39664:BKM01 RS03735
gene id: 39664:BKM01_RS03735
uniprot id: A0A2D3C916
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

39664:BKM01 RS04940
gene id: 39664:BKM01_RS04940
uniprot id: A0A2D3C630
names: Similarity
messages: Belongs to the UPF0210 family.

39664:BKM01 RS02155
gene id: 39664:BKM01_RS02155
uniprot id: A0A2D3C8X5
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

39664:BKM01 RS02375
gene id: 39664:BKM01_RS02375
uniprot id: A0A2D3C4V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

39664:BKM01 RS09310
gene id: 39664:BKM01_RS09310
uniprot id: A0A2D3C875
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

39664:BKM01 RS05645
gene id: 39664:BKM01_RS05645
uniprot id: A0A2D3C457
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

39664:BKM01 RS03645
gene id: 39664:BKM01_RS03645
uniprot id: A0A2D3C5E0
names: Function
messages: Protects DNA against thermal denaturation and modulates transcription.

39664:BKM01 RS01850
gene id: 39664:BKM01_RS01850
uniprot id: A0A2D3C3B9
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS07685
gene id: 39664:BKM01_RS07685
uniprot id: A0A2D3C9D2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

39664:BKM01 RS00730
gene id: 39664:BKM01_RS00730
uniprot id: A0A2D3C377
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS09640
gene id: 39664:BKM01_RS09640
uniprot id: A0A2D3C8G5
names: Subcellular Location Annotation
messages: Cell membrane

39664:BKM01 RS05825
gene id: 39664:BKM01_RS05825
uniprot id: A0A2D3C6I2
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

39664:BKM01 RS09285
gene id: 39664:BKM01_RS09285
uniprot id: A0A2D3C623
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.

39664:BKM01 RS00225
gene id: 39664:BKM01_RS00225
uniprot id: A0A2D3C358
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS03105
gene id: 39664:BKM01_RS03105
uniprot id: A0A2D3C565
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

39664:BKM01 RS05670
gene id: 39664:BKM01_RS05670
uniprot id: A0A2D3C6F6
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

39664:BKM01 RS07020
gene id: 39664:BKM01_RS07020
uniprot id: A0A2D3C749
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS08670
gene id: 39664:BKM01_RS08670
uniprot id: A0A2D3C7V3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

39664:BKM01 RS07730
gene id: 39664:BKM01_RS07730
uniprot id: A0A2D3C7H9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

39664:BKM01 RS09210
gene id: 39664:BKM01_RS09210
uniprot id: A0A2D3C873
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

39664:BKM01 RS02170
gene id: 39664:BKM01_RS02170
uniprot id: A0A2D3C4P7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

39664:BKM01 RS09395
gene id: 39664:BKM01_RS09395
uniprot id: A0A2D3C882
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS08115
gene id: 39664:BKM01_RS08115
uniprot id: A0A2D3C5I7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

39664:BKM01 RS01490
gene id: 39664:BKM01_RS01490
uniprot id: A0A2D3C906
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

39664:BKM01 RS05140
gene id: 39664:BKM01_RS05140
uniprot id: A0A2D3C3W6
names: Similarity
messages: Belongs to the HepT RNase toxin family.

39664:BKM01 RS10405
gene id: 39664:BKM01_RS10405
uniprot id: A0A2D3C8P7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

39664:BKM01 RS10400
gene id: 39664:BKM01_RS10400
uniprot id: A0A2D3C8T1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

39664:BKM01 RS01485
gene id: 39664:BKM01_RS01485
uniprot id: A0A2D3C4D0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

39664:BKM01 RS10655
gene id: 39664:BKM01_RS10655
uniprot id: A0A2D3C8U0
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS01650
gene id: 39664:BKM01_RS01650
uniprot id: A0A2D3C4G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

39664:BKM01 RS06455
gene id: 39664:BKM01_RS06455
uniprot id: A0A2D3C6T0
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

39664:BKM01 RS09975
gene id: 39664:BKM01_RS09975
uniprot id: A0A2D3C6E3
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

39664:BKM01 RS02725
gene id: 39664:BKM01_RS02725
uniprot id: A0A2D3C506
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

39664:BKM01 RS04050
gene id: 39664:BKM01_RS04050
uniprot id: A0A2D3C5L6
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS00315
gene id: 39664:BKM01_RS00315
uniprot id: A0A2D3C3R8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

39664:BKM01 RS05755
gene id: 39664:BKM01_RS05755
uniprot id: A0A2D3C6H4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

39664:BKM01 RS10390
gene id: 39664:BKM01_RS10390
uniprot id: A0A2D3C6M4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

39664:BKM01 RS09525
gene id: 39664:BKM01_RS09525
uniprot id: A0A2D3C8G4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

39664:BKM01 RS10320
gene id: 39664:BKM01_RS10320
uniprot id: A0A2D3C8R5
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS08650
gene id: 39664:BKM01_RS08650
uniprot id: A0A2D3C5S1
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS03925
gene id: 39664:BKM01_RS03925
uniprot id: A0A2D3C5M5
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy.

39664:BKM01 RS04700
gene id: 39664:BKM01_RS04700
uniprot id: A0A2D3C5X6
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

39664:BKM01 RS07145
gene id: 39664:BKM01_RS07145
uniprot id: A0A2D3C502
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

39664:BKM01 RS06970
gene id: 39664:BKM01_RS06970
uniprot id: A3QPW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

39664:BKM01 RS07160
gene id: 39664:BKM01_RS07160
uniprot id: A0A2D3C782
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

39664:BKM01 RS05160
gene id: 39664:BKM01_RS05160
uniprot id: A0A2D3C716
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

39664:BKM01 RS03840
gene id: 39664:BKM01_RS03840
uniprot id: A0A2D3C5J0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS01415
gene id: 39664:BKM01_RS01415
uniprot id: A0A2D3C4C1
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS03280
gene id: 39664:BKM01_RS03280
uniprot id: A0A2D3C597
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

39664:BKM01 RS10680
gene id: 39664:BKM01_RS10680
uniprot id: A0A2D3C8U7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

39664:BKM01 RS07785
gene id: 39664:BKM01_RS07785
uniprot id: A0A2D3C5C6
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

39664:BKM01 RS07290
gene id: 39664:BKM01_RS07290
uniprot id: A0A2D3C799
names: Similarity
messages: Belongs to the AAA ATPase family.

39664:BKM01 RS00110
gene id: 39664:BKM01_RS00110
uniprot id: A0A2D3C353
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS00545
gene id: 39664:BKM01_RS00545
uniprot id: A0A2D3C3W8
names: Similarity
messages: Belongs to the thioesterase PaaI family.

39664:BKM01 RS05830
gene id: 39664:BKM01_RS05830
uniprot id: A0A2D3C6I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

39664:BKM01 RS03305
gene id: 39664:BKM01_RS03305
uniprot id: A0A2D3C594
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

39664:BKM01 RS06245
gene id: 39664:BKM01_RS06245
uniprot id: A0A2D3C4G7
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS08545
gene id: 39664:BKM01_RS08545
uniprot id: A0A2D3C7T4
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

39664:BKM01 RS09400
gene id: 39664:BKM01_RS09400
uniprot id: A0A2D3C8C3
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS09765
gene id: 39664:BKM01_RS09765
uniprot id: A0A2D3C8I5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

39664:BKM01 RS03100
gene id: 39664:BKM01_RS03100
uniprot id: A0A2D3C569
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

39664:BKM01 RS06670
gene id: 39664:BKM01_RS06670
uniprot id: Q2KP09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

39664:BKM01 RS02830
gene id: 39664:BKM01_RS02830
uniprot id: A0A2D3C522
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

39664:BKM01 RS05765
gene id: 39664:BKM01_RS05765
uniprot id: A0A2D3C6I8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

39664:BKM01 RS07645
gene id: 39664:BKM01_RS07645
uniprot id: A0A2D3C7F8
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.
messages: Cytoplasm
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine.

39664:BKM01 RS10095
gene id: 39664:BKM01_RS10095
uniprot id: A0A2D3C6H5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS03015
gene id: 39664:BKM01_RS03015
uniprot id: A0A2D3C535
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

39664:BKM01 RS07255
gene id: 39664:BKM01_RS07255
uniprot id: A0A2D3C770
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

39664:BKM01 RS04670
gene id: 39664:BKM01_RS04670
uniprot id: A0A2D3C5X1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

39664:BKM01 RS02820
gene id: 39664:BKM01_RS02820
uniprot id: A0A2D3C519
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

39664:BKM01 RS05150
gene id: 39664:BKM01_RS05150
uniprot id: A0A2D3C656
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

39664:BKM01 RS08680
gene id: 39664:BKM01_RS08680
uniprot id: A0A2D3C812
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

39664:BKM01 RS09920
gene id: 39664:BKM01_RS09920
uniprot id: A0A2D3C6D4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS00050
gene id: 39664:BKM01_RS00050
uniprot id: A0A2D3C3M3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

39664:BKM01 RS07520
gene id: 39664:BKM01_RS07520
uniprot id: A0A2D3C7D8
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

39664:BKM01 RS08730
gene id: 39664:BKM01_RS08730
uniprot id: A0A2D3C801
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS05795
gene id: 39664:BKM01_RS05795
uniprot id: A0A2D3C6H7
names: Similarity
messages: Belongs to the AAA ATPase family.

39664:BKM01 RS04080
gene id: 39664:BKM01_RS04080
uniprot id: A0A2D3C5N1
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

39664:BKM01 RS08585
gene id: 39664:BKM01_RS08585
uniprot id: A0A2D3C7W7
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

39664:BKM01 RS10240
gene id: 39664:BKM01_RS10240
uniprot id: A0A2D3C8M2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

39664:BKM01 RS10125
gene id: 39664:BKM01_RS10125
uniprot id: A0A2D3C8L0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

39664:BKM01 RS07705
gene id: 39664:BKM01_RS07705
uniprot id: A0A2D3C7G7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

39664:BKM01 RS02360
gene id: 39664:BKM01_RS02360
uniprot id: A0A2D3C3D9
names: Cofactor
messages: Binds 2 irons ions per subunit via 4 cysteine residues per iron.

39664:BKM01 RS02960
gene id: 39664:BKM01_RS02960
uniprot id: A0A2D3C523
names: Similarity
messages: Belongs to the alpha-acetolactate decarboxylase family.

39664:BKM01 RS07625
gene id: 39664:BKM01_RS07625
uniprot id: A0A2D3C7E2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

39664:BKM01 RS00090
gene id: 39664:BKM01_RS00090
uniprot id: A0A2D3C3N4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

39664:BKM01 RS03155
gene id: 39664:BKM01_RS03155
uniprot id: A0A2D3C593
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

39664:BKM01 RS06485
gene id: 39664:BKM01_RS06485
uniprot id: A0A2D3C6V6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

39664:BKM01 RS03760
gene id: 39664:BKM01_RS03760
uniprot id: A0A2D3C5G0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

39664:BKM01 RS06430
gene id: 39664:BKM01_RS06430
uniprot id: A0A2D3C6U6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

39664:BKM01 RS05990
gene id: 39664:BKM01_RS05990
uniprot id: A0A2D3C6M2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

39664:BKM01 RS08855
gene id: 39664:BKM01_RS08855
uniprot id: A0A2D3C842
names: Similarity
messages: Belongs to the pyruvate kinase family.

39664:BKM01 RS02685
gene id: 39664:BKM01_RS02685
uniprot id: A0A2D3C4X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

39664:BKM01 RS02160
gene id: 39664:BKM01_RS02160
uniprot id: A0A2D3C4R4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

39664:BKM01 RS05660
gene id: 39664:BKM01_RS05660
uniprot id: A0A2D3C6G9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

39664:BKM01 RS09225
gene id: 39664:BKM01_RS09225
uniprot id: A0A2D3C878
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

39664:BKM01 RS07665
gene id: 39664:BKM01_RS07665
uniprot id: A0A2D3C7G6
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine.

39664:BKM01 RS07425
gene id: 39664:BKM01_RS07425
uniprot id: A0A2D3C7B5
names: Similarity
messages: Belongs to the citrate synthase family.

39664:BKM01 RS09475
gene id: 39664:BKM01_RS09475
uniprot id: A0A2D3C8B8
names: Similarity
messages: Belongs to the LarC family.

39664:BKM01 RS03190
gene id: 39664:BKM01_RS03190
uniprot id: A0A2D3C3H0
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

39664:BKM01 RS08005
gene id: 39664:BKM01_RS08005
uniprot id: A0A2D3C5F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

39664:BKM01 RS02710
gene id: 39664:BKM01_RS02710
uniprot id: A0A2D3C518
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

39664:BKM01 RS07470
gene id: 39664:BKM01_RS07470
uniprot id: A0A2D3C7A9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

39664:BKM01 RS03765
gene id: 39664:BKM01_RS03765
uniprot id: A0A2D3C5J1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

39664:BKM01 RS07490
gene id: 39664:BKM01_RS07490
uniprot id: A0A2D3C7D7
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

39664:BKM01 RS08740
gene id: 39664:BKM01_RS08740
uniprot id: A0A2D3C7Y1
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS02435
gene id: 39664:BKM01_RS02435
uniprot id: A0A2D3C4W7
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

39664:BKM01 RS09450
gene id: 39664:BKM01_RS09450
uniprot id: A0A2D3C889
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

39664:BKM01 RS03045
gene id: 39664:BKM01_RS03045
uniprot id: A0A2D3C574
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

39664:BKM01 RS08620
gene id: 39664:BKM01_RS08620
uniprot id: A0A2D3C802
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS06000
gene id: 39664:BKM01_RS06000
uniprot id: A0A2D3C6L9
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

39664:BKM01 RS03175
gene id: 39664:BKM01_RS03175
uniprot id: A0A2D3C570
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

39664:BKM01 RS09495
gene id: 39664:BKM01_RS09495
uniprot id: A0A2D3C671
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

39664:BKM01 RS04085
gene id: 39664:BKM01_RS04085
uniprot id: A0A2D3C5N6
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

39664:BKM01 RS08765
gene id: 39664:BKM01_RS08765
uniprot id: A0A2D3C5T3
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

39664:BKM01 RS05710
gene id: 39664:BKM01_RS05710
uniprot id: A0A2D3C6I0
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

39664:BKM01 RS03195
gene id: 39664:BKM01_RS03195
uniprot id: A0A2D3C3H1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

39664:BKM01 RS01955
gene id: 39664:BKM01_RS01955
uniprot id: A0A2D3C3C4
names: Cofactor
messages: Binds 1 zinc ion per subunit.

39664:BKM01 RS06405
gene id: 39664:BKM01_RS06405
uniprot id: A0A2D3C974
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS02975
gene id: 39664:BKM01_RS02975
uniprot id: A0A2D3C526
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

39664:BKM01 RS09530
gene id: 39664:BKM01_RS09530
uniprot id: A0A2D3C8B3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

39664:BKM01 RS09555
gene id: 39664:BKM01_RS09555
uniprot id: A0A2D3C681
names: Similarity
messages: Belongs to the ZPR1 family.

39664:BKM01 RS03180
gene id: 39664:BKM01_RS03180
uniprot id: A0A2D3C562
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

39664:BKM01 RS10365
gene id: 39664:BKM01_RS10365
uniprot id: A0A2D3C8R3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

39664:BKM01 RS02645
gene id: 39664:BKM01_RS02645
uniprot id: A0A2D3C3E8
names: Similarity
messages: Belongs to the Ahb/Nir family.

39664:BKM01 RS02835
gene id: 39664:BKM01_RS02835
uniprot id: A0A2D3C512
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homodimer.

39664:BKM01 RS04835
gene id: 39664:BKM01_RS04835
uniprot id: A0A2D3C602
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

39664:BKM01 RS00720
gene id: 39664:BKM01_RS00720
uniprot id: A0A2D3C3Z3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS01600
gene id: 39664:BKM01_RS01600
uniprot id: A0A2D3C4E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

39664:BKM01 RS00385
gene id: 39664:BKM01_RS00385
uniprot id: A0A2D3C3T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

39664:BKM01 RS08300
gene id: 39664:BKM01_RS08300
uniprot id: A0A2D3C976
names: Similarity
messages: Belongs to the TlyA family.

39664:BKM01 RS04680
gene id: 39664:BKM01_RS04680
uniprot id: A0A2D3C5Y1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

39664:BKM01 RS01595
gene id: 39664:BKM01_RS01595
uniprot id: A0A2D3C4F7
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

39664:BKM01 RS04195
gene id: 39664:BKM01_RS04195
uniprot id: A0A2D3C5Q7
names: Cofactor
names: Similarity
messages: Belongs to the RimK family.
messages: Binds 2 magnesium or manganese ions per subunit.

39664:BKM01 RS00010
gene id: 39664:BKM01_RS00010
uniprot id: A0A2D3C344
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

39664:BKM01 RS10225
gene id: 39664:BKM01_RS10225
uniprot id: A0A2D3C8T9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

39664:BKM01 RS06390
gene id: 39664:BKM01_RS06390
uniprot id: A0A2D3C6T2
names: Similarity
messages: Belongs to the AAA ATPase family.

39664:BKM01 RS01940
gene id: 39664:BKM01_RS01940
uniprot id: A0A2D3C4K7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

39664:BKM01 RS06800
gene id: 39664:BKM01_RS06800
uniprot id: A0A2D3C704
names: Similarity
messages: Belongs to the oxoprolinase family.

39664:BKM01 RS01340
gene id: 39664:BKM01_RS01340
uniprot id: A0A2D3C499
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

39664:BKM01 RS07780
gene id: 39664:BKM01_RS07780
uniprot id: A0A2D3C7H8
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

39664:BKM01 RS01765
gene id: 39664:BKM01_RS01765
uniprot id: A0A2D3C4J4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

39664:BKM01 RS03665
gene id: 39664:BKM01_RS03665
uniprot id: A0A2D3C5F4
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

39664:BKM01 RS04685
gene id: 39664:BKM01_RS04685
uniprot id: A0A2D3C5Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

39664:BKM01 RS09330
gene id: 39664:BKM01_RS09330
uniprot id: A0A2D3C637
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.

39664:BKM01 RS09485
gene id: 39664:BKM01_RS09485
uniprot id: A0A2D3C8C1
names: Function
messages: Probably involved in the biogenesis of the ribosome.

39664:BKM01 RS04230
gene id: 39664:BKM01_RS04230
uniprot id: A0A2D3C5P9
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

39664:BKM01 RS08310
gene id: 39664:BKM01_RS08310
uniprot id: A0A2D3C7Q1
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

39664:BKM01 RS10135
gene id: 39664:BKM01_RS10135
uniprot id: A0A2D3C8K1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

39664:BKM01 RS08785
gene id: 39664:BKM01_RS08785
uniprot id: A0A2D3C811
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

39664:BKM01 RS04040
gene id: 39664:BKM01_RS04040
uniprot id: A0A2D3C5M2
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS07000
gene id: 39664:BKM01_RS07000
uniprot id: A0A2D3C724
names: Similarity
messages: Belongs to the MtxX family.

39664:BKM01 RS02535
gene id: 39664:BKM01_RS02535
uniprot id: A0A2D3C4Y6
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

39664:BKM01 RS02230
gene id: 39664:BKM01_RS02230
uniprot id: A0A2D3C4Q6
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

39664:BKM01 RS01635
gene id: 39664:BKM01_RS01635
uniprot id: A0A2D3C4E4
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

39664:BKM01 RS10430
gene id: 39664:BKM01_RS10430
uniprot id: A0A2D3C8Q2
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS06045
gene id: 39664:BKM01_RS06045
uniprot id: A0A2D3C6K6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

39664:BKM01 RS07150
gene id: 39664:BKM01_RS07150
uniprot id: A0A2D3C500
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

39664:BKM01 RS06160
gene id: 39664:BKM01_RS06160
uniprot id: A0A2D3C6Q3
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

39664:BKM01 RS08160
gene id: 39664:BKM01_RS08160
uniprot id: A0A2D3C7P9
names: Similarity
messages: Belongs to the AAA ATPase family.

39664:BKM01 RS01195
gene id: 39664:BKM01_RS01195
uniprot id: A0A2D3C393
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS06990
gene id: 39664:BKM01_RS06990
uniprot id: A0A2D3C751
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Cytoplasm

39664:BKM01 RS10280
gene id: 39664:BKM01_RS10280
uniprot id: A0A2D3C8N8
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

39664:BKM01 RS00575
gene id: 39664:BKM01_RS00575
uniprot id: A0A2D3C8X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

39664:BKM01 RS03120
gene id: 39664:BKM01_RS03120
uniprot id: A5JHC9
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

39664:BKM01 RS05395
gene id: 39664:BKM01_RS05395
uniprot id: A0A2D3C6A0
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

39664:BKM01 RS06835
gene id: 39664:BKM01_RS06835
uniprot id: A0A2D3C719
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

39664:BKM01 RS03970
gene id: 39664:BKM01_RS03970
uniprot id: A0A2D3C5J9
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

39664:BKM01 RS07480
gene id: 39664:BKM01_RS07480
uniprot id: A0A2D3C576
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

39664:BKM01 RS04235
gene id: 39664:BKM01_RS04235
uniprot id: A0A2D3C5T6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

39664:BKM01 RS07845
gene id: 39664:BKM01_RS07845
uniprot id: A0A2D3C5C9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

39664:BKM01 RS09925
gene id: 39664:BKM01_RS09925
uniprot id: A0A2D3C8J7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS08555
gene id: 39664:BKM01_RS08555
uniprot id: A0A2D3C9F2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

39664:BKM01 RS09105
gene id: 39664:BKM01_RS09105
uniprot id: A0A2D3C852
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

39664:BKM01 RS02580
gene id: 39664:BKM01_RS02580
uniprot id: A0A2D3C4V7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily.
messages: Binds 1 Zn(2+) ion per subunit. This ion is coordinated with 2 cysteines, 1 glutamate and a water molecule that dissociates from the zinc ion to allow the coordination of the amino group of the serine substrate, which is essential for catalysis.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is presumably involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer.

39664:BKM01 RS01330
gene id: 39664:BKM01_RS01330
uniprot id: A0A2D3C4A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

39664:BKM01 RS07140
gene id: 39664:BKM01_RS07140
uniprot id: A0A2D3C767
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

39664:BKM01 RS09190
gene id: 39664:BKM01_RS09190
uniprot id: A0A2D3C8A2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

39664:BKM01 RS02215
gene id: 39664:BKM01_RS02215
uniprot id: A0A2D3C4S1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

39664:BKM01 RS02510
gene id: 39664:BKM01_RS02510
uniprot id: A0A2D3C4V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

39664:BKM01 RS06995
gene id: 39664:BKM01_RS06995
uniprot id: A0A2D3C753
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

39664:BKM01 RS00670
gene id: 39664:BKM01_RS00670
uniprot id: A0A2D3C3Y3
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS06040
gene id: 39664:BKM01_RS06040
uniprot id: A0A2D3C6N3
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

39664:BKM01 RS05580
gene id: 39664:BKM01_RS05580
uniprot id: A0A2D3C6C3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

39664:BKM01 RS10475
gene id: 39664:BKM01_RS10475
uniprot id: A0A2D3C8R6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

39664:BKM01 RS05865
gene id: 39664:BKM01_RS05865
uniprot id: A0A2D3C495
names: Similarity
messages: Belongs to the UPF0235 family.

39664:BKM01 RS09665
gene id: 39664:BKM01_RS09665
uniprot id: A0A2D3C8F1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

39664:BKM01 RS06240
gene id: 39664:BKM01_RS06240
uniprot id: A0A2D3C4G8
names: Similarity
messages: Belongs to the DtxR/MntR family.

39664:BKM01 RS06200
gene id: 39664:BKM01_RS06200
uniprot id: A0A2D3C6Q8
names: Domain
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.
messages: Involved in DNA damage repair.

39664:BKM01 RS09580
gene id: 39664:BKM01_RS09580
uniprot id: A0A2D3C8H4
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

39664:BKM01 RS03865
gene id: 39664:BKM01_RS03865
uniprot id: A0A2D3C3J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

39664:BKM01 RS06150
gene id: 39664:BKM01_RS06150
uniprot id: A0A2D3C6Q4
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

39664:BKM01 RS06550
gene id: 39664:BKM01_RS06550
uniprot id: A0A2D3C6U8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

39664:BKM01 RS06755
gene id: 39664:BKM01_RS06755
uniprot id: A0A2D3C711
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

39664:BKM01 RS03365
gene id: 39664:BKM01_RS03365
uniprot id: A0A2D3C5A2
names: Similarity
messages: Belongs to the class-I fumarase family.

39664:BKM01 RS10420
gene id: 39664:BKM01_RS10420
uniprot id: A0A2D3C8Q4
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

39664:BKM01 RS03720
gene id: 39664:BKM01_RS03720
uniprot id: A0A2D3C5G6
names: Similarity
messages: Belongs to the PDCD5 family.

39664:BKM01 RS07720
gene id: 39664:BKM01_RS07720
uniprot id: A0A2D3C5B7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

39664:BKM01 RS10455
gene id: 39664:BKM01_RS10455
uniprot id: A0A2D3C8U2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

39664:BKM01 RS01155
gene id: 39664:BKM01_RS01155
uniprot id: A0A2D3C472
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

39664:BKM01 RS08285
gene id: 39664:BKM01_RS08285
uniprot id: A0A2D3C5L5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

39664:BKM01 RS00745
gene id: 39664:BKM01_RS00745
uniprot id: A0A2D3C3Z6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

39664:BKM01 RS07710
gene id: 39664:BKM01_RS07710
uniprot id: A0A2D3C7F1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

39664:BKM01 RS00405
gene id: 39664:BKM01_RS00405
uniprot id: A0A2D3C364
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

39664:BKM01 RS09655
gene id: 39664:BKM01_RS09655
uniprot id: A0A2D3C8E8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

39664:BKM01 RS05760
gene id: 39664:BKM01_RS05760
uniprot id: A0A2D3C937
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

39664:BKM01 RS00560
gene id: 39664:BKM01_RS00560
uniprot id: A0A2D3C3W4
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

39664:BKM01 RS06195
gene id: 39664:BKM01_RS06195
uniprot id: A0A2D3C4F5
names: Similarity
messages: Belongs to the SAICAR synthetase family.

39664:BKM01 RS06420
gene id: 39664:BKM01_RS06420
uniprot id: A0A2D3C948
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

39664:BKM01 RS10500
gene id: 39664:BKM01_RS10500
uniprot id: A0A2D3C6P6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

39664:BKM01 RS01130
gene id: 39664:BKM01_RS01130
uniprot id: A0A2D3C392
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

39664:BKM01 RS00760
gene id: 39664:BKM01_RS00760
uniprot id: A0A2D3C403
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

39664:BKM01 RS10145
gene id: 39664:BKM01_RS10145
uniprot id: A0A2D3C6I4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

39664:BKM01 RS00300
gene id: 39664:BKM01_RS00300
uniprot id: A0A2D3C3S0
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

39664:BKM01 RS10055
gene id: 39664:BKM01_RS10055
uniprot id: A0A2D3C8L7
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

39664:BKM01 RS07605
gene id: 39664:BKM01_RS07605
uniprot id: A0A2D3C7F9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS08050
gene id: 39664:BKM01_RS08050
uniprot id: A0A2D3C7N1
names: Similarity
messages: Belongs to the UPF0047 family.

39664:BKM01 RS03130
gene id: 39664:BKM01_RS03130
uniprot id: A0A2D3C552
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

39664:BKM01 RS00975
gene id: 39664:BKM01_RS00975
uniprot id: A0A2D3C429
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

39664:BKM01 RS08105
gene id: 39664:BKM01_RS08105
uniprot id: A0A2D3C7L8
names: Similarity
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.

39664:BKM01 RS09880
gene id: 39664:BKM01_RS09880
uniprot id: A0A2D3C8G1
names: Similarity
messages: Belongs to the UPF0285 family.

39664:BKM01 RS09545
gene id: 39664:BKM01_RS09545
uniprot id: A0A2D3C8C9
names: Similarity
messages: Belongs to the UPF0284 family.

39664:BKM01 RS03975
gene id: 39664:BKM01_RS03975
uniprot id: A0A2D3C5N5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS03900
gene id: 39664:BKM01_RS03900
uniprot id: A0A2D3C5I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

39664:BKM01 RS06475
gene id: 39664:BKM01_RS06475
uniprot id: A0A2D3C6V4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

39664:BKM01 RS05560
gene id: 39664:BKM01_RS05560
uniprot id: A0A2D3C6D1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS03750
gene id: 39664:BKM01_RS03750
uniprot id: A0A2D3C3I8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

39664:BKM01 RS00280
gene id: 39664:BKM01_RS00280
uniprot id: A0A2D3C360
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.
messages: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base.
messages: Monomer and homodimer.

39664:BKM01 RS03740
gene id: 39664:BKM01_RS03740
uniprot id: A0A2D3C5F1
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

39664:BKM01 RS03360
gene id: 39664:BKM01_RS03360
uniprot id: A0A2D3C5B1
names: Similarity
messages: Belongs to the class-I fumarase family.

39664:BKM01 RS03140
gene id: 39664:BKM01_RS03140
uniprot id: A0A2D3C3G8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

39664:BKM01 RS03205
gene id: 39664:BKM01_RS03205
uniprot id: A0A2D3C5A3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

39664:BKM01 RS10440
gene id: 39664:BKM01_RS10440
uniprot id: A0A2D3C6N4
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS10000
gene id: 39664:BKM01_RS10000
uniprot id: A0A2D3C8J1
names: Subcellular Location Annotation
messages: Cell membrane

39664:BKM01 RS09750
gene id: 39664:BKM01_RS09750
uniprot id: A0A2D3C6A4
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS06060
gene id: 39664:BKM01_RS06060
uniprot id: A0A2D3C6L1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS03135
gene id: 39664:BKM01_RS03135
uniprot id: A0A2D3C3G7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

39664:BKM01 RS07420
gene id: 39664:BKM01_RS07420
uniprot id: A0A2D3C7A0
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

39664:BKM01 RS07010
gene id: 39664:BKM01_RS07010
uniprot id: A0A2D3C747
names: Similarity
messages: Belongs to the MtrH family.

39664:BKM01 RS07225
gene id: 39664:BKM01_RS07225
uniprot id: A0A2D3C792
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

39664:BKM01 RS06945
gene id: 39664:BKM01_RS06945
uniprot id: A0A2D3C743
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

39664:BKM01 RS08290
gene id: 39664:BKM01_RS08290
uniprot id: A0A2D3C9A6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane

39664:BKM01 RS06220
gene id: 39664:BKM01_RS06220
uniprot id: A0A2D3C6N5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

39664:BKM01 RS07610
gene id: 39664:BKM01_RS07610
uniprot id: A0A2D3C7F7
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

39664:BKM01 RS08760
gene id: 39664:BKM01_RS08760
uniprot id: A0A2D3C5T9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

39664:BKM01 RS03650
gene id: 39664:BKM01_RS03650
uniprot id: A0A2D3C5H1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

39664:BKM01 RS02635
gene id: 39664:BKM01_RS02635
uniprot id: A0A2D3C4W1
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

39664:BKM01 RS00295
gene id: 39664:BKM01_RS00295
uniprot id: A0A2D3C3S1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS05985
gene id: 39664:BKM01_RS05985
uniprot id: A0A2D3C6L3
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

39664:BKM01 RS09915
gene id: 39664:BKM01_RS09915
uniprot id: A0A2D3C6E1
names: Function
names: Similarity
messages: Belongs to the dCTP deaminase family. Archaeal dUTPase subfamily.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

39664:BKM01 RS09510
gene id: 39664:BKM01_RS09510
uniprot id: A0A2D3C8C7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

39664:BKM01 RS06925
gene id: 39664:BKM01_RS06925
uniprot id: A0A2D3C4V4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

39664:BKM01 RS02650
gene id: 39664:BKM01_RS02650
uniprot id: A0A2D3C4X1
names: Similarity
messages: Belongs to the Ahb/Nir family.

39664:BKM01 RS01305
gene id: 39664:BKM01_RS01305
uniprot id: A0A2D3C398
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

39664:BKM01 RS05700
gene id: 39664:BKM01_RS05700
uniprot id: A0A2D3C470
names: Similarity
messages: Belongs to the peptidase S49 family.

39664:BKM01 RS08520
gene id: 39664:BKM01_RS08520
uniprot id: A0A2D3C7S3
names: Similarity
messages: Belongs to the UPF0145 family.

39664:BKM01 RS02450
gene id: 39664:BKM01_RS02450
uniprot id: A0A2D3C4V5
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

39664:BKM01 RS03210
gene id: 39664:BKM01_RS03210
uniprot id: A0A2D3C963
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS03530
gene id: 39664:BKM01_RS03530
uniprot id: A0A2D3C5D3
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

39664:BKM01 RS00115
gene id: 39664:BKM01_RS00115
uniprot id: A0A2D3C3M6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS09120
gene id: 39664:BKM01_RS09120
uniprot id: A0A2D3C858
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

39664:BKM01 RS05695
gene id: 39664:BKM01_RS05695
uniprot id: A0A2D3C469
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

39664:BKM01 RS02870
gene id: 39664:BKM01_RS02870
uniprot id: A0A2D3C548
names: Similarity
messages: Belongs to the UPF0179 family.

39664:BKM01 RS03690
gene id: 39664:BKM01_RS03690
uniprot id: A0A2D3C3I7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

39664:BKM01 RS02485
gene id: 39664:BKM01_RS02485
uniprot id: A0A2D3C4X6
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

39664:BKM01 RS03295
gene id: 39664:BKM01_RS03295
uniprot id: A0A2D3C5A0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

39664:BKM01 RS02525
gene id: 39664:BKM01_RS02525
uniprot id: A0A2D3C3E4
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

39664:BKM01 RS03755
gene id: 39664:BKM01_RS03755
uniprot id: A0A2D3C3I9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

39664:BKM01 RS08330
gene id: 39664:BKM01_RS08330
uniprot id: A0A2D3C7R4
names: Similarity
messages: Belongs to the UPF0212 family.

39664:BKM01 RS01770
gene id: 39664:BKM01_RS01770
uniprot id: A0A2D3C4I7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

39664:BKM01 RS07795
gene id: 39664:BKM01_RS07795
uniprot id: A0A2D3C7I9
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

39664:BKM01 RS07690
gene id: 39664:BKM01_RS07690
uniprot id: A0A2D3C9D1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

39664:BKM01 RS03785
gene id: 39664:BKM01_RS03785
uniprot id: A0A2D3C5H9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

39664:BKM01 RS06950
gene id: 39664:BKM01_RS06950
uniprot id: A0A2D3C717
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

39664:BKM01 RS05390
gene id: 39664:BKM01_RS05390
uniprot id: A0A2D3C6C5
names: Similarity
messages: Belongs to the PAPS reductase family. CysD subfamily.

39664:BKM01 RS02705
gene id: 39664:BKM01_RS02705
uniprot id: A0A2D3C4Y0
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

39664:BKM01 RS03495
gene id: 39664:BKM01_RS03495
uniprot id: A0A2D3C6W9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

39664:BKM01 RS04030
gene id: 39664:BKM01_RS04030
uniprot id: A0A2D3C5M1
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

39664:BKM01 RS09745
gene id: 39664:BKM01_RS09745
uniprot id: A0A2D3C6B1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

39664:BKM01 RS08155
gene id: 39664:BKM01_RS08155
uniprot id: A0A2D3C7M5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

39664:BKM01 RS03115
gene id: 39664:BKM01_RS03115
uniprot id: A0A2D3C561
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

39664:BKM01 RS05910
gene id: 39664:BKM01_RS05910
uniprot id: A0A2D3C4B3
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

39664:BKM01 RS01275
gene id: 39664:BKM01_RS01275
uniprot id: A0A2D3C492
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

39664:BKM01 RS07700
gene id: 39664:BKM01_RS07700
uniprot id: A0A2D3C7E9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

39664:BKM01 RS07530
gene id: 39664:BKM01_RS07530
uniprot id: A0A2D3C588
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS07555
gene id: 39664:BKM01_RS07555
uniprot id: A0A2D3C7F4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

39664:BKM01 RS03540
gene id: 39664:BKM01_RS03540
uniprot id: A0A2D3C5D6
names: Similarity
messages: Belongs to the peptidase C56 family.

39664:BKM01 RS05750
gene id: 39664:BKM01_RS05750
uniprot id: A0A2D3C476
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

39664:BKM01 RS04675
gene id: 39664:BKM01_RS04675
uniprot id: A0A2D3C605
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

39664:BKM01 RS08230
gene id: 39664:BKM01_RS08230
uniprot id: A0A2D3C7S6
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

39664:BKM01 RS05525
gene id: 39664:BKM01_RS05525
uniprot id: A0A2D3C6B2
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

39664:BKM01 RS02080
gene id: 39664:BKM01_RS02080
uniprot id: A0A2D3C4P9
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

39664:BKM01 RS02810
gene id: 39664:BKM01_RS02810
uniprot id: A0A2D3C4Z4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

39664:BKM01 RS10685
gene id: 39664:BKM01_RS10685
uniprot id: A0A2D3C912
names: Similarity
messages: Belongs to the peptidase M24B family.

39664:BKM01 RS06445
gene id: 39664:BKM01_RS06445
uniprot id: A0A2D3C985
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

39664:BKM01 RS02445
gene id: 39664:BKM01_RS02445
uniprot id: A0A2D3C4W2
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

39664:BKM01 RS08130
gene id: 39664:BKM01_RS08130
uniprot id: A0A2D3C7N2
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

39664:BKM01 RS00910
gene id: 39664:BKM01_RS00910
uniprot id: A0A2D3C382
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

39664:BKM01 RS09740
gene id: 39664:BKM01_RS09740
uniprot id: A0A2D3C8G2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

39664:BKM01 RS00045
gene id: 39664:BKM01_RS00045
uniprot id: A0A2D3C3L9
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

39664:BKM01 RS03355
gene id: 39664:BKM01_RS03355
uniprot id: A0A2D3C5A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

39664:BKM01 RS10205
gene id: 39664:BKM01_RS10205
uniprot id: A0A2D3C8Q1
names: Similarity
messages: Belongs to the HisA/HisF family.

39664:BKM01 RS03860
gene id: 39664:BKM01_RS03860
uniprot id: A0A2D3C3J2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

39664:BKM01 RS07400
gene id: 39664:BKM01_RS07400
uniprot id: A0A2D3C7B8
names: Similarity
messages: Belongs to the peptidase C56 family.

39664:BKM01 RS02575
gene id: 39664:BKM01_RS02575
uniprot id: A0A2D3C4W3
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

39664:BKM01 RS03395
gene id: 39664:BKM01_RS03395
uniprot id: A0A2D3C8Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

39664:BKM01 RS07075
gene id: 39664:BKM01_RS07075
uniprot id: A0A2D3C969
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

39664:BKM01 RS10210
gene id: 39664:BKM01_RS10210
uniprot id: A0A2D3C8L9
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

39664:BKM01 RS07230
gene id: 39664:BKM01_RS07230
uniprot id: A0A2D3C790
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.
messages: Belongs to the archease family.

39664:BKM01 RS09430
gene id: 39664:BKM01_RS09430
uniprot id: A0A2D3C8B0
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

39664:BKM01 RS04980
gene id: 39664:BKM01_RS04980
uniprot id: A0A2D3C631
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

39664:BKM01 RS02590
gene id: 39664:BKM01_RS02590
uniprot id: A0A2D3C3E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

39664:BKM01 RS07910
gene id: 39664:BKM01_RS07910
uniprot id: A0A2D3C7J7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

39664:BKM01 RS03400
gene id: 39664:BKM01_RS03400
uniprot id: A0A2D3C5D2
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

39664:BKM01 RS01550
gene id: 39664:BKM01_RS01550
uniprot id: A0A2D3C4E2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

39664:BKM01 RS09115
gene id: 39664:BKM01_RS09115
uniprot id: A0A2D3C5Z4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

39664:BKM01 RS07925
gene id: 39664:BKM01_RS07925
uniprot id: A0A2D3C7J2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

39664:BKM01 RS02935
gene id: 39664:BKM01_RS02935
uniprot id: A0A2D3C540
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

39664:BKM01 RS03200
gene id: 39664:BKM01_RS03200
uniprot id: A0A2D3C567
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

39664:BKM01 RS04160
gene id: 39664:BKM01_RS04160
uniprot id: A0A2D3C5N9
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

39664:BKM01 RS01725
gene id: 39664:BKM01_RS01725
uniprot id: A0A2D3C4H1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

39664:BKM01 RS08690
gene id: 39664:BKM01_RS08690
uniprot id: A0A2D3C7X0
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

39664:BKM01 RS05405
gene id: 39664:BKM01_RS05405
uniprot id: A0A2D3C6A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.
messages: Membrane

39664:BKM01 RS03700
gene id: 39664:BKM01_RS03700
uniprot id: A0A2D3C5I2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

39664:BKM01 RS00905
gene id: 39664:BKM01_RS00905
uniprot id: A0A2D3C383
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

39664:BKM01 RS00075
gene id: 39664:BKM01_RS00075
uniprot id: A0A2D3C3M7
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

39664:BKM01 RS09520
gene id: 39664:BKM01_RS09520
uniprot id: A0A2D3C8E5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

39664:BKM01 RS07640
gene id: 39664:BKM01_RS07640
uniprot id: A0A2D3C7E1
names: Similarity
messages: Belongs to the AdoMet synthase family.

39664:BKM01 RS10270
gene id: 39664:BKM01_RS10270
uniprot id: A0A2D3C8S6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

39664:BKM01 RS07485
gene id: 39664:BKM01_RS07485
uniprot id: A0A2D3C568
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

39664:BKM01 RS10150
gene id: 39664:BKM01_RS10150
uniprot id: A0A2D3C6G8
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

39664:BKM01 RS08015
gene id: 39664:BKM01_RS08015
uniprot id: A0A2D3C7L9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

39664:BKM01 RS00470
gene id: 39664:BKM01_RS00470
uniprot id: A0A2D3C3T7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

39664:BKM01 RS01065
gene id: 39664:BKM01_RS01065
uniprot id: A0A2D3C455
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

39664:BKM01 RS08525
gene id: 39664:BKM01_RS08525
uniprot id: A0A2D3C7V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

39664:BKM01 RS06005
gene id: 39664:BKM01_RS06005
uniprot id: A0A2D3C6K3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

39664:BKM01 RS03930
gene id: 39664:BKM01_RS03930
uniprot id: A0A2D3C5K1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhD family.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. Probably maintains the overall quaternary structure of the ACDS complex.

39664:BKM01 RS09090
gene id: 39664:BKM01_RS09090
uniprot id: A0A2D3C848
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS01605
gene id: 39664:BKM01_RS01605
uniprot id: A0A2D3C4F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

39664:BKM01 RS03275
gene id: 39664:BKM01_RS03275
uniprot id: A0A2D3C5B4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

39664:BKM01 RS07045
gene id: 39664:BKM01_RS07045
uniprot id: A0A2D3C757
names: Similarity
messages: Belongs to the DNA photolyase class-2 family.

39664:BKM01 RS05735
gene id: 39664:BKM01_RS05735
uniprot id: A0A2D3C6F1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

39664:BKM01 RS01505
gene id: 39664:BKM01_RS01505
uniprot id: A0A2D3C4D7
names: Similarity
messages: Belongs to the FBPase class 2 family.

39664:BKM01 RS09565
gene id: 39664:BKM01_RS09565
uniprot id: A0A2D3C8D6
names: Subcellular Location Annotation
messages: Cytoplasm

39664:BKM01 RS01470
gene id: 39664:BKM01_RS01470
uniprot id: A0A2D3C4D2
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS06650
gene id: 39664:BKM01_RS06650
uniprot id: A0A2D3C6Z3
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

39664:BKM01 RS07260
gene id: 39664:BKM01_RS07260
uniprot id: A0A2D3C785
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

39664:BKM01 RS03555
gene id: 39664:BKM01_RS03555
uniprot id: A0A2D3C5C4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

39664:BKM01 RS05145
gene id: 39664:BKM01_RS05145
uniprot id: A0A2D3C3X7
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

39664:BKM01 RS09045
gene id: 39664:BKM01_RS09045
uniprot id: A0A2D3C814
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

39664:BKM01 RS01515
gene id: 39664:BKM01_RS01515
uniprot id: A0A2D3C3A6
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS01205
gene id: 39664:BKM01_RS01205
uniprot id: A0A2D3C481
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

39664:BKM01 RS08645
gene id: 39664:BKM01_RS08645
uniprot id: A0A2D3C7X7
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS08120
gene id: 39664:BKM01_RS08120
uniprot id: A0A2D3C5H3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

39664:BKM01 RS09220
gene id: 39664:BKM01_RS09220
uniprot id: A0A2D3C613
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

39664:BKM01 RS06890
gene id: 39664:BKM01_RS06890
uniprot id: A0A2D3C733
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS03165
gene id: 39664:BKM01_RS03165
uniprot id: A0A2D3C575
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

39664:BKM01 RS01365
gene id: 39664:BKM01_RS01365
uniprot id: A0A2D3C4B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

39664:BKM01 RS03745
gene id: 39664:BKM01_RS03745
uniprot id: A0A2D3C5F5
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

39664:BKM01 RS02930
gene id: 39664:BKM01_RS02930
uniprot id: A0A2D3C538
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

39664:BKM01 RS08135
gene id: 39664:BKM01_RS08135
uniprot id: A0A2D3C7P7
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

39664:BKM01 RS03470
gene id: 39664:BKM01_RS03470
uniprot id: A0A2D3C5C8
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

39664:BKM01 RS06110
gene id: 39664:BKM01_RS06110
uniprot id: A0A2D3C6L7
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

39664:BKM01 RS02200
gene id: 39664:BKM01_RS02200
uniprot id: A0A2D3C4P3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

39664:BKM01 RS03170
gene id: 39664:BKM01_RS03170
uniprot id: A0A2D3C580
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

39664:BKM01 RS06545
gene id: 39664:BKM01_RS06545
uniprot id: A0A2D3C6X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

39664:BKM01 RS02915
gene id: 39664:BKM01_RS02915
uniprot id: A0A2D3C3F8
names: Similarity
messages: Belongs to the monomethylamine methyltransferase family.

39664:BKM01 RS06725
gene id: 39664:BKM01_RS06725
uniprot id: A0A2D3C700
names: Similarity
messages: Belongs to the UPF0200 family.

39664:BKM01 RS07575
gene id: 39664:BKM01_RS07575
uniprot id: A0A2D3C7E7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

39664:BKM01 RS06740
gene id: 39664:BKM01_RS06740
uniprot id: A0A2D3C4S9
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

39664:BKM01 RS07565
gene id: 39664:BKM01_RS07565
uniprot id: A0A2D3C7D2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.

39664:BKM01 RS05490
gene id: 39664:BKM01_RS05490
uniprot id: A0A2D3C430
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

39664:BKM01 RS09610
gene id: 39664:BKM01_RS09610
uniprot id: A0A2D3C8E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

39664:BKM01 RS01160
gene id: 39664:BKM01_RS01160
uniprot id: A0A2D3C473
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

39664:BKM01 RS01220
gene id: 39664:BKM01_RS01220
uniprot id: A0A2D3C483
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS01290
gene id: 39664:BKM01_RS01290
uniprot id: A0A2D3C489
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

39664:BKM01 RS07310
gene id: 39664:BKM01_RS07310
uniprot id: A0A2D3C781
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

39664:BKM01 RS01125
gene id: 39664:BKM01_RS01125
uniprot id: A0A2D3C463
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

39664:BKM01 RS01320
gene id: 39664:BKM01_RS01320
uniprot id: A0A2D3C4A4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

39664:BKM01 RS02240
gene id: 39664:BKM01_RS02240
uniprot id: A0A2D3C3D5
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

39664:BKM01 RS05200
gene id: 39664:BKM01_RS05200
uniprot id: A0A2D3C3Y7
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS03405
gene id: 39664:BKM01_RS03405
uniprot id: A0A2D3C5B5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

39664:BKM01 RS00440
gene id: 39664:BKM01_RS00440
uniprot id: A0A2D3C3U6
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

39664:BKM01 RS00360
gene id: 39664:BKM01_RS00360
uniprot id: A0A2D3C3T0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS02615
gene id: 39664:BKM01_RS02615
uniprot id: A0A2D3C4Y7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS01230
gene id: 39664:BKM01_RS01230
uniprot id: A0A2D3C479
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

39664:BKM01 RS01930
gene id: 39664:BKM01_RS01930
uniprot id: A0A2D3C4L5
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS09445
gene id: 39664:BKM01_RS09445
uniprot id: A0A2D3C8B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

39664:BKM01 RS07835
gene id: 39664:BKM01_RS07835
uniprot id: A0A2D3C7I8
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

39664:BKM01 RS02135
gene id: 39664:BKM01_RS02135
uniprot id: A0A2D3C3D0
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

39664:BKM01 RS00060
gene id: 39664:BKM01_RS00060
uniprot id: A0A2D3C349
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS02785
gene id: 39664:BKM01_RS02785
uniprot id: A0A2D3C504
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

39664:BKM01 RS04740
gene id: 39664:BKM01_RS04740
uniprot id: A0A2D3C5Z1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

39664:BKM01 RS04695
gene id: 39664:BKM01_RS04695
uniprot id: A0A2D3C5Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

39664:BKM01 RS07815
gene id: 39664:BKM01_RS07815
uniprot id: A0A2D3C7H1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

39664:BKM01 RS07725
gene id: 39664:BKM01_RS07725
uniprot id: A0A2D3C5A9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

39664:BKM01 RS03450
gene id: 39664:BKM01_RS03450
uniprot id: A0A2D3C5A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane

39664:BKM01 RS06070
gene id: 39664:BKM01_RS06070
uniprot id: A0A2D3C4E3
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

39664:BKM01 RS01345
gene id: 39664:BKM01_RS01345
uniprot id: A0A2D3C4A7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The Rnf complex is probably composed of eight subunits, including RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

39664:BKM01 RS08000
gene id: 39664:BKM01_RS08000
uniprot id: A0A2D3C5G7
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

39664:BKM01 RS00850
gene id: 39664:BKM01_RS00850
uniprot id: A0A2D3C380
names: Similarity
messages: Belongs to the glutamate synthase family.

39664:BKM01 RS04105
gene id: 39664:BKM01_RS04105
uniprot id: A0A2D3C5M7
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

39664:BKM01 RS06080
gene id: 39664:BKM01_RS06080
uniprot id: A0A2D3C6N6
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

39664:BKM01 RS10510
gene id: 39664:BKM01_RS10510
uniprot id: A0A2D3C8V1
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

39664:BKM01 RS03550
gene id: 39664:BKM01_RS03550
uniprot id: A0A2D3C5C1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

39664:BKM01 RS06505
gene id: 39664:BKM01_RS06505
uniprot id: A0A2D3C6V7
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

39664:BKM01 RS10635
gene id: 39664:BKM01_RS10635
uniprot id: A0A2D3C8Z8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

39664:BKM01 RS03880
gene id: 39664:BKM01_RS03880
uniprot id: A0A2D3C5J4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

39664:BKM01 RS02715
gene id: 39664:BKM01_RS02715
uniprot id: A0A2D3C4Z9
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

39664:BKM01 RS02980
gene id: 39664:BKM01_RS02980
uniprot id: A0A2D3C566
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

39664:BKM01 RS04140
gene id: 39664:BKM01_RS04140
uniprot id: A0A2D3C5P7
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

39664:BKM01 RS00540
gene id: 39664:BKM01_RS00540
uniprot id: A0A2D3C3W3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

39664:BKM01 RS05875
gene id: 39664:BKM01_RS05875
uniprot id: A0A2D3C6K5
names: Similarity
messages: Belongs to the glutamate synthase family.

39664:BKM01 RS02625
gene id: 39664:BKM01_RS02625
uniprot id: A0A2D3C4X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

39664:BKM01 RS03215
gene id: 39664:BKM01_RS03215
uniprot id: A0A2D3C587
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

39664:BKM01 RS08145
gene id: 39664:BKM01_RS08145
uniprot id: A0A2D3C7N7
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

39664:BKM01 RS09175
gene id: 39664:BKM01_RS09175
uniprot id: A0A2D3C845
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

39664:BKM01 RS09055
gene id: 39664:BKM01_RS09055
uniprot id: A0A2D3C5Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

39664:BKM01 RS09230
gene id: 39664:BKM01_RS09230
uniprot id: A0A2D3C854
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

39664:BKM01 RS00890
gene id: 39664:BKM01_RS00890
uniprot id: A0A2D3C427
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrF family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

39664:BKM01 RS01150
gene id: 39664:BKM01_RS01150
uniprot id: A0A2D3C467
names: Similarity
messages: Belongs to the UPF0166 family.

39664:BKM01 RS06330
gene id: 39664:BKM01_RS06330
uniprot id: A0A2D3C6R0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG.
messages: Cytoplasm

39664:BKM01 RS08775
gene id: 39664:BKM01_RS08775
uniprot id: A0A2D3C7X5
names: Function
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

39664:BKM01 RS10250
gene id: 39664:BKM01_RS10250
uniprot id: A0A2D3C6K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

39664:BKM01 RS03945
gene id: 39664:BKM01_RS03945
uniprot id: A0A2D3C5K9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhB family.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation.

39664:BKM01 RS10220
gene id: 39664:BKM01_RS10220
uniprot id: A0A2D3C8R4
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

39664:BKM01 RS02185
gene id: 39664:BKM01_RS02185
uniprot id: A0A2D3C3D3
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

39664:BKM01 RS06525
gene id: 39664:BKM01_RS06525
uniprot id: A0A2D3C4M9
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

39664:BKM01 RS03085
gene id: 39664:BKM01_RS03085
uniprot id: A0A2D3C3G4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

39664:BKM01 RS05835
gene id: 39664:BKM01_RS05835
uniprot id: A0A2D3C6H1
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

39664:BKM01 RS06930
gene id: 39664:BKM01_RS06930
uniprot id: A0A2D3C734
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

39664:BKM01 RS07595
gene id: 39664:BKM01_RS07595
uniprot id: A0A2D3C595
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

39664:BKM01 RS07355
gene id: 39664:BKM01_RS07355
uniprot id: A0A2D3C7B3
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

39664:BKM01 RS00530
gene id: 39664:BKM01_RS00530
uniprot id: A0A2D3C3W0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

39664:BKM01 RS02420
gene id: 39664:BKM01_RS02420
uniprot id: A0A2D3C3E1
names: Subcellular Location Annotation
messages: Cell membrane

39664:BKM01 RS02440
gene id: 39664:BKM01_RS02440
uniprot id: A0A2D3C4U4
names: Caution
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS06810
gene id: 39664:BKM01_RS06810
uniprot id: A0A2D3C4T4
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

39664:BKM01 RS02400
gene id: 39664:BKM01_RS02400
uniprot id: A0A2D3C4S8
names: Similarity
messages: Belongs to the TrpF family.

39664:BKM01 RS03940
gene id: 39664:BKM01_RS03940
uniprot id: A0A2D3C5K4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

39664:BKM01 RS01480
gene id: 39664:BKM01_RS01480
uniprot id: A0A2D3C4C9
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS01615
gene id: 39664:BKM01_RS01615
uniprot id: A0A2D3C3B1
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

39664:BKM01 RS09360
gene id: 39664:BKM01_RS09360
uniprot id: A0A2D3C885
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS05515
gene id: 39664:BKM01_RS05515
uniprot id: A0A2D3C6B4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Heterotetramer of 2 HacA and 2 HacB proteins.
messages: Hydro-lyase with broad substrate specificity for cis-unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4-tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4-tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B.

39664:BKM01 RS06095
gene id: 39664:BKM01_RS06095
uniprot id: A0A2D3C6P3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

39664:BKM01 RS02630
gene id: 39664:BKM01_RS02630
uniprot id: A0A2D3C4W6
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

39664:BKM01 RS00015
gene id: 39664:BKM01_RS00015
uniprot id: A0A2D3C3L3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

39664:BKM01 RS01560
gene id: 39664:BKM01_RS01560
uniprot id: A0A2D3C3A9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

39664:BKM01 RS06190
gene id: 39664:BKM01_RS06190
uniprot id: A0A2D3C4F9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

39664:BKM01 RS06955
gene id: 39664:BKM01_RS06955
uniprot id: A0A2D3C737
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

39664:BKM01 RS05590
gene id: 39664:BKM01_RS05590
uniprot id: A0A2D3C448
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

39664:BKM01 RS00885
gene id: 39664:BKM01_RS00885
uniprot id: A0A2D3C423
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrG family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

39664:BKM01 RS09185
gene id: 39664:BKM01_RS09185
uniprot id: A0A2D3C9D0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

39664:BKM01 RS04825
gene id: 39664:BKM01_RS04825
uniprot id: A0A2D3C3T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

39664:BKM01 RS07875
gene id: 39664:BKM01_RS07875
uniprot id: A0A2D3C7I0
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

39664:BKM01 RS06335
gene id: 39664:BKM01_RS06335
uniprot id: A0A2D3C6S4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

39664:BKM01 RS08990
gene id: 39664:BKM01_RS08990
uniprot id: A0A2D3C803
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

39664:BKM01 RS06720
gene id: 39664:BKM01_RS06720
uniprot id: A0A2D3C6X9
names: Similarity
messages: Belongs to the UPF0201 family.

39664:BKM01 RS09240
gene id: 39664:BKM01_RS09240
uniprot id: A0A2D3C8B4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

39664:BKM01 RS06015
gene id: 39664:BKM01_RS06015
uniprot id: A0A2D3C4D3
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

39664:BKM01 RS01175
gene id: 39664:BKM01_RS01175
uniprot id: A0A2D3C477
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS09295
gene id: 39664:BKM01_RS09295
uniprot id: A0A2D3C864
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

39664:BKM01 RS10235
gene id: 39664:BKM01_RS10235
uniprot id: A0A2D3C8P5
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

39664:BKM01 RS00580
gene id: 39664:BKM01_RS00580
uniprot id: A0A2D3C3V8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

39664:BKM01 RS02560
gene id: 39664:BKM01_RS02560
uniprot id: A0A2D3C4X9
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

39664:BKM01 RS03390
gene id: 39664:BKM01_RS03390
uniprot id: A0A2D3C598
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

39664:BKM01 RS04925
gene id: 39664:BKM01_RS04925
uniprot id: A0A2D3C621
names: Similarity
messages: Belongs to the UPF0305 family.

39664:BKM01 RS04970
gene id: 39664:BKM01_RS04970
uniprot id: A0A2D3C653
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

39664:BKM01 RS07110
gene id: 39664:BKM01_RS07110
uniprot id: A0A2D3C772
names: Subcellular Location Annotation
messages: Cytoplasm

39664:BKM01 RS01270
gene id: 39664:BKM01_RS01270
uniprot id: A0A2D3C493
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

39664:BKM01 RS00765
gene id: 39664:BKM01_RS00765
uniprot id: A0A2D3C410
names: Similarity
messages: Belongs to the archaeal-type GPI family.

39664:BKM01 RS06180
gene id: 39664:BKM01_RS06180
uniprot id: A0A2D3C9A9
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS09315
gene id: 39664:BKM01_RS09315
uniprot id: A0A2D3C890
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS10630
gene id: 39664:BKM01_RS10630
uniprot id: A0A2D3C798
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

39664:BKM01 RS09645
gene id: 39664:BKM01_RS09645
uniprot id: A0A2D3C8I4
names: Similarity
messages: Belongs to the IMPACT family.

39664:BKM01 RS05465
gene id: 39664:BKM01_RS05465
uniprot id: A0A2D3C6B7
names: Similarity
names: Subunit
messages: Belongs to the CMP-NeuNAc synthase family.
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Belongs to the KdsC family.
messages: Homotetramer.

39664:BKM01 RS06895
gene id: 39664:BKM01_RS06895
uniprot id: A0A2D3C708
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

39664:BKM01 RS04745
gene id: 39664:BKM01_RS04745
uniprot id: A0A2D3C5Z9
names: Similarity
messages: Belongs to the peptidase U62 family.

39664:BKM01 RS02720
gene id: 39664:BKM01_RS02720
uniprot id: A0A2D3C503
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

39664:BKM01 RS01215
gene id: 39664:BKM01_RS01215
uniprot id: A0A2D3C482
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS02180
gene id: 39664:BKM01_RS02180
uniprot id: A0A2D3C4N6
names: Similarity
messages: Belongs to the MEMO1 family.

39664:BKM01 RS06210
gene id: 39664:BKM01_RS06210
uniprot id: A0A2D3C6Q1
names: Similarity
messages: Belongs to the SUI1 family.

39664:BKM01 RS00875
gene id: 39664:BKM01_RS00875
uniprot id: A0A2D3C6U7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

39664:BKM01 RS07495
gene id: 39664:BKM01_RS07495
uniprot id: A0A2D3C7D6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

39664:BKM01 RS10425
gene id: 39664:BKM01_RS10425
uniprot id: A0A2D3C8S3
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

39664:BKM01 RS00950
gene id: 39664:BKM01_RS00950
uniprot id: A0A2D3C6T1
names: Similarity
messages: Belongs to the UPF0107 family.

39664:BKM01 RS00895
gene id: 39664:BKM01_RS00895
uniprot id: A0A2D3C420
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

39664:BKM01 RS08995
gene id: 39664:BKM01_RS08995
uniprot id: A0A2D3C835
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

39664:BKM01 RS00915
gene id: 39664:BKM01_RS00915
uniprot id: A0A2D3C418
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

39664:BKM01 RS09550
gene id: 39664:BKM01_RS09550
uniprot id: A0A2D3C9C3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

39664:BKM01 RS03680
gene id: 39664:BKM01_RS03680
uniprot id: A0A2D3C5E6
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

39664:BKM01 RS01090
gene id: 39664:BKM01_RS01090
uniprot id: A0A2D3C447
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

39664:BKM01 RS02365
gene id: 39664:BKM01_RS02365
uniprot id: A0A2D3C3D8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

39664:BKM01 RS09760
gene id: 39664:BKM01_RS09760
uniprot id: A0A2D3C8E0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

39664:BKM01 RS03110
gene id: 39664:BKM01_RS03110
uniprot id: A0A2D3C572
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

39664:BKM01 RS03830
gene id: 39664:BKM01_RS03830
uniprot id: A0A2D3C5I6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

39664:BKM01 RS02210
gene id: 39664:BKM01_RS02210
uniprot id: A0A2D3C4Q3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

39664:BKM01 RS09515
gene id: 39664:BKM01_RS09515
uniprot id: A0A2D3C8A0
names: Similarity
messages: Belongs to the SDO1/SBDS family.

39664:BKM01 RS01890
gene id: 39664:BKM01_RS01890
uniprot id: A0A2D3C4K0
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS02695
gene id: 39664:BKM01_RS02695
uniprot id: A0A2D3C3F1
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

39664:BKM01 RS01740
gene id: 39664:BKM01_RS01740
uniprot id: A0A2D3C3B4
names: Function
messages: Part of a potassium transport system.

39664:BKM01 RS08225
gene id: 39664:BKM01_RS08225
uniprot id: A0A2D3C5J2
names: Similarity
messages: Belongs to the MCM family.

39664:BKM01 RS03790
gene id: 39664:BKM01_RS03790
uniprot id: A0A2D3C5G1
names: Similarity
messages: Belongs to the glutaredoxin family.

39664:BKM01 RS10130
gene id: 39664:BKM01_RS10130
uniprot id: A0A2D3C8M9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

39664:BKM01 RS03150
gene id: 39664:BKM01_RS03150
uniprot id: A0A2D3C901
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

39664:BKM01 RS01760
gene id: 39664:BKM01_RS01760
uniprot id: A0A2D3C4I1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

39664:BKM01 RS09795
gene id: 39664:BKM01_RS09795
uniprot id: A0A2D3C8D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

39664:BKM01 RS02310
gene id: 39664:BKM01_RS02310
uniprot id: A0A2D3C3D7
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

39664:BKM01 RS07985
gene id: 39664:BKM01_RS07985
uniprot id: A0A2D3C7L0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cell membrane
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Membrane
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

39664:BKM01 RS08320
gene id: 39664:BKM01_RS08320
uniprot id: A0A2D3C7V5
names: Similarity
messages: Belongs to the HerA family.

39664:BKM01 RS00995
gene id: 39664:BKM01_RS00995
uniprot id: A0A2D3C442
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

39664:BKM01 RS01695
gene id: 39664:BKM01_RS01695
uniprot id: A0A2D3C4F4
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

39664:BKM01 RS10445
gene id: 39664:BKM01_RS10445
uniprot id: A0A2D3C6M1
names: Function
messages: Part of a potassium transport system.

39664:BKM01 RS09500
gene id: 39664:BKM01_RS09500
uniprot id: A0A2D3C9A8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

39664:BKM01 RS08655
gene id: 39664:BKM01_RS08655
uniprot id: A0A2D3C9F0
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS07960
gene id: 39664:BKM01_RS07960
uniprot id: A0A2D3C7N6
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

39664:BKM01 RS06435
gene id: 39664:BKM01_RS06435
uniprot id: A0A2D3C6V3
names: Similarity
messages: Belongs to the UPF0215 family.

39664:BKM01 RS04725
gene id: 39664:BKM01_RS04725
uniprot id: A0A2D3C615
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

39664:BKM01 RS03230
gene id: 39664:BKM01_RS03230
uniprot id: A0A2D3C585
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

39664:BKM01 RS00065
gene id: 39664:BKM01_RS00065
uniprot id: A0A2D3C3L6
names: Similarity
messages: Belongs to the band 7/mec-2 family.

39664:BKM01 RS07180
gene id: 39664:BKM01_RS07180
uniprot id: A0A2D3C957
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS02205
gene id: 39664:BKM01_RS02205
uniprot id: A0A2D3C4R8
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

39664:BKM01 RS01895
gene id: 39664:BKM01_RS01895
uniprot id: A0A2D3C4J6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

39664:BKM01 RS10645
gene id: 39664:BKM01_RS10645
uniprot id: A0A2D3C8U6
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

39664:BKM01 RS03915
gene id: 39664:BKM01_RS03915
uniprot id: A0A2D3C3J5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS09950
gene id: 39664:BKM01_RS09950
uniprot id: A0A2D3C8J8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

39664:BKM01 RS09480
gene id: 39664:BKM01_RS09480
uniprot id: A0A2D3C887
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

39664:BKM01 RS00525
gene id: 39664:BKM01_RS00525
uniprot id: A0A2D3C3V5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

39664:BKM01 RS02235
gene id: 39664:BKM01_RS02235
uniprot id: A0A2D3C4P5
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

39664:BKM01 RS02700
gene id: 39664:BKM01_RS02700
uniprot id: A0A2D3C3F0
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

39664:BKM01 RS10520
gene id: 39664:BKM01_RS10520
uniprot id: A0A2D3C8X0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

39664:BKM01 RS08400
gene id: 39664:BKM01_RS08400
uniprot id: A0A2D3C7Q8
names: Similarity
messages: Belongs to the SAICAR synthetase family.

39664:BKM01 RS01865
gene id: 39664:BKM01_RS01865
uniprot id: A0A2D3C4L3
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS00635
gene id: 39664:BKM01_RS00635
uniprot id: A0A2D3C3X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

39664:BKM01 RS00230
gene id: 39664:BKM01_RS00230
uniprot id: A0A2D3C3P8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

39664:BKM01 RS10535
gene id: 39664:BKM01_RS10535
uniprot id: A0A2D3C8U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

39664:BKM01 RS10620
gene id: 39664:BKM01_RS10620
uniprot id: A0A2D3C8X2
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

39664:BKM01 RS00990
gene id: 39664:BKM01_RS00990
uniprot id: A0A2D3C446
names: Similarity
messages: Belongs to the tRNA(His) guanylyltransferase family.

39664:BKM01 RS03160
gene id: 39664:BKM01_RS03160
uniprot id: A0A2D3C578
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

39664:BKM01 RS05745
gene id: 39664:BKM01_RS05745
uniprot id: A0A2D3C480
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

39664:BKM01 RS07865
gene id: 39664:BKM01_RS07865
uniprot id: A0A2D3C7K4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

39664:BKM01 RS03270
gene id: 39664:BKM01_RS03270
uniprot id: A0A2D3C577
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

39664:BKM01 RS07635
gene id: 39664:BKM01_RS07635
uniprot id: A0A2D3C7F6
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

39664:BKM01 RS01300
gene id: 39664:BKM01_RS01300
uniprot id: A0A2D3C399
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

39664:BKM01 RS10075
gene id: 39664:BKM01_RS10075
uniprot id: A0A2D3C8K0
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

39664:BKM01 RS00475
gene id: 39664:BKM01_RS00475
uniprot id: A0A2D3C3U4
names: Similarity
messages: Belongs to the UPF0288 family.

39664:BKM01 RS00800
gene id: 39664:BKM01_RS00800
uniprot id: A0A2D3C408
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

39664:BKM01 RS03660
gene id: 39664:BKM01_RS03660
uniprot id: A0A2D3C5F3
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

39664:BKM01 RS09905
gene id: 39664:BKM01_RS09905
uniprot id: A0A2D3C8F6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

39664:BKM01 RS07850
gene id: 39664:BKM01_RS07850
uniprot id: A0A2D3C7J8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

39664:BKM01 RS08085
gene id: 39664:BKM01_RS08085
uniprot id: A0A2D3C7N3
names: Similarity
messages: Belongs to the GARS family.

39664:BKM01 RS01285
gene id: 39664:BKM01_RS01285
uniprot id: A0A2D3C497
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

39664:BKM01 RS06845
gene id: 39664:BKM01_RS06845
uniprot id: A0A2D3C6Z7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

39664:BKM01 RS01265
gene id: 39664:BKM01_RS01265
uniprot id: A0A2D3C490
names: Similarity
messages: Belongs to the eIF-2-alpha family.

39664:BKM01 RS08020
gene id: 39664:BKM01_RS08020
uniprot id: A0A2D3C7M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

39664:BKM01 RS06965
gene id: 39664:BKM01_RS06965
uniprot id: A3QPW7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

39664:BKM01 RS05845
gene id: 39664:BKM01_RS05845
uniprot id: A0A2D3C6H3
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS09455
gene id: 39664:BKM01_RS09455
uniprot id: A0A2D3C9G0
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

39664:BKM01 RS08970
gene id: 39664:BKM01_RS08970
uniprot id: A0A2D3C843
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

39664:BKM01 RS09180
gene id: 39664:BKM01_RS09180
uniprot id: A0A2D3C884
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

39664:BKM01 RS04015
gene id: 39664:BKM01_RS04015
uniprot id: A0A2D3C3J9
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS03950
gene id: 39664:BKM01_RS03950
uniprot id: A0A2D3C5J6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: Binds 2 [Ni-4Fe-4S] clusters per heterotetramer.
messages: Binds 7 [4Fe-4S] clusters per heterotetramer.
messages: Cluster B is an all-cysteinyl-liganded 4Fe-4S cluster; cluster C is a mixed Ni-Fe-S cluster which is the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe-4S cluster that bridges the two subunits of the CODH dimer. Contains two additional 4Fe-4S clusters, dubbed E and F, that probably transport electrons from ferredoxin to the B cluster.
messages: Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.

39664:BKM01 RS06440
gene id: 39664:BKM01_RS06440
uniprot id: A0A2D3C6S8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

39664:BKM01 RS08125
gene id: 39664:BKM01_RS08125
uniprot id: A0A2D3C7R1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

39664:BKM01 RS01730
gene id: 39664:BKM01_RS01730
uniprot id: A0A2D3C4H5
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

39664:BKM01 RS03695
gene id: 39664:BKM01_RS03695
uniprot id: A0A2D3C5F0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

39664:BKM01 RS09215
gene id: 39664:BKM01_RS09215
uniprot id: A0A2D3C618
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

39664:BKM01 RS01685
gene id: 39664:BKM01_RS01685
uniprot id: A0A2D3C3B2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS07350
gene id: 39664:BKM01_RS07350
uniprot id: A0A2D3C7B2
names: Similarity
messages: Belongs to the HsdR family.

39664:BKM01 RS05135
gene id: 39664:BKM01_RS05135
uniprot id: A0A2D3C655
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

39664:BKM01 RS05530
gene id: 39664:BKM01_RS05530
uniprot id: A0A2D3C6C7
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS02385
gene id: 39664:BKM01_RS02385
uniprot id: A0A2D3C4V0
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

39664:BKM01 RS01295
gene id: 39664:BKM01_RS01295
uniprot id: A0A2D3C496
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

39664:BKM01 RS06935
gene id: 39664:BKM01_RS06935
uniprot id: A0A2D3C739
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

39664:BKM01 RS07695
gene id: 39664:BKM01_RS07695
uniprot id: A0A2D3C7H4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

39664:BKM01 RS07500
gene id: 39664:BKM01_RS07500
uniprot id: A0A2D3C7E0
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

39664:BKM01 RS05970
gene id: 39664:BKM01_RS05970
uniprot id: A0A2D3C4B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

39664:BKM01 RS06075
gene id: 39664:BKM01_RS06075
uniprot id: A0A2D3C4D6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

39664:BKM01 RS10395
gene id: 39664:BKM01_RS10395
uniprot id: A0A2D3C6L2
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS00880
gene id: 39664:BKM01_RS00880
uniprot id: A0A2D3C425
names: Similarity
messages: Belongs to the MtrH family.

39664:BKM01 RS10415
gene id: 39664:BKM01_RS10415
uniprot id: A0A2D3C8W4
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

39664:BKM01 RS05740
gene id: 39664:BKM01_RS05740
uniprot id: A0A2D3C6H0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

39664:BKM01 RS03610
gene id: 39664:BKM01_RS03610
uniprot id: A0A2D3C5E8
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

39664:BKM01 RS10005
gene id: 39664:BKM01_RS10005
uniprot id: A0A2D3C8K6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

39664:BKM01 RS01745
gene id: 39664:BKM01_RS01745
uniprot id: A0A2D3C4G4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

39664:BKM01 RS09385
gene id: 39664:BKM01_RS09385
uniprot id: A0A2D3C642
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS04175
gene id: 39664:BKM01_RS04175
uniprot id: A0A2D3C3K5
names: Similarity
messages: Belongs to the DEAD box helicase family.

39664:BKM01 RS03955
gene id: 39664:BKM01_RS03955
uniprot id: A0A2D3C5J8
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS07440
gene id: 39664:BKM01_RS07440
uniprot id: A0A2D3C7C5
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

39664:BKM01 RS04100
gene id: 39664:BKM01_RS04100
uniprot id: A0A2D3C5P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

39664:BKM01 RS10195
gene id: 39664:BKM01_RS10195
uniprot id: A0A2D3C6J4
names: Similarity
messages: Belongs to the thymidylate kinase family.

39664:BKM01 RS01565
gene id: 39664:BKM01_RS01565
uniprot id: A0A2D3C3A8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Cytoplasm

39664:BKM01 RS09870
gene id: 39664:BKM01_RS09870
uniprot id: A0A2D3C6C2
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

39664:BKM01 RS00430
gene id: 39664:BKM01_RS00430
uniprot id: A0A2D3C3U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

39664:BKM01 RS07675
gene id: 39664:BKM01_RS07675
uniprot id: A0A2D3C7H5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

39664:BKM01 RS01425
gene id: 39664:BKM01_RS01425
uniprot id: A0A2D3C4B9
names: Function
messages: Part of a potassium transport system.

39664:BKM01 RS00095
gene id: 39664:BKM01_RS00095
uniprot id: A0A2D3C3M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

39664:BKM01 RS03585
gene id: 39664:BKM01_RS03585
uniprot id: A0A2D3C5E9
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

39664:BKM01 RS03770
gene id: 39664:BKM01_RS03770
uniprot id: A0A2D3C5H7
names: Similarity
messages: Belongs to the TrpC family.

39664:BKM01 RS03985
gene id: 39664:BKM01_RS03985
uniprot id: A0A2D3C5L7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

39664:BKM01 RS05780
gene id: 39664:BKM01_RS05780
uniprot id: A0A2D3C6F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

39664:BKM01 RS02585
gene id: 39664:BKM01_RS02585
uniprot id: A0A2D3C4V1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

39664:BKM01 RS02920
gene id: 39664:BKM01_RS02920
uniprot id: A0A2D3C516
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS05415
gene id: 39664:BKM01_RS05415
uniprot id: A0A2D3C6A6
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS10530
gene id: 39664:BKM01_RS10530
uniprot id: A0A2D3C8S5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

39664:BKM01 RS02190
gene id: 39664:BKM01_RS02190
uniprot id: A0A2D3C3D2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

39664:BKM01 RS07405
gene id: 39664:BKM01_RS07405
uniprot id: A0A2D3C7C1
names: Similarity
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

39664:BKM01 RS01190
gene id: 39664:BKM01_RS01190
uniprot id: A0A2D3C395
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS06820
gene id: 39664:BKM01_RS06820
uniprot id: A0A2D3C715
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

39664:BKM01 RS02145
gene id: 39664:BKM01_RS02145
uniprot id: A0A2D3C4Q8
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS03795
gene id: 39664:BKM01_RS03795
uniprot id: A0A2D3C5G5
names: Subcellular Location Annotation
messages: Cytoplasm

39664:BKM01 RS07030
gene id: 39664:BKM01_RS07030
uniprot id: A0A2D3C4X7
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

39664:BKM01 RS03095
gene id: 39664:BKM01_RS03095
uniprot id: A0A2D3C584
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

39664:BKM01 RS06020
gene id: 39664:BKM01_RS06020
uniprot id: A0A2D3C4C7
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

39664:BKM01 RS06860
gene id: 39664:BKM01_RS06860
uniprot id: A0A2D3C714
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

39664:BKM01 RS02670
gene id: 39664:BKM01_RS02670
uniprot id: A0A2D3C4Z8
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

39664:BKM01 RS09235
gene id: 39664:BKM01_RS09235
uniprot id: A0A2D3C894
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS03640
gene id: 39664:BKM01_RS03640
uniprot id: A0A2D3C3I5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

39664:BKM01 RS09110
gene id: 39664:BKM01_RS09110
uniprot id: A0A2D3C5Z8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

39664:BKM01 RS08565
gene id: 39664:BKM01_RS08565
uniprot id: A0A2D3C7Z2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

39664:BKM01 RS09170
gene id: 39664:BKM01_RS09170
uniprot id: A0A2D3C868
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

39664:BKM01 RS01135
gene id: 39664:BKM01_RS01135
uniprot id: A0A2D3C931
names: Similarity
messages: Belongs to the MoaB/Mog family.

39664:BKM01 RS06375
gene id: 39664:BKM01_RS06375
uniprot id: A0A2D3C6T9
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

39664:BKM01 RS02845
gene id: 39664:BKM01_RS02845
uniprot id: A0A2D3C501
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

39664:BKM01 RS01390
gene id: 39664:BKM01_RS01390
uniprot id: A0A2D3C4B7
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

39664:BKM01 RS01775
gene id: 39664:BKM01_RS01775
uniprot id: A0A2D3C4H9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

39664:BKM01 RS07880
gene id: 39664:BKM01_RS07880
uniprot id: A0A2D3C7J1
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

39664:BKM01 RS03505
gene id: 39664:BKM01_RS03505
uniprot id: A0A2D3C3I0
names: Similarity
messages: Belongs to the UPF0280 family.

39664:BKM01 RS02620
gene id: 39664:BKM01_RS02620
uniprot id: A0A2D3C4Y3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

39664:BKM01 RS09350
gene id: 39664:BKM01_RS09350
uniprot id: A0A2D3C8B5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

39664:BKM01 RS00240
gene id: 39664:BKM01_RS00240
uniprot id: A0A2D3C3R0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

39664:BKM01 RS01860
gene id: 39664:BKM01_RS01860
uniprot id: A0A2D3C4I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

39664:BKM01 RS01110
gene id: 39664:BKM01_RS01110
uniprot id: A0A2D3C465
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

39664:BKM01 RS07805
gene id: 39664:BKM01_RS07805
uniprot id: A0A2D3C7J5
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

39664:BKM01 RS01070
gene id: 39664:BKM01_RS01070
uniprot id: A0A2D3C389
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

39664:BKM01 RS00860
gene id: 39664:BKM01_RS00860
uniprot id: A0A2D3C416
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

39664:BKM01 RS06380
gene id: 39664:BKM01_RS06380
uniprot id: A0A2D3C958
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

39664:BKM01 RS02840
gene id: 39664:BKM01_RS02840
uniprot id: A0A2D3C505
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

39664:BKM01 RS01610
gene id: 39664:BKM01_RS01610
uniprot id: A0A2D3C6V8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

39664:BKM01 RS03710
gene id: 39664:BKM01_RS03710
uniprot id: A0A2D3C970
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

39664:BKM01 RS10140
gene id: 39664:BKM01_RS10140
uniprot id: A0A2D3C8N3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

39664:BKM01 RS09505
gene id: 39664:BKM01_RS09505
uniprot id: A0A2D3C667
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

39664:BKM01 RS09685
gene id: 39664:BKM01_RS09685
uniprot id: A0A2D3C8D1
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

39664:BKM01 RS03565
gene id: 39664:BKM01_RS03565
uniprot id: A0A2D3C3I3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

39664:BKM01 RS00310
gene id: 39664:BKM01_RS00310
uniprot id: A0A2D3C3S6
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

39664:BKM01 RS04965
gene id: 39664:BKM01_RS04965
uniprot id: A0A2D3C622
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS03715
gene id: 39664:BKM01_RS03715
uniprot id: A0A2D3C5G2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

39664:BKM01 RS02610
gene id: 39664:BKM01_RS02610
uniprot id: A0A2D3C4Y1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

39664:BKM01 RS00195
gene id: 39664:BKM01_RS00195
uniprot id: A0A2D3C3Q3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

39664:BKM01 RS02335
gene id: 39664:BKM01_RS02335
uniprot id: A0A2D3C4U2
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

39664:BKM01 RS08470
gene id: 39664:BKM01_RS08470
uniprot id: A0A2D3C5P3
names: Similarity
messages: Belongs to the HsdR family.

39664:BKM01 RS03145
gene id: 39664:BKM01_RS03145
uniprot id: A0A2D3C558
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

39664:BKM01 RS09540
gene id: 39664:BKM01_RS09540
uniprot id: A0A2D3C897
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

39664:BKM01 RS08370
gene id: 39664:BKM01_RS08370
uniprot id: A0A2D3C7T9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS01755
gene id: 39664:BKM01_RS01755
uniprot id: A0A2D3C4H6
names: Similarity
messages: Belongs to the CutA family.

39664:BKM01 RS06575
gene id: 39664:BKM01_RS06575
uniprot id: A0A2D3C4P8
names: Similarity
messages: Belongs to the UPF0251 family.

39664:BKM01 RS09590
gene id: 39664:BKM01_RS09590
uniprot id: A0A2D3C8D8
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS03375
gene id: 39664:BKM01_RS03375
uniprot id: A0A2D3C596
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS00345
gene id: 39664:BKM01_RS00345
uniprot id: A0A2D3C3R7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS06580
gene id: 39664:BKM01_RS06580
uniprot id: A0A2D3C4N9
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

39664:BKM01 RS05950
gene id: 39664:BKM01_RS05950
uniprot id: A0A2D3C6J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

39664:BKM01 RS09980
gene id: 39664:BKM01_RS09980
uniprot id: A0A2D3C8K7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

39664:BKM01 RS05615
gene id: 39664:BKM01_RS05615
uniprot id: A0A2D3C6E6
names: Similarity
messages: Belongs to the PurH family.

39664:BKM01 RS03560
gene id: 39664:BKM01_RS03560
uniprot id: A0A2D3C3I2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

39664:BKM01 RS06010
gene id: 39664:BKM01_RS06010
uniprot id: A0A2D3C6L8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

39664:BKM01 RS02175
gene id: 39664:BKM01_RS02175
uniprot id: A0A2D3C4P4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

39664:BKM01 RS01830
gene id: 39664:BKM01_RS01830
uniprot id: A0A2D3C4J3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: FPO is composed of at least 12 different subunits. Subunits FpoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: FPO shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to quinones in the F(420)H(2):heterodisulfide oxidoreduction chain. The immediate electron acceptor for the enzyme in this species is believed to be methanophenazine. Couples the redox reaction to proton translocation (for every two electrons transferred, 0.9 hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
messages: Membrane

39664:BKM01 RS06920
gene id: 39664:BKM01_RS06920
uniprot id: A0A2D3C4V9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

39664:BKM01 RS02690
gene id: 39664:BKM01_RS02690
uniprot id: A0A2D3C4W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane

39664:BKM01 RS04990
gene id: 39664:BKM01_RS04990
uniprot id: A0A2D3C638
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

39664:BKM01 RS01915
gene id: 39664:BKM01_RS01915
uniprot id: A0A2D3C4M0
names: Function
names: Similarity
messages: Belongs to the glutamate synthase family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

39664:BKM01 RS10290
gene id: 39664:BKM01_RS10290
uniprot id: A0A2D3C8N2
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS09860
gene id: 39664:BKM01_RS09860
uniprot id: A0A2D3C8I3
names: Similarity
messages: Belongs to the UPF0758 family.

39664:BKM01 RS00035
gene id: 39664:BKM01_RS00035
uniprot id: A0A2D3C3L8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

39664:BKM01 RS08350
gene id: 39664:BKM01_RS08350
uniprot id: A0A2D3C5L3
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

39664:BKM01 RS09835
gene id: 39664:BKM01_RS09835
uniprot id: A0A2D3C8L5
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

39664:BKM01 RS08080
gene id: 39664:BKM01_RS08080
uniprot id: A0A2D3C7M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

39664:BKM01 RS06960
gene id: 39664:BKM01_RS06960
uniprot id: A0A2D3C721
names: Similarity
messages: Belongs to the ClpA/ClpB family.

39664:BKM01 RS08315
gene id: 39664:BKM01_RS08315
uniprot id: A0A2D3C7S9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

39664:BKM01 RS00320
gene id: 39664:BKM01_RS00320
uniprot id: A0A2D3C8Y6
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS01495
gene id: 39664:BKM01_RS01495
uniprot id: A0A2D3C4D8
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

39664:BKM01 RS06450
gene id: 39664:BKM01_RS06450
uniprot id: A0A2D3C6U9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

39664:BKM01 RS03040
gene id: 39664:BKM01_RS03040
uniprot id: A0A2D3C536
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS04935
gene id: 39664:BKM01_RS04935
uniprot id: A0A2D3C620
names: Similarity
messages: Belongs to the UPF0237 family.

39664:BKM01 RS09940
gene id: 39664:BKM01_RS09940
uniprot id: A0A2D3C8N4
names: Similarity
messages: Belongs to the UPF0147 family.

39664:BKM01 RS02945
gene id: 39664:BKM01_RS02945
uniprot id: A0A2D3C534
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

39664:BKM01 RS04715
gene id: 39664:BKM01_RS04715
uniprot id: A0A2D3C3R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

39664:BKM01 RS04070
gene id: 39664:BKM01_RS04070
uniprot id: A0A2D3C5M0
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

39664:BKM01 RS09365
gene id: 39664:BKM01_RS09365
uniprot id: A0A2D3C8A3
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS01815
gene id: 39664:BKM01_RS01815
uniprot id: A0A2D3C4K5
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

39664:BKM01 RS09810
gene id: 39664:BKM01_RS09810
uniprot id: A0A2D3C6C1
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

39664:BKM01 RS03805
gene id: 39664:BKM01_RS03805
uniprot id: A0A2D3C3J1
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

39664:BKM01 RS03685
gene id: 39664:BKM01_RS03685
uniprot id: A0A2D3C3I6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

39664:BKM01 RS09575
gene id: 39664:BKM01_RS09575
uniprot id: A0A2D3C8F5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

39664:BKM01 RS01855
gene id: 39664:BKM01_RS01855
uniprot id: A0A2D3C3B8
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS04870
gene id: 39664:BKM01_RS04870
uniprot id: A0A2D3C619
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

39664:BKM01 RS03185
gene id: 39664:BKM01_RS03185
uniprot id: A0A2D3C563
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

39664:BKM01 RS01735
gene id: 39664:BKM01_RS01735
uniprot id: A0A2D3C3B5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

39664:BKM01 RS00900
gene id: 39664:BKM01_RS00900
uniprot id: A0A2D3C424
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

39664:BKM01 RS00445
gene id: 39664:BKM01_RS00445
uniprot id: A0A2D3C3T8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

39664:BKM01 RS07550
gene id: 39664:BKM01_RS07550
uniprot id: A0A2D3C7E8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

39664:BKM01 RS00755
gene id: 39664:BKM01_RS00755
uniprot id: A0A2D3C3Z9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

39664:BKM01 RS01445
gene id: 39664:BKM01_RS01445
uniprot id: A0A2D3C4C2
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

39664:BKM01 RS10460
gene id: 39664:BKM01_RS10460
uniprot id: A0A2D3C8Q5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS07920
gene id: 39664:BKM01_RS07920
uniprot id: A0A2D3C7M1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
messages: Monomer.

39664:BKM01 RS03590
gene id: 39664:BKM01_RS03590
uniprot id: A0A2D3C5E3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS08550
gene id: 39664:BKM01_RS08550
uniprot id: A0A2D3C994
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

39664:BKM01 RS01355
gene id: 39664:BKM01_RS01355
uniprot id: A0A2D3C3A0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

39664:BKM01 RS00870
gene id: 39664:BKM01_RS00870
uniprot id: A0A2D3C421
names: Similarity
messages: Belongs to the HdrB family.

39664:BKM01 RS08090
gene id: 39664:BKM01_RS08090
uniprot id: A0A2D3C7R2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS03090
gene id: 39664:BKM01_RS03090
uniprot id: A0A2D3C547
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

39664:BKM01 RS03855
gene id: 39664:BKM01_RS03855
uniprot id: A0A2D3C909
names: Similarity
messages: Belongs to the SfsA family.

39664:BKM01 RS06915
gene id: 39664:BKM01_RS06915
uniprot id: A0A2D3C727
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

39664:BKM01 RS06870
gene id: 39664:BKM01_RS06870
uniprot id: A0A2D3C4U5
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS04075
gene id: 39664:BKM01_RS04075
uniprot id: A0A2D3C5Q6
names: Similarity
messages: Belongs to the DMRL synthase family.

39664:BKM01 RS00210
gene id: 39664:BKM01_RS00210
uniprot id: A0A2D3C3P9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

39664:BKM01 RS07090
gene id: 39664:BKM01_RS07090
uniprot id: A0A2D3C758
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

39664:BKM01 RS03370
gene id: 39664:BKM01_RS03370
uniprot id: A0A2D3C591
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS09290
gene id: 39664:BKM01_RS09290
uniprot id: A0A2D3C886
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

39664:BKM01 RS10525
gene id: 39664:BKM01_RS10525
uniprot id: A0A2D3C8Y3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

39664:BKM01 RS09245
gene id: 39664:BKM01_RS09245
uniprot id: A0A2D3C865
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

39664:BKM01 RS08335
gene id: 39664:BKM01_RS08335
uniprot id: A0A2D3C7P4
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

39664:BKM01 RS01950
gene id: 39664:BKM01_RS01950
uniprot id: A0A2D3C4K4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS01655
gene id: 39664:BKM01_RS01655
uniprot id: A0A2D3C4G3
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

39664:BKM01 RS10275
gene id: 39664:BKM01_RS10275
uniprot id: A0A2D3C8U9
names: Subcellular Location Annotation
messages: Membrane

39664:BKM01 RS01500
gene id: 39664:BKM01_RS01500
uniprot id: A0A2D3C4D1
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

39664:BKM01 RS07415
gene id: 39664:BKM01_RS07415
uniprot id: A0A2D3C7C0
names: Similarity
messages: Belongs to the FKBP-type PPIase family.