384616:PISL RS06235
gene id: 384616:PISL_RS06235
uniprot id: A1RTU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

384616:PISL RS08155
gene id: 384616:PISL_RS08155
uniprot id: A1RUV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

384616:PISL RS08690
gene id: 384616:PISL_RS08690
uniprot id: A1RV63
names: Similarity
messages: Belongs to the RuvB family.

384616:PISL RS02330
gene id: 384616:PISL_RS02330
uniprot id: A1RRQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

384616:PISL RS05625
gene id: 384616:PISL_RS05625
uniprot id: A1RTI4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

384616:PISL RS09240
gene id: 384616:PISL_RS09240
uniprot id: A1RVG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

384616:PISL RS09365
gene id: 384616:PISL_RS09365
uniprot id: A1RVJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.

384616:PISL RS02725
gene id: 384616:PISL_RS02725
uniprot id: A1RRX6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.

384616:PISL RS09270
gene id: 384616:PISL_RS09270
uniprot id: A1RVH3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

384616:PISL RS08790
gene id: 384616:PISL_RS08790
uniprot id: A1RV83
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Heterooctamer of four alpha and four beta chains arranged as a tetramer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.
messages: Specifically catalyzes the decarboxylation of L-arginine to agmatine. Has no S-adenosylmethionine decarboxylase (AdoMetDC) activity.

384616:PISL RS05415
gene id: 384616:PISL_RS05415
uniprot id: A1RTE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane

384616:PISL RS03515
gene id: 384616:PISL_RS03515
uniprot id: A1RSC7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

384616:PISL RS02430
gene id: 384616:PISL_RS02430
uniprot id: A1RRS0
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS08175
gene id: 384616:PISL_RS08175
uniprot id: A1RUW1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

384616:PISL RS06865
gene id: 384616:PISL_RS06865
uniprot id: A1RU68
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

384616:PISL RS00550
gene id: 384616:PISL_RS00550
uniprot id: A1RQQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

384616:PISL RS02275
gene id: 384616:PISL_RS02275
uniprot id: A1RRP0
names: Subcellular Location Annotation
messages: Nucleus

384616:PISL RS06300
gene id: 384616:PISL_RS06300
uniprot id: A1RTV9
names: Similarity
messages: Belongs to the AOR/FOR family.

384616:PISL RS09185
gene id: 384616:PISL_RS09185
uniprot id: A1RVF6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

384616:PISL RS07395
gene id: 384616:PISL_RS07395
uniprot id: A1RUG8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

384616:PISL RS03505
gene id: 384616:PISL_RS03505
uniprot id: A1RSC5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

384616:PISL RS04135
gene id: 384616:PISL_RS04135
uniprot id: A1RSP7
names: Similarity
messages: Belongs to the UPF0173 family.

384616:PISL RS08125
gene id: 384616:PISL_RS08125
uniprot id: A1RUV1
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

384616:PISL RS00270
gene id: 384616:PISL_RS00270
uniprot id: A1RQK4
names: Function
names: Similarity
messages: Belongs to the FAU-1 family.
messages: Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.

384616:PISL RS09405
gene id: 384616:PISL_RS09405
uniprot id: A1RVJ9
names: Similarity
messages: Belongs to the DMRL synthase family.

384616:PISL RS06070
gene id: 384616:PISL_RS06070
uniprot id: A1RTR7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

384616:PISL RS06705
gene id: 384616:PISL_RS06705
uniprot id: A1RU36
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

384616:PISL RS00100
gene id: 384616:PISL_RS00100
uniprot id: A1RQH0
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase.

384616:PISL RS01670
gene id: 384616:PISL_RS01670
uniprot id: A1RRC0
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

384616:PISL RS09890
gene id: 384616:PISL_RS09890
uniprot id: A1RVT4
names: Similarity
messages: Belongs to the UPF0248 family.

384616:PISL RS08035
gene id: 384616:PISL_RS08035
uniprot id: A1RUT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

384616:PISL RS02455
gene id: 384616:PISL_RS02455
uniprot id: A1RRS5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

384616:PISL RS02910
gene id: 384616:PISL_RS02910
uniprot id: A1RS12
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

384616:PISL RS03405
gene id: 384616:PISL_RS03405
uniprot id: A1RSA5
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

384616:PISL RS08475
gene id: 384616:PISL_RS08475
uniprot id: A1RV20
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

384616:PISL RS02370
gene id: 384616:PISL_RS02370
uniprot id: A1RRQ8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

384616:PISL RS03615
gene id: 384616:PISL_RS03615
uniprot id: A1RSE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

384616:PISL RS00525
gene id: 384616:PISL_RS00525
uniprot id: A1RQQ0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

384616:PISL RS04295
gene id: 384616:PISL_RS04295
uniprot id: A1RSS8
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.
messages: Binds 1 zinc ion per subunit.

384616:PISL RS07730
gene id: 384616:PISL_RS07730
uniprot id: A1RUM9
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

384616:PISL RS06240
gene id: 384616:PISL_RS06240
uniprot id: A1RTV0
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.

384616:PISL RS09265
gene id: 384616:PISL_RS09265
uniprot id: A1RVH2
names: Similarity
messages: Belongs to the peptidase S8 family.

384616:PISL RS05050
gene id: 384616:PISL_RS05050
uniprot id: A1RT72
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS03145
gene id: 384616:PISL_RS03145
uniprot id: A1RS55
names: Subcellular Location Annotation
messages: Cell membrane

384616:PISL RS05575
gene id: 384616:PISL_RS05575
uniprot id: A1RTH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

384616:PISL RS09075
gene id: 384616:PISL_RS09075
uniprot id: A1RVD2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

384616:PISL RS00850
gene id: 384616:PISL_RS00850
uniprot id: A1RQW6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

384616:PISL RS08745
gene id: 384616:PISL_RS08745
uniprot id: A1RV74
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

384616:PISL RS04365
gene id: 384616:PISL_RS04365
uniprot id: A1RSU1
names: Similarity
messages: Belongs to the complex I subunit 3 family.

384616:PISL RS03915
gene id: 384616:PISL_RS03915
uniprot id: A1RSK3
names: Similarity
messages: Belongs to the UPF0210 family.

384616:PISL RS02755
gene id: 384616:PISL_RS02755
uniprot id: A1RRY2
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

384616:PISL RS09555
gene id: 384616:PISL_RS09555
uniprot id: A1RVM6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

384616:PISL RS07380
gene id: 384616:PISL_RS07380
uniprot id: A1RUG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

384616:PISL RS00315
gene id: 384616:PISL_RS00315
uniprot id: A1RQL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

384616:PISL RS01330
gene id: 384616:PISL_RS01330
uniprot id: A1RR54
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

384616:PISL RS09225
gene id: 384616:PISL_RS09225
uniprot id: A1RVG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

384616:PISL RS02040
gene id: 384616:PISL_RS02040
uniprot id: A1RRJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

384616:PISL RS05915
gene id: 384616:PISL_RS05915
uniprot id: A1RTP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

384616:PISL RS09900
gene id: 384616:PISL_RS09900
uniprot id: A1RVT6
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.

384616:PISL RS09660
gene id: 384616:PISL_RS09660
uniprot id: A1RVP3
names: Similarity
messages: Belongs to the SfsA family.

384616:PISL RS01440
gene id: 384616:PISL_RS01440
uniprot id: A1RR74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. LysZ subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).

384616:PISL RS06460
gene id: 384616:PISL_RS06460
uniprot id: A1RTY9
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

384616:PISL RS03025
gene id: 384616:PISL_RS03025
uniprot id: A1RS34
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

384616:PISL RS01200
gene id: 384616:PISL_RS01200
uniprot id: A1RR30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

384616:PISL RS05235
gene id: 384616:PISL_RS05235
uniprot id: A1RTA7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

384616:PISL RS05680
gene id: 384616:PISL_RS05680
uniprot id: A1RTJ3
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

384616:PISL RS06280
gene id: 384616:PISL_RS06280
uniprot id: A1RTV6
names: Subunit
messages: Homodimer.

384616:PISL RS05885
gene id: 384616:PISL_RS05885
uniprot id: A1RTN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

384616:PISL RS05665
gene id: 384616:PISL_RS05665
uniprot id: A1RTJ0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

384616:PISL RS09885
gene id: 384616:PISL_RS09885
uniprot id: A1RVT3
names: Similarity
messages: Belongs to the TrpF family.

384616:PISL RS09100
gene id: 384616:PISL_RS09100
uniprot id: A1RVD8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

384616:PISL RS00280
gene id: 384616:PISL_RS00280
uniprot id: A1RQK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

384616:PISL RS03545
gene id: 384616:PISL_RS03545
uniprot id: A1RSD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

384616:PISL RS03630
gene id: 384616:PISL_RS03630
uniprot id: A1RSF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

384616:PISL RS08935
gene id: 384616:PISL_RS08935
uniprot id: A1RVB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

384616:PISL RS09785
gene id: 384616:PISL_RS09785
uniprot id: A1RVR4
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS01110
gene id: 384616:PISL_RS01110
uniprot id: A1RR15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

384616:PISL RS09305
gene id: 384616:PISL_RS09305
uniprot id: A1RVI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

384616:PISL RS03555
gene id: 384616:PISL_RS03555
uniprot id: A1RSD4
names: Similarity
messages: Belongs to the UPF0179 family.

384616:PISL RS04950
gene id: 384616:PISL_RS04950
uniprot id: A1RT52
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

384616:PISL RS04575
gene id: 384616:PISL_RS04575
uniprot id: A1RSY3
names: Similarity
messages: Belongs to the flavin oxidoreductase frp family.

384616:PISL RS09125
gene id: 384616:PISL_RS09125
uniprot id: A1RVE2
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

384616:PISL RS03675
gene id: 384616:PISL_RS03675
uniprot id: Q9UWR5
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

384616:PISL RS02070
gene id: 384616:PISL_RS02070
uniprot id: A1RRK1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

384616:PISL RS08845
gene id: 384616:PISL_RS08845
uniprot id: A1RV93
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.

384616:PISL RS09590
gene id: 384616:PISL_RS09590
uniprot id: A1RVN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

384616:PISL RS01635
gene id: 384616:PISL_RS01635
uniprot id: A1RRB3
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS09230
gene id: 384616:PISL_RS09230
uniprot id: A1RVG5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

384616:PISL RS01780
gene id: 384616:PISL_RS01780
uniprot id: A1RRE2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

384616:PISL RS00660
gene id: 384616:PISL_RS00660
uniprot id: A1RQS8
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS04695
gene id: 384616:PISL_RS04695
uniprot id: A1RT04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

384616:PISL RS09725
gene id: 384616:PISL_RS09725
uniprot id: A1RVQ3
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

384616:PISL RS01285
gene id: 384616:PISL_RS01285
uniprot id: A1RR45
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

384616:PISL RS08945
gene id: 384616:PISL_RS08945
uniprot id: A1RVB2
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

384616:PISL RS05900
gene id: 384616:PISL_RS05900
uniprot id: A1RTN7
names: Caution
names: Similarity
messages: Belongs to the acylphosphatase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

384616:PISL RS01180
gene id: 384616:PISL_RS01180
uniprot id: A1RR27
names: Similarity
messages: Belongs to the Mg-chelatase subunit H family.

384616:PISL RS04955
gene id: 384616:PISL_RS04955
uniprot id: A1RT53
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

384616:PISL RS08365
gene id: 384616:PISL_RS08365
uniprot id: A1RUZ8
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS08760
gene id: 384616:PISL_RS08760
uniprot id: A1RV77
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

384616:PISL RS06650
gene id: 384616:PISL_RS06650
uniprot id: A1RU25
names: Similarity
messages: Belongs to the acylphosphatase family.

384616:PISL RS05800
gene id: 384616:PISL_RS05800
uniprot id: A1RTL6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

384616:PISL RS01900
gene id: 384616:PISL_RS01900
uniprot id: A1RRG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

384616:PISL RS06400
gene id: 384616:PISL_RS06400
uniprot id: A1RTX8
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

384616:PISL RS01305
gene id: 384616:PISL_RS01305
uniprot id: A1RR49
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

384616:PISL RS09680
gene id: 384616:PISL_RS09680
uniprot id: A1RVP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

384616:PISL RS03810
gene id: 384616:PISL_RS03810
uniprot id: A1RSI5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.

384616:PISL RS01455
gene id: 384616:PISL_RS01455
uniprot id: A1RR78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

384616:PISL RS04860
gene id: 384616:PISL_RS04860
uniprot id: A1RT34
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).

384616:PISL RS00750
gene id: 384616:PISL_RS00750
uniprot id: A1RQU5
names: Similarity
messages: Belongs to the glutamine synthetase family.

384616:PISL RS01065
gene id: 384616:PISL_RS01065
uniprot id: A1RR06
names: Similarity
messages: Belongs to the HupF/HypC family.

384616:PISL RS08655
gene id: 384616:PISL_RS08655
uniprot id: A1RV56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

384616:PISL RS02365
gene id: 384616:PISL_RS02365
uniprot id: A1RRQ7
names: Subcellular Location Annotation
messages: Cell membrane

384616:PISL RS09760
gene id: 384616:PISL_RS09760
uniprot id: A1RVR0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

384616:PISL RS04690
gene id: 384616:PISL_RS04690
uniprot id: A1RT03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

384616:PISL RS04735
gene id: 384616:PISL_RS04735
uniprot id: A1RT12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

384616:PISL RS00405
gene id: 384616:PISL_RS00405
uniprot id: A1RQM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

384616:PISL RS04435
gene id: 384616:PISL_RS04435
uniprot id: A1RSV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

384616:PISL RS04595
gene id: 384616:PISL_RS04595
uniprot id: A1RSY7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers.

384616:PISL RS07200
gene id: 384616:PISL_RS07200
uniprot id: A1RUD1
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS06940
gene id: 384616:PISL_RS06940
uniprot id: A1RU82
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS04740
gene id: 384616:PISL_RS04740
uniprot id: A1RT13
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

384616:PISL RS04910
gene id: 384616:PISL_RS04910
uniprot id: A1RT44
names: Similarity
messages: Belongs to the class-I fumarase family.

384616:PISL RS09565
gene id: 384616:PISL_RS09565
uniprot id: A1RVM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DadA oxidoreductase family.
messages: Catalyzes the dehydrogenation of D-proline. Can also use other D-amino acids, but with lower efficiency.
messages: Cell membrane
messages: Homotetramer.

384616:PISL RS06110
gene id: 384616:PISL_RS06110
uniprot id: A1RTS5
names: Similarity
messages: Belongs to the MoaB/Mog family.

384616:PISL RS01675
gene id: 384616:PISL_RS01675
uniprot id: A1RRC1
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

384616:PISL RS04035
gene id: 384616:PISL_RS04035
uniprot id: A1RSM7
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

384616:PISL RS03080
gene id: 384616:PISL_RS03080
uniprot id: A1RS43
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

384616:PISL RS06760
gene id: 384616:PISL_RS06760
uniprot id: A1RU47
names: Similarity
messages: Belongs to the disproportionating enzyme family.

384616:PISL RS01705
gene id: 384616:PISL_RS01705
uniprot id: A1RRC7
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

384616:PISL RS03635
gene id: 384616:PISL_RS03635
uniprot id: A1RSF1
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

384616:PISL RS08105
gene id: 384616:PISL_RS08105
uniprot id: A1RUU8
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

384616:PISL RS04885
gene id: 384616:PISL_RS04885
uniprot id: A1RT39
names: Similarity
messages: Belongs to the Nth/MutY family.

384616:PISL RS09120
gene id: 384616:PISL_RS09120
uniprot id: A1RVE1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm

384616:PISL RS01370
gene id: 384616:PISL_RS01370
uniprot id: A1RR60
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase family.

384616:PISL RS07025
gene id: 384616:PISL_RS07025
uniprot id: A1RU98
names: Similarity
messages: Belongs to the UPF0284 family.

384616:PISL RS00530
gene id: 384616:PISL_RS00530
uniprot id: A1RQQ1
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

384616:PISL RS04730
gene id: 384616:PISL_RS04730
uniprot id: A1RT11
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

384616:PISL RS02375
gene id: 384616:PISL_RS02375
uniprot id: A1RRQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

384616:PISL RS00535
gene id: 384616:PISL_RS00535
uniprot id: A1RQQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

384616:PISL RS02915
gene id: 384616:PISL_RS02915
uniprot id: A1RS13
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

384616:PISL RS04985
gene id: 384616:PISL_RS04985
uniprot id: A1RT58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Membrane

384616:PISL RS05300
gene id: 384616:PISL_RS05300
uniprot id: A1RTC1
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

384616:PISL RS05580
gene id: 384616:PISL_RS05580
uniprot id: A1RTH4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

384616:PISL RS08305
gene id: 384616:PISL_RS08305
uniprot id: A1RUY8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

384616:PISL RS02245
gene id: 384616:PISL_RS02245
uniprot id: A1RRN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

384616:PISL RS08130
gene id: 384616:PISL_RS08130
uniprot id: A1RUV2
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

384616:PISL RS04390
gene id: 384616:PISL_RS04390
uniprot id: A1RSU6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

384616:PISL RS09675
gene id: 384616:PISL_RS09675
uniprot id: A1RVP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.

384616:PISL RS08375
gene id: 384616:PISL_RS08375
uniprot id: A1RV00
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS07405
gene id: 384616:PISL_RS07405
uniprot id: A1RUG9
names: Caution
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

384616:PISL RS00740
gene id: 384616:PISL_RS00740
uniprot id: A1RQU3
names: Similarity
messages: Belongs to the glutamate synthase family.

384616:PISL RS08480
gene id: 384616:PISL_RS08480
uniprot id: A1RV21
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS08680
gene id: 384616:PISL_RS08680
uniprot id: A1RV61
names: Similarity
messages: Belongs to the citrate synthase family.

384616:PISL RS01590
gene id: 384616:PISL_RS01590
uniprot id: A1RRA4
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

384616:PISL RS06225
gene id: 384616:PISL_RS06225
uniprot id: A1RTU7
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

384616:PISL RS03575
gene id: 384616:PISL_RS03575
uniprot id: A1RSD8
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

384616:PISL RS06990
gene id: 384616:PISL_RS06990
uniprot id: A1RU92
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

384616:PISL RS03035
gene id: 384616:PISL_RS03035
uniprot id: A1RS36
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS05860
gene id: 384616:PISL_RS05860
uniprot id: A1RTM9
names: Similarity
messages: Belongs to the Nth/MutY family.

384616:PISL RS02215
gene id: 384616:PISL_RS02215
uniprot id: A1RRM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

384616:PISL RS02195
gene id: 384616:PISL_RS02195
uniprot id: A1RRM4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

384616:PISL RS07155
gene id: 384616:PISL_RS07155
uniprot id: A1RUC2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family. LysK subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
messages: Cytoplasm

384616:PISL RS02395
gene id: 384616:PISL_RS02395
uniprot id: A1RRR3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

384616:PISL RS03645
gene id: 384616:PISL_RS03645
uniprot id: A1RSF3
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

384616:PISL RS07035
gene id: 384616:PISL_RS07035
uniprot id: A1RUA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.

384616:PISL RS03885
gene id: 384616:PISL_RS03885
uniprot id: A1RSJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

384616:PISL RS01970
gene id: 384616:PISL_RS01970
uniprot id: A1RRI1
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

384616:PISL RS02055
gene id: 384616:PISL_RS02055
uniprot id: A1RRJ8
names: Similarity
messages: Belongs to the NOP5/NOP56 family.

384616:PISL RS08460
gene id: 384616:PISL_RS08460
uniprot id: A1RV17
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

384616:PISL RS00115
gene id: 384616:PISL_RS00115
uniprot id: A1RQH3
names: Similarity
messages: Belongs to the UPF0282 family.

384616:PISL RS03650
gene id: 384616:PISL_RS03650
uniprot id: A1RSF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

384616:PISL RS09255
gene id: 384616:PISL_RS09255
uniprot id: A1RVH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

384616:PISL RS01575
gene id: 384616:PISL_RS01575
uniprot id: A1RRA1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

384616:PISL RS07080
gene id: 384616:PISL_RS07080
uniprot id: A1RUA9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

384616:PISL RS02700
gene id: 384616:PISL_RS02700
uniprot id: A1RRX1
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

384616:PISL RS03170
gene id: 384616:PISL_RS03170
uniprot id: A1RS60
names: Similarity
messages: Belongs to the glutaredoxin family.

384616:PISL RS02660
gene id: 384616:PISL_RS02660
uniprot id: A1RRW3
names: Similarity
messages: Belongs to the UPF0273 family.

384616:PISL RS00180
gene id: 384616:PISL_RS00180
uniprot id: A1RQI6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

384616:PISL RS04085
gene id: 384616:PISL_RS04085
uniprot id: A1RSN7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-67 and Arg-70) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.

384616:PISL RS05410
gene id: 384616:PISL_RS05410
uniprot id: A1RTE1
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

384616:PISL RS09320
gene id: 384616:PISL_RS09320
uniprot id: A1RVI3
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

384616:PISL RS03750
gene id: 384616:PISL_RS03750
uniprot id: A1RSH4
names: Similarity
messages: Belongs to the peptidase M24B family.

384616:PISL RS09535
gene id: 384616:PISL_RS09535
uniprot id: A1RVM2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

384616:PISL RS05690
gene id: 384616:PISL_RS05690
uniprot id: A1RTJ5
names: Similarity
messages: Belongs to the pyruvate kinase family.

384616:PISL RS06800
gene id: 384616:PISL_RS06800
uniprot id: A1RU55
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnC family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).

384616:PISL RS07755
gene id: 384616:PISL_RS07755
uniprot id: A1RUN3
names: Caution
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

384616:PISL RS01700
gene id: 384616:PISL_RS01700
uniprot id: A1RRC6
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

384616:PISL RS08955
gene id: 384616:PISL_RS08955
uniprot id: A1RVB4
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

384616:PISL RS06625
gene id: 384616:PISL_RS06625
uniprot id: A1RU20
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

384616:PISL RS02390
gene id: 384616:PISL_RS02390
uniprot id: A1RRR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

384616:PISL RS03700
gene id: 384616:PISL_RS03700
uniprot id: A1RSG4
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

384616:PISL RS02970
gene id: 384616:PISL_RS02970
uniprot id: A1RS24
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

384616:PISL RS00640
gene id: 384616:PISL_RS00640
uniprot id: A1RQS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
messages: Cell membrane

384616:PISL RS06740
gene id: 384616:PISL_RS06740
uniprot id: A1RU43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Cytoplasm
messages: Homodimer or homotetramer.

384616:PISL RS07275
gene id: 384616:PISL_RS07275
uniprot id: A1RUE4
names: Subcellular Location Annotation
messages: Encapsulin nanocompartment

384616:PISL RS03895
gene id: 384616:PISL_RS03895
uniprot id: A1RSJ9
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

384616:PISL RS09910
gene id: 384616:PISL_RS09910
uniprot id: A1RVT8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in both the arginine and lysine biosynthetic pathways.

384616:PISL RS06710
gene id: 384616:PISL_RS06710
uniprot id: A1RU37
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

384616:PISL RS05875
gene id: 384616:PISL_RS05875
uniprot id: A1RTN2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

384616:PISL RS09130
gene id: 384616:PISL_RS09130
uniprot id: A1RVE3
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

384616:PISL RS02020
gene id: 384616:PISL_RS02020
uniprot id: A1RRJ1
names: Similarity
messages: Belongs to the HerA family.

384616:PISL RS02945
gene id: 384616:PISL_RS02945
uniprot id: A1RS19
names: Similarity
messages: Belongs to the TFIIB family.

384616:PISL RS04200
gene id: 384616:PISL_RS04200
uniprot id: A1RSR0
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

384616:PISL RS01610
gene id: 384616:PISL_RS01610
uniprot id: A1RRA8
names: Similarity
messages: Belongs to the peptidase U62 family.

384616:PISL RS04965
gene id: 384616:PISL_RS04965
uniprot id: A1RT55
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

384616:PISL RS05805
gene id: 384616:PISL_RS05805
uniprot id: A1RTL7
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

384616:PISL RS09770
gene id: 384616:PISL_RS09770
uniprot id: A1RVR1
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS02555
gene id: 384616:PISL_RS02555
uniprot id: A1RRU4
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

384616:PISL RS03445
gene id: 384616:PISL_RS03445
uniprot id: A1RSB3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

384616:PISL RS09340
gene id: 384616:PISL_RS09340
uniprot id: A1RVI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

384616:PISL RS02600
gene id: 384616:PISL_RS02600
uniprot id: A1RRV1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

384616:PISL RS05375
gene id: 384616:PISL_RS05375
uniprot id: A1RTD5
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

384616:PISL RS03040
gene id: 384616:PISL_RS03040
uniprot id: A1RS37
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS08565
gene id: 384616:PISL_RS08565
uniprot id: A1RV38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

384616:PISL RS05045
gene id: 384616:PISL_RS05045
uniprot id: A1RT71
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS09840
gene id: 384616:PISL_RS09840
uniprot id: A1RVS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

384616:PISL RS07365
gene id: 384616:PISL_RS07365
uniprot id: A1RUG1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

384616:PISL RS03530
gene id: 384616:PISL_RS03530
uniprot id: A1RSD0
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

384616:PISL RS05700
gene id: 384616:PISL_RS05700
uniprot id: A1RTJ7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

384616:PISL RS05105
gene id: 384616:PISL_RS05105
uniprot id: A1RT81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

384616:PISL RS07930
gene id: 384616:PISL_RS07930
uniprot id: A1RUR7
names: Similarity
messages: Belongs to the CRISPR-associated Csm3 family.

384616:PISL RS03385
gene id: 384616:PISL_RS03385
uniprot id: A1RSA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

384616:PISL RS03570
gene id: 384616:PISL_RS03570
uniprot id: A1RSD7
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

384616:PISL RS09520
gene id: 384616:PISL_RS09520
uniprot id: A1RVL9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

384616:PISL RS06815
gene id: 384616:PISL_RS06815
uniprot id: A1RU58
names: Similarity
messages: Belongs to the UPF0045 family.

384616:PISL RS02355
gene id: 384616:PISL_RS02355
uniprot id: A1RRQ5
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

384616:PISL RS00880
gene id: 384616:PISL_RS00880
uniprot id: A1RQX2
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS06495
gene id: 384616:PISL_RS06495
uniprot id: A1RTZ6
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

384616:PISL RS02715
gene id: 384616:PISL_RS02715
uniprot id: A1RRX4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

384616:PISL RS07870
gene id: 384616:PISL_RS07870
uniprot id: A1RUQ5
names: Similarity
messages: Belongs to the HepT RNase toxin family.

384616:PISL RS05015
gene id: 384616:PISL_RS05015
uniprot id: A1RT65
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

384616:PISL RS03485
gene id: 384616:PISL_RS03485
uniprot id: A1RSC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

384616:PISL RS05745
gene id: 384616:PISL_RS05745
uniprot id: A1RTK6
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

384616:PISL RS02065
gene id: 384616:PISL_RS02065
uniprot id: A1RRK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

384616:PISL RS03140
gene id: 384616:PISL_RS03140
uniprot id: A1RS54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

384616:PISL RS02640
gene id: 384616:PISL_RS02640
uniprot id: A1RRV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

384616:PISL RS07725
gene id: 384616:PISL_RS07725
uniprot id: A1RUM8
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

384616:PISL RS00055
gene id: 384616:PISL_RS00055
uniprot id: A1RQG1
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS10290
gene id: 384616:PISL_RS10290
uniprot id: A1RW13
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.

384616:PISL RS06745
gene id: 384616:PISL_RS06745
uniprot id: A1RU44
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

384616:PISL RS02345
gene id: 384616:PISL_RS02345
uniprot id: A1RRQ3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

384616:PISL RS01695
gene id: 384616:PISL_RS01695
uniprot id: A1RRC5
names: Similarity
messages: Belongs to the complex I subunit 3 family.

384616:PISL RS07040
gene id: 384616:PISL_RS07040
uniprot id: A1RUA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

384616:PISL RS04805
gene id: 384616:PISL_RS04805
uniprot id: A1RT26
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

384616:PISL RS01020
gene id: 384616:PISL_RS01020
uniprot id: A1RQZ7
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

384616:PISL RS06995
gene id: 384616:PISL_RS06995
uniprot id: A1RU93
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

384616:PISL RS08440
gene id: 384616:PISL_RS08440
uniprot id: A1RV13
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

384616:PISL RS05540
gene id: 384616:PISL_RS05540
uniprot id: A1RTG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

384616:PISL RS08715
gene id: 384616:PISL_RS08715
uniprot id: A1RV68
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

384616:PISL RS08890
gene id: 384616:PISL_RS08890
uniprot id: A1RVA2
names: Subcellular Location Annotation
messages: Cell membrane

384616:PISL RS00855
gene id: 384616:PISL_RS00855
uniprot id: A1RQW7
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS06145
gene id: 384616:PISL_RS06145
uniprot id: A1RTT2
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

384616:PISL RS02255
gene id: 384616:PISL_RS02255
uniprot id: A1RRN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

384616:PISL RS09830
gene id: 384616:PISL_RS09830
uniprot id: A1RVS3
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

384616:PISL RS01350
gene id: 384616:PISL_RS01350
uniprot id: A1RR58
names: Similarity
messages: Belongs to the PstS family.

384616:PISL RS06015
gene id: 384616:PISL_RS06015
uniprot id: A1RTQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

384616:PISL RS00495
gene id: 384616:PISL_RS00495
uniprot id: A1RQP5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

384616:PISL RS02955
gene id: 384616:PISL_RS02955
uniprot id: A1RS21
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

384616:PISL RS00645
gene id: 384616:PISL_RS00645
uniprot id: A1RQS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

384616:PISL RS08085
gene id: 384616:PISL_RS08085
uniprot id: A1RUU3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

384616:PISL RS01100
gene id: 384616:PISL_RS01100
uniprot id: A1RR13
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS02880
gene id: 384616:PISL_RS02880
uniprot id: A1RS06
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

384616:PISL RS06425
gene id: 384616:PISL_RS06425
uniprot id: A1RTY2
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS03335
gene id: 384616:PISL_RS03335
uniprot id: A1RS91
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

384616:PISL RS09595
gene id: 384616:PISL_RS09595
uniprot id: A1RVN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

384616:PISL RS02350
gene id: 384616:PISL_RS02350
uniprot id: A1RRQ4
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

384616:PISL RS08810
gene id: 384616:PISL_RS08810
uniprot id: A1RV87
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

384616:PISL RS04625
gene id: 384616:PISL_RS04625
uniprot id: A1RSZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

384616:PISL RS00410
gene id: 384616:PISL_RS00410
uniprot id: A1RQM9
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS01485
gene id: 384616:PISL_RS01485
uniprot id: A1RR84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

384616:PISL RS09275
gene id: 384616:PISL_RS09275
uniprot id: A1RVH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.

384616:PISL RS07000
gene id: 384616:PISL_RS07000
uniprot id: A1RU94
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

384616:PISL RS04315
gene id: 384616:PISL_RS04315
uniprot id: A1RST2
names: Similarity
messages: Belongs to the SDO1/SBDS family.

384616:PISL RS08145
gene id: 384616:PISL_RS08145
uniprot id: A1RUV5
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

384616:PISL RS03980
gene id: 384616:PISL_RS03980
uniprot id: A1RSL5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

384616:PISL RS00915
gene id: 384616:PISL_RS00915
uniprot id: A1RQX7
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS01035
gene id: 384616:PISL_RS01035
uniprot id: A1RR00
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

384616:PISL RS10080
gene id: 384616:PISL_RS10080
uniprot id: A1RVX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

384616:PISL RS06595
gene id: 384616:PISL_RS06595
uniprot id: A1RU15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

384616:PISL RS09005
gene id: 384616:PISL_RS09005
uniprot id: A1RVC4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

384616:PISL RS03435
gene id: 384616:PISL_RS03435
uniprot id: A1RSB1
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs.

384616:PISL RS07190
gene id: 384616:PISL_RS07190
uniprot id: A1RUC9
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS04585
gene id: 384616:PISL_RS04585
uniprot id: A1RSY5
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

384616:PISL RS05110
gene id: 384616:PISL_RS05110
uniprot id: A1RT82
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane

384616:PISL RS06195
gene id: 384616:PISL_RS06195
uniprot id: A1RTU1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

384616:PISL RS00445
gene id: 384616:PISL_RS00445
uniprot id: A1RQN6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

384616:PISL RS02420
gene id: 384616:PISL_RS02420
uniprot id: A1RRR8
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

384616:PISL RS02760
gene id: 384616:PISL_RS02760
uniprot id: A1RRY3
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

384616:PISL RS05460
gene id: 384616:PISL_RS05460
uniprot id: A1RTF2
names: Similarity
messages: Belongs to the phosphohexose mutase family.

384616:PISL RS03560
gene id: 384616:PISL_RS03560
uniprot id: A1RSD5
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

384616:PISL RS00570
gene id: 384616:PISL_RS00570
uniprot id: A1RQQ9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

384616:PISL RS09805
gene id: 384616:PISL_RS09805
uniprot id: A1RVR8
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

384616:PISL RS06275
gene id: 384616:PISL_RS06275
uniprot id: A1RTV5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

384616:PISL RS06065
gene id: 384616:PISL_RS06065
uniprot id: A1RTR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

384616:PISL RS04060
gene id: 384616:PISL_RS04060
uniprot id: A1RSN2
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

384616:PISL RS01435
gene id: 384616:PISL_RS01435
uniprot id: A1RR73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways.

384616:PISL RS07855
gene id: 384616:PISL_RS07855
uniprot id: A1RUQ2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

384616:PISL RS05685
gene id: 384616:PISL_RS05685
uniprot id: A1RTJ4
names: Similarity
messages: Belongs to the MEMO1 family.

384616:PISL RS00650
gene id: 384616:PISL_RS00650
uniprot id: A1RQS5
names: Similarity
messages: Belongs to the TrpC family.

384616:PISL RS04310
gene id: 384616:PISL_RS04310
uniprot id: A1RST1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

384616:PISL RS06855
gene id: 384616:PISL_RS06855
uniprot id: A1RU66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

384616:PISL RS00860
gene id: 384616:PISL_RS00860
uniprot id: A1RQW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

384616:PISL RS03775
gene id: 384616:PISL_RS03775
uniprot id: A1RSH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

384616:PISL RS02035
gene id: 384616:PISL_RS02035
uniprot id: A1RRJ4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

384616:PISL RS02380
gene id: 384616:PISL_RS02380
uniprot id: A1RRR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

384616:PISL RS08040
gene id: 384616:PISL_RS08040
uniprot id: A1RUT4
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Tetramer of two alpha and two beta subunits.

384616:PISL RS03640
gene id: 384616:PISL_RS03640
uniprot id: A1RSF2
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

384616:PISL RS06125
gene id: 384616:PISL_RS06125
uniprot id: A1RTS8
names: Subcellular Location Annotation
messages: Nucleus

384616:PISL RS02005
gene id: 384616:PISL_RS02005
uniprot id: A1RRI8
names: Similarity
messages: Belongs to the type IA topoisomerase family.

384616:PISL RS07465
gene id: 384616:PISL_RS07465
uniprot id: A1RUI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Membrane

384616:PISL RS04610
gene id: 384616:PISL_RS04610
uniprot id: A1RSY9
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

384616:PISL RS05535
gene id: 384616:PISL_RS05535
uniprot id: A1RTG5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

384616:PISL RS02820
gene id: 384616:PISL_RS02820
uniprot id: A1RRZ5
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

384616:PISL RS02930
gene id: 384616:PISL_RS02930
uniprot id: A1RS16
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

384616:PISL RS00425
gene id: 384616:PISL_RS00425
uniprot id: A1RQN2
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS05290
gene id: 384616:PISL_RS05290
uniprot id: A1RTB9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

384616:PISL RS04040
gene id: 384616:PISL_RS04040
uniprot id: A1RSM8
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS06735
gene id: 384616:PISL_RS06735
uniprot id: A1RU41
names: Similarity
messages: Belongs to the peptidase S9C family.

384616:PISL RS09135
gene id: 384616:PISL_RS09135
uniprot id: A1RVE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

384616:PISL RS00655
gene id: 384616:PISL_RS00655
uniprot id: A1RQS6
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS02250
gene id: 384616:PISL_RS02250
uniprot id: A1RRN5
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

384616:PISL RS08785
gene id: 384616:PISL_RS08785
uniprot id: A1RV82
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.
messages: The N-terminal domain is an archaea-specific tRNA-editing domain that hydrolyzes incorrectly charged L-seryl-tRNA(Thr). Catalysis of tRNA editing is performed by the charged tRNA itself.

384616:PISL RS04300
gene id: 384616:PISL_RS04300
uniprot id: A1RSS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

384616:PISL RS09850
gene id: 384616:PISL_RS09850
uniprot id: A1RVS7
names: Function
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

384616:PISL RS10365
gene id: 384616:PISL_RS10365
uniprot id: A1RW28
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS05620
gene id: 384616:PISL_RS05620
uniprot id: A1RTI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).

384616:PISL RS06680
gene id: 384616:PISL_RS06680
uniprot id: A1RU31
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS06875
gene id: 384616:PISL_RS06875
uniprot id: A1RU70
names: Similarity
messages: In the C-terminal section; belongs to the trehalose phosphatase family.

384616:PISL RS04000
gene id: 384616:PISL_RS04000
uniprot id: A1RSL9
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer composed of an alpha and a beta subunit.
messages: Heterodimer of the IorA and IorB subunits.

384616:PISL RS03015
gene id: 384616:PISL_RS03015
uniprot id: A1RS32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

384616:PISL RS04620
gene id: 384616:PISL_RS04620
uniprot id: A1RSZ1
names: Similarity
messages: Belongs to the arginase family.

384616:PISL RS01680
gene id: 384616:PISL_RS01680
uniprot id: A1RRC2
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

384616:PISL RS01690
gene id: 384616:PISL_RS01690
uniprot id: A1RRC4
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS10320
gene id: 384616:PISL_RS10320
uniprot id: A1RW20
names: Similarity
messages: Belongs to the UPF0251 family.

384616:PISL RS08645
gene id: 384616:PISL_RS08645
uniprot id: A1RV54
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity).
messages: Belongs to the archease family.

384616:PISL RS03115
gene id: 384616:PISL_RS03115
uniprot id: A1RS49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

384616:PISL RS07540
gene id: 384616:PISL_RS07540
uniprot id: A1RUJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

384616:PISL RS03510
gene id: 384616:PISL_RS03510
uniprot id: A1RSC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

384616:PISL RS03990
gene id: 384616:PISL_RS03990
uniprot id: A1RSL7
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

384616:PISL RS03300
gene id: 384616:PISL_RS03300
uniprot id: A1RS86
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

384616:PISL RS03590
gene id: 384616:PISL_RS03590
uniprot id: A1RSE2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

384616:PISL RS01730
gene id: 384616:PISL_RS01730
uniprot id: A1RRD2
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

384616:PISL RS08835
gene id: 384616:PISL_RS08835
uniprot id: A1RV91
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

384616:PISL RS03390
gene id: 384616:PISL_RS03390
uniprot id: A1RSA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

384616:PISL RS08850
gene id: 384616:PISL_RS08850
uniprot id: A1RV94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

384616:PISL RS09870
gene id: 384616:PISL_RS09870
uniprot id: A1RVT1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

384616:PISL RS06215
gene id: 384616:PISL_RS06215
uniprot id: A1RTU5
names: Similarity
messages: Belongs to the ZPR1 family.

384616:PISL RS08330
gene id: 384616:PISL_RS08330
uniprot id: A1RUZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

384616:PISL RS02180
gene id: 384616:PISL_RS02180
uniprot id: A1RRM2
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

384616:PISL RS07820
gene id: 384616:PISL_RS07820
uniprot id: A1RUP6
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS07145
gene id: 384616:PISL_RS07145
uniprot id: A1RUC0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YjjX NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

384616:PISL RS02385
gene id: 384616:PISL_RS02385
uniprot id: A1RRR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

384616:PISL RS01935
gene id: 384616:PISL_RS01935
uniprot id: A1RRH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

384616:PISL RS03480
gene id: 384616:PISL_RS03480
uniprot id: A1RSC0
names: Similarity
messages: Belongs to the peptidase S8 family.

384616:PISL RS05490
gene id: 384616:PISL_RS05490
uniprot id: A1RTF7
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

384616:PISL RS09070
gene id: 384616:PISL_RS09070
uniprot id: A1RVD1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Reduced FMN (FMNH(2)).

384616:PISL RS02990
gene id: 384616:PISL_RS02990
uniprot id: A1RS28
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.

384616:PISL RS05920
gene id: 384616:PISL_RS05920
uniprot id: A1RTP1
names: Similarity
messages: Belongs to the MCM family.

384616:PISL RS03240
gene id: 384616:PISL_RS03240
uniprot id: A1RS74
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS08735
gene id: 384616:PISL_RS08735
uniprot id: A1RV72
names: Similarity
messages: Belongs to the PrpD family.

384616:PISL RS04145
gene id: 384616:PISL_RS04145
uniprot id: A1RSP9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

384616:PISL RS00415
gene id: 384616:PISL_RS00415
uniprot id: A1RQN0
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.

384616:PISL RS01050
gene id: 384616:PISL_RS01050
uniprot id: A1RR03
names: Similarity
messages: Belongs to the HypE family.

384616:PISL RS06255
gene id: 384616:PISL_RS06255
uniprot id: A1RTV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

384616:PISL RS05285
gene id: 384616:PISL_RS05285
uniprot id: A1RTB8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

384616:PISL RS02010
gene id: 384616:PISL_RS02010
uniprot id: A1RRI9
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

384616:PISL RS01480
gene id: 384616:PISL_RS01480
uniprot id: A1RR83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

384616:PISL RS05435
gene id: 384616:PISL_RS05435
uniprot id: A1RTE7
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS09200
gene id: 384616:PISL_RS09200
uniprot id: A1RVF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

384616:PISL RS02240
gene id: 384616:PISL_RS02240
uniprot id: A1RRN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).

384616:PISL RS06150
gene id: 384616:PISL_RS06150
uniprot id: A1RTT3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

384616:PISL RS04250
gene id: 384616:PISL_RS04250
uniprot id: A1RSR9
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

384616:PISL RS02220
gene id: 384616:PISL_RS02220
uniprot id: A1RRM8
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

384616:PISL RS08995
gene id: 384616:PISL_RS08995
uniprot id: A1RVC2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

384616:PISL RS03425
gene id: 384616:PISL_RS03425
uniprot id: A1RSA9
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

384616:PISL RS07835
gene id: 384616:PISL_RS07835
uniprot id: A1RUP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

384616:PISL RS02225
gene id: 384616:PISL_RS02225
uniprot id: A1RRM9
names: Similarity
messages: Belongs to the eIF-2-alpha family.

384616:PISL RS04750
gene id: 384616:PISL_RS04750
uniprot id: A1RT15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

384616:PISL RS03625
gene id: 384616:PISL_RS03625
uniprot id: A1RSE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

384616:PISL RS06775
gene id: 384616:PISL_RS06775
uniprot id: A1RU50
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

384616:PISL RS02560
gene id: 384616:PISL_RS02560
uniprot id: A1RRU5
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

384616:PISL RS01085
gene id: 384616:PISL_RS01085
uniprot id: A1RR10
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

384616:PISL RS02965
gene id: 384616:PISL_RS02965
uniprot id: A1RS23
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

384616:PISL RS10115
gene id: 384616:PISL_RS10115
uniprot id: A1RVX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsrC/TusE family.
messages: Cytoplasm

384616:PISL RS08775
gene id: 384616:PISL_RS08775
uniprot id: A1RV80
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

384616:PISL RS03610
gene id: 384616:PISL_RS03610
uniprot id: A1RSE6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

384616:PISL RS08665
gene id: 384616:PISL_RS08665
uniprot id: A1RV58
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm
messages: Homodimer.

384616:PISL RS01565
gene id: 384616:PISL_RS01565
uniprot id: A1RR99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

384616:PISL RS09865
gene id: 384616:PISL_RS09865
uniprot id: A1RVT0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

384616:PISL RS07840
gene id: 384616:PISL_RS07840
uniprot id: A1RUQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

384616:PISL RS02960
gene id: 384616:PISL_RS02960
uniprot id: A1RS22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

384616:PISL RS05100
gene id: 384616:PISL_RS05100
uniprot id: A1RT80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

384616:PISL RS02775
gene id: 384616:PISL_RS02775
uniprot id: A1RRY6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

384616:PISL RS02115
gene id: 384616:PISL_RS02115
uniprot id: A1RRL0
names: Similarity
messages: Belongs to the RutC family.

384616:PISL RS05570
gene id: 384616:PISL_RS05570
uniprot id: A1RTH1
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

384616:PISL RS06085
gene id: 384616:PISL_RS06085
uniprot id: A1RTS0
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

384616:PISL RS04230
gene id: 384616:PISL_RS04230
uniprot id: A1RSR6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

384616:PISL RS09755
gene id: 384616:PISL_RS09755
uniprot id: A1RVQ9
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

384616:PISL RS02535
gene id: 384616:PISL_RS02535
uniprot id: A1RRU0
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

384616:PISL RS01310
gene id: 384616:PISL_RS01310
uniprot id: A1RR50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 2 family.
messages: Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

384616:PISL RS05020
gene id: 384616:PISL_RS05020
uniprot id: A1RT66
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

384616:PISL RS02975
gene id: 384616:PISL_RS02975
uniprot id: A1RS25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

384616:PISL RS08220
gene id: 384616:PISL_RS08220
uniprot id: A1RUX0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.
messages: Belongs to the Cren7 family.
messages: Cytoplasm
messages: Methylated at multiple sites, to varying extents.
messages: Monomer.

384616:PISL RS04375
gene id: 384616:PISL_RS04375
uniprot id: A1RSU3
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

384616:PISL RS06635
gene id: 384616:PISL_RS06635
uniprot id: A1RU22
names: Similarity
messages: Belongs to the RimK family. LysX subfamily.

384616:PISL RS08865
gene id: 384616:PISL_RS08865
uniprot id: A1RV98
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

384616:PISL RS06335
gene id: 384616:PISL_RS06335
uniprot id: A1RTW6
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

384616:PISL RS03620
gene id: 384616:PISL_RS03620
uniprot id: A1RSE8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

384616:PISL RS01070
gene id: 384616:PISL_RS01070
uniprot id: A1RR07
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

384616:PISL RS10120
gene id: 384616:PISL_RS10120
uniprot id: A1RVX9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

384616:PISL RS08340
gene id: 384616:PISL_RS08340
uniprot id: A1RUZ4
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS08585
gene id: 384616:PISL_RS08585
uniprot id: A1RV42
names: Cofactor
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

384616:PISL RS03940
gene id: 384616:PISL_RS03940
uniprot id: A1RSK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

384616:PISL RS03580
gene id: 384616:PISL_RS03580
uniprot id: A1RSE0
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

384616:PISL RS05645
gene id: 384616:PISL_RS05645
uniprot id: A1RTI8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

384616:PISL RS00245
gene id: 384616:PISL_RS00245
uniprot id: A1RQJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

384616:PISL RS03525
gene id: 384616:PISL_RS03525
uniprot id: A1RSC9
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

384616:PISL RS00555
gene id: 384616:PISL_RS00555
uniprot id: A1RQQ6
names: Similarity
messages: Belongs to the SAICAR synthetase family.

384616:PISL RS02565
gene id: 384616:PISL_RS02565
uniprot id: A1RRU6
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

384616:PISL RS08860
gene id: 384616:PISL_RS08860
uniprot id: A1RV97
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

384616:PISL RS00465
gene id: 384616:PISL_RS00465
uniprot id: A1RQN9
names: Similarity
messages: Belongs to the Nudix hydrolase family.

384616:PISL RS01965
gene id: 384616:PISL_RS01965
uniprot id: A1RRI0
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

384616:PISL RS09810
gene id: 384616:PISL_RS09810
uniprot id: P81901
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Subunit
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
messages: Has a maximum absorption at about 282 nm.
messages: Monomer.
messages: The N-terminus is blocked.

384616:PISL RS04705
gene id: 384616:PISL_RS04705
uniprot id: A1RT06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

384616:PISL RS02495
gene id: 384616:PISL_RS02495
uniprot id: A1RRT2
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

384616:PISL RS07345
gene id: 384616:PISL_RS07345
uniprot id: A1RUF7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

384616:PISL RS03600
gene id: 384616:PISL_RS03600
uniprot id: A1RSE4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

384616:PISL RS03175
gene id: 384616:PISL_RS03175
uniprot id: A1RS61
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

384616:PISL RS03465
gene id: 384616:PISL_RS03465
uniprot id: A1RSB7
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

384616:PISL RS05775
gene id: 384616:PISL_RS05775
uniprot id: A1RTL2
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

384616:PISL RS08770
gene id: 384616:PISL_RS08770
uniprot id: A1RV79
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

384616:PISL RS08435
gene id: 384616:PISL_RS08435
uniprot id: A1RV12
names: Similarity
messages: Belongs to the peptidase M1 family.

384616:PISL RS08515
gene id: 384616:PISL_RS08515
uniprot id: A1RV28
names: Similarity
messages: Belongs to the UPF0201 family.

384616:PISL RS02270
gene id: 384616:PISL_RS02270
uniprot id: A1RRN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

384616:PISL RS05735
gene id: 384616:PISL_RS05735
uniprot id: A1RTK4
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

384616:PISL RS02575
gene id: 384616:PISL_RS02575
uniprot id: A1RRU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

384616:PISL RS06190
gene id: 384616:PISL_RS06190
uniprot id: A1RTU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

384616:PISL RS02530
gene id: 384616:PISL_RS02530
uniprot id: A1RRT9
names: Similarity
messages: Belongs to the glutaredoxin family.

384616:PISL RS01810
gene id: 384616:PISL_RS01810
uniprot id: A1RRE8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

384616:PISL RS02875
gene id: 384616:PISL_RS02875
uniprot id: A1RS05
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

384616:PISL RS04305
gene id: 384616:PISL_RS04305
uniprot id: A1RST0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteromeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

384616:PISL RS00995
gene id: 384616:PISL_RS00995
uniprot id: A1RQZ2
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

384616:PISL RS01790
gene id: 384616:PISL_RS01790
uniprot id: A1RRE4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

384616:PISL RS03890
gene id: 384616:PISL_RS03890
uniprot id: A1RSJ8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

384616:PISL RS06655
gene id: 384616:PISL_RS06655
uniprot id: A1RU26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

384616:PISL RS05525
gene id: 384616:PISL_RS05525
uniprot id: A1RTG3
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

384616:PISL RS02525
gene id: 384616:PISL_RS02525
uniprot id: A1RRT7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

384616:PISL RS00540
gene id: 384616:PISL_RS00540
uniprot id: A1RQQ3
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

384616:PISL RS01375
gene id: 384616:PISL_RS01375
uniprot id: A1RR61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

384616:PISL RS00160
gene id: 384616:PISL_RS00160
uniprot id: A1RQI1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

384616:PISL RS02630
gene id: 384616:PISL_RS02630
uniprot id: A1RRV7
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

384616:PISL RS08445
gene id: 384616:PISL_RS08445
uniprot id: A1RV14
names: Subcellular Location Annotation
messages: Nucleus

384616:PISL RS09475
gene id: 384616:PISL_RS09475
uniprot id: A1RVL2
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

384616:PISL RS04175
gene id: 384616:PISL_RS04175
uniprot id: A1RSQ5
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

384616:PISL RS00260
gene id: 384616:PISL_RS00260
uniprot id: A1RQK2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

384616:PISL RS08255
gene id: 384616:PISL_RS08255
uniprot id: A1RUX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

384616:PISL RS00870
gene id: 384616:PISL_RS00870
uniprot id: A1RQX0
names: Similarity
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

384616:PISL RS00505
gene id: 384616:PISL_RS00505
uniprot id: A1RQP7
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

384616:PISL RS01945
gene id: 384616:PISL_RS01945
uniprot id: A1RRH6
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

384616:PISL RS03000
gene id: 384616:PISL_RS03000
uniprot id: A1RS30
names: Similarity
messages: Belongs to the SUI1 family.

384616:PISL RS09580
gene id: 384616:PISL_RS09580
uniprot id: A1RVN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

384616:PISL RS09410
gene id: 384616:PISL_RS09410
uniprot id: A1RVK0
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.

384616:PISL RS04210
gene id: 384616:PISL_RS04210
uniprot id: A1RSR2
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

384616:PISL RS02935
gene id: 384616:PISL_RS02935
uniprot id: A1RS17
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

384616:PISL RS05405
gene id: 384616:PISL_RS05405
uniprot id: A1RTE0
names: Similarity
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.

384616:PISL RS07815
gene id: 384616:PISL_RS07815
uniprot id: A1RUP5
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS08885
gene id: 384616:PISL_RS08885
uniprot id: A1RVA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

384616:PISL RS01775
gene id: 384616:PISL_RS01775
uniprot id: A1RRE1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

384616:PISL RS06685
gene id: 384616:PISL_RS06685
uniprot id: A1RU32
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

384616:PISL RS01660
gene id: 384616:PISL_RS01660
uniprot id: A1RRB8
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS06230
gene id: 384616:PISL_RS06230
uniprot id: A1RTU8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

384616:PISL RS09575
gene id: 384616:PISL_RS09575
uniprot id: A1RVN0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

384616:PISL RS03095
gene id: 384616:PISL_RS03095
uniprot id: A1RS46
names: Function
messages: Catalyzes the synthesis of GMP from XMP.

384616:PISL RS04155
gene id: 384616:PISL_RS04155
uniprot id: A1RSQ1
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

384616:PISL RS06185
gene id: 384616:PISL_RS06185
uniprot id: A1RTT9
names: Similarity
messages: Belongs to the UPF0047 family.

384616:PISL RS05640
gene id: 384616:PISL_RS05640
uniprot id: A1RTI7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

384616:PISL RS08560
gene id: 384616:PISL_RS08560
uniprot id: A1RV37
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

384616:PISL RS03595
gene id: 384616:PISL_RS03595
uniprot id: A1RSE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

384616:PISL RS02985
gene id: 384616:PISL_RS02985
uniprot id: A1RS27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

384616:PISL RS06985
gene id: 384616:PISL_RS06985
uniprot id: A1RU91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

384616:PISL RS02545
gene id: 384616:PISL_RS02545
uniprot id: A1RRU2
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

384616:PISL RS09585
gene id: 384616:PISL_RS09585
uniprot id: A1RVN2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

384616:PISL RS05605
gene id: 384616:PISL_RS05605
uniprot id: A1RTI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

384616:PISL RS02060
gene id: 384616:PISL_RS02060
uniprot id: A1RRJ9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

384616:PISL RS03605
gene id: 384616:PISL_RS03605
uniprot id: A1RSE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

384616:PISL RS02605
gene id: 384616:PISL_RS02605
uniprot id: A1RRV2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

384616:PISL RS01595
gene id: 384616:PISL_RS01595
uniprot id: A1RRA5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Cytoplasm
messages: Homotetramer.

384616:PISL RS06130
gene id: 384616:PISL_RS06130
uniprot id: A1RTS9
names: Similarity
messages: Belongs to the thymidylate kinase family.

384616:PISL RS09380
gene id: 384616:PISL_RS09380
uniprot id: A1RVJ4
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

384616:PISL RS02835
gene id: 384616:PISL_RS02835
uniprot id: A1RRZ8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.

384616:PISL RS08325
gene id: 384616:PISL_RS08325
uniprot id: A1RUZ1
names: Similarity
messages: Belongs to the carbamate kinase family.

384616:PISL RS04615
gene id: 384616:PISL_RS04615
uniprot id: A1RSZ0
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS08505
gene id: 384616:PISL_RS08505
uniprot id: A1RV26
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

384616:PISL RS10345
gene id: 384616:PISL_RS10345
uniprot id: A1RW25
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

384616:PISL RS06325
gene id: 384616:PISL_RS06325
uniprot id: A1RTW4
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

384616:PISL RS04790
gene id: 384616:PISL_RS04790
uniprot id: A1RT23
names: Similarity
messages: Belongs to the BtpA family.

384616:PISL RS02815
gene id: 384616:PISL_RS02815
uniprot id: A1RRZ4
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

384616:PISL RS04960
gene id: 384616:PISL_RS04960
uniprot id: A1RT54
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Binds two Mg(2+) per subunit.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome.

384616:PISL RS05635
gene id: 384616:PISL_RS05635
uniprot id: A1RTI6
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

384616:PISL RS07960
gene id: 384616:PISL_RS07960
uniprot id: A1RUS1
names: Similarity
messages: Belongs to the heat shock protein 90 family.

384616:PISL RS08600
gene id: 384616:PISL_RS08600
uniprot id: A1RV45
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

384616:PISL RS06035
gene id: 384616:PISL_RS06035
uniprot id: A1RTR0
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

384616:PISL RS01600
gene id: 384616:PISL_RS01600
uniprot id: A1RRA6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.

384616:PISL RS06200
gene id: 384616:PISL_RS06200
uniprot id: A1RTU2
names: Similarity
messages: Belongs to the isopentenyl phosphate kinase family.

384616:PISL RS06945
gene id: 384616:PISL_RS06945
uniprot id: A1RU83
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS04290
gene id: 384616:PISL_RS04290
uniprot id: A1RSS7
names: Function
messages: Probably involved in the biogenesis of the ribosome.

384616:PISL RS06405
gene id: 384616:PISL_RS06405
uniprot id: A1RTX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

384616:PISL RS09750
gene id: 384616:PISL_RS09750
uniprot id: A1RVQ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.

384616:PISL RS03295
gene id: 384616:PISL_RS03295
uniprot id: A1RS85
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

384616:PISL RS03395
gene id: 384616:PISL_RS03395
uniprot id: A1RSA3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

384616:PISL RS08675
gene id: 384616:PISL_RS08675
uniprot id: A1RV60
names: Similarity
messages: Belongs to the malic enzymes family.

384616:PISL RS02260
gene id: 384616:PISL_RS02260
uniprot id: A1RRN7
names: Similarity
messages: Belongs to the PDCD5 family.

384616:PISL RS03120
gene id: 384616:PISL_RS03120
uniprot id: A1RS50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

384616:PISL RS09250
gene id: 384616:PISL_RS09250
uniprot id: A1RVG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

384616:PISL RS04280
gene id: 384616:PISL_RS04280
uniprot id: A1RSS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

384616:PISL RS02230
gene id: 384616:PISL_RS02230
uniprot id: A1RRN1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

384616:PISL RS08540
gene id: 384616:PISL_RS08540
uniprot id: A1RV33
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

384616:PISL RS08750
gene id: 384616:PISL_RS08750
uniprot id: A1RV75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

384616:PISL RS05630
gene id: 384616:PISL_RS05630
uniprot id: A1RTI5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

384616:PISL RS04190
gene id: 384616:PISL_RS04190
uniprot id: A1RSQ8
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

384616:PISL RS03020
gene id: 384616:PISL_RS03020
uniprot id: A1RS33
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

384616:PISL RS05770
gene id: 384616:PISL_RS05770
uniprot id: A1RTL1
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS05060
gene id: 384616:PISL_RS05060
uniprot id: A1RT74
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

384616:PISL RS02425
gene id: 384616:PISL_RS02425
uniprot id: A1RRR9
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS02050
gene id: 384616:PISL_RS02050
uniprot id: A1RRJ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

384616:PISL RS00920
gene id: 384616:PISL_RS00920
uniprot id: A1RQX8
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

384616:PISL RS09115
gene id: 384616:PISL_RS09115
uniprot id: A1RVE0
names: Similarity
messages: Belongs to the EPSP synthase family.

384616:PISL RS08615
gene id: 384616:PISL_RS08615
uniprot id: A1RV48
names: Similarity
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.

384616:PISL RS00600
gene id: 384616:PISL_RS00600
uniprot id: A1RQR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

384616:PISL RS09210
gene id: 384616:PISL_RS09210
uniprot id: A1RVG1
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

384616:PISL RS04025
gene id: 384616:PISL_RS04025
uniprot id: A1RSM4
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

384616:PISL RS03800
gene id: 384616:PISL_RS03800
uniprot id: A1RSI3
names: Similarity
messages: Belongs to the AOR/FOR family.

384616:PISL RS04645
gene id: 384616:PISL_RS04645
uniprot id: A1RSZ6
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS06580
gene id: 384616:PISL_RS06580
uniprot id: A1RU12
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.

384616:PISL RS00925
gene id: 384616:PISL_RS00925
uniprot id: A1RQX9
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

384616:PISL RS07460
gene id: 384616:PISL_RS07460
uniprot id: A1RUH9
names: Similarity
messages: Belongs to the P(II) protein family.

384616:PISL RS06615
gene id: 384616:PISL_RS06615
uniprot id: A1RU18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

384616:PISL RS01405
gene id: 384616:PISL_RS01405
uniprot id: A1RR67
names: Caution
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

384616:PISL RS05220
gene id: 384616:PISL_RS05220
uniprot id: A1RTA4
names: Subcellular Location Annotation
messages: Membrane

384616:PISL RS01570
gene id: 384616:PISL_RS01570
uniprot id: A1RRA0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

384616:PISL RS00220
gene id: 384616:PISL_RS00220
uniprot id: A1RQJ4
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

384616:PISL RS06860
gene id: 384616:PISL_RS06860
uniprot id: A1RU67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

384616:PISL RS03285
gene id: 384616:PISL_RS03285
uniprot id: A1RS83
names: Similarity
messages: Belongs to the peptidase M20A family.

384616:PISL RS04160
gene id: 384616:PISL_RS04160
uniprot id: A1RSQ2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

384616:PISL RS04660
gene id: 384616:PISL_RS04660
uniprot id: A1RSZ8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

384616:PISL RS06795
gene id: 384616:PISL_RS06795
uniprot id: A1RU54
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnA subfamily.
messages: Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

384616:PISL RS04980
gene id: 384616:PISL_RS04980
uniprot id: A1RT57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

384616:PISL RS03160
gene id: 384616:PISL_RS03160
uniprot id: A1RS58
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate. Exhibits higher specific activity for oxaloacetate reduction than for malate oxidation in vitro. Has a strong preference for NAD. Can use NADPH for oxaloacetate reduction, but activity decreases more than 90%. No activity detected with NADP(+) and malate.
messages: Homotetramer.

384616:PISL RS03935
gene id: 384616:PISL_RS03935
uniprot id: A1RSK7
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

384616:PISL RS02265
gene id: 384616:PISL_RS02265
uniprot id: A1RRN8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

384616:PISL RS08730
gene id: 384616:PISL_RS08730
uniprot id: A1RV71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
messages: Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.
messages: Homotetramer; dimer of dimers.
messages: Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate.

384616:PISL RS02360
gene id: 384616:PISL_RS02360
uniprot id: A1RRQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

384616:PISL RS04415
gene id: 384616:PISL_RS04415
uniprot id: A1RSV1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

384616:PISL RS06260
gene id: 384616:PISL_RS06260
uniprot id: A1RTV4
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

384616:PISL RS02030
gene id: 384616:PISL_RS02030
uniprot id: A1RRJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

384616:PISL RS10275
gene id: 384616:PISL_RS10275
uniprot id: A1RW10
names: Cofactor
messages: Binds 4 [4Fe-4S] clusters per subunit.

384616:PISL RS01345
gene id: 384616:PISL_RS01345
uniprot id: A1RR57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.