37040:LHFPL2
gene id: 37040:LHFPL2
uniprot id: A0A093F1H1
names: Subcellular Location Annotation
messages: Membrane

37040:TMEM184B
gene id: 37040:TMEM184B
uniprot id: A0A093FIH9
names: Subcellular Location Annotation
messages: Membrane

37040:CPB1
gene id: 37040:CPB1
uniprot id: A0A093FC13
names: Similarity
messages: Belongs to the peptidase M14 family.

37040:NRXN3
gene id: 37040:NRXN3
uniprot id: A0A093EUJ4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

37040:ADIPOR2
gene id: 37040:ADIPOR2
uniprot id: A0A093F381
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

37040:RAD52
gene id: 37040:RAD52
uniprot id: A0A093FIV1
names: Similarity
messages: Belongs to the RAD52 family.

37040:LEAP2
gene id: 37040:LEAP2
uniprot id: A0A093FRT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEAP2 family.
messages: Has an antimicrobial activity.
messages: Secreted

37040:MAFK
gene id: 37040:MAFK
uniprot id: A0A093ENL0
names: Similarity
messages: Belongs to the bZIP family. Maf subfamily.

37040:AP1S2
gene id: 37040:AP1S2
uniprot id: A0A093F0C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: clathrin-coated pit

37040:KCNH7
gene id: 37040:KCNH7
uniprot id: A0A093EW71
names: Subcellular Location Annotation
messages: Membrane

37040:TMEM255B
gene id: 37040:TMEM255B
uniprot id: A0A093F9G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM255 family.
messages: Membrane

37040:ASRGL1
gene id: 37040:ASRGL1
uniprot id: A0A093F726
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

37040:RBM22
gene id: 37040:RBM22
uniprot id: A0A093FLR1
names: Similarity
messages: Belongs to the SLT11 family.

37040:RGS9BP
gene id: 37040:RGS9BP
uniprot id: A0A093HZR0
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

37040:DMGDH
gene id: 37040:DMGDH
uniprot id: A0A093F5H1
names: Similarity
messages: Belongs to the GcvT family.

37040:GJA3
gene id: 37040:GJA3
uniprot id: A0A093HXN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

37040:B3GNT2
gene id: 37040:B3GNT2
uniprot id: A0A093FS67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

37040:TMEM121
gene id: 37040:TMEM121
uniprot id: A0A093FF72
names: Similarity
messages: Belongs to the TMEM121 family.

37040:FGFBP2
gene id: 37040:FGFBP2
uniprot id: A0A093F231
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

37040:POMK
gene id: 37040:POMK
uniprot id: A0A093HD53
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif.

37040:PLRG1
gene id: 37040:PLRG1
uniprot id: A0A093EZ13
names: Similarity
messages: Belongs to the WD repeat PRL1/PRL2 family.

37040:NIPAL3
gene id: 37040:NIPAL3
uniprot id: A0A093FJP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

37040:BCR
gene id: 37040:BCR
uniprot id: A0A093F6H9
names: Subcellular Location Annotation
messages: Synapse
messages: axon
messages: dendritic spine

37040:SRP54
gene id: 37040:SRP54
uniprot id: A0A093F4L6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Nucleus speckle
messages: The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.
messages: The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

37040:PCMTD1
gene id: 37040:PCMTD1
uniprot id: A0A093ETH3
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

37040:MAPKAPK3
gene id: 37040:MAPKAPK3
uniprot id: A0A093F6J8
names: Similarity
messages: Belongs to the protein kinase superfamily.

37040:PRKAB2
gene id: 37040:PRKAB2
uniprot id: A0A093EQP0
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

37040:ARPC2
gene id: 37040:ARPC2
uniprot id: A0A093HID6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Cell projection
messages: Component of the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

37040:CRYAB
gene id: 37040:CRYAB
uniprot id: A0A093F4P3
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

37040:PAQR8
gene id: 37040:PAQR8
uniprot id: A0A093HCC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

37040:SLC39A3
gene id: 37040:SLC39A3
uniprot id: A0A093FE36
names: Subcellular Location Annotation
messages: Membrane

37040:TRIAP1
gene id: 37040:TRIAP1
uniprot id: A0A093H1I9
names: Similarity
messages: Belongs to the TRIAP1/MDM35 family.

37040:SLC7A1
gene id: 37040:SLC7A1
uniprot id: A0A093FC54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

37040:BMP5
gene id: 37040:BMP5
uniprot id: A0A093F6Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Secreted

37040:TMEM177
gene id: 37040:TMEM177
uniprot id: A0A093F3D3
names: Function
names: Similarity
messages: Belongs to the TMEM177 family.
messages: Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein.

37040:MYBL1
gene id: 37040:MYBL1
uniprot id: A0A093F5C7
names: Subcellular Location Annotation
messages: Nucleus

37040:MDM4
gene id: 37040:MDM4
uniprot id: A0A093EYH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM2/MDM4 family.
messages: Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.
messages: Nucleus

37040:DRD1
gene id: 37040:DRD1
uniprot id: A0A093FL90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

37040:NUP50
gene id: 37040:NUP50
uniprot id: A0A093F667
names: Subcellular Location Annotation
messages: nuclear pore complex

37040:LOC104257729
gene id: 37040:LOC104257729
uniprot id: A0A093GXL1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

37040:LOC104260587
gene id: 37040:LOC104260587
uniprot id: A0A093HRP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dienelactone hydrolase family.
messages: cytosol

37040:PRICKLE1
gene id: 37040:PRICKLE1
uniprot id: A0A093FP68
names: Similarity
messages: Belongs to the prickle / espinas / testin family.

37040:CLRN3
gene id: 37040:CLRN3
uniprot id: A0A093HF95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

37040:MET
gene id: 37040:MET
uniprot id: A0A093FVZ7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

37040:SLC6A1
gene id: 37040:SLC6A1
uniprot id: A0A093EYH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

37040:NDUFB4
gene id: 37040:NDUFB4
uniprot id: A0A093FAI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

37040:CELF1
gene id: 37040:CELF1
uniprot id: A0A093FMV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

37040:LRRC8D
gene id: 37040:LRRC8D
uniprot id: A0A093FBP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

37040:CPLX4
gene id: 37040:CPLX4
uniprot id: A0A093FTM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

37040:PALS1
gene id: 37040:PALS1
uniprot id: A0A093FHL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: tight junction

37040:GJA1
gene id: 37040:GJA1
uniprot id: A0A093HH33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

37040:CACNB2
gene id: 37040:CACNB2
uniprot id: A0A093FJ87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: sarcolemma

37040:SLC5A7
gene id: 37040:SLC5A7
uniprot id: A0A093EZC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

37040:GTF2H2
gene id: 37040:GTF2H2
uniprot id: A0A093EZP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTF2H2 family.
messages: Nucleus

37040:CRYAA
gene id: 37040:CRYAA
uniprot id: A0A093HTQ0
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

37040:MACIR
gene id: 37040:MACIR
uniprot id: A0A093F012
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UNC119-binding protein family.
messages: Cytoplasm
messages: cilium

37040:AP3S1
gene id: 37040:AP3S1
uniprot id: A0A093F7I3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

37040:NDUFS1
gene id: 37040:NDUFS1
uniprot id: A0A093HIM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I 75 kDa subunit family.
messages: Mitochondrion inner membrane

37040:GDAP2
gene id: 37040:GDAP2
uniprot id: A0A093F523
names: Similarity
messages: Belongs to the GDAP2 family.

37040:MNAT1
gene id: 37040:MNAT1
uniprot id: A0A093FYD3
names: Subcellular Location Annotation
messages: Nucleus

37040:EIF2S1
gene id: 37040:EIF2S1
uniprot id: A0A093GYJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2-alpha family.
messages: Stress granule

37040:EMC2
gene id: 37040:EMC2
uniprot id: A0A093HWU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.

37040:PLPPR5
gene id: 37040:PLPPR5
uniprot id: A0A093EX59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

37040:LOC104261530
gene id: 37040:LOC104261530
uniprot id: A0A093FVF2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes.
messages: Homodimer; disulfide-linked.
messages: Membrane

37040:YES1
gene id: 37040:YES1
uniprot id: A0A093FM03
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

37040:BET1
gene id: 37040:BET1
uniprot id: A0A093FNQ3
names: Subcellular Location Annotation
messages: Membrane

37040:VPS26C
gene id: 37040:VPS26C
uniprot id: A0A093FY92
names: Similarity
messages: Belongs to the VPS26 family.

37040:PTX3
gene id: 37040:PTX3
uniprot id: A0A093FI79
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

37040:PSMB1
gene id: 37040:PSMB1
uniprot id: A0A093EWM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

37040:UBLCP1
gene id: 37040:UBLCP1
uniprot id: A0A093F1J0
names: Subcellular Location Annotation
messages: Nucleus

37040:PPP2R5E
gene id: 37040:PPP2R5E
uniprot id: A0A093F7J6
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.

37040:LOC104254225
gene id: 37040:LOC104254225
uniprot id: A0A093EYR2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

37040:LOC104261611
gene id: 37040:LOC104261611
uniprot id: A0A093HV46
names: Similarity
messages: Belongs to the serpin family.

37040:KCNJ2
gene id: 37040:KCNJ2
uniprot id: A0A093G247
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
messages: Membrane

37040:ATP10B
gene id: 37040:ATP10B
uniprot id: A0A093FVM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

37040:C8B
gene id: 37040:C8B
uniprot id: A0A093ETW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

37040:GEM
gene id: 37040:GEM
uniprot id: A0A093EXA8
names: Similarity
messages: Belongs to the small GTPase superfamily. RGK family.

37040:RBM48
gene id: 37040:RBM48
uniprot id: A0A093H9U8
names: Function
names: Similarity
messages: As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.
messages: Belongs to the RBM48 family.

37040:SCG2
gene id: 37040:SCG2
uniprot id: A0A093EQU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromogranin/secretogranin protein family.
messages: Secreted

37040:FGF6
gene id: 37040:FGF6
uniprot id: A0A093FF50
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

37040:ODAD4
gene id: 37040:ODAD4
uniprot id: A0A093FEH2
names: Subcellular Location Annotation
messages: cilium axoneme

37040:DMBX1
gene id: 37040:DMBX1
uniprot id: A0A093I1K8
names: Subcellular Location Annotation
messages: Nucleus

37040:BDNF
gene id: 37040:BDNF
uniprot id: A0A093F676
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGF-beta family.
messages: Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it.
messages: Secreted

37040:SEC23A
gene id: 37040:SEC23A
uniprot id: A0A093ETA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

37040:HTR1E
gene id: 37040:HTR1E
uniprot id: A0A093FCY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

37040:CLDN14
gene id: 37040:CLDN14
uniprot id: A0A093GXW2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

37040:ISCA1
gene id: 37040:ISCA1
uniprot id: A0A093FCV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

37040:BDH1
gene id: 37040:BDH1
uniprot id: A0A093GYT5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

37040:PLIN2
gene id: 37040:PLIN2
uniprot id: A0A093FH14
names: Similarity
messages: Belongs to the perilipin family.

37040:TMEM45A
gene id: 37040:TMEM45A
uniprot id: A0A093FUI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

37040:GINS1
gene id: 37040:GINS1
uniprot id: A0A093EZJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.

37040:RPL6
gene id: 37040:RPL6
uniprot id: A0A093FNX9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

37040:LOC104260632
gene id: 37040:LOC104260632
uniprot id: A0A093FSH3
names: Similarity
messages: Belongs to the cytochrome P450 family.

37040:PTER
gene id: 37040:PTER
uniprot id: A0A093F1P3
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
messages: Binds 2 divalent metal cations per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

37040:HACL1
gene id: 37040:HACL1
uniprot id: A0A093HFE7
names: Similarity
messages: Belongs to the TPP enzyme family.

37040:LOC104253435
gene id: 37040:LOC104253435
uniprot id: A0A093F5Z2
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

37040:NR3C1
gene id: 37040:NR3C1
uniprot id: A0A093ETX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

37040:GPX8
gene id: 37040:GPX8
uniprot id: A0A093FJC3
names: Similarity
messages: Belongs to the glutathione peroxidase family.

37040:SNRPD3
gene id: 37040:SNRPD3
uniprot id: A0A093FV91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: cytosol

37040:DHDDS
gene id: 37040:DHDDS
uniprot id: A0A093FCX7
names: Similarity
messages: Belongs to the UPP synthase family.

37040:CRHBP
gene id: 37040:CRHBP
uniprot id: A0A093FEP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRF-binding protein family.
messages: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
messages: Secreted

37040:FRRS1
gene id: 37040:FRRS1
uniprot id: A0A093HD65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRRS1 family.
messages: Membrane

37040:LOC104258534
gene id: 37040:LOC104258534
uniprot id: A0A093HJI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

37040:WASF3
gene id: 37040:WASF3
uniprot id: A0A093G2C4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

37040:GOLT1A
gene id: 37040:GOLT1A
uniprot id: A0A093EV20
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
messages: Membrane

37040:ATP6V0A4
gene id: 37040:ATP6V0A4
uniprot id: A0A093HJG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

37040:TPRKB
gene id: 37040:TPRKB
uniprot id: A0A093ENR8
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

37040:SYT1
gene id: 37040:SYT1
uniprot id: A0A093FGJ4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: synaptic vesicle membrane

37040:S100B
gene id: 37040:S100B
uniprot id: A0A093HSU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the S-100 family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

37040:HMGB2
gene id: 37040:HMGB2
uniprot id: A0A093F7K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

37040:NSG1
gene id: 37040:NSG1
uniprot id: A0A093FPS4
names: Similarity
messages: Belongs to the NSG family.

37040:GDF9
gene id: 37040:GDF9
uniprot id: A0A093FC80
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.
messages: Secreted

37040:LOC104259124
gene id: 37040:LOC104259124
uniprot id: A0A093FM66
names: Similarity
messages: Belongs to the actin family.

37040:SPECC1L
gene id: 37040:SPECC1L
uniprot id: A0A093FKK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytospin-A family.
messages: Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.
messages: May interact with both microtubules and actin cytoskeleton.
messages: cytoskeleton
messages: gap junction
messages: spindle

37040:UNG
gene id: 37040:UNG
uniprot id: A0A093F9J9
names: Function
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

37040:PLPPR4
gene id: 37040:PLPPR4
uniprot id: A0A093FLH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

37040:HTR2A
gene id: 37040:HTR2A
uniprot id: A0A093HFP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin).
messages: Membrane
messages: Presynapse
messages: Synapse
messages: Vesicle
messages: axon
messages: caveola
messages: dendrite

37040:CENPV
gene id: 37040:CENPV
uniprot id: A0A093FHW7
names: Similarity
messages: Belongs to the Gfa family.

37040:CLDN18
gene id: 37040:CLDN18
uniprot id: A0A093F7H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: tight junction

37040:PHKG1
gene id: 37040:PHKG1
uniprot id: A0A093H9M0
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

37040:ANO10
gene id: 37040:ANO10
uniprot id: A0A093FWU0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

37040:FKTN
gene id: 37040:FKTN
uniprot id: A0A093FEM5
names: Similarity
messages: Belongs to the LicD transferase family.

37040:RMI1
gene id: 37040:RMI1
uniprot id: A0A093H4L1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RMI1 family.
messages: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
messages: Nucleus

37040:EGF
gene id: 37040:EGF
uniprot id: A0A093H981
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

37040:LOC104264535
gene id: 37040:LOC104264535
uniprot id: A0A093F3T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

37040:ELAVL1
gene id: 37040:ELAVL1
uniprot id: A0A093FP30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM elav family.
messages: Cytoplasm

37040:LDB2
gene id: 37040:LDB2
uniprot id: A0A093ETA7
names: Similarity
messages: Belongs to the LDB family.

37040:DYNC1I2
gene id: 37040:DYNC1I2
uniprot id: A0A093FD36
names: Similarity
messages: Belongs to the dynein intermediate chain family.

37040:MYMK
gene id: 37040:MYMK
uniprot id: A0A093EV36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM8 family.
messages: Cell membrane
messages: Membrane

37040:VPS36
gene id: 37040:VPS36
uniprot id: A0A093F0I9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS36 family.
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).
messages: Cytoplasm
messages: Endosome

37040:INHBA
gene id: 37040:INHBA
uniprot id: A0A093HZE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

37040:LOC104258364
gene id: 37040:LOC104258364
uniprot id: A0A093FD51
names: Similarity
messages: Belongs to the fructosamine kinase family.

37040:RNF20
gene id: 37040:RNF20
uniprot id: A0A093HCL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRE1 family.
messages: Nucleus

37040:TRPC5
gene id: 37040:TRPC5
uniprot id: A0A093EXM0
names: Subcellular Location Annotation
messages: Membrane

37040:TCEANC
gene id: 37040:TCEANC
uniprot id: A0A093FRB6
names: Subcellular Location Annotation
messages: Nucleus

37040:RFLNA
gene id: 37040:RFLNA
uniprot id: A0A093F996
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Refilin family.
messages: Interacts with FLNA and FLNB.
messages: cytoskeleton

37040:GPR12
gene id: 37040:GPR12
uniprot id: A0A093F1M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

37040:HSPD1
gene id: 37040:HSPD1
uniprot id: A0A093HVQ0
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

37040:POLR3H
gene id: 37040:POLR3H
uniprot id: A0A093FEV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

37040:MAT2B
gene id: 37040:MAT2B
uniprot id: A0A093F7Z1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.
messages: Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.
messages: Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.

37040:PLCB4
gene id: 37040:PLCB4
uniprot id: A0A093F6Z1
names: Cofactor
names: Function
messages: Binds 1 Ca(2+) ion per subunit.
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

37040:ANXA7
gene id: 37040:ANXA7
uniprot id: A0A093F9D3
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

37040:MINAR1
gene id: 37040:MINAR1
uniprot id: A0A093HHV1
names: Similarity
messages: Belongs to the MINAR family.

37040:ABCA5
gene id: 37040:ABCA5
uniprot id: A0A093H4J6
names: Subcellular Location Annotation
messages: Membrane

37040:SYNDIG1
gene id: 37040:SYNDIG1
uniprot id: A0A093FP45
names: Similarity
messages: Belongs to the CD225/Dispanin family.

37040:HMGB3
gene id: 37040:HMGB3
uniprot id: A0A093ESA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

37040:PTP4A1
gene id: 37040:PTP4A1
uniprot id: A0A093FSL3
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

37040:SLC5A11
gene id: 37040:SLC5A11
uniprot id: A0A093HFR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

37040:PLN
gene id: 37040:PLN
uniprot id: A0A093FRA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholamban family.
messages: Endoplasmic reticulum membrane
messages: Homopentamer.
messages: Membrane
messages: Mitochondrion membrane
messages: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
messages: Sarcoplasmic reticulum membrane

37040:DNTT
gene id: 37040:DNTT
uniprot id: A0A093EPJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Nucleus
messages: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.

37040:TSSC4
gene id: 37040:TSSC4
uniprot id: A0A093FKQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TSSC4 family.
messages: Cytoplasm
messages: Nucleus

37040:LOC104257472
gene id: 37040:LOC104257472
uniprot id: A0A093GXF7
names: Subunit
messages: Monomer.

37040:C15H19orf12
gene id: 37040:C15H19orf12
uniprot id: A0A093F9C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the C19orf12 family.
messages: Mitochondrion membrane

37040:SLC16A9
gene id: 37040:SLC16A9
uniprot id: A0A093FH17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Cell membrane
messages: Membrane

37040:PCYT1A
gene id: 37040:PCYT1A
uniprot id: A0A093FHK3
names: Function
names: Similarity
messages: Belongs to the cytidylyltransferase family.
messages: Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.

37040:CLTRN
gene id: 37040:CLTRN
uniprot id: A0A093HVG6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

37040:LOC104254245
gene id: 37040:LOC104254245
uniprot id: A0A093F8I2
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

37040:TSPAN18
gene id: 37040:TSPAN18
uniprot id: A0A093EWW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

37040:FAM20B
gene id: 37040:FAM20B
uniprot id: A0A093FSE5
names: Similarity
messages: Belongs to the FAM20 family.

37040:RPL36
gene id: 37040:RPL36
uniprot id: A0A093HZB1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

37040:PEX5L
gene id: 37040:PEX5L
uniprot id: A0A093HDJ0
names: Similarity
messages: Belongs to the peroxisomal targeting signal receptor family.

37040:LOC104264553
gene id: 37040:LOC104264553
uniprot id: A0A093EXA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

37040:SIN3A
gene id: 37040:SIN3A
uniprot id: A0A093FHE6
names: Subcellular Location Annotation
messages: Nucleus

37040:LOC104261894
gene id: 37040:LOC104261894
uniprot id: A0A093FWP4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

37040:TPT1
gene id: 37040:TPT1
uniprot id: A0A093HAH2
names: Similarity
messages: Belongs to the TCTP family.

37040:CLCN3
gene id: 37040:CLCN3
uniprot id: A0A093FQA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane

37040:SPDL1
gene id: 37040:SPDL1
uniprot id: A0A093FP28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Spindly family.
messages: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex.
messages: kinetochore

37040:CALHM1
gene id: 37040:CALHM1
uniprot id: A0A093F6N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

37040:LOC104254783
gene id: 37040:LOC104254783
uniprot id: A0A093H919
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.
messages: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.

37040:PCBD2
gene id: 37040:PCBD2
uniprot id: A0A093FUX9
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

37040:DPT
gene id: 37040:DPT
uniprot id: A0A093G0T4
names: Similarity
messages: Belongs to the dermatopontin family.

37040:TFB1M
gene id: 37040:TFB1M
uniprot id: A0A093GZY1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

37040:LOC104261609
gene id: 37040:LOC104261609
uniprot id: A0A093FKZ2
names: Similarity
messages: Belongs to the serpin family.

37040:ABCC5
gene id: 37040:ABCC5
uniprot id: A0A093F623
names: Subcellular Location Annotation
messages: Membrane

37040:ANKRD34B
gene id: 37040:ANKRD34B
uniprot id: A0A093FR86
names: Similarity
messages: Belongs to the ANKRD34 family.

37040:DDC
gene id: 37040:DDC
uniprot id: A0A093G0D5
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

37040:TSPAN5
gene id: 37040:TSPAN5
uniprot id: A0A093FJL5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

37040:HIBCH
gene id: 37040:HIBCH
uniprot id: A0A093FAQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.
messages: Mitochondrion

37040:TADA2A
gene id: 37040:TADA2A
uniprot id: A0A093FL75
names: Subcellular Location Annotation
messages: Nucleus

37040:MAPK6
gene id: 37040:MAPK6
uniprot id: A0A093G0Y8
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

37040:SH3BP4
gene id: 37040:SH3BP4
uniprot id: A0A093FD45
names: Subcellular Location Annotation
messages: Nucleus
messages: Vesicle
messages: clathrin-coated pit
messages: clathrin-coated vesicle

37040:SGMS2
gene id: 37040:SGMS2
uniprot id: A0A093F3S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

37040:AURKAIP1
gene id: 37040:AURKAIP1
uniprot id: A0A093HMC1
names: Similarity
messages: Belongs to the mitochondrion-specific ribosomal protein mS38 family.

37040:ANXA1
gene id: 37040:ANXA1
uniprot id: A0A093FXX8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Cytoplasm
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
messages: cilium

37040:GRIN3A
gene id: 37040:GRIN3A
uniprot id: A0A093FLR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

37040:LOC104264009
gene id: 37040:LOC104264009
uniprot id: A0A093H0I5
names: Similarity
messages: Belongs to the serpin family.

37040:SCAMP1
gene id: 37040:SCAMP1
uniprot id: A0A093FDN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

37040:ACTA2
gene id: 37040:ACTA2
uniprot id: A0A093F675
names: Similarity
messages: Belongs to the actin family.

37040:ASF1A
gene id: 37040:ASF1A
uniprot id: A0A093FDB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

37040:STAMBP
gene id: 37040:STAMBP
uniprot id: A0A093FQX5
names: Similarity
messages: Belongs to the peptidase M67C family.

37040:BIRC2
gene id: 37040:BIRC2
uniprot id: A0A093FR26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IAP family.
messages: Cytoplasm
messages: Nucleus

37040:HYCC2
gene id: 37040:HYCC2
uniprot id: A0A093H0T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Hyccin family.
messages: Cell membrane
messages: Membrane
messages: cytosol

37040:TNMD
gene id: 37040:TNMD
uniprot id: A0A093HX85
names: Similarity
messages: Belongs to the chondromodulin-1 family.

37040:MSH2
gene id: 37040:MSH2
uniprot id: A0A093FMG3
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.

37040:WASHC1
gene id: 37040:WASHC1
uniprot id: A0A093HHA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WASH1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Recycling endosome membrane

37040:ADD3
gene id: 37040:ADD3
uniprot id: A0A093EZ74
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

37040:LIG4
gene id: 37040:LIG4
uniprot id: A0A093F062
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

37040:MMP23B
gene id: 37040:MMP23B
uniprot id: A0A093F562
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

37040:PDE6B
gene id: 37040:PDE6B
uniprot id: A0A093FPJ7
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

37040:SYNDIG1L
gene id: 37040:SYNDIG1L
uniprot id: A0A093F0T9
names: Similarity
messages: Belongs to the CD225/Dispanin family.

37040:BUD23
gene id: 37040:BUD23
uniprot id: A0A093H7G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.
messages: Cytoplasm
messages: Nucleus

37040:SLCO3A1
gene id: 37040:SLCO3A1
uniprot id: A0A093F0D4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

37040:MAT1A
gene id: 37040:MAT1A
uniprot id: A0A093ETD7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

37040:SPSB1
gene id: 37040:SPSB1
uniprot id: A0A093EWL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPSB family.
messages: Cytoplasm

37040:ARK2N
gene id: 37040:ARK2N
uniprot id: A0A093HF85
names: Subcellular Location Annotation
messages: Nucleus

37040:CSTF1
gene id: 37040:CSTF1
uniprot id: A0A093FXT7
names: Subcellular Location Annotation
messages: Nucleus

37040:PTH
gene id: 37040:PTH
uniprot id: A0A093GYA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parathyroid hormone family.
messages: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion.
messages: Secreted

37040:HOPX
gene id: 37040:HOPX
uniprot id: A0A093FNF3
names: Subcellular Location Annotation
messages: Nucleus

37040:CEBPG
gene id: 37040:CEBPG
uniprot id: A0A093FZH8
names: Similarity
messages: Belongs to the bZIP family. C/EBP subfamily.

37040:LOC104263787
gene id: 37040:LOC104263787
uniprot id: A0A093ERJ9
names: Similarity
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

37040:A1CF
gene id: 37040:A1CF
uniprot id: A0A093FK65
names: Subcellular Location Annotation
messages: Cytoplasm

37040:PRPF4B
gene id: 37040:PRPF4B
uniprot id: A0A093F1J3
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.
messages: Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.

37040:NSG2
gene id: 37040:NSG2
uniprot id: A0A093FYS7
names: Similarity
messages: Belongs to the NSG family.

37040:MIS12
gene id: 37040:MIS12
uniprot id: A0A093FG53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mis12 family.
messages: kinetochore

37040:MAP2
gene id: 37040:MAP2
uniprot id: A0A093EXG7
names: Subcellular Location Annotation
messages: cytoskeleton

37040:ACO2
gene id: 37040:ACO2
uniprot id: A0A093HDP5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
messages: Mitochondrion

37040:CALHM5
gene id: 37040:CALHM5
uniprot id: A0A093FJY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

37040:TUBE1
gene id: 37040:TUBE1
uniprot id: A0A093FUH2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: cytoskeleton

37040:CSNK2A2
gene id: 37040:CSNK2A2
uniprot id: A0A093FJ79
names: Similarity
messages: Belongs to the protein kinase superfamily.

37040:LRRC8C
gene id: 37040:LRRC8C
uniprot id: A0A093FEB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

37040:DPY19L3
gene id: 37040:DPY19L3
uniprot id: A0A093FDZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

37040:MTURN
gene id: 37040:MTURN
uniprot id: A0A093FBL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTURN family.
messages: Cytoplasm

37040:ZNF706
gene id: 37040:ZNF706
uniprot id: A0A093FZ20
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

37040:LPGAT1
gene id: 37040:LPGAT1
uniprot id: A0A093FTP8
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

37040:OGN
gene id: 37040:OGN
uniprot id: A0A093FUX0
names: Similarity
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

37040:NCK2
gene id: 37040:NCK2
uniprot id: A0A093F8M0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

37040:RUVBL1
gene id: 37040:RUVBL1
uniprot id: A0A093F0A3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

37040:SLC1A3
gene id: 37040:SLC1A3
uniprot id: A0A093FLX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

37040:EEIG1
gene id: 37040:EEIG1
uniprot id: A0A093FEQ5
names: Similarity
messages: Belongs to the EEIG family.

37040:LPAR3
gene id: 37040:LPAR3
uniprot id: A0A093F684
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

37040:SLC16A3
gene id: 37040:SLC16A3
uniprot id: A0A093F4W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

37040:LOC104264191
gene id: 37040:LOC104264191
uniprot id: A0A093ESW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CITED family.
messages: Nucleus

37040:TNFSF13B
gene id: 37040:TNFSF13B
uniprot id: A0A093ERC9
names: Similarity
messages: Belongs to the tumor necrosis factor family.

37040:POLR2J
gene id: 37040:POLR2J
uniprot id: A0A093FIR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Nucleus

37040:RAB9B
gene id: 37040:RAB9B
uniprot id: A0A093H7C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: phagosome membrane

37040:IMMP1L
gene id: 37040:IMMP1L
uniprot id: A0A093F5Q8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26 family.
messages: Heterodimer of 2 subunits, IMMPL1 and IMMPL2.
messages: Mitochondrion inner membrane

37040:BCL2A1
gene id: 37040:BCL2A1
uniprot id: A0A093FNK1
names: Similarity
messages: Belongs to the Bcl-2 family.

37040:HAUS3
gene id: 37040:HAUS3
uniprot id: A0A093FQQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS3 family.
messages: spindle

37040:SEC22C
gene id: 37040:SEC22C
uniprot id: A0A093FC06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

37040:LOC104254174
gene id: 37040:LOC104254174
uniprot id: A0A093H6W5
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

37040:SDC3
gene id: 37040:SDC3
uniprot id: A0A093ERV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

37040:PRKCD
gene id: 37040:PRKCD
uniprot id: A0A093HWB7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression.
messages: Cytoplasm
messages: Interacts with PDPK1 (via N-terminal region), RAD9A, CDCP1, MUC1 and VASP.
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.
messages: Nucleus
messages: perinuclear region

37040:EFEMP1
gene id: 37040:EFEMP1
uniprot id: A0A093H9A6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

37040:LPAR4
gene id: 37040:LPAR4
uniprot id: A0A093FLZ1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

37040:ACSL4
gene id: 37040:ACSL4
uniprot id: A0A093FIG5
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

37040:PCK1
gene id: 37040:PCK1
uniprot id: A0A093FFG0
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

37040:DHCR7
gene id: 37040:DHCR7
uniprot id: A0A093FK09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

37040:NDP
gene id: 37040:NDP
uniprot id: A0A093GY31
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

37040:CNOT8
gene id: 37040:CNOT8
uniprot id: A0A093FBR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

37040:ABRAXAS2
gene id: 37040:ABRAXAS2
uniprot id: A0A093FDI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM175 family. Abro1 subfamily.
messages: Nucleus
messages: spindle pole

37040:ELP4
gene id: 37040:ELP4
uniprot id: A0A093F3W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP4 family.
messages: Cytoplasm
messages: Nucleus

37040:EOGT
gene id: 37040:EOGT
uniprot id: A0A093HPG1
names: Similarity
messages: Belongs to the glycosyltransferase 61 family.

37040:HS3ST5
gene id: 37040:HS3ST5
uniprot id: A0A093FCD6
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

37040:TSPAN14
gene id: 37040:TSPAN14
uniprot id: A0A093FM10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

37040:SEMA5B
gene id: 37040:SEMA5B
uniprot id: A0A093H2S5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

37040:RPS11
gene id: 37040:RPS11
uniprot id: A0A093FQS6
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

37040:LOC104264625
gene id: 37040:LOC104264625
uniprot id: A0A093F3Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

37040:SENP8
gene id: 37040:SENP8
uniprot id: A0A093EYQ8
names: Similarity
messages: Belongs to the peptidase C48 family.

37040:SLC5A3
gene id: 37040:SLC5A3
uniprot id: A0A093FVW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

37040:PRDM1
gene id: 37040:PRDM1
uniprot id: A0A093EXU3
names: Subcellular Location Annotation
messages: Nucleus

37040:TMEM200A
gene id: 37040:TMEM200A
uniprot id: A0A093F3S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM200 family.
messages: Membrane

37040:CKMT2
gene id: 37040:CKMT2
uniprot id: A0A093HJC6
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

37040:TMEM229B
gene id: 37040:TMEM229B
uniprot id: A0A093FDU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM229 family.
messages: Membrane

37040:EMP2
gene id: 37040:EMP2
uniprot id: A0A093FHI8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Membrane raft
messages: Nucleus
messages: perinuclear region

37040:FHIP2A
gene id: 37040:FHIP2A
uniprot id: A0A093FR24
names: Similarity
messages: Belongs to the FHIP family.

37040:BAZ1B
gene id: 37040:BAZ1B
uniprot id: A0A093H2N9
names: Subcellular Location Annotation
messages: Nucleus

37040:DNAL4
gene id: 37040:DNAL4
uniprot id: A0A093EUK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

37040:GTF2E2
gene id: 37040:GTF2E2
uniprot id: A0A093EUV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

37040:ASPH
gene id: 37040:ASPH
uniprot id: A0A093F5K3
names: Similarity
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.

37040:HDX
gene id: 37040:HDX
uniprot id: A0A093EZY2
names: Subcellular Location Annotation
messages: Nucleus

37040:MPPED1
gene id: 37040:MPPED1
uniprot id: A0A093HWF3
names: Similarity
messages: Belongs to the UPF0046 family.

37040:RFLNB
gene id: 37040:RFLNB
uniprot id: A0A093FJQ1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Refilin family.
messages: Interacts with FLNA and FLNB.
messages: cytoskeleton

37040:INTS13
gene id: 37040:INTS13
uniprot id: A0A093HXP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the asunder family.
messages: Cytoplasm
messages: Nucleus

37040:GPX7
gene id: 37040:GPX7
uniprot id: A0A093H1B2
names: Similarity
messages: Belongs to the glutathione peroxidase family.

37040:MAFG
gene id: 37040:MAFG
uniprot id: A0A093F6S1
names: Similarity
messages: Belongs to the bZIP family. Maf subfamily.

37040:CEP55
gene id: 37040:CEP55
uniprot id: A0A093FDV9
names: Subcellular Location Annotation
messages: Cytoplasm

37040:RNF182
gene id: 37040:RNF182
uniprot id: A0A093F658
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with ATP6V0C.
messages: Membrane

37040:GTF2H1
gene id: 37040:GTF2H1
uniprot id: A0A093F943
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB1 family.
messages: Nucleus

37040:RCAN3
gene id: 37040:RCAN3
uniprot id: A0A093FAU8
names: Similarity
messages: Belongs to the RCAN family.

37040:LOC104257574
gene id: 37040:LOC104257574
uniprot id: A0A093FB86
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

37040:MAPK9
gene id: 37040:MAPK9
uniprot id: A0A093F6Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

37040:ZC3H15
gene id: 37040:ZC3H15
uniprot id: A0A093FAJ6
names: Similarity
messages: Belongs to the ZC3H15/TMA46 family.

37040:LOC104261650
gene id: 37040:LOC104261650
uniprot id: A0A093FL52
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

37040:PCSK1
gene id: 37040:PCSK1
uniprot id: A0A093ER99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
messages: Vesicle
messages: secretory vesicle

37040:LOC104262964
gene id: 37040:LOC104262964
uniprot id: A0A093FQH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

37040:TMEM86A
gene id: 37040:TMEM86A
uniprot id: A0A093EZ11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

37040:ZDHHC6
gene id: 37040:ZDHHC6
uniprot id: A0A093FLU6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

37040:B3GALT2
gene id: 37040:B3GALT2
uniprot id: A0A093FM42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

37040:ADA2
gene id: 37040:ADA2
uniprot id: A0A093FDR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.
messages: Secreted

37040:CALCA
gene id: 37040:CALCA
uniprot id: A0A093EZ52
names: Similarity
messages: Belongs to the calcitonin family.

37040:FAM53A
gene id: 37040:FAM53A
uniprot id: A0A093HPC3
names: Similarity
messages: Belongs to the FAM53 family.

37040:LOC104261805
gene id: 37040:LOC104261805
uniprot id: A0A093FWC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

37040:CCK
gene id: 37040:CCK
uniprot id: A0A093FJJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Secreted

37040:GPLD1
gene id: 37040:GPLD1
uniprot id: A0A093EYC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPLD1 family.
messages: Secreted

37040:LOC104257580
gene id: 37040:LOC104257580
uniprot id: A0A093FB95
names: Similarity
messages: Belongs to the histone H2B family.

37040:MMP2
gene id: 37040:MMP2
uniprot id: A0A093H6M0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: extracellular matrix

37040:TMEM35A
gene id: 37040:TMEM35A
uniprot id: A0A093H307
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

37040:INS
gene id: 37040:INS
uniprot id: A0A093F406
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
messages: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
messages: Secreted

37040:TRMT11
gene id: 37040:TRMT11
uniprot id: A0A093HGR2
names: Function
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.

37040:EPB41
gene id: 37040:EPB41
uniprot id: A0A093FK10
names: Subcellular Location Annotation
messages: Nucleus
messages: cell cortex
messages: cytoskeleton

37040:ST6GAL1
gene id: 37040:ST6GAL1
uniprot id: A0A093FNE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

37040:NFRKB
gene id: 37040:NFRKB
uniprot id: A0A093FBV6
names: Subcellular Location Annotation
messages: Nucleus

37040:NUDT12
gene id: 37040:NUDT12
uniprot id: A0A093EX92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Cytoplasmic granule
messages: Peroxisome

37040:CAPZA1
gene id: 37040:CAPZA1
uniprot id: A0A093FLD3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

37040:PLXNB2
gene id: 37040:PLXNB2
uniprot id: A0A093FPV2
names: Caution
names: Similarity
messages: Belongs to the plexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

37040:MFSD11
gene id: 37040:MFSD11
uniprot id: A0A093FHW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

37040:LRP8
gene id: 37040:LRP8
uniprot id: A0A093FBC6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

37040:BROX
gene id: 37040:BROX
uniprot id: A0A093EXM7
names: Similarity
messages: Belongs to the BROX family.

37040:DERL2
gene id: 37040:DERL2
uniprot id: A0A093F753
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

37040:EPYC
gene id: 37040:EPYC
uniprot id: A0A093FC36
names: Similarity
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

37040:PRKAB1
gene id: 37040:PRKAB1
uniprot id: A0A093EUE0
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

37040:LOC104259212
gene id: 37040:LOC104259212
uniprot id: A0A093FCU2
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

37040:LOC104264157
gene id: 37040:LOC104264157
uniprot id: A0A093EW13
names: Similarity
messages: Belongs to the globin family.

37040:MSTN
gene id: 37040:MSTN
uniprot id: A0A093FDT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts specifically as a negative regulator of skeletal muscle growth.
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Secreted

37040:RPL3
gene id: 37040:RPL3
uniprot id: A0A093FF37
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

37040:TENT5C
gene id: 37040:TENT5C
uniprot id: A0A093EY09
names: Similarity
messages: Belongs to the TENT family.

37040:ANAPC10
gene id: 37040:ANAPC10
uniprot id: A0A093FKI7
names: Function
names: Similarity
messages: Belongs to the APC10 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.

37040:PTPN4
gene id: 37040:PTPN4
uniprot id: A0A093FEA1
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

37040:MAGOH
gene id: 37040:MAGOH
uniprot id: A0A093FE56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

37040:MSH4
gene id: 37040:MSH4
uniprot id: A0A093FBJ4
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.

37040:MRPL23
gene id: 37040:MRPL23
uniprot id: A0A093F1C1
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

37040:CTLA4
gene id: 37040:CTLA4
uniprot id: A0A093FW35
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
messages: Membrane

37040:ODC1
gene id: 37040:ODC1
uniprot id: A0A093FCU3
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

37040:ALB
gene id: 37040:ALB
uniprot id: A0A093FHI9
names: Subcellular Location Annotation
messages: Secreted

37040:UBN1
gene id: 37040:UBN1
uniprot id: A0A093GYQ7
names: Similarity
messages: Belongs to the ubinuclein family.

37040:HSP90AB1
gene id: 37040:HSP90AB1
uniprot id: A0A093FKG6
names: Similarity
messages: Belongs to the heat shock protein 90 family.

37040:LOC104258919
gene id: 37040:LOC104258919
uniprot id: A0A093FLK1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

37040:NXPE3
gene id: 37040:NXPE3
uniprot id: A0A093F260
names: Similarity
messages: Belongs to the NXPE family.

37040:LOC104263084
gene id: 37040:LOC104263084
uniprot id: A0A093FQY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: cytoskeleton

37040:YPEL5
gene id: 37040:YPEL5
uniprot id: A0A093F1T4
names: Similarity
messages: Belongs to the yippee family.

37040:TDP1
gene id: 37040:TDP1
uniprot id: A0A093EUP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosyl-DNA phosphodiesterase family.
messages: Nucleus

37040:NIM1K
gene id: 37040:NIM1K
uniprot id: A0A093FBU8
names: Similarity
messages: Belongs to the protein kinase superfamily.

37040:LAMTOR3
gene id: 37040:LAMTOR3
uniprot id: A0A093HTJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR3 family.
messages: Endosome membrane
messages: Late endosome membrane

37040:CRHR2
gene id: 37040:CRHR2
uniprot id: A0A093F111
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Membrane

37040:TOLLIP
gene id: 37040:TOLLIP
uniprot id: A0A093FGE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tollip family.
messages: Cytoplasm

37040:CLDN20
gene id: 37040:CLDN20
uniprot id: A0A093F1N9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

37040:FBXO25
gene id: 37040:FBXO25
uniprot id: A0A093FAE0
names: Subcellular Location Annotation
messages: Nucleus

37040:ASPA
gene id: 37040:ASPA
uniprot id: A0A093FXY7
names: Cofactor
names: Similarity
messages: Belongs to the AspA/AstE family. Aspartoacylase subfamily.
messages: Binds 1 zinc ion per subunit.

37040:CCDC153
gene id: 37040:CCDC153
uniprot id: A0A093FNC6
names: Similarity
messages: Belongs to the UPF0610 family.

37040:ACER3
gene id: 37040:ACER3
uniprot id: A0A093FEX3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

37040:NR1H3
gene id: 37040:NR1H3
uniprot id: A0A093FZ05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

37040:CSTPP1
gene id: 37040:CSTPP1
uniprot id: A0A093HXF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSTPP1 family.
messages: cytoskeleton

37040:UBE2H
gene id: 37040:UBE2H
uniprot id: A0A093HDW1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

37040:PSMB7
gene id: 37040:PSMB7
uniprot id: A0A093HF73
names: Subcellular Location Annotation
messages: Nucleus

37040:PEMT
gene id: 37040:PEMT
uniprot id: A0A093FN00
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

37040:EFL1
gene id: 37040:EFL1
uniprot id: A0A093F1K3
names: Subcellular Location Annotation
messages: Nucleus

37040:LOC104257745
gene id: 37040:LOC104257745
uniprot id: A0A093EPL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

37040:LOC104261370
gene id: 37040:LOC104261370
uniprot id: A0A093FK78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

37040:ORMDL2
gene id: 37040:ORMDL2
uniprot id: A0A093FGI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane

37040:RPL30
gene id: 37040:RPL30
uniprot id: A0A093FD78
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

37040:LOC104257763
gene id: 37040:LOC104257763
uniprot id: A0A093FBP1
names: Subcellular Location Annotation
messages: Membrane

37040:DLST
gene id: 37040:DLST
uniprot id: A0A093FXK1
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

37040:B3GALT1
gene id: 37040:B3GALT1
uniprot id: A0A093G032
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

37040:STAM
gene id: 37040:STAM
uniprot id: A0A093I292
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane

37040:GNG2
gene id: 37040:GNG2
uniprot id: A0A093HB42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

37040:PTPN14
gene id: 37040:PTPN14
uniprot id: A0A093FRF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: cytoskeleton

37040:CER1
gene id: 37040:CER1
uniprot id: A0A093FYV4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

37040:SDHB
gene id: 37040:SDHB
uniprot id: A0A093HGN8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

37040:LDAF1
gene id: 37040:LDAF1
uniprot id: A0A093FB17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LDAF1 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Membrane

37040:SGCB
gene id: 37040:SGCB
uniprot id: A0A093HL33
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
messages: Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.
messages: cytoskeleton
messages: sarcolemma

37040:CPSF2
gene id: 37040:CPSF2
uniprot id: A0A093F723
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Nucleus

37040:LSM3
gene id: 37040:LSM3
uniprot id: A0A093EWQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

37040:LOC104261212
gene id: 37040:LOC104261212
uniprot id: A0A093FUD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMP-30/CGR1 family.
messages: Cytoplasm

37040:CAPN6
gene id: 37040:CAPN6
uniprot id: A0A093F3Z7
names: Similarity
messages: Belongs to the peptidase C2 family.

37040:GJA8
gene id: 37040:GJA8
uniprot id: A0A093F5P6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

37040:NPEPL1
gene id: 37040:NPEPL1
uniprot id: A0A093F5X7
names: Similarity
messages: Belongs to the peptidase M17 family.

37040:CDPF1
gene id: 37040:CDPF1
uniprot id: A0A093EWS8
names: Similarity
messages: Belongs to the CDPF1 family.

37040:SMAD1
gene id: 37040:SMAD1
uniprot id: A0A093FG34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

37040:GREM2
gene id: 37040:GREM2
uniprot id: A0A093HGS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAN family.
messages: Secreted

37040:SLC39A9
gene id: 37040:SLC39A9
uniprot id: A0A093EPD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Cell membrane
messages: Membrane
messages: Mitochondrion
messages: Nucleus
messages: Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.
messages: perinuclear region
messages: trans-Golgi network membrane

37040:SPDYA
gene id: 37040:SPDYA
uniprot id: A0A093F4C2
names: Similarity
messages: Belongs to the Speedy/Ringo family.

37040:PLPP3
gene id: 37040:PLPP3
uniprot id: A0A093HVM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

37040:PTGS2
gene id: 37040:PTGS2
uniprot id: A0A093EVG3
names: Caution
names: Similarity
messages: Belongs to the prostaglandin G/H synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

37040:EFTUD2
gene id: 37040:EFTUD2
uniprot id: A0A093FDU5
names: Subcellular Location Annotation
messages: Nucleus

37040:ZNF622
gene id: 37040:ZNF622
uniprot id: A0A093F584
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the REI1 family.
messages: Cytoplasm

37040:INTS12
gene id: 37040:INTS12
uniprot id: A0A093EZI0
names: Similarity
messages: Belongs to the Integrator subunit 12 family.

37040:LOC104264608
gene id: 37040:LOC104264608
uniprot id: A0A093GW54
names: Function
names: Similarity
messages: Belongs to the apovitellenin family.
messages: Protein component of the very low density lipoprotein (VLDL) of egg-laying females. Potent lipoprotein lipase inhibitor, preventing the loss of triglycerides from VLDL on their way from the liver to the growing oocytes.

37040:IRF8
gene id: 37040:IRF8
uniprot id: A0A093FL80
names: Subcellular Location Annotation
messages: Nucleus

37040:UHRF1
gene id: 37040:UHRF1
uniprot id: A0A093I1V0
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Multi domain E3 ubiquitin ligase that also plays a role in DNA methylation and histone modifications.
messages: Nucleus
messages: The YDG domain mediates the interaction with histone H3.
messages: The tudor-like regions specifically recognize and bind histone H3 unmethylated at 'Arg-2' (H3R2me0), while the PHD-type zinc finger specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3).

37040:ACE2
gene id: 37040:ACE2
uniprot id: A0A093FVX3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M2 family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Secreted
messages: cilium

37040:NIPA2
gene id: 37040:NIPA2
uniprot id: A0A093FTV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

37040:ATP5PF
gene id: 37040:ATP5PF
uniprot id: A0A093FRX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion
messages: Mitochondrion inner membrane

37040:EDC3
gene id: 37040:EDC3
uniprot id: A0A093HII9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: P-body

37040:TXNL4B
gene id: 37040:TXNL4B
uniprot id: A0A093FZL5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

37040:TEKT3
gene id: 37040:TEKT3
uniprot id: A0A093GYB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: flagellum

37040:RPL5
gene id: 37040:RPL5
uniprot id: A0A093G205
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

37040:ANAPC13
gene id: 37040:ANAPC13
uniprot id: A0A093ERQ3
names: Function
names: Similarity
messages: Belongs to the APC13 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

37040:UTS2
gene id: 37040:UTS2
uniprot id: A0A093EWP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urotensin-2 family.
messages: Secreted

37040:KCNA2
gene id: 37040:KCNA2
uniprot id: A0A093FSA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.
messages: Cell membrane
messages: Membrane

37040:C8H2orf76
gene id: 37040:C8H2orf76
uniprot id: A0A093H660
names: Similarity
messages: Belongs to the UPF0538 family.

37040:IFNG
gene id: 37040:IFNG
uniprot id: A0A093EP72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II (or gamma) interferon family.
messages: Homodimer.
messages: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
messages: Secreted

37040:EDEM3
gene id: 37040:EDEM3
uniprot id: A0A093ERD4
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

37040:GTF2A2
gene id: 37040:GTF2A2
uniprot id: A0A093FA31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.

37040:GNB4
gene id: 37040:GNB4
uniprot id: A0A093HIQ2
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

37040:USP40
gene id: 37040:USP40
uniprot id: A0A093F9N3
names: Similarity
messages: Belongs to the peptidase C19 family.

37040:SQLE
gene id: 37040:SQLE
uniprot id: A0A093FQ13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the squalene monooxygenase family.
messages: Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
messages: Endoplasmic reticulum membrane

37040:KCNE4
gene id: 37040:KCNE4
uniprot id: A0A093FB80
names: Similarity
messages: Belongs to the potassium channel KCNE family.

37040:LOC104254176
gene id: 37040:LOC104254176
uniprot id: A0A093F1U0
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

37040:BOD1
gene id: 37040:BOD1
uniprot id: A0A093FCH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BOD1 family.
messages: centrosome
messages: kinetochore

37040:UBIAD1
gene id: 37040:UBIAD1
uniprot id: A0A093F6P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Membrane

37040:ORMDL3
gene id: 37040:ORMDL3
uniprot id: A0A093F3C4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

37040:LOC104265118
gene id: 37040:LOC104265118
uniprot id: A0A093F5M5
names: Similarity
messages: Belongs to the FBPase class 1 family.

37040:STX18
gene id: 37040:STX18
uniprot id: A0A093FIA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.

37040:HDLBP
gene id: 37040:HDLBP
uniprot id: A0A093EY61
names: Subcellular Location Annotation
messages: Cytoplasm

37040:PKIA
gene id: 37040:PKIA
uniprot id: A0A093HPE5
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

37040:LOC104264363
gene id: 37040:LOC104264363
uniprot id: A0A093ERD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

37040:PRKCH
gene id: 37040:PRKCH
uniprot id: A0A093F1E0
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

37040:SLC26A9
gene id: 37040:SLC26A9
uniprot id: A0A093FQ76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Ion transporter that can act both as an ion channel and anion exchanger. Mainly acts as a chloride channel, which mediate uncoupled chloride anion transport in an alternate-access mechanism where a saturable binding site is alternately exposed to either one or the other side of the membrane. Also acts as a DIDS- and thiosulfate- sensitive anion exchanger the exchange of chloride for bicarbonate ions across the cell membrane.
messages: Membrane

37040:KCNMB1
gene id: 37040:KCNMB1
uniprot id: A0A093FJS7
names: Subcellular Location Annotation
messages: Membrane

37040:LYRM1
gene id: 37040:LYRM1
uniprot id: A0A093HBB8
names: Similarity
messages: Belongs to the complex I LYR family.

37040:SERPINF1
gene id: 37040:SERPINF1
uniprot id: A0A093EUM6
names: Similarity
messages: Belongs to the serpin family.

37040:TAGLN3
gene id: 37040:TAGLN3
uniprot id: A0A093GZJ6
names: Similarity
messages: Belongs to the calponin family.

37040:ACER2
gene id: 37040:ACER2
uniprot id: A0A093EW89
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

37040:ARHGDIA
gene id: 37040:ARHGDIA
uniprot id: A0A093I219
names: Similarity
messages: Belongs to the Rho GDI family.

37040:AGPAT3
gene id: 37040:AGPAT3
uniprot id: A0A093EZU9
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

37040:FBXO34
gene id: 37040:FBXO34
uniprot id: A0A093FF30
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

37040:UBA3
gene id: 37040:UBA3
uniprot id: A0A093ESB2
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.

37040:KDELR3
gene id: 37040:KDELR3
uniprot id: A0A093FIW6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

37040:RAB38
gene id: 37040:RAB38
uniprot id: A0A093G0S6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

37040:UCN3
gene id: 37040:UCN3
uniprot id: A0A093F8C7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
messages: Secreted
messages: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

37040:RPS14
gene id: 37040:RPS14
uniprot id: A0A093FMN3
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

37040:ATP6V1C1
gene id: 37040:ATP6V1C1
uniprot id: A0A093FE16
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

37040:LOC104253334
gene id: 37040:LOC104253334
uniprot id: A0A093H424
names: Similarity
messages: Belongs to the FBPase class 1 family.

37040:NPM1
gene id: 37040:NPM1
uniprot id: A0A093HG66
names: Similarity
messages: Belongs to the nucleoplasmin family.

37040:CSNK2A1
gene id: 37040:CSNK2A1
uniprot id: A0A093FU89
names: Similarity
messages: Belongs to the protein kinase superfamily.

37040:NFIL3
gene id: 37040:NFIL3
uniprot id: A0A093EYN1
names: Similarity
messages: Belongs to the bZIP family. NFIL3 subfamily.

37040:ATOH7
gene id: 37040:ATOH7
uniprot id: A0A093FC00
names: Subcellular Location Annotation
messages: Nucleus
messages: Perikaryon
messages: axon

37040:UNC93A
gene id: 37040:UNC93A
uniprot id: A0A093FAI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

37040:CORT
gene id: 37040:CORT
uniprot id: A0A093F4S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

37040:CEP63
gene id: 37040:CEP63
uniprot id: A0A093ERG0
names: Similarity
messages: Belongs to the CEP63 family.

37040:LOC104262390
gene id: 37040:LOC104262390
uniprot id: A0A093FNM0
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

37040:AP2M1
gene id: 37040:AP2M1
uniprot id: A0A093H1J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: coated pit

37040:DTD1
gene id: 37040:DTD1
uniprot id: A0A093F192
names: Similarity
messages: Belongs to the DTD family.

37040:NAA35
gene id: 37040:NAA35
uniprot id: A0A093FM75
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MAK10 family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.
messages: Cytoplasm

37040:TSHZ2
gene id: 37040:TSHZ2
uniprot id: A0A093FQN5
names: Similarity
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.

37040:F2
gene id: 37040:F2
uniprot id: A0A093FNR8
names: Caution
names: Function
names: Similarity
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.

37040:DACT2
gene id: 37040:DACT2
uniprot id: A0A093GVF8
names: Similarity
messages: Belongs to the dapper family.

37040:GPC4
gene id: 37040:GPC4
uniprot id: A0A093HM11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glypican family.
messages: Cell membrane
messages: Cell surface proteoglycan.

37040:HAPLN1
gene id: 37040:HAPLN1
uniprot id: A0A093FQ62
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

37040:OVOL2
gene id: 37040:OVOL2
uniprot id: A0A093H2R7
names: Subcellular Location Annotation
messages: Nucleus

37040:ATP6V1G3
gene id: 37040:ATP6V1G3
uniprot id: A0A093FJM4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

37040:TUBD1
gene id: 37040:TUBD1
uniprot id: A0A093EVR7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Nucleus
messages: centriole
messages: cilium

37040:NPY1R
gene id: 37040:NPY1R
uniprot id: A0A093FKC3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

37040:KCNE1
gene id: 37040:KCNE1
uniprot id: A0A093F7G6
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the potassium channel KCNE family.
messages: Cell membrane
messages: Membrane

37040:MFSD10
gene id: 37040:MFSD10
uniprot id: A0A093FGN0
names: Subcellular Location Annotation
messages: Membrane

37040:SMC5
gene id: 37040:SMC5
uniprot id: A0A093GY23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC5 subfamily.
messages: Chromosome
messages: Nucleus

37040:SNU13
gene id: 37040:SNU13
uniprot id: A0A093FNS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

37040:MMGT1
gene id: 37040:MMGT1
uniprot id: A0A093F599
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport.

37040:HS3ST6
gene id: 37040:HS3ST6
uniprot id: A0A093FKC0
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

37040:RPS6
gene id: 37040:RPS6
uniprot id: A0A093F3T2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

37040:ZBED4
gene id: 37040:ZBED4
uniprot id: A0A093H0P3
names: Subcellular Location Annotation
messages: Nucleus

37040:GPHB5
gene id: 37040:GPHB5
uniprot id: A0A093FCF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

37040:PCMTD2
gene id: 37040:PCMTD2
uniprot id: A0A093FLD6
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

37040:HAL
gene id: 37040:HAL
uniprot id: A0A093FYC4
names: Similarity
messages: Belongs to the PAL/histidase family.

37040:PRPH2
gene id: 37040:PRPH2
uniprot id: A0A093F2L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRPH2/ROM1 family.
messages: Membrane

37040:DRAM2
gene id: 37040:DRAM2
uniprot id: A0A093F492
names: Subcellular Location Annotation
messages: Membrane

37040:AFF4
gene id: 37040:AFF4
uniprot id: A0A093HR25
names: Similarity
messages: Belongs to the AF4 family.

37040:PEX12
gene id: 37040:PEX12
uniprot id: A0A093HGS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Membrane
messages: Peroxisome membrane

37040:PRPSAP2
gene id: 37040:PRPSAP2
uniprot id: A0A093FEC3
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

37040:IP6K2
gene id: 37040:IP6K2
uniprot id: A0A093HG14
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

37040:LACC1
gene id: 37040:LACC1
uniprot id: A0A093F4D8
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

37040:GNG4
gene id: 37040:GNG4
uniprot id: A0A093FEM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

37040:YIPF6
gene id: 37040:YIPF6
uniprot id: A0A093FCL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Membrane

37040:GCLM
gene id: 37040:GCLM
uniprot id: A0A093FKR2
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.
messages: Heterodimer of a catalytic heavy chain and a regulatory light chain.

37040:KPNA1
gene id: 37040:KPNA1
uniprot id: A0A093F0R9
names: Similarity
messages: Belongs to the importin alpha family.

37040:RPS2
gene id: 37040:RPS2
uniprot id: A0A093F0H1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Nucleus

37040:INTS9
gene id: 37040:INTS9
uniprot id: A0A093FC08
names: Subcellular Location Annotation
messages: Nucleus

37040:MCM8
gene id: 37040:MCM8
uniprot id: A0A093FBH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Nucleus

37040:FAM167A
gene id: 37040:FAM167A
uniprot id: A0A093FWN5
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

37040:COPB1
gene id: 37040:COPB1
uniprot id: A0A093EMW8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

37040:SLC13A4
gene id: 37040:SLC13A4
uniprot id: A0A093HDP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

37040:NEUROD6
gene id: 37040:NEUROD6
uniprot id: A0A093FBU0
names: Subcellular Location Annotation
messages: Nucleus

37040:ERGIC1
gene id: 37040:ERGIC1
uniprot id: A0A093HBF4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

37040:LOC104254247
gene id: 37040:LOC104254247
uniprot id: A0A093H734
names: Function
names: Similarity
messages: Belongs to the parvalbumin family.
messages: In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

37040:TNIP2
gene id: 37040:TNIP2
uniprot id: A0A093H407
names: Subcellular Location Annotation
messages: Cytoplasm

37040:SLC16A14
gene id: 37040:SLC16A14
uniprot id: A0A093HP62
names: Subcellular Location Annotation
messages: Membrane

37040:GFOD2
gene id: 37040:GFOD2
uniprot id: A0A093FWW2
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

37040:SGCD
gene id: 37040:SGCD
uniprot id: A0A093G0J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sarcoglycan beta/delta/gamma/zeta family.
messages: cytoskeleton
messages: sarcolemma

37040:CALHM2
gene id: 37040:CALHM2
uniprot id: A0A093EX13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

37040:TM4SF18
gene id: 37040:TM4SF18
uniprot id: A0A093FQZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

37040:EMC8
gene id: 37040:EMC8
uniprot id: A0A093HY80
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

37040:MTMR6
gene id: 37040:MTMR6
uniprot id: A0A093F1G1
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

37040:CIAPIN1
gene id: 37040:CIAPIN1
uniprot id: A0A093FCW4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion intermembrane space
messages: Monomer. Interacts with NDOR1. Interacts with CHCHD4.
messages: Nucleus
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

37040:LOC104254958
gene id: 37040:LOC104254958
uniprot id: A0A093F1A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

37040:IL7R
gene id: 37040:IL7R
uniprot id: A0A093H3E6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Membrane
messages: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
messages: The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.

37040:KIN
gene id: 37040:KIN
uniprot id: A0A093FZ47
names: Similarity
messages: Belongs to the KIN17 family.

37040:EDNRA
gene id: 37040:EDNRA
uniprot id: A0A093HEA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with HDAC7 and KAT5.
messages: Membrane
messages: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

37040:LOC104260586
gene id: 37040:LOC104260586
uniprot id: A0A093FSD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dienelactone hydrolase family.
messages: cytosol

37040:MLLT11
gene id: 37040:MLLT11
uniprot id: A0A093F4W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLLT11 family.
messages: Nucleus
messages: centrosome

37040:SLC24A3
gene id: 37040:SLC24A3
uniprot id: A0A093H3V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

37040:ERGIC2
gene id: 37040:ERGIC2
uniprot id: A0A093FPI1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

37040:FDFT1
gene id: 37040:FDFT1
uniprot id: A0A093F238
names: Function
names: Similarity
messages: Belongs to the phytoene/squalene synthase family.
messages: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.

37040:HVCN1
gene id: 37040:HVCN1
uniprot id: A0A093H6L5
names: Subcellular Location Annotation
messages: Membrane

37040:REV1
gene id: 37040:REV1
uniprot id: A0A093F548
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-Y family.
messages: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
messages: Nucleus

37040:SLC25A20
gene id: 37040:SLC25A20
uniprot id: A0A093F7B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

37040:GUK1
gene id: 37040:GUK1
uniprot id: A0A093F0U0
names: Similarity
messages: Belongs to the guanylate kinase family.

37040:MAPK8
gene id: 37040:MAPK8
uniprot id: A0A093FVT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

37040:LOC104256103
gene id: 37040:LOC104256103
uniprot id: A0A093F7C8
names: Similarity
messages: Belongs to the cytochrome P450 family.

37040:CNR1
gene id: 37040:CNR1
uniprot id: A0A093F777
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled receptor for cannabinoids. Mediates many cannabinoid-induced effects in the central nervous system (CNS), as well as in peripheral tissues. Signaling typically involves reduction in cyclic AMP.
messages: Membrane
messages: Mitochondrion outer membrane
messages: Presynapse
messages: Synapse
messages: axon

37040:ALDOB
gene id: 37040:ALDOB
uniprot id: A0A093F4M7
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

37040:TP53INP1
gene id: 37040:TP53INP1
uniprot id: A0A093F5E3
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

37040:APOD
gene id: 37040:APOD
uniprot id: A0A093FFH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

37040:ALG12
gene id: 37040:ALG12
uniprot id: A0A093F2C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

37040:BASP1
gene id: 37040:BASP1
uniprot id: A0A093EN09
names: Similarity
messages: Belongs to the BASP1 family.

37040:FYN
gene id: 37040:FYN
uniprot id: A0A093FDT6
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.

37040:SLC6A15
gene id: 37040:SLC6A15
uniprot id: A0A093FKN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily.
messages: Membrane

37040:PRKCA
gene id: 37040:PRKCA
uniprot id: A0A093FJX9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion membrane
messages: Nucleus

37040:IRF2
gene id: 37040:IRF2
uniprot id: A0A093FAY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Nucleus

37040:LOC104262983
gene id: 37040:LOC104262983
uniprot id: A0A093FQK4
names: Similarity
messages: Belongs to the cytochrome P450 family.

37040:BOK
gene id: 37040:BOK
uniprot id: A0A093FRI3
names: Similarity
messages: Belongs to the Bcl-2 family.

37040:SPARC
gene id: 37040:SPARC
uniprot id: A0A093FUA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
messages: Belongs to the SPARC family.
messages: Membrane
messages: basement membrane

37040:SPI1
gene id: 37040:SPI1
uniprot id: A0A093F893
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

37040:SORD
gene id: 37040:SORD
uniprot id: A0A093FUF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Mitochondrion membrane
messages: flagellum

37040:GNB3
gene id: 37040:GNB3
uniprot id: A0A093HG52
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

37040:TRAF6
gene id: 37040:TRAF6
uniprot id: A0A093F1N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family. A subfamily.
messages: Lipid droplet
messages: Nucleus
messages: cell cortex

37040:C1GALT1
gene id: 37040:C1GALT1
uniprot id: A0A093FRI0
names: Subcellular Location Annotation
messages: Membrane

37040:IL12B
gene id: 37040:IL12B
uniprot id: A0A093FR25
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-12B family.
messages: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12.
messages: Secreted

37040:TMEM41A
gene id: 37040:TMEM41A
uniprot id: A0A093F2U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

37040:TRAF5
gene id: 37040:TRAF5
uniprot id: A0A093H522
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

37040:BLCAP
gene id: 37040:BLCAP
uniprot id: A0A093FWM6
names: Similarity
messages: Belongs to the BLCAP family.

37040:STX17
gene id: 37040:STX17
uniprot id: A0A093F9Q9
names: Similarity
messages: Belongs to the syntaxin family.

37040:CHRNA9
gene id: 37040:CHRNA9
uniprot id: A0A093F0E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

37040:MED7
gene id: 37040:MED7
uniprot id: A0A093FFI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

37040:TARDBP
gene id: 37040:TARDBP
uniprot id: A0A093FJ08
names: Subcellular Location Annotation
messages: Nucleus

37040:GIMD1
gene id: 37040:GIMD1
uniprot id: A0A093G0L5
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

37040:ATP6V1C2
gene id: 37040:ATP6V1C2
uniprot id: A0A093FG01
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

37040:TNFAIP1
gene id: 37040:TNFAIP1
uniprot id: A0A093HRR0
names: Similarity
messages: Belongs to the BACURD family.

37040:ATG5
gene id: 37040:ATG5
uniprot id: A0A093H624
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated with ATG12.
messages: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.
messages: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.
messages: Preautophagosomal structure membrane

37040:CHRM2
gene id: 37040:CHRM2
uniprot id: A0A093F4P7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.