368408:TPEN RS01630
gene id: 368408:TPEN_RS01630
uniprot id: A1RX00
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

368408:TPEN RS05595
gene id: 368408:TPEN_RS05595
uniprot id: A1RZ56
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS08740
gene id: 368408:TPEN_RS08740
uniprot id: A1S0X9
names: Similarity
messages: Belongs to the peptidase S8 family.

368408:TPEN RS03320
gene id: 368408:TPEN_RS03320
uniprot id: A1RXW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

368408:TPEN RS07465
gene id: 368408:TPEN_RS07465
uniprot id: A1S074
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

368408:TPEN RS00465
gene id: 368408:TPEN_RS00465
uniprot id: A1RWC4
names: Similarity
messages: Belongs to the AOR/FOR family.

368408:TPEN RS04265
gene id: 368408:TPEN_RS04265
uniprot id: A1RYE7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

368408:TPEN RS01210
gene id: 368408:TPEN_RS01210
uniprot id: A1RWS3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

368408:TPEN RS02675
gene id: 368408:TPEN_RS02675
uniprot id: A1RXJ1
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

368408:TPEN RS05180
gene id: 368408:TPEN_RS05180
uniprot id: A1RYX4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

368408:TPEN RS05940
gene id: 368408:TPEN_RS05940
uniprot id: A1RZC3
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

368408:TPEN RS08285
gene id: 368408:TPEN_RS08285
uniprot id: A1S0N7
names: Similarity
messages: Belongs to the FGGY kinase family.

368408:TPEN RS02955
gene id: 368408:TPEN_RS02955
uniprot id: A1RXP8
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

368408:TPEN RS02295
gene id: 368408:TPEN_RS02295
uniprot id: A1RXC4
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS02535
gene id: 368408:TPEN_RS02535
uniprot id: A1RXG6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

368408:TPEN RS02095
gene id: 368408:TPEN_RS02095
uniprot id: A1RX87
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

368408:TPEN RS02310
gene id: 368408:TPEN_RS02310
uniprot id: A1RXC7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

368408:TPEN RS01435
gene id: 368408:TPEN_RS01435
uniprot id: A1RWW5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

368408:TPEN RS00065
gene id: 368408:TPEN_RS00065
uniprot id: A1RW43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

368408:TPEN RS00730
gene id: 368408:TPEN_RS00730
uniprot id: A1RWH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

368408:TPEN RS03345
gene id: 368408:TPEN_RS03345
uniprot id: A1RXW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

368408:TPEN RS02830
gene id: 368408:TPEN_RS02830
uniprot id: A1RXM2
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

368408:TPEN RS08010
gene id: 368408:TPEN_RS08010
uniprot id: A1S0I2
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

368408:TPEN RS05390
gene id: 368408:TPEN_RS05390
uniprot id: A1RZ16
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

368408:TPEN RS09370
gene id: 368408:TPEN_RS09370
uniprot id: A1S1A4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

368408:TPEN RS04125
gene id: 368408:TPEN_RS04125
uniprot id: A1RYC0
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

368408:TPEN RS00135
gene id: 368408:TPEN_RS00135
uniprot id: A1RW56
names: Similarity
messages: Belongs to the glutaredoxin family.

368408:TPEN RS07645
gene id: 368408:TPEN_RS07645
uniprot id: A1S0B0
names: Similarity
messages: Belongs to the UPF0173 family.

368408:TPEN RS02165
gene id: 368408:TPEN_RS02165
uniprot id: A1RXA1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

368408:TPEN RS00675
gene id: 368408:TPEN_RS00675
uniprot id: A1RWG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

368408:TPEN RS05845
gene id: 368408:TPEN_RS05845
uniprot id: A1RZA5
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS01955
gene id: 368408:TPEN_RS01955
uniprot id: A1RX63
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

368408:TPEN RS02900
gene id: 368408:TPEN_RS02900
uniprot id: A1RXN6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

368408:TPEN RS01205
gene id: 368408:TPEN_RS01205
uniprot id: A1RWS2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

368408:TPEN RS04155
gene id: 368408:TPEN_RS04155
uniprot id: A1RYC6
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS09065
gene id: 368408:TPEN_RS09065
uniprot id: A1S143
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

368408:TPEN RS01825
gene id: 368408:TPEN_RS01825
uniprot id: A1RX37
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

368408:TPEN RS03150
gene id: 368408:TPEN_RS03150
uniprot id: A1RXS8
names: Similarity
messages: Belongs to the UPF0047 family.

368408:TPEN RS01445
gene id: 368408:TPEN_RS01445
uniprot id: A1RWW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

368408:TPEN RS05775
gene id: 368408:TPEN_RS05775
uniprot id: A1RZ91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

368408:TPEN RS03015
gene id: 368408:TPEN_RS03015
uniprot id: A1RXQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

368408:TPEN RS06770
gene id: 368408:TPEN_RS06770
uniprot id: A1RZT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

368408:TPEN RS05415
gene id: 368408:TPEN_RS05415
uniprot id: A1RZ21
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

368408:TPEN RS03515
gene id: 368408:TPEN_RS03515
uniprot id: A1RY02
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

368408:TPEN RS05955
gene id: 368408:TPEN_RS05955
uniprot id: A1RZC6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

368408:TPEN RS08365
gene id: 368408:TPEN_RS08365
uniprot id: A1S0Q3
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

368408:TPEN RS00035
gene id: 368408:TPEN_RS00035
uniprot id: A1RW37
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS04675
gene id: 368408:TPEN_RS04675
uniprot id: A1RYM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

368408:TPEN RS03210
gene id: 368408:TPEN_RS03210
uniprot id: A1RXU0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

368408:TPEN RS00485
gene id: 368408:TPEN_RS00485
uniprot id: A1RWC8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).

368408:TPEN RS08770
gene id: 368408:TPEN_RS08770
uniprot id: A1S0Y5
names: Similarity
messages: Belongs to the UDPGP type 2 family.

368408:TPEN RS05660
gene id: 368408:TPEN_RS05660
uniprot id: A1RZ69
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS03535
gene id: 368408:TPEN_RS03535
uniprot id: A1RY06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

368408:TPEN RS08065
gene id: 368408:TPEN_RS08065
uniprot id: A1S0J3
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS07215
gene id: 368408:TPEN_RS07215
uniprot id: A1S026
names: Cofactor
messages: Binds 4 [4Fe-4S] clusters per subunit.

368408:TPEN RS01345
gene id: 368408:TPEN_RS01345
uniprot id: A1RWU9
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

368408:TPEN RS03425
gene id: 368408:TPEN_RS03425
uniprot id: A1RXY3
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

368408:TPEN RS01715
gene id: 368408:TPEN_RS01715
uniprot id: A1RX16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

368408:TPEN RS00705
gene id: 368408:TPEN_RS00705
uniprot id: A1RWH2
names: Similarity
messages: Belongs to the SurE nucleotidase family.

368408:TPEN RS09070
gene id: 368408:TPEN_RS09070
uniprot id: A1S144
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS08060
gene id: 368408:TPEN_RS08060
uniprot id: A1S0J2
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS01985
gene id: 368408:TPEN_RS01985
uniprot id: A1RX69
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

368408:TPEN RS07450
gene id: 368408:TPEN_RS07450
uniprot id: A1S071
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

368408:TPEN RS01080
gene id: 368408:TPEN_RS01080
uniprot id: A1RWP7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

368408:TPEN RS04295
gene id: 368408:TPEN_RS04295
uniprot id: A1RYF3
names: Similarity
messages: Belongs to the band 7/mec-2 family.

368408:TPEN RS05915
gene id: 368408:TPEN_RS05915
uniprot id: A1RZB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

368408:TPEN RS05980
gene id: 368408:TPEN_RS05980
uniprot id: A1RZD1
names: Similarity
messages: Belongs to the CTP synthase family.

368408:TPEN RS07915
gene id: 368408:TPEN_RS07915
uniprot id: A1S0G3
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS03695
gene id: 368408:TPEN_RS03695
uniprot id: A1RY36
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

368408:TPEN RS02585
gene id: 368408:TPEN_RS02585
uniprot id: A1RXH6
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

368408:TPEN RS05800
gene id: 368408:TPEN_RS05800
uniprot id: A1RZ96
names: Caution
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

368408:TPEN RS05275
gene id: 368408:TPEN_RS05275
uniprot id: A1RYZ3
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

368408:TPEN RS08870
gene id: 368408:TPEN_RS08870
uniprot id: A1S104
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS06340
gene id: 368408:TPEN_RS06340
uniprot id: A1RZK4
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.

368408:TPEN RS03585
gene id: 368408:TPEN_RS03585
uniprot id: A1RY15
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

368408:TPEN RS05450
gene id: 368408:TPEN_RS05450
uniprot id: A1RZ28
names: Similarity
messages: Belongs to the PstS family.

368408:TPEN RS06205
gene id: 368408:TPEN_RS06205
uniprot id: A1RZH7
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS01325
gene id: 368408:TPEN_RS01325
uniprot id: A1RWU5
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

368408:TPEN RS03245
gene id: 368408:TPEN_RS03245
uniprot id: A1RXU7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

368408:TPEN RS00335
gene id: 368408:TPEN_RS00335
uniprot id: A1RW96
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS02125
gene id: 368408:TPEN_RS02125
uniprot id: A1RX93
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

368408:TPEN RS07710
gene id: 368408:TPEN_RS07710
uniprot id: A1S0C3
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS02510
gene id: 368408:TPEN_RS02510
uniprot id: A1RXG2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

368408:TPEN RS03260
gene id: 368408:TPEN_RS03260
uniprot id: A1RXV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

368408:TPEN RS06055
gene id: 368408:TPEN_RS06055
uniprot id: A1RZE6
names: Subunit
messages: Homodimer.

368408:TPEN RS07425
gene id: 368408:TPEN_RS07425
uniprot id: A1S066
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

368408:TPEN RS08375
gene id: 368408:TPEN_RS08375
uniprot id: A1S0Q5
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS07445
gene id: 368408:TPEN_RS07445
uniprot id: A1S070
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

368408:TPEN RS04865
gene id: 368408:TPEN_RS04865
uniprot id: A1RYR3
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

368408:TPEN RS07650
gene id: 368408:TPEN_RS07650
uniprot id: A1S0B1
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

368408:TPEN RS02335
gene id: 368408:TPEN_RS02335
uniprot id: A1RXD2
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

368408:TPEN RS05950
gene id: 368408:TPEN_RS05950
uniprot id: A1RZC5
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

368408:TPEN RS01830
gene id: 368408:TPEN_RS01830
uniprot id: A1RX38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

368408:TPEN RS03010
gene id: 368408:TPEN_RS03010
uniprot id: A1RXQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

368408:TPEN RS02000
gene id: 368408:TPEN_RS02000
uniprot id: A1RX72
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

368408:TPEN RS05755
gene id: 368408:TPEN_RS05755
uniprot id: A1RZ87
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS07565
gene id: 368408:TPEN_RS07565
uniprot id: A1S094
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

368408:TPEN RS07980
gene id: 368408:TPEN_RS07980
uniprot id: A1S0H6
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS02885
gene id: 368408:TPEN_RS02885
uniprot id: A1RXN3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

368408:TPEN RS01840
gene id: 368408:TPEN_RS01840
uniprot id: A1RX40
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

368408:TPEN RS02525
gene id: 368408:TPEN_RS02525
uniprot id: A1RXG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

368408:TPEN RS04910
gene id: 368408:TPEN_RS04910
uniprot id: A1RYS2
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

368408:TPEN RS03290
gene id: 368408:TPEN_RS03290
uniprot id: A1RXV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Membrane

368408:TPEN RS09025
gene id: 368408:TPEN_RS09025
uniprot id: A1S135
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

368408:TPEN RS01000
gene id: 368408:TPEN_RS01000
uniprot id: A1RWN1
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

368408:TPEN RS00270
gene id: 368408:TPEN_RS00270
uniprot id: A1RW83
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS07920
gene id: 368408:TPEN_RS07920
uniprot id: A1S0G4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

368408:TPEN RS04340
gene id: 368408:TPEN_RS04340
uniprot id: A1RYG4
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

368408:TPEN RS02665
gene id: 368408:TPEN_RS02665
uniprot id: A1RXI9
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

368408:TPEN RS05705
gene id: 368408:TPEN_RS05705
uniprot id: A1RZ78
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS06430
gene id: 368408:TPEN_RS06430
uniprot id: A1RZM2
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

368408:TPEN RS03950
gene id: 368408:TPEN_RS03950
uniprot id: A1RY85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

368408:TPEN RS04605
gene id: 368408:TPEN_RS04605
uniprot id: A1RYL5
names: Similarity
messages: Belongs to the FGGY kinase family.

368408:TPEN RS04210
gene id: 368408:TPEN_RS04210
uniprot id: A1RYD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

368408:TPEN RS06485
gene id: 368408:TPEN_RS06485
uniprot id: A1RZN3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 2 family.
messages: Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

368408:TPEN RS00855
gene id: 368408:TPEN_RS00855
uniprot id: A1RWK2
names: Similarity
messages: Belongs to the carbamate kinase family.

368408:TPEN RS02685
gene id: 368408:TPEN_RS02685
uniprot id: A1RXJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

368408:TPEN RS07840
gene id: 368408:TPEN_RS07840
uniprot id: A1S0E8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

368408:TPEN RS00880
gene id: 368408:TPEN_RS00880
uniprot id: A1RWK7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

368408:TPEN RS02440
gene id: 368408:TPEN_RS02440
uniprot id: A1RXE9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

368408:TPEN RS01625
gene id: 368408:TPEN_RS01625
uniprot id: A1RWZ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

368408:TPEN RS03050
gene id: 368408:TPEN_RS03050
uniprot id: A1RXR1
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

368408:TPEN RS02690
gene id: 368408:TPEN_RS02690
uniprot id: A1RXJ4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.

368408:TPEN RS01740
gene id: 368408:TPEN_RS01740
uniprot id: A1RX21
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

368408:TPEN RS02810
gene id: 368408:TPEN_RS02810
uniprot id: A1RXL8
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

368408:TPEN RS02600
gene id: 368408:TPEN_RS02600
uniprot id: A1RXH9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

368408:TPEN RS03155
gene id: 368408:TPEN_RS03155
uniprot id: A1RXS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

368408:TPEN RS05935
gene id: 368408:TPEN_RS05935
uniprot id: A1RZC2
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

368408:TPEN RS00580
gene id: 368408:TPEN_RS00580
uniprot id: A1RWE7
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

368408:TPEN RS08880
gene id: 368408:TPEN_RS08880
uniprot id: A1S106
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS03395
gene id: 368408:TPEN_RS03395
uniprot id: A1RXX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

368408:TPEN RS03885
gene id: 368408:TPEN_RS03885
uniprot id: A1RY72
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

368408:TPEN RS02575
gene id: 368408:TPEN_RS02575
uniprot id: A1RXH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Nucleus

368408:TPEN RS03955
gene id: 368408:TPEN_RS03955
uniprot id: A1RY86
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

368408:TPEN RS06255
gene id: 368408:TPEN_RS06255
uniprot id: A1RZI6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

368408:TPEN RS03265
gene id: 368408:TPEN_RS03265
uniprot id: A1RXV2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

368408:TPEN RS04105
gene id: 368408:TPEN_RS04105
uniprot id: A1RYB6
names: Similarity
messages: Belongs to the UPF0273 family.

368408:TPEN RS02135
gene id: 368408:TPEN_RS02135
uniprot id: A1RX95
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

368408:TPEN RS02805
gene id: 368408:TPEN_RS02805
uniprot id: A1RXL7
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

368408:TPEN RS02515
gene id: 368408:TPEN_RS02515
uniprot id: A1RXG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

368408:TPEN RS04040
gene id: 368408:TPEN_RS04040
uniprot id: A1RYA3
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer composed of an alpha and a beta subunit.
messages: Heterodimer of the IorA and IorB subunits.

368408:TPEN RS03215
gene id: 368408:TPEN_RS03215
uniprot id: A1RXU1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

368408:TPEN RS00050
gene id: 368408:TPEN_RS00050
uniprot id: A1RW40
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

368408:TPEN RS01415
gene id: 368408:TPEN_RS01415
uniprot id: A1RWW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

368408:TPEN RS00975
gene id: 368408:TPEN_RS00975
uniprot id: A1RWM6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

368408:TPEN RS06190
gene id: 368408:TPEN_RS06190
uniprot id: A1RZH4
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

368408:TPEN RS00960
gene id: 368408:TPEN_RS00960
uniprot id: A1RWM3
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS05360
gene id: 368408:TPEN_RS05360
uniprot id: A1RZ10
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.

368408:TPEN RS02200
gene id: 368408:TPEN_RS02200
uniprot id: A1RXA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

368408:TPEN RS00220
gene id: 368408:TPEN_RS00220
uniprot id: A1RW73
names: Similarity
messages: Belongs to the peptidase U62 family.

368408:TPEN RS02210
gene id: 368408:TPEN_RS02210
uniprot id: A1RXB0
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

368408:TPEN RS02595
gene id: 368408:TPEN_RS02595
uniprot id: A1RXH8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Binds two Mg(2+) per subunit.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome.

368408:TPEN RS08265
gene id: 368408:TPEN_RS08265
uniprot id: A1S0N3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

368408:TPEN RS08050
gene id: 368408:TPEN_RS08050
uniprot id: A1S0J0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

368408:TPEN RS01405
gene id: 368408:TPEN_RS01405
uniprot id: A1RWV9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

368408:TPEN RS05625
gene id: 368408:TPEN_RS05625
uniprot id: A1RZ62
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.

368408:TPEN RS08105
gene id: 368408:TPEN_RS08105
uniprot id: A1S0K1
names: Similarity
messages: Belongs to the peptidase C15 family.

368408:TPEN RS00920
gene id: 368408:TPEN_RS00920
uniprot id: A1RWL5
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS02640
gene id: 368408:TPEN_RS02640
uniprot id: A1RXI5
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

368408:TPEN RS06285
gene id: 368408:TPEN_RS06285
uniprot id: A1RZJ3
names: Similarity
messages: Belongs to the peptidase M1 family.

368408:TPEN RS03330
gene id: 368408:TPEN_RS03330
uniprot id: A1RXW6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

368408:TPEN RS05990
gene id: 368408:TPEN_RS05990
uniprot id: A1RZD3
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS06050
gene id: 368408:TPEN_RS06050
uniprot id: A1RZE5
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS09300
gene id: 368408:TPEN_RS09300
uniprot id: A1S190
names: Similarity
messages: Belongs to the peptidase S49 family.

368408:TPEN RS04400
gene id: 368408:TPEN_RS04400
uniprot id: A1RYH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

368408:TPEN RS04540
gene id: 368408:TPEN_RS04540
uniprot id: A1RYK3
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

368408:TPEN RS01105
gene id: 368408:TPEN_RS01105
uniprot id: A1RWQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

368408:TPEN RS02565
gene id: 368408:TPEN_RS02565
uniprot id: A1RXH2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

368408:TPEN RS01185
gene id: 368408:TPEN_RS01185
uniprot id: A1RWR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

368408:TPEN RS09360
gene id: 368408:TPEN_RS09360
uniprot id: A1S1A2
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family.

368408:TPEN RS07235
gene id: 368408:TPEN_RS07235
uniprot id: A1S030
names: Similarity
messages: Belongs to the AOR/FOR family.

368408:TPEN RS03445
gene id: 368408:TPEN_RS03445
uniprot id: A1RXY8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

368408:TPEN RS05960
gene id: 368408:TPEN_RS05960
uniprot id: A1RZC7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

368408:TPEN RS08240
gene id: 368408:TPEN_RS08240
uniprot id: A1S0M8
names: Similarity
messages: Belongs to the HypE family.

368408:TPEN RS08465
gene id: 368408:TPEN_RS08465
uniprot id: A1S0S3
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS06295
gene id: 368408:TPEN_RS06295
uniprot id: A1RZJ5
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

368408:TPEN RS01920
gene id: 368408:TPEN_RS01920
uniprot id: A1RX56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

368408:TPEN RS08985
gene id: 368408:TPEN_RS08985
uniprot id: A1S127
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

368408:TPEN RS05920
gene id: 368408:TPEN_RS05920
uniprot id: A1RZB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

368408:TPEN RS08290
gene id: 368408:TPEN_RS08290
uniprot id: A1S0N8
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

368408:TPEN RS06535
gene id: 368408:TPEN_RS06535
uniprot id: A1RZP2
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS00020
gene id: 368408:TPEN_RS00020
uniprot id: A1RW34
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS08415
gene id: 368408:TPEN_RS08415
uniprot id: A1S0R3
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

368408:TPEN RS08595
gene id: 368408:TPEN_RS08595
uniprot id: A1S0U9
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS03450
gene id: 368408:TPEN_RS03450
uniprot id: A1RXY9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

368408:TPEN RS02645
gene id: 368408:TPEN_RS02645
uniprot id: A1RXI6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

368408:TPEN RS03220
gene id: 368408:TPEN_RS03220
uniprot id: A1RXU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.

368408:TPEN RS08120
gene id: 368408:TPEN_RS08120
uniprot id: A1S0K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

368408:TPEN RS08025
gene id: 368408:TPEN_RS08025
uniprot id: A1S0I5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

368408:TPEN RS06950
gene id: 368408:TPEN_RS06950
uniprot id: A1RZX3
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

368408:TPEN RS02580
gene id: 368408:TPEN_RS02580
uniprot id: A1RXH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

368408:TPEN RS02555
gene id: 368408:TPEN_RS02555
uniprot id: A1RXH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

368408:TPEN RS02815
gene id: 368408:TPEN_RS02815
uniprot id: A1RXL9
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

368408:TPEN RS01010
gene id: 368408:TPEN_RS01010
uniprot id: A1RWN3
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS08410
gene id: 368408:TPEN_RS08410
uniprot id: A1S0R2
names: Cofactor
names: Function
names: Similarity
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity).
messages: Binds 1 potassium ion per subunit.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.

368408:TPEN RS00835
gene id: 368408:TPEN_RS00835
uniprot id: A1RWJ8
names: Similarity
messages: Belongs to the peptidase U62 family.

368408:TPEN RS09130
gene id: 368408:TPEN_RS09130
uniprot id: A1S156
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.

368408:TPEN RS01050
gene id: 368408:TPEN_RS01050
uniprot id: A1RWP1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

368408:TPEN RS02290
gene id: 368408:TPEN_RS02290
uniprot id: A1RXC3
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

368408:TPEN RS07580
gene id: 368408:TPEN_RS07580
uniprot id: A1S097
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

368408:TPEN RS01660
gene id: 368408:TPEN_RS01660
uniprot id: A1RX05
names: Similarity
messages: Belongs to the glutaredoxin family.

368408:TPEN RS01680
gene id: 368408:TPEN_RS01680
uniprot id: A1RX09
names: Similarity
messages: Belongs to the pyruvate kinase family.

368408:TPEN RS05710
gene id: 368408:TPEN_RS05710
uniprot id: A1RZ79
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

368408:TPEN RS01425
gene id: 368408:TPEN_RS01425
uniprot id: A1RWW3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

368408:TPEN RS03360
gene id: 368408:TPEN_RS03360
uniprot id: A1RXX1
names: Similarity
messages: Belongs to the ZPR1 family.

368408:TPEN RS06435
gene id: 368408:TPEN_RS06435
uniprot id: A1RZM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

368408:TPEN RS06780
gene id: 368408:TPEN_RS06780
uniprot id: A1RZT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

368408:TPEN RS08855
gene id: 368408:TPEN_RS08855
uniprot id: A1S101
names: Similarity
messages: Belongs to the HepT RNase toxin family.

368408:TPEN RS04580
gene id: 368408:TPEN_RS04580
uniprot id: A1RYL1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

368408:TPEN RS02540
gene id: 368408:TPEN_RS02540
uniprot id: A1RXG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

368408:TPEN RS05445
gene id: 368408:TPEN_RS05445
uniprot id: A1RZ27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

368408:TPEN RS03110
gene id: 368408:TPEN_RS03110
uniprot id: A1RXS0
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

368408:TPEN RS03065
gene id: 368408:TPEN_RS03065
uniprot id: A1RXR2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

368408:TPEN RS08865
gene id: 368408:TPEN_RS08865
uniprot id: A1S103
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS01615
gene id: 368408:TPEN_RS01615
uniprot id: A1RWZ7
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

368408:TPEN RS08510
gene id: 368408:TPEN_RS08510
uniprot id: A1S0T2
names: Similarity
messages: Belongs to the HypE family.

368408:TPEN RS00925
gene id: 368408:TPEN_RS00925
uniprot id: A1RWL6
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS05905
gene id: 368408:TPEN_RS05905
uniprot id: A1RZB6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

368408:TPEN RS07905
gene id: 368408:TPEN_RS07905
uniprot id: A1S0G1
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS07410
gene id: 368408:TPEN_RS07410
uniprot id: A1S063
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS00950
gene id: 368408:TPEN_RS00950
uniprot id: A1RWM1
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS05685
gene id: 368408:TPEN_RS05685
uniprot id: A1RZ74
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

368408:TPEN RS07295
gene id: 368408:TPEN_RS07295
uniprot id: A1S042
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

368408:TPEN RS09295
gene id: 368408:TPEN_RS09295
uniprot id: A1S189
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

368408:TPEN RS06440
gene id: 368408:TPEN_RS06440
uniprot id: A1RZM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

368408:TPEN RS02100
gene id: 368408:TPEN_RS02100
uniprot id: A1RX88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

368408:TPEN RS09325
gene id: 368408:TPEN_RS09325
uniprot id: A1S195
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

368408:TPEN RS08560
gene id: 368408:TPEN_RS08560
uniprot id: A1S0U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

368408:TPEN RS00355
gene id: 368408:TPEN_RS00355
uniprot id: A1RWA0
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

368408:TPEN RS07945
gene id: 368408:TPEN_RS07945
uniprot id: A1S0G9
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS04490
gene id: 368408:TPEN_RS04490
uniprot id: A1RYJ3
names: Similarity
messages: Belongs to the PdaD family.

368408:TPEN RS01180
gene id: 368408:TPEN_RS01180
uniprot id: A1RWR7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

368408:TPEN RS01370
gene id: 368408:TPEN_RS01370
uniprot id: A1RWV4
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

368408:TPEN RS08130
gene id: 368408:TPEN_RS08130
uniprot id: A1S0K6
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

368408:TPEN RS03180
gene id: 368408:TPEN_RS03180
uniprot id: A1RXT4
names: Similarity
messages: Belongs to the RutC family.

368408:TPEN RS06390
gene id: 368408:TPEN_RS06390
uniprot id: A1RZL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

368408:TPEN RS02305
gene id: 368408:TPEN_RS02305
uniprot id: A1RXC6
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

368408:TPEN RS04625
gene id: 368408:TPEN_RS04625
uniprot id: A1RYL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

368408:TPEN RS00595
gene id: 368408:TPEN_RS00595
uniprot id: A1RWF0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

368408:TPEN RS03905
gene id: 368408:TPEN_RS03905
uniprot id: A1RY76
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.
messages: The N-terminal domain is an archaea-specific tRNA-editing domain that hydrolyzes incorrectly charged L-seryl-tRNA(Thr). Catalysis of tRNA editing is performed by the charged tRNA itself.

368408:TPEN RS06220
gene id: 368408:TPEN_RS06220
uniprot id: A1RZH9
names: Similarity
messages: Belongs to the monomethylamine methyltransferase family.

368408:TPEN RS05585
gene id: 368408:TPEN_RS05585
uniprot id: A1RZ54
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS01960
gene id: 368408:TPEN_RS01960
uniprot id: A1RX64
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

368408:TPEN RS01880
gene id: 368408:TPEN_RS01880
uniprot id: A1RX48
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

368408:TPEN RS03195
gene id: 368408:TPEN_RS03195
uniprot id: A1RXT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

368408:TPEN RS04715
gene id: 368408:TPEN_RS04715
uniprot id: A1RYN7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

368408:TPEN RS07705
gene id: 368408:TPEN_RS07705
uniprot id: A1S0C2
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS01560
gene id: 368408:TPEN_RS01560
uniprot id: A1RWY6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

368408:TPEN RS09080
gene id: 368408:TPEN_RS09080
uniprot id: A1S146
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

368408:TPEN RS04615
gene id: 368408:TPEN_RS04615
uniprot id: A1RYL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

368408:TPEN RS00010
gene id: 368408:TPEN_RS00010
uniprot id: A1RW32
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

368408:TPEN RS02115
gene id: 368408:TPEN_RS02115
uniprot id: A1RX91
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS07185
gene id: 368408:TPEN_RS07185
uniprot id: A1S020
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS03590
gene id: 368408:TPEN_RS03590
uniprot id: A1RY16
names: Similarity
messages: Belongs to the UPF0200 family.

368408:TPEN RS01855
gene id: 368408:TPEN_RS01855
uniprot id: A1RX43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

368408:TPEN RS01770
gene id: 368408:TPEN_RS01770
uniprot id: A1RX27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

368408:TPEN RS00875
gene id: 368408:TPEN_RS00875
uniprot id: A1RWK6
names: Similarity
messages: Belongs to the AOR/FOR family.

368408:TPEN RS03095
gene id: 368408:TPEN_RS03095
uniprot id: A1RXR7
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

368408:TPEN RS01170
gene id: 368408:TPEN_RS01170
uniprot id: A1RWR5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

368408:TPEN RS09320
gene id: 368408:TPEN_RS09320
uniprot id: A1S194
names: Similarity
messages: Belongs to the UDPGP type 2 family.

368408:TPEN RS02090
gene id: 368408:TPEN_RS02090
uniprot id: A1RX86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

368408:TPEN RS08325
gene id: 368408:TPEN_RS08325
uniprot id: A1S0P5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YjjX NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

368408:TPEN RS09235
gene id: 368408:TPEN_RS09235
uniprot id: A1S177
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

368408:TPEN RS01145
gene id: 368408:TPEN_RS01145
uniprot id: A1RWR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

368408:TPEN RS04695
gene id: 368408:TPEN_RS04695
uniprot id: A1RYN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

368408:TPEN RS02120
gene id: 368408:TPEN_RS02120
uniprot id: A1RX92
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

368408:TPEN RS06030
gene id: 368408:TPEN_RS06030
uniprot id: A1RZE1
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS07305
gene id: 368408:TPEN_RS07305
uniprot id: A1S044
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.

368408:TPEN RS02155
gene id: 368408:TPEN_RS02155
uniprot id: A1RXA0
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

368408:TPEN RS06645
gene id: 368408:TPEN_RS06645
uniprot id: A1RZR5
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

368408:TPEN RS04440
gene id: 368408:TPEN_RS04440
uniprot id: A1RYI3
names: Similarity
messages: Belongs to the RuvB family.

368408:TPEN RS04330
gene id: 368408:TPEN_RS04330
uniprot id: A1RYG1
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS01480
gene id: 368408:TPEN_RS01480
uniprot id: A1RWX1
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

368408:TPEN RS01200
gene id: 368408:TPEN_RS01200
uniprot id: A1RWS1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

368408:TPEN RS04530
gene id: 368408:TPEN_RS04530
uniprot id: A1RYK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

368408:TPEN RS05680
gene id: 368408:TPEN_RS05680
uniprot id: A1RZ73
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS07460
gene id: 368408:TPEN_RS07460
uniprot id: A1S073
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

368408:TPEN RS01330
gene id: 368408:TPEN_RS01330
uniprot id: A1RWU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

368408:TPEN RS03250
gene id: 368408:TPEN_RS03250
uniprot id: A1RXU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

368408:TPEN RS05240
gene id: 368408:TPEN_RS05240
uniprot id: A1RYY6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

368408:TPEN RS00645
gene id: 368408:TPEN_RS00645
uniprot id: A1RWG0
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

368408:TPEN RS03670
gene id: 368408:TPEN_RS03670
uniprot id: A1RY31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

368408:TPEN RS04380
gene id: 368408:TPEN_RS04380
uniprot id: A1RYH1
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS00700
gene id: 368408:TPEN_RS00700
uniprot id: A1RWH1
names: Similarity
messages: Belongs to the Nth/MutY family.

368408:TPEN RS01285
gene id: 368408:TPEN_RS01285
uniprot id: A1RWT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

368408:TPEN RS07530
gene id: 368408:TPEN_RS07530
uniprot id: A1S087
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

368408:TPEN RS04020
gene id: 368408:TPEN_RS04020
uniprot id: A1RY99
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS01245
gene id: 368408:TPEN_RS01245
uniprot id: A1RWT0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

368408:TPEN RS07615
gene id: 368408:TPEN_RS07615
uniprot id: A1S0A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

368408:TPEN RS03830
gene id: 368408:TPEN_RS03830
uniprot id: A1RY61
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

368408:TPEN RS04255
gene id: 368408:TPEN_RS04255
uniprot id: A1RYE5
names: Similarity
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.

368408:TPEN RS07160
gene id: 368408:TPEN_RS07160
uniprot id: A1S015
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS07900
gene id: 368408:TPEN_RS07900
uniprot id: A1S0G0
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

368408:TPEN RS08125
gene id: 368408:TPEN_RS08125
uniprot id: A1S0K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

368408:TPEN RS08315
gene id: 368408:TPEN_RS08315
uniprot id: A1S0P3
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

368408:TPEN RS01110
gene id: 368408:TPEN_RS01110
uniprot id: A1RWQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

368408:TPEN RS03380
gene id: 368408:TPEN_RS03380
uniprot id: A1RXX5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

368408:TPEN RS08355
gene id: 368408:TPEN_RS08355
uniprot id: A1S0Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

368408:TPEN RS05720
gene id: 368408:TPEN_RS05720
uniprot id: A1RZ81
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit.

368408:TPEN RS01810
gene id: 368408:TPEN_RS01810
uniprot id: A1RX34
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

368408:TPEN RS07470
gene id: 368408:TPEN_RS07470
uniprot id: A1S075
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

368408:TPEN RS02390
gene id: 368408:TPEN_RS02390
uniprot id: A1RXE1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

368408:TPEN RS05015
gene id: 368408:TPEN_RS05015
uniprot id: A1RYU3
names: Similarity
messages: Belongs to the DtxR/MntR family.

368408:TPEN RS09210
gene id: 368408:TPEN_RS09210
uniprot id: A1S172
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

368408:TPEN RS09145
gene id: 368408:TPEN_RS09145
uniprot id: A1S159
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

368408:TPEN RS05510
gene id: 368408:TPEN_RS05510
uniprot id: A1RZ39
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

368408:TPEN RS01340
gene id: 368408:TPEN_RS01340
uniprot id: A1RWU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

368408:TPEN RS07435
gene id: 368408:TPEN_RS07435
uniprot id: A1S068
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

368408:TPEN RS02185
gene id: 368408:TPEN_RS02185
uniprot id: A1RXA5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

368408:TPEN RS08140
gene id: 368408:TPEN_RS08140
uniprot id: A1S0K8
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS00620
gene id: 368408:TPEN_RS00620
uniprot id: A1RWF5
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

368408:TPEN RS07550
gene id: 368408:TPEN_RS07550
uniprot id: A1S091
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS02550
gene id: 368408:TPEN_RS02550
uniprot id: A1RXG9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

368408:TPEN RS05370
gene id: 368408:TPEN_RS05370
uniprot id: A1RZ12
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

368408:TPEN RS02775
gene id: 368408:TPEN_RS02775
uniprot id: A1RXL1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

368408:TPEN RS04315
gene id: 368408:TPEN_RS04315
uniprot id: A1RYF8
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

368408:TPEN RS01540
gene id: 368408:TPEN_RS01540
uniprot id: A1RWY2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

368408:TPEN RS01440
gene id: 368408:TPEN_RS01440
uniprot id: A1RWW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

368408:TPEN RS02175
gene id: 368408:TPEN_RS02175
uniprot id: A1RXA3
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

368408:TPEN RS01995
gene id: 368408:TPEN_RS01995
uniprot id: A1RX71
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

368408:TPEN RS02695
gene id: 368408:TPEN_RS02695
uniprot id: A1RXJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

368408:TPEN RS01100
gene id: 368408:TPEN_RS01100
uniprot id: A1RWQ1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

368408:TPEN RS02460
gene id: 368408:TPEN_RS02460
uniprot id: A1RXF3
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

368408:TPEN RS05455
gene id: 368408:TPEN_RS05455
uniprot id: A1RZ29
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

368408:TPEN RS08565
gene id: 368408:TPEN_RS08565
uniprot id: A1S0U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

368408:TPEN RS02080
gene id: 368408:TPEN_RS02080
uniprot id: A1RX84
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

368408:TPEN RS01590
gene id: 368408:TPEN_RS01590
uniprot id: A1RWZ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

368408:TPEN RS00145
gene id: 368408:TPEN_RS00145
uniprot id: A1RW58
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

368408:TPEN RS01290
gene id: 368408:TPEN_RS01290
uniprot id: A1RWT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

368408:TPEN RS05030
gene id: 368408:TPEN_RS05030
uniprot id: A1RYU6
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS06830
gene id: 368408:TPEN_RS06830
uniprot id: A1RZU9
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS02975
gene id: 368408:TPEN_RS02975
uniprot id: A1RXQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

368408:TPEN RS04585
gene id: 368408:TPEN_RS04585
uniprot id: A1RYL2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

368408:TPEN RS02225
gene id: 368408:TPEN_RS02225
uniprot id: A1RXB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

368408:TPEN RS02705
gene id: 368408:TPEN_RS02705
uniprot id: A1RXJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

368408:TPEN RS03805
gene id: 368408:TPEN_RS03805
uniprot id: A1RY56
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

368408:TPEN RS07540
gene id: 368408:TPEN_RS07540
uniprot id: A1S089
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

368408:TPEN RS08245
gene id: 368408:TPEN_RS08245
uniprot id: A1S0M9
names: Similarity
messages: Belongs to the HupF/HypC family.

368408:TPEN RS03285
gene id: 368408:TPEN_RS03285
uniprot id: A1RXV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group II subfamily.
messages: Cytoplasm
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

368408:TPEN RS02470
gene id: 368408:TPEN_RS02470
uniprot id: A1RXF5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

368408:TPEN RS08420
gene id: 368408:TPEN_RS08420
uniprot id: A1S0R4
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

368408:TPEN RS09260
gene id: 368408:TPEN_RS09260
uniprot id: A1S182
names: Similarity
messages: Belongs to the AOR/FOR family.

368408:TPEN RS07440
gene id: 368408:TPEN_RS07440
uniprot id: A1S069
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

368408:TPEN RS06060
gene id: 368408:TPEN_RS06060
uniprot id: A1RZE7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

368408:TPEN RS03675
gene id: 368408:TPEN_RS03675
uniprot id: A1RY32
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

368408:TPEN RS01935
gene id: 368408:TPEN_RS01935
uniprot id: A1RX59
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

368408:TPEN RS09550
gene id: 368408:TPEN_RS09550
uniprot id: A1S1E0
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

368408:TPEN RS01140
gene id: 368408:TPEN_RS01140
uniprot id: A1RWQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

368408:TPEN RS02385
gene id: 368408:TPEN_RS02385
uniprot id: A1RXE0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

368408:TPEN RS07455
gene id: 368408:TPEN_RS07455
uniprot id: A1S072
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

368408:TPEN RS01875
gene id: 368408:TPEN_RS01875
uniprot id: A1RX47
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

368408:TPEN RS01890
gene id: 368408:TPEN_RS01890
uniprot id: A1RX50
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

368408:TPEN RS01505
gene id: 368408:TPEN_RS01505
uniprot id: A1RWX6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

368408:TPEN RS05855
gene id: 368408:TPEN_RS05855
uniprot id: A1RZA7
names: Similarity
messages: Belongs to the glutamate synthase family.

368408:TPEN RS07610
gene id: 368408:TPEN_RS07610
uniprot id: A1S0A3
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS07515
gene id: 368408:TPEN_RS07515
uniprot id: A1S084
names: Similarity
messages: Belongs to the trimethylamine methyltransferase family.

368408:TPEN RS03510
gene id: 368408:TPEN_RS03510
uniprot id: A1RY01
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

368408:TPEN RS04220
gene id: 368408:TPEN_RS04220
uniprot id: A1RYD8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

368408:TPEN RS08250
gene id: 368408:TPEN_RS08250
uniprot id: A1S0N0
names: Similarity
messages: Belongs to the HypD family.

368408:TPEN RS03665
gene id: 368408:TPEN_RS03665
uniprot id: A1RY30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

368408:TPEN RS03170
gene id: 368408:TPEN_RS03170
uniprot id: A1RXT3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

368408:TPEN RS00110
gene id: 368408:TPEN_RS00110
uniprot id: A1RW51
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

368408:TPEN RS01360
gene id: 368408:TPEN_RS01360
uniprot id: A1RWV2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

368408:TPEN RS09055
gene id: 368408:TPEN_RS09055
uniprot id: A1S141
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS05525
gene id: 368408:TPEN_RS05525
uniprot id: A1RZ42
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS01135
gene id: 368408:TPEN_RS01135
uniprot id: A1RWQ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

368408:TPEN RS01655
gene id: 368408:TPEN_RS01655
uniprot id: A1RX04
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

368408:TPEN RS03920
gene id: 368408:TPEN_RS03920
uniprot id: A1RY79
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

368408:TPEN RS02450
gene id: 368408:TPEN_RS02450
uniprot id: A1RXF1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

368408:TPEN RS06175
gene id: 368408:TPEN_RS06175
uniprot id: A1RZH1
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS08215
gene id: 368408:TPEN_RS08215
uniprot id: A1S0M3
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

368408:TPEN RS03540
gene id: 368408:TPEN_RS03540
uniprot id: A1RY07
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

368408:TPEN RS00210
gene id: 368408:TPEN_RS00210
uniprot id: A1RW71
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

368408:TPEN RS07075
gene id: 368408:TPEN_RS07075
uniprot id: A1RZZ8
names: Similarity
messages: Belongs to the archaeal ATPase family.

368408:TPEN RS00625
gene id: 368408:TPEN_RS00625
uniprot id: A1RWF6
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

368408:TPEN RS04700
gene id: 368408:TPEN_RS04700
uniprot id: A1RYN4
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS03935
gene id: 368408:TPEN_RS03935
uniprot id: A1RY82
names: Similarity
messages: Belongs to the glutaredoxin family.

368408:TPEN RS01395
gene id: 368408:TPEN_RS01395
uniprot id: A1RWV7
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

368408:TPEN RS05970
gene id: 368408:TPEN_RS05970
uniprot id: A1RZC9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

368408:TPEN RS00930
gene id: 368408:TPEN_RS00930
uniprot id: A1RWL7
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS02395
gene id: 368408:TPEN_RS02395
uniprot id: A1RXE2
names: Similarity
messages: Belongs to the UPF0147 family.

368408:TPEN RS03895
gene id: 368408:TPEN_RS03895
uniprot id: A1RY74
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

368408:TPEN RS08885
gene id: 368408:TPEN_RS08885
uniprot id: A1S107
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

368408:TPEN RS01730
gene id: 368408:TPEN_RS01730
uniprot id: A1RX19
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

368408:TPEN RS07855
gene id: 368408:TPEN_RS07855
uniprot id: A1S0F1
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS07745
gene id: 368408:TPEN_RS07745
uniprot id: A1S0D0
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS03025
gene id: 368408:TPEN_RS03025
uniprot id: A1RXQ8
names: Similarity
messages: Belongs to the SDO1/SBDS family.

368408:TPEN RS05380
gene id: 368408:TPEN_RS05380
uniprot id: A1RZ14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

368408:TPEN RS03410
gene id: 368408:TPEN_RS03410
uniprot id: A1RXY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

368408:TPEN RS06425
gene id: 368408:TPEN_RS06425
uniprot id: A1RZM1
names: Similarity
messages: Belongs to the HepT RNase toxin family.

368408:TPEN RS02960
gene id: 368408:TPEN_RS02960
uniprot id: A1RXP9
names: Subunit
messages: Heterodimer composed of an alpha and a beta subunit.

368408:TPEN RS08990
gene id: 368408:TPEN_RS08990
uniprot id: A1S128
names: Similarity
messages: Belongs to the UPF0251 family.

368408:TPEN RS01815
gene id: 368408:TPEN_RS01815
uniprot id: A1RX35
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

368408:TPEN RS01420
gene id: 368408:TPEN_RS01420
uniprot id: A1RWW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

368408:TPEN RS00140
gene id: 368408:TPEN_RS00140
uniprot id: A1RW57
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

368408:TPEN RS00735
gene id: 368408:TPEN_RS00735
uniprot id: A1RWH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

368408:TPEN RS03185
gene id: 368408:TPEN_RS03185
uniprot id: A1RXT5
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

368408:TPEN RS01215
gene id: 368408:TPEN_RS01215
uniprot id: A1RWS4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

368408:TPEN RS05460
gene id: 368408:TPEN_RS05460
uniprot id: A1RZ30
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

368408:TPEN RS05350
gene id: 368408:TPEN_RS05350
uniprot id: A1RZ08
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS05570
gene id: 368408:TPEN_RS05570
uniprot id: A1RZ51
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS06040
gene id: 368408:TPEN_RS06040
uniprot id: A1RZE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

368408:TPEN RS01930
gene id: 368408:TPEN_RS01930
uniprot id: A1RX58
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

368408:TPEN RS06145
gene id: 368408:TPEN_RS06145
uniprot id: A1RZG5
names: Similarity
messages: Belongs to the MscS (TC 1.A.23) family.

368408:TPEN RS09205
gene id: 368408:TPEN_RS09205
uniprot id: A1S171
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS01335
gene id: 368408:TPEN_RS01335
uniprot id: A1RWU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

368408:TPEN RS01130
gene id: 368408:TPEN_RS01130
uniprot id: A1RWQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

368408:TPEN RS04805
gene id: 368408:TPEN_RS04805
uniprot id: A1RYQ3
names: Similarity
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.

368408:TPEN RS01160
gene id: 368408:TPEN_RS01160
uniprot id: A1RWR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

368408:TPEN RS04690
gene id: 368408:TPEN_RS04690
uniprot id: A1RYN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

368408:TPEN RS03545
gene id: 368408:TPEN_RS03545
uniprot id: A1RY08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA cytidine acetyltransferase family. TmcA subfamily.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm

368408:TPEN RS07935
gene id: 368408:TPEN_RS07935
uniprot id: A1S0G7
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

368408:TPEN RS01230
gene id: 368408:TPEN_RS01230
uniprot id: A1RWS7
names: Similarity
messages: Belongs to the UPF0215 family.

368408:TPEN RS04280
gene id: 368408:TPEN_RS04280
uniprot id: A1RYF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

368408:TPEN RS01365
gene id: 368408:TPEN_RS01365
uniprot id: A1RWV3
names: Similarity
messages: Belongs to the MEMO1 family.

368408:TPEN RS05795
gene id: 368408:TPEN_RS05795
uniprot id: A1RZ95
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

368408:TPEN RS00260
gene id: 368408:TPEN_RS00260
uniprot id: A1RW81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

368408:TPEN RS06140
gene id: 368408:TPEN_RS06140
uniprot id: A1RZG4
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS03525
gene id: 368408:TPEN_RS03525
uniprot id: A1RY04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

368408:TPEN RS08495
gene id: 368408:TPEN_RS08495
uniprot id: A1S0S9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

368408:TPEN RS02545
gene id: 368408:TPEN_RS02545
uniprot id: A1RXG8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

368408:TPEN RS02905
gene id: 368408:TPEN_RS02905
uniprot id: A1RXN7
names: Function
names: Similarity
messages: Belongs to the FAU-1 family.
messages: Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.

368408:TPEN RS04180
gene id: 368408:TPEN_RS04180
uniprot id: A1RYD1
names: Similarity
messages: Belongs to the phosphohexose mutase family.

368408:TPEN RS01400
gene id: 368408:TPEN_RS01400
uniprot id: A1RWV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

368408:TPEN RS04770
gene id: 368408:TPEN_RS04770
uniprot id: A1RYP8
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

368408:TPEN RS08505
gene id: 368408:TPEN_RS08505
uniprot id: A1S0T1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Cytoplasm
messages: Homotetramer.

368408:TPEN RS04520
gene id: 368408:TPEN_RS04520
uniprot id: A1RYJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

368408:TPEN RS02825
gene id: 368408:TPEN_RS02825
uniprot id: A1RXM1
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

368408:TPEN RS01225
gene id: 368408:TPEN_RS01225
uniprot id: A1RWS6
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

368408:TPEN RS02570
gene id: 368408:TPEN_RS02570
uniprot id: A1RXH3
names: Subcellular Location Annotation
messages: Nucleus

368408:TPEN RS05605
gene id: 368408:TPEN_RS05605
uniprot id: A1RZ58
names: Similarity
messages: Belongs to the glutamine synthetase family.

368408:TPEN RS07995
gene id: 368408:TPEN_RS07995
uniprot id: A1S0H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.
messages: Membrane

368408:TPEN RS05910
gene id: 368408:TPEN_RS05910
uniprot id: A1RZB7
names: Subcellular Location Annotation
messages: Membrane

368408:TPEN RS04660
gene id: 368408:TPEN_RS04660
uniprot id: A1RYM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

368408:TPEN RS02610
gene id: 368408:TPEN_RS02610
uniprot id: A1RXI1
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

368408:TPEN RS04065
gene id: 368408:TPEN_RS04065
uniprot id: A1RYA8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

368408:TPEN RS00025
gene id: 368408:TPEN_RS00025
uniprot id: A1RW35
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

368408:TPEN RS03325
gene id: 368408:TPEN_RS03325
uniprot id: A1RXW4
names: Similarity
messages: Belongs to the eIF-2-alpha family.

368408:TPEN RS02915
gene id: 368408:TPEN_RS02915
uniprot id: A1RXN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

368408:TPEN RS03595
gene id: 368408:TPEN_RS03595
uniprot id: A1RY17
names: Similarity
messages: Belongs to the UPF0201 family.

368408:TPEN RS04390
gene id: 368408:TPEN_RS04390
uniprot id: A1RYH3
names: Similarity
messages: Belongs to the UPF0111 family.

368408:TPEN RS05420
gene id: 368408:TPEN_RS05420
uniprot id: A1RZ22
names: Similarity
messages: Belongs to the acylphosphatase family.

368408:TPEN RS00525
gene id: 368408:TPEN_RS00525
uniprot id: A1RWD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

368408:TPEN RS00410
gene id: 368408:TPEN_RS00410
uniprot id: A1RWB1
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

368408:TPEN RS05365
gene id: 368408:TPEN_RS05365
uniprot id: A1RZ11
names: Subcellular Location Annotation
messages: Nucleus