410358:MLAB RS06185
gene id: 410358:MLAB_RS06185
uniprot id: A2SSN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

410358:MLAB RS07715
gene id: 410358:MLAB_RS07715
uniprot id: A2STG7
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS00900
gene id: 410358:MLAB_RS00900
uniprot id: A2SPU2
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS07275
gene id: 410358:MLAB_RS07275
uniprot id: A2ST82
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

410358:MLAB RS07170
gene id: 410358:MLAB_RS07170
uniprot id: A2ST64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

410358:MLAB RS01675
gene id: 410358:MLAB_RS01675
uniprot id: A2SQ91
names: Similarity
messages: Belongs to the SUI1 family.

410358:MLAB RS00450
gene id: 410358:MLAB_RS00450
uniprot id: A2SPK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

410358:MLAB RS00020
gene id: 410358:MLAB_RS00020
uniprot id: A2SPC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

410358:MLAB RS07875
gene id: 410358:MLAB_RS07875
uniprot id: A2STJ3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

410358:MLAB RS03235
gene id: 410358:MLAB_RS03235
uniprot id: A2SR33
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

410358:MLAB RS08745
gene id: 410358:MLAB_RS08745
uniprot id: A2SU10
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

410358:MLAB RS06540
gene id: 410358:MLAB_RS06540
uniprot id: A2SSV1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

410358:MLAB RS07025
gene id: 410358:MLAB_RS07025
uniprot id: A2ST38
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Homooctamer; dimer of tetramers.

410358:MLAB RS03595
gene id: 410358:MLAB_RS03595
uniprot id: A2SRA1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

410358:MLAB RS07245
gene id: 410358:MLAB_RS07245
uniprot id: A2ST76
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

410358:MLAB RS08305
gene id: 410358:MLAB_RS08305
uniprot id: A2STS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

410358:MLAB RS08750
gene id: 410358:MLAB_RS08750
uniprot id: A2SU11
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

410358:MLAB RS05750
gene id: 410358:MLAB_RS05750
uniprot id: A2SSF0
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

410358:MLAB RS08175
gene id: 410358:MLAB_RS08175
uniprot id: A2STQ1
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

410358:MLAB RS06165
gene id: 410358:MLAB_RS06165
uniprot id: A2SSN1
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

410358:MLAB RS03375
gene id: 410358:MLAB_RS03375
uniprot id: A2SR59
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

410358:MLAB RS07480
gene id: 410358:MLAB_RS07480
uniprot id: A2STC1
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

410358:MLAB RS02365
gene id: 410358:MLAB_RS02365
uniprot id: A2SQL5
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

410358:MLAB RS05240
gene id: 410358:MLAB_RS05240
uniprot id: A2SS58
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

410358:MLAB RS08540
gene id: 410358:MLAB_RS08540
uniprot id: A2STX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

410358:MLAB RS00615
gene id: 410358:MLAB_RS00615
uniprot id: A2SPN7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

410358:MLAB RS00440
gene id: 410358:MLAB_RS00440
uniprot id: A2SPK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

410358:MLAB RS07465
gene id: 410358:MLAB_RS07465
uniprot id: A2STB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

410358:MLAB RS08470
gene id: 410358:MLAB_RS08470
uniprot id: A2STV9
names: Similarity
messages: Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.

410358:MLAB RS08740
gene id: 410358:MLAB_RS08740
uniprot id: A2SU09
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

410358:MLAB RS08030
gene id: 410358:MLAB_RS08030
uniprot id: A2STM4
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

410358:MLAB RS08370
gene id: 410358:MLAB_RS08370
uniprot id: A2STU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

410358:MLAB RS05375
gene id: 410358:MLAB_RS05375
uniprot id: A2SS78
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

410358:MLAB RS07840
gene id: 410358:MLAB_RS07840
uniprot id: A2STI7
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

410358:MLAB RS05915
gene id: 410358:MLAB_RS05915
uniprot id: A2SSI3
names: Similarity
messages: Belongs to the Nth/MutY family.

410358:MLAB RS06375
gene id: 410358:MLAB_RS06375
uniprot id: A2SSS1
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

410358:MLAB RS01140
gene id: 410358:MLAB_RS01140
uniprot id: A2SPZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Probably functions as a manganese efflux pump.

410358:MLAB RS06730
gene id: 410358:MLAB_RS06730
uniprot id: A2SSY4
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

410358:MLAB RS04160
gene id: 410358:MLAB_RS04160
uniprot id: A2SRK9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

410358:MLAB RS06830
gene id: 410358:MLAB_RS06830
uniprot id: A2ST04
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

410358:MLAB RS00460
gene id: 410358:MLAB_RS00460
uniprot id: A2SPK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

410358:MLAB RS06240
gene id: 410358:MLAB_RS06240
uniprot id: A2SSP6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

410358:MLAB RS08600
gene id: 410358:MLAB_RS08600
uniprot id: A2STY2
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

410358:MLAB RS00220
gene id: 410358:MLAB_RS00220
uniprot id: A2SPG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

410358:MLAB RS04425
gene id: 410358:MLAB_RS04425
uniprot id: A2SRQ8
names: Similarity
messages: Belongs to the HsdR family.

410358:MLAB RS06390
gene id: 410358:MLAB_RS06390
uniprot id: A2SSS4
names: Similarity
messages: Belongs to the HypD family.

410358:MLAB RS07385
gene id: 410358:MLAB_RS07385
uniprot id: A2STA4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

410358:MLAB RS02840
gene id: 410358:MLAB_RS02840
uniprot id: A2SQV7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

410358:MLAB RS03770
gene id: 410358:MLAB_RS03770
uniprot id: A2SRD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

410358:MLAB RS09125
gene id: 410358:MLAB_RS09125
uniprot id: A2SU78
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

410358:MLAB RS05945
gene id: 410358:MLAB_RS05945
uniprot id: A2SSI9
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

410358:MLAB RS02805
gene id: 410358:MLAB_RS02805
uniprot id: A2SQV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

410358:MLAB RS00825
gene id: 410358:MLAB_RS00825
uniprot id: A2SPS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

410358:MLAB RS07340
gene id: 410358:MLAB_RS07340
uniprot id: A2ST95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

410358:MLAB RS07640
gene id: 410358:MLAB_RS07640
uniprot id: A2STF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

410358:MLAB RS02860
gene id: 410358:MLAB_RS02860
uniprot id: A2SQW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

410358:MLAB RS01985
gene id: 410358:MLAB_RS01985
uniprot id: A2SQE9
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

410358:MLAB RS01475
gene id: 410358:MLAB_RS01475
uniprot id: A2SQ57
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

410358:MLAB RS03440
gene id: 410358:MLAB_RS03440
uniprot id: A2SR71
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Part of the 30S ribosomal subunit.

410358:MLAB RS03280
gene id: 410358:MLAB_RS03280
uniprot id: A2SR40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

410358:MLAB RS05230
gene id: 410358:MLAB_RS05230
uniprot id: A2SS56
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

410358:MLAB RS04490
gene id: 410358:MLAB_RS04490
uniprot id: A2SRS1
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS03270
gene id: 410358:MLAB_RS03270
uniprot id: A2SR38
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

410358:MLAB RS08820
gene id: 410358:MLAB_RS08820
uniprot id: A2SU20
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

410358:MLAB RS08840
gene id: 410358:MLAB_RS08840
uniprot id: A2SU24
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS05415
gene id: 410358:MLAB_RS05415
uniprot id: A2SS86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

410358:MLAB RS05740
gene id: 410358:MLAB_RS05740
uniprot id: A2SSE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

410358:MLAB RS00425
gene id: 410358:MLAB_RS00425
uniprot id: A2SPK1
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

410358:MLAB RS00565
gene id: 410358:MLAB_RS00565
uniprot id: A2SPM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

410358:MLAB RS05655
gene id: 410358:MLAB_RS05655
uniprot id: A2SSD1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

410358:MLAB RS01860
gene id: 410358:MLAB_RS01860
uniprot id: A2SQC6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

410358:MLAB RS05920
gene id: 410358:MLAB_RS05920
uniprot id: A2SSI4
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

410358:MLAB RS08270
gene id: 410358:MLAB_RS08270
uniprot id: A2STS0
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

410358:MLAB RS07495
gene id: 410358:MLAB_RS07495
uniprot id: A2STC4
names: Similarity
messages: Belongs to the UPF0285 family.

410358:MLAB RS03500
gene id: 410358:MLAB_RS03500
uniprot id: A2SR82
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

410358:MLAB RS01230
gene id: 410358:MLAB_RS01230
uniprot id: A2SQ09
names: Similarity
messages: Belongs to the HdrC family.

410358:MLAB RS08180
gene id: 410358:MLAB_RS08180
uniprot id: A2STQ2
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

410358:MLAB RS05805
gene id: 410358:MLAB_RS05805
uniprot id: A2SSG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

410358:MLAB RS01890
gene id: 410358:MLAB_RS01890
uniprot id: A2SQD1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Binds two Mg(2+) per subunit.
messages: Forms a ternary complex with MCM helicase and DNA.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

410358:MLAB RS00515
gene id: 410358:MLAB_RS00515
uniprot id: A2SPL8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

410358:MLAB RS06005
gene id: 410358:MLAB_RS06005
uniprot id: A2SSK0
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

410358:MLAB RS03225
gene id: 410358:MLAB_RS03225
uniprot id: A2SR31
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

410358:MLAB RS01340
gene id: 410358:MLAB_RS01340
uniprot id: A2SQ30
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS00535
gene id: 410358:MLAB_RS00535
uniprot id: A2SPM2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

410358:MLAB RS06150
gene id: 410358:MLAB_RS06150
uniprot id: A2SSM8
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS04065
gene id: 410358:MLAB_RS04065
uniprot id: A2SRJ0
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

410358:MLAB RS00875
gene id: 410358:MLAB_RS00875
uniprot id: A2SPT7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

410358:MLAB RS02345
gene id: 410358:MLAB_RS02345
uniprot id: A2SQL2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

410358:MLAB RS05295
gene id: 410358:MLAB_RS05295
uniprot id: A2SS67
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

410358:MLAB RS00470
gene id: 410358:MLAB_RS00470
uniprot id: A2SPL0
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

410358:MLAB RS08050
gene id: 410358:MLAB_RS08050
uniprot id: A2STM8
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

410358:MLAB RS09340
gene id: 410358:MLAB_RS09340
uniprot id: A2SQ90
names: Similarity
messages: Belongs to the UPF0305 family.

410358:MLAB RS08245
gene id: 410358:MLAB_RS08245
uniprot id: A2STR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

410358:MLAB RS06025
gene id: 410358:MLAB_RS06025
uniprot id: A2SSK4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

410358:MLAB RS07150
gene id: 410358:MLAB_RS07150
uniprot id: A2ST60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

410358:MLAB RS01955
gene id: 410358:MLAB_RS01955
uniprot id: A2SQE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

410358:MLAB RS00415
gene id: 410358:MLAB_RS00415
uniprot id: A2SPJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

410358:MLAB RS08660
gene id: 410358:MLAB_RS08660
uniprot id: A2STZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

410358:MLAB RS00970
gene id: 410358:MLAB_RS00970
uniprot id: A2SPV6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

410358:MLAB RS05830
gene id: 410358:MLAB_RS05830
uniprot id: A2SSG6
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

410358:MLAB RS03330
gene id: 410358:MLAB_RS03330
uniprot id: A2SR50
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

410358:MLAB RS05420
gene id: 410358:MLAB_RS05420
uniprot id: A2SS87
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

410358:MLAB RS09245
gene id: 410358:MLAB_RS09245
uniprot id: A2SU99
names: Function
names: Similarity
messages: Belongs to the HMD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

410358:MLAB RS05650
gene id: 410358:MLAB_RS05650
uniprot id: A2SSD0
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

410358:MLAB RS04475
gene id: 410358:MLAB_RS04475
uniprot id: A2SRR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

410358:MLAB RS03435
gene id: 410358:MLAB_RS03435
uniprot id: A2SR70
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

410358:MLAB RS09285
gene id: 410358:MLAB_RS09285
uniprot id: A2SUA7
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

410358:MLAB RS07105
gene id: 410358:MLAB_RS07105
uniprot id: A2ST51
names: Similarity
messages: Belongs to the SDO1/SBDS family.

410358:MLAB RS01265
gene id: 410358:MLAB_RS01265
uniprot id: A2SQ16
names: Similarity
messages: Belongs to the FwdC/FmdC family.

410358:MLAB RS06455
gene id: 410358:MLAB_RS06455
uniprot id: A2SST5
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

410358:MLAB RS00850
gene id: 410358:MLAB_RS00850
uniprot id: A2SPT2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

410358:MLAB RS06545
gene id: 410358:MLAB_RS06545
uniprot id: A2SSV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

410358:MLAB RS05835
gene id: 410358:MLAB_RS05835
uniprot id: A2SSG7
names: Similarity
messages: Belongs to the helicase family. RAD3/XPD subfamily.

410358:MLAB RS05955
gene id: 410358:MLAB_RS05955
uniprot id: A2SSJ1
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

410358:MLAB RS03700
gene id: 410358:MLAB_RS03700
uniprot id: A2SRC0
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS09230
gene id: 410358:MLAB_RS09230
uniprot id: A2SU96
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

410358:MLAB RS07330
gene id: 410358:MLAB_RS07330
uniprot id: A2ST93
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

410358:MLAB RS02150
gene id: 410358:MLAB_RS02150
uniprot id: A2SQH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

410358:MLAB RS01820
gene id: 410358:MLAB_RS01820
uniprot id: A2SQB8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

410358:MLAB RS00750
gene id: 410358:MLAB_RS00750
uniprot id: A2SPR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

410358:MLAB RS00465
gene id: 410358:MLAB_RS00465
uniprot id: A2SPK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

410358:MLAB RS00325
gene id: 410358:MLAB_RS00325
uniprot id: A2SPI6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

410358:MLAB RS04365
gene id: 410358:MLAB_RS04365
uniprot id: A2SRP6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

410358:MLAB RS03825
gene id: 410358:MLAB_RS03825
uniprot id: A2SRE5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

410358:MLAB RS03765
gene id: 410358:MLAB_RS03765
uniprot id: A2SRD3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

410358:MLAB RS00540
gene id: 410358:MLAB_RS00540
uniprot id: A2SPM3
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

410358:MLAB RS00165
gene id: 410358:MLAB_RS00165
uniprot id: A2SPF4
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

410358:MLAB RS03890
gene id: 410358:MLAB_RS03890
uniprot id: A2SRF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

410358:MLAB RS03190
gene id: 410358:MLAB_RS03190
uniprot id: A2SR24
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

410358:MLAB RS08895
gene id: 410358:MLAB_RS08895
uniprot id: A2SU34
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS07820
gene id: 410358:MLAB_RS07820
uniprot id: A2STI4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

410358:MLAB RS05210
gene id: 410358:MLAB_RS05210
uniprot id: A2SS52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

410358:MLAB RS02335
gene id: 410358:MLAB_RS02335
uniprot id: A2SQL0
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

410358:MLAB RS01855
gene id: 410358:MLAB_RS01855
uniprot id: A2SQC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

410358:MLAB RS06460
gene id: 410358:MLAB_RS06460
uniprot id: A2SST6
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

410358:MLAB RS02830
gene id: 410358:MLAB_RS02830
uniprot id: A2SQV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

410358:MLAB RS07110
gene id: 410358:MLAB_RS07110
uniprot id: A2ST52
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

410358:MLAB RS00240
gene id: 410358:MLAB_RS00240
uniprot id: A2SPG9
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

410358:MLAB RS01355
gene id: 410358:MLAB_RS01355
uniprot id: A2SQ33
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

410358:MLAB RS09400
gene id: 410358:MLAB_RS09400
uniprot id: A2SRQ7
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

410358:MLAB RS02125
gene id: 410358:MLAB_RS02125
uniprot id: A2SQH3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

410358:MLAB RS08845
gene id: 410358:MLAB_RS08845
uniprot id: A2SU25
names: Similarity
messages: Belongs to the leucine-binding protein family.

410358:MLAB RS03355
gene id: 410358:MLAB_RS03355
uniprot id: A2SR55
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

410358:MLAB RS02625
gene id: 410358:MLAB_RS02625
uniprot id: A2SQR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

410358:MLAB RS02790
gene id: 410358:MLAB_RS02790
uniprot id: A2SQU7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

410358:MLAB RS07085
gene id: 410358:MLAB_RS07085
uniprot id: A2ST48
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

410358:MLAB RS05875
gene id: 410358:MLAB_RS05875
uniprot id: A2SSH5
names: Subcellular Location Annotation
messages: Cytoplasm

410358:MLAB RS05525
gene id: 410358:MLAB_RS05525
uniprot id: A2SSA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

410358:MLAB RS07300
gene id: 410358:MLAB_RS07300
uniprot id: A2ST87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

410358:MLAB RS01975
gene id: 410358:MLAB_RS01975
uniprot id: A2SQE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

410358:MLAB RS02395
gene id: 410358:MLAB_RS02395
uniprot id: A2SQM1
names: Similarity
messages: Belongs to the UPF0280 family.

410358:MLAB RS07080
gene id: 410358:MLAB_RS07080
uniprot id: A2ST47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

410358:MLAB RS02945
gene id: 410358:MLAB_RS02945
uniprot id: A2SQX8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

410358:MLAB RS03910
gene id: 410358:MLAB_RS03910
uniprot id: A2SRG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

410358:MLAB RS02105
gene id: 410358:MLAB_RS02105
uniprot id: A2SQG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

410358:MLAB RS07935
gene id: 410358:MLAB_RS07935
uniprot id: A2STK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

410358:MLAB RS08645
gene id: 410358:MLAB_RS08645
uniprot id: A2STZ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

410358:MLAB RS05455
gene id: 410358:MLAB_RS05455
uniprot id: A2SS94
names: Similarity
messages: Belongs to the UPF0237 family.

410358:MLAB RS03745
gene id: 410358:MLAB_RS03745
uniprot id: A2SRC9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

410358:MLAB RS07345
gene id: 410358:MLAB_RS07345
uniprot id: A2ST96
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

410358:MLAB RS04965
gene id: 410358:MLAB_RS04965
uniprot id: A2SS06
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

410358:MLAB RS00230
gene id: 410358:MLAB_RS00230
uniprot id: A2SPG7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

410358:MLAB RS08300
gene id: 410358:MLAB_RS08300
uniprot id: A2STS6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

410358:MLAB RS03030
gene id: 410358:MLAB_RS03030
uniprot id: A2SQZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

410358:MLAB RS05000
gene id: 410358:MLAB_RS05000
uniprot id: A2SS13
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

410358:MLAB RS01090
gene id: 410358:MLAB_RS01090
uniprot id: A2SPY1
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

410358:MLAB RS08870
gene id: 410358:MLAB_RS08870
uniprot id: A2SU30
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.

410358:MLAB RS07390
gene id: 410358:MLAB_RS07390
uniprot id: A2STA5
names: Similarity
messages: Belongs to the TrpF family.

410358:MLAB RS03170
gene id: 410358:MLAB_RS03170
uniprot id: A2SR20
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.

410358:MLAB RS01065
gene id: 410358:MLAB_RS01065
uniprot id: A2SPX6
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

410358:MLAB RS01905
gene id: 410358:MLAB_RS01905
uniprot id: A2SQD4
names: Similarity
messages: Belongs to the HypE family.

410358:MLAB RS04115
gene id: 410358:MLAB_RS04115
uniprot id: A2SRK0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

410358:MLAB RS08720
gene id: 410358:MLAB_RS08720
uniprot id: A2SU05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

410358:MLAB RS05950
gene id: 410358:MLAB_RS05950
uniprot id: A2SSJ0
names: Caution
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

410358:MLAB RS00480
gene id: 410358:MLAB_RS00480
uniprot id: A2SPL1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

410358:MLAB RS02575
gene id: 410358:MLAB_RS02575
uniprot id: A2SQQ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

410358:MLAB RS04360
gene id: 410358:MLAB_RS04360
uniprot id: A2SRP5
names: Similarity
messages: Belongs to the MCM family.

410358:MLAB RS04210
gene id: 410358:MLAB_RS04210
uniprot id: A2SRL8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

410358:MLAB RS08045
gene id: 410358:MLAB_RS08045
uniprot id: A2STM7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

410358:MLAB RS06630
gene id: 410358:MLAB_RS06630
uniprot id: A2SSW8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

410358:MLAB RS01370
gene id: 410358:MLAB_RS01370
uniprot id: A2SQ36
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: In Archaea the pyridoxal phosphate cofactor is not covalently bound to Lys but ligated by other amino acids.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

410358:MLAB RS01650
gene id: 410358:MLAB_RS01650
uniprot id: A2SQ86
names: Cofactor
names: Similarity
messages: Belongs to the GARS family.
messages: Binds 2 magnesium or manganese ions per subunit.

410358:MLAB RS03835
gene id: 410358:MLAB_RS03835
uniprot id: A2SRE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

410358:MLAB RS06020
gene id: 410358:MLAB_RS06020
uniprot id: A2SSK3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

410358:MLAB RS03125
gene id: 410358:MLAB_RS03125
uniprot id: A2SR11
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

410358:MLAB RS08365
gene id: 410358:MLAB_RS08365
uniprot id: A2STT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

410358:MLAB RS08295
gene id: 410358:MLAB_RS08295
uniprot id: A2STS5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

410358:MLAB RS00485
gene id: 410358:MLAB_RS00485
uniprot id: A2SPL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

410358:MLAB RS08755
gene id: 410358:MLAB_RS08755
uniprot id: A2SU12
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

410358:MLAB RS08625
gene id: 410358:MLAB_RS08625
uniprot id: A2STY7
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

410358:MLAB RS08230
gene id: 410358:MLAB_RS08230
uniprot id: A2STR2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Belongs to the MtrG family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

410358:MLAB RS06875
gene id: 410358:MLAB_RS06875
uniprot id: A2ST12
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

410358:MLAB RS00530
gene id: 410358:MLAB_RS00530
uniprot id: A2SPM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

410358:MLAB RS06910
gene id: 410358:MLAB_RS06910
uniprot id: A2ST18
names: Similarity
messages: Belongs to the UPF0179 family.

410358:MLAB RS01915
gene id: 410358:MLAB_RS01915
uniprot id: A2SQD6
names: Similarity
messages: Belongs to the HupF/HypC family.

410358:MLAB RS03335
gene id: 410358:MLAB_RS03335
uniprot id: A2SR51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

410358:MLAB RS02820
gene id: 410358:MLAB_RS02820
uniprot id: A2SQV3
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

410358:MLAB RS04355
gene id: 410358:MLAB_RS04355
uniprot id: A2SRP4
names: Similarity
messages: Belongs to the thioesterase PaaI family.

410358:MLAB RS01645
gene id: 410358:MLAB_RS01645
uniprot id: A2SQ85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.

410358:MLAB RS01830
gene id: 410358:MLAB_RS01830
uniprot id: A2SQC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

410358:MLAB RS07960
gene id: 410358:MLAB_RS07960
uniprot id: A2STL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

410358:MLAB RS08730
gene id: 410358:MLAB_RS08730
uniprot id: A2SU07
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

410358:MLAB RS07270
gene id: 410358:MLAB_RS07270
uniprot id: A2ST81
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

410358:MLAB RS01070
gene id: 410358:MLAB_RS01070
uniprot id: A2SPX7
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

410358:MLAB RS02810
gene id: 410358:MLAB_RS02810
uniprot id: A2SQV1
names: Similarity
messages: Belongs to the class-I fumarase family.

410358:MLAB RS02110
gene id: 410358:MLAB_RS02110
uniprot id: A2SQH0
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

410358:MLAB RS00215
gene id: 410358:MLAB_RS00215
uniprot id: A2SPG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

410358:MLAB RS09325
gene id: 410358:MLAB_RS09325
uniprot id: A2SPN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

410358:MLAB RS00090
gene id: 410358:MLAB_RS00090
uniprot id: A2SPE0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

410358:MLAB RS01235
gene id: 410358:MLAB_RS01235
uniprot id: A2SQ10
names: Similarity
messages: Belongs to the HdrB family.

410358:MLAB RS01205
gene id: 410358:MLAB_RS01205
uniprot id: A2SQ04
names: Similarity
messages: Belongs to the LeuD family. LeuD type 2 subfamily.

410358:MLAB RS00420
gene id: 410358:MLAB_RS00420
uniprot id: A2SPK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

410358:MLAB RS02190
gene id: 410358:MLAB_RS02190
uniprot id: A2SQI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

410358:MLAB RS04960
gene id: 410358:MLAB_RS04960
uniprot id: A2SS05
names: Similarity
messages: Belongs to the PurH family.

410358:MLAB RS04935
gene id: 410358:MLAB_RS04935
uniprot id: A2SS01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

410358:MLAB RS09000
gene id: 410358:MLAB_RS09000
uniprot id: A2SU54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).

410358:MLAB RS01095
gene id: 410358:MLAB_RS01095
uniprot id: A2SPY2
names: Similarity
messages: Belongs to the polypeptide deformylase family.

410358:MLAB RS02420
gene id: 410358:MLAB_RS02420
uniprot id: A2SQM6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

410358:MLAB RS07680
gene id: 410358:MLAB_RS07680
uniprot id: A2STG0
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

410358:MLAB RS06195
gene id: 410358:MLAB_RS06195
uniprot id: A2SSN7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

410358:MLAB RS01000
gene id: 410358:MLAB_RS01000
uniprot id: A2SPW3
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS01440
gene id: 410358:MLAB_RS01440
uniprot id: A2SQ49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

410358:MLAB RS06435
gene id: 410358:MLAB_RS06435
uniprot id: A2SST1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

410358:MLAB RS07610
gene id: 410358:MLAB_RS07610
uniprot id: A2STE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

410358:MLAB RS03975
gene id: 410358:MLAB_RS03975
uniprot id: A2SRH4
names: Similarity
messages: Belongs to the tRNA(His) guanylyltransferase family.

410358:MLAB RS00580
gene id: 410358:MLAB_RS00580
uniprot id: A2SPN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
messages: Monomer.

410358:MLAB RS04560
gene id: 410358:MLAB_RS04560
uniprot id: A2SRT2
names: Similarity
messages: Belongs to the AAA ATPase family.

410358:MLAB RS07905
gene id: 410358:MLAB_RS07905
uniprot id: A2STJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

410358:MLAB RS07945
gene id: 410358:MLAB_RS07945
uniprot id: A2STK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

410358:MLAB RS03350
gene id: 410358:MLAB_RS03350
uniprot id: A2SR54
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

410358:MLAB RS09025
gene id: 410358:MLAB_RS09025
uniprot id: A2SU59
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS01655
gene id: 410358:MLAB_RS01655
uniprot id: A2SQ87
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

410358:MLAB RS03580
gene id: 410358:MLAB_RS03580
uniprot id: A2SR98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

410358:MLAB RS06090
gene id: 410358:MLAB_RS06090
uniprot id: A2SSL7
names: Similarity
messages: Belongs to the UPF0173 family.

410358:MLAB RS07630
gene id: 410358:MLAB_RS07630
uniprot id: A2STF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

410358:MLAB RS05155
gene id: 410358:MLAB_RS05155
uniprot id: A2SS43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

410358:MLAB RS09080
gene id: 410358:MLAB_RS09080
uniprot id: A2SU70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

410358:MLAB RS00495
gene id: 410358:MLAB_RS00495
uniprot id: A2SPL4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

410358:MLAB RS01270
gene id: 410358:MLAB_RS01270
uniprot id: A2SQ17
names: Similarity
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

410358:MLAB RS07380
gene id: 410358:MLAB_RS07380
uniprot id: A2STA3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

410358:MLAB RS00800
gene id: 410358:MLAB_RS00800
uniprot id: A2SPS3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.

410358:MLAB RS06845
gene id: 410358:MLAB_RS06845
uniprot id: A2ST07
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

410358:MLAB RS09010
gene id: 410358:MLAB_RS09010
uniprot id: A2SU56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

410358:MLAB RS05560
gene id: 410358:MLAB_RS05560
uniprot id: A2SSB3
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS08430
gene id: 410358:MLAB_RS08430
uniprot id: A2STV2
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS05880
gene id: 410358:MLAB_RS05880
uniprot id: A2SSH6
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS06735
gene id: 410358:MLAB_RS06735
uniprot id: A2SSY5
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

410358:MLAB RS06440
gene id: 410358:MLAB_RS06440
uniprot id: A2SST2
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

410358:MLAB RS04860
gene id: 410358:MLAB_RS04860
uniprot id: A2SRY7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

410358:MLAB RS03200
gene id: 410358:MLAB_RS03200
uniprot id: A2SR26
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

410358:MLAB RS07990
gene id: 410358:MLAB_RS07990
uniprot id: A2STL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

410358:MLAB RS05900
gene id: 410358:MLAB_RS05900
uniprot id: A2SSI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Membrane

410358:MLAB RS01460
gene id: 410358:MLAB_RS01460
uniprot id: A2SQ53
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

410358:MLAB RS05990
gene id: 410358:MLAB_RS05990
uniprot id: A2SSJ8
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

410358:MLAB RS07985
gene id: 410358:MLAB_RS07985
uniprot id: A2STL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

410358:MLAB RS01130
gene id: 410358:MLAB_RS01130
uniprot id: A2SPY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

410358:MLAB RS02465
gene id: 410358:MLAB_RS02465
uniprot id: A2SQN5
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS02590
gene id: 410358:MLAB_RS02590
uniprot id: A2SQQ9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

410358:MLAB RS08315
gene id: 410358:MLAB_RS08315
uniprot id: A2STS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

410358:MLAB RS06170
gene id: 410358:MLAB_RS06170
uniprot id: A2SSN2
names: Caution
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

410358:MLAB RS02650
gene id: 410358:MLAB_RS02650
uniprot id: A2SQS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the threonine synthase family. Cysteate synthase subfamily.
messages: Homotrimer.
messages: Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate.

410358:MLAB RS04290
gene id: 410358:MLAB_RS04290
uniprot id: A2SRN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

410358:MLAB RS02330
gene id: 410358:MLAB_RS02330
uniprot id: A2SQK9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

410358:MLAB RS09385
gene id: 410358:MLAB_RS09385
uniprot id: A2SRA7
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS07625
gene id: 410358:MLAB_RS07625
uniprot id: A2STE9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

410358:MLAB RS06615
gene id: 410358:MLAB_RS06615
uniprot id: A2SSW5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

410358:MLAB RS00865
gene id: 410358:MLAB_RS00865
uniprot id: A2SPT5
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

410358:MLAB RS06585
gene id: 410358:MLAB_RS06585
uniprot id: A2SSW0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

410358:MLAB RS05285
gene id: 410358:MLAB_RS05285
uniprot id: A2SS66
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.

410358:MLAB RS08345
gene id: 410358:MLAB_RS08345
uniprot id: A2STT5
names: Caution
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

410358:MLAB RS09435
gene id: 410358:MLAB_RS09435
uniprot id: A2ST54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

410358:MLAB RS06625
gene id: 410358:MLAB_RS06625
uniprot id: A2SSW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

410358:MLAB RS00130
gene id: 410358:MLAB_RS00130
uniprot id: A2SPE8
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

410358:MLAB RS06870
gene id: 410358:MLAB_RS06870
uniprot id: A2ST11
names: Similarity
messages: Belongs to the eIF-2-alpha family.

410358:MLAB RS08690
gene id: 410358:MLAB_RS08690
uniprot id: A2SU00
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

410358:MLAB RS03130
gene id: 410358:MLAB_RS03130
uniprot id: A2SR12
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

410358:MLAB RS02315
gene id: 410358:MLAB_RS02315
uniprot id: A2SQK6
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

410358:MLAB RS08580
gene id: 410358:MLAB_RS08580
uniprot id: A2STX8
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS03075
gene id: 410358:MLAB_RS03075
uniprot id: A2SR02
names: Domain
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.
messages: Involved in DNA damage repair.

410358:MLAB RS00310
gene id: 410358:MLAB_RS00310
uniprot id: A2SPI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

410358:MLAB RS00445
gene id: 410358:MLAB_RS00445
uniprot id: A2SPK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

410358:MLAB RS06985
gene id: 410358:MLAB_RS06985
uniprot id: A2ST30
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

410358:MLAB RS05620
gene id: 410358:MLAB_RS05620
uniprot id: A2SSC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

410358:MLAB RS06140
gene id: 410358:MLAB_RS06140
uniprot id: A2SSM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

410358:MLAB RS03295
gene id: 410358:MLAB_RS03295
uniprot id: A2SR43
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

410358:MLAB RS08360
gene id: 410358:MLAB_RS08360
uniprot id: A2STT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

410358:MLAB RS03555
gene id: 410358:MLAB_RS03555
uniprot id: A2SR93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

410358:MLAB RS07020
gene id: 410358:MLAB_RS07020
uniprot id: A2ST37
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

410358:MLAB RS01055
gene id: 410358:MLAB_RS01055
uniprot id: A2SPX4
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

410358:MLAB RS09240
gene id: 410358:MLAB_RS09240
uniprot id: A2SU98
names: Similarity
messages: Belongs to the UPF0254 family.

410358:MLAB RS08145
gene id: 410358:MLAB_RS08145
uniprot id: A2STP6
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS09105
gene id: 410358:MLAB_RS09105
uniprot id: A2SU74
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

410358:MLAB RS03460
gene id: 410358:MLAB_RS03460
uniprot id: A2SR75
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

410358:MLAB RS00005
gene id: 410358:MLAB_RS00005
uniprot id: A2SPC3
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

410358:MLAB RS07505
gene id: 410358:MLAB_RS07505
uniprot id: A2STC6
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

410358:MLAB RS06660
gene id: 410358:MLAB_RS06660
uniprot id: A2SSX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

410358:MLAB RS08185
gene id: 410358:MLAB_RS08185
uniprot id: A2STQ3
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.

410358:MLAB RS02595
gene id: 410358:MLAB_RS02595
uniprot id: A2SQR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

410358:MLAB RS00905
gene id: 410358:MLAB_RS00905
uniprot id: A2SPU3
names: Cofactor
names: Similarity
messages: Belongs to the desulfoferrodoxin family.
messages: Binds 1 Fe(2+) ion per subunit. The iron ion 2 is coordinated via four histidines and one cysteine residue.
messages: Binds 1 Fe(3+) ion per subunit. The iron ion 1 is coordinated via 4 cysteine residues.

410358:MLAB RS04030
gene id: 410358:MLAB_RS04030
uniprot id: A2SRI4
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

410358:MLAB RS03590
gene id: 410358:MLAB_RS03590
uniprot id: A2SRA0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

410358:MLAB RS09270
gene id: 410358:MLAB_RS09270
uniprot id: A2SUA4
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

410358:MLAB RS03470
gene id: 410358:MLAB_RS03470
uniprot id: A2SR76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

410358:MLAB RS05040
gene id: 410358:MLAB_RS05040
uniprot id: A2SS21
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

410358:MLAB RS00700
gene id: 410358:MLAB_RS00700
uniprot id: A2SPQ4
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

410358:MLAB RS06010
gene id: 410358:MLAB_RS06010
uniprot id: A2SSK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group I subfamily.
messages: Cytoplasm
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

410358:MLAB RS07455
gene id: 410358:MLAB_RS07455
uniprot id: A2STB6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

410358:MLAB RS07525
gene id: 410358:MLAB_RS07525
uniprot id: A2STD0
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

410358:MLAB RS06890
gene id: 410358:MLAB_RS06890
uniprot id: A2ST15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).

410358:MLAB RS04480
gene id: 410358:MLAB_RS04480
uniprot id: A2SRR9
names: Similarity
messages: Belongs to the DtxR/MntR family.

410358:MLAB RS09470
gene id: 410358:MLAB_RS09470
uniprot id: A2STZ7
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS07950
gene id: 410358:MLAB_RS07950
uniprot id: A2STK9
names: Subcellular Location Annotation
messages: Cytoplasm

410358:MLAB RS05255
gene id: 410358:MLAB_RS05255
uniprot id: A2SS61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

410358:MLAB RS03570
gene id: 410358:MLAB_RS03570
uniprot id: A2SR96
names: Similarity
messages: Belongs to the MEMO1 family.

410358:MLAB RS07550
gene id: 410358:MLAB_RS07550
uniprot id: A2STD5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

410358:MLAB RS06080
gene id: 410358:MLAB_RS06080
uniprot id: A2SSL5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

410358:MLAB RS05890
gene id: 410358:MLAB_RS05890
uniprot id: A2SSH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

410358:MLAB RS07130
gene id: 410358:MLAB_RS07130
uniprot id: A2ST56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

410358:MLAB RS05515
gene id: 410358:MLAB_RS05515
uniprot id: A2SSA4
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

410358:MLAB RS04280
gene id: 410358:MLAB_RS04280
uniprot id: A2SRN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

410358:MLAB RS03710
gene id: 410358:MLAB_RS03710
uniprot id: A2SRC2
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

410358:MLAB RS08255
gene id: 410358:MLAB_RS08255
uniprot id: A2STR7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

410358:MLAB RS00625
gene id: 410358:MLAB_RS00625
uniprot id: A2SPN9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

410358:MLAB RS07815
gene id: 410358:MLAB_RS07815
uniprot id: A2STI3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

410358:MLAB RS06820
gene id: 410358:MLAB_RS06820
uniprot id: A2ST02
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

410358:MLAB RS06560
gene id: 410358:MLAB_RS06560
uniprot id: A2SSV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

410358:MLAB RS06065
gene id: 410358:MLAB_RS06065
uniprot id: A2SSL2
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

410358:MLAB RS03810
gene id: 410358:MLAB_RS03810
uniprot id: A2SRE2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

410358:MLAB RS06705
gene id: 410358:MLAB_RS06705
uniprot id: A2SSY1
names: Similarity
messages: Belongs to the peptidase M24B family.

410358:MLAB RS04850
gene id: 410358:MLAB_RS04850
uniprot id: A2SRY5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

410358:MLAB RS03760
gene id: 410358:MLAB_RS03760
uniprot id: A2SRD2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

410358:MLAB RS08005
gene id: 410358:MLAB_RS08005
uniprot id: A2STL9
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

410358:MLAB RS08530
gene id: 410358:MLAB_RS08530
uniprot id: A2STW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

410358:MLAB RS02170
gene id: 410358:MLAB_RS02170
uniprot id: A2SQI2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

410358:MLAB RS05735
gene id: 410358:MLAB_RS05735
uniprot id: A2SSE7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

410358:MLAB RS03445
gene id: 410358:MLAB_RS03445
uniprot id: A2SR72
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

410358:MLAB RS02175
gene id: 410358:MLAB_RS02175
uniprot id: A2SQI3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

410358:MLAB RS03040
gene id: 410358:MLAB_RS03040
uniprot id: A2SQZ6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

410358:MLAB RS01725
gene id: 410358:MLAB_RS01725
uniprot id: A2SQA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

410358:MLAB RS07400
gene id: 410358:MLAB_RS07400
uniprot id: A2STA7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

410358:MLAB RS07645
gene id: 410358:MLAB_RS07645
uniprot id: A2STF3
names: Similarity
messages: Belongs to the UPF0284 family.

410358:MLAB RS04940
gene id: 410358:MLAB_RS04940
uniprot id: A2SS02
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

410358:MLAB RS02080
gene id: 410358:MLAB_RS02080
uniprot id: A2SQG5
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

410358:MLAB RS00555
gene id: 410358:MLAB_RS00555
uniprot id: A2SPM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

410358:MLAB RS04470
gene id: 410358:MLAB_RS04470
uniprot id: A2SRR7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

410358:MLAB RS09050
gene id: 410358:MLAB_RS09050
uniprot id: A2SU64
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS05645
gene id: 410358:MLAB_RS05645
uniprot id: A2SSC9
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

410358:MLAB RS06555
gene id: 410358:MLAB_RS06555
uniprot id: A2SSV4
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

410358:MLAB RS07355
gene id: 410358:MLAB_RS07355
uniprot id: A2ST98
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

410358:MLAB RS00015
gene id: 410358:MLAB_RS00015
uniprot id: A2SPC5
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

410358:MLAB RS00550
gene id: 410358:MLAB_RS00550
uniprot id: A2SPM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

410358:MLAB RS06070
gene id: 410358:MLAB_RS06070
uniprot id: A2SSL3
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

410358:MLAB RS08070
gene id: 410358:MLAB_RS08070
uniprot id: A2STN1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

410358:MLAB RS06270
gene id: 410358:MLAB_RS06270
uniprot id: A2SSQ3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

410358:MLAB RS03390
gene id: 410358:MLAB_RS03390
uniprot id: A2SR62
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

410358:MLAB RS01640
gene id: 410358:MLAB_RS01640
uniprot id: A2SQ84
names: Subunit
messages: Homotetramer.

410358:MLAB RS04545
gene id: 410358:MLAB_RS04545
uniprot id: A2SRS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

410358:MLAB RS03100
gene id: 410358:MLAB_RS03100
uniprot id: A2SR06
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS01960
gene id: 410358:MLAB_RS01960
uniprot id: A2SQE4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

410358:MLAB RS04230
gene id: 410358:MLAB_RS04230
uniprot id: A2SRM1
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

410358:MLAB RS08670
gene id: 410358:MLAB_RS08670
uniprot id: A2STZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

410358:MLAB RS00915
gene id: 410358:MLAB_RS00915
uniprot id: A2SPU5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

410358:MLAB RS02990
gene id: 410358:MLAB_RS02990
uniprot id: A2SQY6
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS06415
gene id: 410358:MLAB_RS06415
uniprot id: A2SSS7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

410358:MLAB RS01045
gene id: 410358:MLAB_RS01045
uniprot id: A2SPX2
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

410358:MLAB RS05360
gene id: 410358:MLAB_RS05360
uniprot id: A2SS75
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

410358:MLAB RS02580
gene id: 410358:MLAB_RS02580
uniprot id: A2SQQ7
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

410358:MLAB RS00675
gene id: 410358:MLAB_RS00675
uniprot id: A2SPP9
names: Similarity
messages: Belongs to the archease family.

410358:MLAB RS08705
gene id: 410358:MLAB_RS08705
uniprot id: A2SU02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

410358:MLAB RS04080
gene id: 410358:MLAB_RS04080
uniprot id: A2SRJ3
names: Similarity
messages: Belongs to the peptidase U62 family.

410358:MLAB RS01255
gene id: 410358:MLAB_RS01255
uniprot id: A2SQ14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

410358:MLAB RS07365
gene id: 410358:MLAB_RS07365
uniprot id: A2STA0
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS00355
gene id: 410358:MLAB_RS00355
uniprot id: A2SPI9
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

410358:MLAB RS01965
gene id: 410358:MLAB_RS01965
uniprot id: A2SQE5
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

410358:MLAB RS08715
gene id: 410358:MLAB_RS08715
uniprot id: A2SU04
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

410358:MLAB RS01935
gene id: 410358:MLAB_RS01935
uniprot id: A2SQD9
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

410358:MLAB RS06700
gene id: 410358:MLAB_RS06700
uniprot id: A2SSY0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

410358:MLAB RS05765
gene id: 410358:MLAB_RS05765
uniprot id: A2SSF3
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

410358:MLAB RS05450
gene id: 410358:MLAB_RS05450
uniprot id: A2SS93
names: Similarity
messages: Belongs to the UPF0210 family.

410358:MLAB RS04170
gene id: 410358:MLAB_RS04170
uniprot id: A2SRL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

410358:MLAB RS03120
gene id: 410358:MLAB_RS03120
uniprot id: A2SR10
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

410358:MLAB RS07195
gene id: 410358:MLAB_RS07195
uniprot id: A2ST69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

410358:MLAB RS02865
gene id: 410358:MLAB_RS02865
uniprot id: A2SQW2
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

410358:MLAB RS02025
gene id: 410358:MLAB_RS02025
uniprot id: A2SQF5
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS06570
gene id: 410358:MLAB_RS06570
uniprot id: A2SSV7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

410358:MLAB RS06765
gene id: 410358:MLAB_RS06765
uniprot id: A2SSZ1
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS02815
gene id: 410358:MLAB_RS02815
uniprot id: A2SQV2
names: Similarity
messages: Belongs to the class-I fumarase family.

410358:MLAB RS04155
gene id: 410358:MLAB_RS04155
uniprot id: A2SRK8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

410358:MLAB RS08550
gene id: 410358:MLAB_RS08550
uniprot id: A2STX3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

410358:MLAB RS00490
gene id: 410358:MLAB_RS00490
uniprot id: A2SPL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

410358:MLAB RS06135
gene id: 410358:MLAB_RS06135
uniprot id: A2SSM6
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Part of the RNA polymerase complex.

410358:MLAB RS03180
gene id: 410358:MLAB_RS03180
uniprot id: A2SR22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
messages: Homodimer.

410358:MLAB RS00510
gene id: 410358:MLAB_RS00510
uniprot id: A2SPL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

410358:MLAB RS01490
gene id: 410358:MLAB_RS01490
uniprot id: A2SQ60
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

410358:MLAB RS03575
gene id: 410358:MLAB_RS03575
uniprot id: A2SR97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

410358:MLAB RS02305
gene id: 410358:MLAB_RS02305
uniprot id: A2SQK4
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

410358:MLAB RS03955
gene id: 410358:MLAB_RS03955
uniprot id: A2SRH0
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

410358:MLAB RS01050
gene id: 410358:MLAB_RS01050
uniprot id: A2SPX3
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

410358:MLAB RS00025
gene id: 410358:MLAB_RS00025
uniprot id: A2SPC7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Requires K(+) for maximal activity.
messages: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.

410358:MLAB RS04995
gene id: 410358:MLAB_RS04995
uniprot id: A2SS12
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

410358:MLAB RS07895
gene id: 410358:MLAB_RS07895
uniprot id: A2STJ7
names: Function
messages: Part of a potassium transport system.

410358:MLAB RS02040
gene id: 410358:MLAB_RS02040
uniprot id: A2SQF8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

410358:MLAB RS07600
gene id: 410358:MLAB_RS07600
uniprot id: A2STE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

410358:MLAB RS05700
gene id: 410358:MLAB_RS05700
uniprot id: A2SSE0
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

410358:MLAB RS01240
gene id: 410358:MLAB_RS01240
uniprot id: A2SQ11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

410358:MLAB RS06340
gene id: 410358:MLAB_RS06340
uniprot id: A2SSR4
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

410358:MLAB RS02870
gene id: 410358:MLAB_RS02870
uniprot id: A2SQW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

410358:MLAB RS08355
gene id: 410358:MLAB_RS08355
uniprot id: A2STT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

410358:MLAB RS05810
gene id: 410358:MLAB_RS05810
uniprot id: A2SSG2
names: Caution
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

410358:MLAB RS05305
gene id: 410358:MLAB_RS05305
uniprot id: A2SS69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

410358:MLAB RS09280
gene id: 410358:MLAB_RS09280
uniprot id: A2SUA6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

410358:MLAB RS00810
gene id: 410358:MLAB_RS00810
uniprot id: A2SPS5
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

410358:MLAB RS02795
gene id: 410358:MLAB_RS02795
uniprot id: A2SQU8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

410358:MLAB RS06610
gene id: 410358:MLAB_RS06610
uniprot id: A2SSW4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

410358:MLAB RS08665
gene id: 410358:MLAB_RS08665
uniprot id: A2STZ5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

410358:MLAB RS02030
gene id: 410358:MLAB_RS02030
uniprot id: A2SQF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

410358:MLAB RS08265
gene id: 410358:MLAB_RS08265
uniprot id: A2STR9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

410358:MLAB RS00560
gene id: 410358:MLAB_RS00560
uniprot id: A2SPM7
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS05705
gene id: 410358:MLAB_RS05705
uniprot id: A2SSE1
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

410358:MLAB RS04745
gene id: 410358:MLAB_RS04745
uniprot id: A2SRW5
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

410358:MLAB RS01885
gene id: 410358:MLAB_RS01885
uniprot id: A2SQD0
names: Similarity
messages: Belongs to the archaeal-type GPI family.

410358:MLAB RS05980
gene id: 410358:MLAB_RS05980
uniprot id: A2SSJ6
names: Function
messages: Catalyzes the synthesis of GMP from XMP.

410358:MLAB RS01165
gene id: 410358:MLAB_RS01165
uniprot id: A2SPZ6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

410358:MLAB RS04405
gene id: 410358:MLAB_RS04405
uniprot id: A2SRQ4
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

410358:MLAB RS07100
gene id: 410358:MLAB_RS07100
uniprot id: A2ST50
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

410358:MLAB RS05585
gene id: 410358:MLAB_RS05585
uniprot id: A2SSB7
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

410358:MLAB RS04275
gene id: 410358:MLAB_RS04275
uniprot id: A2SRN0
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

410358:MLAB RS02715
gene id: 410358:MLAB_RS02715
uniprot id: A2SQT3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

410358:MLAB RS09390
gene id: 410358:MLAB_RS09390
uniprot id: A2SRB8
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS03090
gene id: 410358:MLAB_RS03090
uniprot id: A2SR04
names: Similarity
messages: Belongs to the IMPACT family.

410358:MLAB RS06125
gene id: 410358:MLAB_RS06125
uniprot id: A2SSM4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

410358:MLAB RS02520
gene id: 410358:MLAB_RS02520
uniprot id: A2SQP5
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

410358:MLAB RS03830
gene id: 410358:MLAB_RS03830
uniprot id: A2SRE6
names: Similarity
messages: Belongs to the UPF0251 family.

410358:MLAB RS03415
gene id: 410358:MLAB_RS03415
uniprot id: A2SR65
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

410358:MLAB RS01375
gene id: 410358:MLAB_RS01375
uniprot id: A2SQ37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

410358:MLAB RS03050
gene id: 410358:MLAB_RS03050
uniprot id: A2SQZ8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

410358:MLAB RS06880
gene id: 410358:MLAB_RS06880
uniprot id: A2ST13
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

410358:MLAB RS01195
gene id: 410358:MLAB_RS01195
uniprot id: A2SQ02
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

410358:MLAB RS07620
gene id: 410358:MLAB_RS07620
uniprot id: A2STE8
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS00830
gene id: 410358:MLAB_RS00830
uniprot id: A2SPS9
names: Similarity
messages: Belongs to the P(II) protein family.

410358:MLAB RS05395
gene id: 410358:MLAB_RS05395
uniprot id: A2SS82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

410358:MLAB RS09020
gene id: 410358:MLAB_RS09020
uniprot id: A2SU58
names: Similarity
messages: Belongs to the band 7/mec-2 family.

410358:MLAB RS01335
gene id: 410358:MLAB_RS01335
uniprot id: A2SQ29
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

410358:MLAB RS06535
gene id: 410358:MLAB_RS06535
uniprot id: A2SSV0
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

410358:MLAB RS07305
gene id: 410358:MLAB_RS07305
uniprot id: A2ST88
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

410358:MLAB RS06915
gene id: 410358:MLAB_RS06915
uniprot id: A2ST19
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

410358:MLAB RS06370
gene id: 410358:MLAB_RS06370
uniprot id: A2SSS0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

410358:MLAB RS01360
gene id: 410358:MLAB_RS01360
uniprot id: A2SQ34
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

410358:MLAB RS05025
gene id: 410358:MLAB_RS05025
uniprot id: A2SS18
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS05410
gene id: 410358:MLAB_RS05410
uniprot id: A2SS85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

410358:MLAB RS08765
gene id: 410358:MLAB_RS08765
uniprot id: A2SU14
names: Similarity
messages: Belongs to the TrpF family.

410358:MLAB RS05495
gene id: 410358:MLAB_RS05495
uniprot id: A2SSA0
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

410358:MLAB RS00295
gene id: 410358:MLAB_RS00295
uniprot id: A2SPI0
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

410358:MLAB RS03455
gene id: 410358:MLAB_RS03455
uniprot id: A2SR74
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

410358:MLAB RS06740
gene id: 410358:MLAB_RS06740
uniprot id: A2SSY6
names: Similarity
messages: Belongs to the LarC family.

410358:MLAB RS04845
gene id: 410358:MLAB_RS04845
uniprot id: A2SRY4
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

410358:MLAB RS06100
gene id: 410358:MLAB_RS06100
uniprot id: A2SSL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

410358:MLAB RS04195
gene id: 410358:MLAB_RS04195
uniprot id: A2SRL5
names: Similarity
messages: Belongs to the UPF0107 family.

410358:MLAB RS03450
gene id: 410358:MLAB_RS03450
uniprot id: A2SR73
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

410358:MLAB RS05675
gene id: 410358:MLAB_RS05675
uniprot id: A2SSD5
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

410358:MLAB RS07845
gene id: 410358:MLAB_RS07845
uniprot id: A2STI8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

410358:MLAB RS00930
gene id: 410358:MLAB_RS00930
uniprot id: A2SPU9
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS07850
gene id: 410358:MLAB_RS07850
uniprot id: A2STI9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

410358:MLAB RS02605
gene id: 410358:MLAB_RS02605
uniprot id: A2SQR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

410358:MLAB RS02195
gene id: 410358:MLAB_RS02195
uniprot id: A2SQI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

410358:MLAB RS09190
gene id: 410358:MLAB_RS09190
uniprot id: A2SU89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

410358:MLAB RS02165
gene id: 410358:MLAB_RS02165
uniprot id: A2SQI1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

410358:MLAB RS06475
gene id: 410358:MLAB_RS06475
uniprot id: A2SST9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

410358:MLAB RS05935
gene id: 410358:MLAB_RS05935
uniprot id: A2SSI7
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

410358:MLAB RS05760
gene id: 410358:MLAB_RS05760
uniprot id: A2SSF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

410358:MLAB RS01910
gene id: 410358:MLAB_RS01910
uniprot id: A2SQD5
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

410358:MLAB RS01980
gene id: 410358:MLAB_RS01980
uniprot id: A2SQE8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

410358:MLAB RS05870
gene id: 410358:MLAB_RS05870
uniprot id: A2SSH4
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

410358:MLAB RS00545
gene id: 410358:MLAB_RS00545
uniprot id: A2SPM4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

410358:MLAB RS07125
gene id: 410358:MLAB_RS07125
uniprot id: A2ST55
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

410358:MLAB RS06895
gene id: 410358:MLAB_RS06895
uniprot id: A2ST16
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

410358:MLAB RS07315
gene id: 410358:MLAB_RS07315
uniprot id: A2ST90
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

410358:MLAB RS01005
gene id: 410358:MLAB_RS01005
uniprot id: A2SPW4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

410358:MLAB RS04150
gene id: 410358:MLAB_RS04150
uniprot id: A2SRK7
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

410358:MLAB RS00995
gene id: 410358:MLAB_RS00995
uniprot id: A2SPW2
names: Similarity
messages: Belongs to the Fmt family.

410358:MLAB RS00455
gene id: 410358:MLAB_RS00455
uniprot id: A2SPK7
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

410358:MLAB RS02570
gene id: 410358:MLAB_RS02570
uniprot id: A2SQQ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

410358:MLAB RS01425
gene id: 410358:MLAB_RS01425
uniprot id: A2SQ46
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

410358:MLAB RS03055
gene id: 410358:MLAB_RS03055
uniprot id: A2SQZ9
names: Caution
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

410358:MLAB RS03240
gene id: 410358:MLAB_RS03240
uniprot id: A2SR34
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

410358:MLAB RS04050
gene id: 410358:MLAB_RS04050
uniprot id: A2SRI7
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

410358:MLAB RS02765
gene id: 410358:MLAB_RS02765
uniprot id: A2SQU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

410358:MLAB RS02460
gene id: 410358:MLAB_RS02460
uniprot id: A2SQN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

410358:MLAB RS07830
gene id: 410358:MLAB_RS07830
uniprot id: A2STI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

410358:MLAB RS06600
gene id: 410358:MLAB_RS06600
uniprot id: A2SSW2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

410358:MLAB RS05985
gene id: 410358:MLAB_RS05985
uniprot id: A2SSJ7
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

410358:MLAB RS03730
gene id: 410358:MLAB_RS03730
uniprot id: A2SRC6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

410358:MLAB RS00225
gene id: 410358:MLAB_RS00225
uniprot id: A2SPG6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

410358:MLAB RS06580
gene id: 410358:MLAB_RS06580
uniprot id: A2SSV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

410358:MLAB RS02375
gene id: 410358:MLAB_RS02375
uniprot id: A2SQL7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

410358:MLAB RS06575
gene id: 410358:MLAB_RS06575
uniprot id: A2SSV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

410358:MLAB RS07325
gene id: 410358:MLAB_RS07325
uniprot id: A2ST92
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

410358:MLAB RS03505
gene id: 410358:MLAB_RS03505
uniprot id: A2SR83
names: Similarity
messages: Belongs to the phosphohexose mutase family.

410358:MLAB RS02285
gene id: 410358:MLAB_RS02285
uniprot id: A2SQK1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

410358:MLAB RS08060
gene id: 410358:MLAB_RS08060
uniprot id: A2STM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

410358:MLAB RS06565
gene id: 410358:MLAB_RS06565
uniprot id: A2SSV6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

410358:MLAB RS00890
gene id: 410358:MLAB_RS00890
uniprot id: A2SPU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

410358:MLAB RS05520
gene id: 410358:MLAB_RS05520
uniprot id: A2SSA5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

410358:MLAB RS07920
gene id: 410358:MLAB_RS07920
uniprot id: A2STK2
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS02185
gene id: 410358:MLAB_RS02185
uniprot id: A2SQI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

410358:MLAB RS08965
gene id: 410358:MLAB_RS08965
uniprot id: A2SU47
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS03685
gene id: 410358:MLAB_RS03685
uniprot id: A2SRB7
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS03725
gene id: 410358:MLAB_RS03725
uniprot id: A2SRC5
names: Similarity
messages: Belongs to the acylphosphatase family.

410358:MLAB RS08735
gene id: 410358:MLAB_RS08735
uniprot id: A2SU08
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

410358:MLAB RS09060
gene id: 410358:MLAB_RS09060
uniprot id: A2SU66
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

410358:MLAB RS08080
gene id: 410358:MLAB_RS08080
uniprot id: A2STN3
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

410358:MLAB RS08725
gene id: 410358:MLAB_RS08725
uniprot id: A2SU06
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

410358:MLAB RS06620
gene id: 410358:MLAB_RS06620
uniprot id: A2SSW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

410358:MLAB RS02855
gene id: 410358:MLAB_RS02855
uniprot id: A2SQW0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

410358:MLAB RS08535
gene id: 410358:MLAB_RS08535
uniprot id: A2STX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

410358:MLAB RS08290
gene id: 410358:MLAB_RS08290
uniprot id: A2STS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

410358:MLAB RS08390
gene id: 410358:MLAB_RS08390
uniprot id: A2STU3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

410358:MLAB RS01400
gene id: 410358:MLAB_RS01400
uniprot id: A2SQ42
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

410358:MLAB RS08810
gene id: 410358:MLAB_RS08810
uniprot id: A2SU18
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

410358:MLAB RS00785
gene id: 410358:MLAB_RS00785
uniprot id: A2SPS0
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

410358:MLAB RS07890
gene id: 410358:MLAB_RS07890
uniprot id: A2STJ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

410358:MLAB RS07860
gene id: 410358:MLAB_RS07860
uniprot id: A2STJ1
names: Similarity
messages: Belongs to the PDCD5 family.

410358:MLAB RS06450
gene id: 410358:MLAB_RS06450
uniprot id: A2SST4
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

410358:MLAB RS03740
gene id: 410358:MLAB_RS03740
uniprot id: A2SRC8
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Homodimer.

410358:MLAB RS05685
gene id: 410358:MLAB_RS05685
uniprot id: A2SSD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

410358:MLAB RS04665
gene id: 410358:MLAB_RS04665
uniprot id: A2SRV0
names: Similarity
messages: Belongs to the HepT RNase toxin family.

410358:MLAB RS01925
gene id: 410358:MLAB_RS01925
uniprot id: A2SQD7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

410358:MLAB RS05010
gene id: 410358:MLAB_RS05010
uniprot id: A2SS15
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

410358:MLAB RS02930
gene id: 410358:MLAB_RS02930
uniprot id: A2SQX5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

410358:MLAB RS07605
gene id: 410358:MLAB_RS07605
uniprot id: A2STE5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

410358:MLAB RS02410
gene id: 410358:MLAB_RS02410
uniprot id: A2SQM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

410358:MLAB RS02600
gene id: 410358:MLAB_RS02600
uniprot id: A2SQR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

410358:MLAB RS07265
gene id: 410358:MLAB_RS07265
uniprot id: A2ST80
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

410358:MLAB RS03300
gene id: 410358:MLAB_RS03300
uniprot id: A2SR44
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

410358:MLAB RS08610
gene id: 410358:MLAB_RS08610
uniprot id: A2STY4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).

410358:MLAB RS06085
gene id: 410358:MLAB_RS06085
uniprot id: A2SSL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

410358:MLAB RS05665
gene id: 410358:MLAB_RS05665
uniprot id: A2SSD3
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS04045
gene id: 410358:MLAB_RS04045
uniprot id: A2SRI6
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

410358:MLAB RS07070
gene id: 410358:MLAB_RS07070
uniprot id: A2ST45
names: Similarity
messages: Belongs to the thymidylate kinase family.

410358:MLAB RS02915
gene id: 410358:MLAB_RS02915
uniprot id: A2SQX2
names: Similarity
messages: Belongs to the UPF0288 family.

410358:MLAB RS08980
gene id: 410358:MLAB_RS08980
uniprot id: A2SU50
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS04300
gene id: 410358:MLAB_RS04300
uniprot id: A2SRN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

410358:MLAB RS01825
gene id: 410358:MLAB_RS01825
uniprot id: A2SQB9
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

410358:MLAB RS00525
gene id: 410358:MLAB_RS00525
uniprot id: A2SPM0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

410358:MLAB RS02755
gene id: 410358:MLAB_RS02755
uniprot id: A2SQU1
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

410358:MLAB RS04805
gene id: 410358:MLAB_RS04805
uniprot id: A2SRX6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

410358:MLAB RS05425
gene id: 410358:MLAB_RS05425
uniprot id: A2SS88
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.

410358:MLAB RS08555
gene id: 410358:MLAB_RS08555
uniprot id: A2STX4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

410358:MLAB RS08240
gene id: 410358:MLAB_RS08240
uniprot id: A2STR4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

410358:MLAB RS07115
gene id: 410358:MLAB_RS07115
uniprot id: A2ST53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

410358:MLAB RS00790
gene id: 410358:MLAB_RS00790
uniprot id: A2SPS1
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

410358:MLAB RS08275
gene id: 410358:MLAB_RS08275
uniprot id: A2STS1
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

410358:MLAB RS01125
gene id: 410358:MLAB_RS01125
uniprot id: A2SPY8
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

410358:MLAB RS08330
gene id: 410358:MLAB_RS08330
uniprot id: A2STT2
names: Similarity
messages: Belongs to the catalase family.

410358:MLAB RS04970
gene id: 410358:MLAB_RS04970
uniprot id: A2SS07
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

410358:MLAB RS05615
gene id: 410358:MLAB_RS05615
uniprot id: A2SSC3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

410358:MLAB RS00200
gene id: 410358:MLAB_RS00200
uniprot id: A2SPG1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.

410358:MLAB RS02085
gene id: 410358:MLAB_RS02085
uniprot id: A2SQG6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

410358:MLAB RS00505
gene id: 410358:MLAB_RS00505
uniprot id: A2SPL6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

410358:MLAB RS08285
gene id: 410358:MLAB_RS08285
uniprot id: A2STS3
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

410358:MLAB RS05960
gene id: 410358:MLAB_RS05960
uniprot id: A2SSJ2
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

410358:MLAB RS01280
gene id: 410358:MLAB_RS01280
uniprot id: A2SQ18
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

410358:MLAB RS07335
gene id: 410358:MLAB_RS07335
uniprot id: A2ST94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

410358:MLAB RS07940
gene id: 410358:MLAB_RS07940
uniprot id: A2STK6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

410358:MLAB RS07065
gene id: 410358:MLAB_RS07065
uniprot id: A2ST44
names: Similarity
messages: Belongs to the HisA/HisF family.

410358:MLAB RS04910
gene id: 410358:MLAB_RS04910
uniprot id: A2SRZ6
names: Similarity
messages: Belongs to the UPF0212 family.

410358:MLAB RS03160
gene id: 410358:MLAB_RS03160
uniprot id: A2SR18
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

410358:MLAB RS00520
gene id: 410358:MLAB_RS00520
uniprot id: A2SPL9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

410358:MLAB RS00075
gene id: 410358:MLAB_RS00075
uniprot id: A2SPD7
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

410358:MLAB RS00680
gene id: 410358:MLAB_RS00680
uniprot id: A2SPQ0
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

410358:MLAB RS07185
gene id: 410358:MLAB_RS07185
uniprot id: A2ST67
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

410358:MLAB RS08250
gene id: 410358:MLAB_RS08250
uniprot id: A2STR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

410358:MLAB RS06465
gene id: 410358:MLAB_RS06465
uniprot id: A2SST7
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

410358:MLAB RS02215
gene id: 410358:MLAB_RS02215
uniprot id: A2SQJ1
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS08375
gene id: 410358:MLAB_RS08375
uniprot id: A2STU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

410358:MLAB RS00770
gene id: 410358:MLAB_RS00770
uniprot id: A2SPR7
names: Similarity
messages: Belongs to the ZPR1 family.

410358:MLAB RS08260
gene id: 410358:MLAB_RS08260
uniprot id: A2STR8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

410358:MLAB RS00805
gene id: 410358:MLAB_RS00805
uniprot id: A2SPS4
names: Similarity
messages: Belongs to the OMP decarboxylase family.

410358:MLAB RS07350
gene id: 410358:MLAB_RS07350
uniprot id: A2ST97
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

410358:MLAB RS06445
gene id: 410358:MLAB_RS06445
uniprot id: A2SST3
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

410358:MLAB RS06755
gene id: 410358:MLAB_RS06755
uniprot id: A2SSY9
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS04855
gene id: 410358:MLAB_RS04855
uniprot id: A2SRY6
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

410358:MLAB RS03585
gene id: 410358:MLAB_RS03585
uniprot id: A2SR99
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

410358:MLAB RS07865
gene id: 410358:MLAB_RS07865
uniprot id: A2STJ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

410358:MLAB RS06395
gene id: 410358:MLAB_RS06395
uniprot id: A2SSS5
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

410358:MLAB RS00695
gene id: 410358:MLAB_RS00695
uniprot id: A2SPQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

410358:MLAB RS00435
gene id: 410358:MLAB_RS00435
uniprot id: A2SPK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

410358:MLAB RS01430
gene id: 410358:MLAB_RS01430
uniprot id: A2SQ47
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

410358:MLAB RS06015
gene id: 410358:MLAB_RS06015
uniprot id: A2SSK2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

410358:MLAB RS00410
gene id: 410358:MLAB_RS00410
uniprot id: A2SPJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

410358:MLAB RS03430
gene id: 410358:MLAB_RS03430
uniprot id: A2SR69
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

410358:MLAB RS05055
gene id: 410358:MLAB_RS05055
uniprot id: A2SS24
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS03750
gene id: 410358:MLAB_RS03750
uniprot id: A2SRD0
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS02340
gene id: 410358:MLAB_RS02340
uniprot id: A2SQL1
names: Similarity
messages: Belongs to the pirin family.

410358:MLAB RS05140
gene id: 410358:MLAB_RS05140
uniprot id: A2SS40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

410358:MLAB RS00135
gene id: 410358:MLAB_RS00135
uniprot id: A2SPE9
names: Subcellular Location Annotation
messages: Membrane

410358:MLAB RS01415
gene id: 410358:MLAB_RS01415
uniprot id: A2SQ45
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

410358:MLAB RS01990
gene id: 410358:MLAB_RS01990
uniprot id: A2SQF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

410358:MLAB RS01660
gene id: 410358:MLAB_RS01660
uniprot id: A2SQ88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

410358:MLAB RS02270
gene id: 410358:MLAB_RS02270
uniprot id: A2SQJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

410358:MLAB RS02255
gene id: 410358:MLAB_RS02255
uniprot id: A2SQJ5
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.