446860:AS188 RS13905
gene id: 446860:AS188_RS13905
uniprot id: A0A0U3HYS1
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

446860:AS188 RS10970
gene id: 446860:AS188_RS10970
uniprot id: A0A0U3HH77
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

446860:AS188 RS02970
gene id: 446860:AS188_RS02970
uniprot id: A0A0U2NXA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446860:AS188 RS13950
gene id: 446860:AS188_RS13950
uniprot id: A0A0U3HIG2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

446860:AS188 RS03470
gene id: 446860:AS188_RS03470
uniprot id: A0A0U3HUD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Membrane

446860:AS188 RS13810
gene id: 446860:AS188_RS13810
uniprot id: A0A0U2YYU9
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

446860:AS188 RS15010
gene id: 446860:AS188_RS15010
uniprot id: A0A0U3HD07
names: Similarity
messages: Belongs to the GARS family.

446860:AS188 RS12935
gene id: 446860:AS188_RS12935
uniprot id: A0A0U2P0Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

446860:AS188 RS06540
gene id: 446860:AS188_RS06540
uniprot id: A0A0U3G3E1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

446860:AS188 RS13740
gene id: 446860:AS188_RS13740
uniprot id: A0A0U3HCH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

446860:AS188 RS13600
gene id: 446860:AS188_RS13600
uniprot id: A0A0U3HYV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

446860:AS188 RS08840
gene id: 446860:AS188_RS08840
uniprot id: A0A0U3G9R1
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

446860:AS188 RS12780
gene id: 446860:AS188_RS12780
uniprot id: A0A0U2XQK2
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

446860:AS188 RS02690
gene id: 446860:AS188_RS02690
uniprot id: A0A0U3HTR2
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-76 and Arg-79) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.

446860:AS188 RS11280
gene id: 446860:AS188_RS11280
uniprot id: A0A0U3I9Z9
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS05770
gene id: 446860:AS188_RS05770
uniprot id: A0A0U3GGU2
names: Similarity
messages: Belongs to the peptidase M18 family.

446860:AS188 RS11240
gene id: 446860:AS188_RS11240
uniprot id: A0A0U3HJZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

446860:AS188 RS12525
gene id: 446860:AS188_RS12525
uniprot id: A0A0U2P0U8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

446860:AS188 RS14705
gene id: 446860:AS188_RS14705
uniprot id: A0A0U2XRF2
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

446860:AS188 RS08880
gene id: 446860:AS188_RS08880
uniprot id: A0A0U2XNN0
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

446860:AS188 RS04330
gene id: 446860:AS188_RS04330
uniprot id: A0A0U3GIC3
names: Similarity
messages: Belongs to the four-carbon acid sugar kinase family.

446860:AS188 RS06735
gene id: 446860:AS188_RS06735
uniprot id: A0A0U3I817
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Gfo/Idh/MocA family.
messages: Homotetramer.
messages: Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).

446860:AS188 RS11705
gene id: 446860:AS188_RS11705
uniprot id: A0A0U3G666
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS08620
gene id: 446860:AS188_RS08620
uniprot id: A0A0U3G4L1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

446860:AS188 RS11890
gene id: 446860:AS188_RS11890
uniprot id: A0A0U3HS48
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

446860:AS188 RS01800
gene id: 446860:AS188_RS01800
uniprot id: A0A0U3GH47
names: Function
messages: TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to TetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter operator sites.

446860:AS188 RS01755
gene id: 446860:AS188_RS01755
uniprot id: A0A0U3G6A2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

446860:AS188 RS09635
gene id: 446860:AS188_RS09635
uniprot id: A0A0U3G538
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

446860:AS188 RS13210
gene id: 446860:AS188_RS13210
uniprot id: A0A0U3HSK0
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

446860:AS188 RS14010
gene id: 446860:AS188_RS14010
uniprot id: A0A0U2WWF2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

446860:AS188 RS12705
gene id: 446860:AS188_RS12705
uniprot id: A0A0U3HSC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

446860:AS188 RS14605
gene id: 446860:AS188_RS14605
uniprot id: A0A0U3HT57
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

446860:AS188 RS17385
gene id: 446860:AS188_RS17385
uniprot id: A0A0U3H8N9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrgA family.
messages: Cell membrane
messages: Involved in cell division.

446860:AS188 RS13775
gene id: 446860:AS188_RS13775
uniprot id: A0A0U3GC02
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

446860:AS188 RS14615
gene id: 446860:AS188_RS14615
uniprot id: A0A0U3HIR7
names: Similarity
messages: Belongs to the histone deacetylase family.

446860:AS188 RS00605
gene id: 446860:AS188_RS00605
uniprot id: A0A0U3GCX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

446860:AS188 RS08065
gene id: 446860:AS188_RS08065
uniprot id: A0A0U3HU40
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

446860:AS188 RS11110
gene id: 446860:AS188_RS11110
uniprot id: A0A0U3HXV4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS06115
gene id: 446860:AS188_RS06115
uniprot id: A0A0U2WSB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DisA family.
messages: Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process.
messages: Homooctamer.
messages: Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions.

446860:AS188 RS06520
gene id: 446860:AS188_RS06520
uniprot id: A0A0U3HPJ2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

446860:AS188 RS12155
gene id: 446860:AS188_RS12155
uniprot id: A0A0U3HXZ9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

446860:AS188 RS09435
gene id: 446860:AS188_RS09435
uniprot id: A0A0U3G503
names: Similarity
messages: Belongs to the glutamate synthase family.

446860:AS188 RS06695
gene id: 446860:AS188_RS06695
uniprot id: A0A0U2WSM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

446860:AS188 RS06920
gene id: 446860:AS188_RS06920
uniprot id: A0A0U3I1L6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

446860:AS188 RS09825
gene id: 446860:AS188_RS09825
uniprot id: A0A0U3HGP9
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

446860:AS188 RS08420
gene id: 446860:AS188_RS08420
uniprot id: A0A0U2XSL7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

446860:AS188 RS03105
gene id: 446860:AS188_RS03105
uniprot id: A0A0U3GHN8
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

446860:AS188 RS12980
gene id: 446860:AS188_RS12980
uniprot id: A0A0U2WVY3
names: Similarity
messages: Belongs to the GSP E family.

446860:AS188 RS02095
gene id: 446860:AS188_RS02095
uniprot id: A0A0U2YT89
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

446860:AS188 RS00885
gene id: 446860:AS188_RS00885
uniprot id: A0A0U3GET0
names: Similarity
messages: Belongs to the PheA/TfdB FAD monooxygenase family.

446860:AS188 RS05385
gene id: 446860:AS188_RS05385
uniprot id: A0A0U3HV80
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

446860:AS188 RS06955
gene id: 446860:AS188_RS06955
uniprot id: A0A0U3HW33
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

446860:AS188 RS14525
gene id: 446860:AS188_RS14525
uniprot id: A0A0U3I0N3
names: Similarity
messages: Belongs to the class-D beta-lactamase family.

446860:AS188 RS06680
gene id: 446860:AS188_RS06680
uniprot id: A0A0U2YVC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

446860:AS188 RS11285
gene id: 446860:AS188_RS11285
uniprot id: A0A0U2P0D1
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Homodimer.

446860:AS188 RS02390
gene id: 446860:AS188_RS02390
uniprot id: A0A0U3GHD6
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS12365
gene id: 446860:AS188_RS12365
uniprot id: A0A0U2YY65
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

446860:AS188 RS14330
gene id: 446860:AS188_RS14330
uniprot id: A0A0U3HIM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.

446860:AS188 RS09705
gene id: 446860:AS188_RS09705
uniprot id: A0A0U2WUC4
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

446860:AS188 RS11945
gene id: 446860:AS188_RS11945
uniprot id: A0A0U3HXX3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

446860:AS188 RS00275
gene id: 446860:AS188_RS00275
uniprot id: A0A0U3HCF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family.
messages: Cell membrane
messages: Membrane

446860:AS188 RS06675
gene id: 446860:AS188_RS06675
uniprot id: A0A0U3HVZ0
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

446860:AS188 RS06805
gene id: 446860:AS188_RS06805
uniprot id: A0A0U3HX74
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

446860:AS188 RS07435
gene id: 446860:AS188_RS07435
uniprot id: A0A0U3G948
names: Similarity
messages: Belongs to the 3-hydroxybenzoate 6-hydroxylase family.

446860:AS188 RS02585
gene id: 446860:AS188_RS02585
uniprot id: A0A0U2XKC7
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

446860:AS188 RS07070
gene id: 446860:AS188_RS07070
uniprot id: A0A0U2YVI9
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

446860:AS188 RS08260
gene id: 446860:AS188_RS08260
uniprot id: A0A0U3GKD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

446860:AS188 RS02255
gene id: 446860:AS188_RS02255
uniprot id: A0A0U2NX19
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

446860:AS188 RS15105
gene id: 446860:AS188_RS15105
uniprot id: A0A0U3GNR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane
messages: Membrane

446860:AS188 RS08600
gene id: 446860:AS188_RS08600
uniprot id: A0A0U3HY11
names: Similarity
messages: Belongs to the peptidase M1 family.

446860:AS188 RS12940
gene id: 446860:AS188_RS12940
uniprot id: A0A0U3GK24
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

446860:AS188 RS05870
gene id: 446860:AS188_RS05870
uniprot id: A0A0U2NYD6
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS00300
gene id: 446860:AS188_RS00300
uniprot id: A0A0U2NW70
names: Similarity
messages: Belongs to the TPP enzyme family.

446860:AS188 RS12685
gene id: 446860:AS188_RS12685
uniprot id: A0A0U3HK30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

446860:AS188 RS00255
gene id: 446860:AS188_RS00255
uniprot id: A0A0U2WP86
names: Similarity
messages: Belongs to the peptidase C56 family.

446860:AS188 RS06590
gene id: 446860:AS188_RS06590
uniprot id: A0A0U3GJF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

446860:AS188 RS14740
gene id: 446860:AS188_RS14740
uniprot id: A0A0U3HIT2
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS12010
gene id: 446860:AS188_RS12010
uniprot id: A0A0U3I280
names: Similarity
messages: Belongs to the truncated hemoglobin family. Group II subfamily.

446860:AS188 RS15835
gene id: 446860:AS188_RS15835
uniprot id: A0A0U2Z0U6
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

446860:AS188 RS11195
gene id: 446860:AS188_RS11195
uniprot id: A0A0U3HXL0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

446860:AS188 RS11325
gene id: 446860:AS188_RS11325
uniprot id: A0A0U3HBE2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

446860:AS188 RS02545
gene id: 446860:AS188_RS02545
uniprot id: A0A0U3I616
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS05775
gene id: 446860:AS188_RS05775
uniprot id: A0A0U3HVE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm

446860:AS188 RS05455
gene id: 446860:AS188_RS05455
uniprot id: A0A0U3G2V4
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

446860:AS188 RS10660
gene id: 446860:AS188_RS10660
uniprot id: A0A0U2YXA8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

446860:AS188 RS05970
gene id: 446860:AS188_RS05970
uniprot id: A0A0U2Z035
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446860:AS188 RS11215
gene id: 446860:AS188_RS11215
uniprot id: A0A0U2YXK5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

446860:AS188 RS01860
gene id: 446860:AS188_RS01860
uniprot id: A0A0U3GF88
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS06025
gene id: 446860:AS188_RS06025
uniprot id: A0A0U3HEZ5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS00840
gene id: 446860:AS188_RS00840
uniprot id: A0A0U2YZR7
names: Function
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: May catalyze the transamination reaction in phenylalanine biosynthesis.

446860:AS188 RS01865
gene id: 446860:AS188_RS01865
uniprot id: A0A0U3HTQ9
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS11010
gene id: 446860:AS188_RS11010
uniprot id: A0A0U3HXH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

446860:AS188 RS08590
gene id: 446860:AS188_RS08590
uniprot id: A0A0U3HA47
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

446860:AS188 RS14505
gene id: 446860:AS188_RS14505
uniprot id: A0A0U3GDV9
names: Cofactor
messages: Can also use Mn(2+) ion.

446860:AS188 RS07990
gene id: 446860:AS188_RS07990
uniprot id: A0A0U3H9S3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

446860:AS188 RS12880
gene id: 446860:AS188_RS12880
uniprot id: A0A0U3GMQ6
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS12690
gene id: 446860:AS188_RS12690
uniprot id: A0A0U2WVT9
names: Subcellular Location Annotation
messages: Cytoplasm

446860:AS188 RS08530
gene id: 446860:AS188_RS08530
uniprot id: A0A0U3G4J4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

446860:AS188 RS05655
gene id: 446860:AS188_RS05655
uniprot id: A0A0U3G2Y7
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS04625
gene id: 446860:AS188_RS04625
uniprot id: A0A0U3HNM0
names: Similarity
messages: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.

446860:AS188 RS05060
gene id: 446860:AS188_RS05060
uniprot id: A0A0U3I7H9
names: Similarity
messages: Belongs to the TPP enzyme family.

446860:AS188 RS03615
gene id: 446860:AS188_RS03615
uniprot id: A0A0U3HCT2
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS07090
gene id: 446860:AS188_RS07090
uniprot id: A0A0U2WSX6
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS09640
gene id: 446860:AS188_RS09640
uniprot id: A0A0U3GA29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

446860:AS188 RS02750
gene id: 446860:AS188_RS02750
uniprot id: A0A0U3G1J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

446860:AS188 RS12520
gene id: 446860:AS188_RS12520
uniprot id: A0A0U3IAK9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS09760
gene id: 446860:AS188_RS09760
uniprot id: A0A0U2NZU0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

446860:AS188 RS00975
gene id: 446860:AS188_RS00975
uniprot id: A0A0U2NWF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UreE family.
messages: Cytoplasm
messages: Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.

446860:AS188 RS11330
gene id: 446860:AS188_RS11330
uniprot id: A0A0U3G8X2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

446860:AS188 RS01365
gene id: 446860:AS188_RS01365
uniprot id: A0A0U3G616
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

446860:AS188 RS01495
gene id: 446860:AS188_RS01495
uniprot id: A0A0U2NWM7
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

446860:AS188 RS13015
gene id: 446860:AS188_RS13015
uniprot id: A0A0U3G6U8
names: Similarity
messages: Belongs to the UDP-galactopyranose/dTDP-fucopyranose mutase family.

446860:AS188 RS04925
gene id: 446860:AS188_RS04925
uniprot id: A0A0U3HNR7
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

446860:AS188 RS11355
gene id: 446860:AS188_RS11355
uniprot id: A0A0U3HGG2
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS14060
gene id: 446860:AS188_RS14060
uniprot id: A0A0U3GKF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

446860:AS188 RS02935
gene id: 446860:AS188_RS02935
uniprot id: A0A0U3HMQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

446860:AS188 RS08790
gene id: 446860:AS188_RS08790
uniprot id: A0A0U3GKR6
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS08430
gene id: 446860:AS188_RS08430
uniprot id: A0A0U2WXZ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

446860:AS188 RS09345
gene id: 446860:AS188_RS09345
uniprot id: A0A0U3I969
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

446860:AS188 RS01765
gene id: 446860:AS188_RS01765
uniprot id: A0A0U2NWU7
names: Similarity
messages: Belongs to the universal stress protein A family.

446860:AS188 RS04905
gene id: 446860:AS188_RS04905
uniprot id: A0A0U2XLH2
names: Similarity
messages: Belongs to the hyi family.

446860:AS188 RS09570
gene id: 446860:AS188_RS09570
uniprot id: A0A0U3HX91
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS12840
gene id: 446860:AS188_RS12840
uniprot id: A0A0U3IAQ4
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS14125
gene id: 446860:AS188_RS14125
uniprot id: A0A0U3HHN5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

446860:AS188 RS06725
gene id: 446860:AS188_RS06725
uniprot id: A0A0U3G3G7
names: Similarity
messages: Belongs to the TPP enzyme family.

446860:AS188 RS01610
gene id: 446860:AS188_RS01610
uniprot id: A0A0U2WQ53
names: Similarity
messages: Belongs to the pirin family.

446860:AS188 RS02775
gene id: 446860:AS188_RS02775
uniprot id: A0A0U3GFJ6
names: Similarity
messages: Belongs to the TPP enzyme family.

446860:AS188 RS06020
gene id: 446860:AS188_RS06020
uniprot id: A0A0U3HWV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

446860:AS188 RS17720
gene id: 446860:AS188_RS17720
uniprot id: A0A0U3HW06
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

446860:AS188 RS14385
gene id: 446860:AS188_RS14385
uniprot id: A0A0U3HUL2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

446860:AS188 RS01385
gene id: 446860:AS188_RS01385
uniprot id: A0A0U2NWK0
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

446860:AS188 RS06000
gene id: 446860:AS188_RS06000
uniprot id: A0A0U2WSA7
names: Similarity
messages: Belongs to the peptidase S13 family.

446860:AS188 RS11130
gene id: 446860:AS188_RS11130
uniprot id: A0A0U3GLV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

446860:AS188 RS04775
gene id: 446860:AS188_RS04775
uniprot id: A0A0U3GGF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

446860:AS188 RS11605
gene id: 446860:AS188_RS11605
uniprot id: A0A0U3HHI1
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

446860:AS188 RS07195
gene id: 446860:AS188_RS07195
uniprot id: A0A0U3GJT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Cell membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

446860:AS188 RS04870
gene id: 446860:AS188_RS04870
uniprot id: A0A0U2NY10
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

446860:AS188 RS02720
gene id: 446860:AS188_RS02720
uniprot id: A0A0U3HMM7
names: Similarity
messages: Belongs to the universal stress protein A family.

446860:AS188 RS03945
gene id: 446860:AS188_RS03945
uniprot id: A0A0U3GG12
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

446860:AS188 RS04650
gene id: 446860:AS188_RS04650
uniprot id: A0A0U3G7T7
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS15715
gene id: 446860:AS188_RS15715
uniprot id: A0A0U3I191
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

446860:AS188 RS13935
gene id: 446860:AS188_RS13935
uniprot id: A0A0U3HCL1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

446860:AS188 RS06565
gene id: 446860:AS188_RS06565
uniprot id: A0A0U3GH67
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

446860:AS188 RS12720
gene id: 446860:AS188_RS12720
uniprot id: A0A0U3HH26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

446860:AS188 RS07000
gene id: 446860:AS188_RS07000
uniprot id: A0A0U3HX96
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

446860:AS188 RS08335
gene id: 446860:AS188_RS08335
uniprot id: A0A0U3GHY3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

446860:AS188 RS08525
gene id: 446860:AS188_RS08525
uniprot id: A0A0U3HF61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

446860:AS188 RS05085
gene id: 446860:AS188_RS05085
uniprot id: A0A0U3HVA7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.

446860:AS188 RS11245
gene id: 446860:AS188_RS11245
uniprot id: A0A0U3HRU6
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

446860:AS188 RS08635
gene id: 446860:AS188_RS08635
uniprot id: A0A0U2NZF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

446860:AS188 RS10355
gene id: 446860:AS188_RS10355
uniprot id: A0A0U3I9J7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

446860:AS188 RS00540
gene id: 446860:AS188_RS00540
uniprot id: A0A0U2WPE8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

446860:AS188 RS14545
gene id: 446860:AS188_RS14545
uniprot id: A0A0U3GCC5
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS14345
gene id: 446860:AS188_RS14345
uniprot id: A0A0U3GC97
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS09070
gene id: 446860:AS188_RS09070
uniprot id: A0A0U3HX31
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

446860:AS188 RS10830
gene id: 446860:AS188_RS10830
uniprot id: A0A0U3HXQ7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase-binding protein RbpA family.
messages: Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
messages: Forms a complex with the RNAP catalytic core and with free principal sigma factors.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS14105
gene id: 446860:AS188_RS14105
uniprot id: A0A0U3HSZ5
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

446860:AS188 RS03200
gene id: 446860:AS188_RS03200
uniprot id: A0A0U2WQW9
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

446860:AS188 RS08440
gene id: 446860:AS188_RS08440
uniprot id: A0A0U3G9I7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination.
messages: Homohexamer. Forms a ring that surrounds DNA.
messages: Membrane

446860:AS188 RS17040
gene id: 446860:AS188_RS17040
uniprot id: A0A0U2NWA5
names: Similarity
messages: Belongs to the AHA1 family.

446860:AS188 RS07095
gene id: 446860:AS188_RS07095
uniprot id: A0A0U3H9D2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS01545
gene id: 446860:AS188_RS01545
uniprot id: A0A0U3HUT0
names: Similarity
messages: Belongs to the UPF0225 family.

446860:AS188 RS01135
gene id: 446860:AS188_RS01135
uniprot id: A0A0U3HBN1
names: Similarity
messages: Belongs to the AHA1 family.

446860:AS188 RS06985
gene id: 446860:AS188_RS06985
uniprot id: A0A0U3G8M9
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

446860:AS188 RS07530
gene id: 446860:AS188_RS07530
uniprot id: A0A0U3G960
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

446860:AS188 RS07545
gene id: 446860:AS188_RS07545
uniprot id: A0A0U3GHL4
names: Similarity
messages: Belongs to the universal stress protein A family.

446860:AS188 RS01645
gene id: 446860:AS188_RS01645
uniprot id: A0A0U3G688
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaved by autocatalysis into a large and a small subunit.
messages: This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.

446860:AS188 RS08730
gene id: 446860:AS188_RS08730
uniprot id: A0A0U3HF81
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS12340
gene id: 446860:AS188_RS12340
uniprot id: A0A0U3IAI0
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

446860:AS188 RS05925
gene id: 446860:AS188_RS05925
uniprot id: A0A0U3HWT4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

446860:AS188 RS01090
gene id: 446860:AS188_RS01090
uniprot id: A0A0U3HTM9
names: Similarity
messages: Belongs to the universal stress protein A family.

446860:AS188 RS14080
gene id: 446860:AS188_RS14080
uniprot id: A0A0U2XR63
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit A family.

446860:AS188 RS01720
gene id: 446860:AS188_RS01720
uniprot id: A0A0U3HM61
names: Similarity
messages: Belongs to the CsoR family.

446860:AS188 RS01750
gene id: 446860:AS188_RS01750
uniprot id: A0A0U3G0Y8
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

446860:AS188 RS07965
gene id: 446860:AS188_RS07965
uniprot id: A0A0U2YVZ8
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS03610
gene id: 446860:AS188_RS03610
uniprot id: A0A0U3GD52
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS09915
gene id: 446860:AS188_RS09915
uniprot id: A0A0U3HR76
names: Similarity
messages: Belongs to the NodU/CmcH family.

446860:AS188 RS15170
gene id: 446860:AS188_RS15170
uniprot id: A0A0U3HZC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

446860:AS188 RS00805
gene id: 446860:AS188_RS00805
uniprot id: A0A0U3HTH5
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

446860:AS188 RS14945
gene id: 446860:AS188_RS14945
uniprot id: A0A0U3G7N0
names: Similarity
messages: Belongs to the peptidase A24 family.

446860:AS188 RS14055
gene id: 446860:AS188_RS14055
uniprot id: A0A0U2P1D5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

446860:AS188 RS00995
gene id: 446860:AS188_RS00995
uniprot id: A0A0U2YSR0
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS11315
gene id: 446860:AS188_RS11315
uniprot id: A0A0U3GLZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

446860:AS188 RS09685
gene id: 446860:AS188_RS09685
uniprot id: A0A0U3HXA3
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS00390
gene id: 446860:AS188_RS00390
uniprot id: A0A0U2NW82
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

446860:AS188 RS08945
gene id: 446860:AS188_RS08945
uniprot id: A0A0U2Z0B6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

446860:AS188 RS13710
gene id: 446860:AS188_RS13710
uniprot id: A0A0U3HYN8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS02175
gene id: 446860:AS188_RS02175
uniprot id: A0A0U3GFC9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

446860:AS188 RS01245
gene id: 446860:AS188_RS01245
uniprot id: A0A0U3G0R9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

446860:AS188 RS07750
gene id: 446860:AS188_RS07750
uniprot id: A0A0U3HW92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

446860:AS188 RS08850
gene id: 446860:AS188_RS08850
uniprot id: A0A0U3I905
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

446860:AS188 RS08785
gene id: 446860:AS188_RS08785
uniprot id: A0A0U2XNL8
names: Subcellular Location Annotation
messages: Cytoplasm

446860:AS188 RS08575
gene id: 446860:AS188_RS08575
uniprot id: A0A0U2XNI7
names: Similarity
messages: Belongs to the Nudix hydrolase family.

446860:AS188 RS15410
gene id: 446860:AS188_RS15410
uniprot id: A0A0U3HD68
names: Similarity
messages: Belongs to the LOG family.

446860:AS188 RS00810
gene id: 446860:AS188_RS00810
uniprot id: A0A0U2YSM5
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit A family.

446860:AS188 RS14005
gene id: 446860:AS188_RS14005
uniprot id: A0A0U3GN88
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

446860:AS188 RS04610
gene id: 446860:AS188_RS04610
uniprot id: A0A0U3GII3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

446860:AS188 RS04895
gene id: 446860:AS188_RS04895
uniprot id: A0A0U3HV67
names: Similarity
messages: Belongs to the TPP enzyme family.

446860:AS188 RS02870
gene id: 446860:AS188_RS02870
uniprot id: A0A0U3I6B6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

446860:AS188 RS06875
gene id: 446860:AS188_RS06875
uniprot id: A0A0U3GJM8
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

446860:AS188 RS02765
gene id: 446860:AS188_RS02765
uniprot id: A0A0U3I6A0
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

446860:AS188 RS11165
gene id: 446860:AS188_RS11165
uniprot id: A0A0U3G5W3
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

446860:AS188 RS14185
gene id: 446860:AS188_RS14185
uniprot id: A0A0U2WWI6
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

446860:AS188 RS15810
gene id: 446860:AS188_RS15810
uniprot id: A0A0U2P322
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

446860:AS188 RS08295
gene id: 446860:AS188_RS08295
uniprot id: A0A0U3HF10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

446860:AS188 RS03700
gene id: 446860:AS188_RS03700
uniprot id: A0A0U3HN33
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

446860:AS188 RS02615
gene id: 446860:AS188_RS02615
uniprot id: A0A0U3GP75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446860:AS188 RS13200
gene id: 446860:AS188_RS13200
uniprot id: A0A0U2WW14
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

446860:AS188 RS09560
gene id: 446860:AS188_RS09560
uniprot id: A0A0U3GIG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

446860:AS188 RS14630
gene id: 446860:AS188_RS14630
uniprot id: A0A0U3HHX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

446860:AS188 RS08305
gene id: 446860:AS188_RS08305
uniprot id: A0A0U3G4E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

446860:AS188 RS16210
gene id: 446860:AS188_RS16210
uniprot id: A0A0U3GEC8
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

446860:AS188 RS11070
gene id: 446860:AS188_RS11070
uniprot id: A0A0U3G5U9
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS13190
gene id: 446860:AS188_RS13190
uniprot id: A0A0U3GMV3
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

446860:AS188 RS13295
gene id: 446860:AS188_RS13295
uniprot id: A0A0U3G945
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

446860:AS188 RS00660
gene id: 446860:AS188_RS00660
uniprot id: A0A0U3HCL6
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS11715
gene id: 446860:AS188_RS11715
uniprot id: A0A0U3IA90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane
messages: Membrane

446860:AS188 RS08320
gene id: 446860:AS188_RS08320
uniprot id: A0A0U3G9H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

446860:AS188 RS13975
gene id: 446860:AS188_RS13975
uniprot id: A0A0U2P1C3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

446860:AS188 RS15610
gene id: 446860:AS188_RS15610
uniprot id: A0A0U3I156
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

446860:AS188 RS00765
gene id: 446860:AS188_RS00765
uniprot id: A0A0U3HCM4
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

446860:AS188 RS11925
gene id: 446860:AS188_RS11925
uniprot id: A0A0U3GB50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

446860:AS188 RS06185
gene id: 446860:AS188_RS06185
uniprot id: A0A0U3HVK6
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS13235
gene id: 446860:AS188_RS13235
uniprot id: A0A0U3G6Y3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS07995
gene id: 446860:AS188_RS07995
uniprot id: A0A0U3HQA2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

446860:AS188 RS12315
gene id: 446860:AS188_RS12315
uniprot id: A0A0U3HHT4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

446860:AS188 RS03545
gene id: 446860:AS188_RS03545
uniprot id: A0A0U2NXH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GcvT family.
messages: Cytoplasm

446860:AS188 RS00015
gene id: 446860:AS188_RS00015
uniprot id: A0A0U3G5H8
names: Similarity
messages: Belongs to the bacterial ring-hydroxylating dioxygenase beta subunit family.

446860:AS188 RS12620
gene id: 446860:AS188_RS12620
uniprot id: A0A0U3IAM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

446860:AS188 RS08275
gene id: 446860:AS188_RS08275
uniprot id: A0A0U3H9X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

446860:AS188 RS10150
gene id: 446860:AS188_RS10150
uniprot id: A0A0U3I0J6
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

446860:AS188 RS14380
gene id: 446860:AS188_RS14380
uniprot id: A0A0U2YZ38
names: Similarity
messages: Belongs to the UPF0234 family.

446860:AS188 RS15690
gene id: 446860:AS188_RS15690
uniprot id: A0A0U3HJE4
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

446860:AS188 RS15500
gene id: 446860:AS188_RS15500
uniprot id: A0A0U3GNX7
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS06810
gene id: 446860:AS188_RS06810
uniprot id: A0A0U3HFC2
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS16260
gene id: 446860:AS188_RS16260
uniprot id: A0A0U2WZ17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

446860:AS188 RS08560
gene id: 446860:AS188_RS08560
uniprot id: A0A0U3HWJ4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

446860:AS188 RS07410
gene id: 446860:AS188_RS07410
uniprot id: A0A0U3HXG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

446860:AS188 RS08655
gene id: 446860:AS188_RS08655
uniprot id: A0A0U3HWX3
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS03520
gene id: 446860:AS188_RS03520
uniprot id: A0A0U3HDU2
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS12225
gene id: 446860:AS188_RS12225
uniprot id: A0A0U3HGU7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

446860:AS188 RS10610
gene id: 446860:AS188_RS10610
uniprot id: A0A0U3HYW1
names: Similarity
messages: Belongs to the peptidase S8 family.

446860:AS188 RS09690
gene id: 446860:AS188_RS09690
uniprot id: A0A0U2YWV6
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS13500
gene id: 446860:AS188_RS13500
uniprot id: A0A0U2YYN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

446860:AS188 RS03695
gene id: 446860:AS188_RS03695
uniprot id: A0A0U3H7Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCCT transporter (TC 2.A.15) family.
messages: Membrane

446860:AS188 RS02920
gene id: 446860:AS188_RS02920
uniprot id: A0A0U2WQS0
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS00685
gene id: 446860:AS188_RS00685
uniprot id: A0A0U2NWB4
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS01760
gene id: 446860:AS188_RS01760
uniprot id: A0A0U3I5N4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

446860:AS188 RS00905
gene id: 446860:AS188_RS00905
uniprot id: A0A0U2XJK8
names: Similarity
messages: Belongs to the extradiol ring-cleavage dioxygenase family.

446860:AS188 RS00330
gene id: 446860:AS188_RS00330
uniprot id: A0A0U2XJ26
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS02210
gene id: 446860:AS188_RS02210
uniprot id: A0A0U3H7B0
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS14735
gene id: 446860:AS188_RS14735
uniprot id: A0A0U3I0R8
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS09665
gene id: 446860:AS188_RS09665
uniprot id: A0A0U3GIH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 2 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

446860:AS188 RS00780
gene id: 446860:AS188_RS00780
uniprot id: A0A0U3G5U5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

446860:AS188 RS11885
gene id: 446860:AS188_RS11885
uniprot id: A0A0U3HBN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

446860:AS188 RS02030
gene id: 446860:AS188_RS02030
uniprot id: A0A0U3HMA9
names: Similarity
messages: Belongs to the DSD1 family.

446860:AS188 RS15760
gene id: 446860:AS188_RS15760
uniprot id: A0A0U2WYM9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

446860:AS188 RS15270
gene id: 446860:AS188_RS15270
uniprot id: A0A0U3GKX5
names: Similarity
messages: Belongs to the CsoR family.

446860:AS188 RS11480
gene id: 446860:AS188_RS11480
uniprot id: A0A0U3HXP1
names: Function
names: Similarity
messages: Belongs to the SELO family.
messages: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).

446860:AS188 RS14035
gene id: 446860:AS188_RS14035
uniprot id: A0A0U3HHL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

446860:AS188 RS04220
gene id: 446860:AS188_RS04220
uniprot id: A0A0U2YU80
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

446860:AS188 RS06120
gene id: 446860:AS188_RS06120
uniprot id: A0A0U3H8Y7
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

446860:AS188 RS03230
gene id: 446860:AS188_RS03230
uniprot id: A0A0U3HCK8
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS02840
gene id: 446860:AS188_RS02840
uniprot id: A0A0U3HDI1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

446860:AS188 RS12240
gene id: 446860:AS188_RS12240
uniprot id: A0A0U3IAG9
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS12100
gene id: 446860:AS188_RS12100
uniprot id: A0A0U3HS79
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

446860:AS188 RS00085
gene id: 446860:AS188_RS00085
uniprot id: A0A0U3HCC3
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

446860:AS188 RS00305
gene id: 446860:AS188_RS00305
uniprot id: A0A0U3GEK3
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS08315
gene id: 446860:AS188_RS08315
uniprot id: A0A0U2P2K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446860:AS188 RS17425
gene id: 446860:AS188_RS17425
uniprot id: A0A0U2NYU5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS01345
gene id: 446860:AS188_RS01345
uniprot id: A0A0U3HUQ9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

446860:AS188 RS13835
gene id: 446860:AS188_RS13835
uniprot id: A0A0U3HCI8
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

446860:AS188 RS13030
gene id: 446860:AS188_RS13030
uniprot id: A0A0U2P103
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

446860:AS188 RS12725
gene id: 446860:AS188_RS12725
uniprot id: A0A0U3G6N8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

446860:AS188 RS00265
gene id: 446860:AS188_RS00265
uniprot id: A0A0U3HLH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

446860:AS188 RS00610
gene id: 446860:AS188_RS00610
uniprot id: A0A0U3HTE4
names: Function
messages: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.

446860:AS188 RS12885
gene id: 446860:AS188_RS12885
uniprot id: A0A0U2WVW8
names: Function
names: Similarity
messages: Belongs to the IMPDH/GMPR family. GuaB1 subfamily.
messages: Involved in the purine-salvage pathway. Catalyzes the NADPH-dependent conversion of GMP to IMP.

446860:AS188 RS01880
gene id: 446860:AS188_RS01880
uniprot id: A0A0U2XK02
names: Function
names: Similarity
messages: Belongs to the bacterial two-domain DSD family.
messages: Catalyzes the conversion of 3-dehydroshikimate to protocatechuate (3,4-dihydroxybenzoate), a common intermediate of quinate and shikimate degradation pathways.

446860:AS188 RS11120
gene id: 446860:AS188_RS11120
uniprot id: A0A0U2XPQ4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS14400
gene id: 446860:AS188_RS14400
uniprot id: A0A0U2WWM0
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

446860:AS188 RS12035
gene id: 446860:AS188_RS12035
uniprot id: A0A0U2P0N4
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS05465
gene id: 446860:AS188_RS05465
uniprot id: A0A0U3G855
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

446860:AS188 RS12160
gene id: 446860:AS188_RS12160
uniprot id: A0A0U3HYA3
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

446860:AS188 RS12170
gene id: 446860:AS188_RS12170
uniprot id: A0A0U2XQ87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

446860:AS188 RS08830
gene id: 446860:AS188_RS08830
uniprot id: A0A0U3G4N4
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

446860:AS188 RS09100
gene id: 446860:AS188_RS09100
uniprot id: A0A0U3HQU8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

446860:AS188 RS01270
gene id: 446860:AS188_RS01270
uniprot id: A0A0U2NWJ1
names: Function
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: Catalyzes the reversible reductive amination of pyruvate to L-alanine.

446860:AS188 RS02345
gene id: 446860:AS188_RS02345
uniprot id: A0A0U3I5Y0
names: Similarity
messages: Belongs to the UPF0065 (bug) family.

446860:AS188 RS00635
gene id: 446860:AS188_RS00635
uniprot id: A0A0U2WPH3
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

446860:AS188 RS13005
gene id: 446860:AS188_RS13005
uniprot id: A0A0U3HI30
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS05625
gene id: 446860:AS188_RS05625
uniprot id: A0A0U2WS46
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

446860:AS188 RS12910
gene id: 446860:AS188_RS12910
uniprot id: A0A0U3HI17
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS04295
gene id: 446860:AS188_RS04295
uniprot id: A0A0U3GG70
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS03705
gene id: 446860:AS188_RS03705
uniprot id: A0A0U3HVR0
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

446860:AS188 RS12215
gene id: 446860:AS188_RS12215
uniprot id: A0A0U3HZK6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

446860:AS188 RS09170
gene id: 446860:AS188_RS09170
uniprot id: A0A0U2XNS3
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

446860:AS188 RS05960
gene id: 446860:AS188_RS05960
uniprot id: A0A0U3GGX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446860:AS188 RS07080
gene id: 446860:AS188_RS07080
uniprot id: A0A0U2P2I4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics.
messages: Belongs to the MshB deacetylase family. Mca subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Monomer.

446860:AS188 RS11600
gene id: 446860:AS188_RS11600
uniprot id: A0A0U3HZB0
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

446860:AS188 RS14510
gene id: 446860:AS188_RS14510
uniprot id: A0A0U2WWQ0
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

446860:AS188 RS13495
gene id: 446860:AS188_RS13495
uniprot id: A0A0U3HYU0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the selenophosphate synthase 1 family. Class I subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Homodimer.
messages: Synthesizes selenophosphate from selenide and ATP.

446860:AS188 RS13850
gene id: 446860:AS188_RS13850
uniprot id: A0A0U3ICZ6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

446860:AS188 RS00110
gene id: 446860:AS188_RS00110
uniprot id: A0A0U3G5J2
names: Function
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

446860:AS188 RS11855
gene id: 446860:AS188_RS11855
uniprot id: A0A0U2YXY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

446860:AS188 RS00325
gene id: 446860:AS188_RS00325
uniprot id: A0A0U2YSE1
names: Similarity
messages: Belongs to the phosphohexose mutase family.

446860:AS188 RS10270
gene id: 446860:AS188_RS10270
uniprot id: A0A0U3HX76
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS06500
gene id: 446860:AS188_RS06500
uniprot id: A0A0U2XMC8
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS05360
gene id: 446860:AS188_RS05360
uniprot id: A0A0U3G2T7
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS10485
gene id: 446860:AS188_RS10485
uniprot id: A0A0U2YX82
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

446860:AS188 RS00830
gene id: 446860:AS188_RS00830
uniprot id: A0A0U3H6Q8
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS03265
gene id: 446860:AS188_RS03265
uniprot id: A0A0U3HU97
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS12355
gene id: 446860:AS188_RS12355
uniprot id: A0A0U3HY28
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.

446860:AS188 RS13820
gene id: 446860:AS188_RS13820
uniprot id: A0A0U3GDU6
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

446860:AS188 RS13970
gene id: 446860:AS188_RS13970
uniprot id: A0A0U3IB66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

446860:AS188 RS13360
gene id: 446860:AS188_RS13360
uniprot id: A0A0U2P140
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

446860:AS188 RS09620
gene id: 446860:AS188_RS09620
uniprot id: A0A0U3HYG1
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

446860:AS188 RS14495
gene id: 446860:AS188_RS14495
uniprot id: A0A0U3GNH6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.

446860:AS188 RS09480
gene id: 446860:AS188_RS09480
uniprot id: A0A0U3HWV9
names: Similarity
messages: Belongs to the IMPACT family.

446860:AS188 RS15045
gene id: 446860:AS188_RS15045
uniprot id: A0A0U3G7Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

446860:AS188 RS07895
gene id: 446860:AS188_RS07895
uniprot id: A0A0U3HXN1
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

446860:AS188 RS12530
gene id: 446860:AS188_RS12530
uniprot id: A0A0U3GJV9
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

446860:AS188 RS01995
gene id: 446860:AS188_RS01995
uniprot id: A0A0U3HHQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

446860:AS188 RS12975
gene id: 446860:AS188_RS12975
uniprot id: A0A0U3GMR8
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS16050
gene id: 446860:AS188_RS16050
uniprot id: A0A0U3HUY7
names: Similarity
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

446860:AS188 RS01840
gene id: 446860:AS188_RS01840
uniprot id: A0A0U3G6B8
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

446860:AS188 RS08105
gene id: 446860:AS188_RS08105
uniprot id: A0A0U3G4A3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

446860:AS188 RS13885
gene id: 446860:AS188_RS13885
uniprot id: A0A0U3IB49
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

446860:AS188 RS03510
gene id: 446860:AS188_RS03510
uniprot id: A0A0U3HN00
names: Similarity
messages: Belongs to the creatininase superfamily.

446860:AS188 RS11015
gene id: 446860:AS188_RS11015
uniprot id: A0A0U3HXU1
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

446860:AS188 RS04465
gene id: 446860:AS188_RS04465
uniprot id: A0A0U3G2E6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

446860:AS188 RS02950
gene id: 446860:AS188_RS02950
uniprot id: A0A0U3HCG1
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS09445
gene id: 446860:AS188_RS09445
uniprot id: A0A0U3I980
names: Similarity
names: Subunit
messages: Belongs to the pyruvate kinase family.
messages: Homotetramer.

446860:AS188 RS09990
gene id: 446860:AS188_RS09990
uniprot id: A0A0U3HXD8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS05585
gene id: 446860:AS188_RS05585
uniprot id: A0A0U2NYA2
names: Similarity
names: Subunit
messages: Belongs to the multicopper oxidase family.
messages: Homotrimer.

446860:AS188 RS10605
gene id: 446860:AS188_RS10605
uniprot id: A0A0U3HRI5
names: Similarity
messages: Belongs to the peptidase S8 family.

446860:AS188 RS07340
gene id: 446860:AS188_RS07340
uniprot id: A0A0U3HEJ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

446860:AS188 RS14575
gene id: 446860:AS188_RS14575
uniprot id: A0A0U3HZ95
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS14265
gene id: 446860:AS188_RS14265
uniprot id: A0A0U3HYY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

446860:AS188 RS17520
gene id: 446860:AS188_RS17520
uniprot id: A0A0U2XPC9
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

446860:AS188 RS12410
gene id: 446860:AS188_RS12410
uniprot id: A0A0U3HGX7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

446860:AS188 RS05835
gene id: 446860:AS188_RS05835
uniprot id: A0A0U3HWS2
names: Similarity
messages: Belongs to the universal stress protein A family.

446860:AS188 RS12925
gene id: 446860:AS188_RS12925
uniprot id: A0A0U3GBK8
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

446860:AS188 RS10780
gene id: 446860:AS188_RS10780
uniprot id: A0A0U3HRL6
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
messages: Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
messages: The reaction mechanism probably proceeds via the activation of Pup by phosphorylation of its C-terminal glutamate, which is then subject to nucleophilic attack by the substrate lysine, resulting in an isopeptide bond and the release of phosphate as a good leaving group.

446860:AS188 RS02365
gene id: 446860:AS188_RS02365
uniprot id: A0A0U3HTY3
names: Subcellular Location Annotation
messages: Cytoplasm

446860:AS188 RS09350
gene id: 446860:AS188_RS09350
uniprot id: A0A0U2NZN5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

446860:AS188 RS12270
gene id: 446860:AS188_RS12270
uniprot id: A0A0U2YY49
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

446860:AS188 RS09390
gene id: 446860:AS188_RS09390
uniprot id: A0A0U3GL33
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

446860:AS188 RS17420
gene id: 446860:AS188_RS17420
uniprot id: A0A0U3I008
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

446860:AS188 RS11960
gene id: 446860:AS188_RS11960
uniprot id: A0A0U2XQ43
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

446860:AS188 RS15630
gene id: 446860:AS188_RS15630
uniprot id: A0A0U3GCW3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

446860:AS188 RS11020
gene id: 446860:AS188_RS11020
uniprot id: A0A0U2YXH2
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

446860:AS188 RS06105
gene id: 446860:AS188_RS06105
uniprot id: A0A0U3GJ79
names: Similarity
messages: Belongs to the Nth/MutY family.

446860:AS188 RS11180
gene id: 446860:AS188_RS11180
uniprot id: A0A0U3I9Y5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

446860:AS188 RS01055
gene id: 446860:AS188_RS01055
uniprot id: A0A0U2NWG2
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

446860:AS188 RS06335
gene id: 446860:AS188_RS06335
uniprot id: A0A0U3HPF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

446860:AS188 RS12065
gene id: 446860:AS188_RS12065
uniprot id: A0A0U3HY88
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

446860:AS188 RS01815
gene id: 446860:AS188_RS01815
uniprot id: A0A0U3HM77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Cell inner membrane
messages: Membrane

446860:AS188 RS02285
gene id: 446860:AS188_RS02285
uniprot id: A0A0U2XK78
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

446860:AS188 RS13625
gene id: 446860:AS188_RS13625
uniprot id: A0A0U3HUJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

446860:AS188 RS09765
gene id: 446860:AS188_RS09765
uniprot id: A0A0U3GIJ4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS05720
gene id: 446860:AS188_RS05720
uniprot id: A0A0U2WS58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 87 family.
messages: Membrane

446860:AS188 RS02600
gene id: 446860:AS188_RS02600
uniprot id: A0A0U3H7G9
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS06550
gene id: 446860:AS188_RS06550
uniprot id: A0A0U3I7Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

446860:AS188 RS12150
gene id: 446860:AS188_RS12150
uniprot id: A0A0U3GJN1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

446860:AS188 RS10925
gene id: 446860:AS188_RS10925
uniprot id: A0A0U3HXS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with subunits I, II and III to form cytochrome c oxidase.
messages: Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
messages: Cell membrane
messages: Membrane
messages: Part of cytochrome c oxidase, its function is unknown.

446860:AS188 RS13135
gene id: 446860:AS188_RS13135
uniprot id: A0A0U3IAU7
names: Similarity
messages: Belongs to the PspA/IM30 family.

446860:AS188 RS13000
gene id: 446860:AS188_RS13000
uniprot id: A0A0U3HZY5
names: Similarity
messages: Belongs to the ABC transporter superfamily.

446860:AS188 RS06455
gene id: 446860:AS188_RS06455
uniprot id: A0A0U3G3C2
names: Function
names: Similarity
messages: Belongs to the trehalose phosphatase family.
messages: Removes the phosphate from trehalose 6-phosphate to produce free trehalose.

446860:AS188 RS12325
gene id: 446860:AS188_RS12325
uniprot id: A0A0U3G6G7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

446860:AS188 RS17730
gene id: 446860:AS188_RS17730
uniprot id: A0A0U2XR41
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

446860:AS188 RS02300
gene id: 446860:AS188_RS02300
uniprot id: A0A0U3H7C5
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

446860:AS188 RS11300
gene id: 446860:AS188_RS11300
uniprot id: A0A0U3HXY5
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

446860:AS188 RS06430
gene id: 446860:AS188_RS06430
uniprot id: A0A0U3H925
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

446860:AS188 RS04045
gene id: 446860:AS188_RS04045
uniprot id: A0A0U2YU46
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS13385
gene id: 446860:AS188_RS13385
uniprot id: A0A0U3HYS9
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

446860:AS188 RS07635
gene id: 446860:AS188_RS07635
uniprot id: A0A0U3G980
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial sugar transferase family.
messages: Membrane

446860:AS188 RS06585
gene id: 446860:AS188_RS06585
uniprot id: A0A0U2XMG0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cell surface
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
messages: capsule
messages: cell wall

446860:AS188 RS09250
gene id: 446860:AS188_RS09250
uniprot id: A0A0U2YWQ0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

446860:AS188 RS09255
gene id: 446860:AS188_RS09255
uniprot id: A0A0U2XNT8
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

446860:AS188 RS01110
gene id: 446860:AS188_RS01110
uniprot id: A0A0U2WPW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.
messages: Membrane

446860:AS188 RS08765
gene id: 446860:AS188_RS08765
uniprot id: A0A0U3GI59
names: Function
names: Similarity
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
messages: Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.

446860:AS188 RS04795
gene id: 446860:AS188_RS04795
uniprot id: A0A0U2YUH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

446860:AS188 RS00495
gene id: 446860:AS188_RS00495
uniprot id: A0A0U2NW92
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS09025
gene id: 446860:AS188_RS09025
uniprot id: A0A0U3HFD1
names: Similarity
messages: Belongs to the YggT family.

446860:AS188 RS14480
gene id: 446860:AS188_RS14480
uniprot id: A0A0U3HJD0
names: Function
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
messages: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).

446860:AS188 RS12400
gene id: 446860:AS188_RS12400
uniprot id: A0A0U3HZP4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS09530
gene id: 446860:AS188_RS09530
uniprot id: A0A0U3HFM1
names: Similarity
messages: Belongs to the fructosamine kinase family.

446860:AS188 RS09385
gene id: 446860:AS188_RS09385
uniprot id: A0A0U2XNX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

446860:AS188 RS14050
gene id: 446860:AS188_RS14050
uniprot id: A0A0U3IB82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

446860:AS188 RS04605
gene id: 446860:AS188_RS04605
uniprot id: A0A0U2XLC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

446860:AS188 RS05640
gene id: 446860:AS188_RS05640
uniprot id: A0A0U3HWP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: Cell membrane
messages: Membrane

446860:AS188 RS05540
gene id: 446860:AS188_RS05540
uniprot id: A0A0U3HP12
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS04715
gene id: 446860:AS188_RS04715
uniprot id: A0A0U3H8E6
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS06930
gene id: 446860:AS188_RS06930
uniprot id: A0A0U3I848
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

446860:AS188 RS15545
gene id: 446860:AS188_RS15545
uniprot id: A0A0U3G7Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446860:AS188 RS00980
gene id: 446860:AS188_RS00980
uniprot id: A0A0U3GEU6
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two nickel ions.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

446860:AS188 RS04950
gene id: 446860:AS188_RS04950
uniprot id: A0A0U3G2N0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
messages: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
messages: Homotetramer.

446860:AS188 RS11920
gene id: 446860:AS188_RS11920
uniprot id: A0A0U3G6A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Membrane

446860:AS188 RS02865
gene id: 446860:AS188_RS02865
uniprot id: A0A0U3G6T5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

446860:AS188 RS00670
gene id: 446860:AS188_RS00670
uniprot id: A0A0U3G0H1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

446860:AS188 RS08415
gene id: 446860:AS188_RS08415
uniprot id: A0A0U3HF21
names: Similarity
messages: Belongs to the peptidase M16 family.

446860:AS188 RS15515
gene id: 446860:AS188_RS15515
uniprot id: A0A0U3HTJ3
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS09605
gene id: 446860:AS188_RS09605
uniprot id: A0A0U3HAJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

446860:AS188 RS14890
gene id: 446860:AS188_RS14890
uniprot id: A0A0U2YZB9
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS00340
gene id: 446860:AS188_RS00340
uniprot id: A0A0U2WPA3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Monomer.

446860:AS188 RS12235
gene id: 446860:AS188_RS12235
uniprot id: A0A0U3GB94
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

446860:AS188 RS14145
gene id: 446860:AS188_RS14145
uniprot id: A0A0U2P1E9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

446860:AS188 RS00785
gene id: 446860:AS188_RS00785
uniprot id: A0A0U3I542
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS13880
gene id: 446860:AS188_RS13880
uniprot id: A0A0U3GM08
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

446860:AS188 RS01035
gene id: 446860:AS188_RS01035
uniprot id: A0A0U3HBM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

446860:AS188 RS15790
gene id: 446860:AS188_RS15790
uniprot id: A0A0U3G9A4
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS10295
gene id: 446860:AS188_RS10295
uniprot id: A0A0U3GLG4
names: Similarity
names: Subunit
messages: Belongs to the muconolactone Delta-isomerase family.
messages: Homodecamer.

446860:AS188 RS07610
gene id: 446860:AS188_RS07610
uniprot id: A0A0U3HEP2
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS08405
gene id: 446860:AS188_RS08405
uniprot id: A0A0U3HXW3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

446860:AS188 RS13150
gene id: 446860:AS188_RS13150
uniprot id: A0A0U3GK51
names: Similarity
messages: Belongs to the peptidase S16 family.

446860:AS188 RS13335
gene id: 446860:AS188_RS13335
uniprot id: A0A0U3HHB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

446860:AS188 RS08370
gene id: 446860:AS188_RS08370
uniprot id: A0A0U3GKH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

446860:AS188 RS02360
gene id: 446860:AS188_RS02360
uniprot id: A0A0U3G8B2
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS14785
gene id: 446860:AS188_RS14785
uniprot id: A0A0U3HZC6
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS10200
gene id: 446860:AS188_RS10200
uniprot id: A0A0U3HAU9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

446860:AS188 RS12230
gene id: 446860:AS188_RS12230
uniprot id: A0A0U3G6F0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A probable RNA-binding protein.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm

446860:AS188 RS08565
gene id: 446860:AS188_RS08565
uniprot id: A0A0U3HWV7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

446860:AS188 RS00225
gene id: 446860:AS188_RS00225
uniprot id: A0A0U3HT66
names: Similarity
messages: Belongs to the cytochrome P450 family.

446860:AS188 RS06945
gene id: 446860:AS188_RS06945
uniprot id: A0A0U3HVX8
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS05675
gene id: 446860:AS188_RS05675
uniprot id: A0A0U3GGS5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

446860:AS188 RS04760
gene id: 446860:AS188_RS04760
uniprot id: A0A0U3G7V0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS15505
gene id: 446860:AS188_RS15505
uniprot id: A0A0U2WX73
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

446860:AS188 RS13205
gene id: 446860:AS188_RS13205
uniprot id: A0A0U3HC83
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

446860:AS188 RS14045
gene id: 446860:AS188_RS14045
uniprot id: A0A0U3GC49
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

446860:AS188 RS14075
gene id: 446860:AS188_RS14075
uniprot id: A0A0U2YYZ5
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

446860:AS188 RS01560
gene id: 446860:AS188_RS01560
uniprot id: A0A0U3G0W4
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

446860:AS188 RS08770
gene id: 446860:AS188_RS08770
uniprot id: A0A0U3HWM0
names: Similarity
messages: Belongs to the PrpD family.

446860:AS188 RS12790
gene id: 446860:AS188_RS12790
uniprot id: A0A0U2WVV2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS13960
gene id: 446860:AS188_RS13960
uniprot id: A0A0U3G792
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

446860:AS188 RS03125
gene id: 446860:AS188_RS03125
uniprot id: A0A0U3HMU0
names: Similarity
messages: Belongs to the band 7/mec-2 family.

446860:AS188 RS12110
gene id: 446860:AS188_RS12110
uniprot id: A0A0U3HHQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

446860:AS188 RS12515
gene id: 446860:AS188_RS12515
uniprot id: A0A0U3GBD0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

446860:AS188 RS05595
gene id: 446860:AS188_RS05595
uniprot id: A0A0U3HVB9
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

446860:AS188 RS05150
gene id: 446860:AS188_RS05150
uniprot id: A0A0U3HDI3
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

446860:AS188 RS05615
gene id: 446860:AS188_RS05615
uniprot id: A0A0U2XLU9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

446860:AS188 RS14880
gene id: 446860:AS188_RS14880
uniprot id: A0A0U2Z0U6
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

446860:AS188 RS00365
gene id: 446860:AS188_RS00365
uniprot id: A0A0U3HCH4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS05635
gene id: 446860:AS188_RS05635
uniprot id: A0A0U3HP37
names: Similarity
messages: Belongs to the cytochrome P450 family.

446860:AS188 RS06075
gene id: 446860:AS188_RS06075
uniprot id: A0A0U3GGY9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

446860:AS188 RS13845
gene id: 446860:AS188_RS13845
uniprot id: A0A0U3I0A4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

446860:AS188 RS09745
gene id: 446860:AS188_RS09745
uniprot id: A0A0U3GA50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

446860:AS188 RS15325
gene id: 446860:AS188_RS15325
uniprot id: A0A0U3I107
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

446860:AS188 RS11675
gene id: 446860:AS188_RS11675
uniprot id: A0A0U3HBK6
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS13715
gene id: 446860:AS188_RS13715
uniprot id: A0A0U3HYW4
names: Similarity
messages: Belongs to the IMPDH/GMPR family.

446860:AS188 RS15635
gene id: 446860:AS188_RS15635
uniprot id: A0A0U3IBY7
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

446860:AS188 RS08465
gene id: 446860:AS188_RS08465
uniprot id: A0A0U3HDX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

446860:AS188 RS11160
gene id: 446860:AS188_RS11160
uniprot id: A0A0U3HGD1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS01220
gene id: 446860:AS188_RS01220
uniprot id: A0A0U3HIF7
names: Similarity
messages: Belongs to the peptidase M13 family.

446860:AS188 RS04640
gene id: 446860:AS188_RS04640
uniprot id: A0A0U3HDA9
names: Similarity
messages: Belongs to the type IB topoisomerase family.

446860:AS188 RS10700
gene id: 446860:AS188_RS10700
uniprot id: A0A0U3HH41
names: Similarity
messages: Belongs to the manganese catalase family.

446860:AS188 RS13705
gene id: 446860:AS188_RS13705
uniprot id: A0A0U3GKC5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

446860:AS188 RS03055
gene id: 446860:AS188_RS03055
uniprot id: A0A0U3I6E4
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

446860:AS188 RS08535
gene id: 446860:AS188_RS08535
uniprot id: A0A0U3G9L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

446860:AS188 RS12865
gene id: 446860:AS188_RS12865
uniprot id: A0A0U2YYE5
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

446860:AS188 RS12275
gene id: 446860:AS188_RS12275
uniprot id: A0A0U2XQC0
names: Similarity
messages: Belongs to the P(II) protein family.

446860:AS188 RS12030
gene id: 446860:AS188_RS12030
uniprot id: A0A0U3IAD5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

446860:AS188 RS12180
gene id: 446860:AS188_RS12180
uniprot id: A0A0U3GDQ1
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

446860:AS188 RS00985
gene id: 446860:AS188_RS00985
uniprot id: A0A0U3HTB8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

446860:AS188 RS00630
gene id: 446860:AS188_RS00630
uniprot id: A0A0U3GGK0
names: Similarity
messages: Belongs to the DnaX/STICHEL family.

446860:AS188 RS07440
gene id: 446860:AS188_RS07440
uniprot id: A0A0U3I8C8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

446860:AS188 RS00745
gene id: 446860:AS188_RS00745
uniprot id: A0A0U3HLR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein SsuA/TauA family.
messages: Periplasm

446860:AS188 RS07645
gene id: 446860:AS188_RS07645
uniprot id: A0A0U2NZ07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

446860:AS188 RS06980
gene id: 446860:AS188_RS06980
uniprot id: A0A0U2WSV3
names: Similarity
messages: Belongs to the BMP lipoprotein family.

446860:AS188 RS15550
gene id: 446860:AS188_RS15550
uniprot id: A0A0U3GCU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446860:AS188 RS02700
gene id: 446860:AS188_RS02700
uniprot id: A0A0U2XKE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

446860:AS188 RS00965
gene id: 446860:AS188_RS00965
uniprot id: A0A0U3G5W8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

446860:AS188 RS00580
gene id: 446860:AS188_RS00580
uniprot id: A0A0U3G5S4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS14025
gene id: 446860:AS188_RS14025
uniprot id: A0A0U3I0E5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

446860:AS188 RS11345
gene id: 446860:AS188_RS11345
uniprot id: A0A0U3HHD9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MurCDEF family. MurT subfamily.
messages: Forms a heterodimer with GatD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.

446860:AS188 RS12875
gene id: 446860:AS188_RS12875
uniprot id: A0A0U2XQL7
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS01315
gene id: 446860:AS188_RS01315
uniprot id: A0A0U2YSV7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

446860:AS188 RS08610
gene id: 446860:AS188_RS08610
uniprot id: A0A0U3HF77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

446860:AS188 RS01410
gene id: 446860:AS188_RS01410
uniprot id: A0A0U2YSW4
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

446860:AS188 RS12405
gene id: 446860:AS188_RS12405
uniprot id: A0A0U3HHV0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

446860:AS188 RS03445
gene id: 446860:AS188_RS03445
uniprot id: A0A0U3G1U9
names: Similarity
messages: Belongs to the asparaginase 1 family.

446860:AS188 RS08510
gene id: 446860:AS188_RS08510
uniprot id: A0A0U3HQJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

446860:AS188 RS04705
gene id: 446860:AS188_RS04705
uniprot id: A0A0U2WRQ4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

446860:AS188 RS09105
gene id: 446860:AS188_RS09105
uniprot id: A0A0U3HY91
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

446860:AS188 RS12385
gene id: 446860:AS188_RS12385
uniprot id: A0A0U3HBV7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

446860:AS188 RS12450
gene id: 446860:AS188_RS12450
uniprot id: A0A0U2YY78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

446860:AS188 RS02235
gene id: 446860:AS188_RS02235
uniprot id: A0A0U3HC59
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

446860:AS188 RS05155
gene id: 446860:AS188_RS05155
uniprot id: A0A0U3G2Q8
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

446860:AS188 RS00360
gene id: 446860:AS188_RS00360
uniprot id: A0A0U3HU94
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

446860:AS188 RS12000
gene id: 446860:AS188_RS12000
uniprot id: A0A0U3HZH9
names: Similarity
messages: Belongs to the LacAB/RpiB family.

446860:AS188 RS13825
gene id: 446860:AS188_RS13825
uniprot id: A0A0U3GN49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Cytoplasm

446860:AS188 RS07200
gene id: 446860:AS188_RS07200
uniprot id: A0A0U2XSJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Belongs to the precorrin methyltransferase family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

446860:AS188 RS06640
gene id: 446860:AS188_RS06640
uniprot id: A0A0U3G8S8
names: Similarity
messages: Belongs to the peptidase C40 family.

446860:AS188 RS03425
gene id: 446860:AS188_RS03425
uniprot id: A0A0U3HVL5
names: Similarity
messages: Belongs to the FGGY kinase family.

446860:AS188 RS13965
gene id: 446860:AS188_RS13965
uniprot id: A0A0U3GC36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

446860:AS188 RS06330
gene id: 446860:AS188_RS06330
uniprot id: A0A0U3H912
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

446860:AS188 RS09490
gene id: 446860:AS188_RS09490
uniprot id: A0A0U2YWT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCCT transporter (TC 2.A.15) family.
messages: Membrane

446860:AS188 RS08445
gene id: 446860:AS188_RS08445
uniprot id: A0A0U3I8S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

446860:AS188 RS14160
gene id: 446860:AS188_RS14160
uniprot id: A0A0U3HZ41
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

446860:AS188 RS00990
gene id: 446860:AS188_RS00990
uniprot id: A0A0U3HTJ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

446860:AS188 RS03365
gene id: 446860:AS188_RS03365
uniprot id: A0A0U2NXE9
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.

446860:AS188 RS05725
gene id: 446860:AS188_RS05725
uniprot id: A0A0U3H8T8
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS10880
gene id: 446860:AS188_RS10880
uniprot id: A0A0U3G5R1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS10985
gene id: 446860:AS188_RS10985
uniprot id: A0A0U3G5T9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

446860:AS188 RS01030
gene id: 446860:AS188_RS01030
uniprot id: A0A0U3HCR5
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS10565
gene id: 446860:AS188_RS10565
uniprot id: A0A0U3GIW8
names: Similarity
messages: Belongs to the 6-phosphogluconate dehydrogenase family.

446860:AS188 RS10385
gene id: 446860:AS188_RS10385
uniprot id: A0A0U2XPB1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS03680
gene id: 446860:AS188_RS03680
uniprot id: A0A0U3GI15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

446860:AS188 RS02335
gene id: 446860:AS188_RS02335
uniprot id: A0A0U3G191
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS06380
gene id: 446860:AS188_RS06380
uniprot id: A0A0U3GH35
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

446860:AS188 RS09660
gene id: 446860:AS188_RS09660
uniprot id: A0A0U2NZS7
names: Similarity
messages: Belongs to the GPI family.

446860:AS188 RS00550
gene id: 446860:AS188_RS00550
uniprot id: A0A0U3HLM5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IPP isomerase type 1 family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Cytoplasm

446860:AS188 RS09675
gene id: 446860:AS188_RS09675
uniprot id: A0A0U2WY35
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Membrane

446860:AS188 RS07235
gene id: 446860:AS188_RS07235
uniprot id: A0A0U3GPJ6
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

446860:AS188 RS09165
gene id: 446860:AS188_RS09165
uniprot id: A0A0U2YWN6
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

446860:AS188 RS06545
gene id: 446860:AS188_RS06545
uniprot id: A0A0U3G8R2
names: Similarity
messages: Belongs to the FemABX family.

446860:AS188 RS14555
gene id: 446860:AS188_RS14555
uniprot id: A0A0U2P1J5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

446860:AS188 RS12080
gene id: 446860:AS188_RS12080
uniprot id: A0A0U3GMD5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

446860:AS188 RS04240
gene id: 446860:AS188_RS04240
uniprot id: A0A0U3H865
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS08520
gene id: 446860:AS188_RS08520
uniprot id: A0A0U3HG53
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

446860:AS188 RS06130
gene id: 446860:AS188_RS06130
uniprot id: A0A0U3HWW7
names: Similarity
messages: Belongs to the PstS family.

446860:AS188 RS06965
gene id: 446860:AS188_RS06965
uniprot id: A0A0U2XMP7
names: Similarity
messages: Belongs to the cytochrome b560 family.

446860:AS188 RS04485
gene id: 446860:AS188_RS04485
uniprot id: A0A0U3GG99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

446860:AS188 RS13585
gene id: 446860:AS188_RS13585
uniprot id: A0A0U2WYF0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

446860:AS188 RS13675
gene id: 446860:AS188_RS13675
uniprot id: A0A0U3HHF7
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

446860:AS188 RS08435
gene id: 446860:AS188_RS08435
uniprot id: A0A0U3G4F6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

446860:AS188 RS00800
gene id: 446860:AS188_RS00800
uniprot id: A0A0U3HT96
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

446860:AS188 RS10575
gene id: 446860:AS188_RS10575
uniprot id: A0A0U3HXL7
names: Similarity
messages: Belongs to the AHA1 family.

446860:AS188 RS07140
gene id: 446860:AS188_RS07140
uniprot id: A0A0U3G905
names: Similarity
messages: Belongs to the FemABX family.

446860:AS188 RS02195
gene id: 446860:AS188_RS02195
uniprot id: A0A0U2XK62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

446860:AS188 RS04620
gene id: 446860:AS188_RS04620
uniprot id: A0A0U3H8C9
names: Similarity
messages: Belongs to the group II decarboxylase family.

446860:AS188 RS01230
gene id: 446860:AS188_RS01230
uniprot id: A0A0U3HCT5
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

446860:AS188 RS10805
gene id: 446860:AS188_RS10805
uniprot id: A0A0U3GAK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

446860:AS188 RS13930
gene id: 446860:AS188_RS13930
uniprot id: A0A0U2WWC5
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

446860:AS188 RS10775
gene id: 446860:AS188_RS10775
uniprot id: A0A0U3HB46
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic ubiquitin-like protein family.
messages: Is modified by deamidation of its C-terminal glutamine to glutamate by the deamidase Dop, a prerequisite to the subsequent pupylation process.
messages: Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.
messages: Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half. There is one Pup binding site per ARC hexamer ring.
messages: The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome.

446860:AS188 RS00035
gene id: 446860:AS188_RS00035
uniprot id: A0A0U3GEG7
names: Similarity
names: Subunit
messages: Belongs to the muconolactone Delta-isomerase family.
messages: Homodecamer.

446860:AS188 RS07955
gene id: 446860:AS188_RS07955
uniprot id: A0A0U3HWB8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine.

446860:AS188 RS08750
gene id: 446860:AS188_RS08750
uniprot id: A0A0U3ICL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

446860:AS188 RS12265
gene id: 446860:AS188_RS12265
uniprot id: A0A0U3HYC5
names: Similarity
messages: Belongs to the Nudix hydrolase family.

446860:AS188 RS02215
gene id: 446860:AS188_RS02215
uniprot id: A0A0U3HME5
names: Similarity
messages: Belongs to the HIBADH-related family.

446860:AS188 RS00845
gene id: 446860:AS188_RS00845
uniprot id: A0A0U3HUI3
names: Similarity
messages: Belongs to the TPP enzyme family.

446860:AS188 RS01785
gene id: 446860:AS188_RS01785
uniprot id: A0A0U2YT47
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

446860:AS188 RS15615
gene id: 446860:AS188_RS15615
uniprot id: A0A0U3HJ77
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

446860:AS188 RS08820
gene id: 446860:AS188_RS08820
uniprot id: A0A0U3HFA3
names: Similarity
messages: Belongs to the prephenate/arogenate dehydrogenase family.

446860:AS188 RS01215
gene id: 446860:AS188_RS01215
uniprot id: A0A0U3HLY3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

446860:AS188 RS14015
gene id: 446860:AS188_RS14015
uniprot id: A0A0U3HCM8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

446860:AS188 RS12805
gene id: 446860:AS188_RS12805
uniprot id: A0A0U3ICW3
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

446860:AS188 RS08270
gene id: 446860:AS188_RS08270
uniprot id: A0A0U2WTL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

446860:AS188 RS12345
gene id: 446860:AS188_RS12345
uniprot id: A0A0U2P0S1
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

446860:AS188 RS03450
gene id: 446860:AS188_RS03450
uniprot id: A0A0U3G748
names: Similarity
messages: Belongs to the YciI family.

446860:AS188 RS11340
gene id: 446860:AS188_RS11340
uniprot id: A0A0U3HZ70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobB/CobQ family. GatD subfamily.
messages: Forms a heterodimer with MurT.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.

446860:AS188 RS03070
gene id: 446860:AS188_RS03070
uniprot id: A0A0U3GFP2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0).

446860:AS188 RS14515
gene id: 446860:AS188_RS14515
uniprot id: A0A0U3HCU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Catalyzes the sodium-dependent uptake of extracellular L-proline.
messages: Cell membrane
messages: Membrane

446860:AS188 RS13120
gene id: 446860:AS188_RS13120
uniprot id: A0A0U3HH87
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS10790
gene id: 446860:AS188_RS10790
uniprot id: A0A0U3HH56
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

446860:AS188 RS12285
gene id: 446860:AS188_RS12285
uniprot id: A0A0U3GMG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

446860:AS188 RS14170
gene id: 446860:AS188_RS14170
uniprot id: A0A0U2XR83
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

446860:AS188 RS12175
gene id: 446860:AS188_RS12175
uniprot id: A0A0U3GMF0
names: Similarity
messages: Belongs to the DprA/Smf family.

446860:AS188 RS05245
gene id: 446860:AS188_RS05245
uniprot id: A0A0U3HEL3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

446860:AS188 RS10955
gene id: 446860:AS188_RS10955
uniprot id: A0A0U3HB75
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

446860:AS188 RS04385
gene id: 446860:AS188_RS04385
uniprot id: A0A0U3GG84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

446860:AS188 RS04105
gene id: 446860:AS188_RS04105
uniprot id: A0A0U2NXQ0
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

446860:AS188 RS02005
gene id: 446860:AS188_RS02005
uniprot id: A0A0U3GH74
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS04690
gene id: 446860:AS188_RS04690
uniprot id: A0A0U2YUF6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

446860:AS188 RS13350
gene id: 446860:AS188_RS13350
uniprot id: A0A0U3GBS5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.
messages: Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
messages: Cytoplasm
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS09130
gene id: 446860:AS188_RS09130
uniprot id: A0A0U3G9V6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

446860:AS188 RS12945
gene id: 446860:AS188_RS12945
uniprot id: A0A0U3HYD2
names: Similarity
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

446860:AS188 RS00675
gene id: 446860:AS188_RS00675
uniprot id: A0A0U3G5T7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

446860:AS188 RS10810
gene id: 446860:AS188_RS10810
uniprot id: A0A0U3I9S2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

446860:AS188 RS02110
gene id: 446860:AS188_RS02110
uniprot id: A0A0U2XK46
names: Function
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: Catalyzes the reversible reductive amination of pyruvate to L-alanine.

446860:AS188 RS10890
gene id: 446860:AS188_RS10890
uniprot id: A0A0U3GAL7
names: Caution
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Binds 2 heme c groups covalently per subunit.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The cytochrome bc1 complex is composed of a cytochrome b (QcrB), the Rieske iron-sulfur protein (QcrA) and a diheme cytochrome c (QcrC) subunit.

446860:AS188 RS14900
gene id: 446860:AS188_RS14900
uniprot id: A0A0U2XRH6
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS00695
gene id: 446860:AS188_RS00695
uniprot id: A0A0U3HT76
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

446860:AS188 RS08410
gene id: 446860:AS188_RS08410
uniprot id: A0A0U3HG14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

446860:AS188 RS06870
gene id: 446860:AS188_RS06870
uniprot id: A0A0U2XML3
names: Cofactor
names: Similarity
messages: Belongs to the monomeric-type IDH family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

446860:AS188 RS08980
gene id: 446860:AS188_RS08980
uniprot id: A0A0U3HX12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

446860:AS188 RS06435
gene id: 446860:AS188_RS06435
uniprot id: A0A0U3HPH3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.
messages: Belongs to the fatty acyl-CoA reductase family.

446860:AS188 RS13340
gene id: 446860:AS188_RS13340
uniprot id: A0A0U3G700
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

446860:AS188 RS02405
gene id: 446860:AS188_RS02405
uniprot id: A0A0U3HMI0
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

446860:AS188 RS04445
gene id: 446860:AS188_RS04445
uniprot id: A0A0U3HE92
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

446860:AS188 RS14570
gene id: 446860:AS188_RS14570
uniprot id: A0A0U3HZ30
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS04900
gene id: 446860:AS188_RS04900
uniprot id: A0A0U2YUI8
names: Similarity
messages: Belongs to the HIBADH-related family.

446860:AS188 RS02805
gene id: 446860:AS188_RS02805
uniprot id: A0A0U2WQQ9
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

446860:AS188 RS08680
gene id: 446860:AS188_RS08680
uniprot id: A0A0U3GKN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

446860:AS188 RS06690
gene id: 446860:AS188_RS06690
uniprot id: A0A0U3GJG3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

446860:AS188 RS12710
gene id: 446860:AS188_RS12710
uniprot id: A0A0U3HZU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

446860:AS188 RS08650
gene id: 446860:AS188_RS08650
uniprot id: A0A0U3HWK8
names: Similarity
messages: Belongs to the catalase family.

446860:AS188 RS03000
gene id: 446860:AS188_RS03000
uniprot id: A0A0U2XKI8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

446860:AS188 RS12630
gene id: 446860:AS188_RS12630
uniprot id: A0A0U2P0V7
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

446860:AS188 RS14520
gene id: 446860:AS188_RS14520
uniprot id: A0A0U3HT44
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS01525
gene id: 446860:AS188_RS01525
uniprot id: A0A0U3GGY2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
messages: Cytoplasm

446860:AS188 RS11255
gene id: 446860:AS188_RS11255
uniprot id: A0A0U3HZ60
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

446860:AS188 RS15250
gene id: 446860:AS188_RS15250
uniprot id: A0A0U3I0M1
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS05670
gene id: 446860:AS188_RS05670
uniprot id: A0A0U2NYB3
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS05840
gene id: 446860:AS188_RS05840
uniprot id: A0A0U3HEV7
names: Similarity
messages: Belongs to the universal stress protein A family.

446860:AS188 RS09040
gene id: 446860:AS188_RS09040
uniprot id: A0A0U3I935
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

446860:AS188 RS06515
gene id: 446860:AS188_RS06515
uniprot id: A0A0U3H936
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

446860:AS188 RS07055
gene id: 446860:AS188_RS07055
uniprot id: A0A0U3GHE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

446860:AS188 RS01400
gene id: 446860:AS188_RS01400
uniprot id: A0A0U3HTH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

446860:AS188 RS08990
gene id: 446860:AS188_RS08990
uniprot id: A0A0U2XNP6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS03560
gene id: 446860:AS188_RS03560
uniprot id: A0A0U3HUL0
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

446860:AS188 RS06135
gene id: 446860:AS188_RS06135
uniprot id: A0A0U3HF13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

446860:AS188 RS11935
gene id: 446860:AS188_RS11935
uniprot id: A0A0U2P0M3
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

446860:AS188 RS09550
gene id: 446860:AS188_RS09550
uniprot id: A0A0U3I996
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

446860:AS188 RS07790
gene id: 446860:AS188_RS07790
uniprot id: A0A0U3HQ63
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

446860:AS188 RS02835
gene id: 446860:AS188_RS02835
uniprot id: A0A0U3HVA9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

446860:AS188 RS07760
gene id: 446860:AS188_RS07760
uniprot id: A0A0U2YVW0
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

446860:AS188 RS05905
gene id: 446860:AS188_RS05905
uniprot id: A0A0U2WS88
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

446860:AS188 RS01615
gene id: 446860:AS188_RS01615
uniprot id: A0A0U3H723
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 1 family.
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

446860:AS188 RS11305
gene id: 446860:AS188_RS11305
uniprot id: A0A0U2YXM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

446860:AS188 RS15785
gene id: 446860:AS188_RS15785
uniprot id: A0A0U3HJG3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

446860:AS188 RS03185
gene id: 446860:AS188_RS03185
uniprot id: A0A0U2YTQ8
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS08110
gene id: 446860:AS188_RS08110
uniprot id: A0A0U3G9F4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

446860:AS188 RS06150
gene id: 446860:AS188_RS06150
uniprot id: A0A0U3G8K5
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS08055
gene id: 446860:AS188_RS08055
uniprot id: A0A0U2XN81
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Belongs to the acyl-CoA oxidase family.

446860:AS188 RS12335
gene id: 446860:AS188_RS12335
uniprot id: A0A0U3GBA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

446860:AS188 RS06015
gene id: 446860:AS188_RS06015
uniprot id: A0A0U3HPA1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

446860:AS188 RS05380
gene id: 446860:AS188_RS05380
uniprot id: A0A0U3GGP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class II aldolase/RraA-like family.
messages: Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
messages: Homotrimer.

446860:AS188 RS08760
gene id: 446860:AS188_RS08760
uniprot id: A0A0U2NZG5
names: Similarity
messages: Belongs to the citrate synthase family.

446860:AS188 RS13255
gene id: 446860:AS188_RS13255
uniprot id: A0A0U3HJA1
names: Similarity
messages: Belongs to the DEAD box helicase family.

446860:AS188 RS13580
gene id: 446860:AS188_RS13580
uniprot id: A0A0U3GKB8
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

446860:AS188 RS15535
gene id: 446860:AS188_RS15535
uniprot id: A0A0U3HJ70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

446860:AS188 RS02705
gene id: 446860:AS188_RS02705
uniprot id: A0A0U3GHI1
names: Similarity
messages: Belongs to the FAD-binding monooxygenase family.

446860:AS188 RS08935
gene id: 446860:AS188_RS08935
uniprot id: A0A0U3G9S5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

446860:AS188 RS06935
gene id: 446860:AS188_RS06935
uniprot id: A0A0U2NYS1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS02855
gene id: 446860:AS188_RS02855
uniprot id: A0A0U3G1L7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

446860:AS188 RS15625
gene id: 446860:AS188_RS15625
uniprot id: A0A0U3G801
names: Similarity
messages: Belongs to the disproportionating enzyme family.

446860:AS188 RS04810
gene id: 446860:AS188_RS04810
uniprot id: A0A0U3GIL0
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS09340
gene id: 446860:AS188_RS09340
uniprot id: A0A0U3G9X9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

446860:AS188 RS12970
gene id: 446860:AS188_RS12970
uniprot id: A0A0U2XQN4
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS04425
gene id: 446860:AS188_RS04425
uniprot id: A0A0U3HNI7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

446860:AS188 RS15600
gene id: 446860:AS188_RS15600
uniprot id: A0A0U3HDA4
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

446860:AS188 RS11700
gene id: 446860:AS188_RS11700
uniprot id: A0A0U3HGL9
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS00925
gene id: 446860:AS188_RS00925
uniprot id: A0A0U3HLU0
names: Similarity
messages: Belongs to the UPF0423 family.

446860:AS188 RS06400
gene id: 446860:AS188_RS06400
uniprot id: A0A0U2XMA9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aminoglycoside phosphotransferase family.
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

446860:AS188 RS08910
gene id: 446860:AS188_RS08910
uniprot id: A0A0U3HGC0
names: Cofactor
names: Similarity
messages: Belongs to the class-II DAHP synthase family.
messages: Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.

446860:AS188 RS11975
gene id: 446860:AS188_RS11975
uniprot id: A0A0U2WVH2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

446860:AS188 RS10995
gene id: 446860:AS188_RS10995
uniprot id: A0A0U3I9V4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

446860:AS188 RS12585
gene id: 446860:AS188_RS12585
uniprot id: A0A0U3HBY8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

446860:AS188 RS12750
gene id: 446860:AS188_RS12750
uniprot id: A0A0U3GJZ7
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS05845
gene id: 446860:AS188_RS05845
uniprot id: A0A0U3HDV1
names: Similarity
messages: Belongs to the universal stress protein A family.

446860:AS188 RS05395
gene id: 446860:AS188_RS05395
uniprot id: A0A0U2YUR5
names: Similarity
messages: Belongs to the Dps family.

446860:AS188 RS15335
gene id: 446860:AS188_RS15335
uniprot id: A0A0U3HJ36
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS10360
gene id: 446860:AS188_RS10360
uniprot id: A0A0U2P013
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.

446860:AS188 RS04945
gene id: 446860:AS188_RS04945
uniprot id: A0A0U3HDF8
names: Function
names: Similarity
messages: Belongs to the uricase family.
messages: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.

446860:AS188 RS09655
gene id: 446860:AS188_RS09655
uniprot id: A0A0U2XSP7
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS14450
gene id: 446860:AS188_RS14450
uniprot id: A0A0U3HK78
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

446860:AS188 RS13890
gene id: 446860:AS188_RS13890
uniprot id: A0A0U2P1A6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

446860:AS188 RS00045
gene id: 446860:AS188_RS00045
uniprot id: A0A0U3HT45
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

446860:AS188 RS13220
gene id: 446860:AS188_RS13220
uniprot id: A0A0U3HI56
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS13990
gene id: 446860:AS188_RS13990
uniprot id: A0A0U3HZ11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

446860:AS188 RS11205
gene id: 446860:AS188_RS11205
uniprot id: A0A0U3HXX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

446860:AS188 RS01770
gene id: 446860:AS188_RS01770
uniprot id: A0A0U3GF73
names: Similarity
messages: Belongs to the universal stress protein A family.

446860:AS188 RS08395
gene id: 446860:AS188_RS08395
uniprot id: A0A0U3HQH4
names: Similarity
messages: Belongs to the ribF family.

446860:AS188 RS09245
gene id: 446860:AS188_RS09245
uniprot id: A0A0U3HX58
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS06795
gene id: 446860:AS188_RS06795
uniprot id: A0A0U3HPP8
names: Similarity
messages: Belongs to the hyi family.

446860:AS188 RS07265
gene id: 446860:AS188_RS07265
uniprot id: A0A0U2NYV7
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

446860:AS188 RS12615
gene id: 446860:AS188_RS12615
uniprot id: A0A0U3GBF1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

446860:AS188 RS16200
gene id: 446860:AS188_RS16200
uniprot id: A0A0U3G9L2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

446860:AS188 RS14110
gene id: 446860:AS188_RS14110
uniprot id: A0A0U3I0G0
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

446860:AS188 RS04060
gene id: 446860:AS188_RS04060
uniprot id: A0A0U2WRD7
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS07960
gene id: 446860:AS188_RS07960
uniprot id: A0A0U3HWL0
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

446860:AS188 RS02800
gene id: 446860:AS188_RS02800
uniprot id: A0A0U3GHJ2
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS00280
gene id: 446860:AS188_RS00280
uniprot id: A0A0U3HBB2
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

446860:AS188 RS17690
gene id: 446860:AS188_RS17690
uniprot id: A0A0U2XPH5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

446860:AS188 RS03205
gene id: 446860:AS188_RS03205
uniprot id: A0A0U3H7Q5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

446860:AS188 RS00880
gene id: 446860:AS188_RS00880
uniprot id: A0A0U2NWD8
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS00920
gene id: 446860:AS188_RS00920
uniprot id: A0A0U3H6S0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class II aldolase/RraA-like family.
messages: Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.
messages: Homotrimer.

446860:AS188 RS14085
gene id: 446860:AS188_RS14085
uniprot id: A0A0U3GNB1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

446860:AS188 RS14165
gene id: 446860:AS188_RS14165
uniprot id: A0A0U2YZ09
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

446860:AS188 RS11450
gene id: 446860:AS188_RS11450
uniprot id: A0A0U3HGH6
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

446860:AS188 RS13125
gene id: 446860:AS188_RS13125
uniprot id: A0A0U3G6W5
names: Similarity
messages: Belongs to the peptidase S1C family.

446860:AS188 RS10305
gene id: 446860:AS188_RS10305
uniprot id: A0A0U3HAX0
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

446860:AS188 RS12915
gene id: 446860:AS188_RS12915
uniprot id: A0A0U3HH59
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

446860:AS188 RS13275
gene id: 446860:AS188_RS13275
uniprot id: A0A0U2YYK5
names: Similarity
messages: Belongs to the peptidase M24B family.

446860:AS188 RS04630
gene id: 446860:AS188_RS04630
uniprot id: A0A0U3HW66
names: Function
names: Similarity
messages: Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysine residue in the mycobactin core.
messages: Belongs to the IucA/IucC family.

446860:AS188 RS00025
gene id: 446860:AS188_RS00025
uniprot id: A0A0U2NW41
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

446860:AS188 RS02060
gene id: 446860:AS188_RS02060
uniprot id: A0A0U3G6F3
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS14465
gene id: 446860:AS188_RS14465
uniprot id: A0A0U3GKL2
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS05210
gene id: 446860:AS188_RS05210
uniprot id: A0A0U3GIS8
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS03590
gene id: 446860:AS188_RS03590
uniprot id: A0A0U3HN15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCCT transporter (TC 2.A.15) family.
messages: Membrane

446860:AS188 RS15205
gene id: 446860:AS188_RS15205
uniprot id: A0A0U2WX27
names: Similarity
messages: Belongs to the peptidase C40 family.

446860:AS188 RS14135
gene id: 446860:AS188_RS14135
uniprot id: A0A0U3GC64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

446860:AS188 RS14620
gene id: 446860:AS188_RS14620
uniprot id: A0A0U3ID12
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS02620
gene id: 446860:AS188_RS02620
uniprot id: A0A0U3HV81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446860:AS188 RS12905
gene id: 446860:AS188_RS12905
uniprot id: A0A0U3HZX2
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

446860:AS188 RS08290
gene id: 446860:AS188_RS08290
uniprot id: A0A0U3HG03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

446860:AS188 RS02340
gene id: 446860:AS188_RS02340
uniprot id: A0A0U3G6L2
names: Similarity
messages: Belongs to the universal stress protein A family.

446860:AS188 RS07735
gene id: 446860:AS188_RS07735
uniprot id: A0A0U3I8H2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

446860:AS188 RS11735
gene id: 446860:AS188_RS11735
uniprot id: A0A0U3HY45
names: Similarity
messages: Belongs to the CsoR family.

446860:AS188 RS11035
gene id: 446860:AS188_RS11035
uniprot id: A0A0U2WV01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

446860:AS188 RS08085
gene id: 446860:AS188_RS08085
uniprot id: A0A0U3HXR7
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

446860:AS188 RS08095
gene id: 446860:AS188_RS08095
uniprot id: A0A0U3HEX0
names: Similarity
messages: Belongs to the transglycosylase family. Rpf subfamily.

446860:AS188 RS15460
gene id: 446860:AS188_RS15460
uniprot id: A0A0U3IBV4
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS14745
gene id: 446860:AS188_RS14745
uniprot id: A0A0U3HHZ0
names: Similarity
messages: Belongs to the GSP E family.

446860:AS188 RS17380
gene id: 446860:AS188_RS17380
uniprot id: A0A0U2P2F0
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

446860:AS188 RS15130
gene id: 446860:AS188_RS15130
uniprot id: A0A0U3HJ01
names: Similarity
messages: Belongs to the universal stress protein A family.

446860:AS188 RS14210
gene id: 446860:AS188_RS14210
uniprot id: A0A0U3HIK9
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
messages: Belongs to the nitrobindin family.
messages: Binds 1 heme b group per subunit, that coordinates a highly solvent-exposed Fe(III) atom.
messages: Forms a 10-stranded antiparallel beta-barrel structure able to accommodate a hydrophobic ligand in its interior. In fact, this fold hosts the heme group, which is located in a wide surface cleft.
messages: Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS14300
gene id: 446860:AS188_RS14300
uniprot id: A0A0U2WWK4
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS11185
gene id: 446860:AS188_RS11185
uniprot id: A0A0U2P0B9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm

446860:AS188 RS13920
gene id: 446860:AS188_RS13920
uniprot id: A0A0U2XR26
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

446860:AS188 RS13955
gene id: 446860:AS188_RS13955
uniprot id: A0A0U3HHK3
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

446860:AS188 RS12825
gene id: 446860:AS188_RS12825
uniprot id: A0A0U3HH43
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS09715
gene id: 446860:AS188_RS09715
uniprot id: A0A0U3HAL2
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

446860:AS188 RS09260
gene id: 446860:AS188_RS09260
uniprot id: A0A0U3GL15
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

446860:AS188 RS12695
gene id: 446860:AS188_RS12695
uniprot id: A0A0U3HC05
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS01305
gene id: 446860:AS188_RS01305
uniprot id: A0A0U3HTM7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

446860:AS188 RS01780
gene id: 446860:AS188_RS01780
uniprot id: A0A0U3HTY0
names: Similarity
messages: Belongs to the HSP15 family.

446860:AS188 RS10195
gene id: 446860:AS188_RS10195
uniprot id: A0A0U2WUJ3
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

446860:AS188 RS13215
gene id: 446860:AS188_RS13215
uniprot id: A0A0U3I015
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

446860:AS188 RS15440
gene id: 446860:AS188_RS15440
uniprot id: A0A0U3HI92
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

446860:AS188 RS13230
gene id: 446860:AS188_RS13230
uniprot id: A0A0U3HHA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.

446860:AS188 RS00145
gene id: 446860:AS188_RS00145
uniprot id: A0A0U2XIZ4
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

446860:AS188 RS15485
gene id: 446860:AS188_RS15485
uniprot id: A0A0U2YZK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

446860:AS188 RS04085
gene id: 446860:AS188_RS04085
uniprot id: A0A0U3HD20
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

446860:AS188 RS08630
gene id: 446860:AS188_RS08630
uniprot id: A0A0U3I8X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

446860:AS188 RS11610
gene id: 446860:AS188_RS11610
uniprot id: A0A0U3HGK6
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Electron transport system for the ribonucleotide reductase system NrdEF.

446860:AS188 RS04920
gene id: 446860:AS188_RS04920
uniprot id: A0A0U3H8H5
names: Similarity
messages: Belongs to the malate synthase family.

446860:AS188 RS12090
gene id: 446860:AS188_RS12090
uniprot id: A0A0U3HBR5
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

446860:AS188 RS14140
gene id: 446860:AS188_RS14140
uniprot id: A0A0U3IB98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

446860:AS188 RS00370
gene id: 446860:AS188_RS00370
uniprot id: A0A0U3HBC4
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

446860:AS188 RS13750
gene id: 446860:AS188_RS13750
uniprot id: A0A0U3I088
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

446860:AS188 RS11560
gene id: 446860:AS188_RS11560
uniprot id: A0A0U3HXQ6
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

446860:AS188 RS02205
gene id: 446860:AS188_RS02205
uniprot id: A0A0U2WQF6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

446860:AS188 RS10965
gene id: 446860:AS188_RS10965
uniprot id: A0A0U3HZ14
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

446860:AS188 RS13940
gene id: 446860:AS188_RS13940
uniprot id: A0A0U3HSW2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

446860:AS188 RS11965
gene id: 446860:AS188_RS11965
uniprot id: A0A0U3GMC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

446860:AS188 RS13980
gene id: 446860:AS188_RS13980
uniprot id: A0A0U3GKE9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

446860:AS188 RS10735
gene id: 446860:AS188_RS10735
uniprot id: A0A0U3GIZ6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

446860:AS188 RS07520
gene id: 446860:AS188_RS07520
uniprot id: A0A0U3G8P1
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS07535
gene id: 446860:AS188_RS07535
uniprot id: A0A0U3I8E6
names: Similarity
messages: Belongs to the universal stress protein A family.

446860:AS188 RS08625
gene id: 446860:AS188_RS08625
uniprot id: A0A0U3G9M4
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

446860:AS188 RS10840
gene id: 446860:AS188_RS10840
uniprot id: A0A0U2XPI8
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS05120
gene id: 446860:AS188_RS05120
uniprot id: A0A0U3GLD8
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS13790
gene id: 446860:AS188_RS13790
uniprot id: A0A0U2P192
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.

446860:AS188 RS08140
gene id: 446860:AS188_RS08140
uniprot id: A0A0U2YW34
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

446860:AS188 RS13700
gene id: 446860:AS188_RS13700
uniprot id: A0A0U2P177
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

446860:AS188 RS11660
gene id: 446860:AS188_RS11660
uniprot id: A0A0U2XPZ6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS02905
gene id: 446860:AS188_RS02905
uniprot id: A0A0U2XKG8
names: Similarity
messages: Belongs to the thioredoxin family.

446860:AS188 RS12640
gene id: 446860:AS188_RS12640
uniprot id: A0A0U3HY76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

446860:AS188 RS04685
gene id: 446860:AS188_RS04685
uniprot id: A0A0U3HV29
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

446860:AS188 RS11175
gene id: 446860:AS188_RS11175
uniprot id: A0A0U3GAR2
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

446860:AS188 RS00185
gene id: 446860:AS188_RS00185
uniprot id: A0A0U3HCD9
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS07900
gene id: 446860:AS188_RS07900
uniprot id: A0A0U2XSK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Membrane

446860:AS188 RS12735
gene id: 446860:AS188_RS12735
uniprot id: A0A0U3IAP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

446860:AS188 RS02590
gene id: 446860:AS188_RS02590
uniprot id: A0A0U3GHG6
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

446860:AS188 RS01255
gene id: 446860:AS188_RS01255
uniprot id: A0A0U3G605
names: Similarity
messages: Belongs to the AHA1 family.

446860:AS188 RS09810
gene id: 446860:AS188_RS09810
uniprot id: A0A0U3I1Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

446860:AS188 RS09645
gene id: 446860:AS188_RS09645
uniprot id: A0A0U3I9A7
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

446860:AS188 RS07060
gene id: 446860:AS188_RS07060
uniprot id: A0A0U3HVZ3
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

446860:AS188 RS10975
gene id: 446860:AS188_RS10975
uniprot id: A0A0U3HGA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Cytoplasm
messages: Homodimer.

446860:AS188 RS02850
gene id: 446860:AS188_RS02850
uniprot id: A0A0U3HCF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

446860:AS188 RS14275
gene id: 446860:AS188_RS14275
uniprot id: A0A0U2YZ25
names: Similarity
messages: Belongs to the UPF0336 family.

446860:AS188 RS01530
gene id: 446860:AS188_RS01530
uniprot id: A0A0U2WQ30
names: Function
messages: Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.

446860:AS188 RS11085
gene id: 446860:AS188_RS11085
uniprot id: A0A0U3I9X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

446860:AS188 RS03275
gene id: 446860:AS188_RS03275
uniprot id: A0A0U3HUH0
names: Similarity
messages: Belongs to the YciI family.

446860:AS188 RS05125
gene id: 446860:AS188_RS05125
uniprot id: A0A0U3H8K5
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS05885
gene id: 446860:AS188_RS05885
uniprot id: A0A0U3HVM4
names: Similarity
messages: Belongs to the phosphohexose mutase family.

446860:AS188 RS01650
gene id: 446860:AS188_RS01650
uniprot id: A0A0U3I5M2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

446860:AS188 RS09740
gene id: 446860:AS188_RS09740
uniprot id: A0A0U3G553
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS06045
gene id: 446860:AS188_RS06045
uniprot id: A0A0U2WXS8
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

446860:AS188 RS02530
gene id: 446860:AS188_RS02530
uniprot id: A0A0U3HCA5
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

446860:AS188 RS07460
gene id: 446860:AS188_RS07460
uniprot id: A0A0U3HW52
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS06635
gene id: 446860:AS188_RS06635
uniprot id: A0A0U3G3F1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

446860:AS188 RS08995
gene id: 446860:AS188_RS08995
uniprot id: A0A0U3GKU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

446860:AS188 RS11190
gene id: 446860:AS188_RS11190
uniprot id: A0A0U3GJ69
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.

446860:AS188 RS14670
gene id: 446860:AS188_RS14670
uniprot id: A0A0U3HZ45
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.

446860:AS188 RS13735
gene id: 446860:AS188_RS13735
uniprot id: A0A0U2WW97
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

446860:AS188 RS01105
gene id: 446860:AS188_RS01105
uniprot id: A0A0U3GGS3
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

446860:AS188 RS00910
gene id: 446860:AS188_RS00910
uniprot id: A0A0U3GGP5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

446860:AS188 RS11055
gene id: 446860:AS188_RS11055
uniprot id: A0A0U3HH96
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

446860:AS188 RS04530
gene id: 446860:AS188_RS04530
uniprot id: A0A0U3GIF2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LamB/PxpA family.
messages: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Forms a complex composed of PxpA, PxpB and PxpC.

446860:AS188 RS04940
gene id: 446860:AS188_RS04940
uniprot id: A0A0U3HEG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

446860:AS188 RS03910
gene id: 446860:AS188_RS03910
uniprot id: A0A0U3IDB2
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

446860:AS188 RS12295
gene id: 446860:AS188_RS12295
uniprot id: A0A0U3HBU3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

446860:AS188 RS02375
gene id: 446860:AS188_RS02375
uniprot id: A0A0U2YTD6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

446860:AS188 RS09045
gene id: 446860:AS188_RS09045
uniprot id: A0A0U3GPQ4
names: Subcellular Location Annotation
messages: Cytoplasm

446860:AS188 RS06990
gene id: 446860:AS188_RS06990
uniprot id: A0A0U3H9A6
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

446860:AS188 RS01080
gene id: 446860:AS188_RS01080
uniprot id: A0A0U3HTK9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS13925
gene id: 446860:AS188_RS13925
uniprot id: A0A0U3GN65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

446860:AS188 RS01355
gene id: 446860:AS188_RS01355
uniprot id: A0A0U3HBQ7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS15980
gene id: 446860:AS188_RS15980
uniprot id: A0A0U3G9E3
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS00150
gene id: 446860:AS188_RS00150
uniprot id: A0A0U3GGC3
names: Similarity
messages: Belongs to the pyruvate kinase family.

446860:AS188 RS07030
gene id: 446860:AS188_RS07030
uniprot id: A0A0U3ICG4
names: Similarity
messages: Belongs to the peptidase S8 family.

446860:AS188 RS14455
gene id: 446860:AS188_RS14455
uniprot id: A0A0U3IBE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

446860:AS188 RS09405
gene id: 446860:AS188_RS09405
uniprot id: A0A0U3HQZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

446860:AS188 RS15260
gene id: 446860:AS188_RS15260
uniprot id: A0A0U3IBS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane
messages: Membrane

446860:AS188 RS13520
gene id: 446860:AS188_RS13520
uniprot id: A0A0U2WW55
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

446860:AS188 RS01500
gene id: 446860:AS188_RS01500
uniprot id: A0A0U3GF32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446860:AS188 RS04540
gene id: 446860:AS188_RS04540
uniprot id: A0A0U3H8B7
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS00190
gene id: 446860:AS188_RS00190
uniprot id: A0A0U3HB98
names: Similarity
messages: Belongs to the acylphosphatase family.

446860:AS188 RS09050
gene id: 446860:AS188_RS09050
uniprot id: A0A0U2NZK3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

446860:AS188 RS12920
gene id: 446860:AS188_RS12920
uniprot id: A0A0U3G6T8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

446860:AS188 RS08190
gene id: 446860:AS188_RS08190
uniprot id: A0A0U3G4B6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

446860:AS188 RS04290
gene id: 446860:AS188_RS04290
uniprot id: A0A0U2NXT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

446860:AS188 RS15990
gene id: 446860:AS188_RS15990
uniprot id: A0A0U3IDB2
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

446860:AS188 RS14665
gene id: 446860:AS188_RS14665
uniprot id: A0A0U3GKP9
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

446860:AS188 RS01130
gene id: 446860:AS188_RS01130
uniprot id: A0A0U3HCS5
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

446860:AS188 RS09125
gene id: 446860:AS188_RS09125
uniprot id: A0A0U3G4U4
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

446860:AS188 RS14755
gene id: 446860:AS188_RS14755
uniprot id: A0A0U3GCG0
names: Similarity
messages: Belongs to the DNA polymerase type-A family.

446860:AS188 RS04960
gene id: 446860:AS188_RS04960
uniprot id: A0A0U3I7G7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

446860:AS188 RS01580
gene id: 446860:AS188_RS01580
uniprot id: A0A0U3GF39
names: Similarity
messages: Belongs to the UPF0045 family.

446860:AS188 RS02225
gene id: 446860:AS188_RS02225
uniprot id: A0A0U3HV31
names: Cofactor
names: Similarity
messages: Belongs to the peptidase S45 family.
messages: Binds 1 Ca(2+) ion per dimer.

446860:AS188 RS12800
gene id: 446860:AS188_RS12800
uniprot id: A0A0U3HSD3
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

446860:AS188 RS13985
gene id: 446860:AS188_RS13985
uniprot id: A0A0U3HYT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

446860:AS188 RS01360
gene id: 446860:AS188_RS01360
uniprot id: A0A0U3G0T4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

446860:AS188 RS07865
gene id: 446860:AS188_RS07865
uniprot id: A0A0U2YVY1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.

446860:AS188 RS08265
gene id: 446860:AS188_RS08265
uniprot id: A0A0U3G8Q3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS00320
gene id: 446860:AS188_RS00320
uniprot id: A0A0U3HT75
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

446860:AS188 RS14770
gene id: 446860:AS188_RS14770
uniprot id: A0A0U2P1M3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

446860:AS188 RS08975
gene id: 446860:AS188_RS08975
uniprot id: A0A0U3HWP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

446860:AS188 RS05305
gene id: 446860:AS188_RS05305
uniprot id: A0A0U2YUQ0
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

446860:AS188 RS14440
gene id: 446860:AS188_RS14440
uniprot id: A0A0U3G7G2
names: Similarity
messages: Belongs to the isochorismate synthase family.

446860:AS188 RS12290
gene id: 446860:AS188_RS12290
uniprot id: A0A0U2WVM3
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS08885
gene id: 446860:AS188_RS08885
uniprot id: A0A0U3GKS8
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

446860:AS188 RS05130
gene id: 446860:AS188_RS05130
uniprot id: A0A0U3HNV0
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

446860:AS188 RS12785
gene id: 446860:AS188_RS12785
uniprot id: A0A0U3GMN8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

446860:AS188 RS09890
gene id: 446860:AS188_RS09890
uniprot id: A0A0U3G8U5
names: Similarity
messages: Belongs to the peptidase M1 family.

446860:AS188 RS15575
gene id: 446860:AS188_RS15575
uniprot id: A0A0U3HZP9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

446860:AS188 RS03660
gene id: 446860:AS188_RS03660
uniprot id: A0A0U3HUM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

446860:AS188 RS12755
gene id: 446860:AS188_RS12755
uniprot id: A0A0U3HY92
names: Similarity
messages: Belongs to the polysaccharide synthase family.

446860:AS188 RS13565
gene id: 446860:AS188_RS13565
uniprot id: A0A0U3GBW3
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

446860:AS188 RS13670
gene id: 446860:AS188_RS13670
uniprot id: A0A0U3HIB9
names: Similarity
messages: Belongs to the UDPGP type 2 family.

446860:AS188 RS14150
gene id: 446860:AS188_RS14150
uniprot id: A0A0U3GKF9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

446860:AS188 RS09300
gene id: 446860:AS188_RS09300
uniprot id: A0A0U3HYB8
names: Similarity
messages: Belongs to the SufE family.

446860:AS188 RS13910
gene id: 446860:AS188_RS13910
uniprot id: A0A0U3HYZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

446860:AS188 RS14225
gene id: 446860:AS188_RS14225
uniprot id: A0A0U3GC78
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. MshD subfamily.
messages: Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

446860:AS188 RS12105
gene id: 446860:AS188_RS12105
uniprot id: A0A0U3HZJ5
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

446860:AS188 RS01375
gene id: 446860:AS188_RS01375
uniprot id: A0A0U2XRY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

446860:AS188 RS08160
gene id: 446860:AS188_RS08160
uniprot id: A0A0U3H9V1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

446860:AS188 RS02040
gene id: 446860:AS188_RS02040
uniprot id: A0A0U3HV04
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS09485
gene id: 446860:AS188_RS09485
uniprot id: A0A0U3HX78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

446860:AS188 RS03635
gene id: 446860:AS188_RS03635
uniprot id: A0A0U3I6N4
names: Similarity
messages: Belongs to the peptidase C40 family.

446860:AS188 RS16105
gene id: 446860:AS188_RS16105
uniprot id: A0A0U2Z113
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

446860:AS188 RS08025
gene id: 446860:AS188_RS08025
uniprot id: A0A0U3I8M5
names: Similarity
messages: Belongs to the YciI family.

446860:AS188 RS13145
gene id: 446860:AS188_RS13145
uniprot id: A0A0U2P114
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane

446860:AS188 RS02265
gene id: 446860:AS188_RS02265
uniprot id: A0A0U3GFD9
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS14065
gene id: 446860:AS188_RS14065
uniprot id: A0A0U3HYV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

446860:AS188 RS13770
gene id: 446860:AS188_RS13770
uniprot id: A0A0U3G762
names: Function
names: Similarity
messages: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.

446860:AS188 RS07605
gene id: 446860:AS188_RS07605
uniprot id: A0A0U3HFP3
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

446860:AS188 RS07405
gene id: 446860:AS188_RS07405
uniprot id: A0A0U3HPZ5
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS04890
gene id: 446860:AS188_RS04890
uniprot id: A0A0U3HUZ7
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

446860:AS188 RS05045
gene id: 446860:AS188_RS05045
uniprot id: A0A0U3HDH0
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS00665
gene id: 446860:AS188_RS00665
uniprot id: A0A0U3HBG5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

446860:AS188 RS00090
gene id: 446860:AS188_RS00090
uniprot id: A0A0U3HB86
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

446860:AS188 RS09010
gene id: 446860:AS188_RS09010
uniprot id: A0A0U3HQT4
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

446860:AS188 RS13995
gene id: 446860:AS188_RS13995
uniprot id: A0A0U2YYX9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

446860:AS188 RS04670
gene id: 446860:AS188_RS04670
uniprot id: A0A0U3GGD1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

446860:AS188 RS11310
gene id: 446860:AS188_RS11310
uniprot id: A0A0U2XPT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

446860:AS188 RS13865
gene id: 446860:AS188_RS13865
uniprot id: A0A0U3G780
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic pantothenate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS06385
gene id: 446860:AS188_RS06385
uniprot id: A0A0U3HVN6
names: Function
names: Similarity
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

446860:AS188 RS10560
gene id: 446860:AS188_RS10560
uniprot id: A0A0U2P2Q5
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS14420
gene id: 446860:AS188_RS14420
uniprot id: A0A0U3HT36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

446860:AS188 RS04405
gene id: 446860:AS188_RS04405
uniprot id: A0A0U2XL92
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS14905
gene id: 446860:AS188_RS14905
uniprot id: A0A0U3GNN7
names: Similarity
messages: Belongs to the GSP E family.

446860:AS188 RS14780
gene id: 446860:AS188_RS14780
uniprot id: A0A0U3HZ65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

446860:AS188 RS02885
gene id: 446860:AS188_RS02885
uniprot id: A0A0U3GFL2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

446860:AS188 RS07250
gene id: 446860:AS188_RS07250
uniprot id: A0A0U3G915
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS05920
gene id: 446860:AS188_RS05920
uniprot id: A0A0U3HP86
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS08255
gene id: 446860:AS188_RS08255
uniprot id: A0A0U2XNB8
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

446860:AS188 RS13420
gene id: 446860:AS188_RS13420
uniprot id: A0A0U3HCC2
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS09680
gene id: 446860:AS188_RS09680
uniprot id: A0A0U3HWZ1
names: Similarity
messages: Belongs to the DapA family.

446860:AS188 RS10170
gene id: 446860:AS188_RS10170
uniprot id: A0A0U3HXG2
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS12715
gene id: 446860:AS188_RS12715
uniprot id: A0A0U3HHZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

446860:AS188 RS02990
gene id: 446860:AS188_RS02990
uniprot id: A0A0U3HUC6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

446860:AS188 RS05050
gene id: 446860:AS188_RS05050
uniprot id: A0A0U3G2P1
names: Similarity
messages: Belongs to the ABC transporter superfamily.

446860:AS188 RS08585
gene id: 446860:AS188_RS08585
uniprot id: A0A0U2WTT6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

446860:AS188 RS07230
gene id: 446860:AS188_RS07230
uniprot id: A0A0U3HFJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

446860:AS188 RS10770
gene id: 446860:AS188_RS10770
uniprot id: A0A0U2WUT6
names: Similarity
messages: Belongs to the Pup ligase/Pup deamidase family. Pup deamidase subfamily.

446860:AS188 RS13915
gene id: 446860:AS188_RS13915
uniprot id: A0A0U2YYW0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

446860:AS188 RS11335
gene id: 446860:AS188_RS11335
uniprot id: A0A0U3HRW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

446860:AS188 RS15530
gene id: 446860:AS188_RS15530
uniprot id: A0A0U3I141
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

446860:AS188 RS14685
gene id: 446860:AS188_RS14685
uniprot id: A0A0U3HZA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

446860:AS188 RS08795
gene id: 446860:AS188_RS08795
uniprot id: A0A0U2WTY2
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS02160
gene id: 446860:AS188_RS02160
uniprot id: A0A0U3G6H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family.
messages: Membrane

446860:AS188 RS13900
gene id: 446860:AS188_RS13900
uniprot id: A0A0U3GKE4
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

446860:AS188 RS01540
gene id: 446860:AS188_RS01540
uniprot id: A0A0U3HM30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

446860:AS188 RS07840
gene id: 446860:AS188_RS07840
uniprot id: A0A512I3M6
names: Caution
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

446860:AS188 RS13260
gene id: 446860:AS188_RS13260
uniprot id: A0A0U3GK68
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

446860:AS188 RS13505
gene id: 446860:AS188_RS13505
uniprot id: A0A0U2XQW1
names: Cofactor
messages: Binds 4 [4Fe-4S] clusters per subunit.

446860:AS188 RS05425
gene id: 446860:AS188_RS05425
uniprot id: A0A0U3HNZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

446860:AS188 RS07650
gene id: 446860:AS188_RS07650
uniprot id: A0A0U3GHN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

446860:AS188 RS03565
gene id: 446860:AS188_RS03565
uniprot id: A0A0U2YTX1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

446860:AS188 RS01810
gene id: 446860:AS188_RS01810
uniprot id: A0A0U3H752
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

446860:AS188 RS05950
gene id: 446860:AS188_RS05950
uniprot id: A0A0U3I7R8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

446860:AS188 RS06645
gene id: 446860:AS188_RS06645
uniprot id: A0A0U3I803
names: Similarity
messages: Belongs to the peptidase C40 family.

446860:AS188 RS13755
gene id: 446860:AS188_RS13755
uniprot id: A0A0U3HJB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

446860:AS188 RS03005
gene id: 446860:AS188_RS03005
uniprot id: A0A0U3GHM0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

446860:AS188 RS14240
gene id: 446860:AS188_RS14240
uniprot id: A0A0U3IBC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

446860:AS188 RS08660
gene id: 446860:AS188_RS08660
uniprot id: A0A0U2YWD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

446860:AS188 RS11970
gene id: 446860:AS188_RS11970
uniprot id: A0A0U3HUF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

446860:AS188 RS08965
gene id: 446860:AS188_RS08965
uniprot id: A0A0U3GI81
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS10910
gene id: 446860:AS188_RS10910
uniprot id: A0A0U3GJ28
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

446860:AS188 RS14020
gene id: 446860:AS188_RS14020
uniprot id: A0A0U3HSX7
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

446860:AS188 RS12645
gene id: 446860:AS188_RS12645
uniprot id: A0A0U2WYA4
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

446860:AS188 RS06525
gene id: 446860:AS188_RS06525
uniprot id: A0A0U3HX22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

446860:AS188 RS00485
gene id: 446860:AS188_RS00485
uniprot id: A0A0U3I4Z8
names: Similarity
messages: Belongs to the FPG family.

446860:AS188 RS14645
gene id: 446860:AS188_RS14645
uniprot id: A0A0U3GCE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

446860:AS188 RS13855
gene id: 446860:AS188_RS13855
uniprot id: A0A0U3HIF0
names: Similarity
messages: Belongs to the mannitol dehydrogenase family.

446860:AS188 RS03745
gene id: 446860:AS188_RS03745
uniprot id: A0A0U3GFY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

446860:AS188 RS08365
gene id: 446860:AS188_RS08365
uniprot id: A0A0U2XND1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

446860:AS188 RS02925
gene id: 446860:AS188_RS02925
uniprot id: A0A0U3H7L6
names: Similarity
messages: Belongs to the Nudix hydrolase family.

446860:AS188 RS00355
gene id: 446860:AS188_RS00355
uniprot id: A0A0U3HLJ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

446860:AS188 RS10740
gene id: 446860:AS188_RS10740
uniprot id: A0A0U3HXD3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
messages: Monomer.

446860:AS188 RS01595
gene id: 446860:AS188_RS01595
uniprot id: A0A0U2YT07
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the CobB/CobQ family.
messages: Involved in acetate metabolism.
messages: The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site.

446860:AS188 RS09590
gene id: 446860:AS188_RS09590
uniprot id: A0A0U2WUA6
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS08145
gene id: 446860:AS188_RS08145
uniprot id: A0A0U2XN97
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

446860:AS188 RS08705
gene id: 446860:AS188_RS08705
uniprot id: A0A0U3HA63
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS15520
gene id: 446860:AS188_RS15520
uniprot id: A0A0U3HEE1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS06830
gene id: 446860:AS188_RS06830
uniprot id: A0A0U3I831
names: Subcellular Location Annotation
messages: Cytoplasm

446860:AS188 RS10415
gene id: 446860:AS188_RS10415
uniprot id: A0A0U3HYT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell membrane
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.

446860:AS188 RS17655
gene id: 446860:AS188_RS17655
uniprot id: A0A0U3HNN5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.

446860:AS188 RS02520
gene id: 446860:AS188_RS02520
uniprot id: A0A0U3HDD3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 3 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

446860:AS188 RS00770
gene id: 446860:AS188_RS00770
uniprot id: A0A0U3HBI1
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

446860:AS188 RS06080
gene id: 446860:AS188_RS06080
uniprot id: A0A0U3I1K1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

446860:AS188 RS15580
gene id: 446860:AS188_RS15580
uniprot id: A0A0U2YZN3
names: Similarity
messages: Belongs to the DyP-type peroxidase family.

446860:AS188 RS14175
gene id: 446860:AS188_RS14175
uniprot id: A0A0U3GNC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

446860:AS188 RS12135
gene id: 446860:AS188_RS12135
uniprot id: A0A0U3IAF0
names: Function
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

446860:AS188 RS01660
gene id: 446860:AS188_RS01660
uniprot id: A0A0U3GF58
names: Similarity
messages: Belongs to the Nudix hydrolase family.

446860:AS188 RS11595
gene id: 446860:AS188_RS11595
uniprot id: A0A0U3HRZ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
messages: Tetramer of two alpha and two beta subunits.

446860:AS188 RS01455
gene id: 446860:AS188_RS01455
uniprot id: A0A0U3HBS5
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

446860:AS188 RS09865
gene id: 446860:AS188_RS09865
uniprot id: A0A0U3GIM1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

446860:AS188 RS14130
gene id: 446860:AS188_RS14130
uniprot id: A0A0U3G7C0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

446860:AS188 RS11910
gene id: 446860:AS188_RS11910
uniprot id: A0A0U3HHM5
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

446860:AS188 RS06395
gene id: 446860:AS188_RS06395
uniprot id: A0A0U2YV76
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. TreS subfamily.

446860:AS188 RS07975
gene id: 446860:AS188_RS07975
uniprot id: A0A0U2XN63
names: Similarity
messages: Belongs to the thioesterase family.

446860:AS188 RS11570
gene id: 446860:AS188_RS11570
uniprot id: A0A0U2YXS2
names: Function
names: Similarity
messages: Belongs to the transposase IS30 family.
messages: Required for the transposition of the insertion element.

446860:AS188 RS06315
gene id: 446860:AS188_RS06315
uniprot id: A0A0U3GJB0
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

446860:AS188 RS14030
gene id: 446860:AS188_RS14030
uniprot id: A0A0U3HIH7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

446860:AS188 RS09630
gene id: 446860:AS188_RS09630
uniprot id: A0A0U3HFN4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

446860:AS188 RS11895
gene id: 446860:AS188_RS11895
uniprot id: A0A0U3HZF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

446860:AS188 RS12320
gene id: 446860:AS188_RS12320
uniprot id: A0A0U3HGW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

446860:AS188 RS08350
gene id: 446860:AS188_RS08350
uniprot id: A0A0U3HWR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

446860:AS188 RS13795
gene id: 446860:AS188_RS13795
uniprot id: A0A0U3GKD6
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

446860:AS188 RS09355
gene id: 446860:AS188_RS09355
uniprot id: A0A0U3GID4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

446860:AS188 RS16055
gene id: 446860:AS188_RS16055
uniprot id: A0A0U2Z0U6
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

446860:AS188 RS13635
gene id: 446860:AS188_RS13635
uniprot id: A0A0U3GN18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

446860:AS188 RS13400
gene id: 446860:AS188_RS13400
uniprot id: A0A0U3I0S4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

446860:AS188 RS09035
gene id: 446860:AS188_RS09035
uniprot id: A0A0U3G9U1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

446860:AS188 RS13485
gene id: 446860:AS188_RS13485
uniprot id: A0A0U3HYK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm

446860:AS188 RS12810
gene id: 446860:AS188_RS12810
uniprot id: A0A0U3HZV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

446860:AS188 RS11265
gene id: 446860:AS188_RS11265
uniprot id: A0A0U3HGE8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

446860:AS188 RS11115
gene id: 446860:AS188_RS11115
uniprot id: A0A0U2YXI6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS07375
gene id: 446860:AS188_RS07375
uniprot id: A0A0U3HW88
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

446860:AS188 RS09430
gene id: 446860:AS188_RS09430
uniprot id: A0A0U3HFK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

446860:AS188 RS08355
gene id: 446860:AS188_RS08355
uniprot id: A0A0U2YW75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

446860:AS188 RS15605
gene id: 446860:AS188_RS15605
uniprot id: A0A0U3HTL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

446860:AS188 RS08115
gene id: 446860:AS188_RS08115
uniprot id: A0A0U3I8P0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

446860:AS188 RS09395
gene id: 446860:AS188_RS09395
uniprot id: A0A0U2WU67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

446860:AS188 RS12505
gene id: 446860:AS188_RS12505
uniprot id: A0A0U3HGZ2
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

446860:AS188 RS03555
gene id: 446860:AS188_RS03555
uniprot id: A0A0U3HUF3
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

446860:AS188 RS04880
gene id: 446860:AS188_RS04880
uniprot id: A0A0U3GGG6
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS10370
gene id: 446860:AS188_RS10370
uniprot id: A0A0U3HX87
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

446860:AS188 RS01600
gene id: 446860:AS188_RS01600
uniprot id: A0A0U2XJV8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

446860:AS188 RS04280
gene id: 446860:AS188_RS04280
uniprot id: A0A0U3G7L5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

446860:AS188 RS11150
gene id: 446860:AS188_RS11150
uniprot id: A0A0U3HZ40
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

446860:AS188 RS15100
gene id: 446860:AS188_RS15100
uniprot id: A0A0U2XRK9
names: Similarity
messages: Belongs to the CsoR family.

446860:AS188 RS01805
gene id: 446860:AS188_RS01805
uniprot id: A0A0U2WQ90
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

446860:AS188 RS01085
gene id: 446860:AS188_RS01085
uniprot id: A0A0U2YSS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

446860:AS188 RS01180
gene id: 446860:AS188_RS01180
uniprot id: A0A0U3HTM3
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

446860:AS188 RS04855
gene id: 446860:AS188_RS04855
uniprot id: A0A0U3G7X7
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

446860:AS188 RS08500
gene id: 446860:AS188_RS08500
uniprot id: A0A0U3HA16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

446860:AS188 RS15830
gene id: 446860:AS188_RS15830
uniprot id: A0A0U3I103
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

446860:AS188 RS12390
gene id: 446860:AS188_RS12390
uniprot id: A0A0U2XSW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

446860:AS188 RS02875
gene id: 446860:AS188_RS02875
uniprot id: A0A0U2NX89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

446860:AS188 RS15005
gene id: 446860:AS188_RS15005
uniprot id: A0A0U2WWY8
names: Similarity
messages: Belongs to the SAICAR synthetase family.

446860:AS188 RS04235
gene id: 446860:AS188_RS04235
uniprot id: A0A0U2WRG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

446860:AS188 RS04270
gene id: 446860:AS188_RS04270
uniprot id: A0A0U3HD60
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

446860:AS188 RS07675
gene id: 446860:AS188_RS07675
uniprot id: A0A0U3GK25
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS02310
gene id: 446860:AS188_RS02310
uniprot id: A0A0U3HV39
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS15405
gene id: 446860:AS188_RS15405
uniprot id: A0A0U2WX56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

446860:AS188 RS11235
gene id: 446860:AS188_RS11235
uniprot id: A0A0U3HBC2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS09085
gene id: 446860:AS188_RS09085
uniprot id: A0A0U3GKW4
names: Similarity
messages: Belongs to the glutamine synthetase family.

446860:AS188 RS06865
gene id: 446860:AS188_RS06865
uniprot id: A0A0U2YVE7
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

446860:AS188 RS04135
gene id: 446860:AS188_RS04135
uniprot id: A0A0U2YU66
names: Similarity
messages: Belongs to the CapA family.

446860:AS188 RS11995
gene id: 446860:AS188_RS11995
uniprot id: A0A0U3HS62
names: Similarity
messages: Belongs to the FPG family.

446860:AS188 RS09090
gene id: 446860:AS188_RS09090
uniprot id: A0A0U2WU26
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS03530
gene id: 446860:AS188_RS03530
uniprot id: A0A0U3G1X2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS07875
gene id: 446860:AS188_RS07875
uniprot id: A0A0U3GK64
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

446860:AS188 RS06460
gene id: 446860:AS188_RS06460
uniprot id: A0A0U3G8P9
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.

446860:AS188 RS07670
gene id: 446860:AS188_RS07670
uniprot id: A0A0U2XN16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

446860:AS188 RS01005
gene id: 446860:AS188_RS01005
uniprot id: A0A0U3GGQ9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

446860:AS188 RS11275
gene id: 446860:AS188_RS11275
uniprot id: A0A0U3GAT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

446860:AS188 RS01555
gene id: 446860:AS188_RS01555
uniprot id: A0A0U3HBT8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

446860:AS188 RS06505
gene id: 446860:AS188_RS06505
uniprot id: A0A0U3GJE2
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS01775
gene id: 446860:AS188_RS01775
uniprot id: A0A0U3HTP3
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS10335
gene id: 446860:AS188_RS10335
uniprot id: A0A0U2Z0U6
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

446860:AS188 RS07665
gene id: 446860:AS188_RS07665
uniprot id: A0A0U2YVU1
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS13240
gene id: 446860:AS188_RS13240
uniprot id: A0A0U3GBQ7
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

446860:AS188 RS05755
gene id: 446860:AS188_RS05755
uniprot id: A0A0U3G8D7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

446860:AS188 RS09030
gene id: 446860:AS188_RS09030
uniprot id: A0A0U3G4S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DivIVA family.
messages: Cytoplasm

446860:AS188 RS13840
gene id: 446860:AS188_RS13840
uniprot id: A0A0U3HSU8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS06630
gene id: 446860:AS188_RS06630
uniprot id: A0A0U3HE84
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.

446860:AS188 RS14195
gene id: 446860:AS188_RS14195
uniprot id: A0A0U3HT05
names: Function
names: Similarity
names: Subunit
messages: Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.
messages: Homotetramer.
messages: Uses inorganic polyphosphate (polyP) as a donor to convert GDP to GTP or ADP to ATP.

446860:AS188 RS09380
gene id: 446860:AS188_RS09380
uniprot id: A0A0U2YWR8
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

446860:AS188 RS05070
gene id: 446860:AS188_RS05070
uniprot id: A0A0U3GGK1
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

446860:AS188 RS09075
gene id: 446860:AS188_RS09075
uniprot id: A0A0U2YWM5
names: Similarity
messages: Belongs to the glutamine synthetase family.

446860:AS188 RS03155
gene id: 446860:AS188_RS03155
uniprot id: A0A0U3G6Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

446860:AS188 RS09800
gene id: 446860:AS188_RS09800
uniprot id: A0A0U2WUD4
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

446860:AS188 RS01970
gene id: 446860:AS188_RS01970
uniprot id: A0A0U2P254
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS15165
gene id: 446860:AS188_RS15165
uniprot id: A0A0U3GKW1
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS01685
gene id: 446860:AS188_RS01685
uniprot id: A0A0U2XJW8
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS10930
gene id: 446860:AS188_RS10930
uniprot id: A0A0U2YXF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

446860:AS188 RS07920
gene id: 446860:AS188_RS07920
uniprot id: A0A0U3HET8
names: Function
messages: Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors.

446860:AS188 RS05995
gene id: 446860:AS188_RS05995
uniprot id: A0A0U3GJ61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

446860:AS188 RS13445
gene id: 446860:AS188_RS13445
uniprot id: A0A0U3HI90
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates zinc uptake. May also transport other divalent cations.
messages: Membrane

446860:AS188 RS02995
gene id: 446860:AS188_RS02995
uniprot id: A0A0U2YTM6
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS06360
gene id: 446860:AS188_RS06360
uniprot id: A0A0U3G8N2
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

446860:AS188 RS15680
gene id: 446860:AS188_RS15680
uniprot id: A0A0U3HKB3
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

446860:AS188 RS06495
gene id: 446860:AS188_RS06495
uniprot id: A0A0U2YV84
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

446860:AS188 RS10990
gene id: 446860:AS188_RS10990
uniprot id: A0A0U3GAN8
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS12025
gene id: 446860:AS188_RS12025
uniprot id: A0A0U3GB65
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

446860:AS188 RS11040
gene id: 446860:AS188_RS11040
uniprot id: A0A0U3HB85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

446860:AS188 RS13175
gene id: 446860:AS188_RS13175
uniprot id: A0A0U3HE80
names: Similarity
messages: Belongs to the Nudix hydrolase family.

446860:AS188 RS07010
gene id: 446860:AS188_RS07010
uniprot id: A0A0U3HFE8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

446860:AS188 RS07950
gene id: 446860:AS188_RS07950
uniprot id: A0A0U3GHU0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

446860:AS188 RS15075
gene id: 446860:AS188_RS15075
uniprot id: A0A0U2YX82
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

446860:AS188 RS08470
gene id: 446860:AS188_RS08470
uniprot id: A0A0U3HWS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

446860:AS188 RS07940
gene id: 446860:AS188_RS07940
uniprot id: A0A0U3I8K8
names: Similarity
messages: Belongs to the universal stress protein A family.

446860:AS188 RS09065
gene id: 446860:AS188_RS09065
uniprot id: A0A0U3HWR0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

446860:AS188 RS14470
gene id: 446860:AS188_RS14470
uniprot id: A0A0U3HZ10
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

446860:AS188 RS12730
gene id: 446860:AS188_RS12730
uniprot id: A0A0U3GBG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

446860:AS188 RS13265
gene id: 446860:AS188_RS13265
uniprot id: A0A0U3HYH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

446860:AS188 RS10380
gene id: 446860:AS188_RS10380
uniprot id: A0A0U2YX67
names: Similarity
names: Subunit
messages: Belongs to the pyruvate kinase family.
messages: Homotetramer.

446860:AS188 RS02715
gene id: 446860:AS188_RS02715
uniprot id: A0A0U3H7I5
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS02155
gene id: 446860:AS188_RS02155
uniprot id: A0A0U3G162
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

446860:AS188 RS17310
gene id: 446860:AS188_RS17310
uniprot id: A0A0U3HU61
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS05550
gene id: 446860:AS188_RS05550
uniprot id: A0A0U3HWM9
names: Function
names: Similarity
messages: Belongs to the catalase family. HPII subfamily.
messages: Serves to protect cells from the toxic effects of hydrogen peroxide.

446860:AS188 RS03100
gene id: 446860:AS188_RS03100
uniprot id: A0A0U2Z0U6
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

446860:AS188 RS02385
gene id: 446860:AS188_RS02385
uniprot id: A0A0U2XK95
names: Similarity
messages: Belongs to the asparagine synthetase family.

446860:AS188 RS09140
gene id: 446860:AS188_RS09140
uniprot id: A0A0U2NZL3
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS03180
gene id: 446860:AS188_RS03180
uniprot id: A0A0U3HUF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Membrane

446860:AS188 RS12795
gene id: 446860:AS188_RS12795
uniprot id: A0A0U3HC17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

446860:AS188 RS09470
gene id: 446860:AS188_RS09470
uniprot id: A0A0U2NZP9
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase Eis family.
messages: Homohexamer; trimer of dimers.

446860:AS188 RS08325
gene id: 446860:AS188_RS08325
uniprot id: A0A0U3I8R6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

446860:AS188 RS04510
gene id: 446860:AS188_RS04510
uniprot id: A0A0U2YUC8
names: Similarity
messages: Belongs to the D-glutamate cyclase family.

446860:AS188 RS01920
gene id: 446860:AS188_RS01920
uniprot id: A0A0U3HD51
names: Similarity
messages: Belongs to the CmpA/NrtA family.

446860:AS188 RS06595
gene id: 446860:AS188_RS06595
uniprot id: A0A0U2WSK6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

446860:AS188 RS10190
gene id: 446860:AS188_RS10190
uniprot id: A0A0U3GLE9
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

446860:AS188 RS09400
gene id: 446860:AS188_RS09400
uniprot id: A0A0U3HAH3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

446860:AS188 RS13860
gene id: 446860:AS188_RS13860
uniprot id: A0A0U3HHJ0
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Homodimer.
messages: Membrane

446860:AS188 RS08485
gene id: 446860:AS188_RS08485
uniprot id: A0A0U2XNF0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

446860:AS188 RS01390
gene id: 446860:AS188_RS01390
uniprot id: A0A0U3GF04
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

446860:AS188 RS12220
gene id: 446860:AS188_RS12220
uniprot id: A0A0U3HHR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

446860:AS188 RS13945
gene id: 446860:AS188_RS13945
uniprot id: A0A0U3I0C1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

446860:AS188 RS14040
gene id: 446860:AS188_RS14040
uniprot id: A0A0U3G7A8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

446860:AS188 RS02305
gene id: 446860:AS188_RS02305
uniprot id: A0A0U3HMG1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

446860:AS188 RS11145
gene id: 446860:AS188_RS11145
uniprot id: A0A0U3HRS8
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS03570
gene id: 446860:AS188_RS03570
uniprot id: A0A0U2XKU9
names: Similarity
messages: Belongs to the GcvT family.

446860:AS188 RS06365
gene id: 446860:AS188_RS06365
uniprot id: A0A0U3I7X0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS05510
gene id: 446860:AS188_RS05510
uniprot id: A0A0U2XLS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0719 family.
messages: Membrane

446860:AS188 RS11950
gene id: 446860:AS188_RS11950
uniprot id: A0A0U3HY71
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

446860:AS188 RS09020
gene id: 446860:AS188_RS09020
uniprot id: A0A0U3HGD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

446860:AS188 RS07985
gene id: 446860:AS188_RS07985
uniprot id: A0A0U2WTD5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

446860:AS188 RS00465
gene id: 446860:AS188_RS00465
uniprot id: A0A0U3HCI7
names: Similarity
messages: Belongs to the adrenodoxin/putidaredoxin family.

446860:AS188 RS13535
gene id: 446860:AS188_RS13535
uniprot id: A0A0U3I053
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

446860:AS188 RS14200
gene id: 446860:AS188_RS14200
uniprot id: A0A0U3I0H9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS16075
gene id: 446860:AS188_RS16075
uniprot id: A0A0U3GE91
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

446860:AS188 RS02860
gene id: 446860:AS188_RS02860
uniprot id: A0A0U3G8D0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

446860:AS188 RS07115
gene id: 446860:AS188_RS07115
uniprot id: A0A0U3HEG3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

446860:AS188 RS06140
gene id: 446860:AS188_RS06140
uniprot id: A0A0U3HDZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

446860:AS188 RS12200
gene id: 446860:AS188_RS12200
uniprot id: A0A0U3HS87
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

446860:AS188 RS05090
gene id: 446860:AS188_RS05090
uniprot id: A0A0U2YUM0
names: Similarity
messages: Belongs to the peptidase S8 family.

446860:AS188 RS08005
gene id: 446860:AS188_RS08005
uniprot id: A0A0U3HFW0
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS05475
gene id: 446860:AS188_RS05475
uniprot id: A0A0U3I7L6
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS02770
gene id: 446860:AS188_RS02770
uniprot id: A0A0U2NX80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

446860:AS188 RS03150
gene id: 446860:AS188_RS03150
uniprot id: A0A0U3G1Q5
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS05660
gene id: 446860:AS188_RS05660
uniprot id: A0A0U3G874
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Membrane

446860:AS188 RS08725
gene id: 446860:AS188_RS08725
uniprot id: A0A0U3HG91
names: Similarity
messages: Belongs to the TlyA family.

446860:AS188 RS02455
gene id: 446860:AS188_RS02455
uniprot id: A0A0U3HTY8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

446860:AS188 RS12575
gene id: 446860:AS188_RS12575
uniprot id: A0A0U3GMK9
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS08985
gene id: 446860:AS188_RS08985
uniprot id: A0A0U2YWK1
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS05405
gene id: 446860:AS188_RS05405
uniprot id: A0A0U3GIW2
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS13070
gene id: 446860:AS188_RS13070
uniprot id: A0A0U3GMT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

446860:AS188 RS15780
gene id: 446860:AS188_RS15780
uniprot id: A0A0U3HKC9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

446860:AS188 RS05790
gene id: 446860:AS188_RS05790
uniprot id: A0A0U2YUX3
names: Similarity
messages: Belongs to the UPF0098 family.

446860:AS188 RS06095
gene id: 446860:AS188_RS06095
uniprot id: A0A0U2YV17
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.

446860:AS188 RS06155
gene id: 446860:AS188_RS06155
uniprot id: A0A0U3I7U3
names: Similarity
messages: Belongs to the PhoU family.

446860:AS188 RS01590
gene id: 446860:AS188_RS01590
uniprot id: A0A0U3HTV3
names: Similarity
messages: Belongs to the CsoR family.

446860:AS188 RS00545
gene id: 446860:AS188_RS00545
uniprot id: A0A0U3H6L1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

446860:AS188 RS12005
gene id: 446860:AS188_RS12005
uniprot id: A0A0U3HHP0
names: Similarity
messages: Belongs to the peptidase M1 family.

446860:AS188 RS10290
gene id: 446860:AS188_RS10290
uniprot id: A0A0U2XPA0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

446860:AS188 RS13720
gene id: 446860:AS188_RS13720
uniprot id: A0A0U2YYS8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

446860:AS188 RS10570
gene id: 446860:AS188_RS10570
uniprot id: A0A0U3HXA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

446860:AS188 RS10670
gene id: 446860:AS188_RS10670
uniprot id: A0A0U3GLM2
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS06915
gene id: 446860:AS188_RS06915
uniprot id: A0A0U3G3L2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

446860:AS188 RS09005
gene id: 446860:AS188_RS09005
uniprot id: A0A0U3HAA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

446860:AS188 RS11400
gene id: 446860:AS188_RS11400
uniprot id: A0A0U2XPV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

446860:AS188 RS14980
gene id: 446860:AS188_RS14980
uniprot id: A0A0U3HZF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

446860:AS188 RS12495
gene id: 446860:AS188_RS12495
uniprot id: A0A0U3HZR2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

446860:AS188 RS04365
gene id: 446860:AS188_RS04365
uniprot id: A0A0U3G2D3
names: Similarity
messages: Belongs to the glutathione peroxidase family.

446860:AS188 RS00350
gene id: 446860:AS188_RS00350
uniprot id: A0A0U3H6H7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

446860:AS188 RS15495
gene id: 446860:AS188_RS15495
uniprot id: A0A0U2XRT4
names: Subcellular Location Annotation
messages: Membrane

446860:AS188 RS00640
gene id: 446860:AS188_RS00640
uniprot id: A0A0U3H6M5
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.

446860:AS188 RS11230
gene id: 446860:AS188_RS11230
uniprot id: A0A0U2WV50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

446860:AS188 RS09625
gene id: 446860:AS188_RS09625
uniprot id: A0A0U3HGM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm