420247:MSM RS03710
gene id: 420247:MSM_RS03710
uniprot id: A5UL70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

420247:MSM RS07190
gene id: 420247:MSM_RS07190
uniprot id: A5UN55
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.
messages: X-ray crystallography in other archaea shows this protein binds a 3Fe-4S cluster, although a 4Fe-4S cluster has been suggested to be present in this protein.

420247:MSM RS06805
gene id: 420247:MSM_RS06805
uniprot id: A5UMX8
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

420247:MSM RS08215
gene id: 420247:MSM_RS08215
uniprot id: A5UNR6
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS04155
gene id: 420247:MSM_RS04155
uniprot id: A5ULG0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

420247:MSM RS01425
gene id: 420247:MSM_RS01425
uniprot id: A5UJW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

420247:MSM RS03270
gene id: 420247:MSM_RS03270
uniprot id: A5UKY0
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

420247:MSM RS07755
gene id: 420247:MSM_RS07755
uniprot id: A5UNH6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

420247:MSM RS06080
gene id: 420247:MSM_RS06080
uniprot id: A5UMI0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

420247:MSM RS04700
gene id: 420247:MSM_RS04700
uniprot id: A5ULR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

420247:MSM RS04200
gene id: 420247:MSM_RS04200
uniprot id: A5ULG9
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

420247:MSM RS02925
gene id: 420247:MSM_RS02925
uniprot id: A5UKR0
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS06925
gene id: 420247:MSM_RS06925
uniprot id: A5UN01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

420247:MSM RS03720
gene id: 420247:MSM_RS03720
uniprot id: A5UL72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

420247:MSM RS03010
gene id: 420247:MSM_RS03010
uniprot id: A5UKS9
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

420247:MSM RS05245
gene id: 420247:MSM_RS05245
uniprot id: A5UM19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

420247:MSM RS00915
gene id: 420247:MSM_RS00915
uniprot id: A5UJL5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

420247:MSM RS08540
gene id: 420247:MSM_RS08540
uniprot id: A5UNY4
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

420247:MSM RS00955
gene id: 420247:MSM_RS00955
uniprot id: A5UJM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

420247:MSM RS03770
gene id: 420247:MSM_RS03770
uniprot id: A5UL82
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

420247:MSM RS06485
gene id: 420247:MSM_RS06485
uniprot id: A5UMR1
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

420247:MSM RS06470
gene id: 420247:MSM_RS06470
uniprot id: A5UMQ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiX family. CbiXS subfamily.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
messages: Homotetramer; dimer of dimers.

420247:MSM RS06560
gene id: 420247:MSM_RS06560
uniprot id: A5UMS6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

420247:MSM RS06940
gene id: 420247:MSM_RS06940
uniprot id: A5UN04
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

420247:MSM RS06910
gene id: 420247:MSM_RS06910
uniprot id: A5UMZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

420247:MSM RS00590
gene id: 420247:MSM_RS00590
uniprot id: A5UJE8
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

420247:MSM RS07460
gene id: 420247:MSM_RS07460
uniprot id: A5UNB1
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS03920
gene id: 420247:MSM_RS03920
uniprot id: A5ULB3
names: Similarity
messages: Belongs to the intimin/invasin family.

420247:MSM RS01070
gene id: 420247:MSM_RS01070
uniprot id: A5UJP7
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

420247:MSM RS01135
gene id: 420247:MSM_RS01135
uniprot id: A5UJR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

420247:MSM RS04540
gene id: 420247:MSM_RS04540
uniprot id: A5ULN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

420247:MSM RS03310
gene id: 420247:MSM_RS03310
uniprot id: A5UKY8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

420247:MSM RS06360
gene id: 420247:MSM_RS06360
uniprot id: A5UMN6
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

420247:MSM RS03705
gene id: 420247:MSM_RS03705
uniprot id: A5UL69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

420247:MSM RS05270
gene id: 420247:MSM_RS05270
uniprot id: A5UM24
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

420247:MSM RS03685
gene id: 420247:MSM_RS03685
uniprot id: A5UL65
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

420247:MSM RS04150
gene id: 420247:MSM_RS04150
uniprot id: A5ULF9
names: Similarity
messages: Belongs to the aspartokinase family.

420247:MSM RS06850
gene id: 420247:MSM_RS06850
uniprot id: A5UMY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

420247:MSM RS07795
gene id: 420247:MSM_RS07795
uniprot id: A5UNI4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

420247:MSM RS01900
gene id: 420247:MSM_RS01900
uniprot id: A5UK61
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

420247:MSM RS00365
gene id: 420247:MSM_RS00365
uniprot id: A5UJA4
names: Similarity
messages: Belongs to the thymidylate kinase family.

420247:MSM RS06900
gene id: 420247:MSM_RS06900
uniprot id: A5UMZ6
names: Similarity
messages: Belongs to the Nudix hydrolase family.

420247:MSM RS06760
gene id: 420247:MSM_RS06760
uniprot id: A5UMW7
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

420247:MSM RS05725
gene id: 420247:MSM_RS05725
uniprot id: A5UMA9
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

420247:MSM RS00150
gene id: 420247:MSM_RS00150
uniprot id: A5UJ60
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

420247:MSM RS06040
gene id: 420247:MSM_RS06040
uniprot id: A5UMH2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

420247:MSM RS04505
gene id: 420247:MSM_RS04505
uniprot id: A5ULM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

420247:MSM RS01785
gene id: 420247:MSM_RS01785
uniprot id: A5UK38
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the small carbamoyl-phosphate synthase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Catalyzes the synthesis of carbamoyl phosphate from ATP, ammonium and bicarbonate. Proceeds via a three-step mechanism, i.e. the phosphorylation of hydrogencarbonate to carboxyphosphate, a nucleophilic attack of ammonia on carboxyphosphate yielding carbamate, and the phosphorylation of carbamate forming carbamoyl phosphate. In M.smithii, the predominant archaeon in the human gut, one function of this enzyme may be to sequester ammonia, a scarce nutrient in the intestine which is the major source of nitrogen in M.smithii for the biosynthesis of nucleotides, amino acids, and many other metabolites.
messages: Forms homodimers and homotetramers (dimers of dimers).
messages: Lacks the domain involved in allosteric regulation present in CarB CPSases.
messages: Several lines of evidence suggest that obesity is associated with elevated levels of intestinal methanogenic archaea. Consequently, this enzyme may be an attractive drug target in the treatment of human obesity.

420247:MSM RS06700
gene id: 420247:MSM_RS06700
uniprot id: A5UMV4
names: Similarity
messages: Belongs to the CDP-glycerol glycerophosphotransferase family.

420247:MSM RS02410
gene id: 420247:MSM_RS02410
uniprot id: A5UKG5
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

420247:MSM RS05080
gene id: 420247:MSM_RS05080
uniprot id: A5ULY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrF family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

420247:MSM RS01130
gene id: 420247:MSM_RS01130
uniprot id: A5UJR0
names: Function
names: Similarity
messages: Belongs to the P(II) protein family.
messages: Could be involved in the regulation of nitrogen fixation.

420247:MSM RS00610
gene id: 420247:MSM_RS00610
uniprot id: A5UJF2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

420247:MSM RS06980
gene id: 420247:MSM_RS06980
uniprot id: A5UN14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

420247:MSM RS05110
gene id: 420247:MSM_RS05110
uniprot id: A5ULZ2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

420247:MSM RS02110
gene id: 420247:MSM_RS02110
uniprot id: A5UKA4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Binds two Mg(2+) per subunit.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome.

420247:MSM RS06275
gene id: 420247:MSM_RS06275
uniprot id: A5UML9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

420247:MSM RS08045
gene id: 420247:MSM_RS08045
uniprot id: A5UNN1
names: Similarity
messages: Belongs to the UDPGP type 2 family.

420247:MSM RS03280
gene id: 420247:MSM_RS03280
uniprot id: A5UKY2
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

420247:MSM RS04930
gene id: 420247:MSM_RS04930
uniprot id: A5ULV6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

420247:MSM RS00605
gene id: 420247:MSM_RS00605
uniprot id: A5UJF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

420247:MSM RS06175
gene id: 420247:MSM_RS06175
uniprot id: A5UMJ9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.

420247:MSM RS05200
gene id: 420247:MSM_RS05200
uniprot id: A5UM10
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

420247:MSM RS01150
gene id: 420247:MSM_RS01150
uniprot id: A5UJR4
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

420247:MSM RS00980
gene id: 420247:MSM_RS00980
uniprot id: A5UJM8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

420247:MSM RS02830
gene id: 420247:MSM_RS02830
uniprot id: A5UKP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

420247:MSM RS03735
gene id: 420247:MSM_RS03735
uniprot id: A5UL75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

420247:MSM RS05240
gene id: 420247:MSM_RS05240
uniprot id: A5UM18
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

420247:MSM RS03575
gene id: 420247:MSM_RS03575
uniprot id: A5UL43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

420247:MSM RS06500
gene id: 420247:MSM_RS06500
uniprot id: A5UMR4
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

420247:MSM RS03805
gene id: 420247:MSM_RS03805
uniprot id: A5UL89
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

420247:MSM RS06035
gene id: 420247:MSM_RS06035
uniprot id: A5UMH1
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

420247:MSM RS03520
gene id: 420247:MSM_RS03520
uniprot id: A5UL31
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

420247:MSM RS07320
gene id: 420247:MSM_RS07320
uniprot id: A5UN82
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
messages: Homodimer.
messages: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.

420247:MSM RS03120
gene id: 420247:MSM_RS03120
uniprot id: A5UKV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

420247:MSM RS08165
gene id: 420247:MSM_RS08165
uniprot id: A5UNQ6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

420247:MSM RS02980
gene id: 420247:MSM_RS02980
uniprot id: A5UKS3
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS06170
gene id: 420247:MSM_RS06170
uniprot id: A5UMJ8
names: Similarity
messages: Belongs to the UPF0285 family.

420247:MSM RS06145
gene id: 420247:MSM_RS06145
uniprot id: A5UMJ2
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

420247:MSM RS07715
gene id: 420247:MSM_RS07715
uniprot id: A5UNG7
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

420247:MSM RS06065
gene id: 420247:MSM_RS06065
uniprot id: A5UMH7
names: Similarity
messages: Belongs to the UPF0284 family.

420247:MSM RS07195
gene id: 420247:MSM_RS07195
uniprot id: A5UN56
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

420247:MSM RS01175
gene id: 420247:MSM_RS01175
uniprot id: A5UJR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

420247:MSM RS06935
gene id: 420247:MSM_RS06935
uniprot id: A5UN03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

420247:MSM RS01180
gene id: 420247:MSM_RS01180
uniprot id: A5UJS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

420247:MSM RS04135
gene id: 420247:MSM_RS04135
uniprot id: A5ULF6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

420247:MSM RS01010
gene id: 420247:MSM_RS01010
uniprot id: A5UJN4
names: Similarity
messages: Belongs to the UPF0251 family.

420247:MSM RS05755
gene id: 420247:MSM_RS05755
uniprot id: A5UMB5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CobB/CobQ family. GatD subfamily.
messages: Forms a heterodimer with MurT.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT.

420247:MSM RS04165
gene id: 420247:MSM_RS04165
uniprot id: A5ULG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

420247:MSM RS03165
gene id: 420247:MSM_RS03165
uniprot id: A5UKW0
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

420247:MSM RS01820
gene id: 420247:MSM_RS01820
uniprot id: A5UK45
names: Similarity
messages: Belongs to the glutamate synthase family.

420247:MSM RS03860
gene id: 420247:MSM_RS03860
uniprot id: A5ULA0
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS01705
gene id: 420247:MSM_RS01705
uniprot id: A5UK24
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

420247:MSM RS04915
gene id: 420247:MSM_RS04915
uniprot id: A5ULV3
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

420247:MSM RS07215
gene id: 420247:MSM_RS07215
uniprot id: A5UN60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

420247:MSM RS01845
gene id: 420247:MSM_RS01845
uniprot id: A5UK50
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

420247:MSM RS03290
gene id: 420247:MSM_RS03290
uniprot id: A5UKY4
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

420247:MSM RS00895
gene id: 420247:MSM_RS00895
uniprot id: A5UJL1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the creatininase superfamily. FAPy deformylase family.
messages: Catalyzes the hydrolysis of the formamide of 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy).
messages: Homodimer.
messages: Requires an additional second metal ion that could be Fe(2+) or Zn(2+).
messages: Requires one Fe(2+) ion for activity.

420247:MSM RS06580
gene id: 420247:MSM_RS06580
uniprot id: A5UMT0
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Homotetramer; probably dimer of dimers.

420247:MSM RS05665
gene id: 420247:MSM_RS05665
uniprot id: A5UM99
names: Similarity
messages: Belongs to the FrhG family.

420247:MSM RS02890
gene id: 420247:MSM_RS02890
uniprot id: A5UKQ5
names: Similarity
messages: Belongs to the UPF0254 family.

420247:MSM RS00255
gene id: 420247:MSM_RS00255
uniprot id: A5UJ81
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

420247:MSM RS00250
gene id: 420247:MSM_RS00250
uniprot id: A5UJ80
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

420247:MSM RS01460
gene id: 420247:MSM_RS01460
uniprot id: A5UJX5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

420247:MSM RS03700
gene id: 420247:MSM_RS03700
uniprot id: A5UL68
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

420247:MSM RS01105
gene id: 420247:MSM_RS01105
uniprot id: A5UJQ5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

420247:MSM RS00140
gene id: 420247:MSM_RS00140
uniprot id: A5UJ57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Probably functions as a manganese efflux pump.

420247:MSM RS02535
gene id: 420247:MSM_RS02535
uniprot id: A5UKJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

420247:MSM RS06770
gene id: 420247:MSM_RS06770
uniprot id: A5UMW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

420247:MSM RS04645
gene id: 420247:MSM_RS04645
uniprot id: A5ULP9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

420247:MSM RS05990
gene id: 420247:MSM_RS05990
uniprot id: A5UMG2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

420247:MSM RS02155
gene id: 420247:MSM_RS02155
uniprot id: A5UKB3
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

420247:MSM RS03580
gene id: 420247:MSM_RS03580
uniprot id: A5UL44
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

420247:MSM RS05230
gene id: 420247:MSM_RS05230
uniprot id: A5UM16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

420247:MSM RS05505
gene id: 420247:MSM_RS05505
uniprot id: A5UM73
names: Function
messages: Part of a potassium transport system.

420247:MSM RS04455
gene id: 420247:MSM_RS04455
uniprot id: A5ULL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

420247:MSM RS02940
gene id: 420247:MSM_RS02940
uniprot id: A5UKR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

420247:MSM RS04565
gene id: 420247:MSM_RS04565
uniprot id: A5ULN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.
messages: Part of the RNA polymerase complex.

420247:MSM RS01200
gene id: 420247:MSM_RS01200
uniprot id: A5UJS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

420247:MSM RS06185
gene id: 420247:MSM_RS06185
uniprot id: A5UMK1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

420247:MSM RS04990
gene id: 420247:MSM_RS04990
uniprot id: A5ULW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: In the C-terminal section; belongs to the OsmX family.
messages: In the N-terminal section; belongs to the binding-protein-dependent transport system permease family.

420247:MSM RS08770
gene id: 420247:MSM_RS08770
uniprot id: A5UP31
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS05780
gene id: 420247:MSM_RS05780
uniprot id: A5UMC0
names: Similarity
messages: Belongs to the TrpC family.

420247:MSM RS04275
gene id: 420247:MSM_RS04275
uniprot id: A5ULI2
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.

420247:MSM RS03365
gene id: 420247:MSM_RS03365
uniprot id: A5UKZ8
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

420247:MSM RS06380
gene id: 420247:MSM_RS06380
uniprot id: A5UMP0
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

420247:MSM RS05495
gene id: 420247:MSM_RS05495
uniprot id: A5UM71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0104 family.
messages: Membrane

420247:MSM RS00945
gene id: 420247:MSM_RS00945
uniprot id: A5UJM1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

420247:MSM RS06075
gene id: 420247:MSM_RS06075
uniprot id: A5UMH9
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

420247:MSM RS05345
gene id: 420247:MSM_RS05345
uniprot id: A5UM39
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS00595
gene id: 420247:MSM_RS00595
uniprot id: A5UJE9
names: Similarity
messages: Belongs to the HerA family.

420247:MSM RS05975
gene id: 420247:MSM_RS05975
uniprot id: A5UMF9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

420247:MSM RS00655
gene id: 420247:MSM_RS00655
uniprot id: A5UJG1
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

420247:MSM RS07505
gene id: 420247:MSM_RS07505
uniprot id: A5UNC0
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS04240
gene id: 420247:MSM_RS04240
uniprot id: A5ULH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

420247:MSM RS08180
gene id: 420247:MSM_RS08180
uniprot id: A5UNQ9
names: Function
messages: Probably involved in the biogenesis of the ribosome.

420247:MSM RS03850
gene id: 420247:MSM_RS03850
uniprot id: A5UL98
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS04310
gene id: 420247:MSM_RS04310
uniprot id: A5ULI9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

420247:MSM RS02815
gene id: 420247:MSM_RS02815
uniprot id: A5UKP0
names: Similarity
messages: Belongs to the class-I fumarase family.

420247:MSM RS06695
gene id: 420247:MSM_RS06695
uniprot id: A5UMV3
names: Similarity
messages: Belongs to the ABC transporter superfamily.

420247:MSM RS06290
gene id: 420247:MSM_RS06290
uniprot id: A5UMM2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

420247:MSM RS01395
gene id: 420247:MSM_RS01395
uniprot id: A5UJW2
names: Similarity
messages: Belongs to the UPF0179 family.

420247:MSM RS03890
gene id: 420247:MSM_RS03890
uniprot id: A5ULA6
names: Similarity
messages: Belongs to the UPF0173 family.

420247:MSM RS06395
gene id: 420247:MSM_RS06395
uniprot id: A5UMP3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

420247:MSM RS01185
gene id: 420247:MSM_RS01185
uniprot id: A5UJS1
names: Similarity
messages: Belongs to the SDO1/SBDS family.

420247:MSM RS07005
gene id: 420247:MSM_RS07005
uniprot id: A5UN19
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity.

420247:MSM RS07750
gene id: 420247:MSM_RS07750
uniprot id: A5UNH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

420247:MSM RS04630
gene id: 420247:MSM_RS04630
uniprot id: A5ULP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

420247:MSM RS04535
gene id: 420247:MSM_RS04535
uniprot id: A5ULN2
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

420247:MSM RS02055
gene id: 420247:MSM_RS02055
uniprot id: A5UK92
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.

420247:MSM RS01405
gene id: 420247:MSM_RS01405
uniprot id: A5UJW4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

420247:MSM RS08200
gene id: 420247:MSM_RS08200
uniprot id: A5UNR3
names: Similarity
messages: Belongs to the HisA/HisF family.

420247:MSM RS02415
gene id: 420247:MSM_RS02415
uniprot id: A5UKG6
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

420247:MSM RS02590
gene id: 420247:MSM_RS02590
uniprot id: A5UKK1
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

420247:MSM RS07765
gene id: 420247:MSM_RS07765
uniprot id: A5UNH8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

420247:MSM RS03615
gene id: 420247:MSM_RS03615
uniprot id: A5UL52
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

420247:MSM RS03305
gene id: 420247:MSM_RS03305
uniprot id: A5UKY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

420247:MSM RS01365
gene id: 420247:MSM_RS01365
uniprot id: A5UJV6
names: Similarity
messages: Belongs to the UPF0047 family.

420247:MSM RS02160
gene id: 420247:MSM_RS02160
uniprot id: A5UKB4
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

420247:MSM RS04470
gene id: 420247:MSM_RS04470
uniprot id: A5ULM1
names: Similarity
messages: Belongs to the UPF0146 family.

420247:MSM RS05770
gene id: 420247:MSM_RS05770
uniprot id: A5UMB8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

420247:MSM RS07075
gene id: 420247:MSM_RS07075
uniprot id: A5UN33
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

420247:MSM RS01715
gene id: 420247:MSM_RS01715
uniprot id: A5UK27
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
messages: Homodimer.

420247:MSM RS02500
gene id: 420247:MSM_RS02500
uniprot id: A5UKI3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

420247:MSM RS06740
gene id: 420247:MSM_RS06740
uniprot id: A5UMW3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

420247:MSM RS00950
gene id: 420247:MSM_RS00950
uniprot id: A5UJM2
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

420247:MSM RS01120
gene id: 420247:MSM_RS01120
uniprot id: A5UJQ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.

420247:MSM RS06330
gene id: 420247:MSM_RS06330
uniprot id: A5UMN0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

420247:MSM RS00685
gene id: 420247:MSM_RS00685
uniprot id: A5UJG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

420247:MSM RS06200
gene id: 420247:MSM_RS06200
uniprot id: A5UMK4
names: Cofactor
names: Similarity
messages: Belongs to the GARS family.
messages: Binds 2 magnesium or manganese ions per subunit.

420247:MSM RS07240
gene id: 420247:MSM_RS07240
uniprot id: A5UN66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

420247:MSM RS03900
gene id: 420247:MSM_RS03900
uniprot id: A5ULA8
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS07805
gene id: 420247:MSM_RS07805
uniprot id: A5UNI6
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS01400
gene id: 420247:MSM_RS01400
uniprot id: A5UJW3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm
messages: Homooctamer.

420247:MSM RS04105
gene id: 420247:MSM_RS04105
uniprot id: A5ULF0
names: Function
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

420247:MSM RS06255
gene id: 420247:MSM_RS06255
uniprot id: A5UML5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

420247:MSM RS00905
gene id: 420247:MSM_RS00905
uniprot id: A5UJL3
names: Similarity
messages: Belongs to the IMPACT family.

420247:MSM RS00445
gene id: 420247:MSM_RS00445
uniprot id: A5UJC0
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS02435
gene id: 420247:MSM_RS02435
uniprot id: A5UKH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

420247:MSM RS02115
gene id: 420247:MSM_RS02115
uniprot id: A5UKA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

420247:MSM RS07670
gene id: 420247:MSM_RS07670
uniprot id: A5UNF8
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS06735
gene id: 420247:MSM_RS06735
uniprot id: A5UMW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

420247:MSM RS02095
gene id: 420247:MSM_RS02095
uniprot id: A5UKA1
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

420247:MSM RS01335
gene id: 420247:MSM_RS01335
uniprot id: A5UJV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

420247:MSM RS05150
gene id: 420247:MSM_RS05150
uniprot id: A5UM00
names: Similarity
messages: Belongs to the ComB family.

420247:MSM RS01695
gene id: 420247:MSM_RS01695
uniprot id: A5UK22
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

420247:MSM RS03930
gene id: 420247:MSM_RS03930
uniprot id: A5ULB5
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

420247:MSM RS02440
gene id: 420247:MSM_RS02440
uniprot id: A5UKH1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

420247:MSM RS00985
gene id: 420247:MSM_RS00985
uniprot id: A5UJM9
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

420247:MSM RS03205
gene id: 420247:MSM_RS03205
uniprot id: A5UKW7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

420247:MSM RS03115
gene id: 420247:MSM_RS03115
uniprot id: A5UKV0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

420247:MSM RS05420
gene id: 420247:MSM_RS05420
uniprot id: A5UM55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

420247:MSM RS05730
gene id: 420247:MSM_RS05730
uniprot id: A5UMB0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

420247:MSM RS08115
gene id: 420247:MSM_RS08115
uniprot id: A5UNP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

420247:MSM RS00645
gene id: 420247:MSM_RS00645
uniprot id: A5UJF9
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

420247:MSM RS03350
gene id: 420247:MSM_RS03350
uniprot id: A5UKZ5
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

420247:MSM RS06765
gene id: 420247:MSM_RS06765
uniprot id: A5UMW8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

420247:MSM RS07590
gene id: 420247:MSM_RS07590
uniprot id: A5UNE0
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

420247:MSM RS03335
gene id: 420247:MSM_RS03335
uniprot id: A5UKZ2
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

420247:MSM RS03100
gene id: 420247:MSM_RS03100
uniprot id: A5UKU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

420247:MSM RS04440
gene id: 420247:MSM_RS04440
uniprot id: A5ULL5
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

420247:MSM RS08125
gene id: 420247:MSM_RS08125
uniprot id: A5UNP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

420247:MSM RS05445
gene id: 420247:MSM_RS05445
uniprot id: A5UM61
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

420247:MSM RS02320
gene id: 420247:MSM_RS02320
uniprot id: A5UKE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

420247:MSM RS03530
gene id: 420247:MSM_RS03530
uniprot id: A5UL33
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

420247:MSM RS04290
gene id: 420247:MSM_RS04290
uniprot id: A5ULI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

420247:MSM RS02955
gene id: 420247:MSM_RS02955
uniprot id: A5UKR6
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS05750
gene id: 420247:MSM_RS05750
uniprot id: A5UMB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

420247:MSM RS05250
gene id: 420247:MSM_RS05250
uniprot id: A5UM20
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

420247:MSM RS01940
gene id: 420247:MSM_RS01940
uniprot id: A5UK69
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

420247:MSM RS02325
gene id: 420247:MSM_RS02325
uniprot id: A5UKE7
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS03915
gene id: 420247:MSM_RS03915
uniprot id: A5ULB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

420247:MSM RS06415
gene id: 420247:MSM_RS06415
uniprot id: A5UMP7
names: Subunit
messages: Homotetramer.

420247:MSM RS02175
gene id: 420247:MSM_RS02175
uniprot id: A5UKB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

420247:MSM RS05485
gene id: 420247:MSM_RS05485
uniprot id: A5UM69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

420247:MSM RS02235
gene id: 420247:MSM_RS02235
uniprot id: A5UKC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

420247:MSM RS00485
gene id: 420247:MSM_RS00485
uniprot id: A5UJC8
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

420247:MSM RS03460
gene id: 420247:MSM_RS03460
uniprot id: A5UL18
names: Similarity
messages: Belongs to the Nudix hydrolase family.

420247:MSM RS07695
gene id: 420247:MSM_RS07695
uniprot id: A5UNG3
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

420247:MSM RS04685
gene id: 420247:MSM_RS04685
uniprot id: A5ULQ7
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

420247:MSM RS06845
gene id: 420247:MSM_RS06845
uniprot id: A5UMY5
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

420247:MSM RS07275
gene id: 420247:MSM_RS07275
uniprot id: A5UN73
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

420247:MSM RS07185
gene id: 420247:MSM_RS07185
uniprot id: A5UN54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

420247:MSM RS05180
gene id: 420247:MSM_RS05180
uniprot id: A5UM06
names: Similarity
messages: Belongs to the UPF0045 family.

420247:MSM RS00315
gene id: 420247:MSM_RS00315
uniprot id: A5UJ93
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS00285
gene id: 420247:MSM_RS00285
uniprot id: A5UJ87
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

420247:MSM RS00995
gene id: 420247:MSM_RS00995
uniprot id: A5UJN1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

420247:MSM RS07410
gene id: 420247:MSM_RS07410
uniprot id: A5UNA1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Reduced FMN (FMNH(2)).

420247:MSM RS05170
gene id: 420247:MSM_RS05170
uniprot id: A5UM04
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS02165
gene id: 420247:MSM_RS02165
uniprot id: A5UKB5
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

420247:MSM RS04525
gene id: 420247:MSM_RS04525
uniprot id: A5ULN0
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

420247:MSM RS03590
gene id: 420247:MSM_RS03590
uniprot id: A5UL47
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

420247:MSM RS02220
gene id: 420247:MSM_RS02220
uniprot id: A5UKC6
names: Similarity
messages: Belongs to the PrpD family.

420247:MSM RS01815
gene id: 420247:MSM_RS01815
uniprot id: A5UK44
names: Similarity
messages: Belongs to the UPF0305 family.

420247:MSM RS07430
gene id: 420247:MSM_RS07430
uniprot id: A5UNA5
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Tetramer of two alpha and two beta subunits.

420247:MSM RS01285
gene id: 420247:MSM_RS01285
uniprot id: A5UJU1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: In Archaea the pyridoxal phosphate cofactor is not covalently bound to Lys but ligated by other amino acids.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

420247:MSM RS03755
gene id: 420247:MSM_RS03755
uniprot id: A5UL79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

420247:MSM RS05375
gene id: 420247:MSM_RS05375
uniprot id: A5UM45
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

420247:MSM RS03230
gene id: 420247:MSM_RS03230
uniprot id: A5UKX2
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

420247:MSM RS03715
gene id: 420247:MSM_RS03715
uniprot id: A5UL71
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

420247:MSM RS03135
gene id: 420247:MSM_RS03135
uniprot id: A5UKV4
names: Similarity
messages: Belongs to the MtrH family.

420247:MSM RS07250
gene id: 420247:MSM_RS07250
uniprot id: A5UN68
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

420247:MSM RS03745
gene id: 420247:MSM_RS03745
uniprot id: A5UL77
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

420247:MSM RS06605
gene id: 420247:MSM_RS06605
uniprot id: A5UMT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

420247:MSM RS07165
gene id: 420247:MSM_RS07165
uniprot id: A5UN51
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

420247:MSM RS03765
gene id: 420247:MSM_RS03765
uniprot id: A5UL81
names: Similarity
messages: Belongs to the SUI1 family.

420247:MSM RS03885
gene id: 420247:MSM_RS03885
uniprot id: A5ULA5
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

420247:MSM RS08510
gene id: 420247:MSM_RS08510
uniprot id: A5UNX8
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

420247:MSM RS06955
gene id: 420247:MSM_RS06955
uniprot id: A5UN09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

420247:MSM RS04740
gene id: 420247:MSM_RS04740
uniprot id: A5ULR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

420247:MSM RS03515
gene id: 420247:MSM_RS03515
uniprot id: A5UL30
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

420247:MSM RS05115
gene id: 420247:MSM_RS05115
uniprot id: A5ULZ3
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

420247:MSM RS00275
gene id: 420247:MSM_RS00275
uniprot id: A5UJ85
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

420247:MSM RS03795
gene id: 420247:MSM_RS03795
uniprot id: A5UL87
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

420247:MSM RS01305
gene id: 420247:MSM_RS01305
uniprot id: A5UJU5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

420247:MSM RS06555
gene id: 420247:MSM_RS06555
uniprot id: A5UMS5
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

420247:MSM RS00910
gene id: 420247:MSM_RS00910
uniprot id: A5UJL4
names: Function
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

420247:MSM RS05840
gene id: 420247:MSM_RS05840
uniprot id: A5UMD2
names: Similarity
messages: Belongs to the UPF0107 family.

420247:MSM RS04745
gene id: 420247:MSM_RS04745
uniprot id: A5ULR9
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS04975
gene id: 420247:MSM_RS04975
uniprot id: A5ULW5
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

420247:MSM RS07245
gene id: 420247:MSM_RS07245
uniprot id: A5UN67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

420247:MSM RS05960
gene id: 420247:MSM_RS05960
uniprot id: A5UMF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

420247:MSM RS00615
gene id: 420247:MSM_RS00615
uniprot id: A5UJF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm

420247:MSM RS05265
gene id: 420247:MSM_RS05265
uniprot id: A5UM23
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

420247:MSM RS02510
gene id: 420247:MSM_RS02510
uniprot id: A5UKI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

420247:MSM RS05410
gene id: 420247:MSM_RS05410
uniprot id: A5UM52
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

420247:MSM RS02525
gene id: 420247:MSM_RS02525
uniprot id: A5UKI8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

420247:MSM RS02210
gene id: 420247:MSM_RS02210
uniprot id: A5UKC4
names: Similarity
messages: Belongs to the class-I fumarase family.

420247:MSM RS06835
gene id: 420247:MSM_RS06835
uniprot id: A5UMY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

420247:MSM RS01530
gene id: 420247:MSM_RS01530
uniprot id: A5UJY9
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

420247:MSM RS04960
gene id: 420247:MSM_RS04960
uniprot id: A5ULW2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

420247:MSM RS06090
gene id: 420247:MSM_RS06090
uniprot id: A5UMI1
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

420247:MSM RS07760
gene id: 420247:MSM_RS07760
uniprot id: A5UNH7
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

420247:MSM RS03505
gene id: 420247:MSM_RS03505
uniprot id: A5UL28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

420247:MSM RS03075
gene id: 420247:MSM_RS03075
uniprot id: A5UKU2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

420247:MSM RS07925
gene id: 420247:MSM_RS07925
uniprot id: A5UNK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

420247:MSM RS01155
gene id: 420247:MSM_RS01155
uniprot id: A5UJR5
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.

420247:MSM RS05040
gene id: 420247:MSM_RS05040
uniprot id: A5ULX8
names: Similarity
messages: Belongs to the MvhD/VhuD family.

420247:MSM RS04865
gene id: 420247:MSM_RS04865
uniprot id: A5ULU3
names: Similarity
messages: Belongs to the AAA ATPase family.

420247:MSM RS04095
gene id: 420247:MSM_RS04095
uniprot id: A5ULE8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

420247:MSM RS01875
gene id: 420247:MSM_RS01875
uniprot id: A5UK56
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

420247:MSM RS07745
gene id: 420247:MSM_RS07745
uniprot id: A5UNH4
names: Similarity
messages: Belongs to the SAICAR synthetase family.

420247:MSM RS07175
gene id: 420247:MSM_RS07175
uniprot id: A5UN52
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

420247:MSM RS05395
gene id: 420247:MSM_RS05395
uniprot id: A5UM49
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS02860
gene id: 420247:MSM_RS02860
uniprot id: A5UKP9
names: Function
names: Similarity
messages: Belongs to the HMD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

420247:MSM RS02310
gene id: 420247:MSM_RS02310
uniprot id: A5UKE4
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.

420247:MSM RS07050
gene id: 420247:MSM_RS07050
uniprot id: A5UN28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

420247:MSM RS00845
gene id: 420247:MSM_RS00845
uniprot id: A5UJK1
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

420247:MSM RS03225
gene id: 420247:MSM_RS03225
uniprot id: A5UKX1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

420247:MSM RS04900
gene id: 420247:MSM_RS04900
uniprot id: A5ULV0
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

420247:MSM RS05555
gene id: 420247:MSM_RS05555
uniprot id: A5UM78
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

420247:MSM RS05735
gene id: 420247:MSM_RS05735
uniprot id: A5UMB1
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

420247:MSM RS04715
gene id: 420247:MSM_RS04715
uniprot id: A5ULR3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

420247:MSM RS01170
gene id: 420247:MSM_RS01170
uniprot id: A5UJR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

420247:MSM RS03585
gene id: 420247:MSM_RS03585
uniprot id: A5UL46
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

420247:MSM RS04350
gene id: 420247:MSM_RS04350
uniprot id: A5ULJ7
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

420247:MSM RS05925
gene id: 420247:MSM_RS05925
uniprot id: A5UME9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

420247:MSM RS01970
gene id: 420247:MSM_RS01970
uniprot id: A5UK75
names: Similarity
messages: Belongs to the UPRTase family.

420247:MSM RS01935
gene id: 420247:MSM_RS01935
uniprot id: A5UK68
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

420247:MSM RS04300
gene id: 420247:MSM_RS04300
uniprot id: A5ULI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

420247:MSM RS01995
gene id: 420247:MSM_RS01995
uniprot id: A5UK80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

420247:MSM RS00375
gene id: 420247:MSM_RS00375
uniprot id: A5UJA6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

420247:MSM RS02710
gene id: 420247:MSM_RS02710
uniprot id: A5UKL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

420247:MSM RS01195
gene id: 420247:MSM_RS01195
uniprot id: A5UJS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

420247:MSM RS02290
gene id: 420247:MSM_RS02290
uniprot id: A5UKE0
names: Similarity
messages: Belongs to the tRNA(His) guanylyltransferase family.

420247:MSM RS08110
gene id: 420247:MSM_RS08110
uniprot id: A5UNP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

420247:MSM RS02070
gene id: 420247:MSM_RS02070
uniprot id: A5UK95
names: Similarity
messages: Belongs to the UPF0145 family.

420247:MSM RS03800
gene id: 420247:MSM_RS03800
uniprot id: A5UL88
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

420247:MSM RS02425
gene id: 420247:MSM_RS02425
uniprot id: A5UKG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

420247:MSM RS06870
gene id: 420247:MSM_RS06870
uniprot id: A5UMZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

420247:MSM RS08190
gene id: 420247:MSM_RS08190
uniprot id: A5UNR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

420247:MSM RS00460
gene id: 420247:MSM_RS00460
uniprot id: A5UJC3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

420247:MSM RS08120
gene id: 420247:MSM_RS08120
uniprot id: A5UNP7
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS08945
gene id: 420247:MSM_RS08945
uniprot id: A5UP69
names: Similarity
messages: Belongs to the NAPRTase family.

420247:MSM RS00435
gene id: 420247:MSM_RS00435
uniprot id: A5UJB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclic 2,3-diphosphoglycerate synthetase family.
messages: Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP.
messages: Cytoplasm

420247:MSM RS03750
gene id: 420247:MSM_RS03750
uniprot id: A5UL78
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

420247:MSM RS04120
gene id: 420247:MSM_RS04120
uniprot id: A5ULF3
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

420247:MSM RS02170
gene id: 420247:MSM_RS02170
uniprot id: A5UKB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane

420247:MSM RS07260
gene id: 420247:MSM_RS07260
uniprot id: A5UN70
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

420247:MSM RS05565
gene id: 420247:MSM_RS05565
uniprot id: A5UM80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

420247:MSM RS07350
gene id: 420247:MSM_RS07350
uniprot id: A5UN88
names: Similarity
messages: Belongs to the MvhD/VhuD family.

420247:MSM RS04615
gene id: 420247:MSM_RS04615
uniprot id: A5ULP3
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

420247:MSM RS03785
gene id: 420247:MSM_RS03785
uniprot id: A5UL85
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

420247:MSM RS07915
gene id: 420247:MSM_RS07915
uniprot id: A5UNK6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

420247:MSM RS00390
gene id: 420247:MSM_RS00390
uniprot id: A5UJA9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Belongs to the MvhD/VhuD family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

420247:MSM RS00420
gene id: 420247:MSM_RS00420
uniprot id: A5UJB5
names: Similarity
messages: Belongs to the UPF0280 family.

420247:MSM RS04510
gene id: 420247:MSM_RS04510
uniprot id: A5ULM7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

420247:MSM RS08105
gene id: 420247:MSM_RS08105
uniprot id: A5UNP4
names: Similarity
messages: Belongs to the OMP decarboxylase family.

420247:MSM RS08605
gene id: 420247:MSM_RS08605
uniprot id: A5UNZ8
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS01040
gene id: 420247:MSM_RS01040
uniprot id: A5UJP1
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

420247:MSM RS02880
gene id: 420247:MSM_RS02880
uniprot id: A5UKQ3
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

420247:MSM RS01990
gene id: 420247:MSM_RS01990
uniprot id: A5UK79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

420247:MSM RS03085
gene id: 420247:MSM_RS03085
uniprot id: A5UKU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

420247:MSM RS04795
gene id: 420247:MSM_RS04795
uniprot id: A5ULS9
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

420247:MSM RS07155
gene id: 420247:MSM_RS07155
uniprot id: A5UN49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

420247:MSM RS06140
gene id: 420247:MSM_RS06140
uniprot id: A5UMJ1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.
messages: The N-terminal domain is an archaea-specific tRNA-editing domain that hydrolyzes incorrectly charged L-seryl-tRNA(Thr). Catalysis of tRNA editing is performed by the charged tRNA itself.

420247:MSM RS04870
gene id: 420247:MSM_RS04870
uniprot id: A5ULU4
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

420247:MSM RS07690
gene id: 420247:MSM_RS07690
uniprot id: A5UNG2
names: Similarity
messages: Belongs to the polysaccharide synthase family.

420247:MSM RS06365
gene id: 420247:MSM_RS06365
uniprot id: A5UMN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

420247:MSM RS04020
gene id: 420247:MSM_RS04020
uniprot id: A5ULD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

420247:MSM RS07810
gene id: 420247:MSM_RS07810
uniprot id: A5UNI7
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS03235
gene id: 420247:MSM_RS03235
uniprot id: A5UKX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

420247:MSM RS04500
gene id: 420247:MSM_RS04500
uniprot id: A5ULM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

420247:MSM RS08480
gene id: 420247:MSM_RS08480
uniprot id: A5UNX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

420247:MSM RS05920
gene id: 420247:MSM_RS05920
uniprot id: A5UME8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

420247:MSM RS01480
gene id: 420247:MSM_RS01480
uniprot id: A5UJX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

420247:MSM RS06865
gene id: 420247:MSM_RS06865
uniprot id: A5UMY9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

420247:MSM RS06105
gene id: 420247:MSM_RS06105
uniprot id: A5UMI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ModE family.
messages: Membrane

420247:MSM RS07990
gene id: 420247:MSM_RS07990
uniprot id: A5UNM0
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS00940
gene id: 420247:MSM_RS00940
uniprot id: A5UJM0
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

420247:MSM RS03740
gene id: 420247:MSM_RS03740
uniprot id: A5UL76
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

420247:MSM RS08175
gene id: 420247:MSM_RS08175
uniprot id: A5UNQ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

420247:MSM RS01505
gene id: 420247:MSM_RS01505
uniprot id: A5UJY4
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

420247:MSM RS00975
gene id: 420247:MSM_RS00975
uniprot id: A5UJM7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

420247:MSM RS06110
gene id: 420247:MSM_RS06110
uniprot id: A5UMI5
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS05655
gene id: 420247:MSM_RS05655
uniprot id: A5UM97
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

420247:MSM RS05450
gene id: 420247:MSM_RS05450
uniprot id: A5UM62
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS02120
gene id: 420247:MSM_RS02120
uniprot id: A5UKA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

420247:MSM RS03215
gene id: 420247:MSM_RS03215
uniprot id: A5UKW9
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

420247:MSM RS00525
gene id: 420247:MSM_RS00525
uniprot id: A5UJD5
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

420247:MSM RS06220
gene id: 420247:MSM_RS06220
uniprot id: A5UMK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

420247:MSM RS04555
gene id: 420247:MSM_RS04555
uniprot id: A5ULN6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

420247:MSM RS00585
gene id: 420247:MSM_RS00585
uniprot id: A5UJE7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

420247:MSM RS07825
gene id: 420247:MSM_RS07825
uniprot id: A5UNI8
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

420247:MSM RS04225
gene id: 420247:MSM_RS04225
uniprot id: A5ULH2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

420247:MSM RS08075
gene id: 420247:MSM_RS08075
uniprot id: A5UNN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

420247:MSM RS05475
gene id: 420247:MSM_RS05475
uniprot id: A5UM67
names: Similarity
messages: Belongs to the SfsA family.

420247:MSM RS07530
gene id: 420247:MSM_RS07530
uniprot id: A5UNC5
names: Similarity
messages: Belongs to the DEAD box helicase family.

420247:MSM RS01950
gene id: 420247:MSM_RS01950
uniprot id: A5UK71
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

420247:MSM RS03065
gene id: 420247:MSM_RS03065
uniprot id: A5UKU0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Binds 2 Mg(2+) or Mn(2+) ions per subunit.
messages: Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
messages: Cell membrane

420247:MSM RS05165
gene id: 420247:MSM_RS05165
uniprot id: A5UM03
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS03725
gene id: 420247:MSM_RS03725
uniprot id: A5UL73
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

420247:MSM RS03555
gene id: 420247:MSM_RS03555
uniprot id: A5UL38
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

420247:MSM RS04415
gene id: 420247:MSM_RS04415
uniprot id: A5ULL0
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

420247:MSM RS01475
gene id: 420247:MSM_RS01475
uniprot id: A5UJX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

420247:MSM RS04090
gene id: 420247:MSM_RS04090
uniprot id: A5ULE7
names: Similarity
messages: Belongs to the MoaB/Mog family.

420247:MSM RS04175
gene id: 420247:MSM_RS04175
uniprot id: A5ULG4
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

420247:MSM RS07440
gene id: 420247:MSM_RS07440
uniprot id: A5UNA7
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

420247:MSM RS04010
gene id: 420247:MSM_RS04010
uniprot id: A5ULD1
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

420247:MSM RS00210
gene id: 420247:MSM_RS00210
uniprot id: A5UJ72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

420247:MSM RS01910
gene id: 420247:MSM_RS01910
uniprot id: A5UK63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

420247:MSM RS01000
gene id: 420247:MSM_RS01000
uniprot id: A5UJN2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

420247:MSM RS06100
gene id: 420247:MSM_RS06100
uniprot id: A5UMI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

420247:MSM RS05740
gene id: 420247:MSM_RS05740
uniprot id: A5UMB2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

420247:MSM RS02570
gene id: 420247:MSM_RS02570
uniprot id: A5UKJ7
names: Similarity
messages: Belongs to the thymidylate kinase family.

420247:MSM RS00345
gene id: 420247:MSM_RS00345
uniprot id: A5UJA0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

420247:MSM RS08185
gene id: 420247:MSM_RS08185
uniprot id: A5UNR0
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

420247:MSM RS03055
gene id: 420247:MSM_RS03055
uniprot id: A5UKT8
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

420247:MSM RS06135
gene id: 420247:MSM_RS06135
uniprot id: A5UMJ0
names: Caution
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

420247:MSM RS01165
gene id: 420247:MSM_RS01165
uniprot id: A5UJR7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

420247:MSM RS04055
gene id: 420247:MSM_RS04055
uniprot id: A5ULE0
names: Similarity
messages: Belongs to the UPF0288 family.

420247:MSM RS06990
gene id: 420247:MSM_RS06990
uniprot id: A5UN16
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

420247:MSM RS08130
gene id: 420247:MSM_RS08130
uniprot id: A5UNP9
names: Similarity
messages: Belongs to the DMRL synthase family.

420247:MSM RS05075
gene id: 420247:MSM_RS05075
uniprot id: A5ULY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrG family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

420247:MSM RS07420
gene id: 420247:MSM_RS07420
uniprot id: A5UNA3
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

420247:MSM RS01855
gene id: 420247:MSM_RS01855
uniprot id: A5UK52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

420247:MSM RS04625
gene id: 420247:MSM_RS04625
uniprot id: A5ULP5
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

420247:MSM RS00805
gene id: 420247:MSM_RS00805
uniprot id: A5UJJ3
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

420247:MSM RS05220
gene id: 420247:MSM_RS05220
uniprot id: A5UM14
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

420247:MSM RS01100
gene id: 420247:MSM_RS01100
uniprot id: A5UJQ4
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

420247:MSM RS05675
gene id: 420247:MSM_RS05675
uniprot id: A5UMA1
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

420247:MSM RS06250
gene id: 420247:MSM_RS06250
uniprot id: A5UML4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.

420247:MSM RS04560
gene id: 420247:MSM_RS04560
uniprot id: A5ULN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

420247:MSM RS07380
gene id: 420247:MSM_RS07380
uniprot id: A5UN95
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

420247:MSM RS00355
gene id: 420247:MSM_RS00355
uniprot id: A5UJA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).

420247:MSM RS06385
gene id: 420247:MSM_RS06385
uniprot id: A5UMP1
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

420247:MSM RS03125
gene id: 420247:MSM_RS03125
uniprot id: A5UKV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

420247:MSM RS01190
gene id: 420247:MSM_RS01190
uniprot id: A5UJS2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

420247:MSM RS04655
gene id: 420247:MSM_RS04655
uniprot id: A5ULQ1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

420247:MSM RS05185
gene id: 420247:MSM_RS05185
uniprot id: A5UM07
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

420247:MSM RS04220
gene id: 420247:MSM_RS04220
uniprot id: A5ULH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

420247:MSM RS06335
gene id: 420247:MSM_RS06335
uniprot id: A5UMN1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

420247:MSM RS04970
gene id: 420247:MSM_RS04970
uniprot id: A5ULW4
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.

420247:MSM RS00425
gene id: 420247:MSM_RS00425
uniprot id: A5UJB6
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

420247:MSM RS08095
gene id: 420247:MSM_RS08095
uniprot id: A5UNP2
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

420247:MSM RS04935
gene id: 420247:MSM_RS04935
uniprot id: A5ULV7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

420247:MSM RS08160
gene id: 420247:MSM_RS08160
uniprot id: A5UNQ5
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

420247:MSM RS06825
gene id: 420247:MSM_RS06825
uniprot id: A5UMY1
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

420247:MSM RS06070
gene id: 420247:MSM_RS06070
uniprot id: A5UMH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
messages: Cell membrane

420247:MSM RS05130
gene id: 420247:MSM_RS05130
uniprot id: A5ULZ6
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

420247:MSM RS03525
gene id: 420247:MSM_RS03525
uniprot id: A5UL32
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

420247:MSM RS06840
gene id: 420247:MSM_RS06840
uniprot id: A5UMY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

420247:MSM RS06160
gene id: 420247:MSM_RS06160
uniprot id: A5UMJ5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

420247:MSM RS04385
gene id: 420247:MSM_RS04385
uniprot id: A5ULK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

420247:MSM RS02330
gene id: 420247:MSM_RS02330
uniprot id: A5UKE8
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS03495
gene id: 420247:MSM_RS03495
uniprot id: A5UL26
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS06405
gene id: 420247:MSM_RS06405
uniprot id: A5UMP5
names: Similarity
messages: Belongs to the UPF0147 family.

420247:MSM RS07480
gene id: 420247:MSM_RS07480
uniprot id: A5UNB5
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS03665
gene id: 420247:MSM_RS03665
uniprot id: A5UL61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

420247:MSM RS00815
gene id: 420247:MSM_RS00815
uniprot id: A5UJJ5
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

420247:MSM RS05935
gene id: 420247:MSM_RS05935
uniprot id: A5UMF1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

420247:MSM RS01600
gene id: 420247:MSM_RS01600
uniprot id: A5UK03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EhaA family.
messages: Cell membrane
messages: Membrane
messages: One of the integral membrane subunits of multisubunit membrane-bound [NiFe]-hydrogenase eha. Eha is predicted to form large electron transfer complex and might catalyze energy-driven reduction of low-potential redox carriers.
messages: Putative multisubunit membrane-bound [NiFe]-hydrogenase eha is composed of at least 20 subunits.

420247:MSM RS05795
gene id: 420247:MSM_RS05795
uniprot id: A5UMC3
names: Similarity
messages: Belongs to the anthranilate synthase component I family.

420247:MSM RS03185
gene id: 420247:MSM_RS03185
uniprot id: A5UKW3
names: Similarity
messages: Belongs to the HupF/HypC family.

420247:MSM RS04965
gene id: 420247:MSM_RS04965
uniprot id: A5ULW3
names: Similarity
messages: Belongs to the peptidase C59 family.

420247:MSM RS03625
gene id: 420247:MSM_RS03625
uniprot id: A5UL54
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine.

420247:MSM RS03680
gene id: 420247:MSM_RS03680
uniprot id: A5UL64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

420247:MSM RS06420
gene id: 420247:MSM_RS06420
uniprot id: A5UMP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

420247:MSM RS03605
gene id: 420247:MSM_RS03605
uniprot id: A5UL50
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

420247:MSM RS06190
gene id: 420247:MSM_RS06190
uniprot id: A5UMK2
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

420247:MSM RS05085
gene id: 420247:MSM_RS05085
uniprot id: A5ULY7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

420247:MSM RS07015
gene id: 420247:MSM_RS07015
uniprot id: A5UN21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

420247:MSM RS02520
gene id: 420247:MSM_RS02520
uniprot id: A5UKI7
names: Similarity
messages: Belongs to the MCM family.

420247:MSM RS03775
gene id: 420247:MSM_RS03775
uniprot id: A5UL83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

420247:MSM RS04980
gene id: 420247:MSM_RS04980
uniprot id: A5ULW6
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

420247:MSM RS05595
gene id: 420247:MSM_RS05595
uniprot id: A5UM86
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

420247:MSM RS02935
gene id: 420247:MSM_RS02935
uniprot id: A5UKR2
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS04180
gene id: 420247:MSM_RS04180
uniprot id: A5ULG5
names: Similarity
messages: Belongs to the glutaredoxin family.

420247:MSM RS06195
gene id: 420247:MSM_RS06195
uniprot id: A5UMK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.

420247:MSM RS06020
gene id: 420247:MSM_RS06020
uniprot id: A5UMG8
names: Subcellular Location Annotation
messages: Cytoplasm

420247:MSM RS05100
gene id: 420247:MSM_RS05100
uniprot id: A5ULZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

420247:MSM RS00790
gene id: 420247:MSM_RS00790
uniprot id: A5UJJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

420247:MSM RS03510
gene id: 420247:MSM_RS03510
uniprot id: A5UL29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

420247:MSM RS04680
gene id: 420247:MSM_RS04680
uniprot id: A5ULQ6
names: Similarity
messages: Belongs to the class-I fumarase family.

420247:MSM RS04515
gene id: 420247:MSM_RS04515
uniprot id: A5ULM8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

420247:MSM RS05030
gene id: 420247:MSM_RS05030
uniprot id: A5ULX6
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

420247:MSM RS03655
gene id: 420247:MSM_RS03655
uniprot id: A5UL59
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

420247:MSM RS03600
gene id: 420247:MSM_RS03600
uniprot id: A5UL49
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

420247:MSM RS07435
gene id: 420247:MSM_RS07435
uniprot id: A5UNA6
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

420247:MSM RS07105
gene id: 420247:MSM_RS07105
uniprot id: A5UN39
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

420247:MSM RS07305
gene id: 420247:MSM_RS07305
uniprot id: A5UN79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

420247:MSM RS04405
gene id: 420247:MSM_RS04405
uniprot id: A5ULK8
names: Similarity
messages: Belongs to the HMBS family.

420247:MSM RS06985
gene id: 420247:MSM_RS06985
uniprot id: A5UN15
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

420247:MSM RS05600
gene id: 420247:MSM_RS05600
uniprot id: A5UM87
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

420247:MSM RS05310
gene id: 420247:MSM_RS05310
uniprot id: A5UM32
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

420247:MSM RS03565
gene id: 420247:MSM_RS03565
uniprot id: A5UL40
names: Caution
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

420247:MSM RS07180
gene id: 420247:MSM_RS07180
uniprot id: A5UN53
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

420247:MSM RS00640
gene id: 420247:MSM_RS00640
uniprot id: A5UJF8
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS03780
gene id: 420247:MSM_RS03780
uniprot id: A5UL84
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

420247:MSM RS02820
gene id: 420247:MSM_RS02820
uniprot id: A5UKP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

420247:MSM RS02140
gene id: 420247:MSM_RS02140
uniprot id: A5UKB0
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

420247:MSM RS03670
gene id: 420247:MSM_RS03670
uniprot id: A5UL62
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

420247:MSM RS04370
gene id: 420247:MSM_RS04370
uniprot id: A5ULK1
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

420247:MSM RS06690
gene id: 420247:MSM_RS06690
uniprot id: A5UMV2
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS03970
gene id: 420247:MSM_RS03970
uniprot id: A5ULC2
names: Function
names: Similarity
messages: Belongs to the HdrB family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).

420247:MSM RS02145
gene id: 420247:MSM_RS02145
uniprot id: A5UKB1
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

420247:MSM RS00455
gene id: 420247:MSM_RS00455
uniprot id: A5UJC2
names: Similarity
messages: Belongs to the MtxX family.

420247:MSM RS03245
gene id: 420247:MSM_RS03245
uniprot id: A5UKX5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

420247:MSM RS05785
gene id: 420247:MSM_RS05785
uniprot id: A5UMC1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

420247:MSM RS03790
gene id: 420247:MSM_RS03790
uniprot id: A5UL86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

420247:MSM RS07675
gene id: 420247:MSM_RS07675
uniprot id: A5UNF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

420247:MSM RS03840
gene id: 420247:MSM_RS03840
uniprot id: A5UL96
names: Similarity
messages: Belongs to the class-I fumarase family.

420247:MSM RS05760
gene id: 420247:MSM_RS05760
uniprot id: A5UMB6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MurCDEF family. MurT subfamily.
messages: Forms a heterodimer with GatD.
messages: The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.

420247:MSM RS05970
gene id: 420247:MSM_RS05970
uniprot id: A5UMF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

420247:MSM RS01390
gene id: 420247:MSM_RS01390
uniprot id: A5UJW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

420247:MSM RS04550
gene id: 420247:MSM_RS04550
uniprot id: A5ULN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

420247:MSM RS04620
gene id: 420247:MSM_RS04620
uniprot id: A5ULP4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

420247:MSM RS06095
gene id: 420247:MSM_RS06095
uniprot id: A5UMI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

420247:MSM RS05950
gene id: 420247:MSM_RS05950
uniprot id: A5UMF4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

420247:MSM RS03865
gene id: 420247:MSM_RS03865
uniprot id: A5ULA1
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS05590
gene id: 420247:MSM_RS05590
uniprot id: A5UM85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

420247:MSM RS04760
gene id: 420247:MSM_RS04760
uniprot id: A5ULS2
names: Similarity
messages: Belongs to the HypD family.

420247:MSM RS06440
gene id: 420247:MSM_RS06440
uniprot id: A5UMQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

420247:MSM RS04925
gene id: 420247:MSM_RS04925
uniprot id: A5ULV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

420247:MSM RS06295
gene id: 420247:MSM_RS06295
uniprot id: A5UMM3
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Homodimer.

420247:MSM RS01410
gene id: 420247:MSM_RS01410
uniprot id: A5UJW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

420247:MSM RS03760
gene id: 420247:MSM_RS03760
uniprot id: A5UL80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

420247:MSM RS07000
gene id: 420247:MSM_RS07000
uniprot id: A5UN18
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

420247:MSM RS03695
gene id: 420247:MSM_RS03695
uniprot id: A5UL67
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

420247:MSM RS00630
gene id: 420247:MSM_RS00630
uniprot id: A5UJF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

420247:MSM RS04330
gene id: 420247:MSM_RS04330
uniprot id: A5ULJ3
names: Similarity
messages: Belongs to the peptidase U62 family.

420247:MSM RS06915
gene id: 420247:MSM_RS06915
uniprot id: A5UMZ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

420247:MSM RS04140
gene id: 420247:MSM_RS04140
uniprot id: A5ULF7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

420247:MSM RS03440
gene id: 420247:MSM_RS03440
uniprot id: A5UL13
names: Similarity
messages: Belongs to the TPP enzyme family.

420247:MSM RS02455
gene id: 420247:MSM_RS02455
uniprot id: A5UKH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

420247:MSM RS07235
gene id: 420247:MSM_RS07235
uniprot id: A5UN65
names: Similarity
messages: Belongs to the MEMO1 family.

420247:MSM RS01700
gene id: 420247:MSM_RS01700
uniprot id: A5UK23
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

420247:MSM RS02920
gene id: 420247:MSM_RS02920
uniprot id: A5UKQ9
names: Caution
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

420247:MSM RS06545
gene id: 420247:MSM_RS06545
uniprot id: A5UMS3
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

420247:MSM RS05190
gene id: 420247:MSM_RS05190
uniprot id: A5UM08
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

420247:MSM RS04250
gene id: 420247:MSM_RS04250
uniprot id: A5ULH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

420247:MSM RS05480
gene id: 420247:MSM_RS05480
uniprot id: A5UM68
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

420247:MSM RS07985
gene id: 420247:MSM_RS07985
uniprot id: A5UNL9
names: Similarity
messages: Belongs to the ABC transporter superfamily.

420247:MSM RS06745
gene id: 420247:MSM_RS06745
uniprot id: A5UMW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

420247:MSM RS07205
gene id: 420247:MSM_RS07205
uniprot id: A5UN58
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

420247:MSM RS05945
gene id: 420247:MSM_RS05945
uniprot id: A5UMF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

420247:MSM RS01835
gene id: 420247:MSM_RS01835
uniprot id: A5UK48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

420247:MSM RS02150
gene id: 420247:MSM_RS02150
uniprot id: A5UKB2
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

420247:MSM RS04815
gene id: 420247:MSM_RS04815
uniprot id: A5ULT3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

420247:MSM RS04845
gene id: 420247:MSM_RS04845
uniprot id: A5ULT9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

420247:MSM RS01685
gene id: 420247:MSM_RS01685
uniprot id: A5UK20
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

420247:MSM RS00125
gene id: 420247:MSM_RS00125
uniprot id: A5UJ54
names: Similarity
messages: Belongs to the glutamate synthase family.

420247:MSM RS03340
gene id: 420247:MSM_RS03340
uniprot id: A5UKZ3
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

420247:MSM RS08195
gene id: 420247:MSM_RS08195
uniprot id: A5UNR2
names: Similarity
messages: Belongs to the UPF0440 family.

420247:MSM RS06730
gene id: 420247:MSM_RS06730
uniprot id: A5UMW0
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

420247:MSM RS07470
gene id: 420247:MSM_RS07470
uniprot id: A5UNB3
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

420247:MSM RS00335
gene id: 420247:MSM_RS00335
uniprot id: A5UJ98
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

420247:MSM RS07255
gene id: 420247:MSM_RS07255
uniprot id: A5UN69
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

420247:MSM RS08170
gene id: 420247:MSM_RS08170
uniprot id: A5UNQ7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.
messages: Binds 1 zinc ion per subunit.

420247:MSM RS04395
gene id: 420247:MSM_RS04395
uniprot id: A5ULK6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

420247:MSM RS02255
gene id: 420247:MSM_RS02255
uniprot id: A5UKD3
names: Similarity
messages: Belongs to the UPF0145 family.

420247:MSM RS00795
gene id: 420247:MSM_RS00795
uniprot id: A5UJJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

420247:MSM RS03730
gene id: 420247:MSM_RS03730
uniprot id: A5UL74
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

420247:MSM RS04570
gene id: 420247:MSM_RS04570
uniprot id: A5ULN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

420247:MSM RS03130
gene id: 420247:MSM_RS03130
uniprot id: A5UKV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

420247:MSM RS04280
gene id: 420247:MSM_RS04280
uniprot id: A5ULI3
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS05580
gene id: 420247:MSM_RS05580
uniprot id: A5UM83
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

420247:MSM RS06305
gene id: 420247:MSM_RS06305
uniprot id: A5UMM5
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS07500
gene id: 420247:MSM_RS07500
uniprot id: A5UNB9
names: Similarity
messages: Belongs to the HypE family.

420247:MSM RS05865
gene id: 420247:MSM_RS05865
uniprot id: A5UMD6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

420247:MSM RS03545
gene id: 420247:MSM_RS03545
uniprot id: A5UL36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

420247:MSM RS00725
gene id: 420247:MSM_RS00725
uniprot id: A5UJH4
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

420247:MSM RS00750
gene id: 420247:MSM_RS00750
uniprot id: A5UJI0
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

420247:MSM RS00800
gene id: 420247:MSM_RS00800
uniprot id: A5UJJ2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

420247:MSM RS03995
gene id: 420247:MSM_RS03995
uniprot id: A5ULC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

420247:MSM RS02315
gene id: 420247:MSM_RS02315
uniprot id: A5UKE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

420247:MSM RS01005
gene id: 420247:MSM_RS01005
uniprot id: A5UJN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

420247:MSM RS05255
gene id: 420247:MSM_RS05255
uniprot id: A5UM21
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

420247:MSM RS05020
gene id: 420247:MSM_RS05020
uniprot id: A5ULX4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

420247:MSM RS02505
gene id: 420247:MSM_RS02505
uniprot id: A5UKI4
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

420247:MSM RS00850
gene id: 420247:MSM_RS00850
uniprot id: A5UJK2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

420247:MSM RS02005
gene id: 420247:MSM_RS02005
uniprot id: A5UK82
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

420247:MSM RS08600
gene id: 420247:MSM_RS08600
uniprot id: A5UNZ7
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

420247:MSM RS05415
gene id: 420247:MSM_RS05415
uniprot id: A5UM53
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

420247:MSM RS06895
gene id: 420247:MSM_RS06895
uniprot id: A5UMZ5
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

420247:MSM RS06350
gene id: 420247:MSM_RS06350
uniprot id: A5UMN4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).

420247:MSM RS01445
gene id: 420247:MSM_RS01445
uniprot id: A5UJX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

420247:MSM RS02865
gene id: 420247:MSM_RS02865
uniprot id: A5UKQ0
names: Cofactor
names: Similarity
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

420247:MSM RS00825
gene id: 420247:MSM_RS00825
uniprot id: A5UJJ7
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

420247:MSM RS04765
gene id: 420247:MSM_RS04765
uniprot id: A5ULS3
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

420247:MSM RS08615
gene id: 420247:MSM_RS08615
uniprot id: A5UP00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

420247:MSM RS06510
gene id: 420247:MSM_RS06510
uniprot id: A5UMR6
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS04520
gene id: 420247:MSM_RS04520
uniprot id: A5ULM9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

420247:MSM RS04905
gene id: 420247:MSM_RS04905
uniprot id: A5ULV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.

420247:MSM RS04695
gene id: 420247:MSM_RS04695
uniprot id: A5ULQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

420247:MSM RS03690
gene id: 420247:MSM_RS03690
uniprot id: A5UL66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

420247:MSM RS04145
gene id: 420247:MSM_RS04145
uniprot id: A5ULF8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

420247:MSM RS04390
gene id: 420247:MSM_RS04390
uniprot id: A5ULK5
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

420247:MSM RS04380
gene id: 420247:MSM_RS04380
uniprot id: A5ULK3
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

420247:MSM RS05095
gene id: 420247:MSM_RS05095
uniprot id: A5ULY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

420247:MSM RS00260
gene id: 420247:MSM_RS00260
uniprot id: A5UJ82
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

420247:MSM RS06720
gene id: 420247:MSM_RS06720
uniprot id: A5UMV8
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS08590
gene id: 420247:MSM_RS08590
uniprot id: A5UNZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

420247:MSM RS02430
gene id: 420247:MSM_RS02430
uniprot id: A5UKG9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

420247:MSM RS07230
gene id: 420247:MSM_RS07230
uniprot id: A5UN64
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

420247:MSM RS00305
gene id: 420247:MSM_RS00305
uniprot id: A5UJ91
names: Similarity
messages: Belongs to the UPF0305 family.

420247:MSM RS06345
gene id: 420247:MSM_RS06345
uniprot id: A5UMN3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

420247:MSM RS00710
gene id: 420247:MSM_RS00710
uniprot id: A5UJH2
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS05090
gene id: 420247:MSM_RS05090
uniprot id: A5ULY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

420247:MSM RS05500
gene id: 420247:MSM_RS05500
uniprot id: A5UM72
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS01645
gene id: 420247:MSM_RS01645
uniprot id: A5UK12
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

420247:MSM RS03370
gene id: 420247:MSM_RS03370
uniprot id: A5UKZ9
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

420247:MSM RS02790
gene id: 420247:MSM_RS02790
uniprot id: A5UKN5
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

420247:MSM RS00550
gene id: 420247:MSM_RS00550
uniprot id: A5UJE0
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

420247:MSM RS08055
gene id: 420247:MSM_RS08055
uniprot id: A5UNN3
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

420247:MSM RS07845
gene id: 420247:MSM_RS07845
uniprot id: A5UNJ2
names: Caution
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

420247:MSM RS01345
gene id: 420247:MSM_RS01345
uniprot id: A5UJV2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

420247:MSM RS05515
gene id: 420247:MSM_RS05515
uniprot id: A5UM75
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

420247:MSM RS07905
gene id: 420247:MSM_RS07905
uniprot id: A5UNK4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

420247:MSM RS06875
gene id: 420247:MSM_RS06875
uniprot id: A5UMZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

420247:MSM RS03155
gene id: 420247:MSM_RS03155
uniprot id: A5UKV8
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

420247:MSM RS01355
gene id: 420247:MSM_RS01355
uniprot id: A5UJV4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

420247:MSM RS07210
gene id: 420247:MSM_RS07210
uniprot id: A5UN59
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

420247:MSM RS05820
gene id: 420247:MSM_RS05820
uniprot id: A5UMC8
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

420247:MSM RS04735
gene id: 420247:MSM_RS04735
uniprot id: A5ULR7
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

420247:MSM RS06480
gene id: 420247:MSM_RS06480
uniprot id: A5UMR0
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

420247:MSM RS03105
gene id: 420247:MSM_RS03105
uniprot id: A5UKU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

420247:MSM RS06600
gene id: 420247:MSM_RS06600
uniprot id: A5UMT4
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.

420247:MSM RS00885
gene id: 420247:MSM_RS00885
uniprot id: A5UJK9
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

420247:MSM RS03540
gene id: 420247:MSM_RS03540
uniprot id: A5UL35
names: Similarity
messages: Belongs to the PDCD5 family.

420247:MSM RS02295
gene id: 420247:MSM_RS02295
uniprot id: A5UKE1
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

420247:MSM RS03935
gene id: 420247:MSM_RS03935
uniprot id: A5ULB6
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS05845
gene id: 420247:MSM_RS05845
uniprot id: A5UMD3
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

420247:MSM RS04495
gene id: 420247:MSM_RS04495
uniprot id: A5ULM4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

420247:MSM RS02835
gene id: 420247:MSM_RS02835
uniprot id: A5UKP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Membrane

420247:MSM RS03675
gene id: 420247:MSM_RS03675
uniprot id: A5UL63
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS04185
gene id: 420247:MSM_RS04185
uniprot id: A5ULG6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

420247:MSM RS07545
gene id: 420247:MSM_RS07545
uniprot id: A5UNC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

420247:MSM RS06245
gene id: 420247:MSM_RS06245
uniprot id: A5UML3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

420247:MSM RS06565
gene id: 420247:MSM_RS06565
uniprot id: A5UMS7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

420247:MSM RS00310
gene id: 420247:MSM_RS00310
uniprot id: A5UJ92
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

420247:MSM RS01320
gene id: 420247:MSM_RS01320
uniprot id: A5UJU7
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

420247:MSM RS01060
gene id: 420247:MSM_RS01060
uniprot id: A5UJP5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

420247:MSM RS03950
gene id: 420247:MSM_RS03950
uniprot id: A5ULB8
names: Function
names: Similarity
messages: Belongs to the 2-phosphoglycerate kinase family.
messages: Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant.

420247:MSM RS00990
gene id: 420247:MSM_RS00990
uniprot id: A5UJN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

420247:MSM RS01555
gene id: 420247:MSM_RS01555
uniprot id: A5UJZ4
names: Subcellular Location Annotation
messages: Membrane

420247:MSM RS06180
gene id: 420247:MSM_RS06180
uniprot id: A5UMK0
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

420247:MSM RS03845
gene id: 420247:MSM_RS03845
uniprot id: A5UL97
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

420247:MSM RS02260
gene id: 420247:MSM_RS02260
uniprot id: A5UKD4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

420247:MSM RS05070
gene id: 420247:MSM_RS05070
uniprot id: A5ULY4
names: Similarity
messages: Belongs to the MtrH family.

420247:MSM RS04235
gene id: 420247:MSM_RS04235
uniprot id: A5ULH4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Heterotetramer of 2 HacA and 2 HacB proteins.
messages: Hydro-lyase with broad substrate specificity for cis-unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4-tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4-tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B.

420247:MSM RS08680
gene id: 420247:MSM_RS08680
uniprot id: A5UP13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

420247:MSM RS01275
gene id: 420247:MSM_RS01275
uniprot id: A5UJT9
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

420247:MSM RS01640
gene id: 420247:MSM_RS01640
uniprot id: A5UK11
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

420247:MSM RS01290
gene id: 420247:MSM_RS01290
uniprot id: A5UJU2
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

420247:MSM RS05235
gene id: 420247:MSM_RS05235
uniprot id: A5UM17
names: Similarity
messages: Belongs to the LDH2/MDH2 oxidoreductase family.

420247:MSM RS01325
gene id: 420247:MSM_RS01325
uniprot id: A5UJU8
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

420247:MSM RS05460
gene id: 420247:MSM_RS05460
uniprot id: A5UM64
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class U subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.

420247:MSM RS06230
gene id: 420247:MSM_RS06230
uniprot id: A5UML0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

420247:MSM RS05215
gene id: 420247:MSM_RS05215
uniprot id: A5UM13
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

420247:MSM RS08040
gene id: 420247:MSM_RS08040
uniprot id: A5UNN0
names: Similarity
messages: Belongs to the UPF0235 family.