gene id: 45286:AW171_hschr74308
uniprot id: A0A0X8HVH0
names: Function
names: Similarity
messages: Belongs to the TFIIE alpha subunit family.
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

45286:AW171 hschr2453
gene id: 45286:AW171_hschr2453
uniprot id: A0A125RDY6
names: Similarity
messages: Belongs to the eIF2D family.

45286:AW171 hschr74282
gene id: 45286:AW171_hschr74282
uniprot id: A0A0X8HVJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

45286:AW171 hschr53229
gene id: 45286:AW171_hschr53229
uniprot id: A0A109UXF6
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

45286:AW171 hschr84531
gene id: 45286:AW171_hschr84531
uniprot id: A0A120K2T0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

45286:AW171 hschr74382
gene id: 45286:AW171_hschr74382
uniprot id: A0A109V054
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr84795
gene id: 45286:AW171_hschr84795
uniprot id: A0A109V0G8
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

45286:AW171 hschr42750
gene id: 45286:AW171_hschr42750
uniprot id: A0A0X8HSV3
names: Subcellular Location Annotation
messages: Mitochondrion outer membrane

45286:AW171 hschr84653
gene id: 45286:AW171_hschr84653
uniprot id: A0A109V0I4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

45286:AW171 hschr42091
gene id: 45286:AW171_hschr42091
uniprot id: A0A109UWS1
names: Function
names: Similarity
messages: Belongs to the phage and mitochondrial RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

45286:AW171 hschr74070
gene id: 45286:AW171_hschr74070
uniprot id: A0A0X8HV49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: Cytoplasm
messages: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
messages: Monomer.

45286:AW171 hschr2308
gene id: 45286:AW171_hschr2308
uniprot id: A0A109UWD2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.

45286:AW171 hschr74302
gene id: 45286:AW171_hschr74302
uniprot id: A0A109V046
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP18 family.
messages: Golgi apparatus membrane
messages: Golgi membrane protein involved in vesicular trafficking.
messages: Membrane

45286:AW171 hschr31636
gene id: 45286:AW171_hschr31636
uniprot id: A0A120K1V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr74239
gene id: 45286:AW171_hschr74239
uniprot id: A0A120K2P7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

45286:AW171 hschr74347
gene id: 45286:AW171_hschr74347
uniprot id: A0A120K2Q9
names: Similarity
messages: Belongs to the peptidase C48 family.

45286:AW171 hschr74441
gene id: 45286:AW171_hschr74441
uniprot id: A0A0X8HVT5
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr52917
gene id: 45286:AW171_hschr52917
uniprot id: A0A109UZ91
names: Similarity
messages: Belongs to the class-I DAHP synthase family.

45286:AW171 hschr21277
gene id: 45286:AW171_hschr21277
uniprot id: A0A109UVR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily.
messages: Homodimer.
messages: Plays an important role in the cellular response to the nitrogen source.

45286:AW171 hschr32017
gene id: 45286:AW171_hschr32017
uniprot id: A0A120K217
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Nucleus

45286:AW171 hschr42812
gene id: 45286:AW171_hschr42812
uniprot id: A0A0X8HS86
names: Function
names: Subcellular Location Annotation
messages: Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
messages: Cytoplasm
messages: Nucleus

45286:AW171 hschr63983
gene id: 45286:AW171_hschr63983
uniprot id: A0A0X8HV45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 17 family.
messages: cell wall

45286:AW171 hschr31434
gene id: 45286:AW171_hschr31434
uniprot id: A0A120K1P2
names: Function
names: Similarity
names: Subunit
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.
messages: Monomer.

45286:AW171 hschr2403
gene id: 45286:AW171_hschr2403
uniprot id: A0A125RDY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

45286:AW171 hschr42494
gene id: 45286:AW171_hschr42494
uniprot id: A0A120K268
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.

45286:AW171 hschr85057
gene id: 45286:AW171_hschr85057
uniprot id: A0A0X8HX15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ING family.
messages: Nucleus

45286:AW171 hschr214
gene id: 45286:AW171_hschr214
uniprot id: A0A120K0P3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).
messages: Nucleus

45286:AW171 hschr31861
gene id: 45286:AW171_hschr31861
uniprot id: A0A109UYR4
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

45286:AW171 hschr42455
gene id: 45286:AW171_hschr42455
uniprot id: A0A0X8HSA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.
messages: Mitochondrion outer membrane

45286:AW171 hschr84600
gene id: 45286:AW171_hschr84600
uniprot id: A0A0X8HW16
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

45286:AW171 hschr63723
gene id: 45286:AW171_hschr63723
uniprot id: A0A109UZS1
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.

45286:AW171 hschr21108
gene id: 45286:AW171_hschr21108
uniprot id: A0A109UVA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the battenin family.
messages: Membrane
messages: Vacuole membrane

45286:AW171 hschr42361
gene id: 45286:AW171_hschr42361
uniprot id: A0A0X8HS97
names: Similarity
messages: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.

45286:AW171 hschr2963
gene id: 45286:AW171_hschr2963
uniprot id: A0A125RE16
names: Similarity
messages: Belongs to the DEAD box helicase family.

45286:AW171 hschr42299
gene id: 45286:AW171_hschr42299
uniprot id: A0A0X8HRY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Membrane

45286:AW171 hschr53136
gene id: 45286:AW171_hschr53136
uniprot id: A0A0X8HTJ6
names: Function
names: Similarity
messages: Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
messages: Belongs to the adaptor complexes large subunit family.

45286:AW171 hschr42616
gene id: 45286:AW171_hschr42616
uniprot id: A0A0X8HSN0
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr21226
gene id: 45286:AW171_hschr21226
uniprot id: A0A120K1H8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CHS7 family.
messages: Chaperone required for the export of the chitin synthase CHS3 from the endoplasmic reticulum.
messages: Interacts with CHS3.
messages: Membrane

45286:AW171 hschr31747
gene id: 45286:AW171_hschr31747
uniprot id: A0A0X8HR32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

45286:AW171 hschr63536
gene id: 45286:AW171_hschr63536
uniprot id: A0A0X8HU56
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.

45286:AW171 hschr74255
gene id: 45286:AW171_hschr74255
uniprot id: A0A109V034
names: Similarity
messages: Belongs to the COG3 family.

45286:AW171 hschr74010
gene id: 45286:AW171_hschr74010
uniprot id: A0A109UZY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: Nucleus
messages: Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex.

45286:AW171 hschr63663
gene id: 45286:AW171_hschr63663
uniprot id: A0A0X8HUG9
names: Similarity
messages: Belongs to the AAA ATPase family.

45286:AW171 hschr31594
gene id: 45286:AW171_hschr31594
uniprot id: A0A109UY74
names: Similarity
messages: Belongs to the OSBP family.

45286:AW171 hschr31619
gene id: 45286:AW171_hschr31619
uniprot id: A0A109UY96
names: Similarity
messages: Belongs to the TCF25 family.

45286:AW171 hschr31581
gene id: 45286:AW171_hschr31581
uniprot id: A0A109UWA0
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

45286:AW171 hschr53206
gene id: 45286:AW171_hschr53206
uniprot id: A0A0X8HTM4
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr42484
gene id: 45286:AW171_hschr42484
uniprot id: A0A0X8HSE9
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr84806
gene id: 45286:AW171_hschr84806
uniprot id: A0A109V0F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

45286:AW171 hschr2837
gene id: 45286:AW171_hschr2837
uniprot id: A0A109UX03
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr2414
gene id: 45286:AW171_hschr2414
uniprot id: A0A125RDY1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS11 family.
messages: Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.
messages: Vacuole membrane

45286:AW171 hschr74268
gene id: 45286:AW171_hschr74268
uniprot id: A0A109V0A2
names: Similarity
messages: Belongs to the RRP1 family.

45286:AW171 hschr63581
gene id: 45286:AW171_hschr63581
uniprot id: A0A109V009
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr21092
gene id: 45286:AW171_hschr21092
uniprot id: A0A125RE32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIM54 family.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr2196
gene id: 45286:AW171_hschr2196
uniprot id: A0A109UW99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

45286:AW171 hschr32015
gene id: 45286:AW171_hschr32015
uniprot id: A0A0X8HRJ0
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

45286:AW171 hschr21196
gene id: 45286:AW171_hschr21196
uniprot id: A0A109UXI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EAF7 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
messages: Nucleus

45286:AW171 hschr63820
gene id: 45286:AW171_hschr63820
uniprot id: A0A109UZU1
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.

45286:AW171 hschr21067
gene id: 45286:AW171_hschr21067
uniprot id: A0A120K1C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

45286:AW171 hschr2219
gene id: 45286:AW171_hschr2219
uniprot id: A0A120K0U5
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Binds 1 pyruvoyl group covalently per subunit.

45286:AW171 hschr2419
gene id: 45286:AW171_hschr2419
uniprot id: A0A109UWK3
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

45286:AW171 hschr63960
gene id: 45286:AW171_hschr63960
uniprot id: A0A109UZX7
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr2359
gene id: 45286:AW171_hschr2359
uniprot id: A0A109UWY3
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.

45286:AW171 hschr42665
gene id: 45286:AW171_hschr42665
uniprot id: A0A0X8HST6
names: Similarity
messages: Belongs to the SEC3 family.

45286:AW171 hschr31757
gene id: 45286:AW171_hschr31757
uniprot id: A0A0X8HR41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Cell membrane
messages: Membrane

45286:AW171 hschr84707
gene id: 45286:AW171_hschr84707
uniprot id: A0A0X8HW86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

45286:AW171 hschr2131
gene id: 45286:AW171_hschr2131
uniprot id: A0A109UWU8
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

45286:AW171 hschr63834
gene id: 45286:AW171_hschr63834
uniprot id: A0A0X8HU33
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

45286:AW171 hschr31359
gene id: 45286:AW171_hschr31359
uniprot id: A0A109UVW4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

45286:AW171 hschr2938
gene id: 45286:AW171_hschr2938
uniprot id: A0A120K197
names: Similarity
messages: Belongs to the AIM23 family.

45286:AW171 hschr84959
gene id: 45286:AW171_hschr84959
uniprot id: A0A0X8HWW6
names: Function
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.

45286:AW171 hschr63762
gene id: 45286:AW171_hschr63762
uniprot id: A0A0X8HUR3
names: Function
names: Similarity
messages: Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
messages: Belongs to the adaptor complexes large subunit family.

45286:AW171 hschr31840
gene id: 45286:AW171_hschr31840
uniprot id: A0A0X8HRA4
names: Similarity
messages: Belongs to the YOS1 family.

45286:AW171 hschr2422
gene id: 45286:AW171_hschr2422
uniprot id: A0A120K111
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr63487
gene id: 45286:AW171_hschr63487
uniprot id: A0A0X8HU28
names: Similarity
messages: Belongs to the actin family.

45286:AW171 hschr42135
gene id: 45286:AW171_hschr42135
uniprot id: A0A120K231
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
messages: Membrane

45286:AW171 hschr74384
gene id: 45286:AW171_hschr74384
uniprot id: A0A120K2R3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.
messages: Nucleus

45286:AW171 hschr31727
gene id: 45286:AW171_hschr31727
uniprot id: A0A109UWI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

45286:AW171 hschr63846
gene id: 45286:AW171_hschr63846
uniprot id: A0A0X8HUR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF5 family.
messages: Nucleus
messages: Part of the chromatin structure-remodeling complex (RSC) which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is essential for mitotic growth and required for cell cycle progression.

45286:AW171 hschr52963
gene id: 45286:AW171_hschr52963
uniprot id: A0A109UZ81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MND1 family.
messages: Nucleus

45286:AW171 hschr31316
gene id: 45286:AW171_hschr31316
uniprot id: A0A109UXT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
messages: nucleolus

45286:AW171 hschr257
gene id: 45286:AW171_hschr257
uniprot id: A0A109UWD0
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr42268
gene id: 45286:AW171_hschr42268
uniprot id: A0A0X8HS03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

45286:AW171 hschr42855
gene id: 45286:AW171_hschr42855
uniprot id: A0A0X8HT55
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

45286:AW171 hschr84851
gene id: 45286:AW171_hschr84851
uniprot id: A0A0X8HWN6
names: Similarity
messages: Belongs to the HGH1 family.

45286:AW171 hschr74422
gene id: 45286:AW171_hschr74422
uniprot id: A0A0X8HVP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family.
messages: Membrane

45286:AW171 hschr42235
gene id: 45286:AW171_hschr42235
uniprot id: A0A0X8HRY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG27 family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane

45286:AW171 hschr53251
gene id: 45286:AW171_hschr53251
uniprot id: A0A0X8HTN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

45286:AW171 hschr53031
gene id: 45286:AW171_hschr53031
uniprot id: A0A0X8HTF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Converts protoheme IX and farnesyl diphosphate to heme O.
messages: Membrane
messages: Mitochondrion membrane

45286:AW171 hschr2998
gene id: 45286:AW171_hschr2998
uniprot id: A0A109UX65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RTT106 family.
messages: Nucleus

45286:AW171 hschr31735
gene id: 45286:AW171_hschr31735
uniprot id: A0A120K1Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Nucleus

45286:AW171 hschr31790
gene id: 45286:AW171_hschr31790
uniprot id: A0A0X8HR56
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

45286:AW171 hschr31658
gene id: 45286:AW171_hschr31658
uniprot id: A0A109UYE8
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

45286:AW171 hschr53357
gene id: 45286:AW171_hschr53357
uniprot id: A0A120K2G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

45286:AW171 hschr2337
gene id: 45286:AW171_hschr2337
uniprot id: A0A125RDX1
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

45286:AW171 hschr53240
gene id: 45286:AW171_hschr53240
uniprot id: A0A0X8HT05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex DAD3 family.
messages: Nucleus
messages: kinetochore
messages: spindle

45286:AW171 hschr31988
gene id: 45286:AW171_hschr31988
uniprot id: A0A109UWQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HIT family.
messages: Cytoplasm

45286:AW171 hschr74450
gene id: 45286:AW171_hschr74450
uniprot id: A0A0X8HVT2
names: Subcellular Location Annotation
messages: Cytoplasm

45286:AW171 hschr31370
gene id: 45286:AW171_hschr31370
uniprot id: A0A120K1M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family.
messages: Cytoplasm
messages: Membrane

45286:AW171 hschr42410
gene id: 45286:AW171_hschr42410
uniprot id: A0A0X8HS82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingosine N-acyltransferase family.
messages: Membrane

45286:AW171 hschr42060
gene id: 45286:AW171_hschr42060
uniprot id: A0A0X8HT13
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr31760
gene id: 45286:AW171_hschr31760
uniprot id: A0A0X8HR57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize preautophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy.
messages: Belongs to the ATG17 family.
messages: Cytoplasm
messages: Membrane
messages: Preautophagosomal structure membrane

45286:AW171 hschr31869
gene id: 45286:AW171_hschr31869
uniprot id: A0A0X8HRA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYG1 (TC 2.A.94) family.
messages: Membrane

45286:AW171 hschr31985
gene id: 45286:AW171_hschr31985
uniprot id: A0A0X8HRH7
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr21093
gene id: 45286:AW171_hschr21093
uniprot id: A0A109UXC2
names: Similarity
messages: Belongs to the VPS26 family.

45286:AW171 hschr31768
gene id: 45286:AW171_hschr31768
uniprot id: A0A109UWJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Cytoplasm
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.

45286:AW171 hschr31892
gene id: 45286:AW171_hschr31892
uniprot id: A0A109UYH1
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

45286:AW171 hschr84756
gene id: 45286:AW171_hschr84756
uniprot id: A0A0X8HWG7
names: Similarity
messages: Belongs to the isochorismatase family.

45286:AW171 hschr31991
gene id: 45286:AW171_hschr31991
uniprot id: A0A0X8HRK1
names: Similarity
messages: Belongs to the GET4 family.

45286:AW171 hschr31915
gene id: 45286:AW171_hschr31915
uniprot id: A0A0X8HRE1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homodimer.
messages: Mitochondrion
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

45286:AW171 hschr21198
gene id: 45286:AW171_hschr21198
uniprot id: A0A109UXM3
names: Similarity
messages: Belongs to the CAP family.

45286:AW171 hschr84544
gene id: 45286:AW171_hschr84544
uniprot id: A0A109V061
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the small ribosomal subunit.
messages: Cytoplasm
messages: Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability.

45286:AW171 hschr42701
gene id: 45286:AW171_hschr42701
uniprot id: A0A0X8HST1
names: Similarity
names: Subunit
messages: Belongs to the EXO5 family.
messages: Monomer.

45286:AW171 hschr53252
gene id: 45286:AW171_hschr53252
uniprot id: A0A0X8HTU8
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

45286:AW171 hschr53341
gene id: 45286:AW171_hschr53341
uniprot id: A0A109UXI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor potential (TRP) ion channel family.
messages: Membrane

45286:AW171 hschr53261
gene id: 45286:AW171_hschr53261
uniprot id: A0A120K2E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the USE1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr2511
gene id: 45286:AW171_hschr2511
uniprot id: A0A109UWV4
names: Similarity
messages: Belongs to the dopey family.

45286:AW171 hschr2376
gene id: 45286:AW171_hschr2376
uniprot id: A0A120K0Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP25 family.
messages: Mitochondrial mRNA stabilization factor.
messages: Mitochondrion inner membrane

45286:AW171 hschr74451
gene id: 45286:AW171_hschr74451
uniprot id: A0A0X8HVZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

45286:AW171 hschr42186
gene id: 45286:AW171_hschr42186
uniprot id: A0A0X8HRV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku70 family.
messages: Nucleus
messages: telomere

45286:AW171 hschr42401
gene id: 45286:AW171_hschr42401
uniprot id: A0A120K260
names: Similarity
messages: Belongs to the PPC synthetase family.

45286:AW171 hschr42452
gene id: 45286:AW171_hschr42452
uniprot id: A0A0X8HS84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit B family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

45286:AW171 hschr2521
gene id: 45286:AW171_hschr2521
uniprot id: A0A120K146
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fungal Na(+)/H(+) exchanger family.
messages: Membrane

45286:AW171 hschr31526
gene id: 45286:AW171_hschr31526
uniprot id: A0A109UY38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

45286:AW171 hschr85079
gene id: 45286:AW171_hschr85079
uniprot id: A0A0X8HWZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Component of the 60S subunit of the ribosome.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus
messages: Part of the 60S ribosomal subunit.

45286:AW171 hschr31429
gene id: 45286:AW171_hschr31429
uniprot id: A0A120K1P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

45286:AW171 hschr2458
gene id: 45286:AW171_hschr2458
uniprot id: A0A120K126
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

45286:AW171 hschr84722
gene id: 45286:AW171_hschr84722
uniprot id: A0A0X8HW99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

45286:AW171 hschr53169
gene id: 45286:AW171_hschr53169
uniprot id: A0A0X8HTN0
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 heme c group covalently per subunit.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr2520
gene id: 45286:AW171_hschr2520
uniprot id: A0A120K141
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAC3 family.
messages: Nucleus envelope

45286:AW171 hschr63600
gene id: 45286:AW171_hschr63600
uniprot id: A0A0X8HU97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-Z subfamily.
messages: Cytoplasm

45286:AW171 hschr31564
gene id: 45286:AW171_hschr31564
uniprot id: A0A120K1T2
names: Similarity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.

45286:AW171 hschr63923
gene id: 45286:AW171_hschr63923
uniprot id: A0A0X8HUY1
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr31329
gene id: 45286:AW171_hschr31329
uniprot id: A0A109UVU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPS2 family.
messages: Cell membrane
messages: Membrane

45286:AW171 hschr21265
gene id: 45286:AW171_hschr21265
uniprot id: A0A109UVQ3
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

45286:AW171 hschr31358
gene id: 45286:AW171_hschr31358
uniprot id: A0A109UXW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

45286:AW171 hschr74216
gene id: 45286:AW171_hschr74216
uniprot id: A0A0X8HVB7
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

45286:AW171 hschr74091
gene id: 45286:AW171_hschr74091
uniprot id: A0A120K2N6
names: Function
names: Similarity
messages: Belongs to the dihydroxyacetone kinase (DAK) family.
messages: Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.

45286:AW171 hschr84513
gene id: 45286:AW171_hschr84513
uniprot id: A0A109UYA6
names: Similarity
messages: Belongs to the proteasome subunit S3 family.

45286:AW171 hschr53267
gene id: 45286:AW171_hschr53267
uniprot id: A0A0X8HTP3
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr31503
gene id: 45286:AW171_hschr31503
uniprot id: A0A109UYH4
names: Similarity
messages: Belongs to the EFG1/PHD1/stuA family.

45286:AW171 hschr42175
gene id: 45286:AW171_hschr42175
uniprot id: A0A0X8HRU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AEP2 family.
messages: Binds to the 5'UTR of the OLI1 mRNA.
messages: Mitochondrion
messages: Required for translation of the mitochondrial OLI1 transcript coding for the mitochondrial ATP synthase subunit 9.

45286:AW171 hschr31643
gene id: 45286:AW171_hschr31643
uniprot id: A0A109UWE0
names: Similarity
messages: Belongs to the glycosyltransferase 34 family.

45286:AW171 hschr31771
gene id: 45286:AW171_hschr31771
uniprot id: A0A0X8HR44
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

45286:AW171 hschr21053
gene id: 45286:AW171_hschr21053
uniprot id: A0A125RE27
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.

45286:AW171 hschr31916
gene id: 45286:AW171_hschr31916
uniprot id: A0A0X8HRD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE4 family.
messages: Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
messages: Component of the SMC5-SMC6 complex.
messages: Nucleus

45286:AW171 hschr31444
gene id: 45286:AW171_hschr31444
uniprot id: A0A120K1P6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.

45286:AW171 hschr2146
gene id: 45286:AW171_hschr2146
uniprot id: A0A109UWV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Mitochondrion inner membrane

45286:AW171 hschr74050
gene id: 45286:AW171_hschr74050
uniprot id: A0A0X8HV11
names: Similarity
messages: Belongs to the epsin family.

45286:AW171 hschr42284
gene id: 45286:AW171_hschr42284
uniprot id: A0A0X8HRY1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

45286:AW171 hschr21127
gene id: 45286:AW171_hschr21127
uniprot id: A0A120K1E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Mitochondrion

45286:AW171 hschr42113
gene id: 45286:AW171_hschr42113
uniprot id: A0A0X8HRR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

45286:AW171 hschr32002
gene id: 45286:AW171_hschr32002
uniprot id: A0A109UWQ1
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

45286:AW171 hschr42416
gene id: 45286:AW171_hschr42416
uniprot id: A0A109UZ03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Membrane

45286:AW171 hschr42349
gene id: 45286:AW171_hschr42349
uniprot id: A0A0X8HR43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

45286:AW171 hschr2897
gene id: 45286:AW171_hschr2897
uniprot id: A0A109UXS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

45286:AW171 hschr2213
gene id: 45286:AW171_hschr2213
uniprot id: A0A125RDV6
names: Similarity
messages: Belongs to the p23/wos2 family.

45286:AW171 hschr21129
gene id: 45286:AW171_hschr21129
uniprot id: A0A120K1E7
names: Similarity
messages: Belongs to the cullin family.

45286:AW171 hschr42283
gene id: 45286:AW171_hschr42283
uniprot id: A0A0X8HS14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase epsilon subunit B family.
messages: Nucleus

45286:AW171 hschr21286
gene id: 45286:AW171_hschr21286
uniprot id: A0A120K1J6
names: Similarity
messages: Belongs to the NARF family.

45286:AW171 hschr53255
gene id: 45286:AW171_hschr53255
uniprot id: A0A0X8HT14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Membrane
messages: nuclear pore complex

45286:AW171 hschr42592
gene id: 45286:AW171_hschr42592
uniprot id: A0A120K281
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.

45286:AW171 hschr21109
gene id: 45286:AW171_hschr21109
uniprot id: A0A109UXD9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

45286:AW171 hschr31549
gene id: 45286:AW171_hschr31549
uniprot id: A0A120K1S7
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr53019
gene id: 45286:AW171_hschr53019
uniprot id: A0A0X8HSL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Nucleus

45286:AW171 hschr21133
gene id: 45286:AW171_hschr21133
uniprot id: A0A109UXF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic12 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

45286:AW171 hschr42202
gene id: 45286:AW171_hschr42202
uniprot id: A0A0X8HRW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr84854
gene id: 45286:AW171_hschr84854
uniprot id: A0A0X8HW36
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

45286:AW171 hschr63535
gene id: 45286:AW171_hschr63535
uniprot id: A0A0X8HUA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YAE1 family.
messages: Cytoplasm
messages: Nucleus

45286:AW171 hschr42689
gene id: 45286:AW171_hschr42689
uniprot id: A0A109UZ36
names: Similarity
messages: Belongs to the glycosyltransferase 15 family.

45286:AW171 hschr42769
gene id: 45286:AW171_hschr42769
uniprot id: A0A109UX62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTP family.
messages: Involved in protein synthesis. Involved in microtubule stabilization.
messages: cytoskeleton

45286:AW171 hschr85087
gene id: 45286:AW171_hschr85087
uniprot id: A0A0X8HX25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

45286:AW171 hschr84734
gene id: 45286:AW171_hschr84734
uniprot id: A0A109V103
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST5 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

45286:AW171 hschr42375
gene id: 45286:AW171_hschr42375
uniprot id: A0A0X8HS37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.

45286:AW171 hschr52876
gene id: 45286:AW171_hschr52876
uniprot id: A0A0X8HSZ3
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr53215
gene id: 45286:AW171_hschr53215
uniprot id: A0A0X8HTL1
names: Similarity
messages: Belongs to the RMD1/sif2 family.

45286:AW171 hschr53396
gene id: 45286:AW171_hschr53396
uniprot id: A0A0X8HTZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG2 family.
messages: Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols.
messages: Endoplasmic reticulum membrane

45286:AW171 hschr31820
gene id: 45286:AW171_hschr31820
uniprot id: A0A0X8HR87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS36 family.
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).
messages: Cytoplasm
messages: Endosome

45286:AW171 hschr42679
gene id: 45286:AW171_hschr42679
uniprot id: A0A0X8HSR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

45286:AW171 hschr74284
gene id: 45286:AW171_hschr74284
uniprot id: A0A0X8HVG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

45286:AW171 hschr42558
gene id: 45286:AW171_hschr42558
uniprot id: A0A120K274
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS18 family.

45286:AW171 hschr53020
gene id: 45286:AW171_hschr53020
uniprot id: A0A0X8HTC0
names: Subcellular Location Annotation
messages: Peroxisome membrane
messages: cytosol

45286:AW171 hschr53391
gene id: 45286:AW171_hschr53391
uniprot id: A0A0X8HU35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ROT1 family.
messages: Endoplasmic reticulum membrane
messages: Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies.

45286:AW171 hschr74078
gene id: 45286:AW171_hschr74078
uniprot id: A0A109V0A9
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

45286:AW171 hschr2120
gene id: 45286:AW171_hschr2120
uniprot id: A0A109UWG9
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

45286:AW171 hschr53023
gene id: 45286:AW171_hschr53023
uniprot id: A0A120K2C2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

45286:AW171 hschr31575
gene id: 45286:AW171_hschr31575
uniprot id: A0A120K1T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: microtubule organizing center

45286:AW171 hschr74241
gene id: 45286:AW171_hschr74241
uniprot id: A0A120K2Q0
names: Similarity
messages: In the C-terminal section; belongs to the trehalose phosphatase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 20 family.

45286:AW171 hschr63844
gene id: 45286:AW171_hschr63844
uniprot id: A0A120K2K9
names: Similarity
messages: Belongs to the VPS8 family.

45286:AW171 hschr2290
gene id: 45286:AW171_hschr2290
uniprot id: A0A109UWH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

45286:AW171 hschr63955
gene id: 45286:AW171_hschr63955
uniprot id: A0A0X8HUB3
names: Similarity
messages: Belongs to the EFG1 family.

45286:AW171 hschr42712
gene id: 45286:AW171_hschr42712
uniprot id: A0A0X8HSU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Nucleus

45286:AW171 hschr31478
gene id: 45286:AW171_hschr31478
uniprot id: A0A120K1R0
names: Similarity
messages: Belongs to the prephenate/arogenate dehydrogenase family.

45286:AW171 hschr42078
gene id: 45286:AW171_hschr42078
uniprot id: A0A0X8HRM5
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

45286:AW171 hschr84718
gene id: 45286:AW171_hschr84718
uniprot id: A0A120K2U9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Heterotrimer.
messages: Nucleus

45286:AW171 hschr63761
gene id: 45286:AW171_hschr63761
uniprot id: A0A0X8HUS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion inner membrane
messages: Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.

45286:AW171 hschr73999
gene id: 45286:AW171_hschr73999
uniprot id: A0A0X8HUY9
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

45286:AW171 hschr2260
gene id: 45286:AW171_hschr2260
uniprot id: A0A109UWD9
names: Similarity
messages: Belongs to the protein kinase superfamily.

45286:AW171 hschr31673
gene id: 45286:AW171_hschr31673
uniprot id: A0A109UYF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG12 family.
messages: Forms a conjugate with ATG5.
messages: Membrane
messages: Preautophagosomal structure membrane
messages: Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.

45286:AW171 hschr42655
gene id: 45286:AW171_hschr42655
uniprot id: A0A0X8HSN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP16 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

45286:AW171 hschr63657
gene id: 45286:AW171_hschr63657
uniprot id: A0A109UZL0
names: Similarity
messages: Belongs to the cytochrome P450 family.

45286:AW171 hschr42533
gene id: 45286:AW171_hschr42533
uniprot id: A0A0X8HSG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Membrane

45286:AW171 hschr74279
gene id: 45286:AW171_hschr74279
uniprot id: A0A0X8HVM0
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

45286:AW171 hschr84552
gene id: 45286:AW171_hschr84552
uniprot id: A0A0X8HVY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP17 family.
messages: nucleolus

45286:AW171 hschr31595
gene id: 45286:AW171_hschr31595
uniprot id: A0A120K1U2
names: Similarity
messages: Belongs to the asparaginase 1 family.

45286:AW171 hschr21186
gene id: 45286:AW171_hschr21186
uniprot id: A0A109UXN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

45286:AW171 hschr74312
gene id: 45286:AW171_hschr74312
uniprot id: A0A0X8HV31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr84999
gene id: 45286:AW171_hschr84999
uniprot id: A0A0X8HWD3
names: Similarity
messages: Belongs to the AAA ATPase family.

45286:AW171 hschr84965
gene id: 45286:AW171_hschr84965
uniprot id: A0A0X8HWS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

45286:AW171 hschr42475
gene id: 45286:AW171_hschr42475
uniprot id: A0A109UZ57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF2/ABP1 family.
messages: nucleolus

45286:AW171 hschr2245
gene id: 45286:AW171_hschr2245
uniprot id: A0A109UWC9
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr42690
gene id: 45286:AW171_hschr42690
uniprot id: A0A0X8HSQ2
names: Similarity
messages: Belongs to the TTC4 family.

45286:AW171 hschr74090
gene id: 45286:AW171_hschr74090
uniprot id: A0A120K2N3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Nucleus

45286:AW171 hschr31299
gene id: 45286:AW171_hschr31299
uniprot id: A0A109UXU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MATALPHA1 family.
messages: Nucleus

45286:AW171 hschr63522
gene id: 45286:AW171_hschr63522
uniprot id: A0A0X8HUA2
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

45286:AW171 hschr2101
gene id: 45286:AW171_hschr2101
uniprot id: A0A109UW52
names: Function
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.
messages: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.

45286:AW171 hschr42817
gene id: 45286:AW171_hschr42817
uniprot id: A0A109UX73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AEP1 family.
messages: Mitochondrion
messages: Required for translation of the mitochondrial OLI1 transcript encoding subunit 9 of mitochondrial ATP synthase.

45286:AW171 hschr42328
gene id: 45286:AW171_hschr42328
uniprot id: A0A0X8HS48
names: Similarity
messages: Belongs to the peptidase C12 family.

45286:AW171 hschr42658
gene id: 45286:AW171_hschr42658
uniprot id: A0A109UX40
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

45286:AW171 hschr84776
gene id: 45286:AW171_hschr84776
uniprot id: A0A0X8HWC0
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

45286:AW171 hschr31958
gene id: 45286:AW171_hschr31958
uniprot id: A0A109UZ17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Endomembrane system
messages: Vacuole membrane

45286:AW171 hschr53457
gene id: 45286:AW171_hschr53457
uniprot id: A0A0X8HU34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

45286:AW171 hschr53156
gene id: 45286:AW171_hschr53156
uniprot id: A0A0X8HSV0
names: Function
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

45286:AW171 hschr42289
gene id: 45286:AW171_hschr42289
uniprot id: A0A0X8HS05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr84836
gene id: 45286:AW171_hschr84836
uniprot id: A0A0X8HWM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MMM1 family.
messages: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
messages: Endoplasmic reticulum membrane
messages: Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.

45286:AW171 hschr31607
gene id: 45286:AW171_hschr31607
uniprot id: A0A120K1W0
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr63505
gene id: 45286:AW171_hschr63505
uniprot id: A0A0X8HU96
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr74020
gene id: 45286:AW171_hschr74020
uniprot id: A0A0X8HUJ5
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

45286:AW171 hschr53444
gene id: 45286:AW171_hschr53444
uniprot id: A0A0X8HU39
names: Function
names: Similarity
messages: Belongs to the peptidase T1A family.
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

45286:AW171 hschr42137
gene id: 45286:AW171_hschr42137
uniprot id: A0A109UWS9
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

45286:AW171 hschr31534
gene id: 45286:AW171_hschr31534
uniprot id: A0A120K1S2
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

45286:AW171 hschr42716
gene id: 45286:AW171_hschr42716
uniprot id: A0A0X8HSU2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

45286:AW171 hschr42699
gene id: 45286:AW171_hschr42699
uniprot id: A0A0X8HSN5
names: Similarity
messages: Belongs to the PGA52 family.

45286:AW171 hschr63500
gene id: 45286:AW171_hschr63500
uniprot id: A0A0X8HUA5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS7 family.

45286:AW171 hschr2548
gene id: 45286:AW171_hschr2548
uniprot id: A0A109UXA7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

45286:AW171 hschr84982
gene id: 45286:AW171_hschr84982
uniprot id: A0A0X8HWQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Cytoplasm

45286:AW171 hschr42586
gene id: 45286:AW171_hschr42586
uniprot id: A0A0X8HRR6
names: Similarity
messages: Belongs to the RRP15 family.

45286:AW171 hschr31974
gene id: 45286:AW171_hschr31974
uniprot id: A0A0X8HRI0
names: Similarity
messages: Belongs to the IMPACT family.

45286:AW171 hschr63925
gene id: 45286:AW171_hschr63925
uniprot id: A0A109V023
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

45286:AW171 hschr21174
gene id: 45286:AW171_hschr21174
uniprot id: A0A109UXX6
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.

45286:AW171 hschr53165
gene id: 45286:AW171_hschr53165
uniprot id: A0A0X8HTN5
names: Similarity
messages: Belongs to the RNase Z family.

45286:AW171 hschr2475
gene id: 45286:AW171_hschr2475
uniprot id: A0A120K130
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus

45286:AW171 hschr2989
gene id: 45286:AW171_hschr2989
uniprot id: A0A109UX85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPC110 family.
messages: Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication. Potential role in cross-linking filaments or anchoring other molecules. It is essential for growth.
messages: Nucleus
messages: spindle pole body

45286:AW171 hschr2208
gene id: 45286:AW171_hschr2208
uniprot id: A0A109UW95
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Mitochondrion
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

45286:AW171 hschr53170
gene id: 45286:AW171_hschr53170
uniprot id: A0A0X8HTK6
names: Similarity
messages: Belongs to the actin family.

45286:AW171 hschr31378
gene id: 45286:AW171_hschr31378
uniprot id: A0A109UVX6
names: Similarity
messages: Belongs to the cyclin family.

45286:AW171 hschr42225
gene id: 45286:AW171_hschr42225
uniprot id: A0A0X8HQW9
names: Similarity
messages: Belongs to the MNN1/MNT family.

45286:AW171 hschr2320
gene id: 45286:AW171_hschr2320
uniprot id: A0A109UWJ5
names: Function
names: Similarity
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

45286:AW171 hschr74157
gene id: 45286:AW171_hschr74157
uniprot id: A0A120K2N9
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

45286:AW171 hschr42849
gene id: 45286:AW171_hschr42849
uniprot id: A0A109UX81
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

45286:AW171 hschr21166
gene id: 45286:AW171_hschr21166
uniprot id: A0A120K1F4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGW family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.

45286:AW171 hschr213
gene id: 45286:AW171_hschr213
uniprot id: A0A120K0N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

45286:AW171 hschr2346
gene id: 45286:AW171_hschr2346
uniprot id: A0A120K0Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.
messages: Nucleus

45286:AW171 hschr42158
gene id: 45286:AW171_hschr42158
uniprot id: A0A0X8HRW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the CWC24 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

45286:AW171 hschr42615
gene id: 45286:AW171_hschr42615
uniprot id: A0A0X8HSQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom5 family.
messages: Membrane
messages: Mitochondrion outer membrane

45286:AW171 hschr21249
gene id: 45286:AW171_hschr21249
uniprot id: A0A109UXP7
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

45286:AW171 hschr31319
gene id: 45286:AW171_hschr31319
uniprot id: A0A109UY68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRB/QCR7 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

45286:AW171 hschr32053
gene id: 45286:AW171_hschr32053
uniprot id: A0A109UYP6
names: Similarity
messages: Belongs to the peptidase S8 family.

45286:AW171 hschr63575
gene id: 45286:AW171_hschr63575
uniprot id: A0A0X8HUB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDC1 family.
messages: Membrane
messages: Nucleus membrane
messages: nuclear pore complex

45286:AW171 hschr74100
gene id: 45286:AW171_hschr74100
uniprot id: A0A0X8HV71
names: Similarity
messages: Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.

45286:AW171 hschr31451
gene id: 45286:AW171_hschr31451
uniprot id: A0A109UW25
names: Similarity
messages: Belongs to the beclin family.

45286:AW171 hschr52997
gene id: 45286:AW171_hschr52997
uniprot id: A0A0X8HTA8
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.

45286:AW171 hschr31327
gene id: 45286:AW171_hschr31327
uniprot id: A0A120K1K3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: GTPase-activating protein for the ADP ribosylation factor family.

45286:AW171 hschr74055
gene id: 45286:AW171_hschr74055
uniprot id: A0A0X8HV61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation.
messages: Cytoplasm
messages: Nucleus

45286:AW171 hschr2898
gene id: 45286:AW171_hschr2898
uniprot id: A0A109UX42
names: Subcellular Location Annotation
messages: Cytoplasm

45286:AW171 hschr84582
gene id: 45286:AW171_hschr84582
uniprot id: A0A120K2T2
names: Subcellular Location Annotation
messages: Cytoplasm

45286:AW171 hschr63856
gene id: 45286:AW171_hschr63856
uniprot id: A0A0X8HUQ5
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

45286:AW171 hschr42708
gene id: 45286:AW171_hschr42708
uniprot id: A0A109UZ64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM50 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Mitochondrion inner membrane

45286:AW171 hschr31940
gene id: 45286:AW171_hschr31940
uniprot id: A0A120K211
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Component of the INO80 chromatin-remodeling complex.
messages: Nucleus
messages: The DBINO region is involved in binding to DNA.

45286:AW171 hschr84565
gene id: 45286:AW171_hschr84565
uniprot id: A0A109V0A0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Membrane
messages: Probably involved in transport through the plasma membrane.

45286:AW171 hschr74487
gene id: 45286:AW171_hschr74487
uniprot id: A0A0X8HVW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

45286:AW171 hschr53152
gene id: 45286:AW171_hschr53152
uniprot id: A0A0X8HTG5
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

45286:AW171 hschr74476
gene id: 45286:AW171_hschr74476
uniprot id: A0A0X8HVT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.

45286:AW171 hschr42419
gene id: 45286:AW171_hschr42419
uniprot id: A0A0X8HSA5
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

45286:AW171 hschr42357
gene id: 45286:AW171_hschr42357
uniprot id: A0A0X8HS63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SHO1 family.
messages: Cell membrane
messages: Membrane

45286:AW171 hschr31995
gene id: 45286:AW171_hschr31995
uniprot id: A0A0X8HRI7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

45286:AW171 hschr52951
gene id: 45286:AW171_hschr52951
uniprot id: A0A109UZY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

45286:AW171 hschr2537
gene id: 45286:AW171_hschr2537
uniprot id: A0A120K157
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS18 family.
messages: Membrane

45286:AW171 hschr84860
gene id: 45286:AW171_hschr84860
uniprot id: A0A120K2W5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBP4 family.
messages: Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b.
messages: Mitochondrion inner membrane

45286:AW171 hschr63573
gene id: 45286:AW171_hschr63573
uniprot id: A0A0X8HUA0
names: Similarity
messages: Belongs to the UPL family. TOM1/PTR1 subfamily.

45286:AW171 hschr31494
gene id: 45286:AW171_hschr31494
uniprot id: A0A109UY27
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.

45286:AW171 hschr53276
gene id: 45286:AW171_hschr53276
uniprot id: A0A120K2E9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

45286:AW171 hschr74469
gene id: 45286:AW171_hschr74469
uniprot id: A0A0X8HVS4
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

45286:AW171 hschr53208
gene id: 45286:AW171_hschr53208
uniprot id: A0A120K2E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

45286:AW171 hschr53286
gene id: 45286:AW171_hschr53286
uniprot id: A0A0X8HTU4
names: Similarity
messages: Belongs to the MAD1 family.

45286:AW171 hschr42853
gene id: 45286:AW171_hschr42853
uniprot id: A0A0X8HT17
names: Similarity
names: Subunit
messages: Belongs to the AlaDH/PNT family.
messages: Monomer.

45286:AW171 hschr42256
gene id: 45286:AW171_hschr42256
uniprot id: A0A0X8HRY5
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr85017
gene id: 45286:AW171_hschr85017
uniprot id: A0A0X8HWE3
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

45286:AW171 hschr53002
gene id: 45286:AW171_hschr53002
uniprot id: A0A0X8HTB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.
messages: Belongs to the COG6 family.
messages: Component of the conserved oligomeric Golgi complex.
messages: Golgi apparatus membrane
messages: Membrane

45286:AW171 hschr74271
gene id: 45286:AW171_hschr74271
uniprot id: A0A109UY41
names: Similarity
messages: Belongs to the SPT2 family.

45286:AW171 hschr42839
gene id: 45286:AW171_hschr42839
uniprot id: A0A0X8HSX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC4 family.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
messages: actin patch

45286:AW171 hschr74212
gene id: 45286:AW171_hschr74212
uniprot id: A0A109V0N7
names: Similarity
messages: Belongs to the actin family.

45286:AW171 hschr2975
gene id: 45286:AW171_hschr2975
uniprot id: A0A125RE17
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

45286:AW171 hschr31410
gene id: 45286:AW171_hschr31410
uniprot id: A0A109UXU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MATALPHA1 family.
messages: Nucleus

45286:AW171 hschr21285
gene id: 45286:AW171_hschr21285
uniprot id: A0A120K1J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Cytoplasm
messages: Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.
messages: Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.
messages: Mitochondrion
messages: The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.

45286:AW171 hschr31684
gene id: 45286:AW171_hschr31684
uniprot id: A0A120K1Y4
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr63530
gene id: 45286:AW171_hschr63530
uniprot id: A0A109UXN2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the deoxyhypusine hydroxylase family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.
messages: Cytoplasm
messages: Nucleus

45286:AW171 hschr53061
gene id: 45286:AW171_hschr53061
uniprot id: A0A0X8HTH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the WD repeat PRL1/PRL2 family.
messages: Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.
messages: Nucleus

45286:AW171 hschr42542
gene id: 45286:AW171_hschr42542
uniprot id: A0A120K275
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the F-actin-capping protein beta subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.
messages: cytoskeleton

45286:AW171 hschr2246
gene id: 45286:AW171_hschr2246
uniprot id: A0A125RDW0
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.

45286:AW171 hschr2452
gene id: 45286:AW171_hschr2452
uniprot id: A0A109UWQ5
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

45286:AW171 hschr52949
gene id: 45286:AW171_hschr52949
uniprot id: A0A109UZB5
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the ribosome.

45286:AW171 hschr63563
gene id: 45286:AW171_hschr63563
uniprot id: A0A120K2I2
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

45286:AW171 hschr21023
gene id: 45286:AW171_hschr21023
uniprot id: A0A109UY01
names: Similarity
messages: Belongs to the RNR ribonuclease family.

45286:AW171 hschr53322
gene id: 45286:AW171_hschr53322
uniprot id: A0A0X8HTV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: kinetochore
messages: spindle

45286:AW171 hschr32016
gene id: 45286:AW171_hschr32016
uniprot id: A0A120K220
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

45286:AW171 hschr52892
gene id: 45286:AW171_hschr52892
uniprot id: A0A0X8HT72
names: Similarity
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

45286:AW171 hschr248
gene id: 45286:AW171_hschr248
uniprot id: A0A109UVW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck

45286:AW171 hschr31850
gene id: 45286:AW171_hschr31850
uniprot id: A0A109UZA4
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

45286:AW171 hschr21138
gene id: 45286:AW171_hschr21138
uniprot id: A0A109UXK4
names: Function
names: Similarity
messages: Belongs to the LplA family.
messages: Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.

45286:AW171 hschr85071
gene id: 45286:AW171_hschr85071
uniprot id: A0A0X8HWX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG8 family.
messages: Membrane
messages: autophagosome membrane

45286:AW171 hschr53443
gene id: 45286:AW171_hschr53443
uniprot id: A0A0X8HTF2
names: Subcellular Location Annotation
messages: nucleolus

45286:AW171 hschr2894
gene id: 45286:AW171_hschr2894
uniprot id: A0A120K169
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

45286:AW171 hschr243
gene id: 45286:AW171_hschr243
uniprot id: A0A120K0N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

45286:AW171 hschr2433
gene id: 45286:AW171_hschr2433
uniprot id: A0A125RDY3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

45286:AW171 hschr31562
gene id: 45286:AW171_hschr31562
uniprot id: A0A120K1T5
names: Similarity
messages: Belongs to the malate synthase family.

45286:AW171 hschr74051
gene id: 45286:AW171_hschr74051
uniprot id: A0A0X8HV96
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.

45286:AW171 hschr53308
gene id: 45286:AW171_hschr53308
uniprot id: A0A109UZH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPS2 family.
messages: Component of the spindle pole body (SPB) required for insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication.
messages: Membrane
messages: Nucleus membrane
messages: spindle pole body

45286:AW171 hschr2392
gene id: 45286:AW171_hschr2392
uniprot id: A0A120K106
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

45286:AW171 hschr84517
gene id: 45286:AW171_hschr84517
uniprot id: A0A0X8HW33
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

45286:AW171 hschr42510
gene id: 45286:AW171_hschr42510
uniprot id: A0A120K267
names: Similarity
messages: Belongs to the PET191 family.

45286:AW171 hschr63869
gene id: 45286:AW171_hschr63869
uniprot id: A0A0X8HUV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NASP family.
messages: Nucleus

45286:AW171 hschr21122
gene id: 45286:AW171_hschr21122
uniprot id: A0A109UXH3
names: Similarity
messages: Belongs to the PAF1 family.

45286:AW171 hschr2895
gene id: 45286:AW171_hschr2895
uniprot id: A0A109UX27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane

45286:AW171 hschr42587
gene id: 45286:AW171_hschr42587
uniprot id: A0A0X8HSJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

45286:AW171 hschr53153
gene id: 45286:AW171_hschr53153
uniprot id: A0A0X8HTN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr74011
gene id: 45286:AW171_hschr74011
uniprot id: A0A109UXY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

45286:AW171 hschr74122
gene id: 45286:AW171_hschr74122
uniprot id: A0A109UZX6
names: Similarity
messages: Belongs to the AHA1 family.

45286:AW171 hschr284
gene id: 45286:AW171_hschr284
uniprot id: A0A109UWR6
names: Similarity
messages: Belongs to the EFR3 family.

45286:AW171 hschr2241
gene id: 45286:AW171_hschr2241
uniprot id: A0A109UWB5
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.

45286:AW171 hschr21065
gene id: 45286:AW171_hschr21065
uniprot id: A0A120K1D1
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

45286:AW171 hschr63948
gene id: 45286:AW171_hschr63948
uniprot id: A0A0X8HUX6
names: Similarity
messages: Belongs to the GTP cyclohydrolase I family.

45286:AW171 hschr63919
gene id: 45286:AW171_hschr63919
uniprot id: A0A0X8HV17
names: Function
names: Similarity
messages: Belongs to the peptidase T1A family.
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

45286:AW171 hschr74226
gene id: 45286:AW171_hschr74226
uniprot id: A0A109V026
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).

45286:AW171 hschr53394
gene id: 45286:AW171_hschr53394
uniprot id: A0A0X8HU42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG3 family.
messages: Cytoplasm

45286:AW171 hschr74205
gene id: 45286:AW171_hschr74205
uniprot id: A0A0X8HVE4
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

45286:AW171 hschr63677
gene id: 45286:AW171_hschr63677
uniprot id: A0A109UZR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

45286:AW171 hschr31931
gene id: 45286:AW171_hschr31931
uniprot id: A0A0X8HRE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup84/Nup107 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: Part of the nuclear pore complex (NPC).
messages: nuclear pore complex

45286:AW171 hschr31927
gene id: 45286:AW171_hschr31927
uniprot id: A0A120K208
names: Similarity
messages: Belongs to the putative lipase ROG1 family.

45286:AW171 hschr42071
gene id: 45286:AW171_hschr42071
uniprot id: A0A109UYP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

45286:AW171 hschr31644
gene id: 45286:AW171_hschr31644
uniprot id: A0A109UZ33
names: Similarity
messages: Belongs to the peroxisomal targeting signal receptor family.

45286:AW171 hschr42765
gene id: 45286:AW171_hschr42765
uniprot id: A0A0X8HSW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.

45286:AW171 hschr63786
gene id: 45286:AW171_hschr63786
uniprot id: A0A120K2K4
names: Similarity
messages: Belongs to the YIP1 family.

45286:AW171 hschr42257
gene id: 45286:AW171_hschr42257
uniprot id: A0A109UYT9
names: Subcellular Location Annotation
messages: Mitochondrion

45286:AW171 hschr31953
gene id: 45286:AW171_hschr31953
uniprot id: A0A109UYT6
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

45286:AW171 hschr31641
gene id: 45286:AW171_hschr31641
uniprot id: A0A120K1V7
names: Similarity
messages: Belongs to the peptidase S9B family.

45286:AW171 hschr63497
gene id: 45286:AW171_hschr63497
uniprot id: A0A120K2H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

45286:AW171 hschr42499
gene id: 45286:AW171_hschr42499
uniprot id: A0A0X8HSF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.
messages: Vacuole membrane

45286:AW171 hschr42218
gene id: 45286:AW171_hschr42218
uniprot id: A0A0X8HRX8
names: Similarity
messages: Belongs to the cyclin family.

45286:AW171 hschr32006
gene id: 45286:AW171_hschr32006
uniprot id: A0A0X8HRK4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

45286:AW171 hschr84904
gene id: 45286:AW171_hschr84904
uniprot id: A0A120K2W8
names: Similarity
messages: Belongs to the END3 family.

45286:AW171 hschr74196
gene id: 45286:AW171_hschr74196
uniprot id: A0A120K2P2
names: Similarity
messages: Belongs to the peptidase S9B family.

45286:AW171 hschr53374
gene id: 45286:AW171_hschr53374
uniprot id: A0A0X8HTZ7
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

45286:AW171 hschr276
gene id: 45286:AW171_hschr276
uniprot id: A0A120K0Q4
names: Subunit
messages: Homodimer.

45286:AW171 hschr63686
gene id: 45286:AW171_hschr63686
uniprot id: A0A0X8HTU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

45286:AW171 hschr31742
gene id: 45286:AW171_hschr31742
uniprot id: A0A0X8HR30
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.

45286:AW171 hschr42521
gene id: 45286:AW171_hschr42521
uniprot id: A0A0X8HSF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSE2 family.
messages: Nucleus

45286:AW171 hschr21077
gene id: 45286:AW171_hschr21077
uniprot id: A0A120K1D0
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

45286:AW171 hschr31954
gene id: 45286:AW171_hschr31954
uniprot id: A0A0X8HRG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm

45286:AW171 hschr21017
gene id: 45286:AW171_hschr21017
uniprot id: A0A120K1C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane

45286:AW171 hschr2164
gene id: 45286:AW171_hschr2164
uniprot id: A0A109UW93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

45286:AW171 hschr31848
gene id: 45286:AW171_hschr31848
uniprot id: A0A109UYM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.

45286:AW171 hschr52947
gene id: 45286:AW171_hschr52947
uniprot id: A0A0X8HT64
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr21004
gene id: 45286:AW171_hschr21004
uniprot id: A0A120K1A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck

45286:AW171 hschr53049
gene id: 45286:AW171_hschr53049
uniprot id: A0A0X8HSN3
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

45286:AW171 hschr53325
gene id: 45286:AW171_hschr53325
uniprot id: A0A120K2F4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NIP7 family.
messages: Interacts with pre-ribosome complex.
messages: Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.
messages: nucleolus

45286:AW171 hschr42059
gene id: 45286:AW171_hschr42059
uniprot id: A0A109UZD5
names: Similarity
messages: Belongs to the SUI1 family.

45286:AW171 hschr2186
gene id: 45286:AW171_hschr2186
uniprot id: A0A120K0T3
names: Similarity
messages: Belongs to the cytidylyltransferase family.

45286:AW171 hschr53067
gene id: 45286:AW171_hschr53067
uniprot id: A0A0X8HTD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

45286:AW171 hschr63633
gene id: 45286:AW171_hschr63633
uniprot id: A0A0X8HUF3
names: Similarity
messages: Belongs to the heat shock protein 70 family.

45286:AW171 hschr31704
gene id: 45286:AW171_hschr31704
uniprot id: A0A109UWH8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: telomere

45286:AW171 hschr74083
gene id: 45286:AW171_hschr74083
uniprot id: A0A0X8HVB6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).
messages: Cytoplasm

45286:AW171 hschr52936
gene id: 45286:AW171_hschr52936
uniprot id: A0A0X8HT85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
messages: Homodimer.

45286:AW171 hschr42519
gene id: 45286:AW171_hschr42519
uniprot id: A0A0X8HSJ7
names: Similarity
messages: Belongs to the TPP enzyme family.

45286:AW171 hschr2393
gene id: 45286:AW171_hschr2393
uniprot id: A0A120K113
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

45286:AW171 hschr42100
gene id: 45286:AW171_hschr42100
uniprot id: A0A0X8HQP7
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

45286:AW171 hschr74068
gene id: 45286:AW171_hschr74068
uniprot id: A0A0X8HV95
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

45286:AW171 hschr42636
gene id: 45286:AW171_hschr42636
uniprot id: A0A0X8HSL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EST3 family.
messages: Component of the telomerase complex involved in telomere replication. Stimulates RNA/DNA heteroduplex unwinding which favors the telomere replication by the telomerase.
messages: Nucleus
messages: telomere

45286:AW171 hschr31945
gene id: 45286:AW171_hschr31945
uniprot id: A0A0X8HRG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

45286:AW171 hschr74056
gene id: 45286:AW171_hschr74056
uniprot id: A0A109UZU9
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr42581
gene id: 45286:AW171_hschr42581
uniprot id: A0A0X8HSN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 22 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

45286:AW171 hschr53159
gene id: 45286:AW171_hschr53159
uniprot id: A0A0X8HTJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: centromere

45286:AW171 hschr84802
gene id: 45286:AW171_hschr84802
uniprot id: A0A0X8HWJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

45286:AW171 hschr84716
gene id: 45286:AW171_hschr84716
uniprot id: A0A120K2U5
names: Similarity
messages: Belongs to the APC10 family.

45286:AW171 hschr42485
gene id: 45286:AW171_hschr42485
uniprot id: A0A0X8HSD8
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

45286:AW171 hschr31815
gene id: 45286:AW171_hschr31815
uniprot id: A0A109UYJ4
names: Similarity
messages: Belongs to the SRR1 family.

45286:AW171 hschr42242
gene id: 45286:AW171_hschr42242
uniprot id: A0A109UYZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 4 family.
messages: Membrane

45286:AW171 hschr31651
gene id: 45286:AW171_hschr31651
uniprot id: A0A109UYC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

45286:AW171 hschr63850
gene id: 45286:AW171_hschr63850
uniprot id: A0A0X8HUX8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

45286:AW171 hschr63589
gene id: 45286:AW171_hschr63589
uniprot id: A0A0X8HTN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the SRB8-11 complex, which itself associates with the Mediator complex.
messages: Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.
messages: Nucleus

45286:AW171 hschr53270
gene id: 45286:AW171_hschr53270
uniprot id: A0A0X8HTT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-Z subfamily.
messages: Cytoplasm

45286:AW171 hschr31800
gene id: 45286:AW171_hschr31800
uniprot id: A0A109UYL0
names: Function
names: Similarity
messages: Belongs to the dus family. Dus3 subfamily.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs.

45286:AW171 hschr31878
gene id: 45286:AW171_hschr31878
uniprot id: A0A120K202
names: Similarity
messages: Belongs to the peptidase C48 family.

45286:AW171 hschr31504
gene id: 45286:AW171_hschr31504
uniprot id: A0A109UY37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPC42 family.
messages: Forms a polymeric layer at the periphery of the spindle pole body (SPB) central plaque which has an essential function during SPB duplication and may facilitate attachment of the SPB to the nuclear membrane.
messages: spindle pole body

45286:AW171 hschr2157
gene id: 45286:AW171_hschr2157
uniprot id: A0A120K0T0
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

45286:AW171 hschr84984
gene id: 45286:AW171_hschr84984
uniprot id: A0A109UYP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC16 family. YJU2 subfamily.
messages: Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.
messages: Nucleus
messages: Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role (via N-terminus) in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. Further stabilizes spliceosome conformation for 3'-splice site docking (via C-terminus) promoting exon ligation.

45286:AW171 hschr42761
gene id: 45286:AW171_hschr42761
uniprot id: A0A0X8HSZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling.
messages: Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.
messages: Membrane
messages: Peroxisome membrane

45286:AW171 hschr2336
gene id: 45286:AW171_hschr2336
uniprot id: A0A109UWI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL43 family.
messages: Mitochondrion

45286:AW171 hschr74298
gene id: 45286:AW171_hschr74298
uniprot id: A0A0X8HVK4
names: Similarity
messages: Belongs to the PDCD5 family.

45286:AW171 hschr2531
gene id: 45286:AW171_hschr2531
uniprot id: A0A125RDZ6
names: Similarity
messages: Belongs to the glycosyl hydrolase 81 family.

45286:AW171 hschr42449
gene id: 45286:AW171_hschr42449
uniprot id: A0A0X8HSC3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

45286:AW171 hschr74360
gene id: 45286:AW171_hschr74360
uniprot id: A0A0X8HVP8
names: Similarity
messages: Belongs to the patched family.

45286:AW171 hschr21057
gene id: 45286:AW171_hschr21057
uniprot id: A0A125RE28
names: Function
names: Similarity
messages: Belongs to the IPK1 type 1 family.
messages: Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.

45286:AW171 hschr84602
gene id: 45286:AW171_hschr84602
uniprot id: A0A0X8HW75
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr74334
gene id: 45286:AW171_hschr74334
uniprot id: A0A120K2R0
names: Similarity
messages: Belongs to the ClpA/ClpB family.

45286:AW171 hschr32038
gene id: 45286:AW171_hschr32038
uniprot id: A0A109UYR3
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr53415
gene id: 45286:AW171_hschr53415
uniprot id: A0A0X8HTZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M76 family.
messages: Has a dual role in the assembly of mitochondrial ATPase.
messages: Mitochondrion inner membrane

45286:AW171 hschr42309
gene id: 45286:AW171_hschr42309
uniprot id: A0A120K249
names: Similarity
messages: Belongs to the yippee family.

45286:AW171 hschr42307
gene id: 45286:AW171_hschr42307
uniprot id: A0A0X8HS17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

45286:AW171 hschr42443
gene id: 45286:AW171_hschr42443
uniprot id: A0A109UYY3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

45286:AW171 hschr74170
gene id: 45286:AW171_hschr74170
uniprot id: A0A0X8HVB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

45286:AW171 hschr53034
gene id: 45286:AW171_hschr53034
uniprot id: A0A0X8HSM4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

45286:AW171 hschr84934
gene id: 45286:AW171_hschr84934
uniprot id: A0A109V0F5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

45286:AW171 hschr74000
gene id: 45286:AW171_hschr74000
uniprot id: A0A0X8HUY4
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

45286:AW171 hschr85066
gene id: 45286:AW171_hschr85066
uniprot id: A0A0X8HWV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.

45286:AW171 hschr31941
gene id: 45286:AW171_hschr31941
uniprot id: A0A109UYN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 5 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

45286:AW171 hschr42386
gene id: 45286:AW171_hschr42386
uniprot id: A0A109UZA8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

45286:AW171 hschr216
gene id: 45286:AW171_hschr216
uniprot id: A0A109UVU0
names: Subunit
messages: Monomer.

45286:AW171 hschr42379
gene id: 45286:AW171_hschr42379
uniprot id: A0A0X8HR64
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr2165
gene id: 45286:AW171_hschr2165
uniprot id: A0A109UW79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.
messages: Cytoplasm
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.

45286:AW171 hschr53006
gene id: 45286:AW171_hschr53006
uniprot id: A0A109UZG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

45286:AW171 hschr84833
gene id: 45286:AW171_hschr84833
uniprot id: A0A0X8HWM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC3 family.
messages: Nucleus

45286:AW171 hschr84730
gene id: 45286:AW171_hschr84730
uniprot id: A0A0X8HW91
names: Similarity
messages: Belongs to the SAPS family.

45286:AW171 hschr42637
gene id: 45286:AW171_hschr42637
uniprot id: A0A120K285
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.
messages: Cytoplasm

45286:AW171 hschr53053
gene id: 45286:AW171_hschr53053
uniprot id: A0A109UZA0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

45286:AW171 hschr31894
gene id: 45286:AW171_hschr31894
uniprot id: A0A120K204
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

45286:AW171 hschr74416
gene id: 45286:AW171_hschr74416
uniprot id: A0A109UY83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ALG14 family.
messages: Endoplasmic reticulum membrane
messages: Heterodimer with ALG13 to form a functional enzyme.
messages: Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.
messages: Membrane
messages: Nucleus membrane

45286:AW171 hschr31791
gene id: 45286:AW171_hschr31791
uniprot id: A0A0X8HR76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr53222
gene id: 45286:AW171_hschr53222
uniprot id: A0A0X8HTN7
names: Similarity
messages: Belongs to the glycosyl hydrolase 37 family.

45286:AW171 hschr85070
gene id: 45286:AW171_hschr85070
uniprot id: A0A109V167
names: Similarity
messages: Belongs to the non-repetitive/WGA-negative nucleoporin family.

45286:AW171 hschr31366
gene id: 45286:AW171_hschr31366
uniprot id: A0A109UXV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRM1 family.
messages: Cell membrane
messages: Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.

45286:AW171 hschr42459
gene id: 45286:AW171_hschr42459
uniprot id: A0A0X8HSB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor potential (TRP) ion channel family.
messages: Membrane

45286:AW171 hschr53361
gene id: 45286:AW171_hschr53361
uniprot id: A0A0X8HTZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.
messages: Nucleus

45286:AW171 hschr31964
gene id: 45286:AW171_hschr31964
uniprot id: A0A0X8HRG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase inhibitor family.
messages: Inhibits the enzyme activity of ATPase.
messages: Mitochondrion

45286:AW171 hschr53327
gene id: 45286:AW171_hschr53327
uniprot id: A0A109UXH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS29 family.
messages: Mitochondrion

45286:AW171 hschr74045
gene id: 45286:AW171_hschr74045
uniprot id: A0A120K2M9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Mitochondrion inner membrane

45286:AW171 hschr84499
gene id: 45286:AW171_hschr84499
uniprot id: A0A109UYA5
names: Similarity
messages: Belongs to the peptidase A1 family.

45286:AW171 hschr2193
gene id: 45286:AW171_hschr2193
uniprot id: A0A125RDV3
names: Domain
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DENR family.
messages: Cytoplasm
messages: Interacts with the 40S ribosomal subunit.
messages: The SUI1 domain may be involved in RNA binding.

45286:AW171 hschr74198
gene id: 45286:AW171_hschr74198
uniprot id: A0A0X8HVJ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.

45286:AW171 hschr2501
gene id: 45286:AW171_hschr2501
uniprot id: A0A109UWQ4
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

45286:AW171 hschr63691
gene id: 45286:AW171_hschr63691
uniprot id: A0A120K2J4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1 and GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-GET2 receptor, and returning it to the cytosol to initiate a new round of targeting. Cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in low-level resistance to the oxyanions arsenite and arsenate, and in heat tolerance.
messages: Belongs to the arsA ATPase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer. Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer. Interacts with the chloride channel protein GEF1.

45286:AW171 hschr63934
gene id: 45286:AW171_hschr63934
uniprot id: A0A0X8HUU6
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

45286:AW171 hschr2984
gene id: 45286:AW171_hschr2984
uniprot id: A0A120K1A3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YPT35 family.
messages: Endosome membrane
messages: Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.
messages: Vacuole membrane

45286:AW171 hschr63769
gene id: 45286:AW171_hschr63769
uniprot id: A0A109UZQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

45286:AW171 hschr74243
gene id: 45286:AW171_hschr74243
uniprot id: A0A0X8HVE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

45286:AW171 hschr53117
gene id: 45286:AW171_hschr53117
uniprot id: A0A120K2D2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
messages: Belongs to the NMD3 family.
messages: Cytoplasm
messages: Nucleus

45286:AW171 hschr84583
gene id: 45286:AW171_hschr84583
uniprot id: A0A0X8HW11
names: Similarity
messages: Belongs to the ClpA/ClpB family.

45286:AW171 hschr63937
gene id: 45286:AW171_hschr63937
uniprot id: A0A0X8HUX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

45286:AW171 hschr21061
gene id: 45286:AW171_hschr21061
uniprot id: A0A120K1C5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM5 / TYW2 family.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

45286:AW171 hschr74372
gene id: 45286:AW171_hschr74372
uniprot id: A0A0X8HVV0
names: Similarity
messages: Belongs to the LOC1 family.

45286:AW171 hschr85054
gene id: 45286:AW171_hschr85054
uniprot id: A0A120K2Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLD7 family.
messages: spindle pole

45286:AW171 hschr42129
gene id: 45286:AW171_hschr42129
uniprot id: A0A0X8HRS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

45286:AW171 hschr31754
gene id: 45286:AW171_hschr31754
uniprot id: A0A109UWJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS2 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr63894
gene id: 45286:AW171_hschr63894
uniprot id: A0A120K2L3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

45286:AW171 hschr2942
gene id: 45286:AW171_hschr2942
uniprot id: A0A109UX57
names: Subunit
messages: Consists of at least two heavy chains and a number of intermediate and light chains.

45286:AW171 hschr42145
gene id: 45286:AW171_hschr42145
uniprot id: A0A0X8HRR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

45286:AW171 hschr52878
gene id: 45286:AW171_hschr52878
uniprot id: A0A0X8HT40
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.

45286:AW171 hschr32021
gene id: 45286:AW171_hschr32021
uniprot id: A0A0X8HRJ9
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr52891
gene id: 45286:AW171_hschr52891
uniprot id: A0A0X8HT04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM18/AIM46 family.
messages: Mitochondrion

45286:AW171 hschr31337
gene id: 45286:AW171_hschr31337
uniprot id: A0A120K1L1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG22 family.
messages: Membrane
messages: Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.
messages: Vacuole membrane

45286:AW171 hschr63794
gene id: 45286:AW171_hschr63794
uniprot id: A0A0X8HUL2
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr42609
gene id: 45286:AW171_hschr42609
uniprot id: A0A109UX29
names: Similarity
messages: Belongs to the cyclin family.

45286:AW171 hschr31662
gene id: 45286:AW171_hschr31662
uniprot id: A0A109UYD8
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

45286:AW171 hschr2901
gene id: 45286:AW171_hschr2901
uniprot id: A0A109UWZ0
names: Similarity
messages: Belongs to the protein kinase superfamily.

45286:AW171 hschr42744
gene id: 45286:AW171_hschr42744
uniprot id: A0A0X8HSU7
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr31792
gene id: 45286:AW171_hschr31792
uniprot id: A0A0X8HR59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fungal cytochrome c oxidase subunit 7a family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr63593
gene id: 45286:AW171_hschr63593
uniprot id: A0A120K2I4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
messages: Mitochondrion
messages: Nucleus

45286:AW171 hschr74263
gene id: 45286:AW171_hschr74263
uniprot id: A0A0X8HVL8
names: Similarity
messages: Belongs to the MNN1/MNT family.

45286:AW171 hschr42819
gene id: 45286:AW171_hschr42819
uniprot id: A0A109UZJ3
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

45286:AW171 hschr42107
gene id: 45286:AW171_hschr42107
uniprot id: A0A109UZ46
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr21031
gene id: 45286:AW171_hschr21031
uniprot id: A0A120K1B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

45286:AW171 hschr84829
gene id: 45286:AW171_hschr84829
uniprot id: A0A109V0H0
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr42492
gene id: 45286:AW171_hschr42492
uniprot id: A0A109UYZ4
names: Similarity
messages: Belongs to the protein kinase superfamily.

45286:AW171 hschr84545
gene id: 45286:AW171_hschr84545
uniprot id: A0A0X8HVX0
names: Similarity
messages: Belongs to the AFG1 ATPase family.

45286:AW171 hschr42500
gene id: 45286:AW171_hschr42500
uniprot id: A0A0X8HSG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup85 family.
messages: Component of the nuclear pore complex (NPC).
messages: Functions as a component of the nuclear pore complex (NPC).
messages: nuclear pore complex

45286:AW171 hschr21234
gene id: 45286:AW171_hschr21234
uniprot id: A0A109UVN4
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

45286:AW171 hschr31828
gene id: 45286:AW171_hschr31828
uniprot id: A0A109UYK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COPE family.
messages: Cytoplasm
messages: Membrane
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

45286:AW171 hschr52865
gene id: 45286:AW171_hschr52865
uniprot id: A0A109UZD5
names: Similarity
messages: Belongs to the SUI1 family.

45286:AW171 hschr2284
gene id: 45286:AW171_hschr2284
uniprot id: A0A109UWB7
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

45286:AW171 hschr31414
gene id: 45286:AW171_hschr31414
uniprot id: A0A120K1N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: nucleolus

45286:AW171 hschr42837
gene id: 45286:AW171_hschr42837
uniprot id: A0A0X8HT20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.
messages: Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity). SPC associates with the translocon complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr42394
gene id: 45286:AW171_hschr42394
uniprot id: A0A0X8HR78
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

45286:AW171 hschr31950
gene id: 45286:AW171_hschr31950
uniprot id: A0A0X8HRG5
names: Similarity
messages: Belongs to the UPP synthase family.

45286:AW171 hschr2500
gene id: 45286:AW171_hschr2500
uniprot id: A0A125RDZ2
names: Similarity
messages: Belongs to the cullin family.

45286:AW171 hschr84632
gene id: 45286:AW171_hschr84632
uniprot id: A0A0X8HWA1
names: Similarity
messages: Belongs to the GST superfamily.

45286:AW171 hschr42169
gene id: 45286:AW171_hschr42169
uniprot id: A0A120K232
names: Similarity
messages: Belongs to the phosphohexose mutase family.

45286:AW171 hschr2387
gene id: 45286:AW171_hschr2387
uniprot id: A0A125RDX8
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

45286:AW171 hschr63936
gene id: 45286:AW171_hschr63936
uniprot id: A0A0X8HV12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex DAM1 family.
messages: Nucleus
messages: kinetochore
messages: spindle

45286:AW171 hschr31587
gene id: 45286:AW171_hschr31587
uniprot id: A0A109UY82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-O/MCM21 family.
messages: Nucleus

45286:AW171 hschr84773
gene id: 45286:AW171_hschr84773
uniprot id: A0A0X8HVY4
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

45286:AW171 hschr42395
gene id: 45286:AW171_hschr42395
uniprot id: A0A0X8HS71
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

45286:AW171 hschr21266
gene id: 45286:AW171_hschr21266
uniprot id: A0A109UXN4
names: Cofactor
messages: Divalent metal ions. Mg(2+) is the most effective.

45286:AW171 hschr42503
gene id: 45286:AW171_hschr42503
uniprot id: A0A0X8HSI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

45286:AW171 hschr74117
gene id: 45286:AW171_hschr74117
uniprot id: A0A0X8HV83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM31/MDM32 family.
messages: Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr84886
gene id: 45286:AW171_hschr84886
uniprot id: A0A0X8HWM2
names: Similarity
messages: Belongs to the heat shock protein 70 family.

45286:AW171 hschr42315
gene id: 45286:AW171_hschr42315
uniprot id: A0A0X8HS00
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

45286:AW171 hschr21287
gene id: 45286:AW171_hschr21287
uniprot id: A0A120K1L2
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.

45286:AW171 hschr21283
gene id: 45286:AW171_hschr21283
uniprot id: A0A109UY50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 16 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

45286:AW171 hschr31793
gene id: 45286:AW171_hschr31793
uniprot id: A0A0X8HR60
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

45286:AW171 hschr85086
gene id: 45286:AW171_hschr85086
uniprot id: A0A0X8HWY6
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.

45286:AW171 hschr31335
gene id: 45286:AW171_hschr31335
uniprot id: A0A109UY77
names: Similarity
messages: Belongs to the hexokinase family.

45286:AW171 hschr2374
gene id: 45286:AW171_hschr2374
uniprot id: A0A109UWZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

45286:AW171 hschr84697
gene id: 45286:AW171_hschr84697
uniprot id: A0A0X8HVT1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

45286:AW171 hschr42786
gene id: 45286:AW171_hschr42786
uniprot id: A0A120K298
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

45286:AW171 hschr84764
gene id: 45286:AW171_hschr84764
uniprot id: A0A120K2V4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

45286:AW171 hschr31900
gene id: 45286:AW171_hschr31900
uniprot id: A0A0X8HRC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL27 family.
messages: Mitochondrion

45286:AW171 hschr42602
gene id: 45286:AW171_hschr42602
uniprot id: A0A0X8HSK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

45286:AW171 hschr53103
gene id: 45286:AW171_hschr53103
uniprot id: A0A0X8HTJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ISY1 family.
messages: Nucleus

45286:AW171 hschr31865
gene id: 45286:AW171_hschr31865
uniprot id: A0A109UYK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PET117 family.
messages: Mitochondrion

45286:AW171 hschr42072
gene id: 45286:AW171_hschr42072
uniprot id: A0A0X8HRK9
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

45286:AW171 hschr31876
gene id: 45286:AW171_hschr31876
uniprot id: A0A109UYL1
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

45286:AW171 hschr2347
gene id: 45286:AW171_hschr2347
uniprot id: A0A120K0Z7
names: Similarity
messages: Belongs to the FUN14 family.

45286:AW171 hschr2115
gene id: 45286:AW171_hschr2115
uniprot id: A0A109UWT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

45286:AW171 hschr31833
gene id: 45286:AW171_hschr31833
uniprot id: A0A120K1Z7
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

45286:AW171 hschr42746
gene id: 45286:AW171_hschr42746
uniprot id: A0A0X8HSY2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: Maintains high levels of reduced glutathione in the cytosol.

45286:AW171 hschr74455
gene id: 45286:AW171_hschr74455
uniprot id: A0A0X8HVY8
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.

45286:AW171 hschr63652
gene id: 45286:AW171_hschr63652
uniprot id: A0A0X8HUK9
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

45286:AW171 hschr31633
gene id: 45286:AW171_hschr31633
uniprot id: A0A109UYQ9
names: Function
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

45286:AW171 hschr63868
gene id: 45286:AW171_hschr63868
uniprot id: A0A0X8HU55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck

45286:AW171 hschr21022
gene id: 45286:AW171_hschr21022
uniprot id: A0A125RE23
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.

45286:AW171 hschr53365
gene id: 45286:AW171_hschr53365
uniprot id: A0A0X8HTX6
names: Similarity
messages: Belongs to the Tango6 family.

45286:AW171 hschr31610
gene id: 45286:AW171_hschr31610
uniprot id: A0A120K1U7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SKP1 family.
messages: Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.
messages: Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.

45286:AW171 hschr53339
gene id: 45286:AW171_hschr53339
uniprot id: A0A0X8HTW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat COPB2 family.
messages: COPI-coated vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

45286:AW171 hschr2341
gene id: 45286:AW171_hschr2341
uniprot id: A0A125RDX2
names: Subunit
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

45286:AW171 hschr74022
gene id: 45286:AW171_hschr74022
uniprot id: A0A109V051
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Component of the GINS complex.
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.

45286:AW171 hschr53314
gene id: 45286:AW171_hschr53314
uniprot id: A0A0X8HTV8
names: Similarity
messages: Belongs to the protein kinase superfamily.

45286:AW171 hschr84814
gene id: 45286:AW171_hschr84814
uniprot id: A0A0X8HWL2
names: Function
names: Similarity
messages: Belongs to the heat shock protein 70 family.
messages: Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.

45286:AW171 hschr63571
gene id: 45286:AW171_hschr63571
uniprot id: A0A0X8HUE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF1 family.
messages: nucleolus

45286:AW171 hschr42780
gene id: 45286:AW171_hschr42780
uniprot id: A0A0X8HSW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family. IMP2 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr74230
gene id: 45286:AW171_hschr74230
uniprot id: A0A0X8HVD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

45286:AW171 hschr2215
gene id: 45286:AW171_hschr2215
uniprot id: A0A109UW70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LTN1 family.
messages: Component of the ribosome quality control complex (RQC).
messages: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
messages: cytosol

45286:AW171 hschr42077
gene id: 45286:AW171_hschr42077
uniprot id: A0A0X8HRL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 14 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

45286:AW171 hschr53033
gene id: 45286:AW171_hschr53033
uniprot id: A0A0X8HTB9
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.

45286:AW171 hschr84535
gene id: 45286:AW171_hschr84535
uniprot id: A0A0X8HVX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFH5 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane
messages: Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses.

45286:AW171 hschr42614
gene id: 45286:AW171_hschr42614
uniprot id: A0A0X8HSI5
names: Subcellular Location Annotation
messages: Nucleus membrane

45286:AW171 hschr52941
gene id: 45286:AW171_hschr52941
uniprot id: A0A0X8HT97
names: Similarity
messages: Belongs to the multicopper oxidase family.

45286:AW171 hschr84615
gene id: 45286:AW171_hschr84615
uniprot id: A0A0X8HW26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.
messages: Belongs to the TRM44 family.
messages: Cytoplasm

45286:AW171 hschr84701
gene id: 45286:AW171_hschr84701
uniprot id: A0A109V0A8
names: Similarity
messages: Belongs to the PP2C family.

45286:AW171 hschr31863
gene id: 45286:AW171_hschr31863
uniprot id: A0A109UYK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

45286:AW171 hschr63619
gene id: 45286:AW171_hschr63619
uniprot id: A0A0X8HUE1
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.

45286:AW171 hschr63810
gene id: 45286:AW171_hschr63810
uniprot id: A0A0X8HUV9
names: Subcellular Location Annotation
messages: Cytoplasm

45286:AW171 hschr2461
gene id: 45286:AW171_hschr2461
uniprot id: A0A109UWN2
names: Similarity
messages: Belongs to the FMO family.

45286:AW171 hschr42790
gene id: 45286:AW171_hschr42790
uniprot id: A0A0X8HSU1
names: Similarity
messages: Belongs to the NDK family.

45286:AW171 hschr42710
gene id: 45286:AW171_hschr42710
uniprot id: A0A109UZT0
names: Function
names: Similarity
messages: Belongs to the VPS28 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.

45286:AW171 hschr74079
gene id: 45286:AW171_hschr74079
uniprot id: A0A0X8HV50
names: Similarity
messages: Belongs to the type-1 OGG1 family.

45286:AW171 hschr74253
gene id: 45286:AW171_hschr74253
uniprot id: A0A0X8HVE7
names: Similarity
messages: Belongs to the MYG1 family.

45286:AW171 hschr53302
gene id: 45286:AW171_hschr53302
uniprot id: A0A0X8HTV4
names: Function
messages: Delta(8)-fatty-acid desaturase which introduces a double bond at the 8-position in the long-chain base (LCB) of ceramides. Required for the formation of the di-unsaturated sphingoid base (E,E)-sphinga-4,8-dienine during glucosylceramide (GluCer) biosynthesis.

45286:AW171 hschr31614
gene id: 45286:AW171_hschr31614
uniprot id: A0A109UYF9
names: Similarity
messages: Belongs to the peptidase C13 family.

45286:AW171 hschr31937
gene id: 45286:AW171_hschr31937
uniprot id: A0A0X8HRF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

45286:AW171 hschr2254
gene id: 45286:AW171_hschr2254
uniprot id: A0A109UW97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PCNA family.
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

45286:AW171 hschr63878
gene id: 45286:AW171_hschr63878
uniprot id: A0A109V068
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.

45286:AW171 hschr31428
gene id: 45286:AW171_hschr31428
uniprot id: A0A109UXY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

45286:AW171 hschr74412
gene id: 45286:AW171_hschr74412
uniprot id: A0A0X8HVS3
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr74256
gene id: 45286:AW171_hschr74256
uniprot id: A0A109UY35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB5 family.
messages: Component of the 7-subunit TFIIH core complex.
messages: In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
messages: Nucleus

45286:AW171 hschr74042
gene id: 45286:AW171_hschr74042
uniprot id: A0A0X8HV10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Membrane

45286:AW171 hschr42591
gene id: 45286:AW171_hschr42591
uniprot id: A0A120K279
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

45286:AW171 hschr2229
gene id: 45286:AW171_hschr2229
uniprot id: A0A109UWD3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

45286:AW171 hschr42675
gene id: 45286:AW171_hschr42675
uniprot id: A0A109UX47
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
messages: Cytoplasm
messages: Nucleus

45286:AW171 hschr21268
gene id: 45286:AW171_hschr21268
uniprot id: A0A109UXP3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

45286:AW171 hschr2476
gene id: 45286:AW171_hschr2476
uniprot id: A0A109UWP2
names: Similarity
messages: Belongs to the LCL2 family.

45286:AW171 hschr218
gene id: 45286:AW171_hschr218
uniprot id: A0A109UVX1
names: Similarity
messages: Belongs to the VPS52 family.

45286:AW171 hschr53189
gene id: 45286:AW171_hschr53189
uniprot id: A0A0X8HTL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferredoxin--NADP reductase type 1 family.
messages: Mitochondrion

45286:AW171 hschr2484
gene id: 45286:AW171_hschr2484
uniprot id: A0A109UWT0
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.

45286:AW171 hschr74126
gene id: 45286:AW171_hschr74126
uniprot id: A0A0X8HV79
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr42726
gene id: 45286:AW171_hschr42726
uniprot id: A0A0X8HSU0
names: Function
names: Similarity
messages: Belongs to the GPI family.
messages: In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.

45286:AW171 hschr53350
gene id: 45286:AW171_hschr53350
uniprot id: A0A0X8HTW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.
messages: Cytoplasm

45286:AW171 hschr84853
gene id: 45286:AW171_hschr84853
uniprot id: A0A0X8HWK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

45286:AW171 hschr63618
gene id: 45286:AW171_hschr63618
uniprot id: A0A0X8HUH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

45286:AW171 hschr21111
gene id: 45286:AW171_hschr21111
uniprot id: A0A109UXE3
names: Subcellular Location Annotation
messages: nuclear pore complex

45286:AW171 hschr31693
gene id: 45286:AW171_hschr31693
uniprot id: A0A109UWG8
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr2828
gene id: 45286:AW171_hschr2828
uniprot id: A0A120K149
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS35 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

45286:AW171 hschr74315
gene id: 45286:AW171_hschr74315
uniprot id: A0A0X8HVH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Peroxisome

45286:AW171 hschr42731
gene id: 45286:AW171_hschr42731
uniprot id: A0A0X8HSV1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

45286:AW171 hschr210
gene id: 45286:AW171_hschr210
uniprot id: A0A109UWA1
names: Function
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.
messages: Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.

45286:AW171 hschr84498
gene id: 45286:AW171_hschr84498
uniprot id: A0A109V091
names: Similarity
messages: Belongs to the peptidase A1 family.

45286:AW171 hschr42377
gene id: 45286:AW171_hschr42377
uniprot id: A0A0X8HS83
names: Similarity
messages: Belongs to the cyclin family.

45286:AW171 hschr74409
gene id: 45286:AW171_hschr74409
uniprot id: A0A0X8HVU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.
messages: Cytoplasm
messages: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.

45286:AW171 hschr32031
gene id: 45286:AW171_hschr32031
uniprot id: A0A0X8HRL8
names: Similarity
messages: Belongs to the SGT family.

45286:AW171 hschr42288
gene id: 45286:AW171_hschr42288
uniprot id: A0A0X8HR03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane

45286:AW171 hschr53288
gene id: 45286:AW171_hschr53288
uniprot id: A0A0X8HT35
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr2188
gene id: 45286:AW171_hschr2188
uniprot id: A0A120K0U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ELP2 family.
messages: Cytoplasm
messages: Nucleus

45286:AW171 hschr84688
gene id: 45286:AW171_hschr84688
uniprot id: A0A109UYH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.
messages: spindle

45286:AW171 hschr63942
gene id: 45286:AW171_hschr63942
uniprot id: A0A120K2L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr32040
gene id: 45286:AW171_hschr32040
uniprot id: A0A109UZE4
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.

45286:AW171 hschr85050
gene id: 45286:AW171_hschr85050
uniprot id: A0A0X8HWU4
names: Similarity
messages: Belongs to the eIF-2B gamma/epsilon subunits family.

45286:AW171 hschr85074
gene id: 45286:AW171_hschr85074
uniprot id: A0A0X8HWV2
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

45286:AW171 hschr53414
gene id: 45286:AW171_hschr53414
uniprot id: A0A109UZF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Sterol O-acyltransferase that catalyzes the formation of stery esters.

45286:AW171 hschr31753
gene id: 45286:AW171_hschr31753
uniprot id: A0A109UYK2
names: Subcellular Location Annotation
messages: Cytoplasm

45286:AW171 hschr32037
gene id: 45286:AW171_hschr32037
uniprot id: A0A120K221
names: Subcellular Location Annotation
messages: nucleolus

45286:AW171 hschr84796
gene id: 45286:AW171_hschr84796
uniprot id: A0A109V0S1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Cytoplasm

45286:AW171 hschr42588
gene id: 45286:AW171_hschr42588
uniprot id: A0A109UZ14
names: Similarity
messages: Belongs to the taffazin family.

45286:AW171 hschr42635
gene id: 45286:AW171_hschr42635
uniprot id: A0A109UZ25
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

45286:AW171 hschr2928
gene id: 45286:AW171_hschr2928
uniprot id: A0A125RE11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMP46 family.
messages: Mitochondrion
messages: Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.

45286:AW171 hschr2355
gene id: 45286:AW171_hschr2355
uniprot id: A0A109UWL7
names: Similarity
messages: Belongs to the OPI10 family.

45286:AW171 hschr42397
gene id: 45286:AW171_hschr42397
uniprot id: A0A0X8HS74
names: Similarity
messages: Belongs to the frataxin family.

45286:AW171 hschr84616
gene id: 45286:AW171_hschr84616
uniprot id: A0A0X8HW18
names: Similarity
messages: Belongs to the protein kinase superfamily.

45286:AW171 hschr21253
gene id: 45286:AW171_hschr21253
uniprot id: A0A109UXM7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex.
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr2116
gene id: 45286:AW171_hschr2116
uniprot id: A0A109UW62
names: Similarity
messages: Belongs to the KRI1 family.

45286:AW171 hschr42076
gene id: 45286:AW171_hschr42076
uniprot id: A0A120K222
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YSP2 family.
messages: Membrane

45286:AW171 hschr2486
gene id: 45286:AW171_hschr2486
uniprot id: A0A109UWP9
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Nucleus

45286:AW171 hschr53377
gene id: 45286:AW171_hschr53377
uniprot id: A0A0X8HTW3
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

45286:AW171 hschr53313
gene id: 45286:AW171_hschr53313
uniprot id: A0A120K2F3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

45286:AW171 hschr85076
gene id: 45286:AW171_hschr85076
uniprot id: A0A0X8HX04
names: Similarity
messages: Belongs to the pantothenate synthetase family.

45286:AW171 hschr42738
gene id: 45286:AW171_hschr42738
uniprot id: A0A120K294
names: Similarity
messages: Belongs to the SEN54 family.

45286:AW171 hschr74101
gene id: 45286:AW171_hschr74101
uniprot id: A0A0X8HUP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMG-CoA reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr2451
gene id: 45286:AW171_hschr2451
uniprot id: A0A109UWT2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

45286:AW171 hschr84500
gene id: 45286:AW171_hschr84500
uniprot id: A0A109V0U5
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr63817
gene id: 45286:AW171_hschr63817
uniprot id: A0A0X8HUN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 48 family.
messages: Membrane

45286:AW171 hschr84894
gene id: 45286:AW171_hschr84894
uniprot id: A0A0X8HWQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

45286:AW171 hschr52927
gene id: 45286:AW171_hschr52927
uniprot id: A0A0X8HT58
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

45286:AW171 hschr53130
gene id: 45286:AW171_hschr53130
uniprot id: A0A109UZF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B1 family.
messages: Nucleus

45286:AW171 hschr63792
gene id: 45286:AW171_hschr63792
uniprot id: A0A0X8HUU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Mitochondrion

45286:AW171 hschr2456
gene id: 45286:AW171_hschr2456
uniprot id: A0A109UWN8
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr63705
gene id: 45286:AW171_hschr63705
uniprot id: A0A0X8HUI2
names: Similarity
messages: Belongs to the Luc7 family.

45286:AW171 hschr31775
gene id: 45286:AW171_hschr31775
uniprot id: A0A0X8HR67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP1/IKA1 family.
messages: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
messages: Cytoplasm
messages: Nucleus

45286:AW171 hschr2957
gene id: 45286:AW171_hschr2957
uniprot id: A0A120K189
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

45286:AW171 hschr2221
gene id: 45286:AW171_hschr2221
uniprot id: A0A120K0V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPS2 family.
messages: Cell membrane
messages: Membrane

45286:AW171 hschr2389
gene id: 45286:AW171_hschr2389
uniprot id: A0A109UX04
names: Function
messages: Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).

45286:AW171 hschr74425
gene id: 45286:AW171_hschr74425
uniprot id: A0A0X8HVS6
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr42638
gene id: 45286:AW171_hschr42638
uniprot id: A0A120K282
names: Similarity
messages: Belongs to the proteasome subunit p27 family.

45286:AW171 hschr31387
gene id: 45286:AW171_hschr31387
uniprot id: A0A120K1M7
names: Similarity
messages: Belongs to the IST1 family.

45286:AW171 hschr31364
gene id: 45286:AW171_hschr31364
uniprot id: A0A109UXT7
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr2937
gene id: 45286:AW171_hschr2937
uniprot id: A0A120K188
names: Similarity
messages: In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.

45286:AW171 hschr31524
gene id: 45286:AW171_hschr31524
uniprot id: A0A109UY64
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

45286:AW171 hschr84587
gene id: 45286:AW171_hschr84587
uniprot id: A0A0X8HW68
names: Similarity
messages: Belongs to the PPP phosphatase family.

45286:AW171 hschr74138
gene id: 45286:AW171_hschr74138
uniprot id: A0A120K2N8
names: Function
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.
messages: Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP.

45286:AW171 hschr31593
gene id: 45286:AW171_hschr31593
uniprot id: A0A120K1U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex DAD4 family.
messages: Nucleus
messages: kinetochore
messages: spindle

45286:AW171 hschr63664
gene id: 45286:AW171_hschr63664
uniprot id: A0A0X8HUL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHE9 family.
messages: Homooligomer.
messages: Mitochondrion inner membrane
messages: Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed.

45286:AW171 hschr85055
gene id: 45286:AW171_hschr85055
uniprot id: A0A120K2Y1
names: Similarity
messages: Belongs to the protein kinase superfamily.

45286:AW171 hschr63693
gene id: 45286:AW171_hschr63693
uniprot id: A0A120K2J5
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.

45286:AW171 hschr53180
gene id: 45286:AW171_hschr53180
uniprot id: A0A0X8HTQ2
names: Function
names: Similarity
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes.

45286:AW171 hschr74206
gene id: 45286:AW171_hschr74206
uniprot id: A0A109UZY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

45286:AW171 hschr21071
gene id: 45286:AW171_hschr21071
uniprot id: A0A109UXG0
names: Subcellular Location Annotation
messages: Cytoplasm

45286:AW171 hschr53203
gene id: 45286:AW171_hschr53203
uniprot id: A0A0X8HTP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex SPC34 family.
messages: Nucleus
messages: kinetochore
messages: spindle

45286:AW171 hschr31920
gene id: 45286:AW171_hschr31920
uniprot id: A0A0X8HRE5
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr21220
gene id: 45286:AW171_hschr21220
uniprot id: A0A109UY10
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

45286:AW171 hschr21112
gene id: 45286:AW171_hschr21112
uniprot id: A0A120K1E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL54 family.
messages: Mitochondrion

45286:AW171 hschr53398
gene id: 45286:AW171_hschr53398
uniprot id: A0A0X8HU08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

45286:AW171 hschr42569
gene id: 45286:AW171_hschr42569
uniprot id: A0A0X8HRP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC2 subfamily.
messages: Nucleus

45286:AW171 hschr42536
gene id: 45286:AW171_hschr42536
uniprot id: A0A0X8HSI4
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr2265
gene id: 45286:AW171_hschr2265
uniprot id: A0A120K0W0
names: Similarity
messages: Belongs to the UFD1 family.

45286:AW171 hschr31523
gene id: 45286:AW171_hschr31523
uniprot id: A0A109UYA1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. Eukaryotic subfamily.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

45286:AW171 hschr84579
gene id: 45286:AW171_hschr84579
uniprot id: A0A120K2T3
names: Subcellular Location Annotation
messages: Peroxisome membrane

45286:AW171 hschr42724
gene id: 45286:AW171_hschr42724
uniprot id: A0A109UZ52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGC family.
messages: Membrane

45286:AW171 hschr31748
gene id: 45286:AW171_hschr31748
uniprot id: A0A0X8HQ22
names: Similarity
messages: Belongs to the peptidase C19 family.

45286:AW171 hschr42316
gene id: 45286:AW171_hschr42316
uniprot id: A0A0X8HS65
names: Similarity
messages: Belongs to the PPP4R2 family.

45286:AW171 hschr84512
gene id: 45286:AW171_hschr84512
uniprot id: A0A109V062
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Proteolytically removes the C-terminal three residues of farnesylated proteins.

45286:AW171 hschr84910
gene id: 45286:AW171_hschr84910
uniprot id: A0A0X8HWM3
names: Similarity
messages: Belongs to the BRX1 family.

45286:AW171 hschr84870
gene id: 45286:AW171_hschr84870
uniprot id: A0A0X8HW52
names: Similarity
messages: Belongs to the DNA polymerase delta/II small subunit family.

45286:AW171 hschr84784
gene id: 45286:AW171_hschr84784
uniprot id: A0A0X8HWC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase T2 family.
messages: Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration.
messages: Vacuole lumen

45286:AW171 hschr31813
gene id: 45286:AW171_hschr31813
uniprot id: A0A109UYQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytoskeleton

45286:AW171 hschr31896
gene id: 45286:AW171_hschr31896
uniprot id: A0A109UWN0
names: Similarity
messages: Belongs to the DCC1 family.

45286:AW171 hschr2970
gene id: 45286:AW171_hschr2970
uniprot id: A0A120K1A7
names: Function
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

45286:AW171 hschr53451
gene id: 45286:AW171_hschr53451
uniprot id: A0A0X8HU50
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

45286:AW171 hschr74321
gene id: 45286:AW171_hschr74321
uniprot id: A0A0X8HVS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase F subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.
messages: Vacuole membrane

45286:AW171 hschr42723
gene id: 45286:AW171_hschr42723
uniprot id: A0A109UX53
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

45286:AW171 hschr32011
gene id: 45286:AW171_hschr32011
uniprot id: A0A0X8HRJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

45286:AW171 hschr42820
gene id: 45286:AW171_hschr42820
uniprot id: A0A0X8HT02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

45286:AW171 hschr31495
gene id: 45286:AW171_hschr31495
uniprot id: A0A120K1R2
names: Function
names: Similarity
messages: Belongs to the BLI1 family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.

45286:AW171 hschr63586
gene id: 45286:AW171_hschr63586
uniprot id: A0A0X8HUF9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

45286:AW171 hschr42276
gene id: 45286:AW171_hschr42276
uniprot id: A0A0X8HRZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC4 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication.
messages: Nucleus

45286:AW171 hschr53175
gene id: 45286:AW171_hschr53175
uniprot id: A0A120K2D8
names: Similarity
messages: Belongs to the MIX23 family.

45286:AW171 hschr84551
gene id: 45286:AW171_hschr84551
uniprot id: A0A109V0V5
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr42393
gene id: 45286:AW171_hschr42393
uniprot id: A0A0X8HS69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: Membrane
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.
messages: Mitochondrion inner membrane

45286:AW171 hschr42562
gene id: 45286:AW171_hschr42562
uniprot id: A0A0X8HSJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

45286:AW171 hschr2438
gene id: 45286:AW171_hschr2438
uniprot id: A0A109UWL2
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

45286:AW171 hschr84850
gene id: 45286:AW171_hschr84850
uniprot id: A0A0X8HWG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr21101
gene id: 45286:AW171_hschr21101
uniprot id: A0A120K1D5
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

45286:AW171 hschr42282
gene id: 45286:AW171_hschr42282
uniprot id: A0A0X8HS16
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

45286:AW171 hschr63717
gene id: 45286:AW171_hschr63717
uniprot id: A0A0X8HTW4
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

45286:AW171 hschr63853
gene id: 45286:AW171_hschr63853
uniprot id: A0A0X8HU44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: Homohexamer or homoheptamer. Organized in a ring with a central cavity.
messages: Mitochondrion matrix

45286:AW171 hschr2891
gene id: 45286:AW171_hschr2891
uniprot id: A0A120K182
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYSTM1 family.
messages: Membrane

45286:AW171 hschr53172
gene id: 45286:AW171_hschr53172
uniprot id: A0A0X8HTM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM24 family.
messages: Mitochondrion

45286:AW171 hschr63795
gene id: 45286:AW171_hschr63795
uniprot id: A0A0X8HUU9
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr53194
gene id: 45286:AW171_hschr53194
uniprot id: A0A0X8HTP0
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

45286:AW171 hschr53256
gene id: 45286:AW171_hschr53256
uniprot id: A0A0X8HTS0
names: Similarity
messages: Belongs to the glutathione peroxidase family.

45286:AW171 hschr21113
gene id: 45286:AW171_hschr21113
uniprot id: A0A120K1E3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.
messages: Membrane

45286:AW171 hschr42302
gene id: 45286:AW171_hschr42302
uniprot id: A0A0X8HS32
names: Similarity
messages: Belongs to the peptidase S10 family.

45286:AW171 hschr53199
gene id: 45286:AW171_hschr53199
uniprot id: A0A0X8HTP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr42831
gene id: 45286:AW171_hschr42831
uniprot id: A0A0X8HSZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr227
gene id: 45286:AW171_hschr227
uniprot id: A0A120K0N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 85 family.
messages: cytosol

45286:AW171 hschr31923
gene id: 45286:AW171_hschr31923
uniprot id: A0A109UYM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr53131
gene id: 45286:AW171_hschr53131
uniprot id: A0A109UXD5
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

45286:AW171 hschr84958
gene id: 45286:AW171_hschr84958
uniprot id: A0A0X8HWN7
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

45286:AW171 hschr42146
gene id: 45286:AW171_hschr42146
uniprot id: A0A0X8HQS7
names: Similarity
messages: Belongs to the acetyltransferase family. GNA1 subfamily.

45286:AW171 hschr272
gene id: 45286:AW171_hschr272
uniprot id: A0A109UVX7
names: Similarity
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.

45286:AW171 hschr2130
gene id: 45286:AW171_hschr2130
uniprot id: A0A125RDU5
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr74125
gene id: 45286:AW171_hschr74125
uniprot id: A0A109V0B8
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

45286:AW171 hschr63720
gene id: 45286:AW171_hschr63720
uniprot id: A0A0X8HUI4
names: Similarity
messages: Belongs to the SIP5 family.

45286:AW171 hschr52986
gene id: 45286:AW171_hschr52986
uniprot id: A0A0X8HTC7
names: Subcellular Location Annotation
messages: Cytoplasm

45286:AW171 hschr31365
gene id: 45286:AW171_hschr31365
uniprot id: A0A109UYA3
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

45286:AW171 hschr42205
gene id: 45286:AW171_hschr42205
uniprot id: A0A0X8HRZ5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Heterooctamer of 4 alpha and 4 beta chains.

45286:AW171 hschr63945
gene id: 45286:AW171_hschr63945
uniprot id: A0A120K2L9
names: Similarity
messages: Belongs to the CBF/MAK21 family.

45286:AW171 hschr2396
gene id: 45286:AW171_hschr2396
uniprot id: A0A109UWJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku80 family.
messages: Nucleus
messages: telomere

45286:AW171 hschr84589
gene id: 45286:AW171_hschr84589
uniprot id: A0A0X8HW30
names: Similarity
messages: In the C-terminal section; belongs to the anthranilate synthase component I family.

45286:AW171 hschr42111
gene id: 45286:AW171_hschr42111
uniprot id: A0A0X8HRN9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

45286:AW171 hschr63518
gene id: 45286:AW171_hschr63518
uniprot id: A0A0X8HU93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck

45286:AW171 hschr42720
gene id: 45286:AW171_hschr42720
uniprot id: A0A109UZB1
names: Similarity
messages: Belongs to the peptidase C19 family.

45286:AW171 hschr63902
gene id: 45286:AW171_hschr63902
uniprot id: A0A0X8HU76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290). In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.
messages: Cytoplasm

45286:AW171 hschr53171
gene id: 45286:AW171_hschr53171
uniprot id: A0A0X8HSW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF6 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
messages: Component of the NuA4 histone acetyltransferase complex.
messages: Nucleus

45286:AW171 hschr63976
gene id: 45286:AW171_hschr63976
uniprot id: A0A109UZX4
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr74048
gene id: 45286:AW171_hschr74048
uniprot id: A0A0X8HVA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunit 4 family.
messages: centrosome
messages: sarcomere
messages: stress fiber

45286:AW171 hschr84811
gene id: 45286:AW171_hschr84811
uniprot id: A0A120K2V9
names: Similarity
messages: Belongs to the cyclin family.

45286:AW171 hschr31513
gene id: 45286:AW171_hschr31513
uniprot id: A0A120K1R3
names: Similarity
messages: Belongs to the polyprenol kinase family.

45286:AW171 hschr53456
gene id: 45286:AW171_hschr53456
uniprot id: A0A0X8HU61
names: Subcellular Location Annotation
messages: Chromosome

45286:AW171 hschr53403
gene id: 45286:AW171_hschr53403
uniprot id: A0A120K2G7
names: Similarity
messages: Belongs to the uridine kinase family.

45286:AW171 hschr42221
gene id: 45286:AW171_hschr42221
uniprot id: A0A0X8HS04
names: Similarity
messages: Belongs to the CNOT9 family.

45286:AW171 hschr238
gene id: 45286:AW171_hschr238
uniprot id: A0A125RDT4
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.

45286:AW171 hschr74236
gene id: 45286:AW171_hschr74236
uniprot id: A0A0X8HVG4
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

45286:AW171 hschr42568
gene id: 45286:AW171_hschr42568
uniprot id: A0A0X8HSI0
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

45286:AW171 hschr42787
gene id: 45286:AW171_hschr42787
uniprot id: A0A0X8HSY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcriptional coactivator PC4 family.
messages: Nucleus

45286:AW171 hschr74480
gene id: 45286:AW171_hschr74480
uniprot id: A0A120K2S2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CHZ1 family.
messages: Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.
messages: Nucleus

45286:AW171 hschr84845
gene id: 45286:AW171_hschr84845
uniprot id: A0A109V0H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DCAF13/WDSOF1 family.
messages: nucleolus

45286:AW171 hschr53161
gene id: 45286:AW171_hschr53161
uniprot id: A0A120K2D7
names: Similarity
messages: Belongs to the nucleoporin Nup133 family.

45286:AW171 hschr42509
gene id: 45286:AW171_hschr42509
uniprot id: A0A0X8HSD9
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr84820
gene id: 45286:AW171_hschr84820
uniprot id: A0A0X8HW15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.
messages: nucleolus

45286:AW171 hschr2128
gene id: 45286:AW171_hschr2128
uniprot id: A0A120K0R8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS19 family.

45286:AW171 hschr32032
gene id: 45286:AW171_hschr32032
uniprot id: A0A0X8HRL1
names: Similarity
messages: Belongs to the UPF0507 family.

45286:AW171 hschr2431
gene id: 45286:AW171_hschr2431
uniprot id: A0A120K109
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.

45286:AW171 hschr53062
gene id: 45286:AW171_hschr53062
uniprot id: A0A0X8HTF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

45286:AW171 hschr85034
gene id: 45286:AW171_hschr85034
uniprot id: A0A109V0R1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

45286:AW171 hschr53413
gene id: 45286:AW171_hschr53413
uniprot id: A0A0X8HU18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.
messages: Cytoplasm
messages: Nucleus

45286:AW171 hschr31345
gene id: 45286:AW171_hschr31345
uniprot id: A0A109UYI9
names: Similarity
messages: Belongs to the RRP7 family.

45286:AW171 hschr84926
gene id: 45286:AW171_hschr84926
uniprot id: A0A0X8HWL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Nucleus

45286:AW171 hschr242
gene id: 45286:AW171_hschr242
uniprot id: A0A109UVX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT4 family.
messages: Nucleus
messages: The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.
messages: centromere

45286:AW171 hschr63851
gene id: 45286:AW171_hschr63851
uniprot id: A0A0X8HUW4
names: Similarity
messages: Belongs to the DDI1 family.

45286:AW171 hschr42392
gene id: 45286:AW171_hschr42392
uniprot id: A0A0X8HS89
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

45286:AW171 hschr31604
gene id: 45286:AW171_hschr31604
uniprot id: A0A109UY91
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr84998
gene id: 45286:AW171_hschr84998
uniprot id: A0A0X8HWU8
names: Similarity
messages: Belongs to the CWC22 family.

45286:AW171 hschr42243
gene id: 45286:AW171_hschr42243
uniprot id: A0A0X8HRW9
names: Similarity
messages: Belongs to the PGA52 family.

45286:AW171 hschr2449
gene id: 45286:AW171_hschr2449
uniprot id: A0A125RDY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Nucleus

45286:AW171 hschr2862
gene id: 45286:AW171_hschr2862
uniprot id: A0A120K164
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

45286:AW171 hschr74143
gene id: 45286:AW171_hschr74143
uniprot id: A0A0X8HVG0
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr2946
gene id: 45286:AW171_hschr2946
uniprot id: A0A109UX55
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

45286:AW171 hschr31713
gene id: 45286:AW171_hschr31713
uniprot id: A0A120K1X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
messages: Nucleus

45286:AW171 hschr42095
gene id: 45286:AW171_hschr42095
uniprot id: A0A0X8HRQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMCO4 family.
messages: Membrane

45286:AW171 hschr84768
gene id: 45286:AW171_hschr84768
uniprot id: A0A0X8HWD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the activator 1 large subunit family.
messages: Nucleus

45286:AW171 hschr42360
gene id: 45286:AW171_hschr42360
uniprot id: A0A0X8HS27
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm

45286:AW171 hschr52938
gene id: 45286:AW171_hschr52938
uniprot id: A0A0X8HT32
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NMT1/THI5 family.
messages: Homodimer.
messages: Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.

45286:AW171 hschr31431
gene id: 45286:AW171_hschr31431
uniprot id: A0A120K1Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

45286:AW171 hschr53127
gene id: 45286:AW171_hschr53127
uniprot id: A0A109UZ99
names: Similarity
messages: Belongs to the WD repeat RAPTOR family.

45286:AW171 hschr74470
gene id: 45286:AW171_hschr74470
uniprot id: A0A0X8HVZ7
names: Similarity
messages: Belongs to the BolA/IbaG family.

45286:AW171 hschr63669
gene id: 45286:AW171_hschr63669
uniprot id: A0A0X8HUG6
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr31715
gene id: 45286:AW171_hschr31715
uniprot id: A0A120K1X9
names: Subcellular Location Annotation
messages: Vacuole

45286:AW171 hschr21132
gene id: 45286:AW171_hschr21132
uniprot id: A0A120K1E8
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

45286:AW171 hschr2512
gene id: 45286:AW171_hschr2512
uniprot id: A0A125RDZ3
names: Similarity
messages: Belongs to the VPS37 family.

45286:AW171 hschr42101
gene id: 45286:AW171_hschr42101
uniprot id: A0A0X8HRQ6
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

45286:AW171 hschr2435
gene id: 45286:AW171_hschr2435
uniprot id: A0A109UWS0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

45286:AW171 hschr42697
gene id: 45286:AW171_hschr42697
uniprot id: A0A0X8HSR9
names: Similarity
messages: Belongs to the protein kinase superfamily.

45286:AW171 hschr63952
gene id: 45286:AW171_hschr63952
uniprot id: A0A0X8HV37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A, B and F subunits.

45286:AW171 hschr63935
gene id: 45286:AW171_hschr63935
uniprot id: A0A0X8HV27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Mitochondrion inner membrane
messages: Probably involved in the biogenesis of the COX complex.

45286:AW171 hschr74257
gene id: 45286:AW171_hschr74257
uniprot id: A0A109V0P7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS41 family.
messages: Required for vacuolar assembly and vacuolar traffic.
messages: Vacuole

45286:AW171 hschr31804
gene id: 45286:AW171_hschr31804
uniprot id: A0A0X8HR77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRE1 family.
messages: Nucleus

45286:AW171 hschr74408
gene id: 45286:AW171_hschr74408
uniprot id: A0A0X8HVV9
names: Similarity
messages: Belongs to the universal ribosomal protein uS10 family.

45286:AW171 hschr63898
gene id: 45286:AW171_hschr63898
uniprot id: A0A0X8HUS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPAP2 family.
messages: Nucleus
messages: Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.

45286:AW171 hschr31650
gene id: 45286:AW171_hschr31650
uniprot id: A0A109UYR9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H3 family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

45286:AW171 hschr84687
gene id: 45286:AW171_hschr84687
uniprot id: A0A109V0D9
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

45286:AW171 hschr84746
gene id: 45286:AW171_hschr84746
uniprot id: A0A109V0B9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAD18 family.
messages: E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.
messages: Interacts with E2 UBC2, forming a complex with ubiquitin ligase activity.
messages: Nucleus

45286:AW171 hschr63900
gene id: 45286:AW171_hschr63900
uniprot id: A0A0X8HUZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
messages: Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
messages: Mitochondrion

45286:AW171 hschr53337
gene id: 45286:AW171_hschr53337
uniprot id: A0A0X8HTX3
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

45286:AW171 hschr42772
gene id: 45286:AW171_hschr42772
uniprot id: A0A0X8HSX0
names: Similarity
messages: Belongs to the TRIAP1/MDM35 family.

45286:AW171 hschr217
gene id: 45286:AW171_hschr217
uniprot id: A0A120K0N2
names: Similarity
messages: Belongs to the activator 1 small subunits family.

45286:AW171 hschr31835
gene id: 45286:AW171_hschr31835
uniprot id: A0A0X8HR97
names: Similarity
messages: Belongs to the CDC73 family.

45286:AW171 hschr63523
gene id: 45286:AW171_hschr63523
uniprot id: A0A0X8HU71
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr53387
gene id: 45286:AW171_hschr53387
uniprot id: A0A109UXJ8
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr53239
gene id: 45286:AW171_hschr53239
uniprot id: A0A0X8HTP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

45286:AW171 hschr2100
gene id: 45286:AW171_hschr2100
uniprot id: A0A109UWS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Membrane

45286:AW171 hschr84664
gene id: 45286:AW171_hschr84664
uniprot id: A0A0X8HWA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-3' exonuclease family.
messages: Cytoplasm
messages: Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.

45286:AW171 hschr63653
gene id: 45286:AW171_hschr63653
uniprot id: A0A0X8HUJ8
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

45286:AW171 hschr74310
gene id: 45286:AW171_hschr74310
uniprot id: A0A0X8HVP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr42382
gene id: 45286:AW171_hschr42382
uniprot id: A0A0X8HS61
names: Similarity
messages: Belongs to the proteasome subunit p55 family.

45286:AW171 hschr63870
gene id: 45286:AW171_hschr63870
uniprot id: A0A109V013
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

45286:AW171 hschr42378
gene id: 45286:AW171_hschr42378
uniprot id: A0A0X8HS60
names: Similarity
messages: Belongs to the SAS10 family.

45286:AW171 hschr53183
gene id: 45286:AW171_hschr53183
uniprot id: A0A0X8HTQ9
names: Similarity
messages: Belongs to the DEAD box helicase family.

45286:AW171 hschr42399
gene id: 45286:AW171_hschr42399
uniprot id: A0A120K258
names: Similarity
messages: Belongs to the peptidase C19 family.

45286:AW171 hschr42108
gene id: 45286:AW171_hschr42108
uniprot id: A0A0X8HRP3
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B family.

45286:AW171 hschr63628
gene id: 45286:AW171_hschr63628
uniprot id: A0A109UZQ0
names: Function
names: PTM
names: Similarity
messages: Belongs to the eIF-5A family.
messages: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.

45286:AW171 hschr53299
gene id: 45286:AW171_hschr53299
uniprot id: A0A0X8HTV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 3 (AP-3) is a heterotetramer.
messages: Belongs to the adaptor complexes large subunit family.
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.

45286:AW171 hschr31843
gene id: 45286:AW171_hschr31843
uniprot id: A0A0X8HQ89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDA2 family.
messages: Cell projection
messages: Cytoplasm

45286:AW171 hschr63816
gene id: 45286:AW171_hschr63816
uniprot id: A0A109V002
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Membrane
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.

45286:AW171 hschr84940
gene id: 45286:AW171_hschr84940
uniprot id: A0A0X8HWU6
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

45286:AW171 hschr84875
gene id: 45286:AW171_hschr84875
uniprot id: A0A109V0H7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

45286:AW171 hschr31665
gene id: 45286:AW171_hschr31665
uniprot id: A0A109UYT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosyl-DNA phosphodiesterase family.
messages: Nucleus

45286:AW171 hschr74299
gene id: 45286:AW171_hschr74299
uniprot id: A0A109V005
names: Similarity
messages: Belongs to the cytochrome b5 family.

45286:AW171 hschr84736
gene id: 45286:AW171_hschr84736
uniprot id: A0A0X8HWG5
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.

45286:AW171 hschr53297
gene id: 45286:AW171_hschr53297
uniprot id: A0A0X8HTU9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr21048
gene id: 45286:AW171_hschr21048
uniprot id: A0A120K1D2
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

45286:AW171 hschr295
gene id: 45286:AW171_hschr295
uniprot id: A0A120K0Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck.
messages: Self-associates. Interacts with NDL1 and dynein.
messages: cytoskeleton
messages: spindle pole

45286:AW171 hschr31376
gene id: 45286:AW171_hschr31376
uniprot id: A0A109UY08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF2 family.
messages: Nucleus

45286:AW171 hschr2151
gene id: 45286:AW171_hschr2151
uniprot id: A0A109UWJ1
names: Subcellular Location Annotation
messages: Peroxisome membrane

45286:AW171 hschr21213
gene id: 45286:AW171_hschr21213
uniprot id: A0A109UXN3
names: Function
names: Similarity
messages: Belongs to the endosulfine family.
messages: Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.

45286:AW171 hschr63781
gene id: 45286:AW171_hschr63781
uniprot id: A0A0X8HU00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

45286:AW171 hschr53195
gene id: 45286:AW171_hschr53195
uniprot id: A0A0X8HTR2
names: Similarity
messages: In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.

45286:AW171 hschr2226
gene id: 45286:AW171_hschr2226
uniprot id: A0A125RDV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OS-9 family.
messages: Endoplasmic reticulum membrane
messages: Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.

45286:AW171 hschr31442
gene id: 45286:AW171_hschr31442
uniprot id: A0A109UYD6
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

45286:AW171 hschr63871
gene id: 45286:AW171_hschr63871
uniprot id: A0A0X8HUR1
names: Similarity
messages: Belongs to the heat shock protein 70 family.

45286:AW171 hschr84848
gene id: 45286:AW171_hschr84848
uniprot id: A0A0X8HWM8
names: Similarity
messages: Belongs to the SDO1/SBDS family.

45286:AW171 hschr63596
gene id: 45286:AW171_hschr63596
uniprot id: A0A120K2I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr53211
gene id: 45286:AW171_hschr53211
uniprot id: A0A120K2E5
names: Similarity
messages: Belongs to the ATPase epsilon chain family.

45286:AW171 hschr31360
gene id: 45286:AW171_hschr31360
uniprot id: A0A109UYK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTA1 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

45286:AW171 hschr31972
gene id: 45286:AW171_hschr31972
uniprot id: A0A120K213
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr31687
gene id: 45286:AW171_hschr31687
uniprot id: A0A120K1X2
names: Function
names: Similarity
messages: Belongs to the peptidase T1A family.
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

45286:AW171 hschr2399
gene id: 45286:AW171_hschr2399
uniprot id: A0A125RDX9
names: Similarity
messages: Belongs to the RRN3 family.

45286:AW171 hschr85067
gene id: 45286:AW171_hschr85067
uniprot id: A0A120K2Y6
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

45286:AW171 hschr290
gene id: 45286:AW171_hschr290
uniprot id: A0A109UW07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.
messages: Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

45286:AW171 hschr84751
gene id: 45286:AW171_hschr84751
uniprot id: A0A0X8HWB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 48 family.
messages: Membrane

45286:AW171 hschr31546
gene id: 45286:AW171_hschr31546
uniprot id: A0A120K1U0
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.

45286:AW171 hschr84947
gene id: 45286:AW171_hschr84947
uniprot id: A0A0X8HWS0
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.

45286:AW171 hschr2516
gene id: 45286:AW171_hschr2516
uniprot id: A0A125RDZ4
names: Similarity
messages: Belongs to the peptidase A1 family.

45286:AW171 hschr84841
gene id: 45286:AW171_hschr84841
uniprot id: A0A109V0M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

45286:AW171 hschr21116
gene id: 45286:AW171_hschr21116
uniprot id: A0A109UXE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COA3 family.
messages: Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.
messages: Membrane
messages: Required for assembly of cytochrome c oxidase (complex IV).

45286:AW171 hschr74295
gene id: 45286:AW171_hschr74295
uniprot id: A0A0X8HVN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

45286:AW171 hschr31322
gene id: 45286:AW171_hschr31322
uniprot id: A0A120K1K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRE28 family.
messages: Involved in kinetochore-microtubule binding and the spindle assembly checkpoint.
messages: Nucleus membrane
messages: kinetochore
messages: spindle pole body

45286:AW171 hschr2498
gene id: 45286:AW171_hschr2498
uniprot id: A0A109UWW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

45286:AW171 hschr42758
gene id: 45286:AW171_hschr42758
uniprot id: A0A0X8HSX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP4 family.
messages: Cytoplasm
messages: Nucleus

45286:AW171 hschr21024
gene id: 45286:AW171_hschr21024
uniprot id: A0A109UXD0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

45286:AW171 hschr42214
gene id: 45286:AW171_hschr42214
uniprot id: A0A120K240
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERF4 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with ERF2.

45286:AW171 hschr63883
gene id: 45286:AW171_hschr63883
uniprot id: A0A0X8HUZ7
names: Similarity
messages: Belongs to the Clp1 family. NOL9/GRC3 subfamily.

45286:AW171 hschr226
gene id: 45286:AW171_hschr226
uniprot id: A0A109UVW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Membrane

45286:AW171 hschr2227
gene id: 45286:AW171_hschr2227
uniprot id: A0A109UX09
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr42229
gene id: 45286:AW171_hschr42229
uniprot id: A0A120K241
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GON7 family.
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
messages: Nucleus

45286:AW171 hschr2309
gene id: 45286:AW171_hschr2309
uniprot id: A0A109UWV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG14 family.
messages: Membrane
messages: Vacuole membrane

45286:AW171 hschr2288
gene id: 45286:AW171_hschr2288
uniprot id: A0A125RDW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least SUS1, SAC3, THP1, SEM1, and CDC31. TREX-2 contains 2 SUS1 chains. The TREX-2 complex interacts with the nucleoporin NUP1. Component of the 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5 distinct domains with specialized functions. Within the SAGA complex, SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with THP1, SAC3, SGF11, and with the RNA polymerase II.
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. May also be involved in cytoplasmic mRNA decay by interaction with components of P-bodies.
messages: P-body
messages: nucleoplasm

45286:AW171 hschr85026
gene id: 45286:AW171_hschr85026
uniprot id: A0A0X8HWZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

45286:AW171 hschr31952
gene id: 45286:AW171_hschr31952
uniprot id: A0A0X8HRG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

45286:AW171 hschr258
gene id: 45286:AW171_hschr258
uniprot id: A0A109UVY8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

45286:AW171 hschr31597
gene id: 45286:AW171_hschr31597
uniprot id: A0A109UWB0
names: Function
names: Similarity
messages: Belongs to the AB hydrolase superfamily.
messages: Demethylates proteins that have been reversibly carboxymethylated.

45286:AW171 hschr31569
gene id: 45286:AW171_hschr31569
uniprot id: A0A109UY88
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

45286:AW171 hschr21052
gene id: 45286:AW171_hschr21052
uniprot id: A0A109UXD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB1 family.
messages: Nucleus

45286:AW171 hschr74424
gene id: 45286:AW171_hschr74424
uniprot id: A0A0X8HVV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKZF1/VMS1 family.
messages: Cytoplasm

45286:AW171 hschr63709
gene id: 45286:AW171_hschr63709
uniprot id: A0A109V0D5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OSW5 family.
messages: Involved in spore wall assembly.
messages: Membrane

45286:AW171 hschr2356
gene id: 45286:AW171_hschr2356
uniprot id: A0A109UWJ6
names: Similarity
names: Subunit
messages: Belongs to the SIL1 family.
messages: Interacts with KAR2.

45286:AW171 hschr84554
gene id: 45286:AW171_hschr84554
uniprot id: A0A0X8HVZ3
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

45286:AW171 hschr42174
gene id: 45286:AW171_hschr42174
uniprot id: A0A0X8HRX6
names: Function
names: Similarity
messages: Belongs to the PIGL family.
messages: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.

45286:AW171 hschr2978
gene id: 45286:AW171_hschr2978
uniprot id: A0A109UX74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

45286:AW171 hschr31932
gene id: 45286:AW171_hschr31932
uniprot id: A0A0X8HRE2
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

45286:AW171 hschr84591
gene id: 45286:AW171_hschr84591
uniprot id: A0A0X8HW34
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr84635
gene id: 45286:AW171_hschr84635
uniprot id: A0A0X8HVP1
names: Cofactor
names: Similarity
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.

45286:AW171 hschr42144
gene id: 45286:AW171_hschr42144
uniprot id: A0A0X8HRS7
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

45286:AW171 hschr53084
gene id: 45286:AW171_hschr53084
uniprot id: A0A109UZF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

45286:AW171 hschr42130
gene id: 45286:AW171_hschr42130
uniprot id: A0A0X8HRQ8
names: Similarity
messages: Belongs to the MBF1 family.

45286:AW171 hschr42763
gene id: 45286:AW171_hschr42763
uniprot id: A0A0X8HSU8
names: Domain
names: Function
names: Similarity
messages: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.
messages: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

45286:AW171 hschr42369
gene id: 45286:AW171_hschr42369
uniprot id: A0A109UYY9
names: Similarity
messages: Belongs to the cyclin family. Cyclin C subfamily.

45286:AW171 hschr31666
gene id: 45286:AW171_hschr31666
uniprot id: A0A109UYE5
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

45286:AW171 hschr53246
gene id: 45286:AW171_hschr53246
uniprot id: A0A109UZG4
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

45286:AW171 hschr74411
gene id: 45286:AW171_hschr74411
uniprot id: A0A0X8HV98
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr31774
gene id: 45286:AW171_hschr31774
uniprot id: A0A0X8HR45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAD52 family.
messages: Interacts with RAD51 and RAD52.
messages: Involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing. Anneals complementary single-stranded DNA.
messages: Nucleus

45286:AW171 hschr63524
gene id: 45286:AW171_hschr63524
uniprot id: A0A0X8HTK2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
messages: Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

45286:AW171 hschr42566
gene id: 45286:AW171_hschr42566
uniprot id: A0A0X8HSM6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

45286:AW171 hschr42824
gene id: 45286:AW171_hschr42824
uniprot id: A0A0X8HSW4
names: Similarity
messages: Belongs to the SURF6 family.

45286:AW171 hschr21236
gene id: 45286:AW171_hschr21236
uniprot id: A0A109UY20
names: Similarity
messages: Belongs to the APC1 family.

45286:AW171 hschr42491
gene id: 45286:AW171_hschr42491
uniprot id: A0A0X8HSD7
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

45286:AW171 hschr53358
gene id: 45286:AW171_hschr53358
uniprot id: A0A120K2F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

45286:AW171 hschr53461
gene id: 45286:AW171_hschr53461
uniprot id: A0A0X8HU29
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

45286:AW171 hschr31652
gene id: 45286:AW171_hschr31652
uniprot id: A0A120K1V8
names: Similarity
messages: Belongs to the TCP11 family.

45286:AW171 hschr31984
gene id: 45286:AW171_hschr31984
uniprot id: A0A109UYJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Mitochondrion inner membrane

45286:AW171 hschr2317
gene id: 45286:AW171_hschr2317
uniprot id: A0A109UWH3
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr2291
gene id: 45286:AW171_hschr2291
uniprot id: A0A109UWF8
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.

45286:AW171 hschr42362
gene id: 45286:AW171_hschr42362
uniprot id: A0A0X8HS73
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

45286:AW171 hschr21225
gene id: 45286:AW171_hschr21225
uniprot id: A0A120K1I8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

45286:AW171 hschr223
gene id: 45286:AW171_hschr223
uniprot id: A0A125RDT2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

45286:AW171 hschr2479
gene id: 45286:AW171_hschr2479
uniprot id: A0A109UWT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the midasin family.
messages: Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.
messages: nucleolus
messages: nucleoplasm

45286:AW171 hschr42096
gene id: 45286:AW171_hschr42096
uniprot id: A0A0X8HRN3
names: Similarity
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Tetramer of two alpha and two beta subunits.

45286:AW171 hschr53051
gene id: 45286:AW171_hschr53051
uniprot id: A0A109UZI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
messages: Membrane
messages: Regulates also the sphingolipid metabolism.

45286:AW171 hschr2343
gene id: 45286:AW171_hschr2343
uniprot id: A0A109UWX2
names: Similarity
messages: Belongs to the COG4 family.

45286:AW171 hschr63488
gene id: 45286:AW171_hschr63488
uniprot id: A0A0X8HUA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: nucleolus

45286:AW171 hschr53316
gene id: 45286:AW171_hschr53316
uniprot id: A0A0X8HTV9
names: Subcellular Location Annotation
messages: Cell surface

45286:AW171 hschr53328
gene id: 45286:AW171_hschr53328
uniprot id: A0A109V056
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic GTase family.
messages: Heterodimer.
messages: Nucleus
messages: Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.

45286:AW171 hschr31929
gene id: 45286:AW171_hschr31929
uniprot id: A0A0X8HRD8
names: Cofactor
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Reduced FMN (FMNH(2)).

45286:AW171 hschr2124
gene id: 45286:AW171_hschr2124
uniprot id: A0A120K0S6
names: Function
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.

45286:AW171 hschr2118
gene id: 45286:AW171_hschr2118
uniprot id: A0A125RDU4
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

45286:AW171 hschr53027
gene id: 45286:AW171_hschr53027
uniprot id: A0A0X8HTD3
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

45286:AW171 hschr52982
gene id: 45286:AW171_hschr52982
uniprot id: A0A0X8HTA1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

45286:AW171 hschr63658
gene id: 45286:AW171_hschr63658
uniprot id: A0A0X8HUE8
names: Similarity
messages: Belongs to the IUNH family.

45286:AW171 hschr63719
gene id: 45286:AW171_hschr63719
uniprot id: A0A109UZY0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.

45286:AW171 hschr21045
gene id: 45286:AW171_hschr21045
uniprot id: A0A109UX98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

45286:AW171 hschr52866
gene id: 45286:AW171_hschr52866
uniprot id: A0A0X8HT13
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr74064
gene id: 45286:AW171_hschr74064
uniprot id: A0A0X8HV30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SOP4 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the export of PMA1, possibly through the monitoring or assisting of PMA1 folding and acquisition of competence to enter vesicles.
messages: Membrane

45286:AW171 hschr31880
gene id: 45286:AW171_hschr31880
uniprot id: A0A120K206
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

45286:AW171 hschr2909
gene id: 45286:AW171_hschr2909
uniprot id: A0A120K173
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr63632
gene id: 45286:AW171_hschr63632
uniprot id: A0A0X8HUI5
names: Similarity
messages: Belongs to the Cdt1 family.

45286:AW171 hschr31632
gene id: 45286:AW171_hschr31632
uniprot id: A0A109UYB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NifU family.
messages: Mitochondrion matrix
messages: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.

45286:AW171 hschr31602
gene id: 45286:AW171_hschr31602
uniprot id: A0A109UY95
names: Subcellular Location Annotation
messages: Cytoplasm

45286:AW171 hschr63848
gene id: 45286:AW171_hschr63848
uniprot id: A0A0X8HUQ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WRB/GET1 family.
messages: Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.

45286:AW171 hschr63616
gene id: 45286:AW171_hschr63616
uniprot id: A0A0X8HUA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Endosome membrane
messages: Membrane

45286:AW171 hschr74188
gene id: 45286:AW171_hschr74188
uniprot id: A0A0X8HVC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

45286:AW171 hschr63539
gene id: 45286:AW171_hschr63539
uniprot id: A0A0X8HU80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

45286:AW171 hschr42211
gene id: 45286:AW171_hschr42211
uniprot id: A0A0X8HRV5
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr31601
gene id: 45286:AW171_hschr31601
uniprot id: A0A109UWA8
names: Similarity
messages: Belongs to the PP2C family.

45286:AW171 hschr42148
gene id: 45286:AW171_hschr42148
uniprot id: A0A109UYX6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr85009
gene id: 45286:AW171_hschr85009
uniprot id: A0A120K2X6
names: Similarity
messages: Belongs to the NifU family.

45286:AW171 hschr21258
gene id: 45286:AW171_hschr21258
uniprot id: A0A109UXM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DTD family.
messages: Cytoplasm

45286:AW171 hschr2939
gene id: 45286:AW171_hschr2939
uniprot id: A0A120K191
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr53371
gene id: 45286:AW171_hschr53371
uniprot id: A0A109UZK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
messages: Cytoplasm
messages: nucleolus

45286:AW171 hschr63718
gene id: 45286:AW171_hschr63718
uniprot id: A0A0X8HUL1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

45286:AW171 hschr2429
gene id: 45286:AW171_hschr2429
uniprot id: A0A120K112
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

45286:AW171 hschr53399
gene id: 45286:AW171_hschr53399
uniprot id: A0A109UZJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INP1 family.
messages: Membrane
messages: Peroxisome membrane
messages: Required for peroxisome inheritance.

45286:AW171 hschr84842
gene id: 45286:AW171_hschr84842
uniprot id: A0A0X8HWF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus

45286:AW171 hschr84995
gene id: 45286:AW171_hschr84995
uniprot id: A0A0X8HWY4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

45286:AW171 hschr63940
gene id: 45286:AW171_hschr63940
uniprot id: A0A109UZV8
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

45286:AW171 hschr31766
gene id: 45286:AW171_hschr31766
uniprot id: A0A0X8HR46
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

45286:AW171 hschr63673
gene id: 45286:AW171_hschr63673
uniprot id: A0A109UZX0
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

45286:AW171 hschr63808
gene id: 45286:AW171_hschr63808
uniprot id: A0A0X8HUN1
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr74220
gene id: 45286:AW171_hschr74220
uniprot id: A0A0X8HUW6
names: Similarity
messages: Belongs to the 14-3-3 family.

45286:AW171 hschr63643
gene id: 45286:AW171_hschr63643
uniprot id: A0A120K2I9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL27 family.

45286:AW171 hschr74462
gene id: 45286:AW171_hschr74462
uniprot id: A0A109V052
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TPT transporter family. SLC35D subfamily.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homooligomer.
messages: Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.

45286:AW171 hschr2117
gene id: 45286:AW171_hschr2117
uniprot id: A0A109UW56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

45286:AW171 hschr74380
gene id: 45286:AW171_hschr74380
uniprot id: A0A0X8HVQ7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome.
messages: Nucleus
messages: Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends.

45286:AW171 hschr74330
gene id: 45286:AW171_hschr74330
uniprot id: A0A109V044
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Component of the GSE complex.
messages: GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.

45286:AW171 hschr2361
gene id: 45286:AW171_hschr2361
uniprot id: A0A120K0Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM RBM34 family.
messages: Involved in pre-25S rRNA processing.
messages: nucleolus

45286:AW171 hschr84975
gene id: 45286:AW171_hschr84975
uniprot id: A0A0X8HWP6
names: Similarity
messages: Belongs to the actin family.

45286:AW171 hschr2513
gene id: 45286:AW171_hschr2513
uniprot id: A0A109UXJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat peroxin-7 family.
messages: Peroxisome matrix
messages: cytosol

45286:AW171 hschr84809
gene id: 45286:AW171_hschr84809
uniprot id: A0A120K2V5
names: Similarity
messages: Belongs to the MAD2 family.

45286:AW171 hschr84596
gene id: 45286:AW171_hschr84596
uniprot id: A0A109UYE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Component of the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

45286:AW171 hschr42271
gene id: 45286:AW171_hschr42271
uniprot id: A0A0X8HS12
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr2232
gene id: 45286:AW171_hschr2232
uniprot id: A0A109UW80
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

45286:AW171 hschr84663
gene id: 45286:AW171_hschr84663
uniprot id: A0A0X8HWC1
names: Subcellular Location Annotation
messages: Nucleus membrane
messages: nuclear pore complex

45286:AW171 hschr42245
gene id: 45286:AW171_hschr42245
uniprot id: A0A109UWV3
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

45286:AW171 hschr63993
gene id: 45286:AW171_hschr63993
uniprot id: A0A0X8HV06
names: Similarity
messages: Belongs to the peptidase A1 family.

45286:AW171 hschr53114
gene id: 45286:AW171_hschr53114
uniprot id: A0A120K2D5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1A family.
messages: Nucleus
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

45286:AW171 hschr2945
gene id: 45286:AW171_hschr2945
uniprot id: A0A109UX77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAK10 family.
messages: Cytoplasm

45286:AW171 hschr84704
gene id: 45286:AW171_hschr84704
uniprot id: A0A109V0P9
names: Similarity
messages: Belongs to the MYST (SAS/MOZ) family.

45286:AW171 hschr74274
gene id: 45286:AW171_hschr74274
uniprot id: A0A0X8HVH6
names: Similarity
messages: Belongs to the HscB family.

45286:AW171 hschr2304
gene id: 45286:AW171_hschr2304
uniprot id: A0A109UX63
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr42794
gene id: 45286:AW171_hschr42794
uniprot id: A0A0X8HSW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin GLFG family.
messages: Nucleus membrane
messages: nuclear pore complex

45286:AW171 hschr42656
gene id: 45286:AW171_hschr42656
uniprot id: A0A120K283
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

45286:AW171 hschr74080
gene id: 45286:AW171_hschr74080
uniprot id: A0A0X8HVB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. PIF1 subfamily.
messages: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Involved in the maintenance of ribosomal (rDNA). Required for efficient fork arrest at the replicaion fork barrier within rDNA. Involved in the maintenance of mitochondrial (mtDNA). Required to maintain mtDNA under conditions that introduce dsDNA breaks in mtDNA, either preventing or repairing dsDNA breaks. May inhibit replication progression to allow time for repair. May have a general role in chromosomal replication by affecting Okazaki fragment maturation. May have a role in conjunction with DNA2 helicase/nuclease in 5'-flap extension during Okazaki fragment processing.
messages: Mitochondrion
messages: Monomer. Interacts with telomerase.
messages: Nucleus

45286:AW171 hschr84805
gene id: 45286:AW171_hschr84805
uniprot id: A0A0X8HWH5
names: Similarity
messages: Belongs to the NOP9 family.

45286:AW171 hschr84920
gene id: 45286:AW171_hschr84920
uniprot id: A0A109V0I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

45286:AW171 hschr84656
gene id: 45286:AW171_hschr84656
uniprot id: A0A109UYG4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Mitochondrion

45286:AW171 hschr21178
gene id: 45286:AW171_hschr21178
uniprot id: A0A120K1H5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

45286:AW171 hschr42490
gene id: 45286:AW171_hschr42490
uniprot id: A0A0X8HRE7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

45286:AW171 hschr2371
gene id: 45286:AW171_hschr2371
uniprot id: A0A109UWK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 15 family.
messages: Nucleus

45286:AW171 hschr52926
gene id: 45286:AW171_hschr52926
uniprot id: A0A0X8HSF2
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

45286:AW171 hschr2300
gene id: 45286:AW171_hschr2300
uniprot id: A0A109UWC7
names: Subcellular Location Annotation
messages: Mitochondrion

45286:AW171 hschr74436
gene id: 45286:AW171_hschr74436
uniprot id: A0A0X8HVY5
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

45286:AW171 hschr52896
gene id: 45286:AW171_hschr52896
uniprot id: A0A0X8HT38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HIR3 family.
messages: Nucleus

45286:AW171 hschr84732
gene id: 45286:AW171_hschr84732
uniprot id: A0A109V0F0
names: Cofactor
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.

45286:AW171 hschr53334
gene id: 45286:AW171_hschr53334
uniprot id: A0A0X8HTY0
names: Subcellular Location Annotation
messages: nucleolus

45286:AW171 hschr74248
gene id: 45286:AW171_hschr74248
uniprot id: A0A0X8HVK3
names: Similarity
messages: Belongs to the peptidase C19 family.

45286:AW171 hschr53140
gene id: 45286:AW171_hschr53140
uniprot id: A0A0X8HTI5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

45286:AW171 hschr63950
gene id: 45286:AW171_hschr63950
uniprot id: A0A0X8HUW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: Membrane

45286:AW171 hschr74251
gene id: 45286:AW171_hschr74251
uniprot id: A0A0X8HVH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

45286:AW171 hschr21155
gene id: 45286:AW171_hschr21155
uniprot id: A0A109UXL6
names: Similarity
messages: Belongs to the actin family.

45286:AW171 hschr2360
gene id: 45286:AW171_hschr2360
uniprot id: A0A109UWH5
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr84677
gene id: 45286:AW171_hschr84677
uniprot id: A0A0X8HW60
names: Similarity
messages: Belongs to the heat shock protein 70 family.

45286:AW171 hschr53420
gene id: 45286:AW171_hschr53420
uniprot id: A0A0X8HU30
names: Similarity
messages: Belongs to the threonine synthase family.

45286:AW171 hschr63521
gene id: 45286:AW171_hschr63521
uniprot id: A0A0X8HUB9
names: Similarity
messages: Belongs to the MOG1 family.

45286:AW171 hschr31346
gene id: 45286:AW171_hschr31346
uniprot id: A0A109UXY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF3 subfamily.
messages: Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.

45286:AW171 hschr2305
gene id: 45286:AW171_hschr2305
uniprot id: A0A109UWI5
names: Similarity
messages: Belongs to the PP2C family.

45286:AW171 hschr85062
gene id: 45286:AW171_hschr85062
uniprot id: A0A0X8HWY2
names: Similarity
messages: Belongs to the TMEM14 family.

45286:AW171 hschr2882
gene id: 45286:AW171_hschr2882
uniprot id: A0A109UXR1
names: Similarity
messages: Belongs to the RENT3 family.

45286:AW171 hschr53332
gene id: 45286:AW171_hschr53332
uniprot id: A0A0X8HTT5
names: Similarity
messages: Belongs to the CBP3 family.

45286:AW171 hschr85083
gene id: 45286:AW171_hschr85083
uniprot id: A0A109UYR0
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

45286:AW171 hschr74472
gene id: 45286:AW171_hschr74472
uniprot id: A0A0X8HVV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

45286:AW171 hschr31884
gene id: 45286:AW171_hschr31884
uniprot id: A0A0X8HRC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus

45286:AW171 hschr53029
gene id: 45286:AW171_hschr53029
uniprot id: A0A0X8HTC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

45286:AW171 hschr233
gene id: 45286:AW171_hschr233
uniprot id: A0A109UVY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

45286:AW171 hschr31297
gene id: 45286:AW171_hschr31297
uniprot id: A0A109UVS5
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr74459
gene id: 45286:AW171_hschr74459
uniprot id: A0A0X8HVV3
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr42118
gene id: 45286:AW171_hschr42118
uniprot id: A0A109UYQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRG7 family.
messages: Mitochondrion

45286:AW171 hschr2911
gene id: 45286:AW171_hschr2911
uniprot id: A0A125RE09
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

45286:AW171 hschr2515
gene id: 45286:AW171_hschr2515
uniprot id: A0A109UWU9
names: Similarity
messages: Belongs to the peptidase A1 family.

45286:AW171 hschr2493
gene id: 45286:AW171_hschr2493
uniprot id: A0A109UWQ3
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

45286:AW171 hschr63866
gene id: 45286:AW171_hschr63866
uniprot id: A0A0X8HUX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

45286:AW171 hschr63713
gene id: 45286:AW171_hschr63713
uniprot id: A0A0X8HUF6
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

45286:AW171 hschr63583
gene id: 45286:AW171_hschr63583
uniprot id: A0A0X8HUE9
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

45286:AW171 hschr2536
gene id: 45286:AW171_hschr2536
uniprot id: A0A120K150
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: cytosol

45286:AW171 hschr31582
gene id: 45286:AW171_hschr31582
uniprot id: A0A109UYZ7
names: Similarity
messages: Belongs to the Tom22 family.

45286:AW171 hschr31592
gene id: 45286:AW171_hschr31592
uniprot id: A0A120K1V6
names: Similarity
messages: Belongs to the NOP10 family.

45286:AW171 hschr31814
gene id: 45286:AW171_hschr31814
uniprot id: A0A0X8HR72
names: Function
names: Similarity
messages: 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

45286:AW171 hschr53409
gene id: 45286:AW171_hschr53409
uniprot id: A0A0X8HU52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr74280
gene id: 45286:AW171_hschr74280
uniprot id: A0A0X8HVI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLA1 family.
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

45286:AW171 hschr74400
gene id: 45286:AW171_hschr74400
uniprot id: A0A109V067
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC2 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Component of the origin recognition complex (ORC).
messages: Nucleus

45286:AW171 hschr31443
gene id: 45286:AW171_hschr31443
uniprot id: A0A109UXZ8
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

45286:AW171 hschr31464
gene id: 45286:AW171_hschr31464
uniprot id: A0A109UY06
names: Similarity
messages: Belongs to the peptidase C14B family.

45286:AW171 hschr2293
gene id: 45286:AW171_hschr2293
uniprot id: A0A109UWC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm

45286:AW171 hschr42543
gene id: 45286:AW171_hschr42543
uniprot id: A0A120K273
names: Similarity
messages: Belongs to the protein kinase superfamily.

45286:AW171 hschr42582
gene id: 45286:AW171_hschr42582
uniprot id: A0A0X8HSL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dUTPase family.
messages: Homotrimer.
messages: Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

45286:AW171 hschr21079
gene id: 45286:AW171_hschr21079
uniprot id: A0A120K1E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr42565
gene id: 45286:AW171_hschr42565
uniprot id: A0A0X8HSF5
names: Similarity
messages: Belongs to the UQCRH/QCR6 family.

45286:AW171 hschr42436
gene id: 45286:AW171_hschr42436
uniprot id: A0A0X8HSA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr32035
gene id: 45286:AW171_hschr32035
uniprot id: A0A109UYK3
names: Similarity
messages: Belongs to the NPR2 family.

45286:AW171 hschr31862
gene id: 45286:AW171_hschr31862
uniprot id: A0A0X8HRA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.

45286:AW171 hschr74146
gene id: 45286:AW171_hschr74146
uniprot id: A0A0X8HVF0
names: Similarity
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.
messages: Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

45286:AW171 hschr42409
gene id: 45286:AW171_hschr42409
uniprot id: A0A0X8HR88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Vacuole membrane

45286:AW171 hschr42507
gene id: 45286:AW171_hschr42507
uniprot id: A0A0X8HSE4
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.

45286:AW171 hschr63682
gene id: 45286:AW171_hschr63682
uniprot id: A0A0X8HUD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INP2 family.
messages: Membrane
messages: Peroxisome membrane

45286:AW171 hschr2873
gene id: 45286:AW171_hschr2873
uniprot id: A0A109UWY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NUF2 family.
messages: kinetochore

45286:AW171 hschr85052
gene id: 45286:AW171_hschr85052
uniprot id: A0A120K2Y3
names: Similarity
messages: Belongs to the UPF0538 family.

45286:AW171 hschr74121
gene id: 45286:AW171_hschr74121
uniprot id: A0A0X8HV65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

45286:AW171 hschr53155
gene id: 45286:AW171_hschr53155
uniprot id: A0A0X8HTJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SNW family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

45286:AW171 hschr53182
gene id: 45286:AW171_hschr53182
uniprot id: A0A0X8HTI7
names: Similarity
messages: Belongs to the protein kinase superfamily.

45286:AW171 hschr74471
gene id: 45286:AW171_hschr74471
uniprot id: A0A0X8HVZ1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MDM34 family.
messages: Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.
messages: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.
messages: Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.
messages: Mitochondrion outer membrane

45286:AW171 hschr2959
gene id: 45286:AW171_hschr2959
uniprot id: A0A125RE15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: cis-Golgi network

45286:AW171 hschr2370
gene id: 45286:AW171_hschr2370
uniprot id: A0A109UWM6
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

45286:AW171 hschr52922
gene id: 45286:AW171_hschr52922
uniprot id: A0A0X8HT21
names: Similarity
messages: Belongs to the HMBS family.

45286:AW171 hschr31571
gene id: 45286:AW171_hschr31571
uniprot id: A0A109UY62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC6 family.
messages: Nucleus

45286:AW171 hschr42418
gene id: 45286:AW171_hschr42418
uniprot id: A0A109UZL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NFX1 family.
messages: Nucleus

45286:AW171 hschr42189
gene id: 45286:AW171_hschr42189
uniprot id: A0A0X8HRY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
messages: Mitochondrion membrane

45286:AW171 hschr42696
gene id: 45286:AW171_hschr42696
uniprot id: A0A0X8HST4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.
messages: Endoplasmic reticulum membrane

45286:AW171 hschr42529
gene id: 45286:AW171_hschr42529
uniprot id: A0A109UZD6
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

45286:AW171 hschr84542
gene id: 45286:AW171_hschr84542
uniprot id: A0A0X8HVI5
names: Similarity
messages: Belongs to the DEAD box helicase family.

45286:AW171 hschr74054
gene id: 45286:AW171_hschr74054
uniprot id: A0A0X8HUL7
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

45286:AW171 hschr42208
gene id: 45286:AW171_hschr42208
uniprot id: A0A0X8HQV9
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

45286:AW171 hschr31460
gene id: 45286:AW171_hschr31460
uniprot id: A0A120K1Q1
names: Similarity
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.

45286:AW171 hschr2212
gene id: 45286:AW171_hschr2212
uniprot id: A0A109UWA9
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate 1-epimerase family.
messages: Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).

45286:AW171 hschr85096
gene id: 45286:AW171_hschr85096
uniprot id: A0A0X8HWX1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

45286:AW171 hschr42597
gene id: 45286:AW171_hschr42597
uniprot id: A0A0X8HSH4
names: Similarity
messages: Belongs to the TEL2 family.

45286:AW171 hschr21013
gene id: 45286:AW171_hschr21013
uniprot id: A0A109UXM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 20 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Nucleus

45286:AW171 hschr42251
gene id: 45286:AW171_hschr42251
uniprot id: A0A0X8HRW6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

45286:AW171 hschr74137
gene id: 45286:AW171_hschr74137
uniprot id: A0A0X8HV74
names: Function
names: Similarity
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.

45286:AW171 hschr42465
gene id: 45286:AW171_hschr42465
uniprot id: A0A0X8HSE2
names: Function
names: Similarity
messages: Belongs to the Rab GDI family.
messages: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

45286:AW171 hschr25
gene id: 45286:AW171_hschr25
uniprot id: A0A109UWM0
names: Similarity
messages: Belongs to the FBPase class 1 family.

45286:AW171 hschr63916
gene id: 45286:AW171_hschr63916
uniprot id: A0A0X8HV22
names: Similarity
messages: Belongs to the protein kinase superfamily.

45286:AW171 hschr84967
gene id: 45286:AW171_hschr84967
uniprot id: A0A0X8HWP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

45286:AW171 hschr74351
gene id: 45286:AW171_hschr74351
uniprot id: A0A109V0R5
names: Similarity
messages: Belongs to the NEMF family.

45286:AW171 hschr42171
gene id: 45286:AW171_hschr42171
uniprot id: A0A0X8HRU8
names: Similarity
messages: Belongs to the peptidase A1 family.

45286:AW171 hschr63765
gene id: 45286:AW171_hschr63765
uniprot id: A0A0X8HTZ1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.
messages: Mitochondrion matrix

45286:AW171 hschr74199
gene id: 45286:AW171_hschr74199
uniprot id: A0A0X8HVA9
names: Similarity
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.

45286:AW171 hschr53440
gene id: 45286:AW171_hschr53440
uniprot id: A0A0X8HU72
names: Similarity
messages: In the C-terminal section; belongs to the TrpB family.
messages: In the N-terminal section; belongs to the TrpA family.

45286:AW171 hschr74019
gene id: 45286:AW171_hschr74019
uniprot id: A0A0X8HV23
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr84639
gene id: 45286:AW171_hschr84639
uniprot id: A0A120K2U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
messages: nucleolus

45286:AW171 hschr21189
gene id: 45286:AW171_hschr21189
uniprot id: A0A109UXI5
names: Similarity
messages: Belongs to the phospholipase D family.

45286:AW171 hschr84788
gene id: 45286:AW171_hschr84788
uniprot id: A0A0X8HVZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.

45286:AW171 hschr85049
gene id: 45286:AW171_hschr85049
uniprot id: A0A109V0J9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.

45286:AW171 hschr21072
gene id: 45286:AW171_hschr21072
uniprot id: A0A109UXD6
names: Similarity
messages: Belongs to the peptidase A1 family.

45286:AW171 hschr42122
gene id: 45286:AW171_hschr42122
uniprot id: A0A120K229
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

45286:AW171 hschr2908
gene id: 45286:AW171_hschr2908
uniprot id: A0A109UWZ6
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

45286:AW171 hschr31983
gene id: 45286:AW171_hschr31983
uniprot id: A0A0X8HRI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND1 (condensin subunit 1) family.
messages: Chromosome
messages: Nucleus
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

45286:AW171 hschr2530
gene id: 45286:AW171_hschr2530
uniprot id: A0A109UWW0
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

45286:AW171 hschr52921
gene id: 45286:AW171_hschr52921
uniprot id: A0A0X8HT56
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.
messages: Mitochondrion

45286:AW171 hschr31832
gene id: 45286:AW171_hschr31832
uniprot id: A0A120K201
names: Function
names: Similarity
messages: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the proteasome subunit S1 family.

45286:AW171 hschr74075
gene id: 45286:AW171_hschr74075
uniprot id: A0A109UZW4
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

45286:AW171 hschr31406
gene id: 45286:AW171_hschr31406
uniprot id: A0A109UYN3
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr63602
gene id: 45286:AW171_hschr63602
uniprot id: A0A0X8HUG4
names: Similarity
messages: Belongs to the TAF11 family.

45286:AW171 hschr2846
gene id: 45286:AW171_hschr2846
uniprot id: A0A120K159
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

45286:AW171 hschr63910
gene id: 45286:AW171_hschr63910
uniprot id: A0A120K2L6
names: Similarity
messages: Belongs to the citrate synthase family.

45286:AW171 hschr74102
gene id: 45286:AW171_hschr74102
uniprot id: A0A0X8HV87
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

45286:AW171 hschr31437
gene id: 45286:AW171_hschr31437
uniprot id: A0A109UYQ4
names: Cofactor
names: Similarity
messages: Belongs to the glutamate synthase family.
messages: Binds 1 [3Fe-4S] cluster.

45286:AW171 hschr31962
gene id: 45286:AW171_hschr31962
uniprot id: A0A0X8HRG1
names: Similarity
messages: Belongs to the cullin family.

45286:AW171 hschr31696
gene id: 45286:AW171_hschr31696
uniprot id: A0A109UYF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYF2 family.
messages: Involved in pre-mRNA splicing.
messages: May be part of a spliceosome complex.
messages: Nucleus

45286:AW171 hschr42778
gene id: 45286:AW171_hschr42778
uniprot id: A0A0X8HSV8
names: Similarity
messages: Belongs to the actin family.

45286:AW171 hschr74058
gene id: 45286:AW171_hschr74058
uniprot id: A0A120K2N0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ9 family.
messages: Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
messages: Mitochondrion

45286:AW171 hschr53038
gene id: 45286:AW171_hschr53038
uniprot id: A0A120K2C3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Endoplasmic reticulum membrane
messages: Functions as a zinc transporter.
messages: Membrane

45286:AW171 hschr2423
gene id: 45286:AW171_hschr2423
uniprot id: A0A120K114
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Binds 2 magnesium ions. Also active with manganese.
messages: Nucleus
messages: Polymerase that creates the 3'-poly(A) tail of mRNA's.

45286:AW171 hschr84861
gene id: 45286:AW171_hschr84861
uniprot id: A0A120K2W4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the squalene monooxygenase family.
messages: Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

45286:AW171 hschr42292
gene id: 45286:AW171_hschr42292
uniprot id: A0A109UYU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycogen debranching enzyme family.
messages: Cytoplasm
messages: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.

45286:AW171 hschr31956
gene id: 45286:AW171_hschr31956
uniprot id: A0A109UWP0
names: Similarity
messages: Belongs to the PPP phosphatase family.

45286:AW171 hschr2879
gene id: 45286:AW171_hschr2879
uniprot id: A0A120K165
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NPC2 family.
messages: Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
messages: Monomer.

45286:AW171 hschr42294
gene id: 45286:AW171_hschr42294
uniprot id: A0A109UYV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

45286:AW171 hschr74242
gene id: 45286:AW171_hschr74242
uniprot id: A0A120K2P8
names: Similarity
messages: Belongs to the SCC4/mau-2 family.

45286:AW171 hschr53112
gene id: 45286:AW171_hschr53112
uniprot id: A0A109UZC9
names: Similarity
messages: Belongs to the enolase family.

45286:AW171 hschr84917
gene id: 45286:AW171_hschr84917
uniprot id: A0A109V0E4
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

45286:AW171 hschr42774
gene id: 45286:AW171_hschr42774
uniprot id: A0A0X8HSW7
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr74296
gene id: 45286:AW171_hschr74296
uniprot id: A0A0X8HVJ7
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr42080
gene id: 45286:AW171_hschr42080
uniprot id: A0A0X8HRM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Mitochondrion

45286:AW171 hschr42385
gene id: 45286:AW171_hschr42385
uniprot id: A0A109UYX5
names: Function
names: Similarity
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome.

45286:AW171 hschr63749
gene id: 45286:AW171_hschr63749
uniprot id: A0A0X8HUN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PurH family.
messages: cytosol

45286:AW171 hschr2974
gene id: 45286:AW171_hschr2974
uniprot id: A0A109UX75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

45286:AW171 hschr63527
gene id: 45286:AW171_hschr63527
uniprot id: A0A109UZT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC3 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).

45286:AW171 hschr63733
gene id: 45286:AW171_hschr63733
uniprot id: A0A0X8HUM1
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

45286:AW171 hschr53279
gene id: 45286:AW171_hschr53279
uniprot id: A0A109V047
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export.
messages: Cytoplasm
messages: Nucleus

45286:AW171 hschr31851
gene id: 45286:AW171_hschr31851
uniprot id: A0A0X8HR90
names: Similarity
names: Subcellular Location Annotation
messages: In the C-terminal section; belongs to the NAGSA dehydrogenase family.
messages: In the N-terminal section; belongs to the acetylglutamate kinase family.
messages: Mitochondrion

45286:AW171 hschr31830
gene id: 45286:AW171_hschr31830
uniprot id: A0A120K1Z8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr2856
gene id: 45286:AW171_hschr2856
uniprot id: A0A109UXC9
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

45286:AW171 hschr74338
gene id: 45286:AW171_hschr74338
uniprot id: A0A0X8HVK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.
messages: Cytoplasm
messages: Nucleus

45286:AW171 hschr31598
gene id: 45286:AW171_hschr31598
uniprot id: A0A109UZ08
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

45286:AW171 hschr2357
gene id: 45286:AW171_hschr2357
uniprot id: A0A125RDX4
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

45286:AW171 hschr42200
gene id: 45286:AW171_hschr42200
uniprot id: A0A109UZ66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDA1 family.
messages: Required for 60S pre-ribosomal subunits export to the cytoplasm.
messages: nucleolus

45286:AW171 hschr2160
gene id: 45286:AW171_hschr2160
uniprot id: A0A109UW66
names: Similarity
messages: Belongs to the exportin family.

45286:AW171 hschr74076
gene id: 45286:AW171_hschr74076
uniprot id: A0A109UXZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Endoplasmic reticulum membrane
messages: Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis.

45286:AW171 hschr84777
gene id: 45286:AW171_hschr84777
uniprot id: A0A120K2V8
names: Similarity
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.

45286:AW171 hschr84539
gene id: 45286:AW171_hschr84539
uniprot id: A0A0X8HW38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Nucleus

45286:AW171 hschr42516
gene id: 45286:AW171_hschr42516
uniprot id: A0A0X8HSF8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

45286:AW171 hschr84867
gene id: 45286:AW171_hschr84867
uniprot id: A0A0X8HWP4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

45286:AW171 hschr21147
gene id: 45286:AW171_hschr21147
uniprot id: A0A120K1F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC3 subfamily.
messages: Nucleus

45286:AW171 hschr42380
gene id: 45286:AW171_hschr42380
uniprot id: A0A0X8HS64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

45286:AW171 hschr84742
gene id: 45286:AW171_hschr84742
uniprot id: A0A0X8HVW1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

45286:AW171 hschr42732
gene id: 45286:AW171_hschr42732
uniprot id: A0A0X8HSS8
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

45286:AW171 hschr53184
gene id: 45286:AW171_hschr53184
uniprot id: A0A0X8HTP1
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

45286:AW171 hschr2179
gene id: 45286:AW171_hschr2179
uniprot id: A0A109UWY0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
messages: Cytoplasm

45286:AW171 hschr31626
gene id: 45286:AW171_hschr31626
uniprot id: A0A109UYD3
names: Similarity
messages: Belongs to the exportin family.

45286:AW171 hschr63532
gene id: 45286:AW171_hschr63532
uniprot id: A0A109UZZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.

45286:AW171 hschr2406
gene id: 45286:AW171_hschr2406
uniprot id: A0A109UWK7
names: Similarity
messages: Belongs to the MUB1/samB family.

45286:AW171 hschr52920
gene id: 45286:AW171_hschr52920
uniprot id: A0A0X8HT76
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr292
gene id: 45286:AW171_hschr292
uniprot id: A0A120K0Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

45286:AW171 hschr53115
gene id: 45286:AW171_hschr53115
uniprot id: A0A120K2D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: Nucleus

45286:AW171 hschr85047
gene id: 45286:AW171_hschr85047
uniprot id: A0A0X8HWG3
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr275
gene id: 45286:AW171_hschr275
uniprot id: A0A120K0P7
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.

45286:AW171 hschr74232
gene id: 45286:AW171_hschr74232
uniprot id: A0A0X8HVJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

45286:AW171 hschr42646
gene id: 45286:AW171_hschr42646
uniprot id: A0A0X8HSQ5
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

45286:AW171 hschr31476
gene id: 45286:AW171_hschr31476
uniprot id: A0A120K1Q3
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

45286:AW171 hschr74423
gene id: 45286:AW171_hschr74423
uniprot id: A0A0X8HVW6
names: Similarity
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Homodimer.

45286:AW171 hschr53249
gene id: 45286:AW171_hschr53249
uniprot id: A0A0X8HTU2
names: Similarity
messages: Belongs to the ERT1/acuK family.

45286:AW171 hschr53268
gene id: 45286:AW171_hschr53268
uniprot id: A0A0X8HTV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM NCBP2 family.
messages: Nucleus

45286:AW171 hschr21197
gene id: 45286:AW171_hschr21197
uniprot id: A0A120K1G4
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

45286:AW171 hschr74314
gene id: 45286:AW171_hschr74314
uniprot id: A0A109V0B1
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

45286:AW171 hschr84760
gene id: 45286:AW171_hschr84760
uniprot id: A0A109V0E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL40 family.
messages: Mitochondrion

45286:AW171 hschr74491
gene id: 45286:AW171_hschr74491
uniprot id: A0A109V049
names: Similarity
messages: Belongs to the proteasome subunit S14 family.

45286:AW171 hschr2148
gene id: 45286:AW171_hschr2148
uniprot id: A0A109UW74
names: Similarity
messages: Belongs to the KNR4/SMI1 family.

45286:AW171 hschr84690
gene id: 45286:AW171_hschr84690
uniprot id: A0A0X8HW79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Nucleus
messages: Required both for recombination and for the repair of DNA damage caused by X-rays.

45286:AW171 hschr84745
gene id: 45286:AW171_hschr84745
uniprot id: A0A0X8HW96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC12 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER.

45286:AW171 hschr84548
gene id: 45286:AW171_hschr84548
uniprot id: A0A109UYC1
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

45286:AW171 hschr53309
gene id: 45286:AW171_hschr53309
uniprot id: A0A0X8HTT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

45286:AW171 hschr84523
gene id: 45286:AW171_hschr84523
uniprot id: A0A0X8HVH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PAM17 family.
messages: Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Component of the PAM complex.
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr85059
gene id: 45286:AW171_hschr85059
uniprot id: A0A0X8HWU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

45286:AW171 hschr31764
gene id: 45286:AW171_hschr31764
uniprot id: A0A0X8HR42
names: Similarity
messages: Belongs to the DOCK family.

45286:AW171 hschr84590
gene id: 45286:AW171_hschr84590
uniprot id: A0A0X8HVL4
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.

45286:AW171 hschr74366
gene id: 45286:AW171_hschr74366
uniprot id: A0A109V0G9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNF8 family.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).

45286:AW171 hschr84646
gene id: 45286:AW171_hschr84646
uniprot id: A0A0X8HW40
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit.
messages: Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
messages: nucleolus

45286:AW171 hschr63968
gene id: 45286:AW171_hschr63968
uniprot id: A0A0X8HV36
names: Similarity
messages: Belongs to the ELP6 family.

45286:AW171 hschr31491
gene id: 45286:AW171_hschr31491
uniprot id: A0A120K1Q8
names: Function
names: Similarity
messages: Belongs to the PanB family.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.

45286:AW171 hschr31415
gene id: 45286:AW171_hschr31415
uniprot id: A0A120K1Q0
names: Similarity
messages: Belongs to the SMC family. RAD50 subfamily.

45286:AW171 hschr31752
gene id: 45286:AW171_hschr31752
uniprot id: A0A120K1Y7
names: Similarity
messages: Belongs to the WD repeat coronin family.

45286:AW171 hschr31485
gene id: 45286:AW171_hschr31485
uniprot id: A0A109UY51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPL4 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway.
messages: Membrane
messages: Nucleus membrane
messages: perinuclear region

45286:AW171 hschr31944
gene id: 45286:AW171_hschr31944
uniprot id: A0A0X8HRE8
names: Similarity
messages: Belongs to the biotin--protein ligase family.

45286:AW171 hschr31420
gene id: 45286:AW171_hschr31420
uniprot id: A0A109UVZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RTC4 family.
messages: May be involved in a process influencing telomere capping.
messages: Nucleus

45286:AW171 hschr42567
gene id: 45286:AW171_hschr42567
uniprot id: A0A0X8HSK4
names: Function
names: Similarity
messages: Belongs to the RRT5 family.
messages: May be involved in the modulation of rDNA transcription.

45286:AW171 hschr42541
gene id: 45286:AW171_hschr42541
uniprot id: A0A0X8HSF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr74159
gene id: 45286:AW171_hschr74159
uniprot id: A0A109UY12
names: Similarity
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

45286:AW171 hschr21060
gene id: 45286:AW171_hschr21060
uniprot id: A0A109UXA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP4 family.
messages: Cytoplasm

45286:AW171 hschr84657
gene id: 45286:AW171_hschr84657
uniprot id: A0A109V0C9
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.

45286:AW171 hschr31671
gene id: 45286:AW171_hschr31671
uniprot id: A0A109UYA7
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
messages: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

45286:AW171 hschr42450
gene id: 45286:AW171_hschr42450
uniprot id: A0A0X8HSD1
names: Similarity
messages: Belongs to the BolA/IbaG family.

45286:AW171 hschr53393
gene id: 45286:AW171_hschr53393
uniprot id: A0A0X8HTW9
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr63703
gene id: 45286:AW171_hschr63703
uniprot id: A0A0X8HUK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NUR1 family.
messages: Member of a perinuclear network that controls recombination at multiple loci to maintain genome stability. Required for rDNA repeat stability.
messages: Membrane
messages: Nucleus membrane

45286:AW171 hschr84877
gene id: 45286:AW171_hschr84877
uniprot id: A0A109V129
names: Function
names: Subcellular Location Annotation
messages: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Nucleus

45286:AW171 hschr53226
gene id: 45286:AW171_hschr53226
uniprot id: A0A0X8HTN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Membrane

45286:AW171 hschr84936
gene id: 45286:AW171_hschr84936
uniprot id: A0A109UYN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: cytosol

45286:AW171 hschr42127
gene id: 45286:AW171_hschr42127
uniprot id: A0A0X8HRP4
names: Similarity
messages: Belongs to the glycosyl hydrolase 76 family.

45286:AW171 hschr2404
gene id: 45286:AW171_hschr2404
uniprot id: A0A109UWJ2
names: Similarity
messages: Belongs to the UPP synthase family.

45286:AW171 hschr84797
gene id: 45286:AW171_hschr84797
uniprot id: A0A0X8HWE9
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

45286:AW171 hschr63984
gene id: 45286:AW171_hschr63984
uniprot id: A0A0X8HV05
names: Similarity
messages: Belongs to the CWC22 family.

45286:AW171 hschr21126
gene id: 45286:AW171_hschr21126
uniprot id: A0A109UXF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat UTP18 family.
messages: nucleolus

45286:AW171 hschr53064
gene id: 45286:AW171_hschr53064
uniprot id: A0A0X8HSP0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

45286:AW171 hschr42850
gene id: 45286:AW171_hschr42850
uniprot id: A0A109UZW1
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

45286:AW171 hschr21064
gene id: 45286:AW171_hschr21064
uniprot id: A0A120K1D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

45286:AW171 hschr42199
gene id: 45286:AW171_hschr42199
uniprot id: A0A109UYT3
names: Similarity
messages: Belongs to the TFIIB family.

45286:AW171 hschr53434
gene id: 45286:AW171_hschr53434
uniprot id: A0A109UZK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPC1 family.
messages: Membrane

45286:AW171 hschr2985
gene id: 45286:AW171_hschr2985
uniprot id: A0A120K1B2
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

45286:AW171 hschr52952
gene id: 45286:AW171_hschr52952
uniprot id: A0A0X8HT83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR1 family.
messages: Component of several multiprotein Golgi SNARE complexes.
messages: Golgi apparatus membrane
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.
messages: Membrane

45286:AW171 hschr21191
gene id: 45286:AW171_hschr21191
uniprot id: A0A109UXJ0
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr2129
gene id: 45286:AW171_hschr2129
uniprot id: A0A109UW43
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

45286:AW171 hschr53037
gene id: 45286:AW171_hschr53037
uniprot id: A0A0X8HTB6
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

45286:AW171 hschr63569
gene id: 45286:AW171_hschr63569
uniprot id: A0A0X8HUB6
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

45286:AW171 hschr31456
gene id: 45286:AW171_hschr31456
uniprot id: A0A109UXZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
messages: Nucleus

45286:AW171 hschr2250
gene id: 45286:AW171_hschr2250
uniprot id: A0A120K0V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Mitochondrion matrix

45286:AW171 hschr31639
gene id: 45286:AW171_hschr31639
uniprot id: A0A120K1W2
names: Function
names: Subcellular Location Annotation
messages: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
messages: Mitochondrion inner membrane

45286:AW171 hschr63473
gene id: 45286:AW171_hschr63473
uniprot id: A0A0X8HU92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: Cytoplasm

45286:AW171 hschr268
gene id: 45286:AW171_hschr268
uniprot id: A0A109UWR1
names: Similarity
messages: Belongs to the peptidase C19 family.

45286:AW171 hschr2358
gene id: 45286:AW171_hschr2358
uniprot id: A0A109UWG1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.

45286:AW171 hschr29
gene id: 45286:AW171_hschr29
uniprot id: A0A109UVT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRE9/KNH1 family.
messages: Involved in cell wall beta(1->6) glucan synthesis.
messages: cell wall

45286:AW171 hschr2979
gene id: 45286:AW171_hschr2979
uniprot id: A0A125RE18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BIG1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr53319
gene id: 45286:AW171_hschr53319
uniprot id: A0A0X8HTW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Endoplasmic reticulum membrane
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.

45286:AW171 hschr2292
gene id: 45286:AW171_hschr2292
uniprot id: A0A125RDW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT2/3/5 family.
messages: Nucleus

45286:AW171 hschr52883
gene id: 45286:AW171_hschr52883
uniprot id: A0A0X8HT24
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr53074
gene id: 45286:AW171_hschr53074
uniprot id: A0A0X8HTF7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

45286:AW171 hschr42136
gene id: 45286:AW171_hschr42136
uniprot id: A0A109UYT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.
messages: Nucleus

45286:AW171 hschr21019
gene id: 45286:AW171_hschr21019
uniprot id: A0A109UX71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

45286:AW171 hschr2333
gene id: 45286:AW171_hschr2333
uniprot id: A0A120K0Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane

45286:AW171 hschr42081
gene id: 45286:AW171_hschr42081
uniprot id: A0A0X8HRP9
names: Similarity
messages: Belongs to the FYV7 family.

45286:AW171 hschr31447
gene id: 45286:AW171_hschr31447
uniprot id: A0A120K1P9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

45286:AW171 hschr42324
gene id: 45286:AW171_hschr42324
uniprot id: A0A109UYX8
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

45286:AW171 hschr63538
gene id: 45286:AW171_hschr63538
uniprot id: A0A0X8HUD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

45286:AW171 hschr63860
gene id: 45286:AW171_hschr63860
uniprot id: A0A109V0G6
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

45286:AW171 hschr63941
gene id: 45286:AW171_hschr63941
uniprot id: A0A0X8HUV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

45286:AW171 hschr74273
gene id: 45286:AW171_hschr74273
uniprot id: A0A109V0E9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Regulatory subunit of casein kinase II/CK2 (By similarity). As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
messages: Tetramer of two alpha and two beta subunits.

45286:AW171 hschr84787
gene id: 45286:AW171_hschr84787
uniprot id: A0A0X8HWG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP receptor beta subunit family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr2302
gene id: 45286:AW171_hschr2302
uniprot id: A0A109UWG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.
messages: Nucleus

45286:AW171 hschr63939
gene id: 45286:AW171_hschr63939
uniprot id: A0A0X8HUZ1
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane

45286:AW171 hschr2264
gene id: 45286:AW171_hschr2264
uniprot id: A0A109UWB4
names: Similarity
messages: Belongs to the FES1 family.

45286:AW171 hschr2437
gene id: 45286:AW171_hschr2437
uniprot id: A0A125RDY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingosine N-acyltransferase family.
messages: Membrane

45286:AW171 hschr84862
gene id: 45286:AW171_hschr84862
uniprot id: A0A120K2W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRN7/TAF1B family.
messages: nucleolus

45286:AW171 hschr2949
gene id: 45286:AW171_hschr2949
uniprot id: A0A109UX22
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr31555
gene id: 45286:AW171_hschr31555
uniprot id: A0A109UW81
names: Similarity
messages: Belongs to the DEAD box helicase family.

45286:AW171 hschr31741
gene id: 45286:AW171_hschr31741
uniprot id: A0A0X8HR23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane

45286:AW171 hschr63699
gene id: 45286:AW171_hschr63699
uniprot id: A0A0X8HUN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP14 family.
messages: Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
messages: Cytoplasm

45286:AW171 hschr74035
gene id: 45286:AW171_hschr74035
uniprot id: A0A0X8HV04
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr31393
gene id: 45286:AW171_hschr31393
uniprot id: A0A109UVY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: DNA polymerase II participates in chromosomal DNA replication.
messages: Nucleus

45286:AW171 hschr2176
gene id: 45286:AW171_hschr2176
uniprot id: A0A120K0T2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF beta-subunit/FixA family.
messages: Binds 1 AMP per subunit.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

45286:AW171 hschr53217
gene id: 45286:AW171_hschr53217
uniprot id: A0A0X8HTQ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

45286:AW171 hschr31490
gene id: 45286:AW171_hschr31490
uniprot id: A0A120K1R1
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.

45286:AW171 hschr31831
gene id: 45286:AW171_hschr31831
uniprot id: A0A120K200
names: Subcellular Location Annotation
messages: nucleolus

45286:AW171 hschr31600
gene id: 45286:AW171_hschr31600
uniprot id: A0A109UYA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase e subunit family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

45286:AW171 hschr74378
gene id: 45286:AW171_hschr74378
uniprot id: A0A0X8HV76
names: Similarity
messages: Belongs to the peptidase M24B family.

45286:AW171 hschr2354
gene id: 45286:AW171_hschr2354
uniprot id: A0A109UX96
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).

45286:AW171 hschr63515
gene id: 45286:AW171_hschr63515
uniprot id: A0A109V097
names: Subcellular Location Annotation
messages: Cytoplasm

45286:AW171 hschr63928
gene id: 45286:AW171_hschr63928
uniprot id: A0A109UXV8
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr2455
gene id: 45286:AW171_hschr2455
uniprot id: A0A109UX44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

45286:AW171 hschr31807
gene id: 45286:AW171_hschr31807
uniprot id: A0A0X8HR68
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

45286:AW171 hschr84581
gene id: 45286:AW171_hschr84581
uniprot id: A0A120K2T4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42.

45286:AW171 hschr53257
gene id: 45286:AW171_hschr53257
uniprot id: A0A109UZG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

45286:AW171 hschr2207
gene id: 45286:AW171_hschr2207
uniprot id: A0A120K0U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

45286:AW171 hschr63759
gene id: 45286:AW171_hschr63759
uniprot id: A0A0X8HUK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC24 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

45286:AW171 hschr74320
gene id: 45286:AW171_hschr74320
uniprot id: A0A0X8HVK6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

45286:AW171 hschr74484
gene id: 45286:AW171_hschr74484
uniprot id: A0A0X8HVT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Component of the FACT complex.
messages: Nucleus

45286:AW171 hschr63907
gene id: 45286:AW171_hschr63907
uniprot id: A0A0X8HUX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck

45286:AW171 hschr53236
gene id: 45286:AW171_hschr53236
uniprot id: A0A0X8HTM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWC5 family.
messages: Component of the SWR1 chromatin remodeling complex.
messages: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.
messages: Nucleus

45286:AW171 hschr2244
gene id: 45286:AW171_hschr2244
uniprot id: A0A109UWE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
messages: Belongs to the DNA polymerase alpha subunit B family.
messages: Nucleus

45286:AW171 hschr21020
gene id: 45286:AW171_hschr21020
uniprot id: A0A120K1A9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

45286:AW171 hschr42821
gene id: 45286:AW171_hschr42821
uniprot id: A0A0X8HT11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.

45286:AW171 hschr42595
gene id: 45286:AW171_hschr42595
uniprot id: A0A0X8HSM1
names: Function
names: Similarity
messages: Belongs to the RRG8 family.
messages: Required for respiratory activity and maintenance and expression of the mitochondrial genome.

45286:AW171 hschr31841
gene id: 45286:AW171_hschr31841
uniprot id: A0A0X8HR91
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

45286:AW171 hschr2852
gene id: 45286:AW171_hschr2852
uniprot id: A0A109UX13
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr42735
gene id: 45286:AW171_hschr42735
uniprot id: A0A109UZ45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

45286:AW171 hschr2314
gene id: 45286:AW171_hschr2314
uniprot id: A0A120K0X8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: srp72, srp68, srp54, sec65, srp21 and srp14.
messages: Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes. SRP54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit SRP101. Both, SRP54 and SRP101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon). After signal sequence transfer, SRP54 and SRP101 act as reciprocal GTPase-activating proteins (GAPs), thereby resolving their association.
messages: The M domain binds the 7SL RNA and the signal sequence of presecretory proteins.
messages: The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit srp101. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

45286:AW171 hschr74235
gene id: 45286:AW171_hschr74235
uniprot id: A0A0X8HUY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr42239
gene id: 45286:AW171_hschr42239
uniprot id: A0A0X8HRX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRE9/KNH1 family.
messages: Involved in cell wall beta(1->6) glucan synthesis.
messages: cell wall

45286:AW171 hschr21142
gene id: 45286:AW171_hschr21142
uniprot id: A0A109UXV5
names: Similarity
messages: Belongs to the peptidase M28 family. M28A subfamily.

45286:AW171 hschr85030
gene id: 45286:AW171_hschr85030
uniprot id: A0A0X8HWX9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Mitochondrion intermembrane space
messages: Monomer.
messages: cytosol

45286:AW171 hschr84547
gene id: 45286:AW171_hschr84547
uniprot id: A0A109V0A1
names: Similarity
messages: Belongs to the V-ATPase D subunit family.

45286:AW171 hschr21263
gene id: 45286:AW171_hschr21263
uniprot id: A0A109UXT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAP1 family.
messages: Homodimer.
messages: Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE).
messages: Nucleus
messages: telomere

45286:AW171 hschr85024
gene id: 45286:AW171_hschr85024
uniprot id: A0A109V159
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

45286:AW171 hschr42630
gene id: 45286:AW171_hschr42630
uniprot id: A0A0X8HSR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Membrane
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.

45286:AW171 hschr31402
gene id: 45286:AW171_hschr31402
uniprot id: A0A109UXW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

45286:AW171 hschr42486
gene id: 45286:AW171_hschr42486
uniprot id: A0A0X8HS99
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

45286:AW171 hschr53438
gene id: 45286:AW171_hschr53438
uniprot id: A0A0X8HU48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 63 family.
messages: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
messages: Endoplasmic reticulum membrane

45286:AW171 hschr42270
gene id: 45286:AW171_hschr42270
uniprot id: A0A0X8HS35
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

45286:AW171 hschr63711
gene id: 45286:AW171_hschr63711
uniprot id: A0A0X8HUP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

45286:AW171 hschr234
gene id: 45286:AW171_hschr234
uniprot id: A0A125RDT3
names: Similarity
messages: Belongs to the heat shock protein 70 family.

45286:AW171 hschr42684
gene id: 45286:AW171_hschr42684
uniprot id: A0A0X8HSS3
names: Similarity
messages: Belongs to the CWC21 family.

45286:AW171 hschr74395
gene id: 45286:AW171_hschr74395
uniprot id: A0A0X8HV88
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

45286:AW171 hschr21050
gene id: 45286:AW171_hschr21050
uniprot id: A0A109UX93
names: Similarity
messages: Belongs to the ketopantoate reductase family.

45286:AW171 hschr31374
gene id: 45286:AW171_hschr31374
uniprot id: A0A109UVW9
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr74059
gene id: 45286:AW171_hschr74059
uniprot id: A0A109UZZ3
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

45286:AW171 hschr42754
gene id: 45286:AW171_hschr42754
uniprot id: A0A109UZ74
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

45286:AW171 hschr32007
gene id: 45286:AW171_hschr32007
uniprot id: A0A0X8HRL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF4 family.
messages: Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
messages: Nucleus

45286:AW171 hschr32050
gene id: 45286:AW171_hschr32050
uniprot id: A0A0X8HRM4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.

45286:AW171 hschr2917
gene id: 45286:AW171_hschr2917
uniprot id: A0A109UX02
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr42856
gene id: 45286:AW171_hschr42856
uniprot id: A0A0X8HT28
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

45286:AW171 hschr52907
gene id: 45286:AW171_hschr52907
uniprot id: A0A0X8HT79
names: Similarity
messages: Belongs to the VPS54 family.

45286:AW171 hschr84924
gene id: 45286:AW171_hschr84924
uniprot id: A0A0X8HWS6
names: Similarity
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.

45286:AW171 hschr2262
gene id: 45286:AW171_hschr2262
uniprot id: A0A109UWA2
names: Function
names: Similarity
messages: Belongs to the SEC8 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

45286:AW171 hschr2860
gene id: 45286:AW171_hschr2860
uniprot id: A0A120K163
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

45286:AW171 hschr53380
gene id: 45286:AW171_hschr53380
uniprot id: A0A0X8HTY6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

45286:AW171 hschr84885
gene id: 45286:AW171_hschr84885
uniprot id: A0A0X8HW62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRG9 family.
messages: Mitochondrion
messages: Required for respiratory activity and maintenance and expression of the mitochondrial genome.

45286:AW171 hschr53384
gene id: 45286:AW171_hschr53384
uniprot id: A0A109UZQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Golgi apparatus membrane
messages: Membrane

45286:AW171 hschr21097
gene id: 45286:AW171_hschr21097
uniprot id: A0A120K1D8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proteasome subunit S5B/HSM3 family.
messages: Cytoplasm
messages: Involved in DNA mismatch repair in slow-growing cells. Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC).

45286:AW171 hschr52955
gene id: 45286:AW171_hschr52955
uniprot id: A0A0X8HT44
names: Function
names: Similarity
messages: Belongs to the VPS13 family.
messages: Mediates the transfer of lipids between membranes at organelle contact sites. May play a role in mitochondrial lipid homeostasis.

45286:AW171 hschr74307
gene id: 45286:AW171_hschr74307
uniprot id: A0A0X8HVI1
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

45286:AW171 hschr2109
gene id: 45286:AW171_hschr2109
uniprot id: A0A120K0S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP11 family.
messages: Mitochondrion

45286:AW171 hschr42807
gene id: 45286:AW171_hschr42807
uniprot id: A0A0X8HSY7
names: Similarity
messages: Belongs to the multicopper oxidase family.

45286:AW171 hschr42293
gene id: 45286:AW171_hschr42293
uniprot id: A0A109UWW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG13 family. Fungi subfamily.
messages: Preautophagosomal structure

45286:AW171 hschr21175
gene id: 45286:AW171_hschr21175
uniprot id: A0A109UXI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
messages: Mitochondrion

45286:AW171 hschr63974
gene id: 45286:AW171_hschr63974
uniprot id: A0A109UZU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit C family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

45286:AW171 hschr53320
gene id: 45286:AW171_hschr53320
uniprot id: A0A0X8HTU6
names: Similarity
messages: Belongs to the TYW1 family.

45286:AW171 hschr63537
gene id: 45286:AW171_hschr63537
uniprot id: A0A0X8HUC4
names: Similarity
messages: Belongs to the actin family.

45286:AW171 hschr63697
gene id: 45286:AW171_hschr63697
uniprot id: A0A0X8HUI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

45286:AW171 hschr31901
gene id: 45286:AW171_hschr31901
uniprot id: A0A0X8HRC3
names: Similarity
messages: Belongs to the acetolactate synthase small subunit family.

45286:AW171 hschr42489
gene id: 45286:AW171_hschr42489
uniprot id: A0A0X8HSD0
names: Similarity
messages: Belongs to the TRM112 family.

45286:AW171 hschr2266
gene id: 45286:AW171_hschr2266
uniprot id: A0A120K0W4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EXO84 family.
messages: Vesicle
messages: secretory vesicle

45286:AW171 hschr31461
gene id: 45286:AW171_hschr31461
uniprot id: A0A120K1P8
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

45286:AW171 hschr31899
gene id: 45286:AW171_hschr31899
uniprot id: A0A0X8HRD6
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr63582
gene id: 45286:AW171_hschr63582
uniprot id: A0A0X8HUC7
names: Similarity
messages: Belongs to the universal ribosomal protein uS13 family.

45286:AW171 hschr74155
gene id: 45286:AW171_hschr74155
uniprot id: A0A109UZX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. ECO subfamily.
messages: Nucleus

45286:AW171 hschr74039
gene id: 45286:AW171_hschr74039
uniprot id: A0A0X8HUK7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the profilin family.
messages: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.
messages: Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

45286:AW171 hschr42236
gene id: 45286:AW171_hschr42236
uniprot id: A0A0X8HRV2
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

45286:AW171 hschr21125
gene id: 45286:AW171_hschr21125
uniprot id: A0A109UXU6
names: Similarity
messages: Belongs to the peptidase M20A family.

45286:AW171 hschr31935
gene id: 45286:AW171_hschr31935
uniprot id: A0A0X8HRF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Endosome membrane
messages: Membrane

45286:AW171 hschr84717
gene id: 45286:AW171_hschr84717
uniprot id: A0A120K2V2
names: Similarity
messages: Belongs to the XPO2/CSE1 family.

45286:AW171 hschr42733
gene id: 45286:AW171_hschr42733
uniprot id: A0A0X8HS29
names: Subcellular Location Annotation
messages: Nucleus

45286:AW171 hschr74135
gene id: 45286:AW171_hschr74135
uniprot id: A0A0X8HVA7
names: Similarity
messages: Belongs to the SF3A3 family.

45286:AW171 hschr53102
gene id: 45286:AW171_hschr53102
uniprot id: A0A0X8HTI1
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

45286:AW171 hschr31834
gene id: 45286:AW171_hschr31834
uniprot id: A0A0X8HR79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the calcineurin regulatory subunit family.
messages: Composed of a catalytic subunit (A) and a regulatory subunit (B).
messages: Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

45286:AW171 hschr31692
gene id: 45286:AW171_hschr31692
uniprot id: A0A109UYF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Mitochondrion inner membrane

45286:AW171 hschr84665
gene id: 45286:AW171_hschr84665
uniprot id: A0A0X8HW81
names: Similarity
messages: Belongs to the CWC26 family.

45286:AW171 hschr84601
gene id: 45286:AW171_hschr84601
uniprot id: A0A0X8HW09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 12 family.
messages: Nucleus

45286:AW171 hschr31854
gene id: 45286:AW171_hschr31854
uniprot id: A0A0X8HR93
names: Function
names: Similarity
messages: Belongs to the RGI1 family.
messages: Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions.

45286:AW171 hschr42099
gene id: 45286:AW171_hschr42099
uniprot id: A0A0X8HRP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

45286:AW171 hschr74267
gene id: 45286:AW171_hschr74267
uniprot id: A0A0X8HVI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr31888
gene id: 45286:AW171_hschr31888
uniprot id: A0A0X8HRC4
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

45286:AW171 hschr63929
gene id: 45286:AW171_hschr63929
uniprot id: A0A109UZW3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
messages: Mitochondrion inner membrane

45286:AW171 hschr53178
gene id: 45286:AW171_hschr53178
uniprot id: A0A109V029
names: Similarity
messages: Belongs to the WD repeat mio family.

45286:AW171 hschr74154
gene id: 45286:AW171_hschr74154
uniprot id: A0A0X8HVB4
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

45286:AW171 hschr63926
gene id: 45286:AW171_hschr63926
uniprot id: A0A0X8HUU0
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

45286:AW171 hschr2842
gene id: 45286:AW171_hschr2842
uniprot id: A0A109UWV7
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

45286:AW171 hschr2892
gene id: 45286:AW171_hschr2892
uniprot id: A0A120K175
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr31819
gene id: 45286:AW171_hschr31819
uniprot id: A0A0X8HR71
names: Similarity
messages: Belongs to the Mo25 family.

45286:AW171 hschr287
gene id: 45286:AW171_hschr287
uniprot id: A0A125RDU0
names: Function
names: Similarity
messages: Belongs to the misato family.
messages: Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.

45286:AW171 hschr63982
gene id: 45286:AW171_hschr63982
uniprot id: A0A0X8HV57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 48 family.
messages: Membrane

45286:AW171 hschr84630
gene id: 45286:AW171_hschr84630
uniprot id: A0A0X8HW35
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SGF11 family.
messages: Component of the 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5 distinct domains with specialized functions. Within the SAGA complex, SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with SGF73, SUS1 and UBP8.
messages: Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). Involved in transcriptional regulation of a subset of SAGA-regulated genes. Within the SAGA complex, participates in a subcomplex, that specifically deubiquitinates histones H2B.
messages: Nucleus
messages: The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of UBP8 forms the 'catalytic lobe' of the SAGA deubiquitination module.
messages: The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module.

45286:AW171 hschr31472
gene id: 45286:AW171_hschr31472
uniprot id: A0A109UY09
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

45286:AW171 hschr42647
gene id: 45286:AW171_hschr42647
uniprot id: A0A0X8HSM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDOST 48 kDa subunit family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).

45286:AW171 hschr2206
gene id: 45286:AW171_hschr2206
uniprot id: A0A109UW64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

45286:AW171 hschr42247
gene id: 45286:AW171_hschr42247
uniprot id: A0A109UZ77
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr84803
gene id: 45286:AW171_hschr84803
uniprot id: A0A0X8HWH1
names: Similarity
messages: Belongs to the LTV1 family.

45286:AW171 hschr63757
gene id: 45286:AW171_hschr63757
uniprot id: A0A0X8HUL5
names: Similarity
messages: Belongs to the protein kinase superfamily.

45286:AW171 hschr63748
gene id: 45286:AW171_hschr63748
uniprot id: A0A0X8HTY3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

45286:AW171 hschr2432
gene id: 45286:AW171_hschr2432
uniprot id: A0A109UWP4
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr84678
gene id: 45286:AW171_hschr84678
uniprot id: A0A0X8HWD1
names: Similarity
messages: Belongs to the AAR2 family.

45286:AW171 hschr31925
gene id: 45286:AW171_hschr31925
uniprot id: A0A120K209
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

45286:AW171 hschr31482
gene id: 45286:AW171_hschr31482
uniprot id: A0A109UW44
names: Subcellular Location Annotation
messages: Peroxisome membrane

45286:AW171 hschr42183
gene id: 45286:AW171_hschr42183
uniprot id: A0A109UWU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Component of the GSE complex.
messages: GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.

45286:AW171 hschr42337
gene id: 45286:AW171_hschr42337
uniprot id: A0A0X8HS34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIP1 family.
messages: Nucleus

45286:AW171 hschr53176
gene id: 45286:AW171_hschr53176
uniprot id: A0A109UZG7
names: Similarity
messages: Belongs to the WD repeat L(2)GL family.

45286:AW171 hschr2835
gene id: 45286:AW171_hschr2835
uniprot id: A0A125RDZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC2/Nipped-B family.
messages: Nucleus

45286:AW171 hschr21073
gene id: 45286:AW171_hschr21073
uniprot id: A0A125RE30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

45286:AW171 hschr2183
gene id: 45286:AW171_hschr2183
uniprot id: A0A109UW48
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

45286:AW171 hschr84780
gene id: 45286:AW171_hschr84780
uniprot id: A0A109V110
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

45286:AW171 hschr31389
gene id: 45286:AW171_hschr31389
uniprot id: A0A109UVX9
names: Similarity
messages: Belongs to the UFD1 family.

45286:AW171 hschr283
gene id: 45286:AW171_hschr283
uniprot id: A0A125RDT9
names: Similarity
messages: Belongs to the CEF1 family.

45286:AW171 hschr84800
gene id: 45286:AW171_hschr84800
uniprot id: A0A0X8HWD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Vacuole membrane

45286:AW171 hschr53113
gene id: 45286:AW171_hschr53113
uniprot id: A0A0X8HTG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: microtubule organizing center

45286:AW171 hschr74073
gene id: 45286:AW171_hschr74073
uniprot id: A0A109V059
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr63613
gene id: 45286:AW171_hschr63613
uniprot id: A0A0X8HUD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit G family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.

45286:AW171 hschr31332
gene id: 45286:AW171_hschr31332
uniprot id: A0A109UXV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR1 family.
messages: Membrane

45286:AW171 hschr2230
gene id: 45286:AW171_hschr2230
uniprot id: A0A109UWC0
names: Similarity
messages: Belongs to the CBF/MAK21 family.

45286:AW171 hschr74485
gene id: 45286:AW171_hschr74485
uniprot id: A0A0X8HW08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

45286:AW171 hschr63561
gene id: 45286:AW171_hschr63561
uniprot id: A0A109UZI8
names: Similarity
messages: Belongs to the DEAD box helicase family.

45286:AW171 hschr63574
gene id: 45286:AW171_hschr63574
uniprot id: A0A0X8HTM7
names: Similarity
messages: Belongs to the RAD52 family.

45286:AW171 hschr42126
gene id: 45286:AW171_hschr42126
uniprot id: A0A0X8HRS2
names: Similarity
messages: Belongs to the glycosyl hydrolase 76 family.

45286:AW171 hschr53244
gene id: 45286:AW171_hschr53244
uniprot id: A0A109UZE3
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr53323
gene id: 45286:AW171_hschr53323
uniprot id: A0A109UZD9
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

45286:AW171 hschr2149
gene id: 45286:AW171_hschr2149
uniprot id: A0A125RDU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

45286:AW171 hschr42438
gene id: 45286:AW171_hschr42438
uniprot id: A0A0X8HSE7
names: Similarity
messages: Belongs to the cyclin family.

45286:AW171 hschr32033
gene id: 45286:AW171_hschr32033
uniprot id: A0A0X8HQK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Nucleus

45286:AW171 hschr53225
gene id: 45286:AW171_hschr53225
uniprot id: A0A109UZC2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

45286:AW171 hschr21203
gene id: 45286:AW171_hschr21203
uniprot id: A0A109UVL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

45286:AW171 hschr74099
gene id: 45286:AW171_hschr74099
uniprot id: A0A0X8HVB0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

45286:AW171 hschr42431
gene id: 45286:AW171_hschr42431
uniprot id: A0A109UWZ5
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

45286:AW171 hschr53162
gene id: 45286:AW171_hschr53162
uniprot id: A0A120K2E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPF2 family.
messages: nucleolus

45286:AW171 hschr42330
gene id: 45286:AW171_hschr42330
uniprot id: A0A0X8HS09
names: Similarity
messages: Belongs to the peptidase C12 family.

45286:AW171 hschr2855
gene id: 45286:AW171_hschr2855
uniprot id: A0A109UWV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OSBP family.
messages: Membrane

45286:AW171 hschr31917
gene id: 45286:AW171_hschr31917
uniprot id: A0A0X8HRD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

45286:AW171 hschr53085
gene id: 45286:AW171_hschr53085
uniprot id: A0A109UXC8
names: Similarity
messages: Belongs to the TMA16 family.

45286:AW171 hschr42627
gene id: 45286:AW171_hschr42627
uniprot id: A0A0X8HSN7
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

45286:AW171 hschr2983
gene id: 45286:AW171_hschr2983
uniprot id: A0A120K1A0
names: Subcellular Location Annotation
messages: Membrane

45286:AW171 hschr2973
gene id: 45286:AW171_hschr2973
uniprot id: A0A120K193
names: Function
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Regulatory subunit of casein kinase II/CK2 (By similarity). As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
messages: Tetramer of two alpha and two beta subunits.

45286:AW171 hschr21179
gene id: 45286:AW171_hschr21179
uniprot id: A0A120K1G3
names: Similarity
messages: Belongs to the ERT1/acuK family.

45286:AW171 hschr31609
gene id: 45286:AW171_hschr31609
uniprot id: A0A109UY80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YSP2 family.
messages: Membrane