419665:MAEO RS02210
gene id: 419665:MAEO_RS02210
uniprot id: A6UU57
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

419665:MAEO RS05305
gene id: 419665:MAEO_RS05305
uniprot id: A6UVV8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

419665:MAEO RS01535
gene id: 419665:MAEO_RS01535
uniprot id: A6UTS4
names: Function
names: Similarity
messages: Belongs to the HdrB family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).

419665:MAEO RS07350
gene id: 419665:MAEO_RS07350
uniprot id: A6UWY8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-108 inactivates the nitrogenase reductase and regulates nitrogenase activity.

419665:MAEO RS03945
gene id: 419665:MAEO_RS03945
uniprot id: A6UV49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

419665:MAEO RS04235
gene id: 419665:MAEO_RS04235
uniprot id: A6UVA1
names: Similarity
messages: Belongs to the UPF0235 family.

419665:MAEO RS06825
gene id: 419665:MAEO_RS06825
uniprot id: A6UWN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

419665:MAEO RS00380
gene id: 419665:MAEO_RS00380
uniprot id: A6UT45
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

419665:MAEO RS00635
gene id: 419665:MAEO_RS00635
uniprot id: A6UT96
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

419665:MAEO RS00120
gene id: 419665:MAEO_RS00120
uniprot id: A6USZ5
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

419665:MAEO RS07165
gene id: 419665:MAEO_RS07165
uniprot id: A6UWV0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

419665:MAEO RS06505
gene id: 419665:MAEO_RS06505
uniprot id: A6UWI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MtrH family.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

419665:MAEO RS05760
gene id: 419665:MAEO_RS05760
uniprot id: A6UW46
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

419665:MAEO RS00500
gene id: 419665:MAEO_RS00500
uniprot id: A6UT69
names: Similarity
messages: Belongs to the MvhD/VhuD family.

419665:MAEO RS01420
gene id: 419665:MAEO_RS01420
uniprot id: A6UTQ1
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

419665:MAEO RS07265
gene id: 419665:MAEO_RS07265
uniprot id: A6UWX0
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

419665:MAEO RS04645
gene id: 419665:MAEO_RS04645
uniprot id: A6UVI3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

419665:MAEO RS04015
gene id: 419665:MAEO_RS04015
uniprot id: A6UV63
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.

419665:MAEO RS00930
gene id: 419665:MAEO_RS00930
uniprot id: A6UTF5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

419665:MAEO RS05115
gene id: 419665:MAEO_RS05115
uniprot id: A6UVS1
names: Similarity
messages: Belongs to the LDH2/MDH2 oxidoreductase family.

419665:MAEO RS00575
gene id: 419665:MAEO_RS00575
uniprot id: A6UT84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

419665:MAEO RS06610
gene id: 419665:MAEO_RS06610
uniprot id: A6UWK1
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS01070
gene id: 419665:MAEO_RS01070
uniprot id: A6UTI3
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

419665:MAEO RS05645
gene id: 419665:MAEO_RS05645
uniprot id: A6UW24
names: Similarity
messages: Belongs to the TrpF family.

419665:MAEO RS07540
gene id: 419665:MAEO_RS07540
uniprot id: A6UX26
names: Similarity
messages: Belongs to the DtxR/MntR family.

419665:MAEO RS07230
gene id: 419665:MAEO_RS07230
uniprot id: A6UWW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

419665:MAEO RS01425
gene id: 419665:MAEO_RS01425
uniprot id: A6UTQ2
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

419665:MAEO RS06630
gene id: 419665:MAEO_RS06630
uniprot id: A6UWK5
names: Similarity
messages: Belongs to the glutamate synthase family.

419665:MAEO RS00150
gene id: 419665:MAEO_RS00150
uniprot id: A6UT01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

419665:MAEO RS07185
gene id: 419665:MAEO_RS07185
uniprot id: A6UWV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

419665:MAEO RS03800
gene id: 419665:MAEO_RS03800
uniprot id: A6UV21
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

419665:MAEO RS02445
gene id: 419665:MAEO_RS02445
uniprot id: A6UUA6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

419665:MAEO RS00665
gene id: 419665:MAEO_RS00665
uniprot id: A6UTA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.

419665:MAEO RS05040
gene id: 419665:MAEO_RS05040
uniprot id: A6UVQ8
names: Similarity
messages: Belongs to the ComB family.

419665:MAEO RS00335
gene id: 419665:MAEO_RS00335
uniprot id: A6UT37
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

419665:MAEO RS05435
gene id: 419665:MAEO_RS05435
uniprot id: A6UVY4
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm5 family.
messages: This subunit might be involved in maturation of a crRNA intermediate to its mature form.

419665:MAEO RS01730
gene id: 419665:MAEO_RS01730
uniprot id: A6UTW3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

419665:MAEO RS02580
gene id: 419665:MAEO_RS02580
uniprot id: A6UUD3
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS06995
gene id: 419665:MAEO_RS06995
uniprot id: A6UWR7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

419665:MAEO RS00525
gene id: 419665:MAEO_RS00525
uniprot id: A6UT74
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

419665:MAEO RS03750
gene id: 419665:MAEO_RS03750
uniprot id: A6UV11
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: Consists of two subunits, CofG and CofH.

419665:MAEO RS05965
gene id: 419665:MAEO_RS05965
uniprot id: A6UW80
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

419665:MAEO RS00020
gene id: 419665:MAEO_RS00020
uniprot id: A6USX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

419665:MAEO RS05300
gene id: 419665:MAEO_RS05300
uniprot id: A6UVV7
names: Similarity
messages: Belongs to the NodU/CmcH family.

419665:MAEO RS00530
gene id: 419665:MAEO_RS00530
uniprot id: A6UT75
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

419665:MAEO RS03295
gene id: 419665:MAEO_RS03295
uniprot id: A6UUS4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

419665:MAEO RS06400
gene id: 419665:MAEO_RS06400
uniprot id: A6UWG0
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

419665:MAEO RS01870
gene id: 419665:MAEO_RS01870
uniprot id: A6UTZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

419665:MAEO RS03060
gene id: 419665:MAEO_RS03060
uniprot id: A6UUM7
names: Similarity
messages: Belongs to the UPF0284 family.

419665:MAEO RS00875
gene id: 419665:MAEO_RS00875
uniprot id: A6UTE4
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

419665:MAEO RS07345
gene id: 419665:MAEO_RS07345
uniprot id: A6UWY7
names: Similarity
messages: Belongs to the P(II) protein family.

419665:MAEO RS07240
gene id: 419665:MAEO_RS07240
uniprot id: A6UWW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

419665:MAEO RS04085
gene id: 419665:MAEO_RS04085
uniprot id: A6UV75
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS03810
gene id: 419665:MAEO_RS03810
uniprot id: A6UV23
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

419665:MAEO RS07095
gene id: 419665:MAEO_RS07095
uniprot id: A6UWT7
names: Similarity
messages: Belongs to the MEMO1 family.

419665:MAEO RS07225
gene id: 419665:MAEO_RS07225
uniprot id: A6UWW2
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS06930
gene id: 419665:MAEO_RS06930
uniprot id: A6UWQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Membrane

419665:MAEO RS00100
gene id: 419665:MAEO_RS00100
uniprot id: A6USZ1
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

419665:MAEO RS05490
gene id: 419665:MAEO_RS05490
uniprot id: A6UVZ5
names: Similarity
messages: Belongs to the HupF/HypC family.

419665:MAEO RS00730
gene id: 419665:MAEO_RS00730
uniprot id: A6UTB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

419665:MAEO RS06455
gene id: 419665:MAEO_RS06455
uniprot id: A6UWH0
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

419665:MAEO RS04125
gene id: 419665:MAEO_RS04125
uniprot id: A6UV80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.

419665:MAEO RS02320
gene id: 419665:MAEO_RS02320
uniprot id: A6UU80
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

419665:MAEO RS07200
gene id: 419665:MAEO_RS07200
uniprot id: A6UWV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

419665:MAEO RS01410
gene id: 419665:MAEO_RS01410
uniprot id: A6UTP9
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

419665:MAEO RS07440
gene id: 419665:MAEO_RS07440
uniprot id: A6UX06
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS05155
gene id: 419665:MAEO_RS05155
uniprot id: A6UVS9
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

419665:MAEO RS01230
gene id: 419665:MAEO_RS01230
uniprot id: A6UTL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

419665:MAEO RS01460
gene id: 419665:MAEO_RS01460
uniprot id: A6UTQ9
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

419665:MAEO RS07725
gene id: 419665:MAEO_RS07725
uniprot id: A6UTS1
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

419665:MAEO RS01885
gene id: 419665:MAEO_RS01885
uniprot id: A6UTZ4
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.

419665:MAEO RS00850
gene id: 419665:MAEO_RS00850
uniprot id: A6UTD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

419665:MAEO RS04225
gene id: 419665:MAEO_RS04225
uniprot id: A6UV99
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

419665:MAEO RS00330
gene id: 419665:MAEO_RS00330
uniprot id: A6UT36
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

419665:MAEO RS03385
gene id: 419665:MAEO_RS03385
uniprot id: A6UUU2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.

419665:MAEO RS03915
gene id: 419665:MAEO_RS03915
uniprot id: A6UV43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

419665:MAEO RS07470
gene id: 419665:MAEO_RS07470
uniprot id: A6UX12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

419665:MAEO RS03170
gene id: 419665:MAEO_RS03170
uniprot id: A6UUP9
names: Similarity
messages: Belongs to the UPF0146 family.

419665:MAEO RS00950
gene id: 419665:MAEO_RS00950
uniprot id: A6UTF9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

419665:MAEO RS04655
gene id: 419665:MAEO_RS04655
uniprot id: A6UVI5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Purine nucleoside phosphorylase involved in purine salvage.

419665:MAEO RS05985
gene id: 419665:MAEO_RS05985
uniprot id: A6UW84
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

419665:MAEO RS02845
gene id: 419665:MAEO_RS02845
uniprot id: A6UUI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

419665:MAEO RS00650
gene id: 419665:MAEO_RS00650
uniprot id: A6UT99
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

419665:MAEO RS03120
gene id: 419665:MAEO_RS03120
uniprot id: A6UUN9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

419665:MAEO RS05200
gene id: 419665:MAEO_RS05200
uniprot id: A6UVT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

419665:MAEO RS00895
gene id: 419665:MAEO_RS00895
uniprot id: A6UTE8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

419665:MAEO RS04020
gene id: 419665:MAEO_RS04020
uniprot id: A6UV64
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

419665:MAEO RS02160
gene id: 419665:MAEO_RS02160
uniprot id: A6UU47
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

419665:MAEO RS05900
gene id: 419665:MAEO_RS05900
uniprot id: A6UW69
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

419665:MAEO RS07025
gene id: 419665:MAEO_RS07025
uniprot id: A6UWS3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

419665:MAEO RS01975
gene id: 419665:MAEO_RS01975
uniprot id: A6UU11
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

419665:MAEO RS04775
gene id: 419665:MAEO_RS04775
uniprot id: A6UVK7
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

419665:MAEO RS04840
gene id: 419665:MAEO_RS04840
uniprot id: A6UVL9
names: Similarity
messages: Belongs to the DsrF/TusC family.

419665:MAEO RS03400
gene id: 419665:MAEO_RS03400
uniprot id: A6UUU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

419665:MAEO RS06870
gene id: 419665:MAEO_RS06870
uniprot id: A6UWP3
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

419665:MAEO RS07000
gene id: 419665:MAEO_RS07000
uniprot id: A6UWR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

419665:MAEO RS01760
gene id: 419665:MAEO_RS01760
uniprot id: A6UTW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.

419665:MAEO RS07575
gene id: 419665:MAEO_RS07575
uniprot id: A6UX34
names: Similarity
messages: Belongs to the P(II) protein family.

419665:MAEO RS07270
gene id: 419665:MAEO_RS07270
uniprot id: A6UWX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

419665:MAEO RS04820
gene id: 419665:MAEO_RS04820
uniprot id: A6UVL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

419665:MAEO RS03085
gene id: 419665:MAEO_RS03085
uniprot id: A6UUN2
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

419665:MAEO RS03390
gene id: 419665:MAEO_RS03390
uniprot id: A6UUU3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

419665:MAEO RS03805
gene id: 419665:MAEO_RS03805
uniprot id: A6UV22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

419665:MAEO RS07010
gene id: 419665:MAEO_RS07010
uniprot id: A6UWS0
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS07190
gene id: 419665:MAEO_RS07190
uniprot id: A6UWV5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

419665:MAEO RS03220
gene id: 419665:MAEO_RS03220
uniprot id: A6UUQ9
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS02920
gene id: 419665:MAEO_RS02920
uniprot id: A6UUK0
names: Similarity
messages: Belongs to the UPF0237 family.

419665:MAEO RS04730
gene id: 419665:MAEO_RS04730
uniprot id: A6UVJ8
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS05950
gene id: 419665:MAEO_RS05950
uniprot id: A6UW77
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

419665:MAEO RS07405
gene id: 419665:MAEO_RS07405
uniprot id: A6UWZ9
names: Similarity
messages: Belongs to the SAICAR synthetase family.

419665:MAEO RS02500
gene id: 419665:MAEO_RS02500
uniprot id: A6UUB7
names: Similarity
messages: Belongs to the glutaredoxin family.

419665:MAEO RS00690
gene id: 419665:MAEO_RS00690
uniprot id: A6UTA7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

419665:MAEO RS01365
gene id: 419665:MAEO_RS01365
uniprot id: A6UTP0
names: Similarity
messages: Belongs to the UPF0212 family.

419665:MAEO RS03165
gene id: 419665:MAEO_RS03165
uniprot id: A6UUP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

419665:MAEO RS02710
gene id: 419665:MAEO_RS02710
uniprot id: A6UUF9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

419665:MAEO RS00195
gene id: 419665:MAEO_RS00195
uniprot id: A6UT10
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

419665:MAEO RS00490
gene id: 419665:MAEO_RS00490
uniprot id: A6UT67
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

419665:MAEO RS06500
gene id: 419665:MAEO_RS06500
uniprot id: A6UWH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrG family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

419665:MAEO RS02535
gene id: 419665:MAEO_RS02535
uniprot id: A6UUC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

419665:MAEO RS00320
gene id: 419665:MAEO_RS00320
uniprot id: A6UT34
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

419665:MAEO RS07195
gene id: 419665:MAEO_RS07195
uniprot id: A6UWV6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

419665:MAEO RS01445
gene id: 419665:MAEO_RS01445
uniprot id: A6UTQ6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

419665:MAEO RS01340
gene id: 419665:MAEO_RS01340
uniprot id: A6UTN5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

419665:MAEO RS07650
gene id: 419665:MAEO_RS07650
uniprot id: A6UX48
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

419665:MAEO RS03910
gene id: 419665:MAEO_RS03910
uniprot id: A6UV42
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

419665:MAEO RS04450
gene id: 419665:MAEO_RS04450
uniprot id: A6UVE4
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS00955
gene id: 419665:MAEO_RS00955
uniprot id: A6UTG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

419665:MAEO RS00405
gene id: 419665:MAEO_RS00405
uniprot id: A6UT50
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

419665:MAEO RS00880
gene id: 419665:MAEO_RS00880
uniprot id: A6UTE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

419665:MAEO RS07420
gene id: 419665:MAEO_RS07420
uniprot id: A6UX02
names: Similarity
messages: Belongs to the TPP enzyme family.

419665:MAEO RS06075
gene id: 419665:MAEO_RS06075
uniprot id: A6UWA2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

419665:MAEO RS07035
gene id: 419665:MAEO_RS07035
uniprot id: A6UWS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
messages: Cell membrane

419665:MAEO RS03965
gene id: 419665:MAEO_RS03965
uniprot id: A6UV53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

419665:MAEO RS06910
gene id: 419665:MAEO_RS06910
uniprot id: A6UWQ0
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

419665:MAEO RS03195
gene id: 419665:MAEO_RS03195
uniprot id: A6UUQ4
names: Function
names: Similarity
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP-GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1-P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcNAc and pyrophosphate (By similarity).
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

419665:MAEO RS05755
gene id: 419665:MAEO_RS05755
uniprot id: A6UW45
names: Similarity
messages: Belongs to the AAA ATPase family.

419665:MAEO RS03035
gene id: 419665:MAEO_RS03035
uniprot id: A6UUM3
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

419665:MAEO RS07570
gene id: 419665:MAEO_RS07570
uniprot id: A6UX33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Membrane

419665:MAEO RS02345
gene id: 419665:MAEO_RS02345
uniprot id: A6UU86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

419665:MAEO RS06080
gene id: 419665:MAEO_RS06080
uniprot id: A6UWA3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

419665:MAEO RS03935
gene id: 419665:MAEO_RS03935
uniprot id: A6UV47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

419665:MAEO RS05720
gene id: 419665:MAEO_RS05720
uniprot id: A6UW38
names: Similarity
messages: Belongs to the HerA family.

419665:MAEO RS06000
gene id: 419665:MAEO_RS06000
uniprot id: A6UW87
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

419665:MAEO RS04035
gene id: 419665:MAEO_RS04035
uniprot id: A6UV67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

419665:MAEO RS03245
gene id: 419665:MAEO_RS03245
uniprot id: A6UUR4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

419665:MAEO RS01390
gene id: 419665:MAEO_RS01390
uniprot id: A6UTP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

419665:MAEO RS01235
gene id: 419665:MAEO_RS01235
uniprot id: A6UTL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

419665:MAEO RS03130
gene id: 419665:MAEO_RS03130
uniprot id: A6UUP1
names: Similarity
messages: Belongs to the class-I fumarase family.

419665:MAEO RS05905
gene id: 419665:MAEO_RS05905
uniprot id: A6UW70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

419665:MAEO RS03875
gene id: 419665:MAEO_RS03875
uniprot id: A6UV35
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

419665:MAEO RS05690
gene id: 419665:MAEO_RS05690
uniprot id: A6UW33
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

419665:MAEO RS03665
gene id: 419665:MAEO_RS03665
uniprot id: A6UUZ6
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS01450
gene id: 419665:MAEO_RS01450
uniprot id: A6UTQ7
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

419665:MAEO RS00140
gene id: 419665:MAEO_RS00140
uniprot id: A6USZ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.

419665:MAEO RS00505
gene id: 419665:MAEO_RS00505
uniprot id: A6UT70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

419665:MAEO RS00920
gene id: 419665:MAEO_RS00920
uniprot id: A6UTF3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

419665:MAEO RS05630
gene id: 419665:MAEO_RS05630
uniprot id: A6UW21
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

419665:MAEO RS06040
gene id: 419665:MAEO_RS06040
uniprot id: A6UW95
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

419665:MAEO RS01685
gene id: 419665:MAEO_RS01685
uniprot id: A6UTV4
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

419665:MAEO RS01080
gene id: 419665:MAEO_RS01080
uniprot id: A6UTI5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

419665:MAEO RS02170
gene id: 419665:MAEO_RS02170
uniprot id: A6UU49
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

419665:MAEO RS01005
gene id: 419665:MAEO_RS01005
uniprot id: A6UTH0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

419665:MAEO RS05195
gene id: 419665:MAEO_RS05195
uniprot id: A6UVT6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.
messages: Involved in F420 biosynthesis through the oxidation of lactaldehyde to lactate.

419665:MAEO RS06865
gene id: 419665:MAEO_RS06865
uniprot id: A6UWP2
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

419665:MAEO RS05450
gene id: 419665:MAEO_RS05450
uniprot id: A6UVY7
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm2 family.
messages: This subunit may be involved in monitoring complementarity of crRNA and target RNA.

419665:MAEO RS02285
gene id: 419665:MAEO_RS02285
uniprot id: A6UU73
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

419665:MAEO RS01400
gene id: 419665:MAEO_RS01400
uniprot id: A6UTP7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

419665:MAEO RS03510
gene id: 419665:MAEO_RS03510
uniprot id: A6UUW5
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

419665:MAEO RS06595
gene id: 419665:MAEO_RS06595
uniprot id: A6UWJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm

419665:MAEO RS01295
gene id: 419665:MAEO_RS01295
uniprot id: A6UTM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

419665:MAEO RS01550
gene id: 419665:MAEO_RS01550
uniprot id: A6UTS7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

419665:MAEO RS00315
gene id: 419665:MAEO_RS00315
uniprot id: A6UT33
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

419665:MAEO RS05795
gene id: 419665:MAEO_RS05795
uniprot id: A6UW49
names: Similarity
messages: Belongs to the MCM family.

419665:MAEO RS05415
gene id: 419665:MAEO_RS05415
uniprot id: A6UVY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

419665:MAEO RS03480
gene id: 419665:MAEO_RS03480
uniprot id: A6UUV9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

419665:MAEO RS04650
gene id: 419665:MAEO_RS04650
uniprot id: A6UVI4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).

419665:MAEO RS00945
gene id: 419665:MAEO_RS00945
uniprot id: A6UTF8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

419665:MAEO RS01545
gene id: 419665:MAEO_RS01545
uniprot id: A6UTS6
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

419665:MAEO RS07055
gene id: 419665:MAEO_RS07055
uniprot id: A6UWS9
names: Similarity
messages: Belongs to the IMPACT family.

419665:MAEO RS07605
gene id: 419665:MAEO_RS07605
uniprot id: A6UX39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

419665:MAEO RS03105
gene id: 419665:MAEO_RS03105
uniprot id: A6UUN6
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

419665:MAEO RS05100
gene id: 419665:MAEO_RS05100
uniprot id: A6UVR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

419665:MAEO RS01930
gene id: 419665:MAEO_RS01930
uniprot id: A6UU02
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

419665:MAEO RS02265
gene id: 419665:MAEO_RS02265
uniprot id: A6UU68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

419665:MAEO RS00085
gene id: 419665:MAEO_RS00085
uniprot id: A6USY8
names: Similarity
messages: Belongs to the UPF0166 family.

419665:MAEO RS05545
gene id: 419665:MAEO_RS05545
uniprot id: A6UW05
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

419665:MAEO RS01495
gene id: 419665:MAEO_RS01495
uniprot id: A6UTR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

419665:MAEO RS06565
gene id: 419665:MAEO_RS06565
uniprot id: A6UWJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

419665:MAEO RS00845
gene id: 419665:MAEO_RS00845
uniprot id: A6UTD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

419665:MAEO RS02435
gene id: 419665:MAEO_RS02435
uniprot id: A6UUA4
names: Similarity
messages: Belongs to the MCM family.

419665:MAEO RS03380
gene id: 419665:MAEO_RS03380
uniprot id: A6UUU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm

419665:MAEO RS03885
gene id: 419665:MAEO_RS03885
uniprot id: A6UV37
names: Function
messages: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.

419665:MAEO RS06495
gene id: 419665:MAEO_RS06495
uniprot id: A6UWH8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

419665:MAEO RS04425
gene id: 419665:MAEO_RS04425
uniprot id: A6UVD9
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS03005
gene id: 419665:MAEO_RS03005
uniprot id: A6UUL7
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

419665:MAEO RS03340
gene id: 419665:MAEO_RS03340
uniprot id: A6UUT3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

419665:MAEO RS06815
gene id: 419665:MAEO_RS06815
uniprot id: A6UWN2
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

419665:MAEO RS05700
gene id: 419665:MAEO_RS05700
uniprot id: A6UW34
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS03225
gene id: 419665:MAEO_RS03225
uniprot id: A6UUR0
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS01905
gene id: 419665:MAEO_RS01905
uniprot id: A6UTZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

419665:MAEO RS07500
gene id: 419665:MAEO_RS07500
uniprot id: A6UX18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

419665:MAEO RS04985
gene id: 419665:MAEO_RS04985
uniprot id: A6UVP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

419665:MAEO RS03330
gene id: 419665:MAEO_RS03330
uniprot id: A6UUT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

419665:MAEO RS00940
gene id: 419665:MAEO_RS00940
uniprot id: A6UTF7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

419665:MAEO RS03090
gene id: 419665:MAEO_RS03090
uniprot id: A6UUN3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

419665:MAEO RS05815
gene id: 419665:MAEO_RS05815
uniprot id: A6UW53
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

419665:MAEO RS01290
gene id: 419665:MAEO_RS01290
uniprot id: A6UTM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

419665:MAEO RS01125
gene id: 419665:MAEO_RS01125
uniprot id: A6UTJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

419665:MAEO RS04060
gene id: 419665:MAEO_RS04060
uniprot id: A6UV71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

419665:MAEO RS07475
gene id: 419665:MAEO_RS07475
uniprot id: A6UX13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

419665:MAEO RS00915
gene id: 419665:MAEO_RS00915
uniprot id: A6UTF2
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

419665:MAEO RS06670
gene id: 419665:MAEO_RS06670
uniprot id: A6UWL3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YjjX NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

419665:MAEO RS06660
gene id: 419665:MAEO_RS06660
uniprot id: A6UWL1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

419665:MAEO RS05130
gene id: 419665:MAEO_RS05130
uniprot id: A6UVS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0104 family.
messages: Membrane

419665:MAEO RS06050
gene id: 419665:MAEO_RS06050
uniprot id: A6UW97
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

419665:MAEO RS00245
gene id: 419665:MAEO_RS00245
uniprot id: A6UT20
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

419665:MAEO RS04380
gene id: 419665:MAEO_RS04380
uniprot id: A6UVD0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

419665:MAEO RS01200
gene id: 419665:MAEO_RS01200
uniprot id: A6UTK8
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

419665:MAEO RS06810
gene id: 419665:MAEO_RS06810
uniprot id: A6UWN1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

419665:MAEO RS07175
gene id: 419665:MAEO_RS07175
uniprot id: A6UWV2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

419665:MAEO RS04340
gene id: 419665:MAEO_RS04340
uniprot id: A6UVC2
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

419665:MAEO RS03960
gene id: 419665:MAEO_RS03960
uniprot id: A6UV52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.
messages: Part of the RNA polymerase complex.

419665:MAEO RS00520
gene id: 419665:MAEO_RS00520
uniprot id: A6UT73
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

419665:MAEO RS02880
gene id: 419665:MAEO_RS02880
uniprot id: A6UUJ2
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

419665:MAEO RS04615
gene id: 419665:MAEO_RS04615
uniprot id: A6UVH7
names: Similarity
messages: Belongs to the class-I fumarase family.

419665:MAEO RS00255
gene id: 419665:MAEO_RS00255
uniprot id: A6UT22
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

419665:MAEO RS00770
gene id: 419665:MAEO_RS00770
uniprot id: A6UTC3
names: Similarity
messages: Belongs to the phosphosulfolactate synthase family.

419665:MAEO RS00310
gene id: 419665:MAEO_RS00310
uniprot id: A6UT32
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

419665:MAEO RS06035
gene id: 419665:MAEO_RS06035
uniprot id: A6UW94
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.
messages: The N-terminal domain is an archaea-specific tRNA-editing domain that hydrolyzes incorrectly charged L-seryl-tRNA(Thr). Catalysis of tRNA editing is performed by the charged tRNA itself.

419665:MAEO RS05835
gene id: 419665:MAEO_RS05835
uniprot id: A6UW57
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

419665:MAEO RS01705
gene id: 419665:MAEO_RS01705
uniprot id: A6UTV8
names: Similarity
messages: Belongs to the UPF0280 family.

419665:MAEO RS07015
gene id: 419665:MAEO_RS07015
uniprot id: A6UWS1
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

419665:MAEO RS02760
gene id: 419665:MAEO_RS02760
uniprot id: A6UUG9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

419665:MAEO RS07125
gene id: 419665:MAEO_RS07125
uniprot id: A6UWU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

419665:MAEO RS04145
gene id: 419665:MAEO_RS04145
uniprot id: A6UV84
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

419665:MAEO RS02995
gene id: 419665:MAEO_RS02995
uniprot id: A6UUL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

419665:MAEO RS02690
gene id: 419665:MAEO_RS02690
uniprot id: A6UUF4
names: Similarity
messages: Belongs to the alkaline phosphatase family.

419665:MAEO RS03940
gene id: 419665:MAEO_RS03940
uniprot id: A6UV48
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

419665:MAEO RS07700
gene id: 419665:MAEO_RS07700
uniprot id: A6UX58
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

419665:MAEO RS05015
gene id: 419665:MAEO_RS05015
uniprot id: A6UVQ4
names: Similarity
messages: Belongs to the PDCD5 family.

419665:MAEO RS07085
gene id: 419665:MAEO_RS07085
uniprot id: A6UWT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiX family. CbiXS subfamily.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
messages: Homotetramer; dimer of dimers.

419665:MAEO RS00235
gene id: 419665:MAEO_RS00235
uniprot id: A6UT18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

419665:MAEO RS02305
gene id: 419665:MAEO_RS02305
uniprot id: A6UU77
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

419665:MAEO RS01155
gene id: 419665:MAEO_RS01155
uniprot id: A6UTK0
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

419665:MAEO RS00630
gene id: 419665:MAEO_RS00630
uniprot id: A6UT95
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

419665:MAEO RS02425
gene id: 419665:MAEO_RS02425
uniprot id: A6UUA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

419665:MAEO RS03395
gene id: 419665:MAEO_RS03395
uniprot id: A6UUU4
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

419665:MAEO RS00755
gene id: 419665:MAEO_RS00755
uniprot id: A6UTC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

419665:MAEO RS01270
gene id: 419665:MAEO_RS01270
uniprot id: A6UTM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

419665:MAEO RS07180
gene id: 419665:MAEO_RS07180
uniprot id: A6UWV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

419665:MAEO RS05880
gene id: 419665:MAEO_RS05880
uniprot id: A6UW65
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

419665:MAEO RS07555
gene id: 419665:MAEO_RS07555
uniprot id: A6UX29
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

419665:MAEO RS01670
gene id: 419665:MAEO_RS01670
uniprot id: A6UTV1
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS04510
gene id: 419665:MAEO_RS04510
uniprot id: A6UVF5
names: Similarity
messages: Belongs to the HypD family.

419665:MAEO RS00975
gene id: 419665:MAEO_RS00975
uniprot id: A6UTG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

419665:MAEO RS03870
gene id: 419665:MAEO_RS03870
uniprot id: A6UV34
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

419665:MAEO RS07065
gene id: 419665:MAEO_RS07065
uniprot id: A6UWT1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

419665:MAEO RS00445
gene id: 419665:MAEO_RS00445
uniprot id: A6UT58
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS00230
gene id: 419665:MAEO_RS00230
uniprot id: A6UT17
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

419665:MAEO RS05230
gene id: 419665:MAEO_RS05230
uniprot id: A6UVU4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

419665:MAEO RS01020
gene id: 419665:MAEO_RS01020
uniprot id: A6UTH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.

419665:MAEO RS00060
gene id: 419665:MAEO_RS00060
uniprot id: A6USY3
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

419665:MAEO RS04585
gene id: 419665:MAEO_RS04585
uniprot id: A6UVH1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

419665:MAEO RS02075
gene id: 419665:MAEO_RS02075
uniprot id: A6UU30
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS02200
gene id: 419665:MAEO_RS02200
uniprot id: A6UU55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

419665:MAEO RS05260
gene id: 419665:MAEO_RS05260
uniprot id: A6UVU9
names: Similarity
messages: Belongs to the FrhG family.

419665:MAEO RS04505
gene id: 419665:MAEO_RS04505
uniprot id: A6UVF4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

419665:MAEO RS02105
gene id: 419665:MAEO_RS02105
uniprot id: A6UU36
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

419665:MAEO RS05525
gene id: 419665:MAEO_RS05525
uniprot id: A6UW01
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

419665:MAEO RS02220
gene id: 419665:MAEO_RS02220
uniprot id: A6UU59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

419665:MAEO RS03430
gene id: 419665:MAEO_RS03430
uniprot id: A6UUV1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Reduced FMN (FMNH(2)).

419665:MAEO RS04735
gene id: 419665:MAEO_RS04735
uniprot id: A6UVJ9
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS06245
gene id: 419665:MAEO_RS06245
uniprot id: A6UWD0
names: Similarity
messages: Belongs to the MCM family.

419665:MAEO RS05125
gene id: 419665:MAEO_RS05125
uniprot id: A6UVS3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

419665:MAEO RS00370
gene id: 419665:MAEO_RS00370
uniprot id: A6UT43
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

419665:MAEO RS02815
gene id: 419665:MAEO_RS02815
uniprot id: A6UUI0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

419665:MAEO RS07620
gene id: 419665:MAEO_RS07620
uniprot id: A6UX42
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

419665:MAEO RS05275
gene id: 419665:MAEO_RS05275
uniprot id: A6UVV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

419665:MAEO RS05440
gene id: 419665:MAEO_RS05440
uniprot id: A6UVY5
names: Similarity
messages: Belongs to the CRISPR-associated Csm4 family.

419665:MAEO RS05475
gene id: 419665:MAEO_RS05475
uniprot id: A6UVZ2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

419665:MAEO RS04995
gene id: 419665:MAEO_RS04995
uniprot id: A6UVQ0
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

419665:MAEO RS05825
gene id: 419665:MAEO_RS05825
uniprot id: A6UW55
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

419665:MAEO RS06485
gene id: 419665:MAEO_RS06485
uniprot id: A6UWH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

419665:MAEO RS07505
gene id: 419665:MAEO_RS07505
uniprot id: A6UX19
names: Similarity
messages: Belongs to the gamma-class carbonic anhydrase family.

419665:MAEO RS03955
gene id: 419665:MAEO_RS03955
uniprot id: A6UV51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

419665:MAEO RS04210
gene id: 419665:MAEO_RS04210
uniprot id: A6UV96
names: Similarity
messages: Belongs to the peptidase M20A family.

419665:MAEO RS05990
gene id: 419665:MAEO_RS05990
uniprot id: A6UW85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

419665:MAEO RS04025
gene id: 419665:MAEO_RS04025
uniprot id: A6UV65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

419665:MAEO RS03625
gene id: 419665:MAEO_RS03625
uniprot id: A6UUY8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

419665:MAEO RS04755
gene id: 419665:MAEO_RS04755
uniprot id: A6UVK2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

419665:MAEO RS02835
gene id: 419665:MAEO_RS02835
uniprot id: A6UUI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

419665:MAEO RS04570
gene id: 419665:MAEO_RS04570
uniprot id: A6UVG8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

419665:MAEO RS03015
gene id: 419665:MAEO_RS03015
uniprot id: A6UUL9
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

419665:MAEO RS01415
gene id: 419665:MAEO_RS01415
uniprot id: A6UTQ0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

419665:MAEO RS03520
gene id: 419665:MAEO_RS03520
uniprot id: A6UUW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.

419665:MAEO RS03785
gene id: 419665:MAEO_RS03785
uniprot id: A6UV18
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

419665:MAEO RS02795
gene id: 419665:MAEO_RS02795
uniprot id: A6UUH6
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

419665:MAEO RS04070
gene id: 419665:MAEO_RS04070
uniprot id: A6UV73
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

419665:MAEO RS06165
gene id: 419665:MAEO_RS06165
uniprot id: A6UWC0
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

419665:MAEO RS03745
gene id: 419665:MAEO_RS03745
uniprot id: A6UV10
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

419665:MAEO RS07455
gene id: 419665:MAEO_RS07455
uniprot id: A6UX09
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

419665:MAEO RS05625
gene id: 419665:MAEO_RS05625
uniprot id: A6UW20
names: Similarity
messages: Belongs to the TrpC family.

419665:MAEO RS05025
gene id: 419665:MAEO_RS05025
uniprot id: A6UVQ6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

419665:MAEO RS01455
gene id: 419665:MAEO_RS01455
uniprot id: A6UTQ8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.

419665:MAEO RS07215
gene id: 419665:MAEO_RS07215
uniprot id: A6UWW0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

419665:MAEO RS00870
gene id: 419665:MAEO_RS00870
uniprot id: A6UTE3
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

419665:MAEO RS07565
gene id: 419665:MAEO_RS07565
uniprot id: A6UX31
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

419665:MAEO RS05225
gene id: 419665:MAEO_RS05225
uniprot id: A6UVU3
names: Similarity
messages: Belongs to the UPF0179 family.

419665:MAEO RS03950
gene id: 419665:MAEO_RS03950
uniprot id: A6UV50
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

419665:MAEO RS05290
gene id: 419665:MAEO_RS05290
uniprot id: A6UVV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
messages: Monomer.

419665:MAEO RS06955
gene id: 419665:MAEO_RS06955
uniprot id: A6UWQ9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

419665:MAEO RS03590
gene id: 419665:MAEO_RS03590
uniprot id: A6UUY1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

419665:MAEO RS05970
gene id: 419665:MAEO_RS05970
uniprot id: A6UW81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

419665:MAEO RS00810
gene id: 419665:MAEO_RS00810
uniprot id: A6UTD1
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS07560
gene id: 419665:MAEO_RS07560
uniprot id: A6UX30
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.

419665:MAEO RS06015
gene id: 419665:MAEO_RS06015
uniprot id: A6UW90
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

419665:MAEO RS06855
gene id: 419665:MAEO_RS06855
uniprot id: A6UWP0
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS04960
gene id: 419665:MAEO_RS04960
uniprot id: A6UVP3
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

419665:MAEO RS01575
gene id: 419665:MAEO_RS01575
uniprot id: A6UTT2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

419665:MAEO RS07660
gene id: 419665:MAEO_RS07660
uniprot id: A6UX50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

419665:MAEO RS05660
gene id: 419665:MAEO_RS05660
uniprot id: A6UW27
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

419665:MAEO RS06585
gene id: 419665:MAEO_RS06585
uniprot id: A6UWJ6
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Tetramer of two alpha and two beta subunits.

419665:MAEO RS04030
gene id: 419665:MAEO_RS04030
uniprot id: A6UV66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

419665:MAEO RS00460
gene id: 419665:MAEO_RS00460
uniprot id: A6UT61
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

419665:MAEO RS05335
gene id: 419665:MAEO_RS05335
uniprot id: A6UVW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

419665:MAEO RS06100
gene id: 419665:MAEO_RS06100
uniprot id: A6UWA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

419665:MAEO RS03185
gene id: 419665:MAEO_RS03185
uniprot id: A6UUQ2
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

419665:MAEO RS04535
gene id: 419665:MAEO_RS04535
uniprot id: A6UVG0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

419665:MAEO RS03570
gene id: 419665:MAEO_RS03570
uniprot id: A6UUX7
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS03300
gene id: 419665:MAEO_RS03300
uniprot id: A6UUS5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the creatininase superfamily. FAPy deformylase family.
messages: Catalyzes the hydrolysis of the formamide of 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy).
messages: Homodimer.
messages: Requires an additional second metal ion that could be Fe(2+) or Zn(2+).
messages: Requires one Fe(2+) ion for activity.

419665:MAEO RS06760
gene id: 419665:MAEO_RS06760
uniprot id: A6UWM0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

419665:MAEO RS01645
gene id: 419665:MAEO_RS01645
uniprot id: A6UTU6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

419665:MAEO RS04200
gene id: 419665:MAEO_RS04200
uniprot id: A6UV94
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

419665:MAEO RS05565
gene id: 419665:MAEO_RS05565
uniprot id: A6UW08
names: Similarity
messages: Belongs to the UPF0305 family.

419665:MAEO RS02165
gene id: 419665:MAEO_RS02165
uniprot id: A6UU48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

419665:MAEO RS03315
gene id: 419665:MAEO_RS03315
uniprot id: A6UUS8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

419665:MAEO RS00855
gene id: 419665:MAEO_RS00855
uniprot id: A6UTE0
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

419665:MAEO RS00890
gene id: 419665:MAEO_RS00890
uniprot id: A6UTE7
names: Function
messages: Probably involved in the biogenesis of the ribosome.

419665:MAEO RS05740
gene id: 419665:MAEO_RS05740
uniprot id: A6UW42
names: Similarity
messages: Belongs to the MtxX family.

419665:MAEO RS00910
gene id: 419665:MAEO_RS00910
uniprot id: A6UTF1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

419665:MAEO RS07235
gene id: 419665:MAEO_RS07235
uniprot id: A6UWW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

419665:MAEO RS07030
gene id: 419665:MAEO_RS07030
uniprot id: A6UWS4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

419665:MAEO RS03850
gene id: 419665:MAEO_RS03850
uniprot id: A6UV30
names: Similarity
messages: Belongs to the band 7/mec-2 family.

419665:MAEO RS00015
gene id: 419665:MAEO_RS00015
uniprot id: A6USX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

419665:MAEO RS07375
gene id: 419665:MAEO_RS07375
uniprot id: A6UWZ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

419665:MAEO RS06830
gene id: 419665:MAEO_RS06830
uniprot id: A6UWN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

419665:MAEO RS06465
gene id: 419665:MAEO_RS06465
uniprot id: A6UWH2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Cytoplasm
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

419665:MAEO RS06490
gene id: 419665:MAEO_RS06490
uniprot id: A6UWH7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

419665:MAEO RS06205
gene id: 419665:MAEO_RS06205
uniprot id: A6UWC8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-98 inactivates the nitrogenase reductase and regulates nitrogenase activity.

419665:MAEO RS05240
gene id: 419665:MAEO_RS05240
uniprot id: A6UVU6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

419665:MAEO RS00025
gene id: 419665:MAEO_RS00025
uniprot id: A6USX6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Cytoplasm

419665:MAEO RS04640
gene id: 419665:MAEO_RS04640
uniprot id: A6UVI2
names: Similarity
messages: Belongs to the DMRL synthase family.

419665:MAEO RS01300
gene id: 419665:MAEO_RS01300
uniprot id: A6UTM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

419665:MAEO RS04440
gene id: 419665:MAEO_RS04440
uniprot id: A6UVE2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

419665:MAEO RS00165
gene id: 419665:MAEO_RS00165
uniprot id: A6UT04
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

419665:MAEO RS07685
gene id: 419665:MAEO_RS07685
uniprot id: A6UX55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

419665:MAEO RS02890
gene id: 419665:MAEO_RS02890
uniprot id: A6UUJ4
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS06145
gene id: 419665:MAEO_RS06145
uniprot id: A6UWB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

419665:MAEO RS07250
gene id: 419665:MAEO_RS07250
uniprot id: A6UWW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.

419665:MAEO RS06095
gene id: 419665:MAEO_RS06095
uniprot id: A6UWA6
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

419665:MAEO RS03280
gene id: 419665:MAEO_RS03280
uniprot id: A6UUS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm

419665:MAEO RS00210
gene id: 419665:MAEO_RS00210
uniprot id: A6UT13
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

419665:MAEO RS06445
gene id: 419665:MAEO_RS06445
uniprot id: A6UWG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Cytoplasm
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

419665:MAEO RS00965
gene id: 419665:MAEO_RS00965
uniprot id: A6UTG2
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

419665:MAEO RS04955
gene id: 419665:MAEO_RS04955
uniprot id: A6UVP2
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

419665:MAEO RS03350
gene id: 419665:MAEO_RS03350
uniprot id: A6UUT5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

419665:MAEO RS01530
gene id: 419665:MAEO_RS01530
uniprot id: A6UTS3
names: Similarity
messages: Belongs to the HdrC family.

419665:MAEO RS07220
gene id: 419665:MAEO_RS07220
uniprot id: A6UWW1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

419665:MAEO RS04550
gene id: 419665:MAEO_RS04550
uniprot id: A6UVG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

419665:MAEO RS07160
gene id: 419665:MAEO_RS07160
uniprot id: A6UWU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

419665:MAEO RS00995
gene id: 419665:MAEO_RS00995
uniprot id: A6UTG8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aldolase class II family. AraD/FucA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the biosynthesis of the coenzyme F420 which requires phospholactate produced via the aldol cleavage of L-fuculose 1-phosphate and the NAD(+)-dependent oxidation of (S)-lactaldehyde. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and S-lactaldehyde.

419665:MAEO RS01000
gene id: 419665:MAEO_RS01000
uniprot id: A6UTG9
names: Similarity
messages: Belongs to the UPF0147 family.

419665:MAEO RS03080
gene id: 419665:MAEO_RS03080
uniprot id: A6UUN1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

419665:MAEO RS04555
gene id: 419665:MAEO_RS04555
uniprot id: A6UVG4
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

419665:MAEO RS01050
gene id: 419665:MAEO_RS01050
uniprot id: A6UTI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhD family.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex.

419665:MAEO RS00275
gene id: 419665:MAEO_RS00275
uniprot id: A6UT26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

419665:MAEO RS06535
gene id: 419665:MAEO_RS06535
uniprot id: A6UWI6
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

419665:MAEO RS05085
gene id: 419665:MAEO_RS05085
uniprot id: A6UVR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

419665:MAEO RS01570
gene id: 419665:MAEO_RS01570
uniprot id: A6UTT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

419665:MAEO RS02460
gene id: 419665:MAEO_RS02460
uniprot id: A6UUA9
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

419665:MAEO RS06835
gene id: 419665:MAEO_RS06835
uniprot id: A6UWN6
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS02540
gene id: 419665:MAEO_RS02540
uniprot id: A6UUC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

419665:MAEO RS03680
gene id: 419665:MAEO_RS03680
uniprot id: A6UUZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

419665:MAEO RS04915
gene id: 419665:MAEO_RS04915
uniprot id: A6UVN4
names: Similarity
messages: Belongs to the UPF0285 family.

419665:MAEO RS00860
gene id: 419665:MAEO_RS00860
uniprot id: A6UTE1
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

419665:MAEO RS06460
gene id: 419665:MAEO_RS06460
uniprot id: A6UWH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Cytoplasm
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

419665:MAEO RS00720
gene id: 419665:MAEO_RS00720
uniprot id: A6UTB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

419665:MAEO RS00410
gene id: 419665:MAEO_RS00410
uniprot id: A6UT51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

419665:MAEO RS00365
gene id: 419665:MAEO_RS00365
uniprot id: A6UT42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

419665:MAEO RS02635
gene id: 419665:MAEO_RS02635
uniprot id: A6UUE5
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS01240
gene id: 419665:MAEO_RS01240
uniprot id: A6UTL6
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

419665:MAEO RS06885
gene id: 419665:MAEO_RS06885
uniprot id: A6UWP6
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

419665:MAEO RS00640
gene id: 419665:MAEO_RS00640
uniprot id: A6UT97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

419665:MAEO RS01665
gene id: 419665:MAEO_RS01665
uniprot id: A6UTV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

419665:MAEO RS00935
gene id: 419665:MAEO_RS00935
uniprot id: A6UTF6
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

419665:MAEO RS05850
gene id: 419665:MAEO_RS05850
uniprot id: A6UW60
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

419665:MAEO RS04275
gene id: 419665:MAEO_RS04275
uniprot id: A6UVA9
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Homodimer.

419665:MAEO RS05915
gene id: 419665:MAEO_RS05915
uniprot id: A6UW72
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

419665:MAEO RS06550
gene id: 419665:MAEO_RS06550
uniprot id: A6UWI9
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

419665:MAEO RS04120
gene id: 419665:MAEO_RS04120
uniprot id: A6UV79
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

419665:MAEO RS03710
gene id: 419665:MAEO_RS03710
uniprot id: A6UV05
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.

419665:MAEO RS02215
gene id: 419665:MAEO_RS02215
uniprot id: A6UU58
names: Similarity
messages: Belongs to the AOR/FOR family.

419665:MAEO RS06695
gene id: 419665:MAEO_RS06695
uniprot id: A6UWL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

419665:MAEO RS03535
gene id: 419665:MAEO_RS03535
uniprot id: A6UUX0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

419665:MAEO RS01985
gene id: 419665:MAEO_RS01985
uniprot id: A6UU13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

419665:MAEO RS02360
gene id: 419665:MAEO_RS02360
uniprot id: A6UU89
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

419665:MAEO RS02330
gene id: 419665:MAEO_RS02330
uniprot id: A6UU82
names: Similarity
messages: Belongs to the SAICAR synthetase family.

419665:MAEO RS05570
gene id: 419665:MAEO_RS05570
uniprot id: A6UW09
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS03675
gene id: 419665:MAEO_RS03675
uniprot id: A6UUZ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

419665:MAEO RS05010
gene id: 419665:MAEO_RS05010
uniprot id: A6UVQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

419665:MAEO RS06790
gene id: 419665:MAEO_RS06790
uniprot id: A6UWM6
names: Similarity
messages: Belongs to the GARS family.

419665:MAEO RS05685
gene id: 419665:MAEO_RS05685
uniprot id: A6UW32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

419665:MAEO RS05410
gene id: 419665:MAEO_RS05410
uniprot id: A6UVX9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

419665:MAEO RS03235
gene id: 419665:MAEO_RS03235
uniprot id: A6UUR2
names: Similarity
messages: Belongs to the acylphosphatase family.

419665:MAEO RS01540
gene id: 419665:MAEO_RS01540
uniprot id: A6UTS5
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

419665:MAEO RS05330
gene id: 419665:MAEO_RS05330
uniprot id: A6UVW3
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

419665:MAEO RS03335
gene id: 419665:MAEO_RS03335
uniprot id: A6UUT2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

419665:MAEO RS07335
gene id: 419665:MAEO_RS07335
uniprot id: A6UWY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

419665:MAEO RS05110
gene id: 419665:MAEO_RS05110
uniprot id: A6UVS0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers.

419665:MAEO RS04270
gene id: 419665:MAEO_RS04270
uniprot id: A6UVA8
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

419665:MAEO RS03925
gene id: 419665:MAEO_RS03925
uniprot id: A6UV45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

419665:MAEO RS01405
gene id: 419665:MAEO_RS01405
uniprot id: A6UTP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

419665:MAEO RS05075
gene id: 419665:MAEO_RS05075
uniprot id: A6UVR3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

419665:MAEO RS05320
gene id: 419665:MAEO_RS05320
uniprot id: A6UVW1
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

419665:MAEO RS00455
gene id: 419665:MAEO_RS00455
uniprot id: A6UT60
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS06820
gene id: 419665:MAEO_RS06820
uniprot id: A6UWN3
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

419665:MAEO RS02130
gene id: 419665:MAEO_RS02130
uniprot id: A6UU41
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

419665:MAEO RS06175
gene id: 419665:MAEO_RS06175
uniprot id: A6UWC2
names: Similarity
messages: Belongs to the HisA/HisF family.

419665:MAEO RS02600
gene id: 419665:MAEO_RS02600
uniprot id: A6UUD7
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS05705
gene id: 419665:MAEO_RS05705
uniprot id: A6UW35
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm
messages: Monomer.

419665:MAEO RS07280
gene id: 419665:MAEO_RS07280
uniprot id: A6UWX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

419665:MAEO RS05920
gene id: 419665:MAEO_RS05920
uniprot id: A6UW73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

419665:MAEO RS05210
gene id: 419665:MAEO_RS05210
uniprot id: A6UVT9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

419665:MAEO RS06650
gene id: 419665:MAEO_RS06650
uniprot id: A6UWK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm

419665:MAEO RS01525
gene id: 419665:MAEO_RS01525
uniprot id: A6UTS2
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

419665:MAEO RS02280
gene id: 419665:MAEO_RS02280
uniprot id: A6UU72
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

419665:MAEO RS03865
gene id: 419665:MAEO_RS03865
uniprot id: A6UV33
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

419665:MAEO RS04375
gene id: 419665:MAEO_RS04375
uniprot id: A6UVC9
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

419665:MAEO RS06470
gene id: 419665:MAEO_RS06470
uniprot id: A6UWH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

419665:MAEO RS03450
gene id: 419665:MAEO_RS03450
uniprot id: A6UUV5
names: Similarity
messages: Belongs to the HMD family.

419665:MAEO RS07245
gene id: 419665:MAEO_RS07245
uniprot id: A6UWW6
names: Similarity
messages: Belongs to the UPF0210 family.

419665:MAEO RS06375
gene id: 419665:MAEO_RS06375
uniprot id: A6UWF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

419665:MAEO RS05520
gene id: 419665:MAEO_RS05520
uniprot id: A6UW00
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

419665:MAEO RS05890
gene id: 419665:MAEO_RS05890
uniprot id: A6UW67
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

419665:MAEO RS02180
gene id: 419665:MAEO_RS02180
uniprot id: A6UU51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

419665:MAEO RS01355
gene id: 419665:MAEO_RS01355
uniprot id: A6UTN8
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

419665:MAEO RS01055
gene id: 419665:MAEO_RS01055
uniprot id: A6UTI1
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).

419665:MAEO RS05515
gene id: 419665:MAEO_RS05515
uniprot id: A6UVZ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

419665:MAEO RS02275
gene id: 419665:MAEO_RS02275
uniprot id: A6UU71
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

419665:MAEO RS02185
gene id: 419665:MAEO_RS02185
uniprot id: A6UU52
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

419665:MAEO RS03495
gene id: 419665:MAEO_RS03495
uniprot id: A6UUW2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

419665:MAEO RS01245
gene id: 419665:MAEO_RS01245
uniprot id: A6UTL7
names: Similarity
messages: Belongs to the acylphosphatase family.

419665:MAEO RS03075
gene id: 419665:MAEO_RS03075
uniprot id: A6UUN0
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

419665:MAEO RS07680
gene id: 419665:MAEO_RS07680
uniprot id: A6UX54
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

419665:MAEO RS06055
gene id: 419665:MAEO_RS06055
uniprot id: A6UW98
names: Similarity
messages: Belongs to the UPF0201 family.

419665:MAEO RS07410
gene id: 419665:MAEO_RS07410
uniprot id: A6UX00
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

419665:MAEO RS05540
gene id: 419665:MAEO_RS05540
uniprot id: A6UW04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

419665:MAEO RS05120
gene id: 419665:MAEO_RS05120
uniprot id: A6UVS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

419665:MAEO RS07210
gene id: 419665:MAEO_RS07210
uniprot id: A6UWV9
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

419665:MAEO RS01720
gene id: 419665:MAEO_RS01720
uniprot id: A6UTW1
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

419665:MAEO RS03545
gene id: 419665:MAEO_RS03545
uniprot id: A6UUX2
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

419665:MAEO RS05080
gene id: 419665:MAEO_RS05080
uniprot id: A6UVR4
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.

419665:MAEO RS06480
gene id: 419665:MAEO_RS06480
uniprot id: A6UWH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

419665:MAEO RS07530
gene id: 419665:MAEO_RS07530
uniprot id: A6UX24
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.

419665:MAEO RS03325
gene id: 419665:MAEO_RS03325
uniprot id: A6UUT0
names: Similarity
messages: Belongs to the UPF0254 family.

419665:MAEO RS01640
gene id: 419665:MAEO_RS01640
uniprot id: A6UTU5
names: Similarity
messages: Belongs to the glutaredoxin family.

419665:MAEO RS07145
gene id: 419665:MAEO_RS07145
uniprot id: A6UWU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

419665:MAEO RS01650
gene id: 419665:MAEO_RS01650
uniprot id: A6UTU7
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

419665:MAEO RS00360
gene id: 419665:MAEO_RS00360
uniprot id: A6UT41
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

419665:MAEO RS02245
gene id: 419665:MAEO_RS02245
uniprot id: A6UU64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

419665:MAEO RS03500
gene id: 419665:MAEO_RS03500
uniprot id: A6UUW3
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

419665:MAEO RS04590
gene id: 419665:MAEO_RS04590
uniprot id: A6UVH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

419665:MAEO RS00865
gene id: 419665:MAEO_RS00865
uniprot id: A6UTE2
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS01475
gene id: 419665:MAEO_RS01475
uniprot id: A6UTR2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

419665:MAEO RS01845
gene id: 419665:MAEO_RS01845
uniprot id: A6UTY6
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

419665:MAEO RS02135
gene id: 419665:MAEO_RS02135
uniprot id: A6UU42
names: Similarity
messages: Belongs to the polysaccharide synthase family.

419665:MAEO RS04830
gene id: 419665:MAEO_RS04830
uniprot id: A6UVL7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

419665:MAEO RS03775
gene id: 419665:MAEO_RS03775
uniprot id: A6UV16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

419665:MAEO RS04345
gene id: 419665:MAEO_RS04345
uniprot id: A6UVC3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

419665:MAEO RS07595
gene id: 419665:MAEO_RS07595
uniprot id: A6UX37
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily.
messages: Binds 1 Zn(2+) ion per subunit. This ion is coordinated with 2 cysteines, 1 glutamate and a water molecule that dissociates from the zinc ion to allow the coordination of the amino group of the serine substrate, which is essential for catalysis.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is presumably involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer.

419665:MAEO RS07130
gene id: 419665:MAEO_RS07130
uniprot id: A6UWU3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

419665:MAEO RS07580
gene id: 419665:MAEO_RS07580
uniprot id: A6UX35
names: Similarity
messages: Belongs to the P(II) protein family.

419665:MAEO RS03655
gene id: 419665:MAEO_RS03655
uniprot id: A6UUZ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

419665:MAEO RS01725
gene id: 419665:MAEO_RS01725
uniprot id: A6UTW2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

419665:MAEO RS06065
gene id: 419665:MAEO_RS06065
uniprot id: A6UWA0
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

419665:MAEO RS04040
gene id: 419665:MAEO_RS04040
uniprot id: A6UV68
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

419665:MAEO RS02000
gene id: 419665:MAEO_RS02000
uniprot id: A6UU16
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

419665:MAEO RS06130
gene id: 419665:MAEO_RS06130
uniprot id: A6UWB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

419665:MAEO RS06010
gene id: 419665:MAEO_RS06010
uniprot id: A6UW89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).

419665:MAEO RS01250
gene id: 419665:MAEO_RS01250
uniprot id: A6UTL8
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

419665:MAEO RS03365
gene id: 419665:MAEO_RS03365
uniprot id: A6UUT8
names: Similarity
messages: Belongs to the aspartokinase family.

419665:MAEO RS00905
gene id: 419665:MAEO_RS00905
uniprot id: A6UTF0
names: Similarity
messages: Belongs to the SDO1/SBDS family.

419665:MAEO RS03205
gene id: 419665:MAEO_RS03205
uniprot id: A6UUQ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

419665:MAEO RS05090
gene id: 419665:MAEO_RS05090
uniprot id: A6UVR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

419665:MAEO RS04420
gene id: 419665:MAEO_RS04420
uniprot id: A6UVD8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

419665:MAEO RS01175
gene id: 419665:MAEO_RS01175
uniprot id: A6UTK4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

419665:MAEO RS00900
gene id: 419665:MAEO_RS00900
uniprot id: A6UTE9
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.
messages: Binds 1 zinc ion per subunit.

419665:MAEO RS05560
gene id: 419665:MAEO_RS05560
uniprot id: A6UW07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

419665:MAEO RS04745
gene id: 419665:MAEO_RS04745
uniprot id: A6UVK1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

419665:MAEO RS00305
gene id: 419665:MAEO_RS00305
uniprot id: A6UT31
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

419665:MAEO RS02785
gene id: 419665:MAEO_RS02785
uniprot id: A6UUH4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

419665:MAEO RS01100
gene id: 419665:MAEO_RS01100
uniprot id: A6UTI9
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS04195
gene id: 419665:MAEO_RS04195
uniprot id: A6UV93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

419665:MAEO RS04160
gene id: 419665:MAEO_RS04160
uniprot id: A6UV87
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

419665:MAEO RS07115
gene id: 419665:MAEO_RS07115
uniprot id: A6UWU0
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

419665:MAEO RS01775
gene id: 419665:MAEO_RS01775
uniprot id: A6UTX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EhaA family.
messages: Cell membrane
messages: Membrane
messages: One of the integral membrane subunits of multisubunit membrane-bound [NiFe]-hydrogenase eha. Eha is predicted to form large electron transfer complex and might catalyze energy-driven reduction of low-potential redox carriers.
messages: Putative multisubunit membrane-bound [NiFe]-hydrogenase eha is composed of at least 20 subunits.

419665:MAEO RS07640
gene id: 419665:MAEO_RS07640
uniprot id: A6UX46
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

419665:MAEO RS03505
gene id: 419665:MAEO_RS03505
uniprot id: A6UUW4
names: Similarity
messages: Belongs to the eIF-2-alpha family.

419665:MAEO RS02945
gene id: 419665:MAEO_RS02945
uniprot id: A6UUK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

419665:MAEO RS00065
gene id: 419665:MAEO_RS00065
uniprot id: A6USY4
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

419665:MAEO RS04935
gene id: 419665:MAEO_RS04935
uniprot id: A6UVN8
names: Caution
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

419665:MAEO RS05170
gene id: 419665:MAEO_RS05170
uniprot id: A6UVT1
names: Function
names: Similarity
messages: Belongs to the HMD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

419665:MAEO RS03025
gene id: 419665:MAEO_RS03025
uniprot id: A6UUM1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

419665:MAEO RS03095
gene id: 419665:MAEO_RS03095
uniprot id: A6UUN4
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

419665:MAEO RS05420
gene id: 419665:MAEO_RS05420
uniprot id: A6UVY1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

419665:MAEO RS04580
gene id: 419665:MAEO_RS04580
uniprot id: A6UVH0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: Consists of two subunits, CofG and CofH.

419665:MAEO RS07365
gene id: 419665:MAEO_RS07365
uniprot id: A6UWZ1
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS01710
gene id: 419665:MAEO_RS01710
uniprot id: A6UTV9
names: Similarity
messages: Belongs to the thymidylate kinase family.

419665:MAEO RS06380
gene id: 419665:MAEO_RS06380
uniprot id: A6UWF6
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

419665:MAEO RS03930
gene id: 419665:MAEO_RS03930
uniprot id: A6UV46
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

419665:MAEO RS02400
gene id: 419665:MAEO_RS02400
uniprot id: A6UU96
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

419665:MAEO RS00765
gene id: 419665:MAEO_RS00765
uniprot id: A6UTC2
names: Similarity
messages: Belongs to the UPF0111 family.

419665:MAEO RS04595
gene id: 419665:MAEO_RS04595
uniprot id: A6UVH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

419665:MAEO RS04600
gene id: 419665:MAEO_RS04600
uniprot id: A6UVH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

419665:MAEO RS04445
gene id: 419665:MAEO_RS04445
uniprot id: A6UVE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.

419665:MAEO RS07285
gene id: 419665:MAEO_RS07285
uniprot id: A6UWX4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BioW family.
messages: Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.
messages: Homodimer.

419665:MAEO RS06645
gene id: 419665:MAEO_RS06645
uniprot id: A6UWK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

419665:MAEO RS00160
gene id: 419665:MAEO_RS00160
uniprot id: A6UT03
names: Similarity
messages: Belongs to the phosphohexose mutase family.

419665:MAEO RS02515
gene id: 419665:MAEO_RS02515
uniprot id: A6UUC0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-109 inactivates the nitrogenase reductase and regulates nitrogenase activity.

419665:MAEO RS02390
gene id: 419665:MAEO_RS02390
uniprot id: A6UU95
names: Similarity
messages: Belongs to the UPF0045 family.

419665:MAEO RS03115
gene id: 419665:MAEO_RS03115
uniprot id: A6UUN8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

419665:MAEO RS05345
gene id: 419665:MAEO_RS05345
uniprot id: A6UVW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

419665:MAEO RS04410
gene id: 419665:MAEO_RS04410
uniprot id: A6UVD6
names: Similarity
messages: Belongs to the FUN14 family.

419665:MAEO RS04215
gene id: 419665:MAEO_RS04215
uniprot id: A6UV97
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

419665:MAEO RS02700
gene id: 419665:MAEO_RS02700
uniprot id: A6UUF7
names: Similarity
messages: Belongs to the pyruvate kinase family.

419665:MAEO RS02780
gene id: 419665:MAEO_RS02780
uniprot id: A6UUH3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

419665:MAEO RS05175
gene id: 419665:MAEO_RS05175
uniprot id: A6UVT2
names: Cofactor
names: Similarity
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

419665:MAEO RS04565
gene id: 419665:MAEO_RS04565
uniprot id: A6UVG7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

419665:MAEO RS03070
gene id: 419665:MAEO_RS03070
uniprot id: A6UUM9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

419665:MAEO RS00885
gene id: 419665:MAEO_RS00885
uniprot id: A6UTE6
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

419665:MAEO RS06420
gene id: 419665:MAEO_RS06420
uniprot id: A6UWG4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

419665:MAEO RS04925
gene id: 419665:MAEO_RS04925
uniprot id: A6UVN6
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

419665:MAEO RS02325
gene id: 419665:MAEO_RS02325
uniprot id: A6UU81
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

419665:MAEO RS00750
gene id: 419665:MAEO_RS00750
uniprot id: A6UTB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

419665:MAEO RS06560
gene id: 419665:MAEO_RS06560
uniprot id: A6UWJ1
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

419665:MAEO RS07135
gene id: 419665:MAEO_RS07135
uniprot id: A6UWU4
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

419665:MAEO RS07585
gene id: 419665:MAEO_RS07585
uniprot id: A6UX36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

419665:MAEO RS06085
gene id: 419665:MAEO_RS06085
uniprot id: A6UWA4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

419665:MAEO RS06020
gene id: 419665:MAEO_RS06020
uniprot id: A6UW91
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

419665:MAEO RS00030
gene id: 419665:MAEO_RS00030
uniprot id: A6USX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

419665:MAEO RS04605
gene id: 419665:MAEO_RS04605
uniprot id: A6UVH5
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

419665:MAEO RS03920
gene id: 419665:MAEO_RS03920
uniprot id: A6UV44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

419665:MAEO RS05445
gene id: 419665:MAEO_RS05445
uniprot id: A6UVY6
names: Similarity
messages: Belongs to the CRISPR-associated Csm3 family.

419665:MAEO RS01765
gene id: 419665:MAEO_RS01765
uniprot id: A6UTX0
names: Similarity
messages: Belongs to the ZPR1 family.

419665:MAEO RS03310
gene id: 419665:MAEO_RS03310
uniprot id: A6UUS7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

419665:MAEO RS06030
gene id: 419665:MAEO_RS06030
uniprot id: A6UW93
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

419665:MAEO RS03375
gene id: 419665:MAEO_RS03375
uniprot id: A6UUU0
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

419665:MAEO RS05455
gene id: 419665:MAEO_RS05455
uniprot id: A6UVY8
names: Similarity
messages: Belongs to the CRISPR-associated Cas10/Csm1 family.

419665:MAEO RS00515
gene id: 419665:MAEO_RS00515
uniprot id: A6UT72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

419665:MAEO RS03360
gene id: 419665:MAEO_RS03360
uniprot id: A6UUT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
messages: Homodimer.

419665:MAEO RS02810
gene id: 419665:MAEO_RS02810
uniprot id: A6UUH9
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

419665:MAEO RS04720
gene id: 419665:MAEO_RS04720
uniprot id: A6UVJ6
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

419665:MAEO RS04080
gene id: 419665:MAEO_RS04080
uniprot id: A6UV74
names: Caution
names: Similarity
messages: Belongs to the UPF0200 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

419665:MAEO RS00980
gene id: 419665:MAEO_RS00980
uniprot id: A6UTG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

419665:MAEO RS00480
gene id: 419665:MAEO_RS00480
uniprot id: A6UT65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

419665:MAEO RS00250
gene id: 419665:MAEO_RS00250
uniprot id: A6UT21
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

419665:MAEO RS01255
gene id: 419665:MAEO_RS01255
uniprot id: A6UTL9
names: Function
names: Similarity
messages: Belongs to the 2-phosphoglycerate kinase family.
messages: Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant.

419665:MAEO RS02575
gene id: 419665:MAEO_RS02575
uniprot id: A6UUD2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

419665:MAEO RS03485
gene id: 419665:MAEO_RS03485
uniprot id: A6UUW0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

419665:MAEO RS02555
gene id: 419665:MAEO_RS02555
uniprot id: A6UUC8
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

419665:MAEO RS07460
gene id: 419665:MAEO_RS07460
uniprot id: A6UX10
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

419665:MAEO RS05000
gene id: 419665:MAEO_RS05000
uniprot id: A6UVQ1
names: Similarity
messages: Belongs to the UPF0288 family.

419665:MAEO RS03275
gene id: 419665:MAEO_RS03275
uniprot id: A6UUS0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

419665:MAEO RS07550
gene id: 419665:MAEO_RS07550
uniprot id: A6UX28
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

419665:MAEO RS06805
gene id: 419665:MAEO_RS06805
uniprot id: A6UWM9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

419665:MAEO RS05530
gene id: 419665:MAEO_RS05530
uniprot id: A6UW02
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

419665:MAEO RS07155
gene id: 419665:MAEO_RS07155
uniprot id: A6UWU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

419665:MAEO RS00710
gene id: 419665:MAEO_RS00710
uniprot id: A6UTB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

419665:MAEO RS07045
gene id: 419665:MAEO_RS07045
uniprot id: A6UWS7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

419665:MAEO RS03640
gene id: 419665:MAEO_RS03640
uniprot id: A6UUZ1
names: Similarity
messages: Belongs to the peptidase C56 family.

419665:MAEO RS02295
gene id: 419665:MAEO_RS02295
uniprot id: A6UU75
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

419665:MAEO RS05840
gene id: 419665:MAEO_RS05840
uniprot id: A6UW58
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

419665:MAEO RS04950
gene id: 419665:MAEO_RS04950
uniprot id: A6UVP1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

419665:MAEO RS03405
gene id: 419665:MAEO_RS03405
uniprot id: A6UUU6
names: Similarity
messages: Belongs to the HypE family.

419665:MAEO RS07315
gene id: 419665:MAEO_RS07315
uniprot id: A6UWY1
names: Function
names: Subunit
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

419665:MAEO RS07070
gene id: 419665:MAEO_RS07070
uniprot id: A6UWT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

419665:MAEO RS01945
gene id: 419665:MAEO_RS01945
uniprot id: A6UU05
names: Subcellular Location Annotation
messages: Membrane

419665:MAEO RS00795
gene id: 419665:MAEO_RS00795
uniprot id: A6UTC8
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

419665:MAEO RS02270
gene id: 419665:MAEO_RS02270
uniprot id: A6UU70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

419665:MAEO RS03550
gene id: 419665:MAEO_RS03550
uniprot id: A6UUX3
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

419665:MAEO RS00325
gene id: 419665:MAEO_RS00325
uniprot id: A6UT35
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

419665:MAEO RS05895
gene id: 419665:MAEO_RS05895
uniprot id: A6UW68
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

419665:MAEO RS03250
gene id: 419665:MAEO_RS03250
uniprot id: A6UUR5
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

419665:MAEO RS00400
gene id: 419665:MAEO_RS00400
uniprot id: A6UT49
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

419665:MAEO RS03795
gene id: 419665:MAEO_RS03795
uniprot id: A6UV20
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

419665:MAEO RS04335
gene id: 419665:MAEO_RS04335
uniprot id: A6UVC1
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

419665:MAEO RS05390
gene id: 419665:MAEO_RS05390
uniprot id: A6UVX5
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

419665:MAEO RS00840
gene id: 419665:MAEO_RS00840
uniprot id: A6UTD7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

419665:MAEO RS07170
gene id: 419665:MAEO_RS07170
uniprot id: A6UWV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

419665:MAEO RS07050
gene id: 419665:MAEO_RS07050
uniprot id: A6UWS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S16 family.
messages: Membrane

419665:MAEO RS06090
gene id: 419665:MAEO_RS06090
uniprot id: A6UWA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

419665:MAEO RS00570
gene id: 419665:MAEO_RS00570
uniprot id: A6UT83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

419665:MAEO RS06675
gene id: 419665:MAEO_RS06675
uniprot id: A6UWL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

419665:MAEO RS07150
gene id: 419665:MAEO_RS07150
uniprot id: A6UWU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

419665:MAEO RS05650
gene id: 419665:MAEO_RS05650
uniprot id: A6UW25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

419665:MAEO RS02550
gene id: 419665:MAEO_RS02550
uniprot id: A6UUC7
names: Similarity
messages: Belongs to the MoaB/Mog family.