399550:SMAR RS01670
gene id: 399550:SMAR_RS01670
uniprot id: A3DLD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

399550:SMAR RS06940
gene id: 399550:SMAR_RS06940
uniprot id: A3DP65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

399550:SMAR RS04060
gene id: 399550:SMAR_RS04060
uniprot id: A3DMN2
names: Caution
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

399550:SMAR RS07465
gene id: 399550:SMAR_RS07465
uniprot id: A3DPG7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

399550:SMAR RS06700
gene id: 399550:SMAR_RS06700
uniprot id: A3DP17
names: Similarity
messages: Belongs to the phosphohexose mutase family.

399550:SMAR RS03125
gene id: 399550:SMAR_RS03125
uniprot id: A3DM61
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS06025
gene id: 399550:SMAR_RS06025
uniprot id: A3DNN9
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.

399550:SMAR RS04435
gene id: 399550:SMAR_RS04435
uniprot id: A3DMV1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

399550:SMAR RS00535
gene id: 399550:SMAR_RS00535
uniprot id: A3DKR0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

399550:SMAR RS01560
gene id: 399550:SMAR_RS01560
uniprot id: A3DLB3
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated Csm5 family.
messages: This subunit might be involved in maturation of a crRNA intermediate to its mature form.

399550:SMAR RS01840
gene id: 399550:SMAR_RS01840
uniprot id: A3DLG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

399550:SMAR RS03995
gene id: 399550:SMAR_RS03995
uniprot id: A3DML9
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

399550:SMAR RS04785
gene id: 399550:SMAR_RS04785
uniprot id: A3DN14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

399550:SMAR RS07100
gene id: 399550:SMAR_RS07100
uniprot id: A3DP96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

399550:SMAR RS00875
gene id: 399550:SMAR_RS00875
uniprot id: A3DKX7
names: Similarity
messages: Belongs to the UPRTase family.

399550:SMAR RS06640
gene id: 399550:SMAR_RS06640
uniprot id: A3DP05
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

399550:SMAR RS01140
gene id: 399550:SMAR_RS01140
uniprot id: A3DL30
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.

399550:SMAR RS05070
gene id: 399550:SMAR_RS05070
uniprot id: A3DN67
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.
messages: The N-terminal domain is an archaea-specific tRNA-editing domain that hydrolyzes incorrectly charged L-seryl-tRNA(Thr). Catalysis of tRNA editing is performed by the charged tRNA itself.

399550:SMAR RS03215
gene id: 399550:SMAR_RS03215
uniprot id: A3DM76
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

399550:SMAR RS05685
gene id: 399550:SMAR_RS05685
uniprot id: A3DNI3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

399550:SMAR RS00070
gene id: 399550:SMAR_RS00070
uniprot id: A3DKG8
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

399550:SMAR RS08255
gene id: 399550:SMAR_RS08255
uniprot id: A3DPW5
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

399550:SMAR RS04585
gene id: 399550:SMAR_RS04585
uniprot id: A3DMX8
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

399550:SMAR RS04590
gene id: 399550:SMAR_RS04590
uniprot id: A3DMX9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Binds two Mg(2+) per subunit.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome.

399550:SMAR RS04135
gene id: 399550:SMAR_RS04135
uniprot id: A3DMP4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

399550:SMAR RS04730
gene id: 399550:SMAR_RS04730
uniprot id: A3DN03
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

399550:SMAR RS00750
gene id: 399550:SMAR_RS00750
uniprot id: A3DKV2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

399550:SMAR RS01285
gene id: 399550:SMAR_RS01285
uniprot id: A3DL59
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

399550:SMAR RS06820
gene id: 399550:SMAR_RS06820
uniprot id: A3DP41
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

399550:SMAR RS03255
gene id: 399550:SMAR_RS03255
uniprot id: A3DM83
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

399550:SMAR RS03545
gene id: 399550:SMAR_RS03545
uniprot id: A3DMD5
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

399550:SMAR RS08205
gene id: 399550:SMAR_RS08205
uniprot id: A3DPV6
names: Similarity
messages: Belongs to the AOR/FOR family.

399550:SMAR RS06125
gene id: 399550:SMAR_RS06125
uniprot id: A3DNQ9
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

399550:SMAR RS00815
gene id: 399550:SMAR_RS00815
uniprot id: A3DKW5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

399550:SMAR RS01515
gene id: 399550:SMAR_RS01515
uniprot id: A3DLA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

399550:SMAR RS01440
gene id: 399550:SMAR_RS01440
uniprot id: A3DL90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

399550:SMAR RS05195
gene id: 399550:SMAR_RS05195
uniprot id: A3DN90
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

399550:SMAR RS01385
gene id: 399550:SMAR_RS01385
uniprot id: A3DL79
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

399550:SMAR RS00250
gene id: 399550:SMAR_RS00250
uniprot id: A3DKK4
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS03345
gene id: 399550:SMAR_RS03345
uniprot id: A3DMA1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

399550:SMAR RS06890
gene id: 399550:SMAR_RS06890
uniprot id: A3DP55
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

399550:SMAR RS05665
gene id: 399550:SMAR_RS05665
uniprot id: A3DNH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

399550:SMAR RS06495
gene id: 399550:SMAR_RS06495
uniprot id: A3DNX9
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

399550:SMAR RS04215
gene id: 399550:SMAR_RS04215
uniprot id: A3DMQ9
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

399550:SMAR RS05860
gene id: 399550:SMAR_RS05860
uniprot id: A3DNL5
names: Similarity
messages: Belongs to the UPF0111 family.

399550:SMAR RS04175
gene id: 399550:SMAR_RS04175
uniprot id: A3DMQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

399550:SMAR RS00010
gene id: 399550:SMAR_RS00010
uniprot id: A3DKF6
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS00995
gene id: 399550:SMAR_RS00995
uniprot id: A3DL01
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

399550:SMAR RS06680
gene id: 399550:SMAR_RS06680
uniprot id: A3DP13
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

399550:SMAR RS00895
gene id: 399550:SMAR_RS00895
uniprot id: A3DKY1
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

399550:SMAR RS00470
gene id: 399550:SMAR_RS00470
uniprot id: A3DKP7
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

399550:SMAR RS03520
gene id: 399550:SMAR_RS03520
uniprot id: A3DMD0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

399550:SMAR RS05125
gene id: 399550:SMAR_RS05125
uniprot id: A3DN77
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

399550:SMAR RS01935
gene id: 399550:SMAR_RS01935
uniprot id: A3DLI5
names: Similarity
messages: Belongs to the ZPR1 family.

399550:SMAR RS06945
gene id: 399550:SMAR_RS06945
uniprot id: A3DP66
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

399550:SMAR RS00255
gene id: 399550:SMAR_RS00255
uniprot id: A3DKK5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

399550:SMAR RS02495
gene id: 399550:SMAR_RS02495
uniprot id: A3DLU2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

399550:SMAR RS03840
gene id: 399550:SMAR_RS03840
uniprot id: A3DMJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.

399550:SMAR RS03285
gene id: 399550:SMAR_RS03285
uniprot id: A3DM89
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

399550:SMAR RS05150
gene id: 399550:SMAR_RS05150
uniprot id: A3DN81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

399550:SMAR RS02250
gene id: 399550:SMAR_RS02250
uniprot id: A3DLP7
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

399550:SMAR RS07010
gene id: 399550:SMAR_RS07010
uniprot id: A3DP79
names: Similarity
messages: Belongs to the peptidase U62 family.

399550:SMAR RS00590
gene id: 399550:SMAR_RS00590
uniprot id: A3DKS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

399550:SMAR RS05305
gene id: 399550:SMAR_RS05305
uniprot id: A3DNB3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

399550:SMAR RS02185
gene id: 399550:SMAR_RS02185
uniprot id: A3DLN4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

399550:SMAR RS03310
gene id: 399550:SMAR_RS03310
uniprot id: A3DM94
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

399550:SMAR RS06065
gene id: 399550:SMAR_RS06065
uniprot id: A3DNP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

399550:SMAR RS01160
gene id: 399550:SMAR_RS01160
uniprot id: A3DL34
names: Similarity
messages: Belongs to the UPF0282 family.

399550:SMAR RS01765
gene id: 399550:SMAR_RS01765
uniprot id: A3DLF2
names: Domain
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.
messages: Involved in DNA damage repair.

399550:SMAR RS00890
gene id: 399550:SMAR_RS00890
uniprot id: A3DKY0
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

399550:SMAR RS04825
gene id: 399550:SMAR_RS04825
uniprot id: A3DN20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

399550:SMAR RS07645
gene id: 399550:SMAR_RS07645
uniprot id: A3DPK1
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS00285
gene id: 399550:SMAR_RS00285
uniprot id: A3DKL1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

399550:SMAR RS05645
gene id: 399550:SMAR_RS05645
uniprot id: A3DNH6
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

399550:SMAR RS06555
gene id: 399550:SMAR_RS06555
uniprot id: A3DNZ1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

399550:SMAR RS00980
gene id: 399550:SMAR_RS00980
uniprot id: A3DKZ8
names: Similarity
messages: Belongs to the glutaredoxin family.

399550:SMAR RS00565
gene id: 399550:SMAR_RS00565
uniprot id: A3DKR6
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS05105
gene id: 399550:SMAR_RS05105
uniprot id: A3DN74
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

399550:SMAR RS03065
gene id: 399550:SMAR_RS03065
uniprot id: A3DM51
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

399550:SMAR RS05815
gene id: 399550:SMAR_RS05815
uniprot id: A3DNK7
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

399550:SMAR RS07240
gene id: 399550:SMAR_RS07240
uniprot id: A3DPC3
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

399550:SMAR RS04890
gene id: 399550:SMAR_RS04890
uniprot id: A3DN32
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

399550:SMAR RS06380
gene id: 399550:SMAR_RS06380
uniprot id: A3DNV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

399550:SMAR RS06935
gene id: 399550:SMAR_RS06935
uniprot id: A3DP64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

399550:SMAR RS06525
gene id: 399550:SMAR_RS06525
uniprot id: A3DNY5
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

399550:SMAR RS05715
gene id: 399550:SMAR_RS05715
uniprot id: A3DNI8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

399550:SMAR RS03200
gene id: 399550:SMAR_RS03200
uniprot id: A3DM74
names: Function
names: Similarity
messages: Belongs to the FAU-1 family.
messages: Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.

399550:SMAR RS00770
gene id: 399550:SMAR_RS00770
uniprot id: A3DKV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

399550:SMAR RS06340
gene id: 399550:SMAR_RS06340
uniprot id: A3DNV0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

399550:SMAR RS04260
gene id: 399550:SMAR_RS04260
uniprot id: A3DMR8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

399550:SMAR RS05785
gene id: 399550:SMAR_RS05785
uniprot id: A3DNK1
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

399550:SMAR RS06130
gene id: 399550:SMAR_RS06130
uniprot id: A3DNR0
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS04140
gene id: 399550:SMAR_RS04140
uniprot id: A3DMP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

399550:SMAR RS05295
gene id: 399550:SMAR_RS05295
uniprot id: A3DNB1
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

399550:SMAR RS02090
gene id: 399550:SMAR_RS02090
uniprot id: A3DLL4
names: Similarity
messages: Belongs to the MtrH family.

399550:SMAR RS07265
gene id: 399550:SMAR_RS07265
uniprot id: A3DPC8
names: Similarity
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.

399550:SMAR RS01375
gene id: 399550:SMAR_RS01375
uniprot id: A3DL77
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

399550:SMAR RS01205
gene id: 399550:SMAR_RS01205
uniprot id: A3DL43
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

399550:SMAR RS00445
gene id: 399550:SMAR_RS00445
uniprot id: A3DKP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

399550:SMAR RS05825
gene id: 399550:SMAR_RS05825
uniprot id: A3DNK9
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

399550:SMAR RS00555
gene id: 399550:SMAR_RS00555
uniprot id: A3DKR4
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS00775
gene id: 399550:SMAR_RS00775
uniprot id: A3DKV7
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS05180
gene id: 399550:SMAR_RS05180
uniprot id: A3DN87
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

399550:SMAR RS06510
gene id: 399550:SMAR_RS06510
uniprot id: A3DNY2
names: Similarity
messages: Belongs to the TFIIB family.

399550:SMAR RS07175
gene id: 399550:SMAR_RS07175
uniprot id: A3DPB0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

399550:SMAR RS04450
gene id: 399550:SMAR_RS04450
uniprot id: A3DMV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

399550:SMAR RS01095
gene id: 399550:SMAR_RS01095
uniprot id: A3DL21
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

399550:SMAR RS07890
gene id: 399550:SMAR_RS07890
uniprot id: A3DPQ0
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.

399550:SMAR RS02205
gene id: 399550:SMAR_RS02205
uniprot id: A3DLN8
names: Similarity
messages: Belongs to the BtpA family.

399550:SMAR RS04170
gene id: 399550:SMAR_RS04170
uniprot id: A3DMQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

399550:SMAR RS07090
gene id: 399550:SMAR_RS07090
uniprot id: A3DP94
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

399550:SMAR RS02055
gene id: 399550:SMAR_RS02055
uniprot id: A3DLK9
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

399550:SMAR RS06030
gene id: 399550:SMAR_RS06030
uniprot id: A3DNP0
names: Subcellular Location Annotation
messages: Cell membrane

399550:SMAR RS00245
gene id: 399550:SMAR_RS00245
uniprot id: A3DKK3
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

399550:SMAR RS05335
gene id: 399550:SMAR_RS05335
uniprot id: A3DNB9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

399550:SMAR RS05820
gene id: 399550:SMAR_RS05820
uniprot id: A3DNK8
names: Similarity
messages: Belongs to the UPF0273 family.

399550:SMAR RS08000
gene id: 399550:SMAR_RS08000
uniprot id: A3DPR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

399550:SMAR RS07840
gene id: 399550:SMAR_RS07840
uniprot id: A3DPP0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

399550:SMAR RS04595
gene id: 399550:SMAR_RS04595
uniprot id: A3DMY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

399550:SMAR RS04220
gene id: 399550:SMAR_RS04220
uniprot id: A3DMR0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

399550:SMAR RS03980
gene id: 399550:SMAR_RS03980
uniprot id: A3DML6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

399550:SMAR RS05695
gene id: 399550:SMAR_RS05695
uniprot id: A3DNI4
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS04990
gene id: 399550:SMAR_RS04990
uniprot id: A3DN51
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

399550:SMAR RS00340
gene id: 399550:SMAR_RS00340
uniprot id: A3DKM2
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

399550:SMAR RS04755
gene id: 399550:SMAR_RS04755
uniprot id: A3DN08
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

399550:SMAR RS06430
gene id: 399550:SMAR_RS06430
uniprot id: A3DNW6
names: Similarity
messages: Belongs to the UPF0200 family.

399550:SMAR RS04300
gene id: 399550:SMAR_RS04300
uniprot id: A3DMS6
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

399550:SMAR RS05440
gene id: 399550:SMAR_RS05440
uniprot id: A3DNE0
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

399550:SMAR RS04125
gene id: 399550:SMAR_RS04125
uniprot id: A3DMP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

399550:SMAR RS04195
gene id: 399550:SMAR_RS04195
uniprot id: A3DMQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

399550:SMAR RS00065
gene id: 399550:SMAR_RS00065
uniprot id: A3DKG7
names: Similarity
messages: Belongs to the HupF/HypC family.

399550:SMAR RS03250
gene id: 399550:SMAR_RS03250
uniprot id: A3DM82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

399550:SMAR RS02530
gene id: 399550:SMAR_RS02530
uniprot id: A3DLU9
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

399550:SMAR RS04095
gene id: 399550:SMAR_RS04095
uniprot id: A3DMN7
names: Similarity
messages: Belongs to the UPF0215 family.

399550:SMAR RS08235
gene id: 399550:SMAR_RS08235
uniprot id: A3DPW2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

399550:SMAR RS03380
gene id: 399550:SMAR_RS03380
uniprot id: A3DMA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

399550:SMAR RS04865
gene id: 399550:SMAR_RS04865
uniprot id: A3DN28
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm
messages: Homodimer.

399550:SMAR RS05390
gene id: 399550:SMAR_RS05390
uniprot id: A3DND0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

399550:SMAR RS04430
gene id: 399550:SMAR_RS04430
uniprot id: A3DMV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

399550:SMAR RS06390
gene id: 399550:SMAR_RS06390
uniprot id: A3DNW0
names: Subcellular Location Annotation
messages: Nucleus

399550:SMAR RS01500
gene id: 399550:SMAR_RS01500
uniprot id: A3DLA1
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

399550:SMAR RS04255
gene id: 399550:SMAR_RS04255
uniprot id: A3DMR7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

399550:SMAR RS00120
gene id: 399550:SMAR_RS00120
uniprot id: A3DKH8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

399550:SMAR RS00440
gene id: 399550:SMAR_RS00440
uniprot id: A3DKP1
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS05365
gene id: 399550:SMAR_RS05365
uniprot id: A3DNC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

399550:SMAR RS00600
gene id: 399550:SMAR_RS00600
uniprot id: A3DKS3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

399550:SMAR RS04740
gene id: 399550:SMAR_RS04740
uniprot id: A3DN05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

399550:SMAR RS07185
gene id: 399550:SMAR_RS07185
uniprot id: A3DPB2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

399550:SMAR RS06725
gene id: 399550:SMAR_RS06725
uniprot id: A3DP22
names: Similarity
messages: Belongs to the RuvB family.

399550:SMAR RS05680
gene id: 399550:SMAR_RS05680
uniprot id: A3DNI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

399550:SMAR RS04015
gene id: 399550:SMAR_RS04015
uniprot id: A3DMM3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

399550:SMAR RS05020
gene id: 399550:SMAR_RS05020
uniprot id: A3DN57
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

399550:SMAR RS00910
gene id: 399550:SMAR_RS00910
uniprot id: A3DKY4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

399550:SMAR RS01485
gene id: 399550:SMAR_RS01485
uniprot id: A3DL98
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

399550:SMAR RS00695
gene id: 399550:SMAR_RS00695
uniprot id: A3DKU1
names: Similarity
messages: Belongs to the peptidase M20A family.

399550:SMAR RS06865
gene id: 399550:SMAR_RS06865
uniprot id: A3DP50
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

399550:SMAR RS05265
gene id: 399550:SMAR_RS05265
uniprot id: A3DNA5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

399550:SMAR RS02725
gene id: 399550:SMAR_RS02725
uniprot id: A3DLY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

399550:SMAR RS02510
gene id: 399550:SMAR_RS02510
uniprot id: A3DLU5
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

399550:SMAR RS06520
gene id: 399550:SMAR_RS06520
uniprot id: A3DNY4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

399550:SMAR RS04715
gene id: 399550:SMAR_RS04715
uniprot id: A3DN00
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

399550:SMAR RS00030
gene id: 399550:SMAR_RS00030
uniprot id: A3DKG0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

399550:SMAR RS04055
gene id: 399550:SMAR_RS04055
uniprot id: A3DMN1
names: Similarity
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.

399550:SMAR RS01970
gene id: 399550:SMAR_RS01970
uniprot id: A3DLJ2
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

399550:SMAR RS07280
gene id: 399550:SMAR_RS07280
uniprot id: A3DPD1
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS00280
gene id: 399550:SMAR_RS00280
uniprot id: A3DKL0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

399550:SMAR RS02045
gene id: 399550:SMAR_RS02045
uniprot id: A3DLK7
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

399550:SMAR RS02335
gene id: 399550:SMAR_RS02335
uniprot id: A3DLR1
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

399550:SMAR RS05755
gene id: 399550:SMAR_RS05755
uniprot id: A3DNJ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

399550:SMAR RS06145
gene id: 399550:SMAR_RS06145
uniprot id: A3DNR3
names: Similarity
messages: Belongs to the UPF0216 family.

399550:SMAR RS06230
gene id: 399550:SMAR_RS06230
uniprot id: A3DNT0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

399550:SMAR RS06135
gene id: 399550:SMAR_RS06135
uniprot id: A3DNR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

399550:SMAR RS04275
gene id: 399550:SMAR_RS04275
uniprot id: A3DMS1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

399550:SMAR RS03675
gene id: 399550:SMAR_RS03675
uniprot id: A3DMG0
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

399550:SMAR RS06385
gene id: 399550:SMAR_RS06385
uniprot id: A3DNV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

399550:SMAR RS04165
gene id: 399550:SMAR_RS04165
uniprot id: A3DMQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

399550:SMAR RS06360
gene id: 399550:SMAR_RS06360
uniprot id: A3DNV4
names: Function
messages: Part of a potassium transport system.

399550:SMAR RS04690
gene id: 399550:SMAR_RS04690
uniprot id: A3DMZ7
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

399550:SMAR RS05540
gene id: 399550:SMAR_RS05540
uniprot id: A3DNF8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

399550:SMAR RS07190
gene id: 399550:SMAR_RS07190
uniprot id: A3DPB3
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

399550:SMAR RS04270
gene id: 399550:SMAR_RS04270
uniprot id: A3DMS0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

399550:SMAR RS05640
gene id: 399550:SMAR_RS05640
uniprot id: A3DNH5
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

399550:SMAR RS06760
gene id: 399550:SMAR_RS06760
uniprot id: A3DP29
names: Caution
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

399550:SMAR RS04400
gene id: 399550:SMAR_RS04400
uniprot id: A3DMU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

399550:SMAR RS03865
gene id: 399550:SMAR_RS03865
uniprot id: A3DMJ6
names: Similarity
messages: Belongs to the UPF0145 family.

399550:SMAR RS06325
gene id: 399550:SMAR_RS06325
uniprot id: A3DNU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

399550:SMAR RS05830
gene id: 399550:SMAR_RS05830
uniprot id: A3DNL0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

399550:SMAR RS03055
gene id: 399550:SMAR_RS03055
uniprot id: A3DM49
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

399550:SMAR RS03530
gene id: 399550:SMAR_RS03530
uniprot id: A3DMD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

399550:SMAR RS07045
gene id: 399550:SMAR_RS07045
uniprot id: A3DP85
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

399550:SMAR RS05795
gene id: 399550:SMAR_RS05795
uniprot id: A3DNK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

399550:SMAR RS06845
gene id: 399550:SMAR_RS06845
uniprot id: A3DP46
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS07315
gene id: 399550:SMAR_RS07315
uniprot id: A3DPD7
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

399550:SMAR RS04425
gene id: 399550:SMAR_RS04425
uniprot id: A3DMU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

399550:SMAR RS01615
gene id: 399550:SMAR_RS01615
uniprot id: A3DLC4
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

399550:SMAR RS02080
gene id: 399550:SMAR_RS02080
uniprot id: A3DLL2
names: Similarity
messages: Belongs to the peptidase S9C family.

399550:SMAR RS06605
gene id: 399550:SMAR_RS06605
uniprot id: A3DP00
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

399550:SMAR RS07535
gene id: 399550:SMAR_RS07535
uniprot id: A3DPI0
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

399550:SMAR RS05370
gene id: 399550:SMAR_RS05370
uniprot id: A3DNC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

399550:SMAR RS06035
gene id: 399550:SMAR_RS06035
uniprot id: A3DNP1
names: Similarity
messages: Belongs to the PGI/PMI family.

399550:SMAR RS01710
gene id: 399550:SMAR_RS01710
uniprot id: A3DLE1
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

399550:SMAR RS03220
gene id: 399550:SMAR_RS03220
uniprot id: A3DM77
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

399550:SMAR RS02615
gene id: 399550:SMAR_RS02615
uniprot id: A3DLW6
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

399550:SMAR RS02190
gene id: 399550:SMAR_RS02190
uniprot id: A3DLN5
names: Similarity
messages: Belongs to the peptidase S8 family.

399550:SMAR RS01235
gene id: 399550:SMAR_RS01235
uniprot id: A3DL49
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

399550:SMAR RS06355
gene id: 399550:SMAR_RS06355
uniprot id: A3DNV3
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS03260
gene id: 399550:SMAR_RS03260
uniprot id: A3DM84
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

399550:SMAR RS00845
gene id: 399550:SMAR_RS00845
uniprot id: A3DKX1
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS04415
gene id: 399550:SMAR_RS04415
uniprot id: A3DMU7
names: Similarity
messages: Belongs to the SDO1/SBDS family.

399550:SMAR RS04290
gene id: 399550:SMAR_RS04290
uniprot id: A3DMS4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

399550:SMAR RS05605
gene id: 399550:SMAR_RS05605
uniprot id: A3DNG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

399550:SMAR RS08280
gene id: 399550:SMAR_RS08280
uniprot id: A3DPX0
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

399550:SMAR RS03300
gene id: 399550:SMAR_RS03300
uniprot id: A3DM92
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

399550:SMAR RS03905
gene id: 399550:SMAR_RS03905
uniprot id: A3DMK3
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

399550:SMAR RS06485
gene id: 399550:SMAR_RS06485
uniprot id: A3DNX7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

399550:SMAR RS03690
gene id: 399550:SMAR_RS03690
uniprot id: A3DMG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

399550:SMAR RS04580
gene id: 399550:SMAR_RS04580
uniprot id: A3DMX7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

399550:SMAR RS03670
gene id: 399550:SMAR_RS03670
uniprot id: A3DMF9
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

399550:SMAR RS06260
gene id: 399550:SMAR_RS06260
uniprot id: A3DNT5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).

399550:SMAR RS01120
gene id: 399550:SMAR_RS01120
uniprot id: A3DL26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

399550:SMAR RS05400
gene id: 399550:SMAR_RS05400
uniprot id: A3DND2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

399550:SMAR RS05110
gene id: 399550:SMAR_RS05110
uniprot id: A3DN75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

399550:SMAR RS04645
gene id: 399550:SMAR_RS04645
uniprot id: A3DMY9
names: Similarity
messages: Belongs to the pyruvate kinase family.

399550:SMAR RS05010
gene id: 399550:SMAR_RS05010
uniprot id: A3DN55
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

399550:SMAR RS06435
gene id: 399550:SMAR_RS06435
uniprot id: A3DNW7
names: Similarity
messages: Belongs to the UPF0201 family.

399550:SMAR RS04145
gene id: 399550:SMAR_RS04145
uniprot id: A3DMP6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

399550:SMAR RS00920
gene id: 399550:SMAR_RS00920
uniprot id: A3DKY6
names: Similarity
messages: Belongs to the glutamine synthetase family.

399550:SMAR RS05675
gene id: 399550:SMAR_RS05675
uniprot id: A3DNI1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

399550:SMAR RS01210
gene id: 399550:SMAR_RS01210
uniprot id: A3DL44
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

399550:SMAR RS03140
gene id: 399550:SMAR_RS03140
uniprot id: A3DM62
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

399550:SMAR RS05080
gene id: 399550:SMAR_RS05080
uniprot id: A3DN69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

399550:SMAR RS06880
gene id: 399550:SMAR_RS06880
uniprot id: A3DP53
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

399550:SMAR RS00270
gene id: 399550:SMAR_RS00270
uniprot id: A3DKK8
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS04295
gene id: 399550:SMAR_RS04295
uniprot id: A3DMS5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

399550:SMAR RS00360
gene id: 399550:SMAR_RS00360
uniprot id: A3DKM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

399550:SMAR RS03715
gene id: 399550:SMAR_RS03715
uniprot id: A3DMG8
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs.

399550:SMAR RS05145
gene id: 399550:SMAR_RS05145
uniprot id: A3DN80
names: Subcellular Location Annotation
messages: Nucleus

399550:SMAR RS01735
gene id: 399550:SMAR_RS01735
uniprot id: A3DLE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

399550:SMAR RS07500
gene id: 399550:SMAR_RS07500
uniprot id: A3DPH3
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

399550:SMAR RS01930
gene id: 399550:SMAR_RS01930
uniprot id: A3DLI4
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

399550:SMAR RS06440
gene id: 399550:SMAR_RS06440
uniprot id: A3DNW8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

399550:SMAR RS05970
gene id: 399550:SMAR_RS05970
uniprot id: A3DNN1
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS01525
gene id: 399550:SMAR_RS01525
uniprot id: A3DLA6
names: Similarity
messages: Belongs to the MoaB/Mog family.

399550:SMAR RS00115
gene id: 399550:SMAR_RS00115
uniprot id: A3DKH7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

399550:SMAR RS03565
gene id: 399550:SMAR_RS03565
uniprot id: A3DMD9
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS03330
gene id: 399550:SMAR_RS03330
uniprot id: A3DM98
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

399550:SMAR RS06500
gene id: 399550:SMAR_RS06500
uniprot id: A3DNY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

399550:SMAR RS03340
gene id: 399550:SMAR_RS03340
uniprot id: A3DMA0
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS03985
gene id: 399550:SMAR_RS03985
uniprot id: A3DML7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

399550:SMAR RS07180
gene id: 399550:SMAR_RS07180
uniprot id: A3DPB1
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

399550:SMAR RS06185
gene id: 399550:SMAR_RS06185
uniprot id: A3DNS1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Binds 2 Mg(2+) or Mn(2+) ions per subunit.
messages: Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

399550:SMAR RS07725
gene id: 399550:SMAR_RS07725
uniprot id: A3DPL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

399550:SMAR RS04005
gene id: 399550:SMAR_RS04005
uniprot id: A3DMM1
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

399550:SMAR RS06420
gene id: 399550:SMAR_RS06420
uniprot id: A3DNW4
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

399550:SMAR RS01125
gene id: 399550:SMAR_RS01125
uniprot id: A3DL27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.

399550:SMAR RS00130
gene id: 399550:SMAR_RS00130
uniprot id: A3DKI0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

399550:SMAR RS01430
gene id: 399550:SMAR_RS01430
uniprot id: A3DL88
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS04895
gene id: 399550:SMAR_RS04895
uniprot id: A3DN33
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.

399550:SMAR RS01340
gene id: 399550:SMAR_RS01340
uniprot id: A3DL70
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

399550:SMAR RS05945
gene id: 399550:SMAR_RS05945
uniprot id: A3DNM7
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

399550:SMAR RS05880
gene id: 399550:SMAR_RS05880
uniprot id: A3DNL9
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

399550:SMAR RS02445
gene id: 399550:SMAR_RS02445
uniprot id: A3DLT2
names: Similarity
messages: Belongs to the CutA family.

399550:SMAR RS06180
gene id: 399550:SMAR_RS06180
uniprot id: A3DNS0
names: Similarity
messages: Belongs to the AP endonuclease 2 family.

399550:SMAR RS05760
gene id: 399550:SMAR_RS05760
uniprot id: A3DNJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

399550:SMAR RS01700
gene id: 399550:SMAR_RS01700
uniprot id: A3DLD9
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

399550:SMAR RS03360
gene id: 399550:SMAR_RS03360
uniprot id: A3DMA4
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS04495
gene id: 399550:SMAR_RS04495
uniprot id: A3DMW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

399550:SMAR RS00205
gene id: 399550:SMAR_RS00205
uniprot id: A3DKJ5
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

399550:SMAR RS00795
gene id: 399550:SMAR_RS00795
uniprot id: A3DKW1
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

399550:SMAR RS01105
gene id: 399550:SMAR_RS01105
uniprot id: A3DL23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

399550:SMAR RS05385
gene id: 399550:SMAR_RS05385
uniprot id: A3DNC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

399550:SMAR RS04320
gene id: 399550:SMAR_RS04320
uniprot id: A3DMT0
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

399550:SMAR RS04410
gene id: 399550:SMAR_RS04410
uniprot id: A3DMU6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

399550:SMAR RS07210
gene id: 399550:SMAR_RS07210
uniprot id: A3DPB7
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS00295
gene id: 399550:SMAR_RS00295
uniprot id: A3DKL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

399550:SMAR RS04810
gene id: 399550:SMAR_RS04810
uniprot id: A3DN18
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

399550:SMAR RS01410
gene id: 399550:SMAR_RS01410
uniprot id: A3DL84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

399550:SMAR RS06460
gene id: 399550:SMAR_RS06460
uniprot id: A3DNX2
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

399550:SMAR RS02375
gene id: 399550:SMAR_RS02375
uniprot id: A3DLR9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

399550:SMAR RS01520
gene id: 399550:SMAR_RS01520
uniprot id: A3DLA5
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS04545
gene id: 399550:SMAR_RS04545
uniprot id: A3DMX1
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS02390
gene id: 399550:SMAR_RS02390
uniprot id: A3DLS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

399550:SMAR RS00645
gene id: 399550:SMAR_RS00645
uniprot id: A3DKT1
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS05340
gene id: 399550:SMAR_RS05340
uniprot id: A3DNC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

399550:SMAR RS06105
gene id: 399550:SMAR_RS06105
uniprot id: A3DNQ5
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

399550:SMAR RS05435
gene id: 399550:SMAR_RS05435
uniprot id: A3DND9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

399550:SMAR RS04500
gene id: 399550:SMAR_RS04500
uniprot id: A3DMW2
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

399550:SMAR RS06255
gene id: 399550:SMAR_RS06255
uniprot id: A3DNT4
names: Similarity
messages: Belongs to the AOR/FOR family.

399550:SMAR RS07720
gene id: 399550:SMAR_RS07720
uniprot id: A3DPL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

399550:SMAR RS05885
gene id: 399550:SMAR_RS05885
uniprot id: A3DNM0
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

399550:SMAR RS08085
gene id: 399550:SMAR_RS08085
uniprot id: A3DPT4
names: Similarity
messages: Belongs to the HepT RNase toxin family.

399550:SMAR RS04310
gene id: 399550:SMAR_RS04310
uniprot id: A3DMS8
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

399550:SMAR RS05410
gene id: 399550:SMAR_RS05410
uniprot id: A3DND4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

399550:SMAR RS04250
gene id: 399550:SMAR_RS04250
uniprot id: A3DMR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

399550:SMAR RS04100
gene id: 399550:SMAR_RS04100
uniprot id: A3DMN8
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

399550:SMAR RS01370
gene id: 399550:SMAR_RS01370
uniprot id: A3DL76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

399550:SMAR RS05585
gene id: 399550:SMAR_RS05585
uniprot id: A3DNG5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.

399550:SMAR RS04105
gene id: 399550:SMAR_RS04105
uniprot id: A3DMN9
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

399550:SMAR RS02245
gene id: 399550:SMAR_RS02245
uniprot id: A3DLP6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

399550:SMAR RS05515
gene id: 399550:SMAR_RS05515
uniprot id: A3DNF3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

399550:SMAR RS03035
gene id: 399550:SMAR_RS03035
uniprot id: A3DM46
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

399550:SMAR RS04325
gene id: 399550:SMAR_RS04325
uniprot id: A3DMT1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

399550:SMAR RS03355
gene id: 399550:SMAR_RS03355
uniprot id: A3DMA3
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS04280
gene id: 399550:SMAR_RS04280
uniprot id: A3DMS2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

399550:SMAR RS01915
gene id: 399550:SMAR_RS01915
uniprot id: A3DLI1
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

399550:SMAR RS04190
gene id: 399550:SMAR_RS04190
uniprot id: A3DMQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

399550:SMAR RS03185
gene id: 399550:SMAR_RS03185
uniprot id: A3DM71
names: Similarity
messages: Belongs to the thymidylate kinase family.

399550:SMAR RS05775
gene id: 399550:SMAR_RS05775
uniprot id: A3DNJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

399550:SMAR RS01775
gene id: 399550:SMAR_RS01775
uniprot id: A3DLF4
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

399550:SMAR RS07905
gene id: 399550:SMAR_RS07905
uniprot id: A3DPQ3
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS06535
gene id: 399550:SMAR_RS06535
uniprot id: A3DNY7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

399550:SMAR RS05355
gene id: 399550:SMAR_RS05355
uniprot id: A3DNC3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

399550:SMAR RS00710
gene id: 399550:SMAR_RS00710
uniprot id: P46893
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.
messages: Homooligomer. Forms a large complex of about 2000 kDa.
messages: The N-terminal domain contains the ATP/Pi binding site, the central domain the pyrophosphate/phosphate carrier histidine, and the C-terminal domain the pyruvate binding site.
messages: The N-terminus is blocked.
messages: The reaction takes place in three steps, mediated by a phosphocarrier histidine residue located on the surface of the central domain. The two first partial reactions are catalyzed at an active site located on the N-terminal domain, and the third partial reaction is catalyzed at an active site located on the C-terminal domain. For catalytic turnover, the central domain swivels from the concave surface of the N-terminal domain to that of the C-terminal domain (By similarity).

399550:SMAR RS05360
gene id: 399550:SMAR_RS05360
uniprot id: A3DNC4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

399550:SMAR RS05620
gene id: 399550:SMAR_RS05620
uniprot id: A3DNH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

399550:SMAR RS02155
gene id: 399550:SMAR_RS02155
uniprot id: A3DLM8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

399550:SMAR RS05975
gene id: 399550:SMAR_RS05975
uniprot id: A3DNN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

399550:SMAR RS06540
gene id: 399550:SMAR_RS06540
uniprot id: A3DNY8
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

399550:SMAR RS04845
gene id: 399550:SMAR_RS04845
uniprot id: A3DN24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

399550:SMAR RS02525
gene id: 399550:SMAR_RS02525
uniprot id: A3DLU8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Heterooctamer of four alpha and four beta chains arranged as a tetramer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.
messages: Specifically catalyzes the decarboxylation of L-arginine to agmatine. Has no S-adenosylmethionine decarboxylase (AdoMetDC) activity.

399550:SMAR RS07270
gene id: 399550:SMAR_RS07270
uniprot id: A3DPC9
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS08285
gene id: 399550:SMAR_RS08285
uniprot id: A3DPX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

399550:SMAR RS04775
gene id: 399550:SMAR_RS04775
uniprot id: A3DN12
names: Similarity
messages: Belongs to the PstS family.

399550:SMAR RS00020
gene id: 399550:SMAR_RS00020
uniprot id: A3DKF8
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS04685
gene id: 399550:SMAR_RS04685
uniprot id: A3DMZ6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

399550:SMAR RS05315
gene id: 399550:SMAR_RS05315
uniprot id: A3DNB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

399550:SMAR RS01195
gene id: 399550:SMAR_RS01195
uniprot id: A3DL41
names: Similarity
messages: Belongs to the dihydropyrimidine dehydrogenase family.

399550:SMAR RS02480
gene id: 399550:SMAR_RS02480
uniprot id: A3DLT9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

399550:SMAR RS04205
gene id: 399550:SMAR_RS04205
uniprot id: A3DMQ7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

399550:SMAR RS00400
gene id: 399550:SMAR_RS00400
uniprot id: A3DKN3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

399550:SMAR RS02790
gene id: 399550:SMAR_RS02790
uniprot id: A3DM00
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

399550:SMAR RS00325
gene id: 399550:SMAR_RS00325
uniprot id: A3DKL9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

399550:SMAR RS04345
gene id: 399550:SMAR_RS04345
uniprot id: A3DMT5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

399550:SMAR RS03265
gene id: 399550:SMAR_RS03265
uniprot id: A3DM85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).

399550:SMAR RS04200
gene id: 399550:SMAR_RS04200
uniprot id: A3DMQ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

399550:SMAR RS04465
gene id: 399550:SMAR_RS04465
uniprot id: A3DMV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

399550:SMAR RS01470
gene id: 399550:SMAR_RS01470
uniprot id: A3DL95
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer composed of an alpha and a beta subunit.
messages: Heterodimer of the IorA and IorB subunits.

399550:SMAR RS03290
gene id: 399550:SMAR_RS03290
uniprot id: A3DM90
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

399550:SMAR RS04010
gene id: 399550:SMAR_RS04010
uniprot id: A3DMM2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.

399550:SMAR RS02570
gene id: 399550:SMAR_RS02570
uniprot id: A3DLV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

399550:SMAR RS04600
gene id: 399550:SMAR_RS04600
uniprot id: A3DMY1
names: Similarity
messages: Belongs to the UPF0173 family.

399550:SMAR RS03620
gene id: 399550:SMAR_RS03620
uniprot id: A3DME9
names: Similarity
messages: Belongs to the glycosyl hydrolase 4 family.

399550:SMAR RS05405
gene id: 399550:SMAR_RS05405
uniprot id: A3DND3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

399550:SMAR RS06670
gene id: 399550:SMAR_RS06670
uniprot id: A3DP11
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

399550:SMAR RS01325
gene id: 399550:SMAR_RS01325
uniprot id: A3DL67
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

399550:SMAR RS02455
gene id: 399550:SMAR_RS02455
uniprot id: A3DLT4
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

399550:SMAR RS05525
gene id: 399550:SMAR_RS05525
uniprot id: A3DNF5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

399550:SMAR RS05300
gene id: 399550:SMAR_RS05300
uniprot id: A3DNB2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

399550:SMAR RS00125
gene id: 399550:SMAR_RS00125
uniprot id: A3DKH9
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS05330
gene id: 399550:SMAR_RS05330
uniprot id: A3DNB8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

399550:SMAR RS04850
gene id: 399550:SMAR_RS04850
uniprot id: A3DN25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

399550:SMAR RS05060
gene id: 399550:SMAR_RS05060
uniprot id: A3DN65
names: Caution
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

399550:SMAR RS02660
gene id: 399550:SMAR_RS02660
uniprot id: A3DLX4
names: Similarity
messages: Belongs to the UPF0235 family.

399550:SMAR RS05445
gene id: 399550:SMAR_RS05445
uniprot id: A3DNE1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M54 family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.
messages: Monomer.
messages: Probable zinc metalloprotease whose natural substrate is unknown.

399550:SMAR RS01740
gene id: 399550:SMAR_RS01740
uniprot id: A3DLE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

399550:SMAR RS04210
gene id: 399550:SMAR_RS04210
uniprot id: A3DMQ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

399550:SMAR RS00025
gene id: 399550:SMAR_RS00025
uniprot id: A3DKF9
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

399550:SMAR RS03335
gene id: 399550:SMAR_RS03335
uniprot id: A3DM99
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

399550:SMAR RS08290
gene id: 399550:SMAR_RS08290
uniprot id: A3DPX2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

399550:SMAR RS03425
gene id: 399550:SMAR_RS03425
uniprot id: A3DMB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

399550:SMAR RS05710
gene id: 399550:SMAR_RS05710
uniprot id: A3DNI7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

399550:SMAR RS05915
gene id: 399550:SMAR_RS05915
uniprot id: A3DNM4
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS05160
gene id: 399550:SMAR_RS05160
uniprot id: A3DN83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

399550:SMAR RS04265
gene id: 399550:SMAR_RS04265
uniprot id: A3DMR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

399550:SMAR RS03510
gene id: 399550:SMAR_RS03510
uniprot id: A3DMC8
names: Similarity
messages: Belongs to the peptidase C15 family.

399550:SMAR RS03025
gene id: 399550:SMAR_RS03025
uniprot id: A3DM44
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

399550:SMAR RS04185
gene id: 399550:SMAR_RS04185
uniprot id: A3DMQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

399550:SMAR RS02650
gene id: 399550:SMAR_RS02650
uniprot id: A3DLX2
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

399550:SMAR RS00885
gene id: 399550:SMAR_RS00885
uniprot id: A3DKX9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

399550:SMAR RS01595
gene id: 399550:SMAR_RS01595
uniprot id: A3DLC0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

399550:SMAR RS00075
gene id: 399550:SMAR_RS00075
uniprot id: A3DKG9
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

399550:SMAR RS07335
gene id: 399550:SMAR_RS07335
uniprot id: A3DPE1
names: Similarity
messages: Belongs to the peptidase S8 family.

399550:SMAR RS03195
gene id: 399550:SMAR_RS03195
uniprot id: A3DM73
names: Similarity
messages: Belongs to the UPF0147 family.

399550:SMAR RS04440
gene id: 399550:SMAR_RS04440
uniprot id: A3DMV2
names: Function
messages: Probably involved in the biogenesis of the ribosome.

399550:SMAR RS02380
gene id: 399550:SMAR_RS02380
uniprot id: A3DLS0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

399550:SMAR RS02465
gene id: 399550:SMAR_RS02465
uniprot id: A3DLT6
names: Similarity
messages: Belongs to the DMRL synthase family.

399550:SMAR RS08175
gene id: 399550:SMAR_RS08175
uniprot id: A3DPV0
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

399550:SMAR RS02795
gene id: 399550:SMAR_RS02795
uniprot id: A3DM01
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

399550:SMAR RS02500
gene id: 399550:SMAR_RS02500
uniprot id: A3DLU3
names: Similarity
messages: Belongs to the UPF0251 family.

399550:SMAR RS07065
gene id: 399550:SMAR_RS07065
uniprot id: A3DP89
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

399550:SMAR RS02460
gene id: 399550:SMAR_RS02460
uniprot id: A3DLT5
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

399550:SMAR RS01945
gene id: 399550:SMAR_RS01945
uniprot id: A3DLI7
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

399550:SMAR RS04230
gene id: 399550:SMAR_RS04230
uniprot id: A3DMR2
names: Similarity
messages: Belongs to the MEMO1 family.

399550:SMAR RS03685
gene id: 399550:SMAR_RS03685
uniprot id: A3DMG2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

399550:SMAR RS02350
gene id: 399550:SMAR_RS02350
uniprot id: A3DLR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Cytoplasm

399550:SMAR RS04445
gene id: 399550:SMAR_RS04445
uniprot id: A3DMV3
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

399550:SMAR RS05630
gene id: 399550:SMAR_RS05630
uniprot id: A3DNH3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

399550:SMAR RS05325
gene id: 399550:SMAR_RS05325
uniprot id: A3DNB7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

399550:SMAR RS04780
gene id: 399550:SMAR_RS04780
uniprot id: A3DN13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

399550:SMAR RS03050
gene id: 399550:SMAR_RS03050
uniprot id: A3DM48
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

399550:SMAR RS03765
gene id: 399550:SMAR_RS03765
uniprot id: A3DMH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

399550:SMAR RS07560
gene id: 399550:SMAR_RS07560
uniprot id: A3DPI5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

399550:SMAR RS00685
gene id: 399550:SMAR_RS00685
uniprot id: A3DKT9
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

399550:SMAR RS00490
gene id: 399550:SMAR_RS00490
uniprot id: A3DKQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

399550:SMAR RS04225
gene id: 399550:SMAR_RS04225
uniprot id: A3DMR1
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

399550:SMAR RS05345
gene id: 399550:SMAR_RS05345
uniprot id: A3DNC1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

399550:SMAR RS06110
gene id: 399550:SMAR_RS06110
uniprot id: A3DNQ6
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

399550:SMAR RS00145
gene id: 399550:SMAR_RS00145
uniprot id: A3DKI3
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS03320
gene id: 399550:SMAR_RS03320
uniprot id: A3DM96
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

399550:SMAR RS00640
gene id: 399550:SMAR_RS00640
uniprot id: A3DKT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

399550:SMAR RS00835
gene id: 399550:SMAR_RS00835
uniprot id: A3DKW9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

399550:SMAR RS02010
gene id: 399550:SMAR_RS02010
uniprot id: A3DLK0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

399550:SMAR RS04660
gene id: 399550:SMAR_RS04660
uniprot id: A3DMZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

399550:SMAR RS05670
gene id: 399550:SMAR_RS05670
uniprot id: A3DNI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

399550:SMAR RS00620
gene id: 399550:SMAR_RS00620
uniprot id: A3DKS7
names: Similarity
messages: Belongs to the UPF0047 family.

399550:SMAR RS01590
gene id: 399550:SMAR_RS01590
uniprot id: A3DLB9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

399550:SMAR RS02850
gene id: 399550:SMAR_RS02850
uniprot id: A3DM10
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS05845
gene id: 399550:SMAR_RS05845
uniprot id: A3DNL3
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

399550:SMAR RS05275
gene id: 399550:SMAR_RS05275
uniprot id: A3DNA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

399550:SMAR RS05490
gene id: 399550:SMAR_RS05490
uniprot id: A3DNE8
names: Subcellular Location Annotation
messages: Membrane

399550:SMAR RS04385
gene id: 399550:SMAR_RS04385
uniprot id: A3DMU2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

399550:SMAR RS03165
gene id: 399550:SMAR_RS03165
uniprot id: A3DM67
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

399550:SMAR RS00225
gene id: 399550:SMAR_RS00225
uniprot id: A3DKJ9
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

399550:SMAR RS05375
gene id: 399550:SMAR_RS05375
uniprot id: A3DNC7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

399550:SMAR RS03040
gene id: 399550:SMAR_RS03040
uniprot id: A3DM47
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

399550:SMAR RS05655
gene id: 399550:SMAR_RS05655
uniprot id: A3DNH8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

399550:SMAR RS04305
gene id: 399550:SMAR_RS04305
uniprot id: A3DMS7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

399550:SMAR RS04870
gene id: 399550:SMAR_RS04870
uniprot id: A3DN29
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

399550:SMAR RS04665
gene id: 399550:SMAR_RS04665
uniprot id: A3DMZ2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

399550:SMAR RS04605
gene id: 399550:SMAR_RS04605
uniprot id: A3DMY2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

399550:SMAR RS05260
gene id: 399550:SMAR_RS05260
uniprot id: A3DNA4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

399550:SMAR RS01180
gene id: 399550:SMAR_RS01180
uniprot id: A3DL38
names: Similarity
messages: Belongs to the carbamate kinase family.

399550:SMAR RS07060
gene id: 399550:SMAR_RS07060
uniprot id: A3DP88
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

399550:SMAR RS05320
gene id: 399550:SMAR_RS05320
uniprot id: A3DNB6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

399550:SMAR RS00500
gene id: 399550:SMAR_RS00500
uniprot id: A3DKQ3
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

399550:SMAR RS05015
gene id: 399550:SMAR_RS05015
uniprot id: A3DN56
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

399550:SMAR RS00830
gene id: 399550:SMAR_RS00830
uniprot id: A3DKW8
names: Similarity
messages: Belongs to the UPF0111 family.

399550:SMAR RS00450
gene id: 399550:SMAR_RS00450
uniprot id: A3DKP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

399550:SMAR RS06000
gene id: 399550:SMAR_RS06000
uniprot id: A3DNN7
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

399550:SMAR RS06550
gene id: 399550:SMAR_RS06550
uniprot id: A3DNZ0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

399550:SMAR RS05085
gene id: 399550:SMAR_RS05085
uniprot id: A3DN70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

399550:SMAR RS06370
gene id: 399550:SMAR_RS06370
uniprot id: A3DNV6
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

399550:SMAR RS05350
gene id: 399550:SMAR_RS05350
uniprot id: A3DNC2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

399550:SMAR RS05380
gene id: 399550:SMAR_RS05380
uniprot id: A3DNC8
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

399550:SMAR RS01550
gene id: 399550:SMAR_RS01550
uniprot id: A3DLB1
names: Similarity
messages: Belongs to the CRISPR-associated Csm3 family.

399550:SMAR RS05310
gene id: 399550:SMAR_RS05310
uniprot id: A3DNB4
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

399550:SMAR RS05780
gene id: 399550:SMAR_RS05780
uniprot id: A3DNK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

399550:SMAR RS05175
gene id: 399550:SMAR_RS05175
uniprot id: A3DN86
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

399550:SMAR RS06850
gene id: 399550:SMAR_RS06850
uniprot id: A3DP47
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

399550:SMAR RS07525
gene id: 399550:SMAR_RS07525
uniprot id: A3DPH8
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

399550:SMAR RS02965
gene id: 399550:SMAR_RS02965
uniprot id: A3DM32
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

399550:SMAR RS04235
gene id: 399550:SMAR_RS04235
uniprot id: A3DMR3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

399550:SMAR RS02060
gene id: 399550:SMAR_RS02060
uniprot id: A3DLL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

399550:SMAR RS00940
gene id: 399550:SMAR_RS00940
uniprot id: A3DKZ0
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

399550:SMAR RS04330
gene id: 399550:SMAR_RS04330
uniprot id: A3DMT2
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

399550:SMAR RS02325
gene id: 399550:SMAR_RS02325
uniprot id: A3DLQ9
names: Similarity
messages: Belongs to the UPF0047 family.

399550:SMAR RS07530
gene id: 399550:SMAR_RS07530
uniprot id: A3DPH9
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

399550:SMAR RS04745
gene id: 399550:SMAR_RS04745
uniprot id: A3DN06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

399550:SMAR RS01190
gene id: 399550:SMAR_RS01190
uniprot id: A3DL40
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.
messages: Belongs to the Cren7 family.
messages: Cytoplasm
messages: Methylated at multiple sites, to varying extents.
messages: Monomer.

399550:SMAR RS07745
gene id: 399550:SMAR_RS07745
uniprot id: A3DPM1
names: Similarity
messages: Belongs to the peptidase U62 family.

399550:SMAR RS05980
gene id: 399550:SMAR_RS05980
uniprot id: A3DNN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

399550:SMAR RS03570
gene id: 399550:SMAR_RS03570
uniprot id: A3DME0
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

399550:SMAR RS04025
gene id: 399550:SMAR_RS04025
uniprot id: A3DMM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

399550:SMAR RS05770
gene id: 399550:SMAR_RS05770
uniprot id: A3DNJ8
names: Similarity
messages: Belongs to the GcvT family.

399550:SMAR RS04155
gene id: 399550:SMAR_RS04155
uniprot id: A3DMP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

399550:SMAR RS03145
gene id: 399550:SMAR_RS03145
uniprot id: A3DM63
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

399550:SMAR RS03240
gene id: 399550:SMAR_RS03240
uniprot id: A3DM80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

399550:SMAR RS01025
gene id: 399550:SMAR_RS01025
uniprot id: A3DL07
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

399550:SMAR RS05530
gene id: 399550:SMAR_RS05530
uniprot id: A3DNF6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

399550:SMAR RS02610
gene id: 399550:SMAR_RS02610
uniprot id: A3DLW5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

399550:SMAR RS05635
gene id: 399550:SMAR_RS05635
uniprot id: A3DNH4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

399550:SMAR RS02560
gene id: 399550:SMAR_RS02560
uniprot id: A3DLV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

399550:SMAR RS01675
gene id: 399550:SMAR_RS01675
uniprot id: A3DLD4
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.