389348:PNK RS10055
gene id: 389348:PNK_RS10055
uniprot id: A0A0U5JES8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS09445
gene id: 389348:PNK_RS09445
uniprot id: A0A0U5JED2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

389348:PNK RS05040
gene id: 389348:PNK_RS05040
uniprot id: A0A0U5ER65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

389348:PNK RS04285
gene id: 389348:PNK_RS04285
uniprot id: A0A0U5JDL9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

389348:PNK RS04060
gene id: 389348:PNK_RS04060
uniprot id: A0A0U5JAI7
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

389348:PNK RS07860
gene id: 389348:PNK_RS07860
uniprot id: A0A0U5JBG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

389348:PNK RS12800
gene id: 389348:PNK_RS12800
uniprot id: A0A0U5JH92
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

389348:PNK RS03990
gene id: 389348:PNK_RS03990
uniprot id: S4TKN5
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

389348:PNK RS04770
gene id: 389348:PNK_RS04770
uniprot id: A0A0U5JDW7
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

389348:PNK RS12275
gene id: 389348:PNK_RS12275
uniprot id: A0A0U5JGX9
names: Similarity
messages: Belongs to the MobA/MobL family.

389348:PNK RS01095
gene id: 389348:PNK_RS01095
uniprot id: A0A0U5EPC3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

389348:PNK RS00670
gene id: 389348:PNK_RS00670
uniprot id: A0A0U5CMG6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.
messages: Homodimer.
messages: Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.

389348:PNK RS03445
gene id: 389348:PNK_RS03445
uniprot id: A0A0U5JEK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

389348:PNK RS06070
gene id: 389348:PNK_RS06070
uniprot id: A0A0U5JDF7
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

389348:PNK RS02715
gene id: 389348:PNK_RS02715
uniprot id: A0A0U5JBV7
names: Function
names: Similarity
messages: Belongs to the LpxB family.
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

389348:PNK RS01260
gene id: 389348:PNK_RS01260
uniprot id: A0A0U5EPJ5
names: Cofactor
names: Similarity
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.

389348:PNK RS03975
gene id: 389348:PNK_RS03975
uniprot id: A0A0U5JBF2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

389348:PNK RS06690
gene id: 389348:PNK_RS06690
uniprot id: A0A0U5ES00
names: Similarity
messages: Belongs to the LOG family.

389348:PNK RS00330
gene id: 389348:PNK_RS00330
uniprot id: A0A0U5J7I7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

389348:PNK RS09800
gene id: 389348:PNK_RS09800
uniprot id: A0A0U5CRG1
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS05975
gene id: 389348:PNK_RS05975
uniprot id: A0A0U5JGE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

389348:PNK RS06005
gene id: 389348:PNK_RS06005
uniprot id: A0A0U5CPW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

389348:PNK RS06785
gene id: 389348:PNK_RS06785
uniprot id: A0A0U5ES20
names: Similarity
messages: Belongs to the ribF family.

389348:PNK RS01250
gene id: 389348:PNK_RS01250
uniprot id: A0A0U5EPD6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

389348:PNK RS06805
gene id: 389348:PNK_RS06805
uniprot id: A0A0U5JCW3
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

389348:PNK RS12850
gene id: 389348:PNK_RS12850
uniprot id: A0A0U5EVA9
names: Similarity
messages: Belongs to the UPF0137 (pGP6-D) family.

389348:PNK RS05645
gene id: 389348:PNK_RS05645
uniprot id: A0A0U5JD97
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS09450
gene id: 389348:PNK_RS09450
uniprot id: A0A0U5JCA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

389348:PNK RS12600
gene id: 389348:PNK_RS12600
uniprot id: A0A0U5JDU2
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

389348:PNK RS05295
gene id: 389348:PNK_RS05295
uniprot id: A0A0U5CPN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

389348:PNK RS02415
gene id: 389348:PNK_RS02415
uniprot id: A0A0U5EQ52
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

389348:PNK RS02185
gene id: 389348:PNK_RS02185
uniprot id: A0A0U5JAC2
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

389348:PNK RS00060
gene id: 389348:PNK_RS00060
uniprot id: A0A0U5EPB0
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

389348:PNK RS03045
gene id: 389348:PNK_RS03045
uniprot id: A0A0U5EQ54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

389348:PNK RS03710
gene id: 389348:PNK_RS03710
uniprot id: A0A0U5JC40
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS10100
gene id: 389348:PNK_RS10100
uniprot id: A0A0U5JIL5
names: Similarity
messages: Belongs to the GcvT family.

389348:PNK RS01115
gene id: 389348:PNK_RS01115
uniprot id: A0A0U5JDC0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS01695
gene id: 389348:PNK_RS01695
uniprot id: A0A0U5J7B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Membrane

389348:PNK RS10150
gene id: 389348:PNK_RS10150
uniprot id: A0A0U5ETR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

389348:PNK RS10700
gene id: 389348:PNK_RS10700
uniprot id: A0A0U5K6H3
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

389348:PNK RS04270
gene id: 389348:PNK_RS04270
uniprot id: A0A0U5CP49
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

389348:PNK RS08650
gene id: 389348:PNK_RS08650
uniprot id: A0A0U5JDW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

389348:PNK RS01475
gene id: 389348:PNK_RS01475
uniprot id: A0A0U5JA43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

389348:PNK RS05545
gene id: 389348:PNK_RS05545
uniprot id: A0A0U5JEC7
names: Similarity
messages: Belongs to the class-C beta-lactamase family.

389348:PNK RS11245
gene id: 389348:PNK_RS11245
uniprot id: A0A0U5JIR3
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

389348:PNK RS03970
gene id: 389348:PNK_RS03970
uniprot id: A0A0U5CP04
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

389348:PNK RS02310
gene id: 389348:PNK_RS02310
uniprot id: A0A0U5J9I4
names: Similarity
messages: Belongs to the UDPGP type 1 family.

389348:PNK RS08585
gene id: 389348:PNK_RS08585
uniprot id: A0A0U5JEU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

389348:PNK RS03705
gene id: 389348:PNK_RS03705
uniprot id: A0A0U5J8I2
names: Similarity
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

389348:PNK RS09100
gene id: 389348:PNK_RS09100
uniprot id: A0A0U5JFT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Cytoplasm

389348:PNK RS07805
gene id: 389348:PNK_RS07805
uniprot id: A0A0U5JCG4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

389348:PNK RS02070
gene id: 389348:PNK_RS02070
uniprot id: A0A0U5JCF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

389348:PNK RS07815
gene id: 389348:PNK_RS07815
uniprot id: A0A0U5ESJ7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

389348:PNK RS00560
gene id: 389348:PNK_RS00560
uniprot id: A0A0U5JD92
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS11430
gene id: 389348:PNK_RS11430
uniprot id: A0A0U5K6V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

389348:PNK RS10745
gene id: 389348:PNK_RS10745
uniprot id: A0A0U5JGP0
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

389348:PNK RS03035
gene id: 389348:PNK_RS03035
uniprot id: A0A0U5EQC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatase IpgD/SopB family.
messages: Secreted

389348:PNK RS06940
gene id: 389348:PNK_RS06940
uniprot id: A0A0U5ES72
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

389348:PNK RS07360
gene id: 389348:PNK_RS07360
uniprot id: A0A0U5ES99
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

389348:PNK RS09650
gene id: 389348:PNK_RS09650
uniprot id: A0A0U5JDG0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

389348:PNK RS08510
gene id: 389348:PNK_RS08510
uniprot id: A0A0U5K5D7
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

389348:PNK RS05370
gene id: 389348:PNK_RS05370
uniprot id: A0A0U5K3K0
names: Subcellular Location Annotation
messages: Periplasm

389348:PNK RS07915
gene id: 389348:PNK_RS07915
uniprot id: A0A0U5ESJ2
names: Similarity
messages: Belongs to the asp23 family.

389348:PNK RS05520
gene id: 389348:PNK_RS05520
uniprot id: A0A0U5JD40
names: Similarity
messages: Belongs to the ComB family.

389348:PNK RS07450
gene id: 389348:PNK_RS07450
uniprot id: A0A0U5JH46
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.
messages: Homodimer.
messages: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.

389348:PNK RS09680
gene id: 389348:PNK_RS09680
uniprot id: A0A0U5JFH6
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

389348:PNK RS11980
gene id: 389348:PNK_RS11980
uniprot id: A0A0U5JGJ6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

389348:PNK RS00905
gene id: 389348:PNK_RS00905
uniprot id: A0A0U5K145
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

389348:PNK RS06100
gene id: 389348:PNK_RS06100
uniprot id: A0A0U5ERP3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

389348:PNK RS04295
gene id: 389348:PNK_RS04295
uniprot id: A0A0U5EQX8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

389348:PNK RS11190
gene id: 389348:PNK_RS11190
uniprot id: A0A0U5K6R2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

389348:PNK RS04235
gene id: 389348:PNK_RS04235
uniprot id: A0A0U5JF17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

389348:PNK RS07375
gene id: 389348:PNK_RS07375
uniprot id: A0A0U5JH35
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

389348:PNK RS13535
gene id: 389348:PNK_RS13535
uniprot id: A0A0U5JHJ3
names: Similarity
messages: Belongs to the UPF0111 family.

389348:PNK RS02010
gene id: 389348:PNK_RS02010
uniprot id: A0A0U5JB70
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

389348:PNK RS09335
gene id: 389348:PNK_RS09335
uniprot id: A0A0U5ETG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

389348:PNK RS11130
gene id: 389348:PNK_RS11130
uniprot id: A0A0U5EUH8
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

389348:PNK RS11150
gene id: 389348:PNK_RS11150
uniprot id: A0A0U5JIN6
names: Caution
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS03520
gene id: 389348:PNK_RS03520
uniprot id: A0A0U5JF11
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

389348:PNK RS10220
gene id: 389348:PNK_RS10220
uniprot id: A0A0U5JDS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III.

389348:PNK RS07525
gene id: 389348:PNK_RS07525
uniprot id: A0A0U5JH61
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase family.
messages: Binds 1 FAD per subunit.

389348:PNK RS02740
gene id: 389348:PNK_RS02740
uniprot id: A0A0U5JAP2
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

389348:PNK RS07365
gene id: 389348:PNK_RS07365
uniprot id: A0A0U5JE73
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

389348:PNK RS09630
gene id: 389348:PNK_RS09630
uniprot id: S4TKN7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

389348:PNK RS01050
gene id: 389348:PNK_RS01050
uniprot id: A0A0U5J7W2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

389348:PNK RS03115
gene id: 389348:PNK_RS03115
uniprot id: A0A0U5EQD8
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

389348:PNK RS04715
gene id: 389348:PNK_RS04715
uniprot id: A0A0U5JCR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

389348:PNK RS02250
gene id: 389348:PNK_RS02250
uniprot id: A0A0U5EPV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

389348:PNK RS02425
gene id: 389348:PNK_RS02425
uniprot id: A0A0U5JE09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

389348:PNK RS02290
gene id: 389348:PNK_RS02290
uniprot id: A0A0U5JBA2
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

389348:PNK RS00615
gene id: 389348:PNK_RS00615
uniprot id: A0A0U5EPI0
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

389348:PNK RS10720
gene id: 389348:PNK_RS10720
uniprot id: A0A0U5JH59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

389348:PNK RS04260
gene id: 389348:PNK_RS04260
uniprot id: A0A0U5JCC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

389348:PNK RS13850
gene id: 389348:PNK_RS13850
uniprot id: A0A0U5EPV8
names: Similarity
messages: Belongs to the bacterial secretin family.

389348:PNK RS02805
gene id: 389348:PNK_RS02805
uniprot id: A0A0U5EQ17
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

389348:PNK RS01040
gene id: 389348:PNK_RS01040
uniprot id: A0A0U5JDJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

389348:PNK RS03010
gene id: 389348:PNK_RS03010
uniprot id: A0A0U5JAY0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

389348:PNK RS07850
gene id: 389348:PNK_RS07850
uniprot id: A0A0U5JHC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

389348:PNK RS10875
gene id: 389348:PNK_RS10875
uniprot id: A0A0U5JF89
names: Similarity
messages: Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.

389348:PNK RS04825
gene id: 389348:PNK_RS04825
uniprot id: A0A0U5JCP1
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS00605
gene id: 389348:PNK_RS00605
uniprot id: A0A0U5JBL7
names: Similarity
messages: Belongs to the intimin/invasin family.

389348:PNK RS08145
gene id: 389348:PNK_RS08145
uniprot id: A0A0U5ESV3
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

389348:PNK RS01510
gene id: 389348:PNK_RS01510
uniprot id: A0A0U5JAY2
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

389348:PNK RS00765
gene id: 389348:PNK_RS00765
uniprot id: A0A0U5JBP4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

389348:PNK RS04470
gene id: 389348:PNK_RS04470
uniprot id: A0A0U5EQT2
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS06555
gene id: 389348:PNK_RS06555
uniprot id: A0A0U5K4C4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

389348:PNK RS11675
gene id: 389348:PNK_RS11675
uniprot id: A0A0U5JFQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpA family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

389348:PNK RS10250
gene id: 389348:PNK_RS10250
uniprot id: A0A0U5JI50
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

389348:PNK RS11585
gene id: 389348:PNK_RS11585
uniprot id: A0A0U5JD65
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

389348:PNK RS12200
gene id: 389348:PNK_RS12200
uniprot id: A0A0U5JJ90
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

389348:PNK RS01585
gene id: 389348:PNK_RS01585
uniprot id: A0A0U5JB97
names: Similarity
messages: Belongs to the heat shock protein 70 family.

389348:PNK RS05315
gene id: 389348:PNK_RS05315
uniprot id: A0A0U5ER94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M4 family.
messages: Extracellular zinc metalloprotease.
messages: Secreted

389348:PNK RS06105
gene id: 389348:PNK_RS06105
uniprot id: A0A0U5ERT0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

389348:PNK RS09520
gene id: 389348:PNK_RS09520
uniprot id: A0A0U5JIA9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS11250
gene id: 389348:PNK_RS11250
uniprot id: A0A0U5JJ85
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS01500
gene id: 389348:PNK_RS01500
uniprot id: A0A0U5JB82
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.

389348:PNK RS08500
gene id: 389348:PNK_RS08500
uniprot id: A0A0U5JBA3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

389348:PNK RS02460
gene id: 389348:PNK_RS02460
uniprot id: A0A0U5CNB0
names: Similarity
messages: Belongs to the HAM1 NTPase family.

389348:PNK RS05275
gene id: 389348:PNK_RS05275
uniprot id: A0A0U5JA47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

389348:PNK RS04500
gene id: 389348:PNK_RS04500
uniprot id: A0A0U5J910
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Catalyzes the sodium-dependent uptake of extracellular L-proline.
messages: Cell membrane
messages: Membrane

389348:PNK RS06590
gene id: 389348:PNK_RS06590
uniprot id: A0A0U5JED0
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

389348:PNK RS06870
gene id: 389348:PNK_RS06870
uniprot id: A0A0U5ES28
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

389348:PNK RS07905
gene id: 389348:PNK_RS07905
uniprot id: A0A0U5ESS9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

389348:PNK RS07430
gene id: 389348:PNK_RS07430
uniprot id: A0A0U5ESF5
names: Function
names: Similarity
messages: Belongs to the RecD family. RecD-like subfamily.
messages: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.

389348:PNK RS01955
gene id: 389348:PNK_RS01955
uniprot id: A0A0U5J7G5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

389348:PNK RS10360
gene id: 389348:PNK_RS10360
uniprot id: A0A0U5K6A9
names: Similarity
messages: Belongs to the RutC family.

389348:PNK RS09875
gene id: 389348:PNK_RS09875
uniprot id: A0A0U5K626
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

389348:PNK RS04290
gene id: 389348:PNK_RS04290
uniprot id: A0A0U5EQQ1
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

389348:PNK RS08250
gene id: 389348:PNK_RS08250
uniprot id: A0A0U5JHJ2
names: Similarity
messages: Belongs to the V-ATPase D subunit family.

389348:PNK RS02040
gene id: 389348:PNK_RS02040
uniprot id: A0A0U5J7I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

389348:PNK RS02125
gene id: 389348:PNK_RS02125
uniprot id: A0A0U5JB66
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS02120
gene id: 389348:PNK_RS02120
uniprot id: A0A0U5J7K3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

389348:PNK RS09675
gene id: 389348:PNK_RS09675
uniprot id: A0A0U5ETG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

389348:PNK RS11470
gene id: 389348:PNK_RS11470
uniprot id: A0A0U5JH25
names: Similarity
messages: Belongs to the sigma-54 factor family.

389348:PNK RS01920
gene id: 389348:PNK_RS01920
uniprot id: A0A0U5JB55
names: Subcellular Location Annotation
messages: Cytoplasm

389348:PNK RS04840
gene id: 389348:PNK_RS04840
uniprot id: A0A0U5JBX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

389348:PNK RS07565
gene id: 389348:PNK_RS07565
uniprot id: A0A0U5JCC2
names: Similarity
messages: Belongs to the LcrH/SycD chaperone family.

389348:PNK RS06845
gene id: 389348:PNK_RS06845
uniprot id: A0A0U5JF31
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

389348:PNK RS09525
gene id: 389348:PNK_RS09525
uniprot id: A0A0U5JEE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

389348:PNK RS08690
gene id: 389348:PNK_RS08690
uniprot id: A0A0U5JG48
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

389348:PNK RS01080
gene id: 389348:PNK_RS01080
uniprot id: A0A0U5J8U9
names: Similarity
messages: Belongs to the peptidase S41A family.

389348:PNK RS01750
gene id: 389348:PNK_RS01750
uniprot id: A0A0U5JB27
names: Similarity
messages: Belongs to the LcrH/SycD chaperone family.

389348:PNK RS11475
gene id: 389348:PNK_RS11475
uniprot id: A0A0U5EUF2
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

389348:PNK RS09085
gene id: 389348:PNK_RS09085
uniprot id: A0A0U5JGB3
names: Similarity
messages: Belongs to the FPG family.

389348:PNK RS09655
gene id: 389348:PNK_RS09655
uniprot id: A0A0U5JGK7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

389348:PNK RS02265
gene id: 389348:PNK_RS02265
uniprot id: A0A0U5JE97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

389348:PNK RS11280
gene id: 389348:PNK_RS11280
uniprot id: A0A0U5CS72
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

389348:PNK RS11990
gene id: 389348:PNK_RS11990
uniprot id: A0A0U5CSK1
names: Similarity
messages: Belongs to the UPF0137 (pGP6-D) family.

389348:PNK RS07845
gene id: 389348:PNK_RS07845
uniprot id: A0A0U5JGX6
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

389348:PNK RS04570
gene id: 389348:PNK_RS04570
uniprot id: A0A0U5JFM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

389348:PNK RS06810
gene id: 389348:PNK_RS06810
uniprot id: A0A0U5JAY3
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS10035
gene id: 389348:PNK_RS10035
uniprot id: A0A0U5JC76
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS06880
gene id: 389348:PNK_RS06880
uniprot id: A0A0U5JGF4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

389348:PNK RS02555
gene id: 389348:PNK_RS02555
uniprot id: A0A0U5JCN2
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

389348:PNK RS06930
gene id: 389348:PNK_RS06930
uniprot id: A0A0U5JF47
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

389348:PNK RS03190
gene id: 389348:PNK_RS03190
uniprot id: A0A0U5EQF0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

389348:PNK RS09720
gene id: 389348:PNK_RS09720
uniprot id: A0A0U5CRE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

389348:PNK RS02200
gene id: 389348:PNK_RS02200
uniprot id: A0A0U5JB85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

389348:PNK RS00290
gene id: 389348:PNK_RS00290
uniprot id: A0A0U5EP23
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS11445
gene id: 389348:PNK_RS11445
uniprot id: A0A0U5JEG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

389348:PNK RS02560
gene id: 389348:PNK_RS02560
uniprot id: A0A0U5EPW6
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS07445
gene id: 389348:PNK_RS07445
uniprot id: A0A0U5JGQ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

389348:PNK RS11665
gene id: 389348:PNK_RS11665
uniprot id: A0A0U5K6Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpC family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

389348:PNK RS12070
gene id: 389348:PNK_RS12070
uniprot id: A0A0U5K777
names: Similarity
messages: Belongs to the heat shock protein 70 family.

389348:PNK RS07485
gene id: 389348:PNK_RS07485
uniprot id: A0A0U5JCB6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family. RnhC subfamily.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

389348:PNK RS00360
gene id: 389348:PNK_RS00360
uniprot id: A0A0U5J8G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

389348:PNK RS08200
gene id: 389348:PNK_RS08200
uniprot id: A0A0U5CQV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

389348:PNK RS04810
gene id: 389348:PNK_RS04810
uniprot id: A0A0U5JBU7
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

389348:PNK RS05750
gene id: 389348:PNK_RS05750
uniprot id: A0A0U5J9R9
names: Similarity
messages: Belongs to the SUI1 family.

389348:PNK RS08195
gene id: 389348:PNK_RS08195
uniprot id: A0A0U5K578
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

389348:PNK RS02985
gene id: 389348:PNK_RS02985
uniprot id: A0A0U5J8X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

389348:PNK RS00960
gene id: 389348:PNK_RS00960
uniprot id: A0A0U5JDH9
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

389348:PNK RS08480
gene id: 389348:PNK_RS08480
uniprot id: A0A0U5JET5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

389348:PNK RS01330
gene id: 389348:PNK_RS01330
uniprot id: A0A0U5EPS0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

389348:PNK RS09625
gene id: 389348:PNK_RS09625
uniprot id: A0A0U5JBY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

389348:PNK RS08920
gene id: 389348:PNK_RS08920
uniprot id: A0A0U5JD23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADP/ATP translocase tlc family.
messages: Membrane

389348:PNK RS05710
gene id: 389348:PNK_RS05710
uniprot id: A0A0U5ERK1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS05515
gene id: 389348:PNK_RS05515
uniprot id: A0A0U5J9M3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

389348:PNK RS07605
gene id: 389348:PNK_RS07605
uniprot id: A0A0U5JH79
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS03915
gene id: 389348:PNK_RS03915
uniprot id: A0A0U5EQR9
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

389348:PNK RS00780
gene id: 389348:PNK_RS00780
uniprot id: A0A0U5JAU5
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

389348:PNK RS03370
gene id: 389348:PNK_RS03370
uniprot id: A0A0U5JEX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

389348:PNK RS04000
gene id: 389348:PNK_RS04000
uniprot id: A0A0U5JCQ2
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

389348:PNK RS03170
gene id: 389348:PNK_RS03170
uniprot id: A0A0U5JB09
names: Similarity
messages: Belongs to the Nudix hydrolase family.

389348:PNK RS09500
gene id: 389348:PNK_RS09500
uniprot id: A0A0U5JFZ4
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

389348:PNK RS05935
gene id: 389348:PNK_RS05935
uniprot id: A0A0U5JBM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Membrane

389348:PNK RS00990
gene id: 389348:PNK_RS00990
uniprot id: A0A0U5CML4
names: Similarity
messages: Belongs to the peptidase S13 family.

389348:PNK RS08215
gene id: 389348:PNK_RS08215
uniprot id: A0A0U5JFT2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

389348:PNK RS07385
gene id: 389348:PNK_RS07385
uniprot id: A0A0U5JB80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

389348:PNK RS08525
gene id: 389348:PNK_RS08525
uniprot id: S4TL49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

389348:PNK RS06925
gene id: 389348:PNK_RS06925
uniprot id: A0A0U5JC37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

389348:PNK RS10380
gene id: 389348:PNK_RS10380
uniprot id: A0A0U5JH02
names: Similarity
messages: Belongs to the glycosyl hydrolase 63 family.

389348:PNK RS10930
gene id: 389348:PNK_RS10930
uniprot id: A0A0U5JD53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

389348:PNK RS03950
gene id: 389348:PNK_RS03950
uniprot id: A0A0U5J9F1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

389348:PNK RS05715
gene id: 389348:PNK_RS05715
uniprot id: A0A0U5JDU0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS01815
gene id: 389348:PNK_RS01815
uniprot id: A0A0U5JC97
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

389348:PNK RS00660
gene id: 389348:PNK_RS00660
uniprot id: A0A0U5JA85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

389348:PNK RS11385
gene id: 389348:PNK_RS11385
uniprot id: A0A0U5JH09
names: Similarity
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

389348:PNK RS01915
gene id: 389348:PNK_RS01915
uniprot id: A0A0U5EPR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

389348:PNK RS07825
gene id: 389348:PNK_RS07825
uniprot id: A0A0U5JF13
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

389348:PNK RS09330
gene id: 389348:PNK_RS09330
uniprot id: A0A0U5ETG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

389348:PNK RS02950
gene id: 389348:PNK_RS02950
uniprot id: A0A0U5EQB4
names: Similarity
messages: Belongs to the phosphohexose mutase family.

389348:PNK RS09375
gene id: 389348:PNK_RS09375
uniprot id: A0A0U5JC98
names: Similarity
messages: Belongs to the FtsK/SpoIIIE/SftA family.

389348:PNK RS04510
gene id: 389348:PNK_RS04510
uniprot id: A0A0U5K365
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Catalyzes the sodium-dependent uptake of extracellular L-proline.
messages: Cell membrane
messages: Membrane

389348:PNK RS06130
gene id: 389348:PNK_RS06130
uniprot id: A0A0U5JGH1
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

389348:PNK RS09715
gene id: 389348:PNK_RS09715
uniprot id: A0A0U5K5Z5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

389348:PNK RS06950
gene id: 389348:PNK_RS06950
uniprot id: A0A0U5ES38
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

389348:PNK RS01245
gene id: 389348:PNK_RS01245
uniprot id: A0A0U5JBY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

389348:PNK RS06455
gene id: 389348:PNK_RS06455
uniprot id: A0A0U5JAS2
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS10980
gene id: 389348:PNK_RS10980
uniprot id: A0A0U5EU56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

389348:PNK RS00180
gene id: 389348:PNK_RS00180
uniprot id: A0A0U5J9Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

389348:PNK RS04390
gene id: 389348:PNK_RS04390
uniprot id: A0A0U5EQS3
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS06970
gene id: 389348:PNK_RS06970
uniprot id: A0A0U5JCZ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

389348:PNK RS02810
gene id: 389348:PNK_RS02810
uniprot id: A0A0U5JBM7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

389348:PNK RS03420
gene id: 389348:PNK_RS03420
uniprot id: A0A0U5EQA1
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

389348:PNK RS01265
gene id: 389348:PNK_RS01265
uniprot id: A0A0U5JAS9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

389348:PNK RS00080
gene id: 389348:PNK_RS00080
uniprot id: A0A0U5JCS7
names: Similarity
messages: Belongs to the peptidase C59 family.

389348:PNK RS06065
gene id: 389348:PNK_RS06065
uniprot id: A0A0U5J9Z4
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

389348:PNK RS11965
gene id: 389348:PNK_RS11965
uniprot id: A0A0U5JFP6
names: Similarity
messages: Belongs to the XFP family.

389348:PNK RS04735
gene id: 389348:PNK_RS04735
uniprot id: A0A0U5J9V9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

389348:PNK RS09685
gene id: 389348:PNK_RS09685
uniprot id: A0A0U5JHU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

389348:PNK RS12180
gene id: 389348:PNK_RS12180
uniprot id: A0A0U5EV51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

389348:PNK RS06780
gene id: 389348:PNK_RS06780
uniprot id: A0A0U5JEG3
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

389348:PNK RS10950
gene id: 389348:PNK_RS10950
uniprot id: A0A0U5JFA5
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

389348:PNK RS06710
gene id: 389348:PNK_RS06710
uniprot id: A0A0U5JDW0
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

389348:PNK RS09690
gene id: 389348:PNK_RS09690
uniprot id: A0A0U5JIE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

389348:PNK RS05475
gene id: 389348:PNK_RS05475
uniprot id: A0A0U5ERF9
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

389348:PNK RS08555
gene id: 389348:PNK_RS08555
uniprot id: A0A0U5JFE8
names: Similarity
messages: Belongs to the heat shock protein 70 family.

389348:PNK RS01280
gene id: 389348:PNK_RS01280
uniprot id: A0A0U5J9X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADP/ATP translocase tlc family.
messages: Membrane

389348:PNK RS08845
gene id: 389348:PNK_RS08845
uniprot id: A0A0U5JG66
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS03380
gene id: 389348:PNK_RS03380
uniprot id: A0A0U5J943
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

389348:PNK RS04210
gene id: 389348:PNK_RS04210
uniprot id: A0A0U5EQN5
names: Similarity
messages: Belongs to the citrate synthase family.

389348:PNK RS04035
gene id: 389348:PNK_RS04035
uniprot id: A0A0U5J8P6
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS00355
gene id: 389348:PNK_RS00355
uniprot id: A0A0U5J9G0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.

389348:PNK RS06765
gene id: 389348:PNK_RS06765
uniprot id: A0A0U5JF16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

389348:PNK RS04300
gene id: 389348:PNK_RS04300
uniprot id: A0A0U5JCX1
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

389348:PNK RS04315
gene id: 389348:PNK_RS04315
uniprot id: A0A0U5JF35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MlaE permease family.
messages: Membrane

389348:PNK RS06705
gene id: 389348:PNK_RS06705
uniprot id: A0A0U5ERZ4
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

389348:PNK RS10430
gene id: 389348:PNK_RS10430
uniprot id: A0A0U5JCH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

389348:PNK RS09465
gene id: 389348:PNK_RS09465
uniprot id: A0A0U5K5V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

389348:PNK RS08855
gene id: 389348:PNK_RS08855
uniprot id: A0A0U5ET98
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

389348:PNK RS02650
gene id: 389348:PNK_RS02650
uniprot id: A0A0U5JBU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

389348:PNK RS00490
gene id: 389348:PNK_RS00490
uniprot id: A0A0U5J6Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell membrane
messages: Membrane

389348:PNK RS05485
gene id: 389348:PNK_RS05485
uniprot id: A0A0U5ERB3
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.

389348:PNK RS06045
gene id: 389348:PNK_RS06045
uniprot id: A0A0U5JDI4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

389348:PNK RS07440
gene id: 389348:PNK_RS07440
uniprot id: A0A0U5JE89
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

389348:PNK RS08255
gene id: 389348:PNK_RS08255
uniprot id: A0A0U5JDN6
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.

389348:PNK RS04140
gene id: 389348:PNK_RS04140
uniprot id: A0A0U5EQW0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS00855
gene id: 389348:PNK_RS00855
uniprot id: A0A0U5EPK5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

389348:PNK RS03265
gene id: 389348:PNK_RS03265
uniprot id: A0A0U5EQ78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

389348:PNK RS06935
gene id: 389348:PNK_RS06935
uniprot id: A0A0U5ES53
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

389348:PNK RS03260
gene id: 389348:PNK_RS03260
uniprot id: A0A0U5JD21
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

389348:PNK RS08775
gene id: 389348:PNK_RS08775
uniprot id: A0A0U5ET90
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

389348:PNK RS01235
gene id: 389348:PNK_RS01235
uniprot id: A0A0U5J9Z0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

389348:PNK RS11175
gene id: 389348:PNK_RS11175
uniprot id: A0A0U5JDA1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS03040
gene id: 389348:PNK_RS03040
uniprot id: A0A0U5JC38
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS10650
gene id: 389348:PNK_RS10650
uniprot id: A0A0U5EU55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

389348:PNK RS07045
gene id: 389348:PNK_RS07045
uniprot id: A0A0U5JGX5
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

389348:PNK RS03920
gene id: 389348:PNK_RS03920
uniprot id: A0A0U5JCN4
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

389348:PNK RS10895
gene id: 389348:PNK_RS10895
uniprot id: A0A0U5EUB7
names: Similarity
messages: Belongs to the glycosyl hydrolase 81 family.

389348:PNK RS10760
gene id: 389348:PNK_RS10760
uniprot id: A0A0U5JIE8
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

389348:PNK RS04940
gene id: 389348:PNK_RS04940
uniprot id: A0A0U5ER24
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

389348:PNK RS04415
gene id: 389348:PNK_RS04415
uniprot id: A0A0U5J9P5
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS00620
gene id: 389348:PNK_RS00620
uniprot id: A0A0U5JAR0
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

389348:PNK RS09405
gene id: 389348:PNK_RS09405
uniprot id: A0A0U5JGH2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

389348:PNK RS10320
gene id: 389348:PNK_RS10320
uniprot id: A0A0U5ETU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

389348:PNK RS01195
gene id: 389348:PNK_RS01195
uniprot id: A0A0U5JDD6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

389348:PNK RS01735
gene id: 389348:PNK_RS01735
uniprot id: A0A0U5EPX5
names: Similarity
messages: Belongs to the LcrH/SycD chaperone family.

389348:PNK RS10400
gene id: 389348:PNK_RS10400
uniprot id: A0A0U5ETV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

389348:PNK RS10025
gene id: 389348:PNK_RS10025
uniprot id: A0A0U5JEN5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

389348:PNK RS05220
gene id: 389348:PNK_RS05220
uniprot id: A0A0U5JC30
names: Similarity
messages: Belongs to the truncated hemoglobin family. Group II subfamily.

389348:PNK RS02105
gene id: 389348:PNK_RS02105
uniprot id: A0A0U5JE56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

389348:PNK RS02830
gene id: 389348:PNK_RS02830
uniprot id: A0A0U5J7Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Periplasm

389348:PNK RS10710
gene id: 389348:PNK_RS10710
uniprot id: A0A0U5JF63
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

389348:PNK RS03395
gene id: 389348:PNK_RS03395
uniprot id: A0A0U5K2I4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

389348:PNK RS09925
gene id: 389348:PNK_RS09925
uniprot id: A0A0U5ETK8
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

389348:PNK RS11230
gene id: 389348:PNK_RS11230
uniprot id: A0A0U5JGX4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

389348:PNK RS04525
gene id: 389348:PNK_RS04525
uniprot id: A0A0U5JBQ9
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

389348:PNK RS04800
gene id: 389348:PNK_RS04800
uniprot id: A0A0U5JFD0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

389348:PNK RS07190
gene id: 389348:PNK_RS07190
uniprot id: A0A0U5ESA4
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

389348:PNK RS03215
gene id: 389348:PNK_RS03215
uniprot id: A0A0U5JEU1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

389348:PNK RS09765
gene id: 389348:PNK_RS09765
uniprot id: A0A0U5JHV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

389348:PNK RS10425
gene id: 389348:PNK_RS10425
uniprot id: A0A0U5JCW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

389348:PNK RS07160
gene id: 389348:PNK_RS07160
uniprot id: A0A0U5K4N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

389348:PNK RS01410
gene id: 389348:PNK_RS01410
uniprot id: A0A0U5EPS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

389348:PNK RS08535
gene id: 389348:PNK_RS08535
uniprot id: A0A0U5JCU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

389348:PNK RS08940
gene id: 389348:PNK_RS08940
uniprot id: A0A0U5JFN6
names: Similarity
messages: Belongs to the FMO family.

389348:PNK RS04615
gene id: 389348:PNK_RS04615
uniprot id: A0A0U5JDT3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS05665
gene id: 389348:PNK_RS05665
uniprot id: A0A0U5JAD4
names: Caution
names: Function
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
messages: Catalyzes the biosynthesis of agmatine from arginine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS03165
gene id: 389348:PNK_RS03165
uniprot id: A0A0U5CNN0
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

389348:PNK RS01300
gene id: 389348:PNK_RS01300
uniprot id: A0A0U5K1C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

389348:PNK RS07370
gene id: 389348:PNK_RS07370
uniprot id: A0A0U5JGP1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

389348:PNK RS08245
gene id: 389348:PNK_RS08245
uniprot id: A0A0U5JH38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

389348:PNK RS07075
gene id: 389348:PNK_RS07075
uniprot id: A0A0U5CQA8
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

389348:PNK RS07050
gene id: 389348:PNK_RS07050
uniprot id: A0A0U5JD02
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

389348:PNK RS01375
gene id: 389348:PNK_RS01375
uniprot id: A0A0U5JAS5
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

389348:PNK RS02100
gene id: 389348:PNK_RS02100
uniprot id: A0A0U5JDU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

389348:PNK RS07425
gene id: 389348:PNK_RS07425
uniprot id: A0A0U5ESA3
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

389348:PNK RS03075
gene id: 389348:PNK_RS03075
uniprot id: A0A0U5J838
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

389348:PNK RS09760
gene id: 389348:PNK_RS09760
uniprot id: A0A0U5JFJ0
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

389348:PNK RS01010
gene id: 389348:PNK_RS01010
uniprot id: A0A0U5EPB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Membrane

389348:PNK RS03315
gene id: 389348:PNK_RS03315
uniprot id: A0A0U5JBV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

389348:PNK RS06915
gene id: 389348:PNK_RS06915
uniprot id: A0A0U5CQ85
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

389348:PNK RS09440
gene id: 389348:PNK_RS09440
uniprot id: A0A0U5JI93
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS00320
gene id: 389348:PNK_RS00320
uniprot id: A0A0U5JD43
names: Similarity
messages: Belongs to the ParB family.

389348:PNK RS08765
gene id: 389348:PNK_RS08765
uniprot id: A0A0U5JG57
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS07395
gene id: 389348:PNK_RS07395
uniprot id: A0A0U5JE54
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

389348:PNK RS00720
gene id: 389348:PNK_RS00720
uniprot id: A0A0U5JDD4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

389348:PNK RS06775
gene id: 389348:PNK_RS06775
uniprot id: A0A0U5ES39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

389348:PNK RS08260
gene id: 389348:PNK_RS08260
uniprot id: A0A0U5JBN1
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.

389348:PNK RS06660
gene id: 389348:PNK_RS06660
uniprot id: A0A0U5JCX2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

389348:PNK RS06920
gene id: 389348:PNK_RS06920
uniprot id: A0A0U5JD24
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

389348:PNK RS02175
gene id: 389348:PNK_RS02175
uniprot id: A0A0U5JDW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

389348:PNK RS11850
gene id: 389348:PNK_RS11850
uniprot id: A0A0U5EUQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpA family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

389348:PNK RS09305
gene id: 389348:PNK_RS09305
uniprot id: A0A0U5K5S5
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.

389348:PNK RS12060
gene id: 389348:PNK_RS12060
uniprot id: A0A0U5JDH5
names: Similarity
messages: Belongs to the AAA ATPase family.

389348:PNK RS05440
gene id: 389348:PNK_RS05440
uniprot id: A0A0U5JD16
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

389348:PNK RS11320
gene id: 389348:PNK_RS11320
uniprot id: A0A0U5JGC9
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

389348:PNK RS11285
gene id: 389348:PNK_RS11285
uniprot id: A0A0U5JFG8
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

389348:PNK RS01965
gene id: 389348:PNK_RS01965
uniprot id: A0A0U5K1R9
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

389348:PNK RS10670
gene id: 389348:PNK_RS10670
uniprot id: A0A0U5JIC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm

389348:PNK RS06730
gene id: 389348:PNK_RS06730
uniprot id: A0A0U5JAW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched chain amino acid transporter family.
messages: Membrane

389348:PNK RS09850
gene id: 389348:PNK_RS09850
uniprot id: A0A0U5JIH0
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS03685
gene id: 389348:PNK_RS03685
uniprot id: A0A0U5JEQ4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

389348:PNK RS05255
gene id: 389348:PNK_RS05255
uniprot id: A0A0U5JD13
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS05620
gene id: 389348:PNK_RS05620
uniprot id: A0A0U5JBF4
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS08700
gene id: 389348:PNK_RS08700
uniprot id: A0A0U5ET68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

389348:PNK RS04725
gene id: 389348:PNK_RS04725
uniprot id: A0A0U5JFR1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

389348:PNK RS07150
gene id: 389348:PNK_RS07150
uniprot id: A0A0U5JAJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

389348:PNK RS06135
gene id: 389348:PNK_RS06135
uniprot id: A0A0U5JCK3
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS01680
gene id: 389348:PNK_RS01680
uniprot id: A0A0U5JDX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cytoplasm

389348:PNK RS01055
gene id: 389348:PNK_RS01055
uniprot id: A0A0U5J703
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

389348:PNK RS03065
gene id: 389348:PNK_RS03065
uniprot id: A0A0U5JAV8
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS04730
gene id: 389348:PNK_RS04730
uniprot id: A0A0U5JBT2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

389348:PNK RS08190
gene id: 389348:PNK_RS08190
uniprot id: A0A0U5JEL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

389348:PNK RS03810
gene id: 389348:PNK_RS03810
uniprot id: A0A0U5CNX8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

389348:PNK RS08240
gene id: 389348:PNK_RS08240
uniprot id: A0A0U5JEP5
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS09710
gene id: 389348:PNK_RS09710
uniprot id: A0A0U5JFF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

389348:PNK RS03235
gene id: 389348:PNK_RS03235
uniprot id: A0A0U5JBT9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS07880
gene id: 389348:PNK_RS07880
uniprot id: A0A0U5CQN4
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

389348:PNK RS10265
gene id: 389348:PNK_RS10265
uniprot id: A0A0U5JCS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

389348:PNK RS01170
gene id: 389348:PNK_RS01170
uniprot id: A0A0U5EPC6
names: Similarity
messages: Belongs to the IspF family.

389348:PNK RS09865
gene id: 389348:PNK_RS09865
uniprot id: A0A0U5JC31
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

389348:PNK RS05875
gene id: 389348:PNK_RS05875
uniprot id: A0A0U5JDY9
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS02615
gene id: 389348:PNK_RS02615
uniprot id: A0A0U5K235
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

389348:PNK RS02800
gene id: 389348:PNK_RS02800
uniprot id: A0A0U5JBX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

389348:PNK RS05570
gene id: 389348:PNK_RS05570
uniprot id: A0A0U5JD77
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

389348:PNK RS08020
gene id: 389348:PNK_RS08020
uniprot id: A0A0U5JBI9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

389348:PNK RS00015
gene id: 389348:PNK_RS00015
uniprot id: A0A0U5J6G8
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

389348:PNK RS04450
gene id: 389348:PNK_RS04450
uniprot id: A0A0U5JDQ5
names: Similarity
messages: Belongs to the Skp family.

389348:PNK RS03050
gene id: 389348:PNK_RS03050
uniprot id: A0A0U5JBS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

389348:PNK RS00160
gene id: 389348:PNK_RS00160
uniprot id: A0A0U5JD12
names: Similarity
messages: Belongs to the heme oxygenase family.

389348:PNK RS06990
gene id: 389348:PNK_RS06990
uniprot id: A0A0U5K4K7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

389348:PNK RS07960
gene id: 389348:PNK_RS07960
uniprot id: A0A0U5CQQ1
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

389348:PNK RS11570
gene id: 389348:PNK_RS11570
uniprot id: A0A0U5JJE0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS00680
gene id: 389348:PNK_RS00680
uniprot id: A0A0U5J8N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

389348:PNK RS11725
gene id: 389348:PNK_RS11725
uniprot id: A0A0U5JJ06
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

389348:PNK RS01430
gene id: 389348:PNK_RS01430
uniprot id: A0A0U5JDH7
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS03530
gene id: 389348:PNK_RS03530
uniprot id: A0A0U5J977
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

389348:PNK RS01435
gene id: 389348:PNK_RS01435
uniprot id: A0A0U5JDT1
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS03875
gene id: 389348:PNK_RS03875
uniprot id: A0A0U5JC68
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS04590
gene id: 389348:PNK_RS04590
uniprot id: A0A0U5JCJ5
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

389348:PNK RS01950
gene id: 389348:PNK_RS01950
uniprot id: A0A0U5J8D1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

389348:PNK RS04610
gene id: 389348:PNK_RS04610
uniprot id: A0A0U5JAV0
names: Cofactor
names: Similarity
messages: Belongs to the ApbE family.
messages: Magnesium. Can also use manganese.

389348:PNK RS07465
gene id: 389348:PNK_RS07465
uniprot id: A0A0U5JE72
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

389348:PNK RS11260
gene id: 389348:PNK_RS11260
uniprot id: A0A0U5JDB5
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

389348:PNK RS00305
gene id: 389348:PNK_RS00305
uniprot id: A0A0U5JA89
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm

389348:PNK RS00065
gene id: 389348:PNK_RS00065
uniprot id: A0A0U5JAG7
names: Similarity
messages: Belongs to the acylphosphatase family.

389348:PNK RS02485
gene id: 389348:PNK_RS02485
uniprot id: A0A0U5EQ58
names: Similarity
messages: Belongs to the UPF0310 family.

389348:PNK RS02240
gene id: 389348:PNK_RS02240
uniprot id: A0A0U5EQ40
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

389348:PNK RS04345
gene id: 389348:PNK_RS04345
uniprot id: A0A0U5K328
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS03300
gene id: 389348:PNK_RS03300
uniprot id: A0A0U5JB04
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Membrane

389348:PNK RS11855
gene id: 389348:PNK_RS11855
uniprot id: A0A0U5EUZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

389348:PNK RS04095
gene id: 389348:PNK_RS04095
uniprot id: A0A0U5JFD3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

389348:PNK RS01635
gene id: 389348:PNK_RS01635
uniprot id: A0A0U5JA72
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

389348:PNK RS09695
gene id: 389348:PNK_RS09695
uniprot id: A0A0U5JEI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

389348:PNK RS12855
gene id: 389348:PNK_RS12855
uniprot id: A0A0U5EVK3
names: Similarity
messages: Belongs to the ParA family.

389348:PNK RS06945
gene id: 389348:PNK_RS06945
uniprot id: A0A0U5JEJ5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

389348:PNK RS09640
gene id: 389348:PNK_RS09640
uniprot id: A0A0U5CRD2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

389348:PNK RS10520
gene id: 389348:PNK_RS10520
uniprot id: A0A0U5JCX8
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

389348:PNK RS11730
gene id: 389348:PNK_RS11730
uniprot id: A0A0U5JJH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

389348:PNK RS11505
gene id: 389348:PNK_RS11505
uniprot id: A0A0U5JGA8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

389348:PNK RS00835
gene id: 389348:PNK_RS00835
uniprot id: A0A0U5J9Q8
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

389348:PNK RS08210
gene id: 389348:PNK_RS08210
uniprot id: A0A0U5JCN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

389348:PNK RS10900
gene id: 389348:PNK_RS10900
uniprot id: A0A0U5JGR4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic Ku family.
messages: Homodimer. Interacts with LigD.
messages: With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.

389348:PNK RS06760
gene id: 389348:PNK_RS06760
uniprot id: A0A0U5JC17
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS1 family.
messages: Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.

389348:PNK RS09920
gene id: 389348:PNK_RS09920
uniprot id: A0A0U5JG64
names: Similarity
messages: Belongs to the thioredoxin family.

389348:PNK RS08670
gene id: 389348:PNK_RS08670
uniprot id: A0A0U5K5G4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

389348:PNK RS01820
gene id: 389348:PNK_RS01820
uniprot id: A0A0U5EPL0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Monomer.

389348:PNK RS09670
gene id: 389348:PNK_RS09670
uniprot id: A0A0U5JG17
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

389348:PNK RS09770
gene id: 389348:PNK_RS09770
uniprot id: A0A0U5JIF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

389348:PNK RS00685
gene id: 389348:PNK_RS00685
uniprot id: A0A0U5JBN0
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS09880
gene id: 389348:PNK_RS09880
uniprot id: A0A0U5CRI6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS06685
gene id: 389348:PNK_RS06685
uniprot id: A0A0U5JF00
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

389348:PNK RS11425
gene id: 389348:PNK_RS11425
uniprot id: A0A0U5JG92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

389348:PNK RS11090
gene id: 389348:PNK_RS11090
uniprot id: A0A0U5JCV8
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS11325
gene id: 389348:PNK_RS11325
uniprot id: A0A0U5JIS9
names: Similarity
messages: Belongs to the glycosyl hydrolase 63 family.

389348:PNK RS02445
gene id: 389348:PNK_RS02445
uniprot id: A0A0U5J7R5
names: Similarity
messages: Belongs to the ArsC family.

389348:PNK RS01580
gene id: 389348:PNK_RS01580
uniprot id: A0A0U5EPV6
names: Similarity
messages: Belongs to the AlaDH/PNT family.

389348:PNK RS03490
gene id: 389348:PNK_RS03490
uniprot id: A0A0U5EQB3
names: Similarity
messages: Belongs to the Nudix hydrolase family.

389348:PNK RS04485
gene id: 389348:PNK_RS04485
uniprot id: A0A0U5JFK7
names: Similarity
messages: Belongs to the fabD family.

389348:PNK RS07800
gene id: 389348:PNK_RS07800
uniprot id: A0A0U5JDJ6
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

389348:PNK RS08655
gene id: 389348:PNK_RS08655
uniprot id: A0A0U5JBV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

389348:PNK RS06055
gene id: 389348:PNK_RS06055
uniprot id: A0A0U5JCI9
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Monomer.

389348:PNK RS12030
gene id: 389348:PNK_RS12030
uniprot id: A0A0U5JGS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

389348:PNK RS10515
gene id: 389348:PNK_RS10515
uniprot id: A0A0U5JEX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Mediates magnesium influx to the cytosol.
messages: Membrane

389348:PNK RS03070
gene id: 389348:PNK_RS03070
uniprot id: A0A0U5J8Y9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS02090
gene id: 389348:PNK_RS02090
uniprot id: A0A0U5EPT9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

389348:PNK RS02325
gene id: 389348:PNK_RS02325
uniprot id: A0A0U5EQ45
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

389348:PNK RS11025
gene id: 389348:PNK_RS11025
uniprot id: A0A0U5CS31
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

389348:PNK RS08205
gene id: 389348:PNK_RS08205
uniprot id: A0A0U5JDS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

389348:PNK RS09345
gene id: 389348:PNK_RS09345
uniprot id: A0A0U5ETA4
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

389348:PNK RS09665
gene id: 389348:PNK_RS09665
uniprot id: A0A0U5ETM8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

389348:PNK RS01785
gene id: 389348:PNK_RS01785
uniprot id: A0A0U5K1N6
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

389348:PNK RS05660
gene id: 389348:PNK_RS05660
uniprot id: A0A0U5JCB3
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

389348:PNK RS01480
gene id: 389348:PNK_RS01480
uniprot id: A0A0U5J925
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

389348:PNK RS07555
gene id: 389348:PNK_RS07555
uniprot id: A0A0U5CQI2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

389348:PNK RS09360
gene id: 389348:PNK_RS09360
uniprot id: A0A0U5JI75
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS02330
gene id: 389348:PNK_RS02330
uniprot id: A0A0U5JBN4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS01285
gene id: 389348:PNK_RS01285
uniprot id: A0A0U5J808
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADP/ATP translocase tlc family.
messages: Membrane

389348:PNK RS03840
gene id: 389348:PNK_RS03840
uniprot id: A0A0U5JCL5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

389348:PNK RS09810
gene id: 389348:PNK_RS09810
uniprot id: A0A0U5JDI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

389348:PNK RS03865
gene id: 389348:PNK_RS03865
uniprot id: A0A0U5J9D2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

389348:PNK RS05925
gene id: 389348:PNK_RS05925
uniprot id: A0A0U5CPV6
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS01165
gene id: 389348:PNK_RS01165
uniprot id: A0A0U5JBW9
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

389348:PNK RS09150
gene id: 389348:PNK_RS09150
uniprot id: A0A0U5K5P6
names: Similarity
messages: Belongs to the UPF0235 family.

389348:PNK RS10440
gene id: 389348:PNK_RS10440
uniprot id: A0A0U5K6C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

389348:PNK RS02745
gene id: 389348:PNK_RS02745
uniprot id: A0A0U5J8T5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

389348:PNK RS08905
gene id: 389348:PNK_RS08905
uniprot id: A0A0U5K5K4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

389348:PNK RS02590
gene id: 389348:PNK_RS02590
uniprot id: A0A0U5JEF1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

389348:PNK RS09410
gene id: 389348:PNK_RS09410
uniprot id: A0A0U5ETG8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

389348:PNK RS07015
gene id: 389348:PNK_RS07015
uniprot id: A0A0U5ES59
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

389348:PNK RS09635
gene id: 389348:PNK_RS09635
uniprot id: A0A0U5K5Y6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

389348:PNK RS10750
gene id: 389348:PNK_RS10750
uniprot id: A0A0U5EU05
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

389348:PNK RS08935
gene id: 389348:PNK_RS08935
uniprot id: A0A0U5ETA9
names: Similarity
messages: Belongs to the Dps family.

389348:PNK RS08155
gene id: 389348:PNK_RS08155
uniprot id: A0A0U5ESM8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

389348:PNK RS04205
gene id: 389348:PNK_RS04205
uniprot id: A0A0U5JDK4
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

389348:PNK RS04275
gene id: 389348:PNK_RS04275
uniprot id: A0A0U5JBL0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

389348:PNK RS07315
gene id: 389348:PNK_RS07315
uniprot id: A0A0U5JE36
names: Similarity
messages: Belongs to the serpin family.

389348:PNK RS09160
gene id: 389348:PNK_RS09160
uniprot id: A0A0U5JD60
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

389348:PNK RS08770
gene id: 389348:PNK_RS08770
uniprot id: A0A0U5ESZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S9C family.
messages: Periplasm

389348:PNK RS01090
gene id: 389348:PNK_RS01090
uniprot id: A0A0U5JBV4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

389348:PNK RS01405
gene id: 389348:PNK_RS01405
uniprot id: A0A0U5EPG2
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS00110
gene id: 389348:PNK_RS00110
uniprot id: A0A0U5K0N0
names: Subunit
messages: Homodimer.

389348:PNK RS03650
gene id: 389348:PNK_RS03650
uniprot id: A0A0U5JD95
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

389348:PNK RS05600
gene id: 389348:PNK_RS05600
uniprot id: A0A0U5JD56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

389348:PNK RS00370
gene id: 389348:PNK_RS00370
uniprot id: A0A0U5EP40
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

389348:PNK RS11660
gene id: 389348:PNK_RS11660
uniprot id: A0A0U5JGE1
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS11225
gene id: 389348:PNK_RS11225
uniprot id: A0A0U5EUJ9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

389348:PNK RS07995
gene id: 389348:PNK_RS07995
uniprot id: A0A0U5ESK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

389348:PNK RS04930
gene id: 389348:PNK_RS04930
uniprot id: A0A0U5JB17
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

389348:PNK RS08000
gene id: 389348:PNK_RS08000
uniprot id: A0A0U5JEJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Membrane

389348:PNK RS08045
gene id: 389348:PNK_RS08045
uniprot id: A0A0U5JDP2
names: Similarity
messages: Belongs to the pyruvate kinase family.

389348:PNK RS06850
gene id: 389348:PNK_RS06850
uniprot id: A0A0U5ES44
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

389348:PNK RS00260
gene id: 389348:PNK_RS00260
uniprot id: A0A0U5JA04
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

389348:PNK RS07355
gene id: 389348:PNK_RS07355
uniprot id: A0A0U5JES4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

389348:PNK RS04805
gene id: 389348:PNK_RS04805
uniprot id: A0A0U5JFT1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

389348:PNK RS02135
gene id: 389348:PNK_RS02135
uniprot id: A0A0U5CN53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

389348:PNK RS10545
gene id: 389348:PNK_RS10545
uniprot id: A0A0U5JF23
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS10795
gene id: 389348:PNK_RS10795
uniprot id: A0A0U5CRY6
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

389348:PNK RS05755
gene id: 389348:PNK_RS05755
uniprot id: A0A0U5JD87
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

389348:PNK RS00020
gene id: 389348:PNK_RS00020
uniprot id: S4TLB8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS07185
gene id: 389348:PNK_RS07185
uniprot id: A0A0U5ES80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

389348:PNK RS12245
gene id: 389348:PNK_RS12245
uniprot id: A0A0U5JEW9
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

389348:PNK RS00225
gene id: 389348:PNK_RS00225
uniprot id: A0A0U5EP44
names: Subunit
messages: Homodimer.

389348:PNK RS03055
gene id: 389348:PNK_RS03055
uniprot id: A0A0U5JEC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

389348:PNK RS06725
gene id: 389348:PNK_RS06725
uniprot id: A0A0U5JCU7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS10030
gene id: 389348:PNK_RS10030
uniprot id: A0A0U5JCM9
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

389348:PNK RS07595
gene id: 389348:PNK_RS07595
uniprot id: A0A0U5JEB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

389348:PNK RS05610
gene id: 389348:PNK_RS05610
uniprot id: A0A0U5CPQ8
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

389348:PNK RS11560
gene id: 389348:PNK_RS11560
uniprot id: A0A0U5JGH7
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

389348:PNK RS07520
gene id: 389348:PNK_RS07520
uniprot id: A0A0U5JGR8
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

389348:PNK RS07405
gene id: 389348:PNK_RS07405
uniprot id: A0A0U5CQF3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

389348:PNK RS04395
gene id: 389348:PNK_RS04395
uniprot id: A0A0U5JCI7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flotillin-like FloA family.
messages: Cell membrane
messages: Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.
messages: Homooligomerizes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane raft

389348:PNK RS06120
gene id: 389348:PNK_RS06120
uniprot id: A0A0U5JDK0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Long' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

389348:PNK RS08805
gene id: 389348:PNK_RS08805
uniprot id: A0A0U5JE04
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

389348:PNK RS10155
gene id: 389348:PNK_RS10155
uniprot id: A0A0U5ETV8
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

389348:PNK RS10170
gene id: 389348:PNK_RS10170
uniprot id: A0A0U5JFR5
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

389348:PNK RS04325
gene id: 389348:PNK_RS04325
uniprot id: A0A0U5JBJ8
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS07785
gene id: 389348:PNK_RS07785
uniprot id: A0A0U5JAW9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
messages: Binds 1 NADP(+) per subunit.
messages: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
messages: Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
messages: Homopentamer.

389348:PNK RS06890
gene id: 389348:PNK_RS06890
uniprot id: A0A0U5JCX4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

389348:PNK RS10790
gene id: 389348:PNK_RS10790
uniprot id: A0A0U5K6I8
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

389348:PNK RS08490
gene id: 389348:PNK_RS08490
uniprot id: A0A0U5JDT6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

389348:PNK RS00465
gene id: 389348:PNK_RS00465
uniprot id: A0A0U5EP88
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NqrA family.
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

389348:PNK RS00715
gene id: 389348:PNK_RS00715
uniprot id: A0A0U5JD46
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

389348:PNK RS05285
gene id: 389348:PNK_RS05285
uniprot id: A0A0U5JCY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

389348:PNK RS03605
gene id: 389348:PNK_RS03605
uniprot id: A0A0U5JF28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

389348:PNK RS07695
gene id: 389348:PNK_RS07695
uniprot id: A0A0U5JDC9
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

389348:PNK RS09060
gene id: 389348:PNK_RS09060
uniprot id: A0A0U5JF36
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

389348:PNK RS06720
gene id: 389348:PNK_RS06720
uniprot id: A0A0U5JGR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm

389348:PNK RS02935
gene id: 389348:PNK_RS02935
uniprot id: A0A0U5J9Y0
names: Similarity
messages: Belongs to the DEAD box helicase family.

389348:PNK RS10975
gene id: 389348:PNK_RS10975
uniprot id: A0A0U5JGS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

389348:PNK RS03755
gene id: 389348:PNK_RS03755
uniprot id: A0A0U5JCJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

389348:PNK RS03545
gene id: 389348:PNK_RS03545
uniprot id: A0A0U5K2L1
names: Similarity
messages: Belongs to the Dps family.

389348:PNK RS11605
gene id: 389348:PNK_RS11605
uniprot id: A0A0U5JEJ3
names: Similarity
messages: Belongs to the UDPGP type 1 family.

389348:PNK RS06460
gene id: 389348:PNK_RS06460
uniprot id: A0A0U5JA90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

389348:PNK RS10160
gene id: 389348:PNK_RS10160
uniprot id: A0A0U5JGB1
names: Function
names: Similarity
messages: Belongs to the HMBS family.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.

389348:PNK RS06985
gene id: 389348:PNK_RS06985
uniprot id: A0A0U5JDX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

389348:PNK RS10415
gene id: 389348:PNK_RS10415
uniprot id: A0A0U5JIR9
names: Function
names: Similarity
messages: Belongs to the histone H1/H5 family. HCT subfamily.
messages: Might have a role analogous to that of eukaryotic histone proteins.

389348:PNK RS03955
gene id: 389348:PNK_RS03955
uniprot id: A0A0U5J8M6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

389348:PNK RS07580
gene id: 389348:PNK_RS07580
uniprot id: A0A0U5ESK3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

389348:PNK RS04635
gene id: 389348:PNK_RS04635
uniprot id: A0A0U5EQX6
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

389348:PNK RS01005
gene id: 389348:PNK_RS01005
uniprot id: A0A0U5JBT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliR/MopE/SpaR family.
messages: Membrane

389348:PNK RS01975
gene id: 389348:PNK_RS01975
uniprot id: A0A0U5JAC6
names: Similarity
messages: Belongs to the polysaccharide synthase family.

389348:PNK RS08695
gene id: 389348:PNK_RS08695
uniprot id: A0A0U5ESX2
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

389348:PNK RS11490
gene id: 389348:PNK_RS11490
uniprot id: A0A0U5JJD5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

389348:PNK RS08185
gene id: 389348:PNK_RS08185
uniprot id: A0A0U5JB39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

389348:PNK RS00840
gene id: 389348:PNK_RS00840
uniprot id: A0A0U5J8Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

389348:PNK RS08680
gene id: 389348:PNK_RS08680
uniprot id: A0A0U5JE17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

389348:PNK RS00875
gene id: 389348:PNK_RS00875
uniprot id: A0A0U5JD75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

389348:PNK RS04960
gene id: 389348:PNK_RS04960
uniprot id: A0A0U5ER40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

389348:PNK RS00300
gene id: 389348:PNK_RS00300
uniprot id: A0A0U5EP62
names: Similarity
messages: Belongs to the DprA/Smf family.

389348:PNK RS08505
gene id: 389348:PNK_RS08505
uniprot id: A0A0U5JES9
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

389348:PNK RS08140
gene id: 389348:PNK_RS08140
uniprot id: A0A0U5ESP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

389348:PNK RS01255
gene id: 389348:PNK_RS01255
uniprot id: A0A0U5JB32
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS10365
gene id: 389348:PNK_RS10365
uniprot id: A0A0U5CRS6
names: Similarity
messages: Belongs to the heat shock protein 90 family.

389348:PNK RS01850
gene id: 389348:PNK_RS01850
uniprot id: A0A0U5JE10
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

389348:PNK RS02015
gene id: 389348:PNK_RS02015
uniprot id: A0A0U5JDT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A probable RNA-binding protein.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm

389348:PNK RS03805
gene id: 389348:PNK_RS03805
uniprot id: A0A0U5K2Q9
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

389348:PNK RS10410
gene id: 389348:PNK_RS10410
uniprot id: A0A0U5JI88
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

389348:PNK RS00480
gene id: 389348:PNK_RS00480
uniprot id: A0A0U5J9F8
names: Similarity
messages: Belongs to the bacterial secretin family.

389348:PNK RS03020
gene id: 389348:PNK_RS03020
uniprot id: A0A0U5JCX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

389348:PNK RS06145
gene id: 389348:PNK_RS06145
uniprot id: A0A0U5JA11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

389348:PNK RS02635
gene id: 389348:PNK_RS02635
uniprot id: A0A0U5JCP9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

389348:PNK RS07550
gene id: 389348:PNK_RS07550
uniprot id: A0A0U5K4V7
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

389348:PNK RS12185
gene id: 389348:PNK_RS12185
uniprot id: A0A0U5JHG8
names: Similarity
messages: Belongs to the alkylbase DNA glycosidase AlkA family.

389348:PNK RS09705
gene id: 389348:PNK_RS09705
uniprot id: A0A0U5JBZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

389348:PNK RS09660
gene id: 389348:PNK_RS09660
uniprot id: A0A0U5ETJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

389348:PNK RS07295
gene id: 389348:PNK_RS07295
uniprot id: A0A0U5JH23
names: Similarity
messages: Belongs to the Nudix hydrolase family.

389348:PNK RS11500
gene id: 389348:PNK_RS11500
uniprot id: A0A0U5JD44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

389348:PNK RS09185
gene id: 389348:PNK_RS09185
uniprot id: A0A0U5JFU2
names: Similarity
messages: Belongs to the phD/YefM antitoxin family.

389348:PNK RS04430
gene id: 389348:PNK_RS04430
uniprot id: A0A0U5K343
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

389348:PNK RS08160
gene id: 389348:PNK_RS08160
uniprot id: A0A0U5JEN0
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Type III sulfatase family.

389348:PNK RS09070
gene id: 389348:PNK_RS09070
uniprot id: A0A0U5CR60
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

389348:PNK RS05565
gene id: 389348:PNK_RS05565
uniprot id: A0A0U5ERC1
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS11170
gene id: 389348:PNK_RS11170
uniprot id: A0A0U5JF98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

389348:PNK RS09190
gene id: 389348:PNK_RS09190
uniprot id: A0A0U5ET77
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

389348:PNK RS09470
gene id: 389348:PNK_RS09470
uniprot id: A0A0U5CRB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

389348:PNK RS08675
gene id: 389348:PNK_RS08675
uniprot id: A0A0U5CR20
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

389348:PNK RS04040
gene id: 389348:PNK_RS04040
uniprot id: A0A0U5JC87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

389348:PNK RS09600
gene id: 389348:PNK_RS09600
uniprot id: A0A0U5JFF1
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

389348:PNK RS04700
gene id: 389348:PNK_RS04700
uniprot id: A0A0U5ER44
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS04560
gene id: 389348:PNK_RS04560
uniprot id: A0A0U5JCM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

389348:PNK RS04645
gene id: 389348:PNK_RS04645
uniprot id: A0A0U5JF99
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

389348:PNK RS01100
gene id: 389348:PNK_RS01100
uniprot id: A0A0U5EPN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

389348:PNK RS01555
gene id: 389348:PNK_RS01555
uniprot id: A0A0U5JA61
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS01320
gene id: 389348:PNK_RS01320
uniprot id: A0A0U5JC01
names: Similarity
messages: Belongs to the peptidase S41A family.

389348:PNK RS06335
gene id: 389348:PNK_RS06335
uniprot id: A0A0U5CQ12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

389348:PNK RS08895
gene id: 389348:PNK_RS08895
uniprot id: A0A0U5JBI4
names: Similarity
messages: Belongs to the nitroreductase family. HadB/RutE subfamily.

389348:PNK RS07560
gene id: 389348:PNK_RS07560
uniprot id: A0A0U5JDE4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

389348:PNK RS08665
gene id: 389348:PNK_RS08665
uniprot id: A0A0U5JEV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

389348:PNK RS12780
gene id: 389348:PNK_RS12780
uniprot id: A0A0U5JIB2
names: Function
names: Similarity
messages: Belongs to the transposase mutator family.
messages: Required for the transposition of the insertion element.

389348:PNK RS01665
gene id: 389348:PNK_RS01665
uniprot id: A0A0U5EPN6
names: Similarity
messages: Belongs to the FliN/MopA/SpaO family.

389348:PNK RS01390
gene id: 389348:PNK_RS01390
uniprot id: A0A0U5JA28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

389348:PNK RS04425
gene id: 389348:PNK_RS04425
uniprot id: A0A0U5JCG3
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

389348:PNK RS02115
gene id: 389348:PNK_RS02115
uniprot id: A0A0U5J8G0
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

389348:PNK RS09610
gene id: 389348:PNK_RS09610
uniprot id: A0A0U5JIC6
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

389348:PNK RS01625
gene id: 389348:PNK_RS01625
uniprot id: A0A0U5K1L0
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS07705
gene id: 389348:PNK_RS07705
uniprot id: A0A0U5JAU2
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.

389348:PNK RS11635
gene id: 389348:PNK_RS11635
uniprot id: A0A0U5JIY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

389348:PNK RS08745
gene id: 389348:PNK_RS08745
uniprot id: A0A0U5K5I0
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

389348:PNK RS07080
gene id: 389348:PNK_RS07080
uniprot id: A0A0U5JD54
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

389348:PNK RS02280
gene id: 389348:PNK_RS02280
uniprot id: A0A0U5J8I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

389348:PNK RS10675
gene id: 389348:PNK_RS10675
uniprot id: A0A0U5JF09
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

389348:PNK RS12265
gene id: 389348:PNK_RS12265
uniprot id: A0A0U5JHI6
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS07900
gene id: 389348:PNK_RS07900
uniprot id: A0A0U5ESL2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

389348:PNK RS02225
gene id: 389348:PNK_RS02225
uniprot id: A0A0U5JCI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

389348:PNK RS02655
gene id: 389348:PNK_RS02655
uniprot id: A0A0U5EQ04
names: Function
names: Similarity
messages: Belongs to the peptidase M16 family.
messages: Endopeptidase that degrades small peptides of less than 7 kDa, such as glucagon and insulin.

389348:PNK RS04675
gene id: 389348:PNK_RS04675
uniprot id: A0A0U5K390
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

389348:PNK RS01365
gene id: 389348:PNK_RS01365
uniprot id: A0A0U5J821
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

389348:PNK RS07670
gene id: 389348:PNK_RS07670
uniprot id: A0A0U5JEY2
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

389348:PNK RS02180
gene id: 389348:PNK_RS02180
uniprot id: A0A0U5JE80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

389348:PNK RS01120
gene id: 389348:PNK_RS01120
uniprot id: A0A0U5JDM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

389348:PNK RS04835
gene id: 389348:PNK_RS04835
uniprot id: A0A0U5CPF1
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS04085
gene id: 389348:PNK_RS04085
uniprot id: A0A0U5JCB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

389348:PNK RS03335
gene id: 389348:PNK_RS03335
uniprot id: A0A0U5JA52
names: Similarity
messages: Belongs to the peptidase C59 family.

389348:PNK RS04540
gene id: 389348:PNK_RS04540
uniprot id: A0A0U5EQU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

389348:PNK RS07680
gene id: 389348:PNK_RS07680
uniprot id: A0A0U5JED4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

389348:PNK RS11435
gene id: 389348:PNK_RS11435
uniprot id: A0A0U5CSA1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

389348:PNK RS04335
gene id: 389348:PNK_RS04335
uniprot id: A0A0U5J8X3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

389348:PNK RS08565
gene id: 389348:PNK_RS08565
uniprot id: A0A0U5JEV5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

389348:PNK RS05030
gene id: 389348:PNK_RS05030
uniprot id: A0A0U5ER78
names: Similarity
messages: Belongs to the DEAD box helicase family.

389348:PNK RS04575
gene id: 389348:PNK_RS04575
uniprot id: A0A0U5JBQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

389348:PNK RS03145
gene id: 389348:PNK_RS03145
uniprot id: A0A0U5J904
names: Similarity
messages: Belongs to the glutamine synthetase family.

389348:PNK RS11565
gene id: 389348:PNK_RS11565
uniprot id: A0A0U5JIW9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type II sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.

389348:PNK RS02595
gene id: 389348:PNK_RS02595
uniprot id: A0A0U5JAJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Membrane

389348:PNK RS10550
gene id: 389348:PNK_RS10550
uniprot id: A0A0U5JDY3
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

389348:PNK RS01230
gene id: 389348:PNK_RS01230
uniprot id: A0A0U5CMQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

389348:PNK RS06860
gene id: 389348:PNK_RS06860
uniprot id: A0A0U5ES64
names: Similarity
messages: Belongs to the ClpA/ClpB family.

389348:PNK RS03940
gene id: 389348:PNK_RS03940
uniprot id: A0A0U5JF94
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

389348:PNK RS01345
gene id: 389348:PNK_RS01345
uniprot id: A0A0U5JAU3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

389348:PNK RS09530
gene id: 389348:PNK_RS09530
uniprot id: A0A0U5JCD2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS00675
gene id: 389348:PNK_RS00675
uniprot id: A0A0U5J9L4
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. TreS subfamily.

389348:PNK RS11575
gene id: 389348:PNK_RS11575
uniprot id: A0A0U5JFH8
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS01875
gene id: 389348:PNK_RS01875
uniprot id: A0A0U5K1Q5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

389348:PNK RS04480
gene id: 389348:PNK_RS04480
uniprot id: A0A0U5JF65
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

389348:PNK RS03450
gene id: 389348:PNK_RS03450
uniprot id: A0A0U5JEZ1
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS07420
gene id: 389348:PNK_RS07420
uniprot id: A0A0U5JFD4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

389348:PNK RS07925
gene id: 389348:PNK_RS07925
uniprot id: A0A0U5JGZ0
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.

389348:PNK RS09430
gene id: 389348:PNK_RS09430
uniprot id: A0A0U5JFC3
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

389348:PNK RS01045
gene id: 389348:PNK_RS01045
uniprot id: A0A0U5J9S6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

389348:PNK RS09620
gene id: 389348:PNK_RS09620
uniprot id: A0A0U5JCE8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

389348:PNK RS02735
gene id: 389348:PNK_RS02735
uniprot id: A0A0U5JEI5
names: Function
names: Similarity
messages: Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

389348:PNK RS07455
gene id: 389348:PNK_RS07455
uniprot id: A0A0U5JD78
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

389348:PNK RS10090
gene id: 389348:PNK_RS10090
uniprot id: A0A0U5JFP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

389348:PNK RS03895
gene id: 389348:PNK_RS03895
uniprot id: A0A0U5JBD3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

389348:PNK RS03000
gene id: 389348:PNK_RS03000
uniprot id: A0A0U5K2A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

389348:PNK RS10525
gene id: 389348:PNK_RS10525
uniprot id: A0A0U5JCI8
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

389348:PNK RS01425
gene id: 389348:PNK_RS01425
uniprot id: A0A0U5JAW3
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS08685
gene id: 389348:PNK_RS08685
uniprot id: A0A0U5JCX7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the complex I 75 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

389348:PNK RS10935
gene id: 389348:PNK_RS10935
uniprot id: A0A0U5JG16
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS10405
gene id: 389348:PNK_RS10405
uniprot id: A0A0U5JFW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

389348:PNK RS08495
gene id: 389348:PNK_RS08495
uniprot id: A0A0U5JBS6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

389348:PNK RS05320
gene id: 389348:PNK_RS05320
uniprot id: A0A0U5ERC3
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

389348:PNK RS00630
gene id: 389348:PNK_RS00630
uniprot id: A0A0U5JAG4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

389348:PNK RS03995
gene id: 389348:PNK_RS03995
uniprot id: S4TLB6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

389348:PNK RS10825
gene id: 389348:PNK_RS10825
uniprot id: A0A0U5JG15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

389348:PNK RS03180
gene id: 389348:PNK_RS03180
uniprot id: A0A0U5JD08
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

389348:PNK RS01490
gene id: 389348:PNK_RS01490
uniprot id: A0A0U5EPH5
names: Similarity
messages: Belongs to the peptidase C40 family.

389348:PNK RS04850
gene id: 389348:PNK_RS04850
uniprot id: A0A0U5JDY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 30 subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

389348:PNK RS09115
gene id: 389348:PNK_RS09115
uniprot id: A0A0U5JHI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

389348:PNK RS09220
gene id: 389348:PNK_RS09220
uniprot id: A0A0U5JF64
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

389348:PNK RS07470
gene id: 389348:PNK_RS07470
uniprot id: A0A0U5K4U2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS04975
gene id: 389348:PNK_RS04975
uniprot id: A0A0U5JFW6
names: Similarity
messages: Belongs to the pirin family.

389348:PNK RS08660
gene id: 389348:PNK_RS08660
uniprot id: A0A0U5JBD5
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS08710
gene id: 389348:PNK_RS08710
uniprot id: A0A0U5ESZ4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

389348:PNK RS02930
gene id: 389348:PNK_RS02930
uniprot id: A0A0U5JAW6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

389348:PNK RS03375
gene id: 389348:PNK_RS03375
uniprot id: A0A0U5JB19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

389348:PNK RS06445
gene id: 389348:PNK_RS06445
uniprot id: A0A0U5JG88
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS04795
gene id: 389348:PNK_RS04795
uniprot id: A0A0U5JCS6
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS08340
gene id: 389348:PNK_RS08340
uniprot id: A0A0U5JB71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

389348:PNK RS09775
gene id: 389348:PNK_RS09775
uniprot id: A0A0U5JEJ6
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

389348:PNK RS02765
gene id: 389348:PNK_RS02765
uniprot id: A0A0U5CNG5
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

389348:PNK RS00970
gene id: 389348:PNK_RS00970
uniprot id: A0A0U5J7U9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

389348:PNK RS01190
gene id: 389348:PNK_RS01190
uniprot id: A0A0U5JAR5
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

389348:PNK RS02750
gene id: 389348:PNK_RS02750
uniprot id: A0A0U5J7X3
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

389348:PNK RS11295
gene id: 389348:PNK_RS11295
uniprot id: A0A0U5JHG1
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

389348:PNK RS00640
gene id: 389348:PNK_RS00640
uniprot id: A0A0U5JDA6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

389348:PNK RS00955
gene id: 389348:PNK_RS00955
uniprot id: A0A0U5JD91
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

389348:PNK RS01340
gene id: 389348:PNK_RS01340
uniprot id: A0A0U5EPK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADP/ATP translocase tlc family.
messages: Membrane

389348:PNK RS02975
gene id: 389348:PNK_RS02975
uniprot id: A0A0U5JEB3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

389348:PNK RS01495
gene id: 389348:PNK_RS01495
uniprot id: A0A0U5EPU2
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

389348:PNK RS03640
gene id: 389348:PNK_RS03640
uniprot id: A0A0U5JB94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

389348:PNK RS02875
gene id: 389348:PNK_RS02875
uniprot id: A0A0U5JBZ6
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

389348:PNK RS10660
gene id: 389348:PNK_RS10660
uniprot id: A0A0U5EU00
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

389348:PNK RS07340
gene id: 389348:PNK_RS07340
uniprot id: A0A0U5JFC0
names: Similarity
messages: Belongs to the Nudix hydrolase family.

389348:PNK RS11740
gene id: 389348:PNK_RS11740
uniprot id: A0A0U5JDA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

389348:PNK RS12590
gene id: 389348:PNK_RS12590
uniprot id: A0A0U5JK09
names: Similarity
messages: Belongs to the EUO family.

389348:PNK RS00825
gene id: 389348:PNK_RS00825
uniprot id: A0A0U5K117
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS00550
gene id: 389348:PNK_RS00550
uniprot id: A0A0U5JAF1
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

389348:PNK RS01125
gene id: 389348:PNK_RS01125
uniprot id: A0A0U5J9T9
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

389348:PNK RS11005
gene id: 389348:PNK_RS11005
uniprot id: A0A0U5JD69
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

389348:PNK RS00140
gene id: 389348:PNK_RS00140
uniprot id: A0A0U5JAI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

389348:PNK RS10345
gene id: 389348:PNK_RS10345
uniprot id: A0A0U5JCU2
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS11670
gene id: 389348:PNK_RS11670
uniprot id: A0A0U5CSE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

389348:PNK RS00965
gene id: 389348:PNK_RS00965
uniprot id: A0A0U5J9P3
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

389348:PNK RS07035
gene id: 389348:PNK_RS07035
uniprot id: A0A0U5JE12
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS03610
gene id: 389348:PNK_RS03610
uniprot id: A0A0U5JB61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

389348:PNK RS06040
gene id: 389348:PNK_RS06040
uniprot id: A0A0U5ERP6
names: Similarity
messages: Belongs to the UPF0166 family.

389348:PNK RS08715
gene id: 389348:PNK_RS08715
uniprot id: A0A0U5JEY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

389348:PNK RS10180
gene id: 389348:PNK_RS10180
uniprot id: A0A0U5JIN1
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

389348:PNK RS08605
gene id: 389348:PNK_RS08605
uniprot id: A0A0U5JCW4
names: Similarity
messages: Belongs to the MYG1 family.

389348:PNK RS08545
gene id: 389348:PNK_RS08545
uniprot id: A0A0U5ESV4
names: Similarity
messages: Belongs to the SufE family.

389348:PNK RS09700
gene id: 389348:PNK_RS09700
uniprot id: A0A0U5JCF9
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

389348:PNK RS11405
gene id: 389348:PNK_RS11405
uniprot id: A0A0U5JJC0
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

389348:PNK RS04280
gene id: 389348:PNK_RS04280
uniprot id: A0A0U5JAN1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

389348:PNK RS11355
gene id: 389348:PNK_RS11355
uniprot id: A0A0U5K6T8
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS05985
gene id: 389348:PNK_RS05985
uniprot id: A0A0U5JAJ4
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS03600
gene id: 389348:PNK_RS03600
uniprot id: A0A0U5JEN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

389348:PNK RS00785
gene id: 389348:PNK_RS00785
uniprot id: A0A0U5EPD4
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

389348:PNK RS04640
gene id: 389348:PNK_RS04640
uniprot id: A0A0U5JCP2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

389348:PNK RS11530
gene id: 389348:PNK_RS11530
uniprot id: A0A0U5JHL4
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS02530
gene id: 389348:PNK_RS02530
uniprot id: A0A0U5JBE6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS09370
gene id: 389348:PNK_RS09370
uniprot id: A0A0U5JEB5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

389348:PNK RS06375
gene id: 389348:PNK_RS06375
uniprot id: A0A0U5JCP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

389348:PNK RS01015
gene id: 389348:PNK_RS01015
uniprot id: A0A0U5EPM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliP/MopC/SpaP family.
messages: Membrane

389348:PNK RS07495
gene id: 389348:PNK_RS07495
uniprot id: A0A0U5ESD2
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

389348:PNK RS04455
gene id: 389348:PNK_RS04455
uniprot id: A0A0U5EQT3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

389348:PNK RS10175
gene id: 389348:PNK_RS10175
uniprot id: A0A0U5JI29
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

389348:PNK RS07180
gene id: 389348:PNK_RS07180
uniprot id: A0A0U5JF92
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS04565
gene id: 389348:PNK_RS04565
uniprot id: A0A0U5JF83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

389348:PNK RS10290
gene id: 389348:PNK_RS10290
uniprot id: A0A0U5JEX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched chain amino acid transporter family.
messages: Membrane

389348:PNK RS08930
gene id: 389348:PNK_RS08930
uniprot id: A0A0U5ET51
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

389348:PNK RS08840
gene id: 389348:PNK_RS08840
uniprot id: A0A0U5JD04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

389348:PNK RS10190
gene id: 389348:PNK_RS10190
uniprot id: A0A0U5JCQ9
names: Similarity
messages: Belongs to the EUO family.

389348:PNK RS00910
gene id: 389348:PNK_RS00910
uniprot id: A0A0U5CMK8
names: Similarity
messages: Belongs to the ABC transporter superfamily.

389348:PNK RS01845
gene id: 389348:PNK_RS01845
uniprot id: A0A0U5JDQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

389348:PNK RS01960
gene id: 389348:PNK_RS01960
uniprot id: A0A0U5JB34
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

389348:PNK RS03305
gene id: 389348:PNK_RS03305
uniprot id: A0A0U5J927
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
messages: Heterooctamer of two A chains, two B chains, two C chains and two D chains.
messages: Membrane

389348:PNK RS04765
gene id: 389348:PNK_RS04765
uniprot id: A0A0U5JAY1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS04495
gene id: 389348:PNK_RS04495
uniprot id: A0A0U5J9R5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

389348:PNK RS00600
gene id: 389348:PNK_RS00600
uniprot id: A0A0U5J8L3
names: Similarity
messages: Belongs to the peptidase M24B family.

389348:PNK RS10785
gene id: 389348:PNK_RS10785
uniprot id: A0A0U5JFY9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

389348:PNK RS11290
gene id: 389348:PNK_RS11290
uniprot id: A0A0U5JEC4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

389348:PNK RS08795
gene id: 389348:PNK_RS08795
uniprot id: A0A0U5JHD3
names: Subcellular Location Annotation
messages: Membrane

389348:PNK RS09645
gene id: 389348:PNK_RS09645
uniprot id: A0A0U5JEJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

389348:PNK RS03270
gene id: 389348:PNK_RS03270
uniprot id: A0A0U5EQF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell membrane

389348:PNK RS01335
gene id: 389348:PNK_RS01335
uniprot id: A0A0U5JB48
names: Similarity
messages: Belongs to the RecJ family.

389348:PNK RS08120
gene id: 389348:PNK_RS08120
uniprot id: A0A0U5CQS9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

389348:PNK RS09325
gene id: 389348:PNK_RS09325
uniprot id: A0A0U5JGF8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

389348:PNK RS03320
gene id: 389348:PNK_RS03320
uniprot id: A0A0U5K2G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Cell membrane
messages: Membrane

389348:PNK RS04705
gene id: 389348:PNK_RS04705
uniprot id: A0A0U5JD67
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

389348:PNK RS01220
gene id: 389348:PNK_RS01220
uniprot id: A0A0U5JAP1
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

389348:PNK RS07700
gene id: 389348:PNK_RS07700
uniprot id: A0A0U5JBC9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

389348:PNK RS11580
gene id: 389348:PNK_RS11580
uniprot id: A0A0U5JDH0
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

389348:PNK RS05540
gene id: 389348:PNK_RS05540
uniprot id: A0A0U5JBE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane