42254:GH1
gene id: 42254:GH1
uniprot id: A0A0M6L0Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
messages: Secreted

42254:IFNB1
gene id: 42254:IFNB1
uniprot id: A0A7R8C3U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

42254:ERGIC3
gene id: 42254:ERGIC3
uniprot id: B3RF49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

42254:STEAP2
gene id: 42254:STEAP2
uniprot id: B3EX04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

42254:NR2E1
gene id: 42254:NR2E1
uniprot id: B3RF24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

42254:LOC101553197
gene id: 42254:LOC101553197
uniprot id: B3RF95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

42254:HOXA2
gene id: 42254:HOXA2
uniprot id: B3RFG0
names: Subcellular Location Annotation
messages: Nucleus

42254:MGRG3
gene id: 42254:MGRG3
uniprot id: W8W3R5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

42254:LALBA
gene id: 42254:LALBA
uniprot id: A0A077S9R8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).
messages: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

42254:IRF1
gene id: 42254:IRF1
uniprot id: B3RF60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Nucleus

42254:STEAP1
gene id: 42254:STEAP1
uniprot id: B3EX03
names: Subcellular Location Annotation
messages: Membrane

42254:CCN2
gene id: 42254:CCN2
uniprot id: B3EX53
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

42254:MFAP1
gene id: 42254:MFAP1
uniprot id: B3RF14
names: Function
names: Similarity
messages: Belongs to the MFAP1 family.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.

42254:RTCB
gene id: 42254:RTCB
uniprot id: B3RF81
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Catalytic component of the tRNA-splicing ligase complex.
messages: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.
messages: Cytoplasm
messages: Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.

42254:IL10
gene id: 42254:IL10
uniprot id: A0A7R8C3W7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-10 family.
messages: Homodimer. Interacts with IL10RA and IL10RB.
messages: Immune regulatory cytokine.
messages: Secreted

42254:GJA10
gene id: 42254:GJA10
uniprot id: A0A654IDX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

42254:LOC101556387
gene id: 42254:LOC101556387
uniprot id: A0A1K0FUH4
names: Similarity
messages: Belongs to the globin family.

42254:SNX3
gene id: 42254:SNX3
uniprot id: B3RF25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome
messages: Endosome
messages: phagosome

42254:PATZ1
gene id: 42254:PATZ1
uniprot id: B3RF72
names: Subcellular Location Annotation
messages: Nucleus

42254:LOC101552932
gene id: 42254:LOC101552932
uniprot id: B3RF94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

42254:MEN1
gene id: 42254:MEN1
uniprot id: B3RF41
names: Subcellular Location Annotation
messages: Nucleus

42254:LOC101540389
gene id: 42254:LOC101540389
uniprot id: B3RF65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

42254:FGF7
gene id: 42254:FGF7
uniprot id: A0A7U3JWD8
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

42254:LOC101553932
gene id: 42254:LOC101553932
uniprot id: B3EX28
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.

42254:GDF5
gene id: 42254:GDF5
uniprot id: B3RF47
names: Similarity
messages: Belongs to the TGF-beta family.

42254:FGF21
gene id: 42254:FGF21
uniprot id: A0A7U3JWF5
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

42254:RNASE1
gene id: 42254:RNASE1
uniprot id: W0UVH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

42254:OLR145 2
gene id: 42254:OLR145_2
uniprot id: B3RFB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

42254:LOC101548536
gene id: 42254:LOC101548536
uniprot id: A0A7R8C3I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family.
messages: Secreted

42254:LOC101552878
gene id: 42254:LOC101552878
uniprot id: B3EX31
names: Similarity
messages: Belongs to the globin family.

42254:OLFR569
gene id: 42254:OLFR569
uniprot id: B3RF89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

42254:DOLK
gene id: 42254:DOLK
uniprot id: B3EX67
names: Similarity
messages: Belongs to the polyprenol kinase family.

42254:BMP4
gene id: 42254:BMP4
uniprot id: B3RF16
names: Similarity
messages: Belongs to the TGF-beta family.

42254:MGRG5
gene id: 42254:MGRG5
uniprot id: W8W3L1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

42254:EXT1
gene id: 42254:EXT1
uniprot id: B3RF18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

42254:SERPINB7
gene id: 42254:SERPINB7
uniprot id: B3RFC2
names: Similarity
messages: Belongs to the serpin family.

42254:PI4KB
gene id: 42254:PI4KB
uniprot id: B3EX61
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.
messages: Endomembrane system
messages: Golgi apparatus
messages: Golgi apparatus membrane
messages: Inhibited by wortmannin. Increased kinase activity upon interaction with NCS1/FREQ.
messages: Interacts with ARF1 and ARF3 in the Golgi complex, but not with ARF4, ARF5 or ARF6 (By similarity). Interacts with NCS1/FREQ in a calcium-independent manner. Interacts with CALN1/CABP8 and CALN2/CABP7; in a calcium-dependent manner; this interaction competes with NCS1/FREQ binding (By similarity). Interacts with ACBD3. Interacts with ARMH3, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ and SFN (By similarity). Interacts with GGA2 (via VHS domain); the interaction is important for PI4KB location at the Golgi apparatus membrane (By similarity). Interacts with ATG9A.
messages: Mitochondrion outer membrane
messages: Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity). Involved in Golgi-to-plasma membrane trafficking (By similarity). May play an important role in the inner ear development.
messages: Rough endoplasmic reticulum membrane

42254:HOXA9
gene id: 42254:HOXA9
uniprot id: B3RFG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

42254:HBM
gene id: 42254:HBM
uniprot id: B3EX30
names: Similarity
messages: Belongs to the globin family.

42254:LOC101544465
gene id: 42254:LOC101544465
uniprot id: B3RFB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

42254:LOC101541634
gene id: 42254:LOC101541634
uniprot id: B3RF75
names: Similarity
messages: Belongs to the CWC15 family.

42254:LOC101553142
gene id: 42254:LOC101553142
uniprot id: B3EX31
names: Similarity
messages: Belongs to the globin family.

42254:LOC101547041
gene id: 42254:LOC101547041
uniprot id: B3RFD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane

42254:TTR
gene id: 42254:TTR
uniprot id: O46654
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the transthyretin family.
messages: Detected in serum (at protein level). Detected in liver.
messages: Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4 (By similarity).
messages: Secreted
messages: Sulfonation of the reactive cysteine Cys-30 enhances the stability of the native conformation of TTR, avoiding misassembly of the protein leading to amyloid formation.
messages: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

42254:NFS1
gene id: 42254:NFS1
uniprot id: B3RF52
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

42254:RPL10
gene id: 42254:RPL10
uniprot id: B3RFD9
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

42254:OLFR605
gene id: 42254:OLFR605
uniprot id: B3RFA4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

42254:LOC101540387
gene id: 42254:LOC101540387
uniprot id: B3RF09
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

42254:ATP5PO
gene id: 42254:ATP5PO
uniprot id: B3EX21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity).
messages: Mitochondrion
messages: Mitochondrion inner membrane

42254:TNP1
gene id: 42254:TNP1
uniprot id: F7VJM7
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear transition protein 1 family.
messages: Chromosome
messages: Nucleus
messages: The sequence shown here is derived from an EMBL/GenBank/DDBJ third party annotation (TPA) entry.

42254:GRM8
gene id: 42254:GRM8
uniprot id: B3EX10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

42254:EEF1A1
gene id: 42254:EEF1A1
uniprot id: B3EX57
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

42254:LOC101553667
gene id: 42254:LOC101553667
uniprot id: B3EX28
names: Function
names: Similarity
messages: Belongs to the globin family.
messages: The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.

42254:FSHB
gene id: 42254:FSHB
uniprot id: A0A0F7RPW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

42254:MGRG2
gene id: 42254:MGRG2
uniprot id: W8W3H5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

42254:NPRL3
gene id: 42254:NPRL3
uniprot id: B3EX27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.
messages: Belongs to the NPR3 family.
messages: Lysosome