391623:TERMP RS07695
gene id: 391623:TERMP_RS07695
uniprot id: F0LIS6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

391623:TERMP RS05480
gene id: 391623:TERMP_RS05480
uniprot id: F0LMU7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

391623:TERMP RS05090
gene id: 391623:TERMP_RS05090
uniprot id: F0LML7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

391623:TERMP RS10965
gene id: 391623:TERMP_RS10965
uniprot id: F0LN51
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

391623:TERMP RS05160
gene id: 391623:TERMP_RS05160
uniprot id: F0LMN0
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

391623:TERMP RS05700
gene id: 391623:TERMP_RS05700
uniprot id: F0LMZ0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

391623:TERMP RS08510
gene id: 391623:TERMP_RS08510
uniprot id: F0LJQ1
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

391623:TERMP RS09370
gene id: 391623:TERMP_RS09370
uniprot id: F0LKN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

391623:TERMP RS10355
gene id: 391623:TERMP_RS10355
uniprot id: F0LLW6
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS08145
gene id: 391623:TERMP_RS08145
uniprot id: F0LJ98
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

391623:TERMP RS00575
gene id: 391623:TERMP_RS00575
uniprot id: F0LHL2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

391623:TERMP RS09415
gene id: 391623:TERMP_RS09415
uniprot id: F0LKP3
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

391623:TERMP RS10715
gene id: 391623:TERMP_RS10715
uniprot id: F0LMB7
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

391623:TERMP RS00455
gene id: 391623:TERMP_RS00455
uniprot id: F0LHB0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

391623:TERMP RS00570
gene id: 391623:TERMP_RS00570
uniprot id: F0LHL1
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS05400
gene id: 391623:TERMP_RS05400
uniprot id: F0LMT1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

391623:TERMP RS08690
gene id: 391623:TERMP_RS08690
uniprot id: F0LK20
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

391623:TERMP RS00470
gene id: 391623:TERMP_RS00470
uniprot id: F0LHB3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

391623:TERMP RS00590
gene id: 391623:TERMP_RS00590
uniprot id: F0LHL5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

391623:TERMP RS08635
gene id: 391623:TERMP_RS08635
uniprot id: F0LJS9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

391623:TERMP RS01705
gene id: 391623:TERMP_RS01705
uniprot id: F0LIW8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

391623:TERMP RS05680
gene id: 391623:TERMP_RS05680
uniprot id: F0LMY6
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS04445
gene id: 391623:TERMP_RS04445
uniprot id: F0LM22
names: Similarity
messages: Belongs to the UPF0107 family.

391623:TERMP RS03535
gene id: 391623:TERMP_RS03535
uniprot id: F0LKV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutaredoxin family.
messages: Membrane

391623:TERMP RS03020
gene id: 391623:TERMP_RS03020
uniprot id: F0LKC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

391623:TERMP RS05475
gene id: 391623:TERMP_RS05475
uniprot id: F0LMU6
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

391623:TERMP RS04370
gene id: 391623:TERMP_RS04370
uniprot id: F0LLS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

391623:TERMP RS09955
gene id: 391623:TERMP_RS09955
uniprot id: F0LLF3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

391623:TERMP RS04030
gene id: 391623:TERMP_RS04030
uniprot id: F0LLD4
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS03760
gene id: 391623:TERMP_RS03760
uniprot id: F0LL77
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

391623:TERMP RS01355
gene id: 391623:TERMP_RS01355
uniprot id: F0LIH2
names: Similarity
messages: Belongs to the FUN14 family.

391623:TERMP RS09770
gene id: 391623:TERMP_RS09770
uniprot id: F0LL43
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS01990
gene id: 391623:TERMP_RS01990
uniprot id: F0LJ28
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

391623:TERMP RS03610
gene id: 391623:TERMP_RS03610
uniprot id: F0LKX1
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

391623:TERMP RS10735
gene id: 391623:TERMP_RS10735
uniprot id: F0LMC1
names: Similarity
messages: Belongs to the threonine synthase family.

391623:TERMP RS00680
gene id: 391623:TERMP_RS00680
uniprot id: F0LHN1
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

391623:TERMP RS04975
gene id: 391623:TERMP_RS04975
uniprot id: F0LMJ4
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase family.

391623:TERMP RS02910
gene id: 391623:TERMP_RS02910
uniprot id: F0LKA4
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

391623:TERMP RS01170
gene id: 391623:TERMP_RS01170
uniprot id: F0LI62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

391623:TERMP RS00525
gene id: 391623:TERMP_RS00525
uniprot id: F0LHC4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

391623:TERMP RS01305
gene id: 391623:TERMP_RS01305
uniprot id: F0LIG2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

391623:TERMP RS03515
gene id: 391623:TERMP_RS03515
uniprot id: F0LKV2
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

391623:TERMP RS10170
gene id: 391623:TERMP_RS10170
uniprot id: F0LLJ8
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

391623:TERMP RS01890
gene id: 391623:TERMP_RS01890
uniprot id: F0LJ07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

391623:TERMP RS09070
gene id: 391623:TERMP_RS09070
uniprot id: F0LKH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

391623:TERMP RS05970
gene id: 391623:TERMP_RS05970
uniprot id: F0LN44
names: Similarity
messages: Belongs to the UPF0252 family.

391623:TERMP RS02510
gene id: 391623:TERMP_RS02510
uniprot id: F0LJU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

391623:TERMP RS01655
gene id: 391623:TERMP_RS01655
uniprot id: F0LIN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

391623:TERMP RS06485
gene id: 391623:TERMP_RS06485
uniprot id: F0LHF4
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

391623:TERMP RS05665
gene id: 391623:TERMP_RS05665
uniprot id: F0LMY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

391623:TERMP RS08960
gene id: 391623:TERMP_RS08960
uniprot id: F0LK75
names: Similarity
messages: Belongs to the MoaD family.

391623:TERMP RS06040
gene id: 391623:TERMP_RS06040
uniprot id: F0LGX9
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS05455
gene id: 391623:TERMP_RS05455
uniprot id: F0LMU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

391623:TERMP RS07940
gene id: 391623:TERMP_RS07940
uniprot id: F0LJ55
names: Similarity
messages: Belongs to the malic enzymes family.

391623:TERMP RS02075
gene id: 391623:TERMP_RS02075
uniprot id: F0LJ46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

391623:TERMP RS10655
gene id: 391623:TERMP_RS10655
uniprot id: F0LMA4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

391623:TERMP RS00490
gene id: 391623:TERMP_RS00490
uniprot id: F0LHB7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

391623:TERMP RS02280
gene id: 391623:TERMP_RS02280
uniprot id: F0LJG7
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

391623:TERMP RS07430
gene id: 391623:TERMP_RS07430
uniprot id: F0LIE6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

391623:TERMP RS04565
gene id: 391623:TERMP_RS04565
uniprot id: F0LM45
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

391623:TERMP RS11600
gene id: 391623:TERMP_RS11600
uniprot id: F0LHK0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

391623:TERMP RS06730
gene id: 391623:TERMP_RS06730
uniprot id: F0LHK3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

391623:TERMP RS05130
gene id: 391623:TERMP_RS05130
uniprot id: F0LMM5
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS00240
gene id: 391623:TERMP_RS00240
uniprot id: F0LH65
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.

391623:TERMP RS04965
gene id: 391623:TERMP_RS04965
uniprot id: F0LMJ2
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

391623:TERMP RS10745
gene id: 391623:TERMP_RS10745
uniprot id: F0LMC3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

391623:TERMP RS03400
gene id: 391623:TERMP_RS03400
uniprot id: F0LKT1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

391623:TERMP RS00645
gene id: 391623:TERMP_RS00645
uniprot id: F0LHM5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

391623:TERMP RS06330
gene id: 391623:TERMP_RS06330
uniprot id: F0LH43
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

391623:TERMP RS10120
gene id: 391623:TERMP_RS10120
uniprot id: F0LLI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

391623:TERMP RS08225
gene id: 391623:TERMP_RS08225
uniprot id: F0LJB5
names: Similarity
messages: Belongs to the peptidase M20A family.

391623:TERMP RS00745
gene id: 391623:TERMP_RS00745
uniprot id: F0LHP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

391623:TERMP RS06800
gene id: 391623:TERMP_RS06800
uniprot id: F0LHU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

391623:TERMP RS02380
gene id: 391623:TERMP_RS02380
uniprot id: F0LJI8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

391623:TERMP RS01690
gene id: 391623:TERMP_RS01690
uniprot id: F0LIN7
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

391623:TERMP RS09990
gene id: 391623:TERMP_RS09990
uniprot id: F0LLG0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

391623:TERMP RS07350
gene id: 391623:TERMP_RS07350
uniprot id: F0LIC9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

391623:TERMP RS04175
gene id: 391623:TERMP_RS04175
uniprot id: F0LLN8
names: Similarity
messages: Belongs to the glutaredoxin family.

391623:TERMP RS07775
gene id: 391623:TERMP_RS07775
uniprot id: F0LIU3
names: Similarity
messages: Belongs to the UPF0111 family.

391623:TERMP RS06315
gene id: 391623:TERMP_RS06315
uniprot id: F0LH40
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

391623:TERMP RS02140
gene id: 391623:TERMP_RS02140
uniprot id: F0LJD9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

391623:TERMP RS00545
gene id: 391623:TERMP_RS00545
uniprot id: F0LHK6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

391623:TERMP RS08215
gene id: 391623:TERMP_RS08215
uniprot id: F0LJB3
names: Similarity
messages: Belongs to the phosphohexose mutase family.

391623:TERMP RS05620
gene id: 391623:TERMP_RS05620
uniprot id: F0LMX4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily.
messages: Cytoplasm
messages: Homodimer.

391623:TERMP RS05610
gene id: 391623:TERMP_RS05610
uniprot id: F0LMX2
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

391623:TERMP RS01450
gene id: 391623:TERMP_RS01450
uniprot id: F0LIJ0
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS00780
gene id: 391623:TERMP_RS00780
uniprot id: F0LHQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

391623:TERMP RS03575
gene id: 391623:TERMP_RS03575
uniprot id: F0LKW4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

391623:TERMP RS11305
gene id: 391623:TERMP_RS11305
uniprot id: F0LHX5
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS10125
gene id: 391623:TERMP_RS10125
uniprot id: F0LLI8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

391623:TERMP RS02385
gene id: 391623:TERMP_RS02385
uniprot id: F0LJI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

391623:TERMP RS01675
gene id: 391623:TERMP_RS01675
uniprot id: F0LIN4
names: Similarity
messages: Belongs to the peptidase U62 family.

391623:TERMP RS05690
gene id: 391623:TERMP_RS05690
uniprot id: F0LMY8
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS05420
gene id: 391623:TERMP_RS05420
uniprot id: F0LMT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

391623:TERMP RS10240
gene id: 391623:TERMP_RS10240
uniprot id: F0LLU1
names: Similarity
messages: Belongs to the UPF0175 family.

391623:TERMP RS08345
gene id: 391623:TERMP_RS08345
uniprot id: F0LJL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

391623:TERMP RS00995
gene id: 391623:TERMP_RS00995
uniprot id: F0LI28
names: Similarity
messages: Belongs to the thymidylate kinase family.

391623:TERMP RS04995
gene id: 391623:TERMP_RS04995
uniprot id: F0LMJ8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

391623:TERMP RS01720
gene id: 391623:TERMP_RS01720
uniprot id: F0LIX1
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

391623:TERMP RS01725
gene id: 391623:TERMP_RS01725
uniprot id: F0LIX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

391623:TERMP RS06740
gene id: 391623:TERMP_RS06740
uniprot id: F0LHT2
names: Similarity
messages: Belongs to the HypE family.

391623:TERMP RS07160
gene id: 391623:TERMP_RS07160
uniprot id: F0LI90
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

391623:TERMP RS10765
gene id: 391623:TERMP_RS10765
uniprot id: F0LMC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

391623:TERMP RS02410
gene id: 391623:TERMP_RS02410
uniprot id: F0LJJ5
names: Similarity
messages: Belongs to the peptidase S49 family.

391623:TERMP RS07735
gene id: 391623:TERMP_RS07735
uniprot id: F0LIT4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

391623:TERMP RS05555
gene id: 391623:TERMP_RS05555
uniprot id: F0LMW2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

391623:TERMP RS03850
gene id: 391623:TERMP_RS03850
uniprot id: F0LL95
names: Similarity
messages: Belongs to the pyruvate kinase family.

391623:TERMP RS03945
gene id: 391623:TERMP_RS03945
uniprot id: F0LLB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

391623:TERMP RS06680
gene id: 391623:TERMP_RS06680
uniprot id: F0LHJ3
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

391623:TERMP RS06105
gene id: 391623:TERMP_RS06105
uniprot id: F0LGZ3
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

391623:TERMP RS08950
gene id: 391623:TERMP_RS08950
uniprot id: F0LK73
names: Similarity
messages: Belongs to the GbsR family.

391623:TERMP RS01025
gene id: 391623:TERMP_RS01025
uniprot id: F0LI34
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

391623:TERMP RS00105
gene id: 391623:TERMP_RS00105
uniprot id: F0LGW0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

391623:TERMP RS09700
gene id: 391623:TERMP_RS09700
uniprot id: F0LL28
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS00650
gene id: 391623:TERMP_RS00650
uniprot id: F0LHM6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

391623:TERMP RS06290
gene id: 391623:TERMP_RS06290
uniprot id: F0LH34
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

391623:TERMP RS05805
gene id: 391623:TERMP_RS05805
uniprot id: F0LN11
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

391623:TERMP RS03590
gene id: 391623:TERMP_RS03590
uniprot id: F0LKW7
names: Similarity
messages: Belongs to the MoaB/Mog family.

391623:TERMP RS04410
gene id: 391623:TERMP_RS04410
uniprot id: F0LLT5
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

391623:TERMP RS06370
gene id: 391623:TERMP_RS06370
uniprot id: F0LHD0
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

391623:TERMP RS07590
gene id: 391623:TERMP_RS07590
uniprot id: F0LIQ6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

391623:TERMP RS08755
gene id: 391623:TERMP_RS08755
uniprot id: F0LK33
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

391623:TERMP RS02200
gene id: 391623:TERMP_RS02200
uniprot id: F0LJF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm

391623:TERMP RS09265
gene id: 391623:TERMP_RS09265
uniprot id: F0LKL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

391623:TERMP RS00795
gene id: 391623:TERMP_RS00795
uniprot id: F0LHQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

391623:TERMP RS10690
gene id: 391623:TERMP_RS10690
uniprot id: F0LMB1
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

391623:TERMP RS04630
gene id: 391623:TERMP_RS04630
uniprot id: F0LM59
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.

391623:TERMP RS00330
gene id: 391623:TERMP_RS00330
uniprot id: F0LH84
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

391623:TERMP RS03300
gene id: 391623:TERMP_RS03300
uniprot id: F0LKR0
names: Similarity
messages: Belongs to the UPF0045 family.

391623:TERMP RS02370
gene id: 391623:TERMP_RS02370
uniprot id: F0LJI6
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

391623:TERMP RS03690
gene id: 391623:TERMP_RS03690
uniprot id: F0LL65
names: Cofactor
messages: Binds 1 zinc ion per subunit.

391623:TERMP RS11070
gene id: 391623:TERMP_RS11070
uniprot id: F0LN75
names: Similarity
messages: Belongs to the HsdR family.

391623:TERMP RS01390
gene id: 391623:TERMP_RS01390
uniprot id: F0LIH8
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

391623:TERMP RS10870
gene id: 391623:TERMP_RS10870
uniprot id: F0LME8
names: Similarity
messages: Belongs to the HupF/HypC family.

391623:TERMP RS08880
gene id: 391623:TERMP_RS08880
uniprot id: F0LK59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

391623:TERMP RS08035
gene id: 391623:TERMP_RS08035
uniprot id: F0LJ75
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

391623:TERMP RS04090
gene id: 391623:TERMP_RS04090
uniprot id: F0LLM0
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

391623:TERMP RS00460
gene id: 391623:TERMP_RS00460
uniprot id: F0LHB1
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

391623:TERMP RS09410
gene id: 391623:TERMP_RS09410
uniprot id: F0LKP2
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS08620
gene id: 391623:TERMP_RS08620
uniprot id: F0LJS6
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS08985
gene id: 391623:TERMP_RS08985
uniprot id: F0LK80
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

391623:TERMP RS07795
gene id: 391623:TERMP_RS07795
uniprot id: F0LIU6
names: Similarity
messages: Belongs to the class-I fumarase family.

391623:TERMP RS05000
gene id: 391623:TERMP_RS05000
uniprot id: F0LMJ9
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

391623:TERMP RS07415
gene id: 391623:TERMP_RS07415
uniprot id: F0LIE2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

391623:TERMP RS03425
gene id: 391623:TERMP_RS03425
uniprot id: F0LKT5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

391623:TERMP RS03635
gene id: 391623:TERMP_RS03635
uniprot id: F0LKX6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

391623:TERMP RS05530
gene id: 391623:TERMP_RS05530
uniprot id: F0LMV7
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

391623:TERMP RS04585
gene id: 391623:TERMP_RS04585
uniprot id: F0LM50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers.

391623:TERMP RS06385
gene id: 391623:TERMP_RS06385
uniprot id: F0LHD3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

391623:TERMP RS02010
gene id: 391623:TERMP_RS02010
uniprot id: F0LJ32
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

391623:TERMP RS05900
gene id: 391623:TERMP_RS05900
uniprot id: F0LN32
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

391623:TERMP RS08955
gene id: 391623:TERMP_RS08955
uniprot id: F0LK74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

391623:TERMP RS09580
gene id: 391623:TERMP_RS09580
uniprot id: F0LL05
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS09190
gene id: 391623:TERMP_RS09190
uniprot id: F0LKK0
names: Similarity
messages: Belongs to the UPF0310 family.

391623:TERMP RS07680
gene id: 391623:TERMP_RS07680
uniprot id: F0LIS3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

391623:TERMP RS03060
gene id: 391623:TERMP_RS03060
uniprot id: F0LKD3
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

391623:TERMP RS05430
gene id: 391623:TERMP_RS05430
uniprot id: F0LMT7
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

391623:TERMP RS02500
gene id: 391623:TERMP_RS02500
uniprot id: F0LJU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

391623:TERMP RS02815
gene id: 391623:TERMP_RS02815
uniprot id: F0LK07
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

391623:TERMP RS08185
gene id: 391623:TERMP_RS08185
uniprot id: F0LJA7
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

391623:TERMP RS06775
gene id: 391623:TERMP_RS06775
uniprot id: F0LHU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

391623:TERMP RS05645
gene id: 391623:TERMP_RS05645
uniprot id: F0LMX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

391623:TERMP RS02130
gene id: 391623:TERMP_RS02130
uniprot id: F0LJD7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

391623:TERMP RS01415
gene id: 391623:TERMP_RS01415
uniprot id: F0LII3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

391623:TERMP RS04595
gene id: 391623:TERMP_RS04595
uniprot id: F0LM52
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

391623:TERMP RS00555
gene id: 391623:TERMP_RS00555
uniprot id: F0LHK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

391623:TERMP RS02495
gene id: 391623:TERMP_RS02495
uniprot id: F0LJU2
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

391623:TERMP RS09405
gene id: 391623:TERMP_RS09405
uniprot id: F0LKP1
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS07460
gene id: 391623:TERMP_RS07460
uniprot id: F0LIF2
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS08390
gene id: 391623:TERMP_RS08390
uniprot id: F0LJM8
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

391623:TERMP RS10705
gene id: 391623:TERMP_RS10705
uniprot id: F0LMB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

391623:TERMP RS00965
gene id: 391623:TERMP_RS00965
uniprot id: F0LI21
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

391623:TERMP RS06325
gene id: 391623:TERMP_RS06325
uniprot id: F0LH42
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

391623:TERMP RS03025
gene id: 391623:TERMP_RS03025
uniprot id: F0LKC6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

391623:TERMP RS08400
gene id: 391623:TERMP_RS08400
uniprot id: F0LJN0
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

391623:TERMP RS02920
gene id: 391623:TERMP_RS02920
uniprot id: F0LKA6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

391623:TERMP RS02900
gene id: 391623:TERMP_RS02900
uniprot id: F0LKA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Forms a Heterooligomeric complex of two stacked eight-membered rings.
messages: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

391623:TERMP RS05560
gene id: 391623:TERMP_RS05560
uniprot id: F0LMW3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

391623:TERMP RS07920
gene id: 391623:TERMP_RS07920
uniprot id: F0LJ51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

391623:TERMP RS09040
gene id: 391623:TERMP_RS09040
uniprot id: F0LK92
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

391623:TERMP RS04825
gene id: 391623:TERMP_RS04825
uniprot id: F0LMG3
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

391623:TERMP RS05685
gene id: 391623:TERMP_RS05685
uniprot id: F0LMY7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

391623:TERMP RS00835
gene id: 391623:TERMP_RS00835
uniprot id: F0LHR3
names: Similarity
messages: Belongs to the UPF0440 family.

391623:TERMP RS03465
gene id: 391623:TERMP_RS03465
uniprot id: F0LKU3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

391623:TERMP RS00975
gene id: 391623:TERMP_RS00975
uniprot id: F0LI23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

391623:TERMP RS03815
gene id: 391623:TERMP_RS03815
uniprot id: F0LL88
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

391623:TERMP RS09985
gene id: 391623:TERMP_RS09985
uniprot id: F0LLF9
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

391623:TERMP RS04665
gene id: 391623:TERMP_RS04665
uniprot id: F0LM66
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

391623:TERMP RS03110
gene id: 391623:TERMP_RS03110
uniprot id: F0LKE2
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

391623:TERMP RS06985
gene id: 391623:TERMP_RS06985
uniprot id: F0LHY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

391623:TERMP RS00200
gene id: 391623:TERMP_RS00200
uniprot id: F0LH57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

391623:TERMP RS01505
gene id: 391623:TERMP_RS01505
uniprot id: F0LIK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm

391623:TERMP RS07615
gene id: 391623:TERMP_RS07615
uniprot id: F0LIR1
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

391623:TERMP RS09535
gene id: 391623:TERMP_RS09535
uniprot id: F0LKZ6
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

391623:TERMP RS10935
gene id: 391623:TERMP_RS10935
uniprot id: F0LMG1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

391623:TERMP RS00550
gene id: 391623:TERMP_RS00550
uniprot id: F0LHK7
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

391623:TERMP RS09280
gene id: 391623:TERMP_RS09280
uniprot id: F0LKL7
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

391623:TERMP RS06470
gene id: 391623:TERMP_RS06470
uniprot id: F0LHF1
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

391623:TERMP RS02125
gene id: 391623:TERMP_RS02125
uniprot id: F0LJD6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

391623:TERMP RS01885
gene id: 391623:TERMP_RS01885
uniprot id: F0LJ05
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

391623:TERMP RS00165
gene id: 391623:TERMP_RS00165
uniprot id: F0LH50
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS00825
gene id: 391623:TERMP_RS00825
uniprot id: F0LHR1
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

391623:TERMP RS10500
gene id: 391623:TERMP_RS10500
uniprot id: F0LLZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

391623:TERMP RS04610
gene id: 391623:TERMP_RS04610
uniprot id: F0LM55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

391623:TERMP RS06590
gene id: 391623:TERMP_RS06590
uniprot id: F0LHH5
names: Similarity
messages: Belongs to the UPF0282 family.

391623:TERMP RS08525
gene id: 391623:TERMP_RS08525
uniprot id: F0LJQ5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

391623:TERMP RS05785
gene id: 391623:TERMP_RS05785
uniprot id: F0LN07
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate kinase PfkC family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate using ADP as the phosphate donor.
messages: Cytoplasm

391623:TERMP RS06675
gene id: 391623:TERMP_RS06675
uniprot id: F0LHJ2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

391623:TERMP RS01925
gene id: 391623:TERMP_RS01925
uniprot id: F0LJ14
names: Similarity
messages: Belongs to the HepT RNase toxin family.

391623:TERMP RS05125
gene id: 391623:TERMP_RS05125
uniprot id: F0LMM4
names: Similarity
messages: Belongs to the band 7/mec-2 family.

391623:TERMP RS10070
gene id: 391623:TERMP_RS10070
uniprot id: F0LLH7
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

391623:TERMP RS09305
gene id: 391623:TERMP_RS09305
uniprot id: F0LKM2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

391623:TERMP RS08420
gene id: 391623:TERMP_RS08420
uniprot id: F0LJN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

391623:TERMP RS10095
gene id: 391623:TERMP_RS10095
uniprot id: F0LLI2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

391623:TERMP RS02175
gene id: 391623:TERMP_RS02175
uniprot id: F0LJE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

391623:TERMP RS06135
gene id: 391623:TERMP_RS06135
uniprot id: F0LGZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

391623:TERMP RS07975
gene id: 391623:TERMP_RS07975
uniprot id: F0LJ62
names: Similarity
messages: Belongs to the DtxR/MntR family.

391623:TERMP RS04850
gene id: 391623:TERMP_RS04850
uniprot id: F0LMG8
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

391623:TERMP RS08275
gene id: 391623:TERMP_RS08275
uniprot id: F0LJC5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

391623:TERMP RS01615
gene id: 391623:TERMP_RS01615
uniprot id: F0LIM2
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

391623:TERMP RS06375
gene id: 391623:TERMP_RS06375
uniprot id: F0LHD1
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

391623:TERMP RS02080
gene id: 391623:TERMP_RS02080
uniprot id: F0LJC7
names: Similarity
messages: Belongs to the aspartokinase family.

391623:TERMP RS07575
gene id: 391623:TERMP_RS07575
uniprot id: F0LIQ3
names: Similarity
messages: Belongs to the UPF0215 family.

391623:TERMP RS07110
gene id: 391623:TERMP_RS07110
uniprot id: F0LI10
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

391623:TERMP RS06400
gene id: 391623:TERMP_RS06400
uniprot id: F0LHD6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

391623:TERMP RS07840
gene id: 391623:TERMP_RS07840
uniprot id: F0LIV6
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS03710
gene id: 391623:TERMP_RS03710
uniprot id: F0LL69
names: Similarity
messages: Belongs to the peptidase U62 family.

391623:TERMP RS03230
gene id: 391623:TERMP_RS03230
uniprot id: F0LKG7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

391623:TERMP RS03750
gene id: 391623:TERMP_RS03750
uniprot id: F0LL75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

391623:TERMP RS07710
gene id: 391623:TERMP_RS07710
uniprot id: F0LIS9
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

391623:TERMP RS05940
gene id: 391623:TERMP_RS05940
uniprot id: F0LN40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

391623:TERMP RS07660
gene id: 391623:TERMP_RS07660
uniprot id: F0LIR9
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS00660
gene id: 391623:TERMP_RS00660
uniprot id: F0LHM8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

391623:TERMP RS02070
gene id: 391623:TERMP_RS02070
uniprot id: F0LJ45
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

391623:TERMP RS08605
gene id: 391623:TERMP_RS08605
uniprot id: F0LJS2
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS07885
gene id: 391623:TERMP_RS07885
uniprot id: F0LIW4
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

391623:TERMP RS04775
gene id: 391623:TERMP_RS04775
uniprot id: F0LM85
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

391623:TERMP RS05640
gene id: 391623:TERMP_RS05640
uniprot id: F0LMX8
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS07520
gene id: 391623:TERMP_RS07520
uniprot id: F0LIP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

391623:TERMP RS01470
gene id: 391623:TERMP_RS01470
uniprot id: F0LIJ4
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS00710
gene id: 391623:TERMP_RS00710
uniprot id: F0LHN7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

391623:TERMP RS09210
gene id: 391623:TERMP_RS09210
uniprot id: F0LKK4
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

391623:TERMP RS09460
gene id: 391623:TERMP_RS09460
uniprot id: F0LKX9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

391623:TERMP RS00720
gene id: 391623:TERMP_RS00720
uniprot id: F0LHN9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

391623:TERMP RS03470
gene id: 391623:TERMP_RS03470
uniprot id: F0LKU4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

391623:TERMP RS08040
gene id: 391623:TERMP_RS08040
uniprot id: F0LJ76
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

391623:TERMP RS01785
gene id: 391623:TERMP_RS01785
uniprot id: F0LIY5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

391623:TERMP RS03100
gene id: 391623:TERMP_RS03100
uniprot id: F0LKE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

391623:TERMP RS05465
gene id: 391623:TERMP_RS05465
uniprot id: F0LMU4
names: Similarity
messages: Belongs to the PDCD5 family.

391623:TERMP RS02925
gene id: 391623:TERMP_RS02925
uniprot id: F0LKA7
names: Similarity
messages: Belongs to the UPF0145 family.

391623:TERMP RS08485
gene id: 391623:TERMP_RS08485
uniprot id: F0LJP7
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

391623:TERMP RS00375
gene id: 391623:TERMP_RS00375
uniprot id: F0LH93
names: Subcellular Location Annotation
messages: Nucleus

391623:TERMP RS03740
gene id: 391623:TERMP_RS03740
uniprot id: F0LL73
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

391623:TERMP RS07720
gene id: 391623:TERMP_RS07720
uniprot id: F0LIT1
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

391623:TERMP RS00015
gene id: 391623:TERMP_RS00015
uniprot id: F0LGU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

391623:TERMP RS01460
gene id: 391623:TERMP_RS01460
uniprot id: F0LIJ2
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

391623:TERMP RS07875
gene id: 391623:TERMP_RS07875
uniprot id: F0LIW2
names: Similarity
messages: Belongs to the HsdR family.

391623:TERMP RS02030
gene id: 391623:TERMP_RS02030
uniprot id: F0LJ36
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

391623:TERMP RS01545
gene id: 391623:TERMP_RS01545
uniprot id: F0LIK9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

391623:TERMP RS00405
gene id: 391623:TERMP_RS00405
uniprot id: F0LH99
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

391623:TERMP RS11220
gene id: 391623:TERMP_RS11220
uniprot id: F0LNA4
names: Similarity
messages: Belongs to the UPF0310 family.

391623:TERMP RS09615
gene id: 391623:TERMP_RS09615
uniprot id: F0LL12
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

391623:TERMP RS01225
gene id: 391623:TERMP_RS01225
uniprot id: F0LI68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

391623:TERMP RS07025
gene id: 391623:TERMP_RS07025
uniprot id: F0LHZ3
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

391623:TERMP RS05675
gene id: 391623:TERMP_RS05675
uniprot id: F0LMY5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

391623:TERMP RS10160
gene id: 391623:TERMP_RS10160
uniprot id: F0LLJ6
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

391623:TERMP RS02335
gene id: 391623:TERMP_RS02335
uniprot id: F0LJH9
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

391623:TERMP RS04355
gene id: 391623:TERMP_RS04355
uniprot id: F0LLS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

391623:TERMP RS05660
gene id: 391623:TERMP_RS05660
uniprot id: F0LMY2
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

391623:TERMP RS07585
gene id: 391623:TERMP_RS07585
uniprot id: F0LIQ5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

391623:TERMP RS01550
gene id: 391623:TERMP_RS01550
uniprot id: F0LIL0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

391623:TERMP RS04285
gene id: 391623:TERMP_RS04285
uniprot id: F0LLR0
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS03440
gene id: 391623:TERMP_RS03440
uniprot id: F0LKT8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M54 family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.
messages: Monomer.
messages: Probable zinc metalloprotease whose natural substrate is unknown.

391623:TERMP RS00440
gene id: 391623:TERMP_RS00440
uniprot id: F0LHA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

391623:TERMP RS00785
gene id: 391623:TERMP_RS00785
uniprot id: F0LHQ3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

391623:TERMP RS07405
gene id: 391623:TERMP_RS07405
uniprot id: F0LIE0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

391623:TERMP RS07475
gene id: 391623:TERMP_RS07475
uniprot id: F0LIF5
names: Similarity
messages: Belongs to the UPF0200 family.

391623:TERMP RS00255
gene id: 391623:TERMP_RS00255
uniprot id: F0LH69
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

391623:TERMP RS02255
gene id: 391623:TERMP_RS02255
uniprot id: F0LJG2
names: Function
names: Similarity
messages: Belongs to the 2-phosphoglycerate kinase family.
messages: Catalyzes the phosphorylation of 2-phosphoglycerate to 2,3-diphosphoglycerate. Involved in the biosynthesis of cyclic 2,3-bisphosphoglycerate, a thermoprotectant.

391623:TERMP RS07535
gene id: 391623:TERMP_RS07535
uniprot id: F0LIP5
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

391623:TERMP RS06540
gene id: 391623:TERMP_RS06540
uniprot id: F0LHG5
names: Similarity
messages: Belongs to the UPF0173 family.

391623:TERMP RS08340
gene id: 391623:TERMP_RS08340
uniprot id: F0LJL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

391623:TERMP RS02105
gene id: 391623:TERMP_RS02105
uniprot id: F0LJD2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm

391623:TERMP RS07705
gene id: 391623:TERMP_RS07705
uniprot id: F0LIS8
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

391623:TERMP RS05360
gene id: 391623:TERMP_RS05360
uniprot id: F0LMS2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

391623:TERMP RS04365
gene id: 391623:TERMP_RS04365
uniprot id: F0LLS5
names: Subunit
messages: Homotetramer.

391623:TERMP RS02270
gene id: 391623:TERMP_RS02270
uniprot id: F0LJG5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

391623:TERMP RS09975
gene id: 391623:TERMP_RS09975
uniprot id: F0LLF7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

391623:TERMP RS07725
gene id: 391623:TERMP_RS07725
uniprot id: F0LIT2
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

391623:TERMP RS00520
gene id: 391623:TERMP_RS00520
uniprot id: F0LHC3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

391623:TERMP RS02035
gene id: 391623:TERMP_RS02035
uniprot id: F0LJ37
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

391623:TERMP RS05190
gene id: 391623:TERMP_RS05190
uniprot id: F0LMN7
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

391623:TERMP RS01000
gene id: 391623:TERMP_RS01000
uniprot id: F0LI29
names: Similarity
messages: Belongs to the phosphohexose mutase family.

391623:TERMP RS02830
gene id: 391623:TERMP_RS02830
uniprot id: F0LK10
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

391623:TERMP RS00790
gene id: 391623:TERMP_RS00790
uniprot id: F0LHQ4
names: Similarity
messages: Belongs to the SDO1/SBDS family.

391623:TERMP RS01230
gene id: 391623:TERMP_RS01230
uniprot id: F0LI69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

391623:TERMP RS02455
gene id: 391623:TERMP_RS02455
uniprot id: F0LJK4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

391623:TERMP RS01145
gene id: 391623:TERMP_RS01145
uniprot id: F0LI57
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

391623:TERMP RS02350
gene id: 391623:TERMP_RS02350
uniprot id: F0LJI2
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

391623:TERMP RS05275
gene id: 391623:TERMP_RS05275
uniprot id: F0LMQ4
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

391623:TERMP RS07630
gene id: 391623:TERMP_RS07630
uniprot id: F0LIR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

391623:TERMP RS01220
gene id: 391623:TERMP_RS01220
uniprot id: F0LI67
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

391623:TERMP RS09470
gene id: 391623:TERMP_RS09470
uniprot id: F0LKY1
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

391623:TERMP RS00450
gene id: 391623:TERMP_RS00450
uniprot id: F0LHA9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

391623:TERMP RS07505
gene id: 391623:TERMP_RS07505
uniprot id: F0LIN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

391623:TERMP RS03540
gene id: 391623:TERMP_RS03540
uniprot id: F0LKV7
names: Similarity
messages: Belongs to the UPF0212 family.

391623:TERMP RS03315
gene id: 391623:TERMP_RS03315
uniprot id: F0LKR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

391623:TERMP RS02375
gene id: 391623:TERMP_RS02375
uniprot id: F0LJI7
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas5 family. Subtype I-A/Apern subfamily.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

391623:TERMP RS02755
gene id: 391623:TERMP_RS02755
uniprot id: F0LJZ5
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

391623:TERMP RS06515
gene id: 391623:TERMP_RS06515
uniprot id: F0LHG0
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

391623:TERMP RS04065
gene id: 391623:TERMP_RS04065
uniprot id: F0LLL5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

391623:TERMP RS08495
gene id: 391623:TERMP_RS08495
uniprot id: F0LJP8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

391623:TERMP RS09920
gene id: 391623:TERMP_RS09920
uniprot id: F0LLE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

391623:TERMP RS02545
gene id: 391623:TERMP_RS02545
uniprot id: F0LJV2
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS04760
gene id: 391623:TERMP_RS04760
uniprot id: F0LM82
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS00195
gene id: 391623:TERMP_RS00195
uniprot id: F0LH56
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS03320
gene id: 391623:TERMP_RS03320
uniprot id: F0LKR4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

391623:TERMP RS02275
gene id: 391623:TERMP_RS02275
uniprot id: F0LJG6
names: Similarity
messages: Belongs to the CinA family.

391623:TERMP RS08860
gene id: 391623:TERMP_RS08860
uniprot id: F0LK55
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

391623:TERMP RS07205
gene id: 391623:TERMP_RS07205
uniprot id: F0LIA0
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

391623:TERMP RS08385
gene id: 391623:TERMP_RS08385
uniprot id: F0LJM7
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

391623:TERMP RS00830
gene id: 391623:TERMP_RS00830
uniprot id: F0LHR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

391623:TERMP RS07645
gene id: 391623:TERMP_RS07645
uniprot id: F0LIR7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

391623:TERMP RS04570
gene id: 391623:TERMP_RS04570
uniprot id: F0LM46
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

391623:TERMP RS10760
gene id: 391623:TERMP_RS10760
uniprot id: F0LMC5
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

391623:TERMP RS05580
gene id: 391623:TERMP_RS05580
uniprot id: F0LMW6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

391623:TERMP RS00815
gene id: 391623:TERMP_RS00815
uniprot id: F0LHQ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

391623:TERMP RS03010
gene id: 391623:TERMP_RS03010
uniprot id: F0LKC3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

391623:TERMP RS10865
gene id: 391623:TERMP_RS10865
uniprot id: F0LME7
names: Similarity
messages: Belongs to the HypD family.

391623:TERMP RS04910
gene id: 391623:TERMP_RS04910
uniprot id: F0LMI1
names: Similarity
messages: Belongs to the peptidase C56 family.

391623:TERMP RS03460
gene id: 391623:TERMP_RS03460
uniprot id: F0LKU2
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS03625
gene id: 391623:TERMP_RS03625
uniprot id: F0LKX4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

391623:TERMP RS00925
gene id: 391623:TERMP_RS00925
uniprot id: F0LI13
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

391623:TERMP RS06560
gene id: 391623:TERMP_RS06560
uniprot id: F0LHG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

391623:TERMP RS07360
gene id: 391623:TERMP_RS07360
uniprot id: F0LID1
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS07255
gene id: 391623:TERMP_RS07255
uniprot id: F0LIB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S16 family.
messages: Membrane

391623:TERMP RS04755
gene id: 391623:TERMP_RS04755
uniprot id: F0LM81
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

391623:TERMP RS06410
gene id: 391623:TERMP_RS06410
uniprot id: F0LHD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

391623:TERMP RS00670
gene id: 391623:TERMP_RS00670
uniprot id: F0LHM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

391623:TERMP RS04440
gene id: 391623:TERMP_RS04440
uniprot id: F0LM21
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS07345
gene id: 391623:TERMP_RS07345
uniprot id: F0LIC8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

391623:TERMP RS08940
gene id: 391623:TERMP_RS08940
uniprot id: F0LK71
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS05585
gene id: 391623:TERMP_RS05585
uniprot id: F0LMW7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

391623:TERMP RS04830
gene id: 391623:TERMP_RS04830
uniprot id: F0LMG4
names: Similarity
messages: Belongs to the glycosyl hydrolase 4 family.

391623:TERMP RS00020
gene id: 391623:TERMP_RS00020
uniprot id: F0LGU2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal-type GPI family.
messages: Cytoplasm
messages: Homodimer.

391623:TERMP RS10905
gene id: 391623:TERMP_RS10905
uniprot id: F0LMF5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

391623:TERMP RS08020
gene id: 391623:TERMP_RS08020
uniprot id: F0LJ72
names: Similarity
messages: Belongs to the UPF0045 family.

391623:TERMP RS04765
gene id: 391623:TERMP_RS04765
uniprot id: F0LM83
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

391623:TERMP RS02060
gene id: 391623:TERMP_RS02060
uniprot id: F0LJ43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

391623:TERMP RS10490
gene id: 391623:TERMP_RS10490
uniprot id: F0LLZ4
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS08910
gene id: 391623:TERMP_RS08910
uniprot id: F0LK65
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

391623:TERMP RS02390
gene id: 391623:TERMP_RS02390
uniprot id: F0LJJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

391623:TERMP RS00750
gene id: 391623:TERMP_RS00750
uniprot id: F0LHP5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

391623:TERMP RS03275
gene id: 391623:TERMP_RS03275
uniprot id: F0LKQ5
names: Similarity
messages: Belongs to the glutaredoxin family.

391623:TERMP RS04555
gene id: 391623:TERMP_RS04555
uniprot id: F0LM43
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

391623:TERMP RS01600
gene id: 391623:TERMP_RS01600
uniprot id: F0LIL9
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS08640
gene id: 391623:TERMP_RS08640
uniprot id: F0LJT0
names: Similarity
messages: Belongs to the peptidase S9C family.

391623:TERMP RS03645
gene id: 391623:TERMP_RS03645
uniprot id: F0LKX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

391623:TERMP RS09270
gene id: 391623:TERMP_RS09270
uniprot id: F0LKL5
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

391623:TERMP RS10575
gene id: 391623:TERMP_RS10575
uniprot id: F0LM11
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

391623:TERMP RS00155
gene id: 391623:TERMP_RS00155
uniprot id: F0LH48
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS05425
gene id: 391623:TERMP_RS05425
uniprot id: F0LMT6
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

391623:TERMP RS03280
gene id: 391623:TERMP_RS03280
uniprot id: F0LKQ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

391623:TERMP RS05030
gene id: 391623:TERMP_RS05030
uniprot id: F0LMK4
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

391623:TERMP RS00230
gene id: 391623:TERMP_RS00230
uniprot id: F0LH63
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

391623:TERMP RS08440
gene id: 391623:TERMP_RS08440
uniprot id: F0LJN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

391623:TERMP RS02490
gene id: 391623:TERMP_RS02490
uniprot id: F0LJU1
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

391623:TERMP RS03370
gene id: 391623:TERMP_RS03370
uniprot id: F0LKS5
names: Similarity
messages: Belongs to the IMPACT family.

391623:TERMP RS03130
gene id: 391623:TERMP_RS03130
uniprot id: F0LKE6
names: Similarity
messages: Belongs to the HepT RNase toxin family.

391623:TERMP RS00150
gene id: 391623:TERMP_RS00150
uniprot id: F0LH47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

391623:TERMP RS04645
gene id: 391623:TERMP_RS04645
uniprot id: F0LM62
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

391623:TERMP RS02705
gene id: 391623:TERMP_RS02705
uniprot id: F0LJY5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

391623:TERMP RS03005
gene id: 391623:TERMP_RS03005
uniprot id: F0LKC2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

391623:TERMP RS04335
gene id: 391623:TERMP_RS04335
uniprot id: F0LLR9
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

391623:TERMP RS07035
gene id: 391623:TERMP_RS07035
uniprot id: F0LHZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

391623:TERMP RS07955
gene id: 391623:TERMP_RS07955
uniprot id: F0LJ58
names: Similarity
messages: Belongs to the LDH2/MDH2 oxidoreductase family.

391623:TERMP RS06080
gene id: 391623:TERMP_RS06080
uniprot id: F0LGY8
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS08320
gene id: 391623:TERMP_RS08320
uniprot id: F0LJL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

391623:TERMP RS00675
gene id: 391623:TERMP_RS00675
uniprot id: F0LHN0
names: Similarity
messages: Belongs to the enolase family.

391623:TERMP RS02515
gene id: 391623:TERMP_RS02515
uniprot id: F0LJU6
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

391623:TERMP RS06530
gene id: 391623:TERMP_RS06530
uniprot id: F0LHG3
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

391623:TERMP RS09300
gene id: 391623:TERMP_RS09300
uniprot id: F0LKM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.

391623:TERMP RS00770
gene id: 391623:TERMP_RS00770
uniprot id: F0LHP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

391623:TERMP RS04105
gene id: 391623:TERMP_RS04105
uniprot id: F0LLM3
names: Similarity
messages: Belongs to the RuvB family.

391623:TERMP RS00190
gene id: 391623:TERMP_RS00190
uniprot id: F0LH55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

391623:TERMP RS02480
gene id: 391623:TERMP_RS02480
uniprot id: F0LJT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

391623:TERMP RS02160
gene id: 391623:TERMP_RS02160
uniprot id: F0LJE3
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

391623:TERMP RS00940
gene id: 391623:TERMP_RS00940
uniprot id: F0LI16
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

391623:TERMP RS10785
gene id: 391623:TERMP_RS10785
uniprot id: F0LMD0
names: Similarity
messages: Belongs to the peptidase S8 family.

391623:TERMP RS01050
gene id: 391623:TERMP_RS01050
uniprot id: F0LI39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

391623:TERMP RS01165
gene id: 391623:TERMP_RS01165
uniprot id: F0LI61
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

391623:TERMP RS09980
gene id: 391623:TERMP_RS09980
uniprot id: F0LLF8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

391623:TERMP RS09940
gene id: 391623:TERMP_RS09940
uniprot id: F0LLF0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

391623:TERMP RS06700
gene id: 391623:TERMP_RS06700
uniprot id: F0LHJ7
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS10075
gene id: 391623:TERMP_RS10075
uniprot id: F0LLH8
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

391623:TERMP RS03745
gene id: 391623:TERMP_RS03745
uniprot id: F0LL74
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

391623:TERMP RS07960
gene id: 391623:TERMP_RS07960
uniprot id: F0LJ59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

391623:TERMP RS06460
gene id: 391623:TERMP_RS06460
uniprot id: F0LHE9
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

391623:TERMP RS09480
gene id: 391623:TERMP_RS09480
uniprot id: F0LKY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Homotetramer.
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

391623:TERMP RS08920
gene id: 391623:TERMP_RS08920
uniprot id: F0LK67
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs.

391623:TERMP RS03495
gene id: 391623:TERMP_RS03495
uniprot id: F0LKU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
messages: Cell membrane
messages: Membrane

391623:TERMP RS10105
gene id: 391623:TERMP_RS10105
uniprot id: F0LLI4
names: Similarity
messages: Belongs to the GARS family.

391623:TERMP RS02845
gene id: 391623:TERMP_RS02845
uniprot id: F0LK13
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

391623:TERMP RS04405
gene id: 391623:TERMP_RS04405
uniprot id: F0LLT4
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS00605
gene id: 391623:TERMP_RS00605
uniprot id: F0LHL8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

391623:TERMP RS00935
gene id: 391623:TERMP_RS00935
uniprot id: F0LI15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

391623:TERMP RS09085
gene id: 391623:TERMP_RS09085
uniprot id: F0LKH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

391623:TERMP RS02290
gene id: 391623:TERMP_RS02290
uniprot id: F0LJG9
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

391623:TERMP RS03290
gene id: 391623:TERMP_RS03290
uniprot id: F0LKQ8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

391623:TERMP RS00125
gene id: 391623:TERMP_RS00125
uniprot id: F0LGW4
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

391623:TERMP RS10135
gene id: 391623:TERMP_RS10135
uniprot id: F0LLJ0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

391623:TERMP RS10900
gene id: 391623:TERMP_RS10900
uniprot id: F0LMF4
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

391623:TERMP RS01620
gene id: 391623:TERMP_RS01620
uniprot id: F0LIM3
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

391623:TERMP RS02180
gene id: 391623:TERMP_RS02180
uniprot id: F0LJE7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

391623:TERMP RS05310
gene id: 391623:TERMP_RS05310
uniprot id: F0LMR2
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

391623:TERMP RS02305
gene id: 391623:TERMP_RS02305
uniprot id: F0LJH2
names: Similarity
messages: Belongs to the UPF0166 family.

391623:TERMP RS04390
gene id: 391623:TERMP_RS04390
uniprot id: F0LLT1
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

391623:TERMP RS08480
gene id: 391623:TERMP_RS08480
uniprot id: F0LJP6
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

391623:TERMP RS00705
gene id: 391623:TERMP_RS00705
uniprot id: F0LHN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

391623:TERMP RS10060
gene id: 391623:TERMP_RS10060
uniprot id: F0LLH5
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

391623:TERMP RS03960
gene id: 391623:TERMP_RS03960
uniprot id: F0LLC0
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

391623:TERMP RS03630
gene id: 391623:TERMP_RS03630
uniprot id: F0LKX5
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

391623:TERMP RS03070
gene id: 391623:TERMP_RS03070
uniprot id: F0LKD5
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

391623:TERMP RS00955
gene id: 391623:TERMP_RS00955
uniprot id: F0LI19
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

391623:TERMP RS04490
gene id: 391623:TERMP_RS04490
uniprot id: F0LM30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

391623:TERMP RS02425
gene id: 391623:TERMP_RS02425
uniprot id: F0LJJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

391623:TERMP RS04525
gene id: 391623:TERMP_RS04525
uniprot id: F0LM37
names: Similarity
messages: Belongs to the RutC family.

391623:TERMP RS05920
gene id: 391623:TERMP_RS05920
uniprot id: F0LN36
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS08520
gene id: 391623:TERMP_RS08520
uniprot id: F0LJQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

391623:TERMP RS09960
gene id: 391623:TERMP_RS09960
uniprot id: F0LLF4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

391623:TERMP RS06350
gene id: 391623:TERMP_RS06350
uniprot id: F0LHC6
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

391623:TERMP RS06130
gene id: 391623:TERMP_RS06130
uniprot id: F0LGZ8
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

391623:TERMP RS01485
gene id: 391623:TERMP_RS01485
uniprot id: F0LIJ7
names: Similarity
messages: Belongs to the UPF0175 family.

391623:TERMP RS01215
gene id: 391623:TERMP_RS01215
uniprot id: F0LI66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

391623:TERMP RS05650
gene id: 391623:TERMP_RS05650
uniprot id: F0LMY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

391623:TERMP RS05540
gene id: 391623:TERMP_RS05540
uniprot id: F0LMV9
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

391623:TERMP RS07970
gene id: 391623:TERMP_RS07970
uniprot id: F0LJ61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

391623:TERMP RS04640
gene id: 391623:TERMP_RS04640
uniprot id: F0LM61
names: Function
names: Similarity
messages: Belongs to the FAU-1 family.
messages: Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.

391623:TERMP RS05695
gene id: 391623:TERMP_RS05695
uniprot id: F0LMY9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

391623:TERMP RS07390
gene id: 391623:TERMP_RS07390
uniprot id: F0LID7
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS06770
gene id: 391623:TERMP_RS06770
uniprot id: F0LHT9
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

391623:TERMP RS01515
gene id: 391623:TERMP_RS01515
uniprot id: F0LIK3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

391623:TERMP RS08775
gene id: 391623:TERMP_RS08775
uniprot id: F0LK38
names: Similarity
messages: Belongs to the UPF0111 family.

391623:TERMP RS00920
gene id: 391623:TERMP_RS00920
uniprot id: F0LI12
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

391623:TERMP RS03175
gene id: 391623:TERMP_RS03175
uniprot id: F0LKF6
names: Similarity
messages: Belongs to the UPF0248 family.

391623:TERMP RS09320
gene id: 391623:TERMP_RS09320
uniprot id: F0LKM4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

391623:TERMP RS07665
gene id: 391623:TERMP_RS07665
uniprot id: F0LIS0
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS03785
gene id: 391623:TERMP_RS03785
uniprot id: F0LL82
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.
messages: Catalyzes the dephosphorylation of D,L-glyceraldehyde 3-phosphate in vitro.

391623:TERMP RS08120
gene id: 391623:TERMP_RS08120
uniprot id: F0LJ93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

391623:TERMP RS08415
gene id: 391623:TERMP_RS08415
uniprot id: F0LJN3
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS02435
gene id: 391623:TERMP_RS02435
uniprot id: F0LJK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

391623:TERMP RS10080
gene id: 391623:TERMP_RS10080
uniprot id: F0LLH9
names: Similarity
messages: Belongs to the SAICAR synthetase family.

391623:TERMP RS02520
gene id: 391623:TERMP_RS02520
uniprot id: F0LJU7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

391623:TERMP RS00775
gene id: 391623:TERMP_RS00775
uniprot id: F0LHQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

391623:TERMP RS05635
gene id: 391623:TERMP_RS05635
uniprot id: F0LMX7
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the C-terminal section; belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: In the N-terminal section; belongs to the MobA family.

391623:TERMP RS10565
gene id: 391623:TERMP_RS10565
uniprot id: F0LM09
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

391623:TERMP RS10115
gene id: 391623:TERMP_RS10115
uniprot id: F0LLI6
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS07180
gene id: 391623:TERMP_RS07180
uniprot id: F0LI95
names: Similarity
messages: Belongs to the BtpA family.

391623:TERMP RS08405
gene id: 391623:TERMP_RS08405
uniprot id: F0LJN1
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

391623:TERMP RS01935
gene id: 391623:TERMP_RS01935
uniprot id: F0LJ17
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

391623:TERMP RS05175
gene id: 391623:TERMP_RS05175
uniprot id: F0LMN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

391623:TERMP RS01565
gene id: 391623:TERMP_RS01565
uniprot id: F0LIL3
names: Function
names: Similarity
messages: Belongs to the UPF0330 family.
messages: Possibly the antitoxin component of a toxin-antitoxin (TA) module.

391623:TERMP RS08410
gene id: 391623:TERMP_RS08410
uniprot id: F0LJN2
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

391623:TERMP RS10015
gene id: 391623:TERMP_RS10015
uniprot id: F0LLG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

391623:TERMP RS06895
gene id: 391623:TERMP_RS06895
uniprot id: F0LHW6
names: Similarity
messages: Belongs to the AAA ATPase family.

391623:TERMP RS02210
gene id: 391623:TERMP_RS02210
uniprot id: F0LJF3
names: Caution
names: Domain
names: Function
names: Similarity
messages: Belongs to the archaeal N-glycosylase/DNA lyase (AGOG) family.
messages: Contains two alpha-helical subdomains, with the 8-oxoguanine binding site located in a cleft at their interface. Contains a helix-hairpin-helix (HhH) structural motif and a Gly/Pro-rich sequence followed by a conserved Asp (HhH-GPD motif).
messages: DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

391623:TERMP RS06005
gene id: 391623:TERMP_RS06005
uniprot id: F0LGX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

391623:TERMP RS03655
gene id: 391623:TERMP_RS03655
uniprot id: F0LL58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

391623:TERMP RS03490
gene id: 391623:TERMP_RS03490
uniprot id: F0LKU7
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

391623:TERMP RS04305
gene id: 391623:TERMP_RS04305
uniprot id: F0LLR4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

391623:TERMP RS06655
gene id: 391623:TERMP_RS06655
uniprot id: F0LHI8
names: Subcellular Location Annotation
messages: Cell membrane

391623:TERMP RS01495
gene id: 391623:TERMP_RS01495
uniprot id: F0LIJ9
names: Similarity
messages: Belongs to the UPF0235 family.

391623:TERMP RS05005
gene id: 391623:TERMP_RS05005
uniprot id: F0LMK0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

391623:TERMP RS00655
gene id: 391623:TERMP_RS00655
uniprot id: F0LHM7
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

391623:TERMP RS05890
gene id: 391623:TERMP_RS05890
uniprot id: F0LN30
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS08210
gene id: 391623:TERMP_RS08210
uniprot id: F0LJB2
names: Similarity
messages: Belongs to the UPF0146 family.

391623:TERMP RS04430
gene id: 391623:TERMP_RS04430
uniprot id: F0LM19
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS02110
gene id: 391623:TERMP_RS02110
uniprot id: F0LJD3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

391623:TERMP RS04480
gene id: 391623:TERMP_RS04480
uniprot id: F0LM28
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

391623:TERMP RS00630
gene id: 391623:TERMP_RS00630
uniprot id: F0LHM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

391623:TERMP RS03970
gene id: 391623:TERMP_RS03970
uniprot id: F0LLC2
names: Subunit
messages: Homodimer.

391623:TERMP RS01235
gene id: 391623:TERMP_RS01235
uniprot id: F0LI70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

391623:TERMP RS08280
gene id: 391623:TERMP_RS08280
uniprot id: F0LJC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

391623:TERMP RS05925
gene id: 391623:TERMP_RS05925
uniprot id: F0LN37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

391623:TERMP RS09090
gene id: 391623:TERMP_RS09090
uniprot id: F0LKH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

391623:TERMP RS08505
gene id: 391623:TERMP_RS08505
uniprot id: F0LJQ0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

391623:TERMP RS04790
gene id: 391623:TERMP_RS04790
uniprot id: F0LM88
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

391623:TERMP RS00505
gene id: 391623:TERMP_RS00505
uniprot id: F0LHC0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

391623:TERMP RS04815
gene id: 391623:TERMP_RS04815
uniprot id: F0LM93
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.

391623:TERMP RS07865
gene id: 391623:TERMP_RS07865
uniprot id: F0LIW0
names: Similarity
messages: Belongs to the UPF0310 family.

391623:TERMP RS04605
gene id: 391623:TERMP_RS04605
uniprot id: F0LM54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

391623:TERMP RS10145
gene id: 391623:TERMP_RS10145
uniprot id: F0LLJ3
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

391623:TERMP RS00510
gene id: 391623:TERMP_RS00510
uniprot id: F0LHC1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

391623:TERMP RS05210
gene id: 391623:TERMP_RS05210
uniprot id: F0LMP1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

391623:TERMP RS06525
gene id: 391623:TERMP_RS06525
uniprot id: F0LHG2
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

391623:TERMP RS07500
gene id: 391623:TERMP_RS07500
uniprot id: F0LIG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

391623:TERMP RS02855
gene id: 391623:TERMP_RS02855
uniprot id: F0LK15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

391623:TERMP RS03720
gene id: 391623:TERMP_RS03720
uniprot id: F0LL71
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

391623:TERMP RS10025
gene id: 391623:TERMP_RS10025
uniprot id: F0LLG8
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS01245
gene id: 391623:TERMP_RS01245
uniprot id: F0LI72
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

391623:TERMP RS05485
gene id: 391623:TERMP_RS05485
uniprot id: F0LMU8
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS08045
gene id: 391623:TERMP_RS08045
uniprot id: F0LJ77
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

391623:TERMP RS03045
gene id: 391623:TERMP_RS03045
uniprot id: F0LKD0
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

391623:TERMP RS03415
gene id: 391623:TERMP_RS03415
uniprot id: F0LKT3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

391623:TERMP RS00805
gene id: 391623:TERMP_RS00805
uniprot id: F0LHQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

391623:TERMP RS01410
gene id: 391623:TERMP_RS01410
uniprot id: F0LII2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

391623:TERMP RS02840
gene id: 391623:TERMP_RS02840
uniprot id: F0LK12
names: Caution
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

391623:TERMP RS06465
gene id: 391623:TERMP_RS06465
uniprot id: F0LHF0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

391623:TERMP RS05730
gene id: 391623:TERMP_RS05730
uniprot id: F0LMZ6
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS09655
gene id: 391623:TERMP_RS09655
uniprot id: F0LL19
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

391623:TERMP RS07225
gene id: 391623:TERMP_RS07225
uniprot id: F0LIA4
names: Similarity
messages: Belongs to the peptidase U62 family.

391623:TERMP RS07290
gene id: 391623:TERMP_RS07290
uniprot id: F0LIB7
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS01970
gene id: 391623:TERMP_RS01970
uniprot id: F0LJ24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

391623:TERMP RS08200
gene id: 391623:TERMP_RS08200
uniprot id: F0LJB0
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

391623:TERMP RS01915
gene id: 391623:TERMP_RS01915
uniprot id: F0LJ12
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

391623:TERMP RS04085
gene id: 391623:TERMP_RS04085
uniprot id: F0LLL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

391623:TERMP RS10795
gene id: 391623:TERMP_RS10795
uniprot id: F0LMD2
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS04055
gene id: 391623:TERMP_RS04055
uniprot id: F0LLL3
names: Similarity
messages: Belongs to the UPF0128 family.

391623:TERMP RS08195
gene id: 391623:TERMP_RS08195
uniprot id: F0LJA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

391623:TERMP RS02440
gene id: 391623:TERMP_RS02440
uniprot id: F0LJK1
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

391623:TERMP RS04310
gene id: 391623:TERMP_RS04310
uniprot id: F0LLR5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

391623:TERMP RS00385
gene id: 391623:TERMP_RS00385
uniprot id: F0LH95
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

391623:TERMP RS00950
gene id: 391623:TERMP_RS00950
uniprot id: F0LI18
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

391623:TERMP RS02475
gene id: 391623:TERMP_RS02475
uniprot id: F0LJT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

391623:TERMP RS08430
gene id: 391623:TERMP_RS08430
uniprot id: F0LJN6
names: Function
messages: Part of a potassium transport system.

391623:TERMP RS04080
gene id: 391623:TERMP_RS04080
uniprot id: F0LLL8
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

391623:TERMP RS02115
gene id: 391623:TERMP_RS02115
uniprot id: F0LJD4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

391623:TERMP RS01210
gene id: 391623:TERMP_RS01210
uniprot id: F0LI65
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

391623:TERMP RS09950
gene id: 391623:TERMP_RS09950
uniprot id: F0LLF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

391623:TERMP RS01660
gene id: 391623:TERMP_RS01660
uniprot id: F0LIN1
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

391623:TERMP RS00260
gene id: 391623:TERMP_RS00260
uniprot id: F0LH70
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

391623:TERMP RS05280
gene id: 391623:TERMP_RS05280
uniprot id: F0LMQ5
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

391623:TERMP RS09080
gene id: 391623:TERMP_RS09080
uniprot id: F0LKH7
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS08915
gene id: 391623:TERMP_RS08915
uniprot id: F0LK66
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS00565
gene id: 391623:TERMP_RS00565
uniprot id: F0LHL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

391623:TERMP RS01980
gene id: 391623:TERMP_RS01980
uniprot id: F0LJ26
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

391623:TERMP RS03685
gene id: 391623:TERMP_RS03685
uniprot id: F0LL64
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

391623:TERMP RS03120
gene id: 391623:TERMP_RS03120
uniprot id: F0LKE4
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

391623:TERMP RS01540
gene id: 391623:TERMP_RS01540
uniprot id: F0LIK8
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS09200
gene id: 391623:TERMP_RS09200
uniprot id: F0LKK2
names: Similarity
messages: Belongs to the HerA family.

391623:TERMP RS00185
gene id: 391623:TERMP_RS00185
uniprot id: F0LH54
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

391623:TERMP RS05185
gene id: 391623:TERMP_RS05185
uniprot id: F0LMN6
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

391623:TERMP RS04705
gene id: 391623:TERMP_RS04705
uniprot id: F0LM71
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

391623:TERMP RS09675
gene id: 391623:TERMP_RS09675
uniprot id: F0LL23
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

391623:TERMP RS07755
gene id: 391623:TERMP_RS07755
uniprot id: F0LIT8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

391623:TERMP RS08355
gene id: 391623:TERMP_RS08355
uniprot id: F0LJM1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

391623:TERMP RS01200
gene id: 391623:TERMP_RS01200
uniprot id: F0LI63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

391623:TERMP RS05305
gene id: 391623:TERMP_RS05305
uniprot id: F0LMR1
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

391623:TERMP RS02295
gene id: 391623:TERMP_RS02295
uniprot id: F0LJH0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

391623:TERMP RS01510
gene id: 391623:TERMP_RS01510
uniprot id: F0LIK2
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

391623:TERMP RS03820
gene id: 391623:TERMP_RS03820
uniprot id: F0LL89
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

391623:TERMP RS04535
gene id: 391623:TERMP_RS04535
uniprot id: F0LM39
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Membrane

391623:TERMP RS01105
gene id: 391623:TERMP_RS01105
uniprot id: F0LI49
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

391623:TERMP RS06665
gene id: 391623:TERMP_RS06665
uniprot id: F0LHJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

391623:TERMP RS07740
gene id: 391623:TERMP_RS07740
uniprot id: F0LIT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

391623:TERMP RS04290
gene id: 391623:TERMP_RS04290
uniprot id: F0LLR1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

391623:TERMP RS06575
gene id: 391623:TERMP_RS06575
uniprot id: F0LHH1
names: Similarity
messages: Belongs to the AOR/FOR family.

391623:TERMP RS06755
gene id: 391623:TERMP_RS06755
uniprot id: F0LHT5
names: Similarity
messages: Belongs to the GbsR family.

391623:TERMP RS10815
gene id: 391623:TERMP_RS10815
uniprot id: F0LMD6
names: Similarity
messages: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family.

391623:TERMP RS06735
gene id: 391623:TERMP_RS06735
uniprot id: F0LHT1
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

391623:TERMP RS08870
gene id: 391623:TERMP_RS08870
uniprot id: F0LK57
names: Similarity
messages: Belongs to the carbamate kinase family.

391623:TERMP RS00880
gene id: 391623:TERMP_RS00880
uniprot id: F0LHS2
names: Function
names: Similarity
messages: Belongs to the HARP family.
messages: RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.

391623:TERMP RS10320
gene id: 391623:TERMP_RS10320
uniprot id: F0LLV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

391623:TERMP RS03530
gene id: 391623:TERMP_RS03530
uniprot id: F0LKV5
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

391623:TERMP RS01815
gene id: 391623:TERMP_RS01815
uniprot id: F0LIZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Dps family.
messages: Homododecamer. The 12 identical subunits form a hollow sphere into which the mineral iron core of up to 300 Fe(3+) can be deposited.
messages: Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction.
messages: nucleoid

391623:TERMP RS04750
gene id: 391623:TERMP_RS04750
uniprot id: F0LM80
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

391623:TERMP RS02260
gene id: 391623:TERMP_RS02260
uniprot id: F0LJG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclic 2,3-diphosphoglycerate synthetase family.
messages: Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP.
messages: Cytoplasm

391623:TERMP RS08175
gene id: 391623:TERMP_RS08175
uniprot id: F0LJA5
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

391623:TERMP RS07470
gene id: 391623:TERMP_RS07470
uniprot id: F0LIF4
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS07985
gene id: 391623:TERMP_RS07985
uniprot id: F0LJ64
names: Subunit
messages: Homotetramer.

391623:TERMP RS05295
gene id: 391623:TERMP_RS05295
uniprot id: F0LMQ8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

391623:TERMP RS07395
gene id: 391623:TERMP_RS07395
uniprot id: F0LID8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

391623:TERMP RS07325
gene id: 391623:TERMP_RS07325
uniprot id: F0LIC4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

391623:TERMP RS00635
gene id: 391623:TERMP_RS00635
uniprot id: F0LHM4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the RNA polymerase complex.

391623:TERMP RS05780
gene id: 391623:TERMP_RS05780
uniprot id: F0LN06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

391623:TERMP RS08670
gene id: 391623:TERMP_RS08670
uniprot id: F0LK16
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 2 family.
messages: Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

391623:TERMP RS10205
gene id: 391623:TERMP_RS10205
uniprot id: F0LLK3
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

391623:TERMP RS09745
gene id: 391623:TERMP_RS09745
uniprot id: F0LL37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

391623:TERMP RS00820
gene id: 391623:TERMP_RS00820
uniprot id: F0LHR0
names: Function
messages: Probably involved in the biogenesis of the ribosome.

391623:TERMP RS00620
gene id: 391623:TERMP_RS00620
uniprot id: F0LHM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

391623:TERMP RS06145
gene id: 391623:TERMP_RS06145
uniprot id: F0LH01
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS08435
gene id: 391623:TERMP_RS08435
uniprot id: F0LJN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

391623:TERMP RS00475
gene id: 391623:TERMP_RS00475
uniprot id: F0LHB4
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

391623:TERMP RS02025
gene id: 391623:TERMP_RS02025
uniprot id: F0LJ35
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
messages: Cytoplasm
messages: Homotetramer.

391623:TERMP RS00625
gene id: 391623:TERMP_RS00625
uniprot id: F0LHM2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

391623:TERMP RS00500
gene id: 391623:TERMP_RS00500
uniprot id: F0LHB9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

391623:TERMP RS00495
gene id: 391623:TERMP_RS00495
uniprot id: F0LHB8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

391623:TERMP RS00515
gene id: 391623:TERMP_RS00515
uniprot id: F0LHC2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

391623:TERMP RS03615
gene id: 391623:TERMP_RS03615
uniprot id: F0LKX2
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

391623:TERMP RS04780
gene id: 391623:TERMP_RS04780
uniprot id: F0LM86
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

391623:TERMP RS01575
gene id: 391623:TERMP_RS01575
uniprot id: F0LIL5
names: Similarity
messages: Belongs to the HypE family.

391623:TERMP RS03435
gene id: 391623:TERMP_RS03435
uniprot id: F0LKT7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

391623:TERMP RS00560
gene id: 391623:TERMP_RS00560
uniprot id: F0LHK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

391623:TERMP RS01280
gene id: 391623:TERMP_RS01280
uniprot id: F0LI75
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Homohexamer. Dimer of a homotrimer.
messages: Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage.

391623:TERMP RS04785
gene id: 391623:TERMP_RS04785
uniprot id: F0LM87
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

391623:TERMP RS00540
gene id: 391623:TERMP_RS00540
uniprot id: F0LHK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

391623:TERMP RS08455
gene id: 391623:TERMP_RS08455
uniprot id: F0LJP1
names: Similarity
messages: Belongs to the UPF0273 family.

391623:TERMP RS00715
gene id: 391623:TERMP_RS00715
uniprot id: F0LHN8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

391623:TERMP RS05595
gene id: 391623:TERMP_RS05595
uniprot id: F0LMW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

391623:TERMP RS00465
gene id: 391623:TERMP_RS00465
uniprot id: F0LHB2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

391623:TERMP RS00685
gene id: 391623:TERMP_RS00685
uniprot id: F0LHN2
names: Similarity
messages: Belongs to the MEMO1 family.

391623:TERMP RS09585
gene id: 391623:TERMP_RS09585
uniprot id: F0LL06
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-aspartate to produce beta-alanine.

391623:TERMP RS10620
gene id: 391623:TERMP_RS10620
uniprot id: F0LM96
names: Similarity
messages: Belongs to the AOR/FOR family.

391623:TERMP RS07105
gene id: 391623:TERMP_RS07105
uniprot id: F0LI09
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

391623:TERMP RS02960
gene id: 391623:TERMP_RS02960
uniprot id: F0LKB4
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS04465
gene id: 391623:TERMP_RS04465
uniprot id: F0LM25
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

391623:TERMP RS04890
gene id: 391623:TERMP_RS04890
uniprot id: F0LMH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

391623:TERMP RS02980
gene id: 391623:TERMP_RS02980
uniprot id: F0LKB8
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

391623:TERMP RS04075
gene id: 391623:TERMP_RS04075
uniprot id: F0LLL7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

391623:TERMP RS09260
gene id: 391623:TERMP_RS09260
uniprot id: F0LKL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

391623:TERMP RS03930
gene id: 391623:TERMP_RS03930
uniprot id: F0LLB4
names: Similarity
messages: Belongs to the AOR/FOR family.

391623:TERMP RS05860
gene id: 391623:TERMP_RS05860
uniprot id: F0LN24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

391623:TERMP RS05120
gene id: 391623:TERMP_RS05120
uniprot id: F0LMM3
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

391623:TERMP RS10680
gene id: 391623:TERMP_RS10680
uniprot id: F0LMA9
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

391623:TERMP RS01365
gene id: 391623:TERMP_RS01365
uniprot id: F0LIH4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

391623:TERMP RS04550
gene id: 391623:TERMP_RS04550
uniprot id: F0LM42
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

391623:TERMP RS09075
gene id: 391623:TERMP_RS09075
uniprot id: F0LKH6
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

391623:TERMP RS02400
gene id: 391623:TERMP_RS02400
uniprot id: F0LJJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

391623:TERMP RS05865
gene id: 391623:TERMP_RS05865
uniprot id: F0LN25
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

391623:TERMP RS00235
gene id: 391623:TERMP_RS00235
uniprot id: F0LH64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

391623:TERMP RS03350
gene id: 391623:TERMP_RS03350
uniprot id: F0LKS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

391623:TERMP RS09065
gene id: 391623:TERMP_RS09065
uniprot id: F0LKH4
names: Similarity
messages: Belongs to the AOR/FOR family.

391623:TERMP RS03800
gene id: 391623:TERMP_RS03800
uniprot id: F0LL85
names: Similarity
messages: Belongs to the arginase family.

391623:TERMP RS05335
gene id: 391623:TERMP_RS05335
uniprot id: F0LMR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

391623:TERMP RS05440
gene id: 391623:TERMP_RS05440
uniprot id: F0LMT9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

391623:TERMP RS02215
gene id: 391623:TERMP_RS02215
uniprot id: F0LJF4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

391623:TERMP RS00530
gene id: 391623:TERMP_RS00530
uniprot id: F0LHC5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

391623:TERMP RS01880
gene id: 391623:TERMP_RS01880
uniprot id: F0LJ04
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

391623:TERMP RS10155
gene id: 391623:TERMP_RS10155
uniprot id: F0LLJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Forms a Heterooligomeric complex of two stacked eight-membered rings.
messages: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

391623:TERMP RS04915
gene id: 391623:TERMP_RS04915
uniprot id: F0LMI2
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS02120
gene id: 391623:TERMP_RS02120
uniprot id: F0LJD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

391623:TERMP RS00360
gene id: 391623:TERMP_RS00360
uniprot id: F0LH90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

391623:TERMP RS09690
gene id: 391623:TERMP_RS09690
uniprot id: F0LL26
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

391623:TERMP RS05710
gene id: 391623:TERMP_RS05710
uniprot id: F0LMZ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

391623:TERMP RS01895
gene id: 391623:TERMP_RS01895
uniprot id: F0LJ08
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

391623:TERMP RS02045
gene id: 391623:TERMP_RS02045
uniprot id: F0LJ40
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

391623:TERMP RS02395
gene id: 391623:TERMP_RS02395
uniprot id: F0LJJ2
names: Similarity
messages: Belongs to the HypE family.

391623:TERMP RS00945
gene id: 391623:TERMP_RS00945
uniprot id: F0LI17
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

391623:TERMP RS03250
gene id: 391623:TERMP_RS03250
uniprot id: F0LKH1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

391623:TERMP RS09670
gene id: 391623:TERMP_RS09670
uniprot id: F0LL22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

391623:TERMP RS02990
gene id: 391623:TERMP_RS02990
uniprot id: F0LKC0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

391623:TERMP RS07895
gene id: 391623:TERMP_RS07895
uniprot id: F0LIW6
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

391623:TERMP RS10790
gene id: 391623:TERMP_RS10790
uniprot id: F0LMD1
names: Similarity
messages: Belongs to the band 7/mec-2 family.

391623:TERMP RS03640
gene id: 391623:TERMP_RS03640
uniprot id: F0LKX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

391623:TERMP RS00425
gene id: 391623:TERMP_RS00425
uniprot id: F0LHA3
names: Similarity
messages: Belongs to the ZPR1 family.

391623:TERMP RS06000
gene id: 391623:TERMP_RS06000
uniprot id: F0LGX1
names: Similarity
messages: Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.

391623:TERMP RS08190
gene id: 391623:TERMP_RS08190
uniprot id: F0LJA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

391623:TERMP RS03955
gene id: 391623:TERMP_RS03955
uniprot id: F0LLB9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

391623:TERMP RS06615
gene id: 391623:TERMP_RS06615
uniprot id: F0LHI0
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

391623:TERMP RS08445
gene id: 391623:TERMP_RS08445
uniprot id: F0LJN9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

391623:TERMP RS07550
gene id: 391623:TERMP_RS07550
uniprot id: F0LIP8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

391623:TERMP RS07320
gene id: 391623:TERMP_RS07320
uniprot id: F0LIC3
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS10130
gene id: 391623:TERMP_RS10130
uniprot id: F0LLI9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

391623:TERMP RS10235
gene id: 391623:TERMP_RS10235
uniprot id: F0LLU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

391623:TERMP RS01975
gene id: 391623:TERMP_RS01975
uniprot id: F0LJ25
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

391623:TERMP RS08900
gene id: 391623:TERMP_RS08900
uniprot id: F0LK63
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer. Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.

391623:TERMP RS03650
gene id: 391623:TERMP_RS03650
uniprot id: F0LL57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

391623:TERMP RS08310
gene id: 391623:TERMP_RS08310
uniprot id: F0LJL2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

391623:TERMP RS02195
gene id: 391623:TERMP_RS02195
uniprot id: F0LJE9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

391623:TERMP RS02550
gene id: 391623:TERMP_RS02550
uniprot id: F0LJV3
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS10880
gene id: 391623:TERMP_RS10880
uniprot id: F0LMF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

391623:TERMP RS05205
gene id: 391623:TERMP_RS05205
uniprot id: F0LMP0
names: Similarity
messages: Belongs to the UPF0179 family.

391623:TERMP RS07855
gene id: 391623:TERMP_RS07855
uniprot id: F0LIV9
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

391623:TERMP RS10085
gene id: 391623:TERMP_RS10085
uniprot id: F0LLI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

391623:TERMP RS07305
gene id: 391623:TERMP_RS07305
uniprot id: F0LIC0
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

391623:TERMP RS00370
gene id: 391623:TERMP_RS00370
uniprot id: F0LH92
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

391623:TERMP RS02265
gene id: 391623:TERMP_RS02265
uniprot id: F0LJG4
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS00445
gene id: 391623:TERMP_RS00445
uniprot id: F0LHA8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

391623:TERMP RS01570
gene id: 391623:TERMP_RS01570
uniprot id: F0LIL4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

391623:TERMP RS06610
gene id: 391623:TERMP_RS06610
uniprot id: F0LHH9
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

391623:TERMP RS01420
gene id: 391623:TERMP_RS01420
uniprot id: F0LII4
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS06725
gene id: 391623:TERMP_RS06725
uniprot id: F0LHK2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

391623:TERMP RS10290
gene id: 391623:TERMP_RS10290
uniprot id: F0LLV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

391623:TERMP RS02745
gene id: 391623:TERMP_RS02745
uniprot id: F0LJZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

391623:TERMP RS09455
gene id: 391623:TERMP_RS09455
uniprot id: F0LKQ1
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

391623:TERMP RS08970
gene id: 391623:TERMP_RS08970
uniprot id: F0LK77
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

391623:TERMP RS01205
gene id: 391623:TERMP_RS01205
uniprot id: F0LI64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

391623:TERMP RS08205
gene id: 391623:TERMP_RS08205
uniprot id: F0LJB1
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS07990
gene id: 391623:TERMP_RS07990
uniprot id: F0LJ65
names: Similarity
messages: Belongs to the UPF0147 family.

391623:TERMP RS06605
gene id: 391623:TERMP_RS06605
uniprot id: F0LHH8
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

391623:TERMP RS06705
gene id: 391623:TERMP_RS06705
uniprot id: F0LHJ8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

391623:TERMP RS07245
gene id: 391623:TERMP_RS07245
uniprot id: F0LIA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

391623:TERMP RS07780
gene id: 391623:TERMP_RS07780
uniprot id: F0LIU4
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

391623:TERMP RS04270
gene id: 391623:TERMP_RS04270
uniprot id: F0LLQ7
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS04575
gene id: 391623:TERMP_RS04575
uniprot id: F0LM47
names: Similarity
messages: Belongs to the HerA family.

391623:TERMP RS01790
gene id: 391623:TERMP_RS01790
uniprot id: F0LIY6
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

391623:TERMP RS07760
gene id: 391623:TERMP_RS07760
uniprot id: F0LIT9
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

391623:TERMP RS04255
gene id: 391623:TERMP_RS04255
uniprot id: F0LLQ4
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

391623:TERMP RS00725
gene id: 391623:TERMP_RS00725
uniprot id: F0LHP0
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

391623:TERMP RS07880
gene id: 391623:TERMP_RS07880
uniprot id: F0LIW3
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

391623:TERMP RS01635
gene id: 391623:TERMP_RS01635
uniprot id: F0LIM6
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS00320
gene id: 391623:TERMP_RS00320
uniprot id: F0LH82
names: Cofactor
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

391623:TERMP RS07420
gene id: 391623:TERMP_RS07420
uniprot id: F0LIE3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

391623:TERMP RS08300
gene id: 391623:TERMP_RS08300
uniprot id: F0LJL0
names: Similarity
messages: Belongs to the UPF0216 family.

391623:TERMP RS09680
gene id: 391623:TERMP_RS09680
uniprot id: F0LL24
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

391623:TERMP RS04980
gene id: 391623:TERMP_RS04980
uniprot id: F0LMJ5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

391623:TERMP RS01960
gene id: 391623:TERMP_RS01960
uniprot id: F0LJ22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

391623:TERMP RS06405
gene id: 391623:TERMP_RS06405
uniprot id: F0LHD7
names: Subcellular Location Annotation
messages: Cytoplasm

391623:TERMP RS06365
gene id: 391623:TERMP_RS06365
uniprot id: F0LHC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

391623:TERMP RS02355
gene id: 391623:TERMP_RS02355
uniprot id: F0LJI3
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

391623:TERMP RS09000
gene id: 391623:TERMP_RS09000
uniprot id: F0LK83
names: Subcellular Location Annotation
messages: Membrane

391623:TERMP RS09970
gene id: 391623:TERMP_RS09970
uniprot id: F0LLF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.