406327:MEVAN RS04995
gene id: 406327:MEVAN_RS04995
uniprot id: A6UQV7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

406327:MEVAN RS07750
gene id: 406327:MEVAN_RS07750
uniprot id: A6USC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

406327:MEVAN RS04445
gene id: 406327:MEVAN_RS04445
uniprot id: A6UQK3
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

406327:MEVAN RS02175
gene id: 406327:MEVAN_RS02175
uniprot id: A6UPB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

406327:MEVAN RS03730
gene id: 406327:MEVAN_RS03730
uniprot id: A6UQ65
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

406327:MEVAN RS02380
gene id: 406327:MEVAN_RS02380
uniprot id: A6UPF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
messages: Cell membrane

406327:MEVAN RS06665
gene id: 406327:MEVAN_RS06665
uniprot id: A6URR6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

406327:MEVAN RS05155
gene id: 406327:MEVAN_RS05155
uniprot id: A6UQY9
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

406327:MEVAN RS03850
gene id: 406327:MEVAN_RS03850
uniprot id: A6UQ89
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

406327:MEVAN RS01710
gene id: 406327:MEVAN_RS01710
uniprot id: A6UP19
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

406327:MEVAN RS00035
gene id: 406327:MEVAN_RS00035
uniprot id: A6UN47
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

406327:MEVAN RS03675
gene id: 406327:MEVAN_RS03675
uniprot id: A6UQ54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

406327:MEVAN RS07725
gene id: 406327:MEVAN_RS07725
uniprot id: A6USC3
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS05265
gene id: 406327:MEVAN_RS05265
uniprot id: A6UR08
names: Similarity
messages: Belongs to the MCM family.

406327:MEVAN RS06015
gene id: 406327:MEVAN_RS06015
uniprot id: A6URE5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiX family. CbiXS subfamily.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni-sirohydrochlorin.
messages: Homotetramer; dimer of dimers.

406327:MEVAN RS04790
gene id: 406327:MEVAN_RS04790
uniprot id: A6UQS2
names: Similarity
messages: Belongs to the glutaredoxin family.

406327:MEVAN RS07060
gene id: 406327:MEVAN_RS07060
uniprot id: A6URZ2
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

406327:MEVAN RS03455
gene id: 406327:MEVAN_RS03455
uniprot id: P14247
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

406327:MEVAN RS02580
gene id: 406327:MEVAN_RS02580
uniprot id: A6UPJ1
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

406327:MEVAN RS04670
gene id: 406327:MEVAN_RS04670
uniprot id: A6UQP9
names: Similarity
messages: Belongs to the pyruvate kinase family.

406327:MEVAN RS00885
gene id: 406327:MEVAN_RS00885
uniprot id: A6UNK9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

406327:MEVAN RS01730
gene id: 406327:MEVAN_RS01730
uniprot id: A6UP23
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

406327:MEVAN RS08095
gene id: 406327:MEVAN_RS08095
uniprot id: A6USJ7
names: Subcellular Location Annotation
messages: Cell membrane

406327:MEVAN RS06535
gene id: 406327:MEVAN_RS06535
uniprot id: A6URN9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

406327:MEVAN RS05520
gene id: 406327:MEVAN_RS05520
uniprot id: A6UR59
names: Similarity
messages: Belongs to the P(II) protein family.

406327:MEVAN RS01600
gene id: 406327:MEVAN_RS01600
uniprot id: A6UNZ6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

406327:MEVAN RS05255
gene id: 406327:MEVAN_RS05255
uniprot id: A6UR06
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

406327:MEVAN RS03500
gene id: 406327:MEVAN_RS03500
uniprot id: P14027
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

406327:MEVAN RS02940
gene id: 406327:MEVAN_RS02940
uniprot id: A6UPR3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

406327:MEVAN RS01540
gene id: 406327:MEVAN_RS01540
uniprot id: A6UNY4
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS03015
gene id: 406327:MEVAN_RS03015
uniprot id: A6UPS6
names: Similarity
messages: Belongs to the UPF0200 family.

406327:MEVAN RS06425
gene id: 406327:MEVAN_RS06425
uniprot id: A6URL7
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

406327:MEVAN RS00380
gene id: 406327:MEVAN_RS00380
uniprot id: A6UNB5
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

406327:MEVAN RS03090
gene id: 406327:MEVAN_RS03090
uniprot id: A6UPT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

406327:MEVAN RS04720
gene id: 406327:MEVAN_RS04720
uniprot id: A6UQQ9
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

406327:MEVAN RS01080
gene id: 406327:MEVAN_RS01080
uniprot id: A6UNP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Dps family.
messages: Homododecamer. The 12 identical subunits form a hollow sphere into which the mineral iron core of up to 300 Fe(3+) can be deposited.
messages: Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction.
messages: nucleoid

406327:MEVAN RS06080
gene id: 406327:MEVAN_RS06080
uniprot id: A6URF8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

406327:MEVAN RS00215
gene id: 406327:MEVAN_RS00215
uniprot id: A6UN83
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

406327:MEVAN RS04335
gene id: 406327:MEVAN_RS04335
uniprot id: A6UQI5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

406327:MEVAN RS03495
gene id: 406327:MEVAN_RS03495
uniprot id: A6UQ16
names: Similarity
messages: Belongs to the phosphohexose mutase family.

406327:MEVAN RS02270
gene id: 406327:MEVAN_RS02270
uniprot id: A6UPC9
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS01835
gene id: 406327:MEVAN_RS01835
uniprot id: A6UP44
names: Similarity
messages: Belongs to the thymidylate kinase family.

406327:MEVAN RS01255
gene id: 406327:MEVAN_RS01255
uniprot id: A6UNT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

406327:MEVAN RS07065
gene id: 406327:MEVAN_RS07065
uniprot id: A6URZ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Heterotetramer of 2 HacA and 2 HacB proteins.
messages: Hydro-lyase with broad substrate specificity for cis-unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4-tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4-tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B.

406327:MEVAN RS06000
gene id: 406327:MEVAN_RS06000
uniprot id: A6URE2
names: Similarity
messages: Belongs to the ComB family.

406327:MEVAN RS07560
gene id: 406327:MEVAN_RS07560
uniprot id: A6US89
names: Function
names: Similarity
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.

406327:MEVAN RS04045
gene id: 406327:MEVAN_RS04045
uniprot id: A6UQC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

406327:MEVAN RS06565
gene id: 406327:MEVAN_RS06565
uniprot id: A6URP6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

406327:MEVAN RS07605
gene id: 406327:MEVAN_RS07605
uniprot id: A6US98
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

406327:MEVAN RS00155
gene id: 406327:MEVAN_RS00155
uniprot id: A6UN71
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

406327:MEVAN RS01680
gene id: 406327:MEVAN_RS01680
uniprot id: A6UP13
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

406327:MEVAN RS07965
gene id: 406327:MEVAN_RS07965
uniprot id: A6USH1
names: Similarity
messages: Belongs to the UPF0285 family.

406327:MEVAN RS03860
gene id: 406327:MEVAN_RS03860
uniprot id: A6UQ91
names: Similarity
messages: Belongs to the ZPR1 family.

406327:MEVAN RS07350
gene id: 406327:MEVAN_RS07350
uniprot id: A6US48
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

406327:MEVAN RS05775
gene id: 406327:MEVAN_RS05775
uniprot id: A6URA0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

406327:MEVAN RS06255
gene id: 406327:MEVAN_RS06255
uniprot id: A6URI7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

406327:MEVAN RS05655
gene id: 406327:MEVAN_RS05655
uniprot id: A6UR84
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

406327:MEVAN RS06685
gene id: 406327:MEVAN_RS06685
uniprot id: A6URS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

406327:MEVAN RS00710
gene id: 406327:MEVAN_RS00710
uniprot id: A6UNH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

406327:MEVAN RS05160
gene id: 406327:MEVAN_RS05160
uniprot id: A6UQZ0
names: Similarity
messages: Belongs to the eIF-2-alpha family.

406327:MEVAN RS03160
gene id: 406327:MEVAN_RS03160
uniprot id: A6UPV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

406327:MEVAN RS05475
gene id: 406327:MEVAN_RS05475
uniprot id: A6UR50
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

406327:MEVAN RS05470
gene id: 406327:MEVAN_RS05470
uniprot id: A6UR49
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: Consists of two subunits, CofG and CofH.

406327:MEVAN RS08220
gene id: 406327:MEVAN_RS08220
uniprot id: A6USM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

406327:MEVAN RS01100
gene id: 406327:MEVAN_RS01100
uniprot id: A6UNQ1
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine.

406327:MEVAN RS07985
gene id: 406327:MEVAN_RS07985
uniprot id: A6USH5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

406327:MEVAN RS05205
gene id: 406327:MEVAN_RS05205
uniprot id: A6UQZ9
names: Similarity
messages: Belongs to the HMD family.

406327:MEVAN RS07370
gene id: 406327:MEVAN_RS07370
uniprot id: A6US52
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

406327:MEVAN RS05395
gene id: 406327:MEVAN_RS05395
uniprot id: A6UR19
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

406327:MEVAN RS00330
gene id: 406327:MEVAN_RS00330
uniprot id: A6UNA5
names: Similarity
messages: Belongs to the P(II) protein family.

406327:MEVAN RS03795
gene id: 406327:MEVAN_RS03795
uniprot id: A6UQ78
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

406327:MEVAN RS06240
gene id: 406327:MEVAN_RS06240
uniprot id: A6URI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

406327:MEVAN RS01980
gene id: 406327:MEVAN_RS01980
uniprot id: A6UP71
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Homodimer.

406327:MEVAN RS07780
gene id: 406327:MEVAN_RS07780
uniprot id: A6USD4
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

406327:MEVAN RS00255
gene id: 406327:MEVAN_RS00255
uniprot id: A6UN91
names: Similarity
messages: Belongs to the HMBS family.

406327:MEVAN RS01930
gene id: 406327:MEVAN_RS01930
uniprot id: A6UP63
names: Function
names: Similarity
messages: Belongs to the HdrB family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).

406327:MEVAN RS01120
gene id: 406327:MEVAN_RS01120
uniprot id: A6UNQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

406327:MEVAN RS08680
gene id: 406327:MEVAN_RS08680
uniprot id: A6USV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

406327:MEVAN RS03720
gene id: 406327:MEVAN_RS03720
uniprot id: A6UQ63
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

406327:MEVAN RS03565
gene id: 406327:MEVAN_RS03565
uniprot id: A6UQ31
names: Similarity
messages: Belongs to the MEMO1 family.

406327:MEVAN RS04030
gene id: 406327:MEVAN_RS04030
uniprot id: A6UQC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

406327:MEVAN RS06120
gene id: 406327:MEVAN_RS06120
uniprot id: A6URG5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

406327:MEVAN RS04385
gene id: 406327:MEVAN_RS04385
uniprot id: A6UQJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

406327:MEVAN RS01590
gene id: 406327:MEVAN_RS01590
uniprot id: A6UNZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhD family.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex.

406327:MEVAN RS08655
gene id: 406327:MEVAN_RS08655
uniprot id: A6USV4
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

406327:MEVAN RS08555
gene id: 406327:MEVAN_RS08555
uniprot id: A6UST4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

406327:MEVAN RS02565
gene id: 406327:MEVAN_RS02565
uniprot id: A6UPI8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aldolase class II family. AraD/FucA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the biosynthesis of the coenzyme F420 which requires phospholactate produced via the aldol cleavage of L-fuculose 1-phosphate and the NAD(+)-dependent oxidation of (S)-lactaldehyde. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and S-lactaldehyde.

406327:MEVAN RS00440
gene id: 406327:MEVAN_RS00440
uniprot id: A6UNC7
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

406327:MEVAN RS08155
gene id: 406327:MEVAN_RS08155
uniprot id: A6USK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

406327:MEVAN RS01250
gene id: 406327:MEVAN_RS01250
uniprot id: A6UNT1
names: Similarity
messages: Belongs to the AOR/FOR family.

406327:MEVAN RS01265
gene id: 406327:MEVAN_RS01265
uniprot id: A6UNT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

406327:MEVAN RS03590
gene id: 406327:MEVAN_RS03590
uniprot id: A6UQ37
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

406327:MEVAN RS00150
gene id: 406327:MEVAN_RS00150
uniprot id: A6UN70
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

406327:MEVAN RS07450
gene id: 406327:MEVAN_RS07450
uniprot id: A6US67
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.

406327:MEVAN RS06675
gene id: 406327:MEVAN_RS06675
uniprot id: A6URR8
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

406327:MEVAN RS04495
gene id: 406327:MEVAN_RS04495
uniprot id: A6UQL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MtrH family.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

406327:MEVAN RS00575
gene id: 406327:MEVAN_RS00575
uniprot id: A6UNF2
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS01105
gene id: 406327:MEVAN_RS01105
uniprot id: A6UNQ2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

406327:MEVAN RS06815
gene id: 406327:MEVAN_RS06815
uniprot id: A6URU6
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

406327:MEVAN RS01355
gene id: 406327:MEVAN_RS01355
uniprot id: A6UNV1
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

406327:MEVAN RS02540
gene id: 406327:MEVAN_RS02540
uniprot id: A6UPI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

406327:MEVAN RS07840
gene id: 406327:MEVAN_RS07840
uniprot id: A6USE6
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

406327:MEVAN RS07585
gene id: 406327:MEVAN_RS07585
uniprot id: A6US94
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS07375
gene id: 406327:MEVAN_RS07375
uniprot id: A6US53
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Part of the 30S ribosomal subunit.

406327:MEVAN RS06145
gene id: 406327:MEVAN_RS06145
uniprot id: A6URG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0104 family.
messages: Membrane

406327:MEVAN RS03750
gene id: 406327:MEVAN_RS03750
uniprot id: A6UQ69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

406327:MEVAN RS01200
gene id: 406327:MEVAN_RS01200
uniprot id: A6UNS0
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

406327:MEVAN RS01585
gene id: 406327:MEVAN_RS01585
uniprot id: A6UNZ3
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).

406327:MEVAN RS06400
gene id: 406327:MEVAN_RS06400
uniprot id: A6URL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

406327:MEVAN RS03915
gene id: 406327:MEVAN_RS03915
uniprot id: A6UQA2
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS02025
gene id: 406327:MEVAN_RS02025
uniprot id: A6UP80
names: Similarity
messages: Belongs to the UPF0201 family.

406327:MEVAN RS04845
gene id: 406327:MEVAN_RS04845
uniprot id: A6UQT3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

406327:MEVAN RS04480
gene id: 406327:MEVAN_RS04480
uniprot id: A6UQL0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

406327:MEVAN RS05850
gene id: 406327:MEVAN_RS05850
uniprot id: A6URB5
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

406327:MEVAN RS06350
gene id: 406327:MEVAN_RS06350
uniprot id: A6URK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm

406327:MEVAN RS06600
gene id: 406327:MEVAN_RS06600
uniprot id: A6URQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

406327:MEVAN RS08650
gene id: 406327:MEVAN_RS08650
uniprot id: A6USV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

406327:MEVAN RS03735
gene id: 406327:MEVAN_RS03735
uniprot id: A6UQ66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

406327:MEVAN RS07920
gene id: 406327:MEVAN_RS07920
uniprot id: A6USG2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

406327:MEVAN RS03255
gene id: 406327:MEVAN_RS03255
uniprot id: A6UPW9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

406327:MEVAN RS07470
gene id: 406327:MEVAN_RS07470
uniprot id: A6US71
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

406327:MEVAN RS01155
gene id: 406327:MEVAN_RS01155
uniprot id: A6UNR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

406327:MEVAN RS05825
gene id: 406327:MEVAN_RS05825
uniprot id: A6URB0
names: Function
names: Similarity
messages: Belongs to the HMD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

406327:MEVAN RS02405
gene id: 406327:MEVAN_RS02405
uniprot id: A6UPF6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

406327:MEVAN RS06900
gene id: 406327:MEVAN_RS06900
uniprot id: A6URW3
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

406327:MEVAN RS06105
gene id: 406327:MEVAN_RS06105
uniprot id: A6URG2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).

406327:MEVAN RS07785
gene id: 406327:MEVAN_RS07785
uniprot id: A6USD5
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS02660
gene id: 406327:MEVAN_RS02660
uniprot id: A6UPK7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

406327:MEVAN RS05510
gene id: 406327:MEVAN_RS05510
uniprot id: A6UR57
names: Similarity
messages: Belongs to the P(II) protein family.

406327:MEVAN RS03780
gene id: 406327:MEVAN_RS03780
uniprot id: A6UQ75
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS07165
gene id: 406327:MEVAN_RS07165
uniprot id: A6US11
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

406327:MEVAN RS07850
gene id: 406327:MEVAN_RS07850
uniprot id: A6USE8
names: Similarity
messages: Belongs to the UPF0305 family.

406327:MEVAN RS06945
gene id: 406327:MEVAN_RS06945
uniprot id: A6URX2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

406327:MEVAN RS00365
gene id: 406327:MEVAN_RS00365
uniprot id: A6UNB2
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

406327:MEVAN RS04775
gene id: 406327:MEVAN_RS04775
uniprot id: A6UQS0
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS02570
gene id: 406327:MEVAN_RS02570
uniprot id: A6UPI9
names: Similarity
messages: Belongs to the UPF0147 family.

406327:MEVAN RS00425
gene id: 406327:MEVAN_RS00425
uniprot id: A6UNC4
names: Similarity
messages: Belongs to the HsdR family.

406327:MEVAN RS04450
gene id: 406327:MEVAN_RS04450
uniprot id: A6UQK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Cytoplasm
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

406327:MEVAN RS03715
gene id: 406327:MEVAN_RS03715
uniprot id: A6UQ62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

406327:MEVAN RS03460
gene id: 406327:MEVAN_RS03460
uniprot id: P14025
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

406327:MEVAN RS00355
gene id: 406327:MEVAN_RS00355
uniprot id: A6UNB0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HdrA family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

406327:MEVAN RS08085
gene id: 406327:MEVAN_RS08085
uniprot id: A6USJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

406327:MEVAN RS01550
gene id: 406327:MEVAN_RS01550
uniprot id: A6UNY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

406327:MEVAN RS04680
gene id: 406327:MEVAN_RS04680
uniprot id: A6UQQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

406327:MEVAN RS03855
gene id: 406327:MEVAN_RS03855
uniprot id: A6UQ90
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

406327:MEVAN RS08345
gene id: 406327:MEVAN_RS08345
uniprot id: A6USP4
names: Similarity
messages: Belongs to the UPF0145 family.

406327:MEVAN RS06865
gene id: 406327:MEVAN_RS06865
uniprot id: A6URV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

406327:MEVAN RS01685
gene id: 406327:MEVAN_RS01685
uniprot id: A6UP14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

406327:MEVAN RS08190
gene id: 406327:MEVAN_RS08190
uniprot id: A6USL4
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.

406327:MEVAN RS07600
gene id: 406327:MEVAN_RS07600
uniprot id: A6US97
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

406327:MEVAN RS06020
gene id: 406327:MEVAN_RS06020
uniprot id: A6URE6
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS06340
gene id: 406327:MEVAN_RS06340
uniprot id: A6URK1
names: Subcellular Location Annotation
messages: Cell membrane

406327:MEVAN RS05865
gene id: 406327:MEVAN_RS05865
uniprot id: A6URB8
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

406327:MEVAN RS04855
gene id: 406327:MEVAN_RS04855
uniprot id: A6UQT5
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.

406327:MEVAN RS05555
gene id: 406327:MEVAN_RS05555
uniprot id: A6UR64
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

406327:MEVAN RS07110
gene id: 406327:MEVAN_RS07110
uniprot id: A6US00
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

406327:MEVAN RS04485
gene id: 406327:MEVAN_RS04485
uniprot id: A6UQL1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

406327:MEVAN RS06750
gene id: 406327:MEVAN_RS06750
uniprot id: A6URT3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

406327:MEVAN RS07185
gene id: 406327:MEVAN_RS07185
uniprot id: A6US15
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

406327:MEVAN RS02700
gene id: 406327:MEVAN_RS02700
uniprot id: A6UPL5
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

406327:MEVAN RS04595
gene id: 406327:MEVAN_RS04595
uniprot id: A6UQN4
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

406327:MEVAN RS04905
gene id: 406327:MEVAN_RS04905
uniprot id: A6UQT9
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

406327:MEVAN RS03615
gene id: 406327:MEVAN_RS03615
uniprot id: A6UQ42
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

406327:MEVAN RS04055
gene id: 406327:MEVAN_RS04055
uniprot id: A6UQC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

406327:MEVAN RS06180
gene id: 406327:MEVAN_RS06180
uniprot id: A6URH2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).

406327:MEVAN RS07315
gene id: 406327:MEVAN_RS07315
uniprot id: A6US41
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

406327:MEVAN RS03520
gene id: 406327:MEVAN_RS03520
uniprot id: A6UQ21
names: Similarity
messages: Belongs to the UPF0252 family.

406327:MEVAN RS05685
gene id: 406327:MEVAN_RS05685
uniprot id: A6UR90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

406327:MEVAN RS06560
gene id: 406327:MEVAN_RS06560
uniprot id: A6URP5
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

406327:MEVAN RS08310
gene id: 406327:MEVAN_RS08310
uniprot id: A6USN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

406327:MEVAN RS05930
gene id: 406327:MEVAN_RS05930
uniprot id: A6URC9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-109 inactivates the nitrogenase reductase and regulates nitrogenase activity.

406327:MEVAN RS07555
gene id: 406327:MEVAN_RS07555
uniprot id: A6US88
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS03505
gene id: 406327:MEVAN_RS03505
uniprot id: A6UQ18
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

406327:MEVAN RS01875
gene id: 406327:MEVAN_RS01875
uniprot id: A6UP52
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

406327:MEVAN RS02640
gene id: 406327:MEVAN_RS02640
uniprot id: A6UPK3
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

406327:MEVAN RS06955
gene id: 406327:MEVAN_RS06955
uniprot id: A6URX4
names: Similarity
messages: Belongs to the UPF0284 family.

406327:MEVAN RS07650
gene id: 406327:MEVAN_RS07650
uniprot id: A6USA8
names: Similarity
messages: Belongs to the alpha-acetolactate decarboxylase family.

406327:MEVAN RS01910
gene id: 406327:MEVAN_RS01910
uniprot id: A6UP59
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

406327:MEVAN RS02285
gene id: 406327:MEVAN_RS02285
uniprot id: A6UPD2
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

406327:MEVAN RS03370
gene id: 406327:MEVAN_RS03370
uniprot id: A6UPZ1
names: Similarity
messages: Belongs to the MtxX family.

406327:MEVAN RS05385
gene id: 406327:MEVAN_RS05385
uniprot id: A6UR17
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

406327:MEVAN RS02015
gene id: 406327:MEVAN_RS02015
uniprot id: A6UP78
names: Similarity
messages: Belongs to the peptidase S49 family.

406327:MEVAN RS05235
gene id: 406327:MEVAN_RS05235
uniprot id: A6UR05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

406327:MEVAN RS03365
gene id: 406327:MEVAN_RS03365
uniprot id: A6UPZ0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

406327:MEVAN RS02820
gene id: 406327:MEVAN_RS02820
uniprot id: A6UPN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

406327:MEVAN RS06110
gene id: 406327:MEVAN_RS06110
uniprot id: A6URG3
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

406327:MEVAN RS06715
gene id: 406327:MEVAN_RS06715
uniprot id: A6URS6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

406327:MEVAN RS01965
gene id: 406327:MEVAN_RS01965
uniprot id: A6UP68
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

406327:MEVAN RS03375
gene id: 406327:MEVAN_RS03375
uniprot id: A6UPZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm

406327:MEVAN RS06515
gene id: 406327:MEVAN_RS06515
uniprot id: A6URN5
names: Function
messages: Probably involved in the biogenesis of the ribosome.

406327:MEVAN RS04200
gene id: 406327:MEVAN_RS04200
uniprot id: A6UQF8
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

406327:MEVAN RS08080
gene id: 406327:MEVAN_RS08080
uniprot id: A6USJ4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

406327:MEVAN RS03450
gene id: 406327:MEVAN_RS03450
uniprot id: P41556
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: Part of the RNA polymerase complex.

406327:MEVAN RS01115
gene id: 406327:MEVAN_RS01115
uniprot id: A6UNQ4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

406327:MEVAN RS07405
gene id: 406327:MEVAN_RS07405
uniprot id: A6US59
names: Similarity
messages: Belongs to the peptidase C56 family.

406327:MEVAN RS08580
gene id: 406327:MEVAN_RS08580
uniprot id: A6UST9
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS03745
gene id: 406327:MEVAN_RS03745
uniprot id: A6UQ68
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS07005
gene id: 406327:MEVAN_RS07005
uniprot id: A6URY1
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

406327:MEVAN RS05960
gene id: 406327:MEVAN_RS05960
uniprot id: A6URD4
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

406327:MEVAN RS08645
gene id: 406327:MEVAN_RS08645
uniprot id: A6USV2
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS03345
gene id: 406327:MEVAN_RS03345
uniprot id: A6UPY6
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

406327:MEVAN RS02050
gene id: 406327:MEVAN_RS02050
uniprot id: A6UP85
names: Function
names: Similarity
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP-GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1-P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcNAc and pyrophosphate (By similarity).
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

406327:MEVAN RS00920
gene id: 406327:MEVAN_RS00920
uniprot id: A6UNL6
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

406327:MEVAN RS05050
gene id: 406327:MEVAN_RS05050
uniprot id: A6UQW8
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS03020
gene id: 406327:MEVAN_RS03020
uniprot id: A6UPS7
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS03445
gene id: 406327:MEVAN_RS03445
uniprot id: P41557
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Binds 1 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.
messages: Part of the RNA polymerase complex.

406327:MEVAN RS01285
gene id: 406327:MEVAN_RS01285
uniprot id: A6UNT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

406327:MEVAN RS08240
gene id: 406327:MEVAN_RS08240
uniprot id: A6USM4
names: Subcellular Location Annotation
messages: Cell membrane

406327:MEVAN RS04435
gene id: 406327:MEVAN_RS04435
uniprot id: A6UQK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Cytoplasm
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

406327:MEVAN RS01885
gene id: 406327:MEVAN_RS01885
uniprot id: A6UP54
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

406327:MEVAN RS07485
gene id: 406327:MEVAN_RS07485
uniprot id: A6US74
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

406327:MEVAN RS04810
gene id: 406327:MEVAN_RS04810
uniprot id: A6UQS6
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

406327:MEVAN RS03480
gene id: 406327:MEVAN_RS03480
uniprot id: P09604
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
messages: Cytoplasm

406327:MEVAN RS04540
gene id: 406327:MEVAN_RS04540
uniprot id: A6UQM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

406327:MEVAN RS02000
gene id: 406327:MEVAN_RS02000
uniprot id: A6UP75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

406327:MEVAN RS05645
gene id: 406327:MEVAN_RS05645
uniprot id: A6UR82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

406327:MEVAN RS05455
gene id: 406327:MEVAN_RS05455
uniprot id: A6UR46
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

406327:MEVAN RS04560
gene id: 406327:MEVAN_RS04560
uniprot id: A6UQM7
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

406327:MEVAN RS05980
gene id: 406327:MEVAN_RS05980
uniprot id: A6URD8
names: Similarity
messages: Belongs to the PDCD5 family.

406327:MEVAN RS07545
gene id: 406327:MEVAN_RS07545
uniprot id: A6US86
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

406327:MEVAN RS05845
gene id: 406327:MEVAN_RS05845
uniprot id: A6URB4
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.

406327:MEVAN RS07845
gene id: 406327:MEVAN_RS07845
uniprot id: A6USE7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

406327:MEVAN RS00415
gene id: 406327:MEVAN_RS00415
uniprot id: A6UNC2
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

406327:MEVAN RS00595
gene id: 406327:MEVAN_RS00595
uniprot id: A6UNF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

406327:MEVAN RS03115
gene id: 406327:MEVAN_RS03115
uniprot id: A6UPU3
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

406327:MEVAN RS06085
gene id: 406327:MEVAN_RS06085
uniprot id: A6URF9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

406327:MEVAN RS03705
gene id: 406327:MEVAN_RS03705
uniprot id: A6UQ60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

406327:MEVAN RS00170
gene id: 406327:MEVAN_RS00170
uniprot id: A6UN74
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS03825
gene id: 406327:MEVAN_RS03825
uniprot id: A6UQ84
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

406327:MEVAN RS01790
gene id: 406327:MEVAN_RS01790
uniprot id: A6UP35
names: Similarity
messages: Belongs to the MCM family.

406327:MEVAN RS05295
gene id: 406327:MEVAN_RS05295
uniprot id: A6UR14
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

406327:MEVAN RS05410
gene id: 406327:MEVAN_RS05410
uniprot id: A6UR37
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

406327:MEVAN RS03435
gene id: 406327:MEVAN_RS03435
uniprot id: P41559
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

406327:MEVAN RS07765
gene id: 406327:MEVAN_RS07765
uniprot id: A6USD1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

406327:MEVAN RS00665
gene id: 406327:MEVAN_RS00665
uniprot id: A6UNG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

406327:MEVAN RS01095
gene id: 406327:MEVAN_RS01095
uniprot id: A6UNQ0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

406327:MEVAN RS03635
gene id: 406327:MEVAN_RS03635
uniprot id: A6UQ46
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

406327:MEVAN RS08700
gene id: 406327:MEVAN_RS08700
uniprot id: A6USW3
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

406327:MEVAN RS00470
gene id: 406327:MEVAN_RS00470
uniprot id: A6UND2
names: Similarity
messages: Belongs to the UPF0252 family.

406327:MEVAN RS06185
gene id: 406327:MEVAN_RS06185
uniprot id: A6URH3
names: Similarity
messages: Belongs to the AAA ATPase family.

406327:MEVAN RS06890
gene id: 406327:MEVAN_RS06890
uniprot id: A6URW1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

406327:MEVAN RS02435
gene id: 406327:MEVAN_RS02435
uniprot id: A6UPG2
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

406327:MEVAN RS05610
gene id: 406327:MEVAN_RS05610
uniprot id: A6UR75
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

406327:MEVAN RS01075
gene id: 406327:MEVAN_RS01075
uniprot id: A6UNP6
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS00315
gene id: 406327:MEVAN_RS00315
uniprot id: A6UNA2
names: Function
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).

406327:MEVAN RS05855
gene id: 406327:MEVAN_RS05855
uniprot id: A6URB6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

406327:MEVAN RS03810
gene id: 406327:MEVAN_RS03810
uniprot id: A6UQ81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

406327:MEVAN RS02320
gene id: 406327:MEVAN_RS02320
uniprot id: A6UPD9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers.

406327:MEVAN RS07010
gene id: 406327:MEVAN_RS07010
uniprot id: A6URY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

406327:MEVAN RS03260
gene id: 406327:MEVAN_RS03260
uniprot id: A6UPX0
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

406327:MEVAN RS03150
gene id: 406327:MEVAN_RS03150
uniprot id: A6UPV0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

406327:MEVAN RS03265
gene id: 406327:MEVAN_RS03265
uniprot id: A6UPX1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

406327:MEVAN RS04475
gene id: 406327:MEVAN_RS04475
uniprot id: A6UQK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

406327:MEVAN RS07240
gene id: 406327:MEVAN_RS07240
uniprot id: A6US26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

406327:MEVAN RS00130
gene id: 406327:MEVAN_RS00130
uniprot id: A6UN66
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e. capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

406327:MEVAN RS07150
gene id: 406327:MEVAN_RS07150
uniprot id: A6US08
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

406327:MEVAN RS03290
gene id: 406327:MEVAN_RS03290
uniprot id: A6UPX5
names: Similarity
messages: Belongs to the HupF/HypC family.

406327:MEVAN RS04000
gene id: 406327:MEVAN_RS04000
uniprot id: A6UQB8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

406327:MEVAN RS02355
gene id: 406327:MEVAN_RS02355
uniprot id: A6UPE6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

406327:MEVAN RS05545
gene id: 406327:MEVAN_RS05545
uniprot id: A6UR62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).

406327:MEVAN RS01880
gene id: 406327:MEVAN_RS01880
uniprot id: A6UP53
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

406327:MEVAN RS04705
gene id: 406327:MEVAN_RS04705
uniprot id: A6UQQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

406327:MEVAN RS05445
gene id: 406327:MEVAN_RS05445
uniprot id: A6UR44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

406327:MEVAN RS04395
gene id: 406327:MEVAN_RS04395
uniprot id: A6UQJ5
names: Similarity
messages: Belongs to the class-I fumarase family.

406327:MEVAN RS03185
gene id: 406327:MEVAN_RS03185
uniprot id: A6UPV7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

406327:MEVAN RS00320
gene id: 406327:MEVAN_RS00320
uniprot id: A6UNA3
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

406327:MEVAN RS00220
gene id: 406327:MEVAN_RS00220
uniprot id: A6UN84
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily.
messages: Binds 1 Zn(2+) ion per subunit. This ion is coordinated with 2 cysteines, 1 glutamate and a water molecule that dissociates from the zinc ion to allow the coordination of the amino group of the serine substrate, which is essential for catalysis.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is presumably involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer.

406327:MEVAN RS04230
gene id: 406327:MEVAN_RS04230
uniprot id: A6UQG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

406327:MEVAN RS07565
gene id: 406327:MEVAN_RS07565
uniprot id: A6US90
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

406327:MEVAN RS05805
gene id: 406327:MEVAN_RS05805
uniprot id: A6URA6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

406327:MEVAN RS01805
gene id: 406327:MEVAN_RS01805
uniprot id: A6UP38
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

406327:MEVAN RS06415
gene id: 406327:MEVAN_RS06415
uniprot id: A6URL5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

406327:MEVAN RS04460
gene id: 406327:MEVAN_RS04460
uniprot id: A6UQK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

406327:MEVAN RS07680
gene id: 406327:MEVAN_RS07680
uniprot id: A6USB4
names: Similarity
messages: Belongs to the UPF0251 family.

406327:MEVAN RS03695
gene id: 406327:MEVAN_RS03695
uniprot id: A6UQ58
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

406327:MEVAN RS02705
gene id: 406327:MEVAN_RS02705
uniprot id: A6UPL6
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

406327:MEVAN RS01450
gene id: 406327:MEVAN_RS01450
uniprot id: A6UNW7
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS02735
gene id: 406327:MEVAN_RS02735
uniprot id: A6UPM2
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

406327:MEVAN RS05490
gene id: 406327:MEVAN_RS05490
uniprot id: A6UR53
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

406327:MEVAN RS03485
gene id: 406327:MEVAN_RS03485
uniprot id: A6UQ14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

406327:MEVAN RS01715
gene id: 406327:MEVAN_RS01715
uniprot id: A6UP20
names: Similarity
messages: Belongs to the TrpC family.

406327:MEVAN RS03765
gene id: 406327:MEVAN_RS03765
uniprot id: A6UQ72
names: Similarity
messages: Belongs to the UPF0210 family.

406327:MEVAN RS05040
gene id: 406327:MEVAN_RS05040
uniprot id: A6UQW6
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS02245
gene id: 406327:MEVAN_RS02245
uniprot id: A6UPC4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

406327:MEVAN RS04700
gene id: 406327:MEVAN_RS04700
uniprot id: A6UQQ5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

406327:MEVAN RS06855
gene id: 406327:MEVAN_RS06855
uniprot id: A6URV4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.

406327:MEVAN RS01300
gene id: 406327:MEVAN_RS01300
uniprot id: A6UNU1
names: Similarity
messages: Belongs to the UPF0254 family.

406327:MEVAN RS07950
gene id: 406327:MEVAN_RS07950
uniprot id: A6USG8
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

406327:MEVAN RS06935
gene id: 406327:MEVAN_RS06935
uniprot id: A6URX0
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

406327:MEVAN RS01160
gene id: 406327:MEVAN_RS01160
uniprot id: A6UNR3
names: Similarity
messages: Belongs to the GroES chaperonin family.

406327:MEVAN RS03440
gene id: 406327:MEVAN_RS03440
uniprot id: P41558
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. The Rpo2 subunit (Rpo2N and Rpo2C in this organism) is implicated in DNA promoter recognition and in nucleotide binding.
messages: Part of the RNA polymerase complex.

406327:MEVAN RS03690
gene id: 406327:MEVAN_RS03690
uniprot id: A6UQ57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

406327:MEVAN RS07955
gene id: 406327:MEVAN_RS07955
uniprot id: A6USG9
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS05770
gene id: 406327:MEVAN_RS05770
uniprot id: A6UR99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

406327:MEVAN RS01525
gene id: 406327:MEVAN_RS01525
uniprot id: A6UNY1
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

406327:MEVAN RS02040
gene id: 406327:MEVAN_RS02040
uniprot id: A6UP83
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

406327:MEVAN RS00725
gene id: 406327:MEVAN_RS00725
uniprot id: A6UNH9
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS06090
gene id: 406327:MEVAN_RS06090
uniprot id: A6URG0
names: Similarity
messages: Belongs to the DMRL synthase family.

406327:MEVAN RS08120
gene id: 406327:MEVAN_RS08120
uniprot id: A6USK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

406327:MEVAN RS05180
gene id: 406327:MEVAN_RS05180
uniprot id: A6UQZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

406327:MEVAN RS01635
gene id: 406327:MEVAN_RS01635
uniprot id: A6UP03
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

406327:MEVAN RS02135
gene id: 406327:MEVAN_RS02135
uniprot id: A6UPA2
names: Similarity
messages: Belongs to the UDPGP type 2 family.

406327:MEVAN RS01130
gene id: 406327:MEVAN_RS01130
uniprot id: A6UNQ7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

406327:MEVAN RS06710
gene id: 406327:MEVAN_RS06710
uniprot id: A6URS5
names: Similarity
messages: Belongs to the HypD family.

406327:MEVAN RS04255
gene id: 406327:MEVAN_RS04255
uniprot id: A6UQG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0104 family.
messages: Membrane

406327:MEVAN RS08710
gene id: 406327:MEVAN_RS08710
uniprot id: A6USW5
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

406327:MEVAN RS07815
gene id: 406327:MEVAN_RS07815
uniprot id: A6USE1
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

406327:MEVAN RS07360
gene id: 406327:MEVAN_RS07360
uniprot id: A6US50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

406327:MEVAN RS03400
gene id: 406327:MEVAN_RS03400
uniprot id: A6UPZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.

406327:MEVAN RS04070
gene id: 406327:MEVAN_RS04070
uniprot id: A6UQD2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

406327:MEVAN RS04060
gene id: 406327:MEVAN_RS04060
uniprot id: A6UQD0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family.
messages: Homotetramer.
messages: Involved in F420 biosynthesis through the oxidation of lactaldehyde to lactate.

406327:MEVAN RS04375
gene id: 406327:MEVAN_RS04375
uniprot id: A6UQJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

406327:MEVAN RS05895
gene id: 406327:MEVAN_RS05895
uniprot id: A6URC2
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

406327:MEVAN RS04085
gene id: 406327:MEVAN_RS04085
uniprot id: A6UQD5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

406327:MEVAN RS02800
gene id: 406327:MEVAN_RS02800
uniprot id: A6UPN5
names: Similarity
messages: Belongs to the UPF0280 family.

406327:MEVAN RS04835
gene id: 406327:MEVAN_RS04835
uniprot id: A6UQT1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

406327:MEVAN RS02810
gene id: 406327:MEVAN_RS02810
uniprot id: A6UPN7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

406327:MEVAN RS08725
gene id: 406327:MEVAN_RS08725
uniprot id: A6USW8
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

406327:MEVAN RS04625
gene id: 406327:MEVAN_RS04625
uniprot id: A6UQP0
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

406327:MEVAN RS04260
gene id: 406327:MEVAN_RS04260
uniprot id: A6UQH0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

406327:MEVAN RS03570
gene id: 406327:MEVAN_RS03570
uniprot id: A6UQ32
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

406327:MEVAN RS04130
gene id: 406327:MEVAN_RS04130
uniprot id: A6UQE4
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

406327:MEVAN RS02215
gene id: 406327:MEVAN_RS02215
uniprot id: A6UPB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

406327:MEVAN RS01180
gene id: 406327:MEVAN_RS01180
uniprot id: A6UNR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

406327:MEVAN RS03525
gene id: 406327:MEVAN_RS03525
uniprot id: A6UQ23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
messages: Monomer.

406327:MEVAN RS07100
gene id: 406327:MEVAN_RS07100
uniprot id: A6URZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm

406327:MEVAN RS03670
gene id: 406327:MEVAN_RS03670
uniprot id: A6UQ53
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

406327:MEVAN RS06070
gene id: 406327:MEVAN_RS06070
uniprot id: A6URF6
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

406327:MEVAN RS02625
gene id: 406327:MEVAN_RS02625
uniprot id: A6UPK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

406327:MEVAN RS03320
gene id: 406327:MEVAN_RS03320
uniprot id: A6UPY1
names: Function
messages: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.

406327:MEVAN RS07460
gene id: 406327:MEVAN_RS07460
uniprot id: A6US69
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

406327:MEVAN RS04105
gene id: 406327:MEVAN_RS04105
uniprot id: A6UQD9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

406327:MEVAN RS02140
gene id: 406327:MEVAN_RS02140
uniprot id: A6UPA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

406327:MEVAN RS00840
gene id: 406327:MEVAN_RS00840
uniprot id: A6UNK1
names: Function
names: Subunit
messages: Homotetramer.
messages: Involved in F420 biosynthesis through the oxidation of lactaldehyde to lactate.

406327:MEVAN RS02295
gene id: 406327:MEVAN_RS02295
uniprot id: A6UPD4
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

406327:MEVAN RS02995
gene id: 406327:MEVAN_RS02995
uniprot id: A6UPS3
names: Similarity
messages: Belongs to the UPF0166 family.

406327:MEVAN RS06360
gene id: 406327:MEVAN_RS06360
uniprot id: A6URK5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

406327:MEVAN RS07990
gene id: 406327:MEVAN_RS07990
uniprot id: A6USH6
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

406327:MEVAN RS01695
gene id: 406327:MEVAN_RS01695
uniprot id: A6UP16
names: Similarity
messages: Belongs to the TrpF family.

406327:MEVAN RS05165
gene id: 406327:MEVAN_RS05165
uniprot id: A6UQZ1
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

406327:MEVAN RS08570
gene id: 406327:MEVAN_RS08570
uniprot id: A6UST7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

406327:MEVAN RS06445
gene id: 406327:MEVAN_RS06445
uniprot id: A6URM1
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS01220
gene id: 406327:MEVAN_RS01220
uniprot id: A6UNS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.

406327:MEVAN RS02610
gene id: 406327:MEVAN_RS02610
uniprot id: A6UPJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

406327:MEVAN RS02150
gene id: 406327:MEVAN_RS02150
uniprot id: A6UPA5
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

406327:MEVAN RS05095
gene id: 406327:MEVAN_RS05095
uniprot id: A6UQX7
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

406327:MEVAN RS05740
gene id: 406327:MEVAN_RS05740
uniprot id: A6UR93
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS06640
gene id: 406327:MEVAN_RS06640
uniprot id: A6URR1
names: Similarity
messages: Belongs to the HypE family.

406327:MEVAN RS06580
gene id: 406327:MEVAN_RS06580
uniprot id: A6URP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

406327:MEVAN RS03970
gene id: 406327:MEVAN_RS03970
uniprot id: A6UQB3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

406327:MEVAN RS03135
gene id: 406327:MEVAN_RS03135
uniprot id: A6UPU7
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS00820
gene id: 406327:MEVAN_RS00820
uniprot id: A6UNJ7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

406327:MEVAN RS03990
gene id: 406327:MEVAN_RS03990
uniprot id: A6UQB6
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

406327:MEVAN RS01895
gene id: 406327:MEVAN_RS01895
uniprot id: A6UP56
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

406327:MEVAN RS03385
gene id: 406327:MEVAN_RS03385
uniprot id: A6UPZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

406327:MEVAN RS03170
gene id: 406327:MEVAN_RS03170
uniprot id: A6UPV4
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

406327:MEVAN RS07250
gene id: 406327:MEVAN_RS07250
uniprot id: A6US28
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

406327:MEVAN RS05125
gene id: 406327:MEVAN_RS05125
uniprot id: A6UQY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

406327:MEVAN RS07885
gene id: 406327:MEVAN_RS07885
uniprot id: A6USF5
names: Similarity
messages: Belongs to the UPF0237 family.

406327:MEVAN RS07095
gene id: 406327:MEVAN_RS07095
uniprot id: A6URZ7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.

406327:MEVAN RS05990
gene id: 406327:MEVAN_RS05990
uniprot id: A6URE0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

406327:MEVAN RS03000
gene id: 406327:MEVAN_RS03000
uniprot id: A6UPS4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

406327:MEVAN RS07075
gene id: 406327:MEVAN_RS07075
uniprot id: A6URZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mj S-layer protein family.
messages: S-layer
messages: S-layer protein. The S-layer is a paracrystalline mono-layered assembly of proteins which coat the surface of the cell.

406327:MEVAN RS03465
gene id: 406327:MEVAN_RS03465
uniprot id: P14026
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

406327:MEVAN RS00945
gene id: 406327:MEVAN_RS00945
uniprot id: A6UNM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.

406327:MEVAN RS04945
gene id: 406327:MEVAN_RS04945
uniprot id: P95316
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

406327:MEVAN RS02055
gene id: 406327:MEVAN_RS02055
uniprot id: A6UP86
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

406327:MEVAN RS07410
gene id: 406327:MEVAN_RS07410
uniprot id: A6US60
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

406327:MEVAN RS04675
gene id: 406327:MEVAN_RS04675
uniprot id: A6UQQ0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

406327:MEVAN RS08065
gene id: 406327:MEVAN_RS08065
uniprot id: A6USJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

406327:MEVAN RS07760
gene id: 406327:MEVAN_RS07760
uniprot id: A6USD0
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

406327:MEVAN RS06740
gene id: 406327:MEVAN_RS06740
uniprot id: A6URT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

406327:MEVAN RS04380
gene id: 406327:MEVAN_RS04380
uniprot id: P10143
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

406327:MEVAN RS06510
gene id: 406327:MEVAN_RS06510
uniprot id: A6URN4
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

406327:MEVAN RS03470
gene id: 406327:MEVAN_RS03470
uniprot id: P14040
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

406327:MEVAN RS01215
gene id: 406327:MEVAN_RS01215
uniprot id: A6UNS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

406327:MEVAN RS07775
gene id: 406327:MEVAN_RS07775
uniprot id: A6USD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

406327:MEVAN RS01755
gene id: 406327:MEVAN_RS01755
uniprot id: A6UP28
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

406327:MEVAN RS02145
gene id: 406327:MEVAN_RS02145
uniprot id: A6UPA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

406327:MEVAN RS03645
gene id: 406327:MEVAN_RS03645
uniprot id: A6UQ48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

406327:MEVAN RS01610
gene id: 406327:MEVAN_RS01610
uniprot id: A6UNZ8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

406327:MEVAN RS06530
gene id: 406327:MEVAN_RS06530
uniprot id: A6URN8
names: Similarity
messages: Belongs to the SDO1/SBDS family.

406327:MEVAN RS07255
gene id: 406327:MEVAN_RS07255
uniprot id: A6US29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

406327:MEVAN RS02895
gene id: 406327:MEVAN_RS02895
uniprot id: A6UPQ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

406327:MEVAN RS00260
gene id: 406327:MEVAN_RS00260
uniprot id: A6UN92
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS03790
gene id: 406327:MEVAN_RS03790
uniprot id: A6UQ77
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

406327:MEVAN RS00645
gene id: 406327:MEVAN_RS00645
uniprot id: A6UNG5
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

406327:MEVAN RS02425
gene id: 406327:MEVAN_RS02425
uniprot id: A6UPG0
names: Function
names: Similarity
messages: Belongs to the HdrB family.
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).

406327:MEVAN RS06780
gene id: 406327:MEVAN_RS06780
uniprot id: A6URT9
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the archaeal N-glycosylase/DNA lyase (AGOG) family.
messages: Contains two alpha-helical subdomains, with the 8-oxoguanine binding site located in a cleft at their interface. Contains a helix-hairpin-helix (HhH) structural motif and a Gly/Pro-rich sequence followed by a conserved Asp (HhH-GPD motif).
messages: DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

406327:MEVAN RS02185
gene id: 406327:MEVAN_RS02185
uniprot id: A6UPB2
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

406327:MEVAN RS05000
gene id: 406327:MEVAN_RS05000
uniprot id: A6UQV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

406327:MEVAN RS03065
gene id: 406327:MEVAN_RS03065
uniprot id: A6UPT4
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

406327:MEVAN RS03700
gene id: 406327:MEVAN_RS03700
uniprot id: A6UQ59
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

406327:MEVAN RS02415
gene id: 406327:MEVAN_RS02415
uniprot id: A6UPF8
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

406327:MEVAN RS06875
gene id: 406327:MEVAN_RS06875
uniprot id: A6URV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

406327:MEVAN RS04190
gene id: 406327:MEVAN_RS04190
uniprot id: A6UQF6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

406327:MEVAN RS06205
gene id: 406327:MEVAN_RS06205
uniprot id: A6URH7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

406327:MEVAN RS05965
gene id: 406327:MEVAN_RS05965
uniprot id: A6URD5
names: Similarity
messages: Belongs to the UPF0288 family.

406327:MEVAN RS03665
gene id: 406327:MEVAN_RS03665
uniprot id: A6UQ52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

406327:MEVAN RS05525
gene id: 406327:MEVAN_RS05525
uniprot id: A6UR60
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

406327:MEVAN RS06575
gene id: 406327:MEVAN_RS06575
uniprot id: P15824
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L1 operon by binding to its mRNA. Thus it also controls transcription of L10 and L12 by translational coupling. Unlike the case in E.coli, where the site is in the untranslated mRNA leader, this site is within the L1 protein's structural gene.

406327:MEVAN RS02890
gene id: 406327:MEVAN_RS02890
uniprot id: A6UPQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

406327:MEVAN RS04240
gene id: 406327:MEVAN_RS04240
uniprot id: A6UQG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

406327:MEVAN RS00375
gene id: 406327:MEVAN_RS00375
uniprot id: A6UNB4
names: Similarity
messages: Belongs to the MvhD/VhuD family.

406327:MEVAN RS02680
gene id: 406327:MEVAN_RS02680
uniprot id: A6UPL1
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

406327:MEVAN RS07520
gene id: 406327:MEVAN_RS07520
uniprot id: A6US81
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

406327:MEVAN RS03680
gene id: 406327:MEVAN_RS03680
uniprot id: A6UQ55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

406327:MEVAN RS02105
gene id: 406327:MEVAN_RS02105
uniprot id: A6UP96
names: Similarity
messages: Belongs to the polysaccharide synthase family.

406327:MEVAN RS03770
gene id: 406327:MEVAN_RS03770
uniprot id: A6UQ73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Membrane

406327:MEVAN RS08775
gene id: 406327:MEVAN_RS08775
uniprot id: A6UNF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRISPR system Cmr5 family.
messages: Cytoplasm

406327:MEVAN RS06525
gene id: 406327:MEVAN_RS06525
uniprot id: A6URN7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.
messages: Binds 1 zinc ion per subunit.

406327:MEVAN RS07155
gene id: 406327:MEVAN_RS07155
uniprot id: A6US09
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

406327:MEVAN RS00590
gene id: 406327:MEVAN_RS00590
uniprot id: A6UNF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

406327:MEVAN RS01865
gene id: 406327:MEVAN_RS01865
uniprot id: A6UP50
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

406327:MEVAN RS03045
gene id: 406327:MEVAN_RS03045
uniprot id: A6UPT0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Binds two Mg(2+) per subunit.
messages: Forms a ternary complex with MCM helicase and DNA.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

406327:MEVAN RS06505
gene id: 406327:MEVAN_RS06505
uniprot id: A6URN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

406327:MEVAN RS07710
gene id: 406327:MEVAN_RS07710
uniprot id: A6USC0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

406327:MEVAN RS04910
gene id: 406327:MEVAN_RS04910
uniprot id: A6UQU0
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

406327:MEVAN RS06690
gene id: 406327:MEVAN_RS06690
uniprot id: A6URS1
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

406327:MEVAN RS04020
gene id: 406327:MEVAN_RS04020
uniprot id: A6UQC2
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

406327:MEVAN RS04525
gene id: 406327:MEVAN_RS04525
uniprot id: A6UQL9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

406327:MEVAN RS05010
gene id: 406327:MEVAN_RS05010
uniprot id: A6UQW0
names: Similarity
messages: Belongs to the UPF0179 family.

406327:MEVAN RS03755
gene id: 406327:MEVAN_RS03755
uniprot id: A6UQ70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

406327:MEVAN RS02905
gene id: 406327:MEVAN_RS02905
uniprot id: A6UPQ6
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

406327:MEVAN RS02395
gene id: 406327:MEVAN_RS02395
uniprot id: A6UPF4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.

406327:MEVAN RS05605
gene id: 406327:MEVAN_RS05605
uniprot id: A6UR74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

406327:MEVAN RS02760
gene id: 406327:MEVAN_RS02760
uniprot id: A6UPM7
names: Similarity
messages: Belongs to the FUN14 family.

406327:MEVAN RS08130
gene id: 406327:MEVAN_RS08130
uniprot id: A6USK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Catalyzes the four-electron oxidation of UDP-N-acetyl-D-mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N-acetylmannosaminuronic acid (UDP-ManNAcA).
messages: Homotetramer; probably dimer of dimers.

406327:MEVAN RS02560
gene id: 406327:MEVAN_RS02560
uniprot id: A6UPI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Membrane

406327:MEVAN RS03340
gene id: 406327:MEVAN_RS03340
uniprot id: A6UPY5
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

406327:MEVAN RS04175
gene id: 406327:MEVAN_RS04175
uniprot id: A6UQF3
names: Similarity
messages: Belongs to the UPF0212 family.

406327:MEVAN RS01505
gene id: 406327:MEVAN_RS01505
uniprot id: A6UNX7
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

406327:MEVAN RS04610
gene id: 406327:MEVAN_RS04610
uniprot id: A6UQN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

406327:MEVAN RS03490
gene id: 406327:MEVAN_RS03490
uniprot id: P14039
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

406327:MEVAN RS07290
gene id: 406327:MEVAN_RS07290
uniprot id: A6US36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

406327:MEVAN RS04315
gene id: 406327:MEVAN_RS04315
uniprot id: A6UQI1
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

406327:MEVAN RS05305
gene id: 406327:MEVAN_RS05305
uniprot id: A6UR16
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

406327:MEVAN RS08665
gene id: 406327:MEVAN_RS08665
uniprot id: A6USV6
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS02120
gene id: 406327:MEVAN_RS02120
uniprot id: A6UP99
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

406327:MEVAN RS05310
gene id: 406327:MEVAN_RS05310
uniprot id: A6UR17
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

406327:MEVAN RS02325
gene id: 406327:MEVAN_RS02325
uniprot id: A6UPE0
names: Similarity
messages: Belongs to the LDH2/MDH2 oxidoreductase family.

406327:MEVAN RS01500
gene id: 406327:MEVAN_RS01500
uniprot id: A6UNX6
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

406327:MEVAN RS02650
gene id: 406327:MEVAN_RS02650
uniprot id: A6UPK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

406327:MEVAN RS07645
gene id: 406327:MEVAN_RS07645
uniprot id: A6USA6
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

406327:MEVAN RS03685
gene id: 406327:MEVAN_RS03685
uniprot id: A6UQ56
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

406327:MEVAN RS03585
gene id: 406327:MEVAN_RS03585
uniprot id: A6UQ36
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

406327:MEVAN RS01850
gene id: 406327:MEVAN_RS01850
uniprot id: A6UP47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

406327:MEVAN RS03125
gene id: 406327:MEVAN_RS03125
uniprot id: A6UPU5
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS03230
gene id: 406327:MEVAN_RS03230
uniprot id: A6UPW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

406327:MEVAN RS03975
gene id: 406327:MEVAN_RS03975
uniprot id: A6UQB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

406327:MEVAN RS08340
gene id: 406327:MEVAN_RS08340
uniprot id: A6USP3
names: Similarity
messages: Belongs to the FldB/FldC dehydratase alpha/beta subunit family.

406327:MEVAN RS01260
gene id: 406327:MEVAN_RS01260
uniprot id: A6UNT3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

406327:MEVAN RS02400
gene id: 406327:MEVAN_RS02400
uniprot id: A6UPF5
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

406327:MEVAN RS04465
gene id: 406327:MEVAN_RS04465
uniprot id: A6UQK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

406327:MEVAN RS01280
gene id: 406327:MEVAN_RS01280
uniprot id: A6UNT7
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

406327:MEVAN RS07305
gene id: 406327:MEVAN_RS07305
uniprot id: A6US39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

406327:MEVAN RS06460
gene id: 406327:MEVAN_RS06460
uniprot id: A6URM4
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS00280
gene id: 406327:MEVAN_RS00280
uniprot id: A6UN95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

406327:MEVAN RS04760
gene id: 406327:MEVAN_RS04760
uniprot id: A6UQR7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

406327:MEVAN RS01940
gene id: 406327:MEVAN_RS01940
uniprot id: A6UP65
names: Similarity
messages: Belongs to the UPF0235 family.

406327:MEVAN RS03725
gene id: 406327:MEVAN_RS03725
uniprot id: A6UQ64
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

406327:MEVAN RS03760
gene id: 406327:MEVAN_RS03760
uniprot id: A6UQ71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

406327:MEVAN RS02160
gene id: 406327:MEVAN_RS02160
uniprot id: A6UPA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Membrane

406327:MEVAN RS02095
gene id: 406327:MEVAN_RS02095
uniprot id: A6UP94
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

406327:MEVAN RS05440
gene id: 406327:MEVAN_RS05440
uniprot id: A6UR43
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

406327:MEVAN RS00350
gene id: 406327:MEVAN_RS00350
uniprot id: A6UNA9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

406327:MEVAN RS07365
gene id: 406327:MEVAN_RS07365
uniprot id: A6US51
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

406327:MEVAN RS06520
gene id: 406327:MEVAN_RS06520
uniprot id: A6URN6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

406327:MEVAN RS07495
gene id: 406327:MEVAN_RS07495
uniprot id: A6US76
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

406327:MEVAN RS04645
gene id: 406327:MEVAN_RS04645
uniprot id: A6UQP4
names: Function
messages: Part of a potassium transport system.

406327:MEVAN RS05405
gene id: 406327:MEVAN_RS05405
uniprot id: A6UR36
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

406327:MEVAN RS03215
gene id: 406327:MEVAN_RS03215
uniprot id: A6UPW3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

406327:MEVAN RS05015
gene id: 406327:MEVAN_RS05015
uniprot id: A6UQW1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

406327:MEVAN RS05515
gene id: 406327:MEVAN_RS05515
uniprot id: A6UR58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

406327:MEVAN RS06595
gene id: 406327:MEVAN_RS06595
uniprot id: A6URQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

406327:MEVAN RS04590
gene id: 406327:MEVAN_RS04590
uniprot id: A6UQN3
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

406327:MEVAN RS05345
gene id: 406327:MEVAN_RS05345
uniprot id: A6UR19
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

406327:MEVAN RS03240
gene id: 406327:MEVAN_RS03240
uniprot id: A6UPW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

406327:MEVAN RS02125
gene id: 406327:MEVAN_RS02125
uniprot id: A6UPA0
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS02585
gene id: 406327:MEVAN_RS02585
uniprot id: A6UPJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

406327:MEVAN RS04080
gene id: 406327:MEVAN_RS04080
uniprot id: A6UQD4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

406327:MEVAN RS00390
gene id: 406327:MEVAN_RS00390
uniprot id: A6UNB7
names: Similarity
messages: Belongs to the FrhG family.

406327:MEVAN RS05590
gene id: 406327:MEVAN_RS05590
uniprot id: A6UR71
names: Similarity
messages: Belongs to the glutamate synthase family.

406327:MEVAN RS07570
gene id: 406327:MEVAN_RS07570
uniprot id: P35552
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

406327:MEVAN RS06555
gene id: 406327:MEVAN_RS06555
uniprot id: A6URP4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

406327:MEVAN RS07630
gene id: 406327:MEVAN_RS07630
uniprot id: A6USA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

406327:MEVAN RS01690
gene id: 406327:MEVAN_RS01690
uniprot id: A6UP15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

406327:MEVAN RS06275
gene id: 406327:MEVAN_RS06275
uniprot id: A6URJ1
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

406327:MEVAN RS01510
gene id: 406327:MEVAN_RS01510
uniprot id: A6UNX8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

406327:MEVAN RS06125
gene id: 406327:MEVAN_RS06125
uniprot id: A6URG6
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

406327:MEVAN RS05875
gene id: 406327:MEVAN_RS05875
uniprot id: A6URC0
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

406327:MEVAN RS01245
gene id: 406327:MEVAN_RS01245
uniprot id: A6UNT0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

406327:MEVAN RS05080
gene id: 406327:MEVAN_RS05080
uniprot id: A6UQX3
names: Similarity
messages: Belongs to the HisA/HisF family.

406327:MEVAN RS01935
gene id: 406327:MEVAN_RS01935
uniprot id: A6UP64
names: Similarity
messages: Belongs to the HdrC family.

406327:MEVAN RS00110
gene id: 406327:MEVAN_RS00110
uniprot id: A6UN62
names: Similarity
messages: Belongs to the UPF0107 family.

406327:MEVAN RS04370
gene id: 406327:MEVAN_RS04370
uniprot id: A6UQJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

406327:MEVAN RS04205
gene id: 406327:MEVAN_RS04205
uniprot id: A6UQF9
names: Similarity
messages: Belongs to the AlaDH/PNT family.

406327:MEVAN RS04125
gene id: 406327:MEVAN_RS04125
uniprot id: A6UQE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

406327:MEVAN RS01605
gene id: 406327:MEVAN_RS01605
uniprot id: A6UNZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhB family.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation.

406327:MEVAN RS05495
gene id: 406327:MEVAN_RS05495
uniprot id: A6UR54
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

406327:MEVAN RS07355
gene id: 406327:MEVAN_RS07355
uniprot id: A6US49
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

406327:MEVAN RS05750
gene id: 406327:MEVAN_RS05750
uniprot id: A6UR95
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

406327:MEVAN RS00335
gene id: 406327:MEVAN_RS00335
uniprot id: A6UNA6
names: Similarity
messages: Belongs to the P(II) protein family.

406327:MEVAN RS06495
gene id: 406327:MEVAN_RS06495
uniprot id: A6URN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

406327:MEVAN RS05185
gene id: 406327:MEVAN_RS05185
uniprot id: A6UQZ5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

406327:MEVAN RS07930
gene id: 406327:MEVAN_RS07930
uniprot id: A6USG4
names: Similarity
messages: Belongs to the NodU/CmcH family.

406327:MEVAN RS04455
gene id: 406327:MEVAN_RS04455
uniprot id: A6UQK5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Cytoplasm
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

406327:MEVAN RS05690
gene id: 406327:MEVAN_RS05690
uniprot id: A6UR91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

406327:MEVAN RS06925
gene id: 406327:MEVAN_RS06925
uniprot id: A6URW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

406327:MEVAN RS04865
gene id: 406327:MEVAN_RS04865
uniprot id: A6UQT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

406327:MEVAN RS06235
gene id: 406327:MEVAN_RS06235
uniprot id: A6URI3
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

406327:MEVAN RS04575
gene id: 406327:MEVAN_RS04575
uniprot id: A6UQN0
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

406327:MEVAN RS04490
gene id: 406327:MEVAN_RS04490
uniprot id: A6UQL2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrG family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

406327:MEVAN RS05625
gene id: 406327:MEVAN_RS05625
uniprot id: A6UR78
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

406327:MEVAN RS00890
gene id: 406327:MEVAN_RS00890
uniprot id: A6UNL0
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

406327:MEVAN RS02030
gene id: 406327:MEVAN_RS02030
uniprot id: A6UP81
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

406327:MEVAN RS05580
gene id: 406327:MEVAN_RS05580
uniprot id: A6UR69
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

406327:MEVAN RS04410
gene id: 406327:MEVAN_RS04410
uniprot id: A6UQJ8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

406327:MEVAN RS01765
gene id: 406327:MEVAN_RS01765
uniprot id: A6UP30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
messages: Chromosome
messages: Cytoplasm

406327:MEVAN RS05500
gene id: 406327:MEVAN_RS05500
uniprot id: A6UR55
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

406327:MEVAN RS06260
gene id: 406327:MEVAN_RS06260
uniprot id: A6URI8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

406327:MEVAN RS04220
gene id: 406327:MEVAN_RS04220
uniprot id: A6UQG2
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

406327:MEVAN RS05950
gene id: 406327:MEVAN_RS05950
uniprot id: A6URD2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

406327:MEVAN RS00135
gene id: 406327:MEVAN_RS00135
uniprot id: A6UN67
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS04050
gene id: 406327:MEVAN_RS04050
uniprot id: A6UQC8
names: Similarity
messages: Belongs to the MoaB/Mog family.

406327:MEVAN RS00340
gene id: 406327:MEVAN_RS00340
uniprot id: A6UNA7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.
messages: The reversible ADP-ribosylation of Arg-100 inactivates the nitrogenase reductase and regulates nitrogenase activity.

406327:MEVAN RS07720
gene id: 406327:MEVAN_RS07720
uniprot id: A6USC2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

406327:MEVAN RS02420
gene id: 406327:MEVAN_RS02420
uniprot id: A6UPF9
names: Similarity
messages: Belongs to the HdrC family.

406327:MEVAN RS04470
gene id: 406327:MEVAN_RS04470
uniprot id: A6UQK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

406327:MEVAN RS05320
gene id: 406327:MEVAN_RS05320
uniprot id: A6UR19
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

406327:MEVAN RS04570
gene id: 406327:MEVAN_RS04570
uniprot id: A6UQM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

406327:MEVAN RS00485
gene id: 406327:MEVAN_RS00485
uniprot id: A6UND5
names: Similarity
messages: Belongs to the heat shock protein 70 family.

406327:MEVAN RS06610
gene id: 406327:MEVAN_RS06610
uniprot id: A6URQ5
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

406327:MEVAN RS07395
gene id: 406327:MEVAN_RS07395
uniprot id: A6US57
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

406327:MEVAN RS02730
gene id: 406327:MEVAN_RS02730
uniprot id: A6UPM1
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.

406327:MEVAN RS08335
gene id: 406327:MEVAN_RS08335
uniprot id: A6USP2
names: Similarity
messages: Belongs to the RNase H family.

406327:MEVAN RS01295
gene id: 406327:MEVAN_RS01295
uniprot id: A6UNU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

406327:MEVAN RS07475
gene id: 406327:MEVAN_RS07475
uniprot id: A6US72
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

406327:MEVAN RS07225
gene id: 406327:MEVAN_RS07225
uniprot id: A6US23
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

406327:MEVAN RS05115
gene id: 406327:MEVAN_RS05115
uniprot id: A6UQY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

406327:MEVAN RS02315
gene id: 406327:MEVAN_RS02315
uniprot id: A6UPD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

406327:MEVAN RS04280
gene id: 406327:MEVAN_RS04280
uniprot id: A6UQH4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

406327:MEVAN RS04015
gene id: 406327:MEVAN_RS04015
uniprot id: A6UQC1
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

406327:MEVAN RS05370
gene id: 406327:MEVAN_RS05370
uniprot id: A6UR19
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

406327:MEVAN RS07245
gene id: 406327:MEVAN_RS07245
uniprot id: A6US27
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.
messages: The N-terminal domain is an archaea-specific tRNA-editing domain that hydrolyzes incorrectly charged L-seryl-tRNA(Thr). Catalysis of tRNA editing is performed by the charged tRNA itself.

406327:MEVAN RS01970
gene id: 406327:MEVAN_RS01970
uniprot id: A6UP69
names: Similarity
messages: Belongs to the IMPACT family.

406327:MEVAN RS02510
gene id: 406327:MEVAN_RS02510
uniprot id: A6UPH7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

406327:MEVAN RS07200
gene id: 406327:MEVAN_RS07200
uniprot id: A6US18
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

406327:MEVAN RS02290
gene id: 406327:MEVAN_RS02290
uniprot id: A6UPD3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

406327:MEVAN RS06700
gene id: 406327:MEVAN_RS06700
uniprot id: A6URS3
names: Similarity
messages: Belongs to the UPF0248 family.

406327:MEVAN RS04925
gene id: 406327:MEVAN_RS04925
uniprot id: A6UQU3
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

406327:MEVAN RS07935
gene id: 406327:MEVAN_RS07935
uniprot id: A6USG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

406327:MEVAN RS01870
gene id: 406327:MEVAN_RS01870
uniprot id: A6UP51
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

406327:MEVAN RS02655
gene id: 406327:MEVAN_RS02655
uniprot id: A6UPK6
names: Similarity
messages: Belongs to the glutamine synthetase family.

406327:MEVAN RS07910
gene id: 406327:MEVAN_RS07910
uniprot id: A6USG1
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS04305
gene id: 406327:MEVAN_RS04305
uniprot id: A6UQH9
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

406327:MEVAN RS06845
gene id: 406327:MEVAN_RS06845
uniprot id: A6URV2
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

406327:MEVAN RS07635
gene id: 406327:MEVAN_RS07635
uniprot id: A6USA4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

406327:MEVAN RS00165
gene id: 406327:MEVAN_RS00165
uniprot id: A6UN73
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

406327:MEVAN RS03800
gene id: 406327:MEVAN_RS03800
uniprot id: A6UQ79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

406327:MEVAN RS06850
gene id: 406327:MEVAN_RS06850
uniprot id: A6URV3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

406327:MEVAN RS05870
gene id: 406327:MEVAN_RS05870
uniprot id: A6URB9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

406327:MEVAN RS01050
gene id: 406327:MEVAN_RS01050
uniprot id: A6UNP1
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Homotetramer; probably dimer of dimers.

406327:MEVAN RS02505
gene id: 406327:MEVAN_RS02505
uniprot id: A6UPH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

406327:MEVAN RS01630
gene id: 406327:MEVAN_RS01630
uniprot id: A6UP02
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

406327:MEVAN RS05575
gene id: 406327:MEVAN_RS05575
uniprot id: A6UR68
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

406327:MEVAN RS07195
gene id: 406327:MEVAN_RS07195
uniprot id: A6US17
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.

406327:MEVAN RS05170
gene id: 406327:MEVAN_RS05170
uniprot id: A6UQZ2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

406327:MEVAN RS07160
gene id: 406327:MEVAN_RS07160
uniprot id: A6US10
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

406327:MEVAN RS01890
gene id: 406327:MEVAN_RS01890
uniprot id: A6UP55
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

406327:MEVAN RS07830
gene id: 406327:MEVAN_RS07830
uniprot id: A6USE4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

406327:MEVAN RS08140
gene id: 406327:MEVAN_RS08140
uniprot id: A6USK6
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

406327:MEVAN RS03235
gene id: 406327:MEVAN_RS03235
uniprot id: A6UPW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

406327:MEVAN RS07925
gene id: 406327:MEVAN_RS07925
uniprot id: A6USG3
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

406327:MEVAN RS01920
gene id: 406327:MEVAN_RS01920
uniprot id: A6UP61
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

406327:MEVAN RS07665
gene id: 406327:MEVAN_RS07665
uniprot id: A6USB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

406327:MEVAN RS05285
gene id: 406327:MEVAN_RS05285
uniprot id: A6UR12
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

406327:MEVAN RS03315
gene id: 406327:MEVAN_RS03315
uniprot id: A6UPY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

406327:MEVAN RS03600
gene id: 406327:MEVAN_RS03600
uniprot id: A6UQ39
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.

406327:MEVAN RS00765
gene id: 406327:MEVAN_RS00765
uniprot id: A6UNI6
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS05505
gene id: 406327:MEVAN_RS05505
uniprot id: A6UR56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

406327:MEVAN RS05150
gene id: 406327:MEVAN_RS05150
uniprot id: A6UQY8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the creatininase superfamily. FAPy deformylase family.
messages: Catalyzes the hydrolysis of the formamide of 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-monophosphate (FAPy) to form 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (APy).
messages: Homodimer.
messages: Requires an additional second metal ion that could be Fe(2+) or Zn(2+).
messages: Requires one Fe(2+) ion for activity.

406327:MEVAN RS01175
gene id: 406327:MEVAN_RS01175
uniprot id: A6UNR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

406327:MEVAN RS00290
gene id: 406327:MEVAN_RS00290
uniprot id: A6UN97
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

406327:MEVAN RS06860
gene id: 406327:MEVAN_RS06860
uniprot id: A6URV5
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

406327:MEVAN RS03475
gene id: 406327:MEVAN_RS03475
uniprot id: P14037
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: It is uncertain whether Met-1 or Leu-7 is the initiator.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

406327:MEVAN RS00935
gene id: 406327:MEVAN_RS00935
uniprot id: A6UNL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

406327:MEVAN RS06545
gene id: 406327:MEVAN_RS06545
uniprot id: A6URP2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

406327:MEVAN RS01460
gene id: 406327:MEVAN_RS01460
uniprot id: A6UNW8
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS04520
gene id: 406327:MEVAN_RS04520
uniprot id: A6UQL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.

406327:MEVAN RS02350
gene id: 406327:MEVAN_RS02350
uniprot id: A6UPE5
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

406327:MEVAN RS04165
gene id: 406327:MEVAN_RS04165
uniprot id: A6UQF1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

406327:MEVAN RS02830
gene id: 406327:MEVAN_RS02830
uniprot id: A6UPP1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

406327:MEVAN RS07135
gene id: 406327:MEVAN_RS07135
uniprot id: A6US05
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

406327:MEVAN RS04235
gene id: 406327:MEVAN_RS04235
uniprot id: A6UQG5
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS07715
gene id: 406327:MEVAN_RS07715
uniprot id: A6USC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

406327:MEVAN RS04535
gene id: 406327:MEVAN_RS04535
uniprot id: A6UQM2
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

406327:MEVAN RS00090
gene id: 406327:MEVAN_RS00090
uniprot id: A6UN58
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

406327:MEVAN RS06770
gene id: 406327:MEVAN_RS06770
uniprot id: A6URT7
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

406327:MEVAN RS03785
gene id: 406327:MEVAN_RS03785
uniprot id: A6UQ76
names: Function
names: Similarity
messages: Belongs to the 2-phosphoglycerate kinase family.
messages: Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant.

406327:MEVAN RS02310
gene id: 406327:MEVAN_RS02310
uniprot id: A6UPD7
names: Similarity
messages: Belongs to the UPF0047 family.

406327:MEVAN RS05415
gene id: 406327:MEVAN_RS05415
uniprot id: A6UR38
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

406327:MEVAN RS07980
gene id: 406327:MEVAN_RS07980
uniprot id: A6USH4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

406327:MEVAN RS08255
gene id: 406327:MEVAN_RS08255
uniprot id: A6USM7
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

406327:MEVAN RS00670
gene id: 406327:MEVAN_RS00670
uniprot id: A6UNG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

406327:MEVAN RS03620
gene id: 406327:MEVAN_RS03620
uniprot id: A6UQ43
names: Similarity
messages: Belongs to the peptidase M20A family.

406327:MEVAN RS06330
gene id: 406327:MEVAN_RS06330
uniprot id: A6URJ9
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

406327:MEVAN RS01800
gene id: 406327:MEVAN_RS01800
uniprot id: A6UP37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

406327:MEVAN RS04530
gene id: 406327:MEVAN_RS04530
uniprot id: A6UQM0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BioW family.
messages: Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.
messages: Homodimer.

406327:MEVAN RS04155
gene id: 406327:MEVAN_RS04155
uniprot id: A6UQE9
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

406327:MEVAN RS07140
gene id: 406327:MEVAN_RS07140
uniprot id: A6US06
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

406327:MEVAN RS04035
gene id: 406327:MEVAN_RS04035
uniprot id: A6UQC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

406327:MEVAN RS06265
gene id: 406327:MEVAN_RS06265
uniprot id: A6URI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

406327:MEVAN RS04025
gene id: 406327:MEVAN_RS04025
uniprot id: A6UQC3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

406327:MEVAN RS05360
gene id: 406327:MEVAN_RS05360
uniprot id: A6UR17
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

406327:MEVAN RS06410
gene id: 406327:MEVAN_RS06410
uniprot id: A6URL4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

406327:MEVAN RS08055
gene id: 406327:MEVAN_RS08055
uniprot id: A6USI9
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS04545
gene id: 406327:MEVAN_RS04545
uniprot id: A6UQM4
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

406327:MEVAN RS07615
gene id: 406327:MEVAN_RS07615
uniprot id: A6USA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

406327:MEVAN RS05975
gene id: 406327:MEVAN_RS05975
uniprot id: A6URD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

406327:MEVAN RS07400
gene id: 406327:MEVAN_RS07400
uniprot id: A6US58
names: Similarity
messages: Belongs to the UPF0146 family.

406327:MEVAN RS08375
gene id: 406327:MEVAN_RS08375
uniprot id: A6USP9
names: Similarity
messages: Belongs to the DEAD box helicase family.

406327:MEVAN RS07590
gene id: 406327:MEVAN_RS07590
uniprot id: A6US95
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS07025
gene id: 406327:MEVAN_RS07025
uniprot id: A6URY5
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

406327:MEVAN RS05955
gene id: 406327:MEVAN_RS05955
uniprot id: A6URD3
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS07130
gene id: 406327:MEVAN_RS07130
uniprot id: A6US04
names: Cofactor
names: Similarity
messages: Belongs to the GARS family.
messages: Binds 2 magnesium or manganese ions per subunit.

406327:MEVAN RS02255
gene id: 406327:MEVAN_RS02255
uniprot id: A6UPC6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

406327:MEVAN RS01780
gene id: 406327:MEVAN_RS01780
uniprot id: A6UP33
names: Similarity
messages: Belongs to the aspartokinase family.

406327:MEVAN RS00225
gene id: 406327:MEVAN_RS00225
uniprot id: A6UN85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

406327:MEVAN RS03650
gene id: 406327:MEVAN_RS03650
uniprot id: A6UQ49
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

406327:MEVAN RS03775
gene id: 406327:MEVAN_RS03775
uniprot id: A6UQ74
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

406327:MEVAN RS01705
gene id: 406327:MEVAN_RS01705
uniprot id: A6UP18
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

406327:MEVAN RS00325
gene id: 406327:MEVAN_RS00325
uniprot id: A6UNA4
names: Function
names: Subunit
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

406327:MEVAN RS07505
gene id: 406327:MEVAN_RS07505
uniprot id: A6US78
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

406327:MEVAN RS01520
gene id: 406327:MEVAN_RS01520
uniprot id: A6UNY0
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

406327:MEVAN RS06730
gene id: 406327:MEVAN_RS06730
uniprot id: A6URS9
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

406327:MEVAN RS05920
gene id: 406327:MEVAN_RS05920
uniprot id: A6URC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

406327:MEVAN RS06285
gene id: 406327:MEVAN_RS06285
uniprot id: A6URJ3
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

406327:MEVAN RS04565
gene id: 406327:MEVAN_RS04565
uniprot id: A6UQM8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

406327:MEVAN RS07260
gene id: 406327:MEVAN_RS07260
uniprot id: A6US30
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

406327:MEVAN RS07120
gene id: 406327:MEVAN_RS07120
uniprot id: A6US02
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YjjX NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

406327:MEVAN RS00105
gene id: 406327:MEVAN_RS00105
uniprot id: A6UN61
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS04950
gene id: 406327:MEVAN_RS04950
uniprot id: P95317
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

406327:MEVAN RS00185
gene id: 406327:MEVAN_RS00185
uniprot id: A6UN77
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS08215
gene id: 406327:MEVAN_RS08215
uniprot id: A6USL9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

406327:MEVAN RS03550
gene id: 406327:MEVAN_RS03550
uniprot id: A6UQ28
names: Similarity
messages: Belongs to the FrhG family.

406327:MEVAN RS08030
gene id: 406327:MEVAN_RS08030
uniprot id: A6USI4
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS01845
gene id: 406327:MEVAN_RS01845
uniprot id: A6UP46
names: Similarity
messages: Belongs to the band 7/mec-2 family.

406327:MEVAN RS03830
gene id: 406327:MEVAN_RS03830
uniprot id: A6UQ85
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

406327:MEVAN RS08590
gene id: 406327:MEVAN_RS08590
uniprot id: A6USU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

406327:MEVAN RS08160
gene id: 406327:MEVAN_RS08160
uniprot id: A6USK8
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

406327:MEVAN RS04065
gene id: 406327:MEVAN_RS04065
uniprot id: A6UQD1
names: Similarity
messages: Belongs to the peptidase U62 family.

406327:MEVAN RS05615
gene id: 406327:MEVAN_RS05615
uniprot id: A6UR76
names: Function
names: Similarity
messages: Belongs to the Tfx family.
messages: Putative transcriptional regulator.

406327:MEVAN RS01905
gene id: 406327:MEVAN_RS01905
uniprot id: A6UP58
names: Similarity
messages: Belongs to the UPF0216 family.

406327:MEVAN RS00895
gene id: 406327:MEVAN_RS00895
uniprot id: A6UNL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

406327:MEVAN RS06895
gene id: 406327:MEVAN_RS06895
uniprot id: A6URW2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

406327:MEVAN RS06635
gene id: 406327:MEVAN_RS06635
uniprot id: A6URR0
names: Similarity
messages: Belongs to the phosphosulfolactate synthase family.

406327:MEVAN RS05335
gene id: 406327:MEVAN_RS05335
uniprot id: A6UR17
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

406327:MEVAN RS03250
gene id: 406327:MEVAN_RS03250
uniprot id: A6UPW8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

406327:MEVAN RS07900
gene id: 406327:MEVAN_RS07900
uniprot id: A6USF9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.

406327:MEVAN RS02770
gene id: 406327:MEVAN_RS02770
uniprot id: A6UPM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

406327:MEVAN RS06660
gene id: 406327:MEVAN_RS06660
uniprot id: A6URR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

406327:MEVAN RS02465
gene id: 406327:MEVAN_RS02465
uniprot id: A6UPG8
names: Similarity
messages: Belongs to the CutA family.

406327:MEVAN RS02665
gene id: 406327:MEVAN_RS02665
uniprot id: A6UPK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

406327:MEVAN RS02390
gene id: 406327:MEVAN_RS02390
uniprot id: A6UPF3
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

406327:MEVAN RS01140
gene id: 406327:MEVAN_RS01140
uniprot id: A6UNQ9
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

406327:MEVAN RS05480
gene id: 406327:MEVAN_RS05480
uniprot id: A6UR51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

406327:MEVAN RS04415
gene id: 406327:MEVAN_RS04415
uniprot id: A6UQJ9
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

406327:MEVAN RS06775
gene id: 406327:MEVAN_RS06775
uniprot id: A6URT8
names: Function
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

406327:MEVAN RS01820
gene id: 406327:MEVAN_RS01820
uniprot id: A6UP41
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm
messages: Monomer.

406327:MEVAN RS01740
gene id: 406327:MEVAN_RS01740
uniprot id: A6UP25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

406327:MEVAN RS02945
gene id: 406327:MEVAN_RS02945
uniprot id: A6UPR4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

406327:MEVAN RS01815
gene id: 406327:MEVAN_RS01815
uniprot id: A6UP40
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS05840
gene id: 406327:MEVAN_RS05840
uniprot id: A6URB3
names: Similarity
messages: Belongs to the class-I fumarase family.

406327:MEVAN RS01170
gene id: 406327:MEVAN_RS01170
uniprot id: A6UNR4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

406327:MEVAN RS08615
gene id: 406327:MEVAN_RS08615
uniprot id: A6USU6
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS00235
gene id: 406327:MEVAN_RS00235
uniprot id: A6UN87
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: Consists of two subunits, CofG and CofH.

406327:MEVAN RS01770
gene id: 406327:MEVAN_RS01770
uniprot id: A6UP31
names: Similarity
names: Subunit
messages: Belongs to the diaminopimelate dehydrogenase family.
messages: Homodimer.

406327:MEVAN RS00025
gene id: 406327:MEVAN_RS00025
uniprot id: A6UN45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

406327:MEVAN RS02725
gene id: 406327:MEVAN_RS02725
uniprot id: A6UPM0
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

406327:MEVAN RS03710
gene id: 406327:MEVAN_RS03710
uniprot id: A6UQ61
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

406327:MEVAN RS02200
gene id: 406327:MEVAN_RS02200
uniprot id: A6UPB5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

406327:MEVAN RS08075
gene id: 406327:MEVAN_RS08075
uniprot id: A6USJ3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

406327:MEVAN RS08060
gene id: 406327:MEVAN_RS08060
uniprot id: A6USJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

406327:MEVAN RS03655
gene id: 406327:MEVAN_RS03655
uniprot id: A6UQ50
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

406327:MEVAN RS05945
gene id: 406327:MEVAN_RS05945
uniprot id: A6URD1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

406327:MEVAN RS05905
gene id: 406327:MEVAN_RS05905
uniprot id: A6URC4
names: Similarity
messages: Belongs to the TPP enzyme family.

406327:MEVAN RS07870
gene id: 406327:MEVAN_RS07870
uniprot id: A6USF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

406327:MEVAN RS01620
gene id: 406327:MEVAN_RS01620
uniprot id: A6UP00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

406327:MEVAN RS04390
gene id: 406327:MEVAN_RS04390
uniprot id: A6UQJ4
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

406327:MEVAN RS04040
gene id: 406327:MEVAN_RS04040
uniprot id: A6UQC6
names: Subcellular Location Annotation
messages: Membrane

406327:MEVAN RS04735
gene id: 406327:MEVAN_RS04735
uniprot id: A6UQR2
names: Subcellular Location Annotation
messages: Membrane