367110:NCU04118
gene id: 367110:NCU04118
uniprot id: Q1K7N1
names: Similarity
messages: Belongs to the aspartokinase family.

367110:NCU03094
gene id: 367110:NCU03094
uniprot id: Q7SCZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL54 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU06482
gene id: 367110:NCU06482
uniprot id: Q7RYJ2
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

367110:NCU00212
gene id: 367110:NCU00212
uniprot id: P04914
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

367110:NCU06262
gene id: 367110:NCU06262
uniprot id: Q7SB51
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.
messages: Highly sensible to fluoride. Growth is inhibited at a 200-fold lower fluoride concentration than in the wild-type.

367110:NCU01935
gene id: 367110:NCU01935
uniprot id: Q7SDN8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

367110:NCU02223
gene id: 367110:NCU02223
uniprot id: Q7S4H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

367110:NCU01458
gene id: 367110:NCU01458
uniprot id: A3RNI0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

367110:NCU09652
gene id: 367110:NCU09652
uniprot id: Q7S271
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

367110:NCU09380
gene id: 367110:NCU09380
uniprot id: Q7SCW4
names: Function
names: Subcellular Location Annotation
messages: RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.
messages: nucleolus

367110:NCU00952
gene id: 367110:NCU00952
uniprot id: Q7SGH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL53 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU05292
gene id: 367110:NCU05292
uniprot id: Q7S906
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDI1 family.
messages: Binds ubiquitin and polyubiquitinated proteins.
messages: Cytoplasm
messages: Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control.

367110:NCU08804
gene id: 367110:NCU08804
uniprot id: Q7S8T0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be involved in iron transport and iron homeostasis.
messages: Membrane

367110:NCU02679
gene id: 367110:NCU02679
uniprot id: Q7SH50
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

367110:NCU03479
gene id: 367110:NCU03479
uniprot id: Q8WZS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.
messages: Nucleus

367110:NCU10853
gene id: 367110:NCU10853
uniprot id: V5IM78
uniprot id: V5INQ0
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.

367110:NCU08869
gene id: 367110:NCU08869
uniprot id: Q7S795
names: Similarity
messages: Belongs to the FHIP family.

367110:NCU06660
gene id: 367110:NCU06660
uniprot id: Q871V2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0057 (PMP3) family.
messages: Cell membrane
messages: Plays a role in the regulation of membrane potential. Could mediate a proton leak (By similarity).

367110:NCU05604
gene id: 367110:NCU05604
uniprot id: Q7S6W1
names: Similarity
messages: Belongs to the multicopper oxidase family.

367110:NCU04736
gene id: 367110:NCU04736
uniprot id: Q1K6I5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Membrane

367110:NCU01167
gene id: 367110:NCU01167
uniprot id: Q1K864
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU08947
gene id: 367110:NCU08947
uniprot id: P48503
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (cob), cytochrome c1 (cyt-1) and Rieske protein (fes-1), 2 core protein subunits pep and ucr-1, and 5 low-molecular weight protein subunits qcr6, qcr7, qcr8, qcr9 and probably NCU16844/qcr10 (PubMed:226365, PubMed:6273583, PubMed:18251112, PubMed:6302289). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplexes SCI(1)III(2), SCIII(2)IV(1) and SCIII(2)IV(2) as well as higher order I(x)III(y)IV(z) megacomplexes) (PubMed:17873079, PubMed:19239619).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Mitochondrion inner membrane

367110:NCU07010
gene id: 367110:NCU07010
uniprot id: V5INX0
uniprot id: V5IPD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytoskeleton

367110:NCU08927
gene id: 367110:NCU08927
uniprot id: Q1K6J1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
messages: Delta(4)-fatty-acid desaturase which introduces a double bond at the 4-position in the long-chain base (LCB) of ceramides.
messages: Membrane

367110:NCU04225
gene id: 367110:NCU04225
uniprot id: Q1K6U7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL58 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU08280
gene id: 367110:NCU08280
uniprot id: Q7S8B3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the squalene monooxygenase family.
messages: Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

367110:NCU04080
gene id: 367110:NCU04080
uniprot id: Q7RWM9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. SWF1 subfamily.
messages: Endoplasmic reticulum membrane
messages: Palmitoyltransferase that targets several endosomal SNAREs. Palmitoylates the SNAREs at cysteine residues close to the cytoplasmic end of their transmembrane domain. May have a role in the cellular quality control of transmembrane domain-containing proteins (By similarity).
messages: The DHHC domain is required for palmitoyltransferase activity.

367110:NCU00294
gene id: 367110:NCU00294
uniprot id: Q7RZS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Component of the large ribosomal subunit (LSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins (Probable). uL1 forms part of the L1 stalk (By similarity).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL1 forms part of the L1 stalk, a mobile element that plays a role in evacuating the exit-site tRNA.
messages: Cytoplasm

367110:NCU07330
gene id: 367110:NCU07330
uniprot id: Q7SA33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

367110:NCU04462
gene id: 367110:NCU04462
uniprot id: Q7RYE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.
messages: Endoplasmic reticulum membrane

367110:NCU04165
gene id: 367110:NCU04165
uniprot id: Q1K6P5
names: Similarity
messages: Belongs to the LTV1 family.

367110:NCU04371
gene id: 367110:NCU04371
uniprot id: Q6M981
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
messages: Cytoplasm
messages: Inhibited by both FK506 and rapamycin.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

367110:NCU09955
gene id: 367110:NCU09955
uniprot id: Q7S1K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
messages: Membrane

367110:NCU10762
gene id: 367110:NCU10762
uniprot id: A7UWK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU00821
gene id: 367110:NCU00821
uniprot id: Q7SEB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU02733
gene id: 367110:NCU02733
uniprot id: Q7SGB6
uniprot id: V5IPK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Golgi apparatus membrane
messages: Golgi membrane protein involved in vesicular trafficking.
messages: Membrane

367110:NCU02237
gene id: 367110:NCU02237
uniprot id: Q7S442
names: Function
names: Similarity
messages: Belongs to the Clp1 family. NOL9/GRC3 subfamily.
messages: Polynucleotide 5'-kinase involved in rRNA processing.

367110:NCU04054
gene id: 367110:NCU04054
uniprot id: P05220
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

367110:NCU02532
gene id: 367110:NCU02532
uniprot id: V5IP93
uniprot id: V5IRG0
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.

367110:NCU06544
gene id: 367110:NCU06544
uniprot id: P87253
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

367110:NCU07775
gene id: 367110:NCU07775
uniprot id: Q1K687
names: Similarity
messages: Belongs to the TAF11 family.

367110:NCU04363
gene id: 367110:NCU04363
uniprot id: Q7RWR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF alpha subunit family.
messages: Nucleus

367110:NCU05029
gene id: 367110:NCU05029
uniprot id: Q7RX59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
messages: Homodimer.
messages: Mitochondrion inner membrane
messages: Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by egt-3 and other mitochondrial proteins (By similarity). Hydrolyzes ATP (By similarity). Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (By similarity).

367110:NCU01614
gene id: 367110:NCU01614
uniprot id: Q9P5Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity).

367110:NCU01827
gene id: 367110:NCU01827
uniprot id: Q1K580
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL27 family.

367110:NCU06123
gene id: 367110:NCU06123
uniprot id: Q7S5G5
names: Similarity
messages: Belongs to the XFP family.

367110:NCU07930
gene id: 367110:NCU07930
uniprot id: V5INR2
names: Cofactor
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.

367110:NCU03148
gene id: 367110:NCU03148
uniprot id: Q7SDU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAC-beta family.
messages: Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. Npc-2/egd1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.
messages: Cytoplasm
messages: Nucleus
messages: Part of the nascent polypeptide-associated complex (NAC), consisting of npc-1/egd2 and npc-2/egd1. NAC associates with ribosomes via npc-2/egd1 (By similarity).

367110:NCU04368
gene id: 367110:NCU04368
uniprot id: Q7RWR2
names: Similarity
messages: Belongs to the GST superfamily.

367110:NCU08605
gene id: 367110:NCU08605
uniprot id: Q7SDF7
names: Subunit
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

367110:NCU01731
gene id: 367110:NCU01731
uniprot id: Q1K5S5
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the velvet family. VeA subfamily.
messages: Component of the heterotrimeric velvet complex composed of lae-1, ve-1 and vel-2; Ve-1 acting as a bridging protein between lae-1 and vel-2 (By similarity).
messages: Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination (PubMed:17631397). The velvet complex hat acts as a global regulator for secondary metabolite gene expression (By similarity).
messages: Constitutively expressed during asexual and sexual development and induced by red light, indicating a light-dependent regulation (PubMed:17631397).
messages: Cytoplasm
messages: Nucleus
messages: Results in increased conidiation associated with stunted aerial hyphae (PubMed:17631397).
messages: The C-terminal PEST domain is a region rich in proline, glutamic acid, serine and threonine residues that is required for the light-dependent regulation of development and secondary metabolism (By similarity).

367110:NCU16599
gene id: 367110:NCU16599
uniprot id: V5IQC3
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU08438
gene id: 367110:NCU08438
uniprot id: F5HHZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBT5 family.
messages: Membrane

367110:NCU06264
gene id: 367110:NCU06264
uniprot id: Q7SB49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Involved in ds DNA break repair. Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining.
messages: Nucleus

367110:NCU05421
gene id: 367110:NCU05421
uniprot id: V5IQZ2
names: Function
names: Similarity
messages: Belongs to the LplA family.
messages: Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.

367110:NCU05843
gene id: 367110:NCU05843
uniprot id: Q7S5K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

367110:NCU02386
gene id: 367110:NCU02386
uniprot id: Q7S4P8
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU05343
gene id: 367110:NCU05343
uniprot id: V5IP92
uniprot id: V5IPT4
names: Subcellular Location Annotation
messages: Cytoplasm

367110:NCU11182
gene id: 367110:NCU11182
uniprot id: U9W399
uniprot id: U9W8K6
names: Similarity
messages: Belongs to the alkB family.

367110:NCU00476
gene id: 367110:NCU00476
uniprot id: Q7RXW9
names: Similarity
messages: Belongs to the SDO1/SBDS family.

367110:NCU03108
gene id: 367110:NCU03108
uniprot id: Q7SFY6
names: Similarity
messages: Belongs to the peptidase M28 family. M28B subfamily.

367110:NCU04043
gene id: 367110:NCU04043
uniprot id: Q7RZH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
messages: Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
messages: cytoskeleton

367110:NCU00685
gene id: 367110:NCU00685
uniprot id: V5IQ40
uniprot id: V5IR38
uniprot id: V5IRD9
names: Similarity
messages: Belongs to the protein kinase superfamily.

367110:NCU08502
gene id: 367110:NCU08502
uniprot id: V5INQ2
uniprot id: V5IQ82
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

367110:NCU02905
gene id: 367110:NCU02905
uniprot id: Q7SHJ9
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

367110:NCU01904
gene id: 367110:NCU01904
uniprot id: Q7SHA2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU03226
gene id: 367110:NCU03226
uniprot id: Q7SGU3
names: Subcellular Location Annotation
messages: Cytoplasm

367110:NCU00954
gene id: 367110:NCU00954
uniprot id: Q7SGG8
names: Function
names: Similarity
messages: Belongs to the AB hydrolase superfamily.
messages: Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit (By similarity).

367110:NCU01966
gene id: 367110:NCU01966
uniprot id: V5IQ48
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

367110:NCU01951
gene id: 367110:NCU01951
uniprot id: Q1K906
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

367110:NCU03233
gene id: 367110:NCU03233
uniprot id: Q7SGT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (cob), cytochrome c1 (cyt-1) and Rieske protein (fes-1), 2 core protein subunits pep and ucr-1, and 5 low-molecular weight protein subunits qcr6, qcr7, qcr8, qcr9 and probably NCU16844/qcr10 (PubMed:226365, PubMed:6273583, PubMed:6302289). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplexes SCI(1)III(2), SCIII(2)IV(1) and SCIII(2)IV(2) as well as higher order I(x)III(y)IV(z) megacomplexes) (PubMed:17873079, PubMed:19239619).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Mitochondrion inner membrane

367110:NCU04553
gene id: 367110:NCU04553
uniprot id: P14799
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Cytoplasm
messages: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus
messages: Ubiquitin is encoded by 3 different genes. Crp-79 is synthesized as a polyprotein with one copy of ubiquitin fused to ribosomal protein eL40. Crp-6/ubi-3 is a polyprotein with one copy of ubiquitin fused to ribosomal protein eS31. Ubi is a polyprotein containing 4 exact head to tail repeats of ubiquitin.

367110:NCU04459
gene id: 367110:NCU04459
uniprot id: Q7RYE8
names: Function
names: Subcellular Location Annotation
messages: Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation.
messages: Nucleus

367110:NCU07493
gene id: 367110:NCU07493
uniprot id: Q7SG49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS46 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Mitochondrion

367110:NCU00193
gene id: 367110:NCU00193
uniprot id: Q7RX94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU00682
gene id: 367110:NCU00682
uniprot id: Q7SHX1
names: Similarity
messages: Belongs to the protein kinase superfamily.

367110:NCU01055
gene id: 367110:NCU01055
uniprot id: Q7S816
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

367110:NCU01267
gene id: 367110:NCU01267
uniprot id: Q7S7C5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autopalmitoylated.
messages: Belongs to the DHHC palmitoyltransferase family. PFA3 subfamily.
messages: Palmitoyltransferase specific for vac8. Palmitoylates vac8 at one or more of its N-terminal cysteine residues, which is required for its proper membrane localization (By similarity).
messages: The DHHC domain is required for palmitoyltransferase activity.
messages: Vacuole membrane

367110:NCU00258
gene id: 367110:NCU00258
uniprot id: O43105
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS7 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Cytoplasm

367110:NCU04207
gene id: 367110:NCU04207
uniprot id: Q1K7D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU01343
gene id: 367110:NCU01343
uniprot id: Q1K7T3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDHAF2 family.
messages: Interacts with the flavoprotein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.

367110:NCU04495
gene id: 367110:NCU04495
uniprot id: Q7RYB2
names: Similarity
messages: Belongs to the cyclin family. Cyclin C subfamily.

367110:NCU10467
gene id: 367110:NCU10467
uniprot id: A7UWD6
names: Similarity
messages: Belongs to the activator 1 small subunits family.

367110:NCU10776
gene id: 367110:NCU10776
uniprot id: A7UW97
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. Three molecules of dnr-8/fen1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Mitochondrion
messages: Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

367110:NCU05151
gene id: 367110:NCU05151
uniprot id: Q1K591
names: Similarity
messages: Belongs to the XFP family.

367110:NCU06026
gene id: 367110:NCU06026
uniprot id: P11636
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Expression is induced in the presence of quinic acid (PubMed:6458044). The quinic acid (qa) gene cluster is subject to two levels of gene control: a primary system which responds to the presence of quinic acid via the qa-1S repressor protein that blocks the qa-1F activator, and a secondary system which represses transcription of qa genes in the presence of a preferred carbon source such as glucose (PubMed:6458044, PubMed:12477937, PubMed:17597928, PubMed:19236936).
messages: Impairs growth on quinic acid as a sole carbon source and leads to very low inducible levels of qa-2 and qa-3 enzyme activities.
messages: MFS-type transporter; part of the qa gene cluster that mediates the catabolism of quinic acid (QA) and as such, allows the use of QA as a sole carbon source (PubMed:2525625, PubMed:6458044). Involved in the upatke of QA (PubMed:1533844). The qa cluster encodes 3 inducible enymes (qa-2, qa-3 and qa-4) catalyzing the first three reactions in the catabolism of quinic acid to protocatechuic acid (also known as 3,4-Dihydroxybenzoic acid) (Probable).
messages: Membrane

367110:NCU03317
gene id: 367110:NCU03317
uniprot id: Q7SEM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol.
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU02555
gene id: 367110:NCU02555
uniprot id: Q7SHR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP4 subfamily.
messages: Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair (By similarity).
messages: Component of the NuA4 histone acetyltransferase complex, of the INO80 chromatin remodeling complex, and of the SWR1 chromatin remodeling complex.
messages: Nucleus

367110:NCU06041
gene id: 367110:NCU06041
uniprot id: Q7RV09
names: PTM
names: Similarity
messages: Belongs to the sulfatase family.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

367110:NCU08030
gene id: 367110:NCU08030
uniprot id: Q7SAL1
names: Function
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

367110:NCU05350
gene id: 367110:NCU05350
uniprot id: Q7SC74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU06712
gene id: 367110:NCU06712
uniprot id: Q1K6X9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

367110:NCU07693
gene id: 367110:NCU07693
uniprot id: Q7S9L2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CLASP family.
messages: Interacts with microtubules.
messages: Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation (By similarity).
messages: Nucleus
messages: cytoskeleton
messages: spindle

367110:NCU08339
gene id: 367110:NCU08339
uniprot id: Q7SGS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

367110:NCU01202
gene id: 367110:NCU01202
uniprot id: Q1K840
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BIG1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU08888
gene id: 367110:NCU08888
uniprot id: Q1K6A2
names: Similarity
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Tetramer of two alpha and two beta subunits.

367110:NCU05104
gene id: 367110:NCU05104
uniprot id: Q1K5N1
names: Similarity
messages: Belongs to the glycosyl hydrolase 7 (cellulase C) family.

367110:NCU04859
gene id: 367110:NCU04859
uniprot id: Q7S386
names: Caution
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

367110:NCU07259
gene id: 367110:NCU07259
uniprot id: Q7S956
names: Similarity
messages: Belongs to the peptidase C13 family.

367110:NCU02268
gene id: 367110:NCU02268
uniprot id: Q7S598
names: Similarity
messages: Belongs to the COG3 family.

367110:NCU09648
gene id: 367110:NCU09648
uniprot id: Q7S275
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

367110:NCU07545
gene id: 367110:NCU07545
uniprot id: Q7S303
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SARAF family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU04639
gene id: 367110:NCU04639
uniprot id: Q1K6H5
names: Subcellular Location Annotation
messages: Membrane

367110:NCU07130
gene id: 367110:NCU07130
uniprot id: Q7S6C2
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

367110:NCU08127
gene id: 367110:NCU08127
uniprot id: Q7S4K4
names: Similarity
messages: Belongs to the glycosyl hydrolase 76 family.

367110:NCU06438
gene id: 367110:NCU06438
uniprot id: Q7RYX9
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

367110:NCU04289
gene id: 367110:NCU04289
uniprot id: Q1K782
names: Similarity
messages: Belongs to the cytidylyltransferase family.

367110:NCU09400
gene id: 367110:NCU09400
uniprot id: Q7S292
names: Similarity
messages: Belongs to the paxB family.

367110:NCU07624
gene id: 367110:NCU07624
uniprot id: Q7SB01
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.

367110:NCU07821
gene id: 367110:NCU07821
uniprot id: Q7SBE3
names: Similarity
messages: Belongs to the FMO family.

367110:NCU00111
gene id: 367110:NCU00111
uniprot id: Q7RYL7
names: Similarity
messages: Belongs to the FUN14 family.

367110:NCU06997
gene id: 367110:NCU06997
uniprot id: Q7SAF3
names: Similarity
messages: Belongs to the GILT family.

367110:NCU11311
gene id: 367110:NCU11311
uniprot id: Q9Y8C0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer; composed of 3 copies of tim8 and 3 copies of tim13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of tim22 and tim54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The tim8-tim13 complex is non essential and only mediates the import of few proteins, while the predominant tim9-tim10 70 kDa complex is crucial and mediates the import of much more proteins.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of tim8 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

367110:NCU05933
gene id: 367110:NCU05933
uniprot id: Q7S0P0
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

367110:NCU09913
gene id: 367110:NCU09913
uniprot id: Q7S143
names: Similarity
messages: Belongs to the major royal jelly protein family.

367110:NCU05071
gene id: 367110:NCU05071
uniprot id: Q7RWL3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M35 family.
messages: Binds 1 zinc ion per subunit.
messages: Secreted
messages: Secreted metalloproteinase that allows assimilation of proteinaceous substrates. Shows high activities on basic nuclear substrates such as histone and protamine.

367110:NCU01850
gene id: 367110:NCU01850
uniprot id: Q7SD18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-16 family.
messages: Peroxisome membrane

367110:NCU06941
gene id: 367110:NCU06941
uniprot id: Q7S0H5
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

367110:NCU05753
gene id: 367110:NCU05753
uniprot id: Q7S4R9
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.

367110:NCU07375
gene id: 367110:NCU07375
uniprot id: Q7S2I7
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

367110:NCU02091
gene id: 367110:NCU02091
uniprot id: Q7SCL9
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

367110:NCU00108
gene id: 367110:NCU00108
uniprot id: Q7RYM0
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

367110:NCU02161
gene id: 367110:NCU02161
uniprot id: Q7SEQ6
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU02389
gene id: 367110:NCU02389
uniprot id: Q7S4P5
names: Similarity
messages: Belongs to the UPF0696 family.

367110:NCU04412
gene id: 367110:NCU04412
uniprot id: Q7RZ62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU09896
gene id: 367110:NCU09896
uniprot id: Q7S203
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

367110:NCU02630
gene id: 367110:NCU02630
uniprot id: Q7SDI0
names: Similarity
messages: Belongs to the ClpA/ClpB family.

367110:NCU06751
gene id: 367110:NCU06751
uniprot id: Q1K8T5
names: Similarity
messages: Belongs to the PITHD1 family.

367110:NCU00775
gene id: 367110:NCU00775
uniprot id: Q7SFV4
names: Similarity
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Octamer of two non-identical subunits IDH1 and IDH2.

367110:NCU04292
gene id: 367110:NCU04292
uniprot id: Q1K779
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

367110:NCU06826
gene id: 367110:NCU06826
uniprot id: F5HH93
names: Similarity
messages: Belongs to the EME1/MMS4 family.

367110:NCU00154
gene id: 367110:NCU00154
uniprot id: U9W346
uniprot id: U9W8D5
names: Function
names: Similarity
messages: Belongs to the peptidase M24B family.
messages: Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.

367110:NCU09567
gene id: 367110:NCU09567
uniprot id: Q7S427
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

367110:NCU00352
gene id: 367110:NCU00352
uniprot id: Q7RZL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

367110:NCU08766
gene id: 367110:NCU08766
uniprot id: Q872W1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy (By similarity).
messages: Belongs to the ATG17 family.
messages: Cytoplasm
messages: Preautophagosomal structure membrane

367110:NCU02353
gene id: 367110:NCU02353
uniprot id: V5IML0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.

367110:NCU03893
gene id: 367110:NCU03893
uniprot id: Q7RZD4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU03102
gene id: 367110:NCU03102
uniprot id: Q7SFZ2
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

367110:NCU00642
gene id: 367110:NCU00642
uniprot id: Q7SI10
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

367110:NCU04470
gene id: 367110:NCU04470
uniprot id: Q7RYD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HDDC2 family.
messages: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
messages: Homodimer.

367110:NCU00675
gene id: 367110:NCU00675
uniprot id: Q7SHX8
names: Similarity
messages: Belongs to the EFR3 family.

367110:NCU10376
gene id: 367110:NCU10376
uniprot id: V5IQX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC6 family.
messages: Nucleus

367110:NCU01634
gene id: 367110:NCU01634
uniprot id: P04914
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

367110:NCU02407
gene id: 367110:NCU02407
uniprot id: Q7S477
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

367110:NCU03030
gene id: 367110:NCU03030
uniprot id: P12063
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Has both an aminoacyl-tRNA synthetase activity and is involved in the splicing of group I introns. It acts in intron splicing by stabilizing the catalytically active structure of the intron.
messages: Mitochondrion matrix

367110:NCU03277
gene id: 367110:NCU03277
uniprot id: Q7SDX8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.
messages: Membrane
messages: Peroxisome membrane

367110:NCU05259
gene id: 367110:NCU05259
uniprot id: Q7S8C6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Expected to bind 2 Fe(2+) ions per subunit.
messages: Membrane
messages: Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.

367110:NCU03561
gene id: 367110:NCU03561
uniprot id: Q1K4V9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

367110:NCU01116
gene id: 367110:NCU01116
uniprot id: Q1K769
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

367110:NCU06908
gene id: 367110:NCU06908
uniprot id: Q7S3E5
names: Function
names: Similarity
messages: Belongs to the MUB1/samB family.
messages: Involved in determination of the onset of polarized growth and morphogenesis. Plays a role in the regulation of branching in hyphae and spore formation.

367110:NCU07970
gene id: 367110:NCU07970
uniprot id: Q7S915
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

367110:NCU07076
gene id: 367110:NCU07076
uniprot id: Q7S6E8
names: Similarity
messages: Belongs to the glycosyl hydrolase 81 family.

367110:NCU01302
gene id: 367110:NCU01302
uniprot id: Q1K7W3
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

367110:NCU03114
gene id: 367110:NCU03114
uniprot id: Q7SFY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SSU72 phosphatase family.
messages: Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Ssu-72 is required for 3'-end formation of snoRNAs (By similarity).
messages: Component of the cleavage and polyadenylation factor (CPF) complex.
messages: Nucleus
messages: Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (rpb-1).

367110:NCU08378
gene id: 367110:NCU08378
uniprot id: V5IQ34
names: Similarity
messages: Belongs to the peptidase C19 family.

367110:NCU09377
gene id: 367110:NCU09377
uniprot id: V5IPN6
uniprot id: V5IRJ1
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

367110:NCU00628
gene id: 367110:NCU00628
uniprot id: Q7SI24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

367110:NCU07884
gene id: 367110:NCU07884
uniprot id: Q7SB09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

367110:NCU09172
gene id: 367110:NCU09172
uniprot id: Q7S343
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03231
gene id: 367110:NCU03231
uniprot id: Q7SGT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

367110:NCU05453
gene id: 367110:NCU05453
uniprot id: Q1K8R1
names: Subcellular Location Annotation
messages: Membrane

367110:NCU07904
gene id: 367110:NCU07904
uniprot id: Q7SA13
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU01936
gene id: 367110:NCU01936
uniprot id: Q7SDN7
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU00315
gene id: 367110:NCU00315
uniprot id: Q7RZP9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

367110:NCU09721
gene id: 367110:NCU09721
uniprot id: Q7S2Q5
names: Function
names: Similarity
messages: Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
messages: Belongs to the adaptor complexes large subunit family.

367110:NCU05973
gene id: 367110:NCU05973
uniprot id: V5IM98
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.

367110:NCU00177
gene id: 367110:NCU00177
uniprot id: Q7RXB0
names: Function
names: Similarity
messages: Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.
messages: In the C-terminal section; belongs to the AIR synthase family.
messages: In the N-terminal section; belongs to the GARS family.

367110:NCU03752
gene id: 367110:NCU03752
uniprot id: Q1K7C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU01829
gene id: 367110:NCU01829
uniprot id: F5HE32
names: Similarity
messages: Belongs to the TTC36 family.

367110:NCU03822
gene id: 367110:NCU03822
uniprot id: Q1K7F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESS2 family.
messages: Nucleus

367110:NCU08359
gene id: 367110:NCU08359
uniprot id: Q7SGQ6
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

367110:NCU03218
gene id: 367110:NCU03218
uniprot id: Q7SGV1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane
messages: Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells. Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network, for cytoplasm to vacuole transport (Cvt), mitophagy, and pexophagy (By similarity).
messages: The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization to the perivacuolar punctate structures.

367110:NCU05964
gene id: 367110:NCU05964
uniprot id: Q7S1V7
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU09039
gene id: 367110:NCU09039
uniprot id: Q7S2T6
names: Subcellular Location Annotation
messages: Membrane

367110:NCU08976
gene id: 367110:NCU08976
uniprot id: Q7S2Z3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

367110:NCU06832
gene id: 367110:NCU06832
uniprot id: V5INE7
uniprot id: V5IR03
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: cytoskeleton

367110:NCU07962
gene id: 367110:NCU07962
uniprot id: Q7S923
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBT5 family.
messages: Membrane

367110:NCU07063
gene id: 367110:NCU07063
uniprot id: Q7S6G0
names: Similarity
messages: Belongs to the peptidase A1 family.

367110:NCU07655
gene id: 367110:NCU07655
uniprot id: Q7SAX7
names: Subcellular Location Annotation
messages: nuclear pore complex

367110:NCU17017
gene id: 367110:NCU17017
uniprot id: V5IN95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Mitochondrion inner membrane

367110:NCU02338
gene id: 367110:NCU02338
uniprot id: Q7S4S7
names: Similarity
messages: Belongs to the Necrosis inducing protein (NPP1) family.

367110:NCU09111
gene id: 367110:NCU09111
uniprot id: Q7RV86
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.

367110:NCU02536
gene id: 367110:NCU02536
uniprot id: Q7SHS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiH/COQ6 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
messages: Mitochondrion inner membrane

367110:NCU06960
gene id: 367110:NCU06960
uniprot id: Q7SAI9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

367110:NCU08411
gene id: 367110:NCU08411
uniprot id: V5IPP8
uniprot id: V5IQA2
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

367110:NCU07171
gene id: 367110:NCU07171
uniprot id: Q1K5W6
names: Similarity
messages: Belongs to the actin family.

367110:NCU07998
gene id: 367110:NCU07998
uniprot id: Q7SAP2
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU16769
gene id: 367110:NCU16769
uniprot id: V5IN64
names: Similarity
messages: Belongs to the TYW1 family.

367110:NCU00809
gene id: 367110:NCU00809
uniprot id: Q7SEC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU03058
gene id: 367110:NCU03058
uniprot id: Q7SCK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 16 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

367110:NCU09778
gene id: 367110:NCU09778
uniprot id: Q7RVB3
names: Similarity
messages: Belongs to the protein kinase superfamily.

367110:NCU01524
gene id: 367110:NCU01524
uniprot id: Q1K5J6
names: Similarity
messages: Belongs to the BRX1 family.

367110:NCU05518
gene id: 367110:NCU05518
uniprot id: Q7S6S1
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

367110:NCU01433
gene id: 367110:NCU01433
uniprot id: Q1K4R9
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.

367110:NCU08301
gene id: 367110:NCU08301
uniprot id: Q7RVY0
names: Similarity
messages: Belongs to the PPP phosphatase family.

367110:NCU06453
gene id: 367110:NCU06453
uniprot id: Q7RYW5
names: Similarity
messages: Belongs to the VPS72/YL1 family.

367110:NCU02468
gene id: 367110:NCU02468
uniprot id: Q7SG95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingosine N-acyltransferase family.
messages: Membrane

367110:NCU10352
gene id: 367110:NCU10352
uniprot id: A7UXE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity).
messages: Component of the heptameric LSM1-LSM7 complex, which consists of snr-1/lsm1, snr-2/lsm2, snr-3/lsm3, snr-4/lsm4, snr-5/lsm5, snr-6/lsm6 and snr-7/lsm7. Component of the heptameric LSM2-LSM8 complex, which consists of snr-2/lsm2, snr-3/lsm3, snr-4/lsm4, snr-5/lsm5, snr-6/lsm6, snr-7/lsm7 and snr-8/lsm8. The LSm subunits form a seven-membered ring structure with a doughnut shape (By similarity).
messages: Cytoplasm
messages: Nucleus

367110:NCU03777
gene id: 367110:NCU03777
uniprot id: Q1K7A4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enoyl-CoA hydratase/isomerase family. Mitochondrion-specific ribosomal protein mS47 subfamily.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (Probable). mS47 has enzymatic activity in vitro, and is able to catalyze the specific hydrolysis of 3-hydroxyisobutyryl-CoA (HIBYL-CoA). However, because the turnover rate of mS47 is only a fraction of that of the homologous mammalian enzyme, the physiological function of this activity remains unclear (By similarity).
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins. mS47 forms a protuberance of the N.crassa mitoribosome and retains a solvent-exposed cavity liekly capable of accommodating a substrate, in accordance with it being an active enzyme as well as an integral constituent of the mitoribosome.
messages: Mitochondrion

367110:NCU04135
gene id: 367110:NCU04135
uniprot id: Q1K7L9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

367110:NCU00434
gene id: 367110:NCU00434
uniprot id: Q7RXS5
names: Similarity
messages: Belongs to the PP2C family.

367110:NCU05967
gene id: 367110:NCU05967
uniprot id: Q7S1V4
names: Similarity
messages: Belongs to the cytochrome P450 family.

367110:NCU07721
gene id: 367110:NCU07721
uniprot id: Q7S8R8
names: Function
names: Similarity
messages: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the proteasome subunit S2 family.

367110:NCU09170
gene id: 367110:NCU09170
uniprot id: Q7S345
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

367110:NCU07200
gene id: 367110:NCU07200
uniprot id: Q871C5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M43B family.
messages: Secreted
messages: Secreted metalloproteinase that allows assimilation of proteinaceous substrates.

367110:NCU02757
gene id: 367110:NCU02757
uniprot id: Q7SCX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU02531
gene id: 367110:NCU02531
uniprot id: Q7SHT2
names: Similarity
messages: Belongs to the TEL2 family.

367110:NCU01528
gene id: 367110:NCU01528
uniprot id: P54118
names: Developmental Stage
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Clock-regulated. The peak of GAPDH activity lags several hours behind the peak in mRNA accumulation in the late night.
messages: Cytoplasm
messages: Homotetramer.

367110:NCU03559
gene id: 367110:NCU03559
uniprot id: O60044
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (cob), cytochrome c1 (cyt-1) and Rieske protein (fes-1), 2 core protein subunits pep and ucr-1, and 5 low-molecular weight protein subunits qcr6, qcr7, qcr8, qcr9 and probably NCU16844/qcr10 (PubMed:226365, PubMed:6273583, PubMed:18251112, PubMed:6302289). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplexes SCI(1)III(2), SCIII(2)IV(1) and SCIII(2)IV(2) as well as higher order I(x)III(y)IV(z) megacomplexes) (PubMed:17873079, PubMed:19239619).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Does not seem to have protease activity as it lacks the zinc-binding site.
messages: Mitochondrion inner membrane
messages: Mutants display reduced growth, are female sterile and lack active complex III.

367110:NCU06694
gene id: 367110:NCU06694
uniprot id: Q1K743
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

367110:NCU16422
gene id: 367110:NCU16422
uniprot id: V5IRA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST5 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

367110:NCU02181
gene id: 367110:NCU02181
uniprot id: Q7SE03
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

367110:NCU07401
gene id: 367110:NCU07401
uniprot id: V5IPU3
uniprot id: V5IR85
names: Subcellular Location Annotation
messages: Membrane
messages: Vacuole membrane

367110:NCU00371
gene id: 367110:NCU00371
uniprot id: U9W395
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03468
gene id: 367110:NCU03468
uniprot id: Q1K517
names: Subcellular Location Annotation
messages: Membrane

367110:NCU04370
gene id: 367110:NCU04370
uniprot id: Q7RWR0
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

367110:NCU07380
gene id: 367110:NCU07380
uniprot id: Q7S2I2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit D family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.

367110:NCU05180
gene id: 367110:NCU05180
uniprot id: V5IP47
uniprot id: V5IQS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

367110:NCU08328
gene id: 367110:NCU08328
uniprot id: Q7SA61
names: Similarity
messages: Belongs to the MT-A70-like family.

367110:NCU00311
gene id: 367110:NCU00311
uniprot id: Q7RZQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VTS1 family.
messages: Monomer. Binds to RNA.
messages: P-body
messages: RNA-binding protein involved in post-transcriptional regulation through transcript degradation.
messages: cytosol

367110:NCU06950
gene id: 367110:NCU06950
uniprot id: Q7S0X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFP11/STIP family.
messages: Nucleus

367110:NCU04274
gene id: 367110:NCU04274
uniprot id: Q9C224
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cut8/STS1 family.
messages: Binds the proteasome.
messages: Cytoplasm
messages: Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins (By similarity).
messages: Nucleus

367110:NCU03216
gene id: 367110:NCU03216
uniprot id: Q7SGV3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
messages: Mitochondrion matrix
messages: Monomer.

367110:NCU02434
gene id: 367110:NCU02434
uniprot id: Q7S3Y7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SQS1 family.
messages: Cytoplasm
messages: Nucleus

367110:NCU07483
gene id: 367110:NCU07483
uniprot id: Q1K928
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03971
gene id: 367110:NCU03971
uniprot id: Q7RZ98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
messages: In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.
messages: Nucleus
messages: Responsible for methylating the 5'-cap structure of mRNAs.

367110:NCU10910
gene id: 367110:NCU10910
uniprot id: A7UWM4
names: Subcellular Location Annotation
messages: Membrane

367110:NCU05616
gene id: 367110:NCU05616
uniprot id: Q7S5V0
names: Similarity
messages: Belongs to the methyltransferase superfamily. Arsenite methyltransferase family.

367110:NCU04002
gene id: 367110:NCU04002
uniprot id: Q870Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWC4 family.
messages: Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.
messages: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
messages: Nucleus

367110:NCU09811
gene id: 367110:NCU09811
uniprot id: Q7SDJ0
names: Subcellular Location Annotation
messages: Membrane

367110:NCU04138
gene id: 367110:NCU04138
uniprot id: Q1K7L7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Highly divergent.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins. bL31m bridges the mt-LSU central protuberance and the mt-SSU head.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU17108
gene id: 367110:NCU17108
uniprot id: V5ILJ7
uniprot id: V5IN92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 28 family.
messages: Endoplasmic reticulum
messages: Heterodimer with ALG14 to form a functional enzyme.
messages: Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.

367110:NCU01653
gene id: 367110:NCU01653
uniprot id: F5H950
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03406
gene id: 367110:NCU03406
uniprot id: V5IN01
uniprot id: V5IN90
names: Similarity
messages: Belongs to the SKP1 family.

367110:NCU03076
gene id: 367110:NCU03076
uniprot id: Q7SDT4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

367110:NCU05376
gene id: 367110:NCU05376
uniprot id: Q1K8I3
names: Similarity
messages: Belongs to the cytochrome P450 family.

367110:NCU09730
gene id: 367110:NCU09730
uniprot id: P48467
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.
messages: Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.
messages: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Its motor activity is directed toward the microtubule's plus end.
messages: cytoskeleton

367110:NCU01968
gene id: 367110:NCU01968
uniprot id: Q7SE92
names: Subcellular Location Annotation
messages: Membrane

367110:NCU04244
gene id: 367110:NCU04244
uniprot id: Q1K7J3
names: Similarity
messages: Belongs to the syntaxin family.

367110:NCU08973
gene id: 367110:NCU08973
uniprot id: Q7S2Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

367110:NCU06803
gene id: 367110:NCU06803
uniprot id: Q7SCH4
names: Similarity
messages: Belongs to the group II decarboxylase family.

367110:NCU08376
gene id: 367110:NCU08376
uniprot id: Q7SGN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RTC4 family.
messages: May be involved in a process influencing telomere capping.
messages: Nucleus

367110:NCU05046
gene id: 367110:NCU05046
uniprot id: Q1K506
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.

367110:NCU01418
gene id: 367110:NCU01418
uniprot id: Q01302
names: Induction
names: Similarity
messages: Belongs to the SED1 family.
messages: Expression levels may be influenced by circadian rhythms.

367110:NCU09095
gene id: 367110:NCU09095
uniprot id: Q7SFQ5
names: Similarity
messages: Belongs to the GAMAD family.

367110:NCU01553
gene id: 367110:NCU01553
uniprot id: Q1K4Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
messages: Mitochondrion inner membrane

367110:NCU06905
gene id: 367110:NCU06905
uniprot id: Q7S3E8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU06834
gene id: 367110:NCU06834
uniprot id: Q7SCH0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

367110:NCU08637
gene id: 367110:NCU08637
uniprot id: V5IQG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XLF subfamily.
messages: Nucleus

367110:NCU01285
gene id: 367110:NCU01285
uniprot id: Q1K6T5
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03023
gene id: 367110:NCU03023
uniprot id: Q7SGZ3
names: Similarity
messages: Belongs to the PheA/TfdB FAD monooxygenase family.

367110:NCU05313
gene id: 367110:NCU05313
uniprot id: Q7S8M1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIS1 family.
messages: Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity).
messages: Mitochondrion outer membrane
messages: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.

367110:NCU10497
gene id: 367110:NCU10497
uniprot id: A7UW38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

367110:NCU03156
gene id: 367110:NCU03156
uniprot id: Q07842
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA2 subunit family.
messages: Complex I is composed of about 40 different subunits.
messages: Mitochondrion inner membrane

367110:NCU08980
gene id: 367110:NCU08980
uniprot id: Q7S2Y9
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

367110:NCU03463
gene id: 367110:NCU03463
uniprot id: Q01290
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).
messages: Vacuole membrane

367110:NCU02073
gene id: 367110:NCU02073
uniprot id: Q7SEZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' RNA exonuclease that trims the 3' end of oligo(U) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate (By similarity). Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation (By similarity).
messages: Belongs to the 2H phosphoesterase superfamily. USB1 family.
messages: Nucleus

367110:NCU00913
gene id: 367110:NCU00913
uniprot id: Q7SCL1
uniprot id: V5IQE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGW family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.

367110:NCU06847
gene id: 367110:NCU06847
uniprot id: Q1K8K6
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06058
gene id: 367110:NCU06058
uniprot id: Q7S4Z2
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

367110:NCU01541
gene id: 367110:NCU01541
uniprot id: Q1K4Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GON7 family.
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
messages: Nucleus

367110:NCU06279
gene id: 367110:NCU06279
uniprot id: Q7SB62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit L family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

367110:NCU04376
gene id: 367110:NCU04376
uniprot id: V5INM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: nuclear pore complex

367110:NCU00567
gene id: 367110:NCU00567
uniprot id: P54898
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: In the C-terminal section; belongs to the NAGSA dehydrogenase family.
messages: In the N-terminal section; belongs to the acetylglutamate kinase family.
messages: Mitochondrion
messages: The protein precursor is cleaved into the two biologically active enzymes, the kinase and the reductase.

367110:NCU06035
gene id: 367110:NCU06035
uniprot id: Q7S4F0
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.

367110:NCU08627
gene id: 367110:NCU08627
uniprot id: O93798
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Cytoplasm

367110:NCU02376
gene id: 367110:NCU02376
uniprot id: Q7S4V1
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

367110:NCU09741
gene id: 367110:NCU09741
uniprot id: Q7SEI4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADPH--cytochrome P450 reductase family.
messages: Binds 1 FAD per monomer.
messages: Binds 1 FMN per monomer.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion outer membrane
messages: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.

367110:NCU03367
gene id: 367110:NCU03367
uniprot id: Q7RX23
names: Similarity
messages: Belongs to the TCF25 family.

367110:NCU02923
gene id: 367110:NCU02923
uniprot id: Q7SHI1
names: Caution
names: Function
names: Induction
names: Similarity
messages: A recent genetics report associated srdA and its cluster with the biosynthesis of furanocoumarin neurosporin A, a metabolite produced by N.crassa for chemoresistance against predation by arthropod fungivores (PubMed:28485098). However, based on the gene cluster organization and predicted gene functions, this cluster is unlikely to be involved in neurosporin A biosynthesis, but instead produces compounds similar to pyriculol (PubMed:30908040).
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Expression is up-regulated during sexual development (PubMed:19277664). Expression is also up-regulated during confrontation with the arthropod fungivore Drosophila melanogaster (PubMed:28485098).
messages: Short-chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of sordarial, a salicylic aldehyde structurally related to the phytotoxin pyriculol (PubMed:19277664, PubMed:28485098, PubMed:30908040). The most interesting aspect of this pathway is formation of an aromatic product from the highly reducing polyketide synthase srdA (PubMed:30908040). SrdA synthesizes a reduced polyketide chain from one molecule of acetyl-CoA and five molecules of malonyl-CoA (PubMed:30908040). The polyketide chain is then reductively released as an aldehyde (PubMed:30908040). The oxidoreductases srdC, srdD and srdE then oxidize one of the hydroxy groups to facilitate the intramolecular aldol condensation, followed by dehydration to yield a salicylic aldehyde (PubMed:30908040). This aldehyde can undergo facile reduction by endogenous reductases to yield the alcohol 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene (PubMed:30908040). The flavin-dependent srdI counteract against the propensity of the aldehydes to be reduced under physiological conditions and is responsible for reoxidizing 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene back to the salicylic aldehyde (PubMed:30908040). This salicylic aldehyde is then selectively epoxidized by the cupin-domain-containing oxidoreductase srdB to yield the epoxide, which can be hydrolyzed stereoselectively by the hydrolase srdG to give the final product sordarial (PubMed:30908040).

367110:NCU03359
gene id: 367110:NCU03359
uniprot id: Q1K519
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

367110:NCU05862
gene id: 367110:NCU05862
uniprot id: Q7S546
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03805
gene id: 367110:NCU03805
uniprot id: Q1K7G6
names: Similarity
messages: Belongs to the Cyclase 1 superfamily.

367110:NCU06625
gene id: 367110:NCU06625
uniprot id: Q7S9P1
names: Cofactor
names: Similarity
messages: Belongs to the cysteine dioxygenase family.
messages: Binds 1 Fe cation per subunit.

367110:NCU09013
gene id: 367110:NCU09013
uniprot id: Q7S0S0
names: Similarity
messages: Belongs to the UPF0047 family.

367110:NCU03415
gene id: 367110:NCU03415
uniprot id: Q1K5E9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

367110:NCU08044
gene id: 367110:NCU08044
uniprot id: Q7SAJ7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU03898
gene id: 367110:NCU03898
uniprot id: F5HID6
names: Similarity
messages: Belongs to the VPS25 family.

367110:NCU02004
gene id: 367110:NCU02004
uniprot id: Q7SFM8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

367110:NCU03343
gene id: 367110:NCU03343
uniprot id: Q873E4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS23 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Mitochondrion

367110:NCU01839
gene id: 367110:NCU01839
uniprot id: Q1K571
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

367110:NCU04670
gene id: 367110:NCU04670
uniprot id: V5ILW7
uniprot id: V5INQ3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

367110:NCU00436
gene id: 367110:NCU00436
uniprot id: Q7RXS3
names: Subcellular Location Annotation
messages: Mitochondrion outer membrane

367110:NCU03362
gene id: 367110:NCU03362
uniprot id: Q1K503
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane

367110:NCU04068
gene id: 367110:NCU04068
uniprot id: Q7RZF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU01485
gene id: 367110:NCU01485
uniprot id: Q7RXU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins. uL24m forms the wall of the exit tunnel.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU01328
gene id: 367110:NCU01328
uniprot id: F5HDV2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

367110:NCU03936
gene id: 367110:NCU03936
uniprot id: Q7RZC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Forms a complex with trm82.
messages: Nucleus

367110:NCU06552
gene id: 367110:NCU06552
uniprot id: Q9C1K8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
messages: Belongs to the ALG3 family.
messages: Endoplasmic reticulum membrane

367110:NCU00336
gene id: 367110:NCU00336
uniprot id: Q7RZM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HEATR1/UTP10 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity).
messages: nucleolus

367110:NCU09491
gene id: 367110:NCU09491
uniprot id: Q9HGR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate esterase 1 (CE1) family. Feruloyl esterase type B subfamily.
messages: Involved in degradation of plant cell walls. Hydrolyzes of the feruloyl-arabinose ester bond in arabinoxylans as well as the feruloyl-galactose and feruloyl-arabinose ester bonds in pectin (By similarity).
messages: Secreted

367110:NCU07520
gene id: 367110:NCU07520
uniprot id: Q7S1A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 61 family.
messages: Secreted

367110:NCU06281
gene id: 367110:NCU06281
uniprot id: Q7S836
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

367110:NCU07070
gene id: 367110:NCU07070
uniprot id: Q7S6F3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
messages: Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

367110:NCU01390
gene id: 367110:NCU01390
uniprot id: V5IN45
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC16 family. YJU2 subfamily.
messages: Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.
messages: Nucleus
messages: Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.

367110:NCU01171
gene id: 367110:NCU01171
uniprot id: Q1K862
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

367110:NCU00431
gene id: 367110:NCU00431
uniprot id: Q07335
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tom22 family.
messages: Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with tom20 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore. Docks tom20 and tom70 for interaction with the general TOM40 import pore (GIP) complex. May regulate the TOM machinery organization, stability and channel gating (By similarity).
messages: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 8 different proteins (tom5, tom6, tom7, tom20, tom22, tom37, tom40 and tom70). Interacts with tom20 and tom70 (By similarity).
messages: Its cytoplasmic domain associates with the cytoplasmic domains of tom20 and tom70. Its intermembrane space domain provides a trans binding site for presequences and the single membrane anchor is required for a stable interaction between the GIP complex proteins (By similarity).
messages: Mitochondrion outer membrane

367110:NCU02539
gene id: 367110:NCU02539
uniprot id: Q7SHS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Nucleus

367110:NCU04161
gene id: 367110:NCU04161
uniprot id: Q1K7K1
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03038
gene id: 367110:NCU03038
uniprot id: Q7SDH0
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

367110:NCU04595
gene id: 367110:NCU04595
uniprot id: A3RNH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
messages: telomere

367110:NCU00092
gene id: 367110:NCU00092
uniprot id: Q7RYN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EFG1 family.
messages: Involved in rRNA processing.
messages: nucleolus

367110:NCU08671
gene id: 367110:NCU08671
uniprot id: Q7S8W4
names: Similarity
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.

367110:NCU02741
gene id: 367110:NCU02741
uniprot id: Q1K929
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Nucleus
messages: Required both for recombination and for the repair of DNA damage caused by X-rays.

367110:NCU01229
gene id: 367110:NCU01229
uniprot id: Q1K825
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.

367110:NCU01675
gene id: 367110:NCU01675
uniprot id: Q1K5H7
names: Similarity
messages: Belongs to the RRP12 family.

367110:NCU01118
gene id: 367110:NCU01118
uniprot id: F5HGH3
names: Similarity
messages: Belongs to the SGT1 family.

367110:NCU01095
gene id: 367110:NCU01095
uniprot id: Q1K880
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03868
gene id: 367110:NCU03868
uniprot id: Q7RXI2
names: Subcellular Location Annotation
messages: Membrane

367110:NCU07675
gene id: 367110:NCU07675
uniprot id: Q7S9M6
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU06104
gene id: 367110:NCU06104
uniprot id: Q7S5I3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

367110:NCU09386
gene id: 367110:NCU09386
uniprot id: Q7SCV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Membrane

367110:NCU03060
gene id: 367110:NCU03060
uniprot id: V5IRK0
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU01816
gene id: 367110:NCU01816
uniprot id: P18407
names: Function
names: Induction
names: Similarity
messages: Belongs to the allantoicase family.
messages: Induced by uric acid. Repressed by nitrogen.
messages: Utilization of purines as secondary nitrogen sources, when primary sources are limiting.

367110:NCU04176
gene id: 367110:NCU04176
uniprot id: Q1K7E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ELP2 family.
messages: Cytoplasm
messages: Nucleus

367110:NCU00988
gene id: 367110:NCU00988
uniprot id: Q7SD36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU00024
gene id: 367110:NCU00024
uniprot id: U9W2Y6
names: Similarity
messages: Belongs to the yippee family.

367110:NCU09130
gene id: 367110:NCU09130
uniprot id: Q7S2L8
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU05813
gene id: 367110:NCU05813
uniprot id: Q7S5N0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins. uL22m forms the wall of the exit tunnel.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU06469
gene id: 367110:NCU06469
uniprot id: Q7RYV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU06340
gene id: 367110:NCU06340
uniprot id: Q7S9W6
names: Similarity
messages: Belongs to the TTC4 family.

367110:NCU01440
gene id: 367110:NCU01440
uniprot id: V5INB2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

367110:NCU03632
gene id: 367110:NCU03632
uniprot id: Q1K7Q2
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

367110:NCU01599
gene id: 367110:NCU01599
uniprot id: F5HHR7
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU00699
gene id: 367110:NCU00699
uniprot id: Q7SEU6
names: Subcellular Location Annotation
messages: Membrane

367110:NCU05908
gene id: 367110:NCU05908
uniprot id: Q7S0N2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M35 family.
messages: Binds 1 zinc ion per subunit.

367110:NCU01810
gene id: 367110:NCU01810
uniprot id: Q1K539
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

367110:NCU01024
gene id: 367110:NCU01024
uniprot id: F5HFS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic12 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

367110:NCU05588
gene id: 367110:NCU05588
uniprot id: Q7S6X5
names: Similarity
messages: Belongs to the DNA polymerase type-B-like family.

367110:NCU06211
gene id: 367110:NCU06211
uniprot id: U9WGI5
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.

367110:NCU05971
gene id: 367110:NCU05971
uniprot id: Q7S034
names: Similarity
messages: Belongs to the peptidase M24B family.

367110:NCU03907
gene id: 367110:NCU03907
uniprot id: Q1K600
names: Similarity
messages: Belongs to the TSR2 family.

367110:NCU06103
gene id: 367110:NCU06103
uniprot id: Q7S5I4
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

367110:NCU01564
gene id: 367110:NCU01564
uniprot id: Q1K4X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

367110:NCU00857
gene id: 367110:NCU00857
uniprot id: Q7SFH4
names: Subcellular Location Annotation
messages: Membrane

367110:NCU04779
gene id: 367110:NCU04779
uniprot id: Q7S630
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the ribosome.

367110:NCU01963
gene id: 367110:NCU01963
uniprot id: Q7SE95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC5 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: spindle

367110:NCU09001
gene id: 367110:NCU09001
uniprot id: Q7S2W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

367110:NCU03396
gene id: 367110:NCU03396
uniprot id: Q8X066
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: Required for pre-18S rRNA processing. May bind microtubules (By similarity).
messages: nucleolus

367110:NCU05261
gene id: 367110:NCU05261
uniprot id: Q7S8C4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: Homohexamer or homoheptamer. Organized in a ring with a central cavity.
messages: Mitochondrion matrix

367110:NCU09528
gene id: 367110:NCU09528
uniprot id: Q7S0I1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NOP16 family.
messages: Component of the pre-66S ribosomal particle.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

367110:NCU06576
gene id: 367110:NCU06576
uniprot id: Q7S8N7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proteasome inhibitor PI31 family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.

367110:NCU04245
gene id: 367110:NCU04245
uniprot id: P23231
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tom70 family.
messages: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 8 different proteins (tom5, tom6, tom7, tom20, tom22, tom37, tom40 and tom70).
messages: Mitochondrion outer membrane
messages: Receptor that accelerates the import of all mitochondrial precursor proteins. Seems to act in conjunction with mom19.

367110:NCU07299
gene id: 367110:NCU07299
uniprot id: V5IMK0
names: Similarity
messages: Belongs to the SF3A2 family.

367110:NCU01201
gene id: 367110:NCU01201
uniprot id: Q8X0S4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an activator of both rRNA/tRNA and protein methyltransferases. Together with methyltransferase mtq2, required for the methylation of eRF1 on 'Gln-182'. Together with methyltransferase trm11, required for the formation of 2-methylguanosine at position 10 (m2G10) in tRNA. Together with methyltransferase bud23, required for the formation of a 7-methylguanine in 18S rRNA. Involved in biogenesis of both 40S and 60S ribosomal subunits (By similarity).
messages: Belongs to the TRM112 family.
messages: Cytoplasm
messages: Heterodimer of mtq2-rmt-1/trm112, forming the eRF1 methyltransferase. Rmt-1/trm112 is necessary for the solubility and activity of the catalytic subunit mtq2. Interacts with trm11; required for full tRNA methyltransferase activity. Interacts with bud23; required for full rRNA methyltransferase activity (By similarity).
messages: Nucleus

367110:NCU05680
gene id: 367110:NCU05680
uniprot id: Q7SAY4
names: Similarity
messages: Belongs to the glycosyltransferase 15 family.

367110:NCU08292
gene id: 367110:NCU08292
uniprot id: Q7SA93
names: Subcellular Location Annotation
messages: Membrane

367110:NCU10185
gene id: 367110:NCU10185
uniprot id: F5HCY3
names: Function
names: Similarity
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.

367110:NCU06619
gene id: 367110:NCU06619
uniprot id: P38680
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Membrane
messages: Required for the transport of neutral aliphatic and aromatic amino acids via the N system.

367110:NCU06974
gene id: 367110:NCU06974
uniprot id: Q7SAH5
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

367110:NCU05941
gene id: 367110:NCU05941
uniprot id: V5IL37
uniprot id: V5INE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

367110:NCU09560
gene id: 367110:NCU09560
uniprot id: V5IKC6
uniprot id: V5IKH7
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

367110:NCU02655
gene id: 367110:NCU02655
uniprot id: Q7SH73
names: Subcellular Location Annotation
messages: Membrane

367110:NCU01741
gene id: 367110:NCU01741
uniprot id: Q1K5S1
names: Subcellular Location Annotation
messages: Membrane

367110:NCU01858
gene id: 367110:NCU01858
uniprot id: Q7SHE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSM3 family.
messages: Component of the fork protection complex (FPC) consisting of tof-1 and csm-3.
messages: Forms a fork protection complex (FPC) with tof-1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity).
messages: Nucleus

367110:NCU06846
gene id: 367110:NCU06846
uniprot id: Q7SC67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU09715
gene id: 367110:NCU09715
uniprot id: Q7S2R1
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.

367110:NCU03556
gene id: 367110:NCU03556
uniprot id: Q1K4W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

367110:NCU05168
gene id: 367110:NCU05168
uniprot id: Q7S8G5
names: Subcellular Location Annotation
messages: Membrane

367110:NCU09368
gene id: 367110:NCU09368
uniprot id: V5IPP1
uniprot id: V5IQK2
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06003
gene id: 367110:NCU06003
uniprot id: Q7RVR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transferase hexapeptide repeat family.
messages: Cytoplasm
messages: Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint (By similarity).

367110:NCU05683
gene id: 367110:NCU05683
uniprot id: Q7SBQ5
names: Similarity
messages: Belongs to the IlvD/Edd family.

367110:NCU10651
gene id: 367110:NCU10651
uniprot id: A7UWR7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

367110:NCU03753
gene id: 367110:NCU03753
uniprot id: P22151
names: Induction
messages: Grg-1 message levels were found to increase within minutes following the onset of glucose deprivation and rise 50 fold during the first 90 minutes of derepression.

367110:NCU07533
gene id: 367110:NCU07533
uniprot id: Q7S314
names: Similarity
messages: Belongs to the peptidase A1 family.

367110:NCU01958
gene id: 367110:NCU01958
uniprot id: P19392
uniprot id: V5IRD8
names: Caution
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MATALPHA1 family.
messages: Do not confuse Mt a-1 with MT A-1; these are two different proteins.
messages: Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional activator that induces the transcription of A-specific genes like mating factor ccg-4. Required for mating as an A-cell and for blocking of heterokaryon formation (vegetative incompatibility).
messages: Nucleus
messages: Only present in A-cells and in a/A diploid cells.

367110:NCU08133
gene id: 367110:NCU08133
uniprot id: Q7S4J8
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

367110:NCU04007
gene id: 367110:NCU04007
uniprot id: Q7RZJ5
names: Similarity
messages: Belongs to the nucleoporin Nup133 family.

367110:NCU01568
gene id: 367110:NCU01568
uniprot id: Q1K4X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

367110:NCU05761
gene id: 367110:NCU05761
uniprot id: Q7S4R2
names: Similarity
messages: Belongs to the ustYa family.

367110:NCU09707
gene id: 367110:NCU09707
uniprot id: Q7S2R9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit K family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

367110:NCU06118
gene id: 367110:NCU06118
uniprot id: Q7S5H0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP9 family.
messages: RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit (By similarity).
messages: nucleolus

367110:NCU04078
gene id: 367110:NCU04078
uniprot id: Q7RZE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.
messages: Mitochondrion

367110:NCU08563
gene id: 367110:NCU08563
uniprot id: Q01277
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the WD repeat MET30/SCONB/SCON-2 family.
messages: Component of the SCF(scon-2) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.
messages: Component of the SCF(scon-2) E3 ubiquitin ligase complex.
messages: Expressed only under low-sulfur conditions and expression is under the control of the cys-3 transcriptional activator.

367110:NCU02065
gene id: 367110:NCU02065
uniprot id: Q7SEZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMCO4 family.
messages: Membrane

367110:NCU02075
gene id: 367110:NCU02075
uniprot id: Q7RW06
names: Similarity
messages: Belongs to the heat shock protein 70 family.

367110:NCU07866
gene id: 367110:NCU07866
uniprot id: Q7SBU3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 40S cdc5-associated complex (or cwf complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome.
messages: Belongs to the CWF11 family.
messages: Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome.
messages: Nucleus

367110:NCU06057
gene id: 367110:NCU06057
uniprot id: Q7S4Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGM family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity (By similarity).

367110:NCU02043
gene id: 367110:NCU02043
uniprot id: Q7SF35
names: Similarity
messages: Belongs to the DeSI family.

367110:NCU06159
gene id: 367110:NCU06159
uniprot id: Q7S5C9
names: Subcellular Location Annotation
messages: Membrane

367110:NCU07353
gene id: 367110:NCU07353
uniprot id: Q7S163
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0499 family.
messages: Secreted
messages: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

367110:NCU01859
gene id: 367110:NCU01859
uniprot id: Q02854
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Complex I is composed of about 40 different subunits.
messages: Mitochondrion inner membrane
messages: The N-terminus is blocked.
messages: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

367110:NCU00274
gene id: 367110:NCU00274
uniprot id: Q7RZT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with DNA double-strand breaks.
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.
messages: Nucleus
messages: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity).
messages: telomere

367110:NCU09710
gene id: 367110:NCU09710
uniprot id: Q7S2R6
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

367110:NCU06372
gene id: 367110:NCU06372
uniprot id: V5IMH7
names: Similarity
messages: Belongs to the peptidase C12 family.

367110:NCU05780
gene id: 367110:NCU05780
uniprot id: Q7S5R3
names: Similarity
messages: Belongs to the GST superfamily.

367110:NCU00414
gene id: 367110:NCU00414
uniprot id: Q7RYP8
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

367110:NCU07931
gene id: 367110:NCU07931
uniprot id: Q7S9Y7
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

367110:NCU00292
gene id: 367110:NCU00292
uniprot id: Q7RZS2
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

367110:NCU07829
gene id: 367110:NCU07829
uniprot id: Q7SBD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Component of the large ribosomal subunit (LSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

367110:NCU07113
gene id: 367110:NCU07113
uniprot id: Q7S662
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

367110:NCU01601
gene id: 367110:NCU01601
uniprot id: Q1K562
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.
messages: Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.
messages: Cytoplasm
messages: P-body

367110:NCU08123
gene id: 367110:NCU08123
uniprot id: Q7S4K8
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU09892
gene id: 367110:NCU09892
uniprot id: Q7S207
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

367110:NCU02409
gene id: 367110:NCU02409
uniprot id: V5IKL0
uniprot id: V5IL05
names: Similarity
messages: Belongs to the VAC14 family.

367110:NCU00308
gene id: 367110:NCU00308
uniprot id: Q7RZQ6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

367110:NCU04022
gene id: 367110:NCU04022
uniprot id: Q1K608
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the REI1 family.
messages: Cytoplasm

367110:NCU05342
gene id: 367110:NCU05342
uniprot id: Q1K8M2
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

367110:NCU06213
gene id: 367110:NCU06213
uniprot id: U9W4M7
uniprot id: U9W851
names: Similarity
messages: Belongs to the PIAS family.

367110:NCU01006
gene id: 367110:NCU01006
uniprot id: O42637
names: Function
names: Subcellular Location Annotation
messages: Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Mitochondrion

367110:NCU06730
gene id: 367110:NCU06730
uniprot id: Q7S786
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

367110:NCU05990
gene id: 367110:NCU05990
uniprot id: V5IKT5
names: Subcellular Location Annotation
messages: Membrane

367110:NCU01142
gene id: 367110:NCU01142
uniprot id: V5IL87
uniprot id: V5ILI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA12 subunit family.
messages: Mitochondrion inner membrane

367110:NCU03981
gene id: 367110:NCU03981
uniprot id: V5ILK5
uniprot id: V5INA2
names: Subcellular Location Annotation
messages: Cytoplasm

367110:NCU03985
gene id: 367110:NCU03985
uniprot id: Q7RXJ7
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

367110:NCU06460
gene id: 367110:NCU06460
uniprot id: Q7RYV9
names: Similarity
messages: Belongs to the histidine acid phosphatase family.

367110:NCU03170
gene id: 367110:NCU03170
uniprot id: Q7SEW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MoaE family. MOCS2B subfamily.
messages: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
messages: Cytoplasm
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.

367110:NCU04728
gene id: 367110:NCU04728
uniprot id: Q7S6H6
names: Similarity
messages: Belongs to the hexokinase family.

367110:NCU07762
gene id: 367110:NCU07762
uniprot id: Q7S109
names: Subcellular Location Annotation
messages: Membrane

367110:NCU01379
gene id: 367110:NCU01379
uniprot id: Q7S7K6
names: Function
names: Subunit
messages: Associates with DNA double-strand breaks.
messages: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.

367110:NCU04449
gene id: 367110:NCU04449
uniprot id: Q7RWB7
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

367110:NCU04185
gene id: 367110:NCU04185
uniprot id: V5ILY7
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

367110:NCU02852
gene id: 367110:NCU02852
uniprot id: Q7SDQ4
names: Similarity
messages: Belongs to the cytochrome P450 family.

367110:NCU02696
gene id: 367110:NCU02696
uniprot id: Q7SH33
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (By similarity).
messages: Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.
messages: Nucleus
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

367110:NCU06732
gene id: 367110:NCU06732
uniprot id: Q7S785
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA(4) but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B(4) as the product compared to the homologous mammalian enzyme (in vitro).
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Nucleus

367110:NCU02982
gene id: 367110:NCU02982
uniprot id: Q1K946
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

367110:NCU04319
gene id: 367110:NCU04319
uniprot id: Q1K720
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: microtubule organizing center

367110:NCU05239
gene id: 367110:NCU05239
uniprot id: P30589
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chitin synthase family.
messages: Cell membrane
messages: Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.

367110:NCU02744
gene id: 367110:NCU02744
uniprot id: Q7SGA6
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

367110:NCU09238
gene id: 367110:NCU09238
uniprot id: Q7SCU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-K/MCM22 family.
messages: Nucleus
messages: centromere

367110:NCU16025
gene id: 367110:NCU16025
uniprot id: P37212
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
messages: Mitochondrion inner membrane

367110:NCU06879
gene id: 367110:NCU06879
uniprot id: Q7S3H4
names: Similarity
messages: Belongs to the UPF0235 family.

367110:NCU02374
gene id: 367110:NCU02374
uniprot id: Q7S4V3
names: Similarity
messages: Belongs to the proteasome subunit S11 family.

367110:NCU01192
gene id: 367110:NCU01192
uniprot id: Q1K845
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

367110:NCU16525
gene id: 367110:NCU16525
uniprot id: V5IQX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane

367110:NCU02031
gene id: 367110:NCU02031
uniprot id: Q1K919
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Membrane

367110:NCU01813
gene id: 367110:NCU01813
uniprot id: Q7RXF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU04393
gene id: 367110:NCU04393
uniprot id: Q7RZ80
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

367110:NCU04104
gene id: 367110:NCU04104
uniprot id: Q1K6V2
names: Similarity
messages: Belongs to the XPO2/CSE1 family.

367110:NCU06791
gene id: 367110:NCU06791
uniprot id: Q1K8Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-Q/OKP1 family.
messages: Nucleus

367110:NCU05587
gene id: 367110:NCU05587
uniprot id: Q7S6X6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP6 subfamily.
messages: Component of the SWR1 chromatin remodeling complex.
messages: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: cytoskeleton

367110:NCU08373
gene id: 367110:NCU08373
uniprot id: Q7SGP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family.
messages: Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-6', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5.
messages: Interacts with PEX1; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers.
messages: Peroxisome membrane
messages: cytosol

367110:NCU06859
gene id: 367110:NCU06859
uniprot id: Q7S0F6
names: Similarity
messages: Belongs to the RPAP1 family.

367110:NCU09566
gene id: 367110:NCU09566
uniprot id: Q7S428
names: Subcellular Location Annotation
messages: Membrane

367110:NCU09831
gene id: 367110:NCU09831
uniprot id: Q7S1R1
names: Subcellular Location Annotation
messages: Membrane

367110:NCU16398
gene id: 367110:NCU16398
uniprot id: V5IQ21
names: Subcellular Location Annotation
messages: Membrane

367110:NCU02974
gene id: 367110:NCU02974
uniprot id: Q7RUY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG8 family.
messages: Membrane

367110:NCU07787
gene id: 367110:NCU07787
uniprot id: Q1K679
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cerato-platanin family.
messages: Secreted

367110:NCU02515
gene id: 367110:NCU02515
uniprot id: Q7SHU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S9B family.
messages: Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
messages: Vacuole membrane

367110:NCU05390
gene id: 367110:NCU05390
uniprot id: Q1K8S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

367110:NCU02005
gene id: 367110:NCU02005
uniprot id: Q7SFM7
names: Similarity
messages: Belongs to the PAPS reductase family. CysH subfamily.

367110:NCU01692
gene id: 367110:NCU01692
uniprot id: P34085
names: Developmental Stage
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Abundant after 6-12 hours of growth. It is not significantly expressed after 24 hours, which is several hours after entering the stationary phase of growth.
messages: Belongs to the citrate synthase family.
messages: Citrate synthase is found in nearly all cells capable of oxidative metabolism.
messages: Mitochondrion matrix

367110:NCU16572
gene id: 367110:NCU16572
uniprot id: V5IQ77
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

367110:NCU06684
gene id: 367110:NCU06684
uniprot id: V5ILH6
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU01246
gene id: 367110:NCU01246
uniprot id: Q1K6K4
names: Similarity
messages: Belongs to the UreD family.

367110:NCU03095
gene id: 367110:NCU03095
uniprot id: Q7SCZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

367110:NCU00737
gene id: 367110:NCU00737
uniprot id: Q7SEE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PAM17 family.
messages: Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Component of the PAM complex, at least composed of hsp70-5/ssc1, grpe/mge1, tim44, un-4/pam16, pam17 and tim14/pam18.
messages: Mitochondrion inner membrane

367110:NCU04507
gene id: 367110:NCU04507
uniprot id: Q7RY56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II.
messages: Cytoplasm
messages: Nucleus
messages: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.

367110:NCU04818
gene id: 367110:NCU04818
uniprot id: Q7S6L7
names: Subcellular Location Annotation
messages: Membrane

367110:NCU02556
gene id: 367110:NCU02556
uniprot id: Q7SHQ9
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU02723
gene id: 367110:NCU02723
uniprot id: Q7SGC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.

367110:NCU02954
gene id: 367110:NCU02954
uniprot id: Q7SH15
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

367110:NCU01646
gene id: 367110:NCU01646
uniprot id: F5HDI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Membrane
messages: Probably involved in transport through the plasma membrane.

367110:NCU02963
gene id: 367110:NCU02963
uniprot id: Q7SH06
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

367110:NCU09247
gene id: 367110:NCU09247
uniprot id: Q7SF63
names: Similarity
messages: Belongs to the RRN3 family.

367110:NCU09249
gene id: 367110:NCU09249
uniprot id: Q7SF61
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

367110:NCU08310
gene id: 367110:NCU08310
uniprot id: Q7SA78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

367110:NCU02455
gene id: 367110:NCU02455
uniprot id: O60046
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family.
messages: Endoplasmic reticulum lumen
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

367110:NCU02064
gene id: 367110:NCU02064
uniprot id: Q7SEZ9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

367110:NCU04656
gene id: 367110:NCU04656
uniprot id: Q1K6F9
names: Subcellular Location Annotation
messages: Membrane

367110:NCU08503
gene id: 367110:NCU08503
uniprot id: Q7SC98
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPH1/DPH2 family. DPH1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. Dph-1 and dph-2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising dph-3 and a NADH-dependent reductase, predominantly cbr-1.
messages: Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of dph-1, dph-2, dph-3 and a NADH-dependent reductase, predominantly cbr-1.
messages: Cytoplasm

367110:NCU08945
gene id: 367110:NCU08945
uniprot id: Q1K6R8
names: Similarity
messages: Belongs to the REXO1/REXO3 family.

367110:NCU07125
gene id: 367110:NCU07125
uniprot id: Q7S6C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Membrane

367110:NCU08729
gene id: 367110:NCU08729
uniprot id: Q7SCG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF10 family.
messages: Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation), facilitation of DNA opening and initiation of transcription. SAGA is required for recruitment of the basal transcription machinery. SLIK is proposed to have partly overlapping functions with SAGA.
messages: Nucleus

367110:NCU09532
gene id: 367110:NCU09532
uniprot id: Q7RZZ0
names: Similarity
messages: Belongs to the DapA family.

367110:NCU07550
gene id: 367110:NCU07550
uniprot id: Q7S2Z9
names: Similarity
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Homodimer.

367110:NCU03031
gene id: 367110:NCU03031
uniprot id: Q7SGY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CybS family.
messages: Forms part of complex II containing four subunits: a flavoprotein (FP), an iron-sulfur protein (IP) and a cytochrome b composed of a large and a small subunit.
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

367110:NCU01806
gene id: 367110:NCU01806
uniprot id: Q1K542
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

367110:NCU08733
gene id: 367110:NCU08733
uniprot id: Q1K8U9
names: Function
names: Similarity
messages: Belongs to the MUB1/samB family.
messages: Involved in determination of the onset of polarized growth and morphogenesis. Plays a role in the regulation of branching in hyphae and spore formation.

367110:NCU01638
gene id: 367110:NCU01638
uniprot id: F5HFM2
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

367110:NCU07880
gene id: 367110:NCU07880
uniprot id: Q7SB13
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

367110:NCU09885
gene id: 367110:NCU09885
uniprot id: V5IQA9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

367110:NCU03888
gene id: 367110:NCU03888
uniprot id: Q7RZD9
names: Similarity
messages: Belongs to the SH3YL1 family.

367110:NCU00814
gene id: 367110:NCU00814
uniprot id: Q7SEC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTA1 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

367110:NCU06326
gene id: 367110:NCU06326
uniprot id: V5IMJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 1 family.
messages: Secreted

367110:NCU03138
gene id: 367110:NCU03138
uniprot id: Q7SDV2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

367110:NCU07623
gene id: 367110:NCU07623
uniprot id: Q7SB02
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

367110:NCU03065
gene id: 367110:NCU03065
uniprot id: Q7SCS6
names: Similarity
messages: Belongs to the RNR ribonuclease family.

367110:NCU01611
gene id: 367110:NCU01611
uniprot id: Q1K558
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

367110:NCU01236
gene id: 367110:NCU01236
uniprot id: Q9P737
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLX1 family.
messages: Catalytic subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
messages: Forms a heterodimer with slx4.
messages: Nucleus

367110:NCU04428
gene id: 367110:NCU04428
uniprot id: Q7RZ46
names: Similarity
messages: Belongs to the MAD1 family.

367110:NCU02542
gene id: 367110:NCU02542
uniprot id: V5IP39
uniprot id: V5IP98
names: Similarity
messages: Belongs to the hexokinase family.

367110:NCU05886
gene id: 367110:NCU05886
uniprot id: Q7S522
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

367110:NCU06042
gene id: 367110:NCU06042
uniprot id: Q7S508
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Binds 1 FAD per monomer.
messages: Irreversibly catalyzes the reduction of fumarate to succinate.

367110:NCU08594
gene id: 367110:NCU08594
uniprot id: Q7SCN4
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU08903
gene id: 367110:NCU08903
uniprot id: Q7S0A5
names: Similarity
messages: Belongs to the NOP10 family.

367110:NCU02582
gene id: 367110:NCU02582
uniprot id: Q92253
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane
messages: Probable glucose transporter. Involved in sugar transport, carbon catabolite repression, and initiation of conidiophore development.

367110:NCU06374
gene id: 367110:NCU06374
uniprot id: Q7S9T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

367110:NCU04221
gene id: 367110:NCU04221
uniprot id: O42783
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 37 family.
messages: Cytoplasm
messages: Hydrolyzes intracellular trehalose to glucose.
messages: Induced during conidial germination.
messages: Induced during recovery from thermal stress.

367110:NCU05622
gene id: 367110:NCU05622
uniprot id: Q7S5Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Secreted

367110:NCU02970
gene id: 367110:NCU02970
uniprot id: Q1K950
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

367110:NCU06563
gene id: 367110:NCU06563
uniprot id: Q1K8E8
names: Similarity
messages: Belongs to the PPP phosphatase family.

367110:NCU04044
gene id: 367110:NCU04044
uniprot id: P24917
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 51 kDa subunit family.
messages: Binds 1 FMN.
messages: Binds 1 [4Fe-4S] cluster.
messages: Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Mitochondrion inner membrane

367110:NCU00660
gene id: 367110:NCU00660
uniprot id: Q7SHZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.

367110:NCU04810
gene id: 367110:NCU04810
uniprot id: Q7S6M5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex (By similarity).

367110:NCU05591
gene id: 367110:NCU05591
uniprot id: Q7S6X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
messages: Membrane

367110:NCU04570
gene id: 367110:NCU04570
uniprot id: Q1K666
names: Similarity
messages: Belongs to the ADIP family.

367110:NCU08068
gene id: 367110:NCU08068
uniprot id: Q7SGL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex SPC19 family.
messages: Nucleus
messages: kinetochore

367110:NCU04953
gene id: 367110:NCU04953
uniprot id: Q7S3R4
names: Similarity
messages: Belongs to the peptidase A1 family.

367110:NCU07862
gene id: 367110:NCU07862
uniprot id: Q7SBU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SPP2 family.
messages: Involved in spliceosome maturation and the first step of pre-mRNA splicing.
messages: Nucleus

367110:NCU00920
gene id: 367110:NCU00920
uniprot id: Q7SFC7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

367110:NCU09784
gene id: 367110:NCU09784
uniprot id: Q7S5T7
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

367110:NCU04797
gene id: 367110:NCU04797
uniprot id: Q7S6N8
names: Similarity
messages: Belongs to the FBPase class 1 family.

367110:NCU08329
gene id: 367110:NCU08329
uniprot id: Q7SA60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins. uL23m forms the wall of the exit tunnel.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU03304
gene id: 367110:NCU03304
uniprot id: Q7SEN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

367110:NCU06922
gene id: 367110:NCU06922
uniprot id: V5IM90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

367110:NCU02233
gene id: 367110:NCU02233
uniprot id: Q7S4G1
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

367110:NCU03307
gene id: 367110:NCU03307
uniprot id: Q7SEN7
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU03741
gene id: 367110:NCU03741
uniprot id: Q1K7X2
names: Similarity
messages: Belongs to the NAD kinase family.

367110:NCU00520
gene id: 367110:NCU00520
uniprot id: Q7SCL7
names: Similarity
messages: Belongs to the TPA1 family.

367110:NCU01094
gene id: 367110:NCU01094
uniprot id: Q1K881
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

367110:NCU08052
gene id: 367110:NCU08052
uniprot id: Q7SGN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

367110:NCU04362
gene id: 367110:NCU04362
uniprot id: Q7RWR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the CWC26 family.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing.
messages: Nucleus

367110:NCU08035
gene id: 367110:NCU08035
uniprot id: O59941
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase D subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).
messages: Vacuole membrane

367110:NCU02322
gene id: 367110:NCU02322
uniprot id: Q7S4U2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

367110:NCU02317
gene id: 367110:NCU02317
uniprot id: Q7S418
names: Subunit
messages: Homodimer.

367110:NCU03361
gene id: 367110:NCU03361
uniprot id: Q1K504
names: Similarity
messages: Belongs to the BLOC1S1 family.

367110:NCU00560
gene id: 367110:NCU00560
uniprot id: Q7SF89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat IPI3/WDR18 family.
messages: Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.
messages: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.
messages: Nucleus

367110:NCU03850
gene id: 367110:NCU03850
uniprot id: Q7RW83
names: Subunit
messages: Homodimer.

367110:NCU05777
gene id: 367110:NCU05777
uniprot id: Q7S5R6
names: Similarity
messages: Belongs to the peptidase C19 family.

367110:NCU08935
gene id: 367110:NCU08935
uniprot id: Q7S7F6
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

367110:NCU02232
gene id: 367110:NCU02232
uniprot id: Q7S4G2
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

367110:NCU02167
gene id: 367110:NCU02167
uniprot id: Q7SEQ0
names: Subcellular Location Annotation
messages: Cell membrane

367110:NCU07774
gene id: 367110:NCU07774
uniprot id: P51599
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.
messages: GTP shows a positive allosteric effect, and tetrahydrobiopterin inhibits the enzyme activity.
messages: Toroid-shaped homodecamer, composed of two pentamers of five dimers.

367110:NCU09324
gene id: 367110:NCU09324
uniprot id: Q01285
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chitin synthase family. Class IV subfamily.
messages: Cell membrane
messages: Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.

367110:NCU08333
gene id: 367110:NCU08333
uniprot id: Q7SGS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Cytoplasm
messages: Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.
messages: Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.
messages: Mitochondrion
messages: The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.

367110:NCU09473
gene id: 367110:NCU09473
uniprot id: Q7SC08
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU00635
gene id: 367110:NCU00635
uniprot id: Q7SI17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. Npc-1/egd2 may also be involved in transcription regulation (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Part of the nascent polypeptide-associated complex (NAC), consisting of npc-1/egd2 and npc-2/egd1. NAC associates with ribosomes via npc-2/egd1 (By similarity).

367110:NCU00337
gene id: 367110:NCU00337
uniprot id: Q7RZM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.
messages: nucleolus

367110:NCU09909
gene id: 367110:NCU09909
uniprot id: Q7S147
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

367110:NCU09235
gene id: 367110:NCU09235
uniprot id: P10169
names: Developmental Stage
messages: Expressed early during conidial (dormant spores) differentiation.

367110:NCU04592
gene id: 367110:NCU04592
uniprot id: Q1K625
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU07851
gene id: 367110:NCU07851
uniprot id: Q7SBV7
names: Similarity
messages: Belongs to the CCS1 family.
messages: In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.

367110:NCU06267
gene id: 367110:NCU06267
uniprot id: U9W335
names: Similarity
messages: Belongs to the ATG16 family.

367110:NCU01166
gene id: 367110:NCU01166
uniprot id: Q01386
names: Similarity
names: Subunit
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer (By similarity).

367110:NCU06929
gene id: 367110:NCU06929
uniprot id: Q7S3C4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPT5 family.
messages: Component of the spt4-spt5 complex. Interacts with RNA polymerase II (By similarity).
messages: Nucleus
messages: The spt4-spt5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).

367110:NCU06881
gene id: 367110:NCU06881
uniprot id: Q7S3H2
names: Function
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.

367110:NCU04760
gene id: 367110:NCU04760
uniprot id: Q7S693
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP18 family.
messages: Golgi apparatus membrane
messages: Golgi membrane protein involved in vesicular trafficking.

367110:NCU02514
gene id: 367110:NCU02514
uniprot id: P37211
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity).
messages: Mitochondrion
messages: Mitochondrion inner membrane

367110:NCU04402
gene id: 367110:NCU04402
uniprot id: Q8X225
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
messages: Chromosome
messages: Histone methyltransferase that specifically trimethylates histone H3 to form H3K9me3. H3K9me3 marks chromatin regions for DNA methylation (PubMed:11713521, PubMed:12372305, PubMed:12679815, PubMed:12887903). Dim-5 recognizes Arg-8 to Gly-12 of the H3 tail with Thr-11 and Gly-12 being the most important specificity determinants, the recognition of whcih is important to distinguish H3K9 from H3K27 and H4K20 (PubMed:18215768).
messages: In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.
messages: Nucleus

367110:NCU16474
gene id: 367110:NCU16474
uniprot id: V5IQC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBT5 family.
messages: Membrane

367110:NCU06630
gene id: 367110:NCU06630
uniprot id: P48580
names: Cofactor
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2A subfamily.
messages: Binds 2 manganese ions per subunit.

367110:NCU11220
gene id: 367110:NCU11220
uniprot id: A7UW18
names: Similarity
messages: Belongs to the Nth/MutY family.

367110:NCU08897
gene id: 367110:NCU08897
uniprot id: Q870W0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity).
messages: Belongs to the SecY/SEC61-alpha family.
messages: Endoplasmic reticulum membrane
messages: Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.

367110:NCU03717
gene id: 367110:NCU03717
uniprot id: Q7S7Y2
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

367110:NCU01768
gene id: 367110:NCU01768
uniprot id: Q7RU87
names: Similarity
messages: Belongs to the glycosyl hydrolase 63 family.

367110:NCU01388
gene id: 367110:NCU01388
uniprot id: Q1K6Z7
names: Similarity
messages: Belongs to the glycosyltransferase 15 family.

367110:NCU06892
gene id: 367110:NCU06892
uniprot id: Q7S3G1
names: Similarity
messages: Belongs to the universal ribosomal protein uS10 family.

367110:NCU09091
gene id: 367110:NCU09091
uniprot id: Q7SFQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.
messages: Homopentamer. Forms homooligomers. Interacts with MFM1.
messages: Mitochondrion inner membrane

367110:NCU05884
gene id: 367110:NCU05884
uniprot id: Q7S524
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06845
gene id: 367110:NCU06845
uniprot id: Q1K8K7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU01552
gene id: 367110:NCU01552
uniprot id: Q9HE74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Cytoplasm

367110:NCU16007
gene id: 367110:NCU16007
uniprot id: Q35141
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 3 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Mitochondrion membrane

367110:NCU00944
gene id: 367110:NCU00944
uniprot id: Q7SGH8
names: Similarity
messages: Belongs to the threonine aldolase family.

367110:NCU05299
gene id: 367110:NCU05299
uniprot id: P24919
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA5 subunit family.
messages: Complex I is composed of about 40 different subunits.
messages: Mitochondrion inner membrane

367110:NCU10008
gene id: 367110:NCU10008
uniprot id: Q7S3Z6
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.

367110:NCU03339
gene id: 367110:NCU03339
uniprot id: Q873E8
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: Maintains high levels of reduced glutathione in the cytosol.
messages: The active site is a redox-active disulfide bond.

367110:NCU03703
gene id: 367110:NCU03703
uniprot id: Q9HE25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Component of the large ribosomal subunit (LSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

367110:NCU05814
gene id: 367110:NCU05814
uniprot id: Q7S5M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBT5 family.
messages: Membrane

367110:NCU02202
gene id: 367110:NCU02202
uniprot id: Q7S470
names: Subcellular Location Annotation
messages: Membrane

367110:NCU07307
gene id: 367110:NCU07307
uniprot id: V5IMJ4
names: Similarity
messages: Belongs to the fungal fatty acid synthetase subunit beta family.

367110:NCU04671
gene id: 367110:NCU04671
uniprot id: Q1K6F3
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU16368
gene id: 367110:NCU16368
uniprot id: V5IP57
names: Similarity
messages: Belongs to the DSD1 family.

367110:NCU01200
gene id: 367110:NCU01200
uniprot id: Q7S7Z6
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.
messages: Endoplasmic reticulum lumen
messages: Inhibited by cyclosporin A (CsA).
messages: Lacks the C-terminal transmembrane domain, but has an ER retention motif at its extreme C-terminus.
messages: Membrane
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

367110:NCU00751
gene id: 367110:NCU00751
uniprot id: Q7SDS2
names: Similarity
messages: Belongs to the asaB hydroxylase/desaturase family.

367110:NCU01252
gene id: 367110:NCU01252
uniprot id: Q1K6K2
names: Function
names: Similarity
messages: Belongs to the MUB1/samB family.
messages: Involved in determination of the onset of polarized growth and morphogenesis. Plays a role in the regulation of branching in hyphae and spore formation.

367110:NCU01596
gene id: 367110:NCU01596
uniprot id: Q1K564
names: Similarity
messages: Belongs to the proteasome subunit S9 family.

367110:NCU03558
gene id: 367110:NCU03558
uniprot id: Q1K4W1
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.

367110:NCU00669
gene id: 367110:NCU00669
uniprot id: Q7SHY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDOST 48 kDa subunit family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).

367110:NCU04322
gene id: 367110:NCU04322
uniprot id: Q1K718
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03337
gene id: 367110:NCU03337
uniprot id: V5IP87
uniprot id: V5IPS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

367110:NCU02701
gene id: 367110:NCU02701
uniprot id: Q7SH28
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M49 family.
messages: Binds 1 zinc ion per subunit.

367110:NCU00789
gene id: 367110:NCU00789
uniprot id: Q7SFU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

367110:NCU08110
gene id: 367110:NCU08110
uniprot id: Q7SCX0
names: Subcellular Location Annotation
messages: Membrane
messages: Vacuole membrane

367110:NCU03678
gene id: 367110:NCU03678
uniprot id: Q96UB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSH4 family.
messages: Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane (By similarity).
messages: Endosome membrane
messages: Vacuole membrane

367110:NCU05499
gene id: 367110:NCU05499
uniprot id: Q7S6U0
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

367110:NCU09410
gene id: 367110:NCU09410
uniprot id: Q7S282
names: Subcellular Location Annotation
messages: Membrane

367110:NCU07590
gene id: 367110:NCU07590
uniprot id: Q7SBG6
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

367110:NCU06137
gene id: 367110:NCU06137
uniprot id: Q7S5F1
names: Similarity
messages: Belongs to the cytochrome P450 family.

367110:NCU04109
gene id: 367110:NCU04109
uniprot id: Q1K7N7
names: Similarity
messages: Belongs to the GST superfamily.

367110:NCU09553
gene id: 367110:NCU09553
uniprot id: Q7S2A8
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

367110:NCU06473
gene id: 367110:NCU06473
uniprot id: Q7RYU7
names: Subcellular Location Annotation
messages: Membrane

367110:NCU07014
gene id: 367110:NCU07014
uniprot id: P27770
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS17 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Cytoplasm

367110:NCU01151
gene id: 367110:NCU01151
uniprot id: Q7S7N5
names: Similarity
messages: Belongs to the peptidase C2 family. PalB/RIM13 subfamily.

367110:NCU05923
gene id: 367110:NCU05923
uniprot id: Q7S0Y1
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

367110:NCU02776
gene id: 367110:NCU02776
uniprot id: Q7SE18
names: Similarity
messages: Belongs to the CDC6/cdc18 family.

367110:NCU04265
gene id: 367110:NCU04265
uniprot id: Q1K7I2
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

367110:NCU02403
gene id: 367110:NCU02403
uniprot id: Q7S4N2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ9 family.
messages: Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
messages: Mitochondrion

367110:NCU09696
gene id: 367110:NCU09696
uniprot id: Q1K6J6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: srp72, srp68, srp54, sec65, srp21 and srp14.
messages: Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes. SRP54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit SRP101. Both, SRP54 and SRP101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon). After signal sequence transfer, SRP54 and SRP101 act as reciprocal GTPase-activating proteins (GAPs), thereby resolving their association.
messages: The M domain binds the 7SL RNA and the signal sequence of presecretory proteins.
messages: The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit srp101. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

367110:NCU10597
gene id: 367110:NCU10597
uniprot id: A7UW19
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU00273
gene id: 367110:NCU00273
uniprot id: Q7RZU0
names: Similarity
messages: Belongs to the NUP186/NUP192/NUP205 family.

367110:NCU04549
gene id: 367110:NCU04549
uniprot id: Q7RWE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX20 family.
messages: Involved in the assembly of the cytochrome c oxidase complex.
messages: Mitochondrion inner membrane

367110:NCU05041
gene id: 367110:NCU05041
uniprot id: Q7RX47
names: Similarity
messages: In the C-terminal section; belongs to the trehalose phosphatase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 20 family.

367110:NCU03344
gene id: 367110:NCU03344
uniprot id: Q1K525
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ALG14 family.
messages: Endoplasmic reticulum membrane
messages: Heterodimer with ALG13 to form a functional enzyme.
messages: Membrane
messages: Nucleus membrane

367110:NCU02669
gene id: 367110:NCU02669
uniprot id: Q7SH60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS10-related sortilin family.
messages: Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment (By similarity).
messages: Prevacuolar compartment membrane
messages: trans-Golgi network membrane

367110:NCU09337
gene id: 367110:NCU09337
uniprot id: Q7S130
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRM1 family.
messages: Cell membrane
messages: Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.

367110:NCU04177
gene id: 367110:NCU04177
uniprot id: Q9C245
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog nit-1/uba4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as ahp1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of nit-1/uba4, then thiocarboxylated (-COSH) via the rhodanese domain of nit-1/uba4.
messages: Cytoplasm

367110:NCU09349
gene id: 367110:NCU09349
uniprot id: Q7S2N9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
messages: Associates in the nucleolus with the 60S and pre-60S ribosomal subunits.
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

367110:NCU07337
gene id: 367110:NCU07337
uniprot id: Q7SA26
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

367110:NCU06347
gene id: 367110:NCU06347
uniprot id: Q7S9V9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the END3 family.
messages: Cell membrane
messages: Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
messages: Component of the PAN1 actin cytoskeleton-regulatory complex.
messages: Endosome membrane
messages: actin patch

367110:NCU07386
gene id: 367110:NCU07386
uniprot id: Q7S2H6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS42 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins. mS42 forms a homodimer, in contrast to the mS42-mS43 heterodimer in yeast, building a large protuberance adjacent to the mRNA channel exit in the mt-SSU body.
messages: Mitochondrion

367110:NCU00812
gene id: 367110:NCU00812
uniprot id: Q7SEC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

367110:NCU04830
gene id: 367110:NCU04830
uniprot id: Q7S6K5
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU00372
gene id: 367110:NCU00372
uniprot id: Q7RYT7
names: Similarity
messages: Belongs to the THADA family.

367110:NCU03133
gene id: 367110:NCU03133
uniprot id: Q7SDV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

367110:NCU09492
gene id: 367110:NCU09492
uniprot id: V5IQD4
names: Similarity
messages: Belongs to the DOCK family.

367110:NCU00280
gene id: 367110:NCU00280
uniprot id: Q7RZT4
names: Similarity
messages: Belongs to the COG1 family.

367110:NCU03576
gene id: 367110:NCU03576
uniprot id: Q1K4S9
names: Similarity
messages: Belongs to the Mo25 family.

367110:NCU01799
gene id: 367110:NCU01799
uniprot id: Q1K549
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex DAD3 family.
messages: Nucleus
messages: kinetochore
messages: spindle

367110:NCU07711
gene id: 367110:NCU07711
uniprot id: Q7S9J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Membrane

367110:NCU00593
gene id: 367110:NCU00593
uniprot id: Q7SI58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN2 family.
messages: Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity). The CSN complex is involved in the regulation of the circadian clock through its control of the stability of the SCF(FWD-1) complex.
messages: Component of the COP9 signalosome (CSN) complex.
messages: Cytoplasm
messages: Nucleus

367110:NCU00158
gene id: 367110:NCU00158
uniprot id: Q7RXQ0
names: Similarity
messages: Belongs to the PRP18 family.

367110:NCU07814
gene id: 367110:NCU07814
uniprot id: Q7S042
names: Domain
names: Function
names: Similarity
messages: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.
messages: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

367110:NCU01761
gene id: 367110:NCU01761
uniprot id: Q1K5R0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Mitochondrion

367110:NCU05495
gene id: 367110:NCU05495
uniprot id: Q7S6U4
names: Function
names: Similarity
messages: Belongs to the cyanovirin-N family.
messages: Mannose-binding lectin.

367110:NCU02460
gene id: 367110:NCU02460
uniprot id: V5IKE1
uniprot id: V5IKK0
uniprot id: V5IMH2
names: Similarity
messages: Belongs to the syntaxin family.

367110:NCU05539
gene id: 367110:NCU05539
uniprot id: Q7S724
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2H phosphoesterase superfamily. CPD1 family.
messages: Golgi apparatus
messages: Involved in the metabolism of ADP-ribose 1',2'-cyclic phosphate which is produced as a consequence of tRNA splicing.

367110:NCU02758
gene id: 367110:NCU02758
uniprot id: Q7SCX6
names: Similarity
messages: Belongs to the cyclin family.

367110:NCU01356
gene id: 367110:NCU01356
uniprot id: Q1K6N8
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Exports stored molybdate from the vacuole into the cytosol, making it available for molybdate cofactor (Moco) biosynthesis (PubMed:36240974). Plays a role in molybdate homeostasis as high cytosolic levels of molybdate are toxic to cells (PubMed:36240974). Not required for molybdate import into cells (PubMed:36240974).
messages: Resistance to molybdate.
messages: Vacuole membrane

367110:NCU05154
gene id: 367110:NCU05154
uniprot id: Q1K588
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

367110:NCU10907
gene id: 367110:NCU10907
uniprot id: A7UXG4
names: Similarity
messages: Belongs to the peptidase A1 family.

367110:NCU06508
gene id: 367110:NCU06508
uniprot id: Q7RYG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU01092
gene id: 367110:NCU01092
uniprot id: Q1K883
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU03289
gene id: 367110:NCU03289
uniprot id: Q7SDW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF6 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
messages: Component of the NuA4 histone acetyltransferase complex.
messages: Nucleus

367110:NCU04488
gene id: 367110:NCU04488
uniprot id: Q7RYB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

367110:NCU00758
gene id: 367110:NCU00758
uniprot id: Q7SDR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

367110:NCU01867
gene id: 367110:NCU01867
uniprot id: Q7SHD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 61 family.
messages: Secreted

367110:NCU07407
gene id: 367110:NCU07407
uniprot id: Q7S0U7
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.
messages: Component of the post-replicative DNA mismatch repair system (MMR).

367110:NCU06785
gene id: 367110:NCU06785
uniprot id: Q8X097
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols.
messages: Composed of two subunits.
messages: Cytoplasm

367110:NCU00570
gene id: 367110:NCU00570
uniprot id: Q7SF80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

367110:NCU05094
gene id: 367110:NCU05094
uniprot id: V5ILQ2
uniprot id: V5INH6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU00943
gene id: 367110:NCU00943
uniprot id: Q7SGH9
names: Similarity
messages: Belongs to the glycosyl hydrolase 37 family.

367110:NCU04898
gene id: 367110:NCU04898
uniprot id: Q7S1D7
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.

367110:NCU03769
gene id: 367110:NCU03769
uniprot id: Q1K7A9
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

367110:NCU01852
gene id: 367110:NCU01852
uniprot id: V5IP12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

367110:NCU01323
gene id: 367110:NCU01323
uniprot id: Q1K7U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Nucleus

367110:NCU05552
gene id: 367110:NCU05552
uniprot id: Q7S711
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU01342
gene id: 367110:NCU01342
uniprot id: Q9HEK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum (By similarity).
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

367110:NCU07922
gene id: 367110:NCU07922
uniprot id: Q7S9Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.
messages: cytoskeleton

367110:NCU05837
gene id: 367110:NCU05837
uniprot id: Q7S5K6
names: Function
names: Similarity
messages: Belongs to the VPS13 family.
messages: Mediates the transfer of lipids between membranes at organelle contact sites. May play a role in mitochondrial lipid homeostasis.

367110:NCU02595
gene id: 367110:NCU02595
uniprot id: Q7SG25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMP46 family.
messages: Mitochondrion
messages: Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.

367110:NCU06595
gene id: 367110:NCU06595
uniprot id: Q7S9S0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS36 family.
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).
messages: Cytoplasm
messages: Endosome

367110:NCU05999
gene id: 367110:NCU05999
uniprot id: Q7S2F7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
messages: Heterodimer of an alpha and a beta subunit.

367110:NCU07955
gene id: 367110:NCU07955
uniprot id: Q7S930
names: Function
names: Similarity
messages: Belongs to the MDM31/MDM32 family.
messages: Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.

367110:NCU01702
gene id: 367110:NCU01702
uniprot id: Q7RVQ2
names: Similarity
messages: Belongs to the nucleoporin interacting component (NIC) family.

367110:NCU09297
gene id: 367110:NCU09297
uniprot id: Q7S1I4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND1 (condensin subunit 1) family.
messages: Chromosome
messages: Nucleus
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

367110:NCU06428
gene id: 367110:NCU06428
uniprot id: Q7RYY7
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

367110:NCU04481
gene id: 367110:NCU04481
uniprot id: Q7RYC6
names: Similarity
messages: Belongs to the AFG1 ATPase family.

367110:NCU08997
gene id: 367110:NCU08997
uniprot id: U9W3G5
uniprot id: U9W3L2
names: Cofactor
names: Similarity
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.

367110:NCU02238
gene id: 367110:NCU02238
uniprot id: Q7S441
names: Subcellular Location Annotation
messages: Membrane

367110:NCU00066
gene id: 367110:NCU00066
uniprot id: Q7RX84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the CWC22 family.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing.
messages: Nucleus

367110:NCU06704
gene id: 367110:NCU06704
uniprot id: Q1K6Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.

367110:NCU16657
gene id: 367110:NCU16657
uniprot id: U9W8A6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

367110:NCU06075
gene id: 367110:NCU06075
uniprot id: Q7RVA8
names: Similarity
names: Subunit
messages: Belongs to the pyruvate kinase family.
messages: Homotetramer.

367110:NCU08067
gene id: 367110:NCU08067
uniprot id: Q7SGL6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHO1 family.
messages: Cell membrane
messages: Forms homooligomers.
messages: Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity.

367110:NCU06433
gene id: 367110:NCU06433
uniprot id: Q7RYY4
names: Function
names: Similarity
messages: Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

367110:NCU01894
gene id: 367110:NCU01894
uniprot id: Q7SHB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS45 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Mitochondrion

367110:NCU08428
gene id: 367110:NCU08428
uniprot id: Q7SC88
names: Subcellular Location Annotation
messages: Membrane

367110:NCU05246
gene id: 367110:NCU05246
uniprot id: Q7S8T9
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU02023
gene id: 367110:NCU02023
uniprot id: Q7SF41
names: Subcellular Location Annotation
messages: Membrane

367110:NCU08402
gene id: 367110:NCU08402
uniprot id: Q7SC51
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

367110:NCU00547
gene id: 367110:NCU00547
uniprot id: Q7SFA1
names: Subcellular Location Annotation
messages: Membrane

367110:NCU05047
gene id: 367110:NCU05047
uniprot id: Q7RXD7
names: Similarity
messages: Belongs to the RRP1 family.

367110:NCU06994
gene id: 367110:NCU06994
uniprot id: Q7SAF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the CEF1 family.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing and cell cycle control.
messages: Nucleus

367110:NCU04454
gene id: 367110:NCU04454
uniprot id: Q7RWB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU05423
gene id: 367110:NCU05423
uniprot id: Q9P5N7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB1 family.
messages: Component of the 7-subunit TFIIH core complex composed of XPB/rad25, XPD/dnr-10, tcf-30/SSL1, tcf-29/TFB1, tcf-11/TFB2, tcf-14/TFB4 and rtf-1/TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of div-66/cyclin H, prk-3/KIN28 and rtf-2/TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
messages: Nucleus

367110:NCU04987
gene id: 367110:NCU04987
uniprot id: Q7S0E1
names: Subcellular Location Annotation
messages: Membrane

367110:NCU07294
gene id: 367110:NCU07294
uniprot id: Q7S973
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU06043
gene id: 367110:NCU06043
uniprot id: Q7S507
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

367110:NCU01803
gene id: 367110:NCU01803
uniprot id: Q1K545
names: Similarity
messages: Belongs to the R-transferase family.

367110:NCU01417
gene id: 367110:NCU01417
uniprot id: Q7S7A6
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

367110:NCU09635
gene id: 367110:NCU09635
uniprot id: Q7S0U1
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

367110:NCU09468
gene id: 367110:NCU09468
uniprot id: P38669
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

367110:NCU02813
gene id: 367110:NCU02813
uniprot id: Q7SEK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit M family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

367110:NCU03806
gene id: 367110:NCU03806
uniprot id: P08978
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Component of the large ribosomal subunit (LSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

367110:NCU06422
gene id: 367110:NCU06422
uniprot id: Q7RYZ3
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

367110:NCU06011
gene id: 367110:NCU06011
uniprot id: Q7S2E6
names: Subcellular Location Annotation
messages: Membrane

367110:NCU11175
gene id: 367110:NCU11175
uniprot id: P0C2N8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in ribosome assembly.
messages: Associates with pre-ribosomal particles.
messages: Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

367110:NCU05042
gene id: 367110:NCU05042
uniprot id: Q7RX46
names: Similarity
messages: Belongs to the multicopper oxidase family.

367110:NCU03131
gene id: 367110:NCU03131
uniprot id: Q7SFW4
names: Similarity
messages: Belongs to the DAMOX/DASOX family.

367110:NCU02463
gene id: 367110:NCU02463
uniprot id: Q7SG99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

367110:NCU07075
gene id: 367110:NCU07075
uniprot id: V5ILA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.
messages: Membrane
messages: Vacuole membrane

367110:NCU01169
gene id: 367110:NCU01169
uniprot id: P40915
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Mitochondrion inner membrane

367110:NCU05060
gene id: 367110:NCU05060
uniprot id: Q7RXC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBT5 family.
messages: Membrane

367110:NCU03372
gene id: 367110:NCU03372
uniprot id: Q1K4Z8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

367110:NCU11342
gene id: 367110:NCU11342
uniprot id: A7UWW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU07022
gene id: 367110:NCU07022
uniprot id: Q7S9B3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

367110:NCU04737
gene id: 367110:NCU04737
uniprot id: Q7S6G9
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.

367110:NCU03312
gene id: 367110:NCU03312
uniprot id: Q7SEN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

367110:NCU08728
gene id: 367110:NCU08728
uniprot id: Q1K8V2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Mitochondrion

367110:NCU09364
gene id: 367110:NCU09364
uniprot id: P19752
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: The N-terminal putative helical domain may be the site through which HSP30 binding to mitochondrial membrane is regulated.

367110:NCU01516
gene id: 367110:NCU01516
uniprot id: Q9P5U4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Component of the PAM complex, at least composed of hsp70-5/ssc1, grpe/mge1, tim44, un-4/pam16, pam17 and tim14/pam18.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mtHSP70 (hsp70-5) to substrate proteins (By similarity).
messages: Mitochondrion matrix

367110:NCU02913
gene id: 367110:NCU02913
uniprot id: Q7SHJ1
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU04519
gene id: 367110:NCU04519
uniprot id: Q7RY44
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).
messages: Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity). SPC associates with the translocon complex (By similarity).
messages: Endoplasmic reticulum membrane
messages: The C-terminal short (CTS) helix is essential for catalytic activity. It may be accommodated as a transmembrane helix in the thinned membrane environment of the complex, similarly to the signal peptide in the complex substrates.

367110:NCU05263
gene id: 367110:NCU05263
uniprot id: Q7S8C2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

367110:NCU01210
gene id: 367110:NCU01210
uniprot id: Q1K835
names: Similarity
messages: In the C-terminal section; belongs to the anthranilate synthase component I family.

367110:NCU08688
gene id: 367110:NCU08688
uniprot id: Q7S868
names: Similarity
messages: Belongs to the TTI2 family.

367110:NCU04461
gene id: 367110:NCU04461
uniprot id: Q7RYE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU00115
gene id: 367110:NCU00115
uniprot id: Q7RYL3
names: Subcellular Location Annotation
messages: nucleolus

367110:NCU02059
gene id: 367110:NCU02059
uniprot id: Q7SDD9
names: Similarity
messages: Belongs to the peptidase A1 family.

367110:NCU09264
gene id: 367110:NCU09264
uniprot id: Q7SF46
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
messages: Cytoplasm

367110:NCU07053
gene id: 367110:NCU07053
uniprot id: Q7S5U4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

367110:NCU04845
gene id: 367110:NCU04845
uniprot id: Q7S6J0
names: Similarity
messages: Belongs to the PhyH family.

367110:NCU09733
gene id: 367110:NCU09733
uniprot id: Q7SEJ2
names: Similarity
messages: Belongs to the SUN family.

367110:NCU08554
gene id: 367110:NCU08554
uniprot id: O60045
names: Function
messages: Site-specific PPIase with respect to the amino acid N-terminal to the proline residue. Peptides with glutamate, phosphoserine, or phosphothreonine in the -1 position are the best substrates. It is not only able to isomerize small peptides but is also active in protein folding.

367110:NCU06354
gene id: 367110:NCU06354
uniprot id: Q7S9V2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.
messages: Nucleus

367110:NCU04928
gene id: 367110:NCU04928
uniprot id: Q7S3T9
names: Similarity
messages: Belongs to the ustYa family.

367110:NCU01474
gene id: 367110:NCU01474
uniprot id: V5IMN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU06491
gene id: 367110:NCU06491
uniprot id: Q7RYI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWC5 family.
messages: Component of the SWR1 chromatin remodeling complex.
messages: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity).
messages: Nucleus

367110:NCU08027
gene id: 367110:NCU08027
uniprot id: Q7SAL4
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

367110:NCU00924
gene id: 367110:NCU00924
uniprot id: Q7SFC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU00676
gene id: 367110:NCU00676
uniprot id: Q7SHX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

367110:NCU06656
gene id: 367110:NCU06656
uniprot id: P87000
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Positive regulator of acetate induction.
messages: The glutamine-rich domain might function in activating gene expression.

367110:NCU07795
gene id: 367110:NCU07795
uniprot id: Q7S0K3
names: Similarity
messages: Belongs to the RRP15 family.

367110:NCU02946
gene id: 367110:NCU02946
uniprot id: V5IR83
uniprot id: V5IRS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

367110:NCU03483
gene id: 367110:NCU03483
uniprot id: Q01397
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dynactin 150 kDa subunit family.
messages: Cytoplasm
messages: Large macromolecular complex of at least 10 components; p150(glued) binds directly to microtubules and to cytoplasmic dynein.
messages: Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles (By similarity).
messages: cytoskeleton

367110:NCU01207
gene id: 367110:NCU01207
uniprot id: P11592
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).
messages: Endomembrane system
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).
messages: Vacuole membrane

367110:NCU04754
gene id: 367110:NCU04754
uniprot id: Q7S699
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

367110:NCU06943
gene id: 367110:NCU06943
uniprot id: Q7S0H3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: Required for pre-18S rRNA processing. May bind microtubules.
messages: nucleolus

367110:NCU05188
gene id: 367110:NCU05188
uniprot id: Q7S8D7
names: Similarity
messages: Belongs to the PheA/TfdB FAD monooxygenase family.

367110:NCU01849
gene id: 367110:NCU01849
uniprot id: Q7SD19
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

367110:NCU08981
gene id: 367110:NCU08981
uniprot id: Q7S2Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the misato family.
messages: Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.
messages: Mitochondrion

367110:NCU08407
gene id: 367110:NCU08407
uniprot id: Q7SC46
names: Subcellular Location Annotation
messages: Membrane

367110:NCU05157
gene id: 367110:NCU05157
uniprot id: Q1K585
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06610
gene id: 367110:NCU06610
uniprot id: Q7S9Q5
names: Subcellular Location Annotation
messages: Membrane

367110:NCU04823
gene id: 367110:NCU04823
uniprot id: V5IKV9
uniprot id: V5IN22
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

367110:NCU07282
gene id: 367110:NCU07282
uniprot id: Q7S985
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEF1 family.
messages: Cytoplasm
messages: Nucleus
messages: telomere

367110:NCU02417
gene id: 367110:NCU02417
uniprot id: Q7S4E2
names: Similarity
messages: Belongs to the acetyltransferase family. MAK3 subfamily.

367110:NCU09450
gene id: 367110:NCU09450
uniprot id: Q7S0G3
names: Function
names: Similarity
messages: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the proteasome subunit S1 family.

367110:NCU07289
gene id: 367110:NCU07289
uniprot id: V5IMU9
names: Similarity
messages: Belongs to the TFIIB family.

367110:NCU09194
gene id: 367110:NCU09194
uniprot id: Q1K6E5
names: Similarity
messages: Belongs to the nuclease type I family.

367110:NCU17114
gene id: 367110:NCU17114
uniprot id: V5IM60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL33 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins. bL33m stabilizes the tRNA acceptor stem in the E-site.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU05807
gene id: 367110:NCU05807
uniprot id: Q7S5N6
names: Similarity
messages: Belongs to the isochorismatase family.

367110:NCU09488
gene id: 367110:NCU09488
uniprot id: Q7SBZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDA1 family.
messages: Required for 60S pre-ribosomal subunits export to the cytoplasm.
messages: nucleolus

367110:NCU01979
gene id: 367110:NCU01979
uniprot id: Q7SE81
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

367110:NCU01036
gene id: 367110:NCU01036
uniprot id: Q1K8C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor potential (TRP) ion channel family.
messages: Membrane

367110:NCU09129
gene id: 367110:NCU09129
uniprot id: Q7S2L9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COA3 family.
messages: Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.
messages: Membrane
messages: Required for assembly of cytochrome c oxidase (complex IV).

367110:NCU02344
gene id: 367110:NCU02344
uniprot id: Q7S411
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 61 family.
messages: Secreted

367110:NCU07091
gene id: 367110:NCU07091
uniprot id: Q7S684
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anthrone oxygenase family.
messages: Membrane

367110:NCU05282
gene id: 367110:NCU05282
uniprot id: Q7S8K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: microtubule organizing center

367110:NCU00592
gene id: 367110:NCU00592
uniprot id: Q7SI59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the CWC25 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

367110:NCU04552
gene id: 367110:NCU04552
uniprot id: P21772
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS26 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Cytoplasm

367110:NCU06248
gene id: 367110:NCU06248
uniprot id: Q7SBQ9
names: Similarity
messages: Belongs to the IWR1/SLC7A6OS family.

367110:NCU00034
gene id: 367110:NCU00034
uniprot id: U9W2Z2
uniprot id: U9W347
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU02562
gene id: 367110:NCU02562
uniprot id: Q7SHQ3
names: Subcellular Location Annotation
messages: Membrane

367110:NCU00163
gene id: 367110:NCU00163
uniprot id: Q7RXP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity).
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane

367110:NCU01980
gene id: 367110:NCU01980
uniprot id: Q7SE80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRM44 family.
messages: Cytoplasm
messages: Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.

367110:NCU04404
gene id: 367110:NCU04404
uniprot id: Q7RZ70
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

367110:NCU00792
gene id: 367110:NCU00792
uniprot id: Q7SFT9
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

367110:NCU02359
gene id: 367110:NCU02359
uniprot id: Q7S4W7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INP1 family.
messages: Membrane
messages: Peroxisome membrane
messages: Required for peroxisome inheritance.

367110:NCU01949
gene id: 367110:NCU01949
uniprot id: Q7SDY7
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

367110:NCU05485
gene id: 367110:NCU05485
uniprot id: Q8TG12
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Phosphorylated by alpha subunit.
messages: Regulatory subunit of casein kinase II/CK2 (By similarity). As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (By similarity).
messages: Tetramer composed of two alpha chains, one beta chain and one beta' chain.

367110:NCU04781
gene id: 367110:NCU04781
uniprot id: Q7S628
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA1 subunit family.
messages: Mitochondrion inner membrane

367110:NCU05298
gene id: 367110:NCU05298
uniprot id: P08619
names: Cofactor
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the nitrate reductase family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 1 heme group per subunit. The heme group is called cytochrome b-557.
messages: Homodimer.
messages: Its expression is highly regulated and responds rapidly to nitrate induction and to nitrogen repression.
messages: Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.

367110:NCU05312
gene id: 367110:NCU05312
uniprot id: Q7S8M2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC24 family.
messages: Component of the NDC80 complex, which consists of kpr-1/ndc80, kpr-2/nuf2, kpr-3/spc24 and kpr-4/spc25.
messages: Nucleus
messages: kinetochore
messages: spindle pole body

367110:NCU00505
gene id: 367110:NCU00505
uniprot id: V5IR69
uniprot id: V5IRG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.

367110:NCU06987
gene id: 367110:NCU06987
uniprot id: Q7SAG3
names: Subcellular Location Annotation
messages: Membrane

367110:NCU01977
gene id: 367110:NCU01977
uniprot id: V5IQ43
uniprot id: V5IQL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

367110:NCU00597
gene id: 367110:NCU00597
uniprot id: Q7SI54
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily.

367110:NCU02217
gene id: 367110:NCU02217
uniprot id: Q7S4H6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX23 family.
messages: Mitochondrion intermembrane space
messages: Required for the assembly of cytochrome c oxidase.

367110:NCU06449
gene id: 367110:NCU06449
uniprot id: Q3Y3Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Membrane

367110:NCU04410
gene id: 367110:NCU04410
uniprot id: Q7RZ64
names: Similarity
messages: Belongs to the TRL1 family.

367110:NCU09640
gene id: 367110:NCU09640
uniprot id: Q7S0T6
names: Subcellular Location Annotation
messages: Membrane

367110:NCU07329
gene id: 367110:NCU07329
uniprot id: Q7SA34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

367110:NCU09789
gene id: 367110:NCU09789
uniprot id: Q7S604
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).

367110:NCU16549
gene id: 367110:NCU16549
uniprot id: V5IPD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DLT1 family.
messages: Membrane
messages: Required for growth under high-pressure and low-temperature conditions.

367110:NCU04180
gene id: 367110:NCU04180
uniprot id: Q1K7E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

367110:NCU08161
gene id: 367110:NCU08161
uniprot id: Q7S4I9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RTT106 family.
messages: Chromosome
messages: Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter (By similarity).
messages: Interacts with histones H3 and H4.
messages: Nucleus

367110:NCU03592
gene id: 367110:NCU03592
uniprot id: Q7S7W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

367110:NCU09757
gene id: 367110:NCU09757
uniprot id: Q7S0W0
names: Function
messages: Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

367110:NCU08232
gene id: 367110:NCU08232
uniprot id: Q7S3L1
names: Similarity
messages: Belongs to the glycosyltransferase 32 family.

367110:NCU08296
gene id: 367110:NCU08296
uniprot id: Q7SA90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins. uS3m, uS4m and uS5m form the narrow entry site of the mRNA channel.
messages: Mitochondrion

367110:NCU09223
gene id: 367110:NCU09223
uniprot id: Q7S399
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen
messages: Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.

367110:NCU07298
gene id: 367110:NCU07298
uniprot id: Q7S970
names: Similarity
messages: Belongs to the CoA-transferase III family.

367110:NCU02725
gene id: 367110:NCU02725
uniprot id: Q7SGC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPR3 family.
messages: Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.
messages: Vacuole membrane

367110:NCU02549
gene id: 367110:NCU02549
uniprot id: P11913
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family.
messages: Binding to mpp is required for catalytic activity (PubMed:2967109). Inhibited by metal chelator ethylenediaminetetraacetic acid (EDTA) (PubMed:2967109).
messages: Binds 1 zinc ion per subunit.
messages: Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (PubMed:2967109). Preferentially, cleaves after an arginine at position P2 (PubMed:8106471).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Heterodimer of mpp (alpha) and pep (beta) subunits, forming the mitochondrial processing protease (MPP) in which mpp is involved in substrate recognition and binding and pep is the catalytic subunit (PubMed:2967109). Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (cob), cytochrome c1 (cyt-1) and Rieske protein (fes-1), 2 core protein subunits pep and ucr-1, and 5 low-molecular weight protein subunits qcr6, qcr7, qcr8, qcr9 and probably NCU16844/qcr10 (PubMed:226365, PubMed:6273583, PubMed:18251112, PubMed:6302289). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplexes SCI(1)III(2), SCIII(2)IV(1) and SCIII(2)IV(2) as well as higher order I(x)III(y)IV(z) megacomplexes) (PubMed:17873079, PubMed:19239619).
messages: Mitochondrion inner membrane
messages: Mitochondrion matrix

367110:NCU08568
gene id: 367110:NCU08568
uniprot id: Q7SB27
names: Similarity
messages: Belongs to the Nudix hydrolase family.

367110:NCU00542
gene id: 367110:NCU00542
uniprot id: Q7SCI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

367110:NCU07889
gene id: 367110:NCU07889
uniprot id: Q7SB05
names: Similarity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.

367110:NCU00522
gene id: 367110:NCU00522
uniprot id: Q7SCL5
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

367110:NCU07487
gene id: 367110:NCU07487
uniprot id: Q7SG54
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

367110:NCU01227
gene id: 367110:NCU01227
uniprot id: Q9P727
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

367110:NCU12120
gene id: 367110:NCU12120
uniprot id: V5IKQ2
names: Subcellular Location Annotation
messages: Membrane

367110:NCU05120
gene id: 367110:NCU05120
uniprot id: Q7RYF4
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

367110:NCU03026
gene id: 367110:NCU03026
uniprot id: Q7SGZ0
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.

367110:NCU07044
gene id: 367110:NCU07044
uniprot id: Q7S992
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

367110:NCU09876
gene id: 367110:NCU09876
uniprot id: Q7S238
names: Subcellular Location Annotation
messages: Membrane

367110:NCU02658
gene id: 367110:NCU02658
uniprot id: Q7SH71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

367110:NCU16027
gene id: 367110:NCU16027
uniprot id: Q12635
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element (By similarity).
messages: Mitochondrion inner membrane

367110:NCU04153
gene id: 367110:NCU04153
uniprot id: Q1K7K6
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

367110:NCU08273
gene id: 367110:NCU08273
uniprot id: Q7S8J4
names: Subcellular Location Annotation
messages: Membrane

367110:NCU00876
gene id: 367110:NCU00876
uniprot id: Q7SFF5
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06486
gene id: 367110:NCU06486
uniprot id: Q7RYI8
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.

367110:NCU08977
gene id: 367110:NCU08977
uniprot id: Q7S2Z2
names: Function
names: Similarity
messages: Belongs to the GMC oxidoreductase family.
messages: Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation.

367110:NCU06534
gene id: 367110:NCU06534
uniprot id: Q7S834
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LTN1 family.
messages: Component of the ribosome quality control complex (RQC), composed of the E3 ubiquitin ligase RKR1/LTN1, RQC1 and RQC2, as well as CDC48 and its ubiquitin-binding cofactors associated with the 60S ribosomal subunits.
messages: E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:27385828). Mediates ubiquitination of proteins derived from mRNAs lacking stop codons (non-stop proteins) and other translation arrest products induced by poly-lysine sequences and tandem rare codons (PubMed:27385828). Ubiquitination leads to CDC48 recruitment for extraction and degradation of the incomplete translation product. May indirectly play a role in chromatin function and transcription (By similarity).
messages: Nucleus
messages: The VLRF1 domain mediates binding to the 60S ribosomal subunit.
messages: cytosol

367110:NCU06702
gene id: 367110:NCU06702
uniprot id: Q871R7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DP1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Oligomer.
messages: Required to generate and maintain the structure of the tubular endoplasmic reticulum network and the vacuole. Induces high curvature in membranes and causes membrane tubule formation. Involved in membrane/vesicle trafficking.
messages: The short lumenal loops between transmembrane domains 1 and 2 and between transmembrane domains 3 and 4 may impart a wedge-like configuration, thus deforming membranes.

367110:NCU01975
gene id: 367110:NCU01975
uniprot id: O42636
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CIA30 family.
messages: Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Mitochondrion

367110:NCU09992
gene id: 367110:NCU09992
uniprot id: Q7S134
names: Similarity
messages: Belongs to the peptidase S28 family.

367110:NCU11027
gene id: 367110:NCU11027
uniprot id: V5IP54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family. PreP subfamily.
messages: Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running (By similarity). Preferentially cleaves the N-terminal side of paired basic amino acid residues (By similarity). Also degrades other unstructured peptides (By similarity). May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase.
messages: Mitochondrion intermembrane space
messages: Mitochondrion matrix
messages: Monomer and homodimer; homodimerization is induced by binding of the substrate.

367110:NCU03264
gene id: 367110:NCU03264
uniprot id: V5IQQ8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

367110:NCU06871
gene id: 367110:NCU06871
uniprot id: Q7S0A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 48 family.
messages: Membrane

367110:NCU04791
gene id: 367110:NCU04791
uniprot id: V5IKV0
uniprot id: V5ILX9
uniprot id: V5IN14
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU06138
gene id: 367110:NCU06138
uniprot id: Q7S5F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU08031
gene id: 367110:NCU08031
uniprot id: Q7SAL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP4 family.
messages: Cytoplasm
messages: Nucleus

367110:NCU05611
gene id: 367110:NCU05611
uniprot id: Q7S5V5
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU04323
gene id: 367110:NCU04323
uniprot id: V5IMU0
uniprot id: V5IPL0
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.

367110:NCU06440
gene id: 367110:NCU06440
uniprot id: U9W2Y4
uniprot id: U9WGF5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

367110:NCU08332
gene id: 367110:NCU08332
uniprot id: P87252
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-5A family. Hex1 subfamily.
messages: Cell septum
messages: Forms oligomers (PubMed:11273682, PubMed:10783241). Self-assembles into hexagonal rods (PubMed:10783241, PubMed:12640443).
messages: Impairs plugging of septal pores and leads to the loss of cytoplasm in hyphae severed by lightly drawing a scalpel blade.
messages: Major component of Woronin bodies, fungal-specific organelles that occlude septal pores in order to separate intact from damaged compartments (PubMed:11273682, PubMed:10783241). Hex-1 binds directly or indirectly to the Woronin body tether that in turn is anchored at the rim of the septal pore (PubMed:11273682, PubMed:10783241).

367110:NCU03827
gene id: 367110:NCU03827
uniprot id: Q7S7R6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS9 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Mitochondrion

367110:NCU04584
gene id: 367110:NCU04584
uniprot id: Q872F4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcriptional coactivator PC4 family.
messages: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. Binds single-stranded DNA (By similarity).
messages: Nucleus

367110:NCU08941
gene id: 367110:NCU08941
uniprot id: Q1K6S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

367110:NCU03241
gene id: 367110:NCU03241
uniprot id: Q7SCN0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.
messages: Binds to histones H3 and H4.
messages: Inhibited by both FK506 and rapamycin.
messages: Nucleus
messages: PPIase that acts as a histone chaperone. Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression.

367110:NCU02924
gene id: 367110:NCU02924
uniprot id: Q7SHI0
names: Caution
names: Function
names: Induction
names: Similarity
messages: A recent genetics report associated srdA and its cluster with the biosynthesis of furanocoumarin neurosporin A, a metabolite produced by N.crassa for chemoresistance against predation by arthropod fungivores (PubMed:28485098). However, based on the gene cluster organization and predicted gene functions, this cluster is unlikely to be involved in neurosporin A biosynthesis, but instead produces compounds similar to pyriculol (PubMed:30908040).
messages: Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.
messages: Expression is up-regulated during sexual development (PubMed:19277664). Expression is also up-regulated during confrontation with the arthropod fungivore Drosophila melanogaster (PubMed:28485098).
messages: Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of sordarial, a salicylic aldehyde structurally related to the phytotoxin pyriculol (PubMed:19277664, PubMed:28485098, PubMed:30908040). The most interesting aspect of this pathway is formation of an aromatic product from the highly reducing polyketide synthase srdA (PubMed:30908040). SrdA synthesizes a reduced polyketide chain from one molecule of acetyl-CoA and five molecules of malonyl-CoA (PubMed:30908040). The polyketide chain is then reductively released as an aldehyde (PubMed:30908040). The oxidoreductases srdC, srdD and srdE then oxidize one of the hydroxy groups to facilitate the intramolecular aldol condensation, followed by dehydration to yield a salicylic aldehyde (PubMed:30908040). This aldehyde can undergo facile reduction by endogenous reductases to yield the alcohol 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene (PubMed:30908040). The flavin-dependent srdI counteract against the propensity of the aldehydes to be reduced under physiological conditions and is responsible for reoxidizing 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene back to the salicylic aldehyde (PubMed:30908040). This salicylic aldehyde is then selectively epoxidized by the cupin-domain-containing oxidoreductase srdB to yield the epoxide, which can be hydrolyzed stereoselectively by the hydrolase srdG to give the final product sordarial (PubMed:30908040).

367110:NCU02879
gene id: 367110:NCU02879
uniprot id: Q7SHM5
names: Subcellular Location Annotation
messages: Membrane

367110:NCU02456
gene id: 367110:NCU02456
uniprot id: Q7S450
names: Subcellular Location Annotation
messages: Membrane

367110:NCU00117
gene id: 367110:NCU00117
uniprot id: Q7RYL2
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

367110:NCU03715
gene id: 367110:NCU03715
uniprot id: Q1K7Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

367110:NCU00901
gene id: 367110:NCU00901
uniprot id: Q7RVZ9
names: Similarity
messages: Belongs to the SMC family. RAD50 subfamily.

367110:NCU03803
gene id: 367110:NCU03803
uniprot id: Q1K7G8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU01853
gene id: 367110:NCU01853
uniprot id: Q7SD15
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

367110:NCU05623
gene id: 367110:NCU05623
uniprot id: P59670
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex, at least composed of tim23, tim17, tim50 and tim21. The complex interacts with the tim44 component of the PAM complex (By similarity).
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Mitochondrion inner membrane

367110:NCU08087
gene id: 367110:NCU08087
uniprot id: Q7SGJ7
names: Similarity
messages: Belongs to the glycosyl hydrolase 26 family.

367110:NCU08439
gene id: 367110:NCU08439
uniprot id: Q1K8N7
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03319
gene id: 367110:NCU03319
uniprot id: Q7SEM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU04304
gene id: 367110:NCU04304
uniprot id: P07144
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic mitochondrial porin family.
messages: Consists mainly of membrane-spanning sided beta-sheets.
messages: Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.
messages: Mitochondrion outer membrane

367110:NCU01476
gene id: 367110:NCU01476
uniprot id: Q7RXV5
names: Similarity
messages: Belongs to the putative lipase ROG1 family.

367110:NCU03579
gene id: 367110:NCU03579
uniprot id: Q1K4S7
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.

367110:NCU03799
gene id: 367110:NCU03799
uniprot id: Q1K7H1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SNW family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

367110:NCU00130
gene id: 367110:NCU00130
uniprot id: U9W8B8
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

367110:NCU07698
gene id: 367110:NCU07698
uniprot id: Q7S9K7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Component of the exocyst complex.

367110:NCU04228
gene id: 367110:NCU04228
uniprot id: Q1K6U5
names: Similarity
messages: Belongs to the PhyH family.

367110:NCU02771
gene id: 367110:NCU02771
uniprot id: Q7SE23
names: Similarity
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Homodimer.

367110:NCU01913
gene id: 367110:NCU01913
uniprot id: Q7SH93
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU06464
gene id: 367110:NCU06464
uniprot id: Q7RYV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTP family.
messages: Involved in protein synthesis. Involved in microtubule stabilization (By similarity).
messages: cytoskeleton

367110:NCU02356
gene id: 367110:NCU02356
uniprot id: Q01371
names: Domain
names: Function
names: Induction
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: By blue light.
messages: FMN binds covalently to cysteine after exposure to blue light and is reversed in the dark.
messages: Heterodimer of wc-1 and wc-2.
messages: May function as a transcription factor involved in light regulation. Binds and affects blue light regulation of the al-3 gene. Wc-1 and wc-2 proteins interact via homologous PAS domains, bind to promoters of light regulated genes such as frq, and activate transcription.
messages: Nucleus
messages: The glutamine-rich domain might function in activating gene expression.

367110:NCU16012
gene id: 367110:NCU16012
uniprot id: P05510
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 5 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Mitochondrion inner membrane

367110:NCU07129
gene id: 367110:NCU07129
uniprot id: Q7S6C3
names: Subcellular Location Annotation
messages: Membrane

367110:NCU07726
gene id: 367110:NCU07726
uniprot id: Q7S8R3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCP1 family.
messages: Cytoplasm
messages: Involved in nuclear export, actin cytoskeleton organization and vesicular transport.
messages: Nucleus

367110:NCU04069
gene id: 367110:NCU04069
uniprot id: Q7RZE9
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

367110:NCU04400
gene id: 367110:NCU04400
uniprot id: Q7RZ73
names: Function
names: Similarity
messages: Belongs to the dihydroxyacetone kinase (DAK) family.
messages: Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.

367110:NCU04759
gene id: 367110:NCU04759
uniprot id: P87102
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Facilitates protein transport into the nucleus. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import (By similarity).

367110:NCU07891
gene id: 367110:NCU07891
uniprot id: Q7S885
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

367110:NCU07308
gene id: 367110:NCU07308
uniprot id: V5IMT9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.

367110:NCU07576
gene id: 367110:NCU07576
uniprot id: Q7S116
names: Similarity
messages: Belongs to the taffazin family.

367110:NCU00623
gene id: 367110:NCU00623
uniprot id: Q7SI29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

367110:NCU11278
gene id: 367110:NCU11278
uniprot id: A7UWF5
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

367110:NCU07267
gene id: 367110:NCU07267
uniprot id: Q01358
names: Induction
messages: By blue light.

367110:NCU06713
gene id: 367110:NCU06713
uniprot id: Q1K6X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

367110:NCU09731
gene id: 367110:NCU09731
uniprot id: P52493
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-conjugating enzyme family.
messages: Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation.
messages: Cytoplasm
messages: Nucleus

367110:NCU11012
gene id: 367110:NCU11012
uniprot id: A7UVS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Nucleus

367110:NCU06749
gene id: 367110:NCU06749
uniprot id: Q1K8T6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU06677
gene id: 367110:NCU06677
uniprot id: Q7S7J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS3 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU02786
gene id: 367110:NCU02786
uniprot id: V5IRA9
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate 1-epimerase family.
messages: Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).

367110:NCU08555
gene id: 367110:NCU08555
uniprot id: Q7SBJ6
names: Subcellular Location Annotation
messages: Membrane

367110:NCU01486
gene id: 367110:NCU01486
uniprot id: V5INF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP1/IKA1 family.
messages: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
messages: Cytoplasm
messages: Nucleus

367110:NCU05927
gene id: 367110:NCU05927
uniprot id: Q7S0P6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Mitochondrion inner membrane
messages: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.

367110:NCU00351
gene id: 367110:NCU00351
uniprot id: Q7RZL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRIPT family.
messages: Cytoplasm

367110:NCU02789
gene id: 367110:NCU02789
uniprot id: Q7SD73
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

367110:NCU01657
gene id: 367110:NCU01657
uniprot id: Q1K4Y9
names: Function
names: Subcellular Location Annotation
messages: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
messages: Mitochondrion inner membrane

367110:NCU09770
gene id: 367110:NCU09770
uniprot id: P15937
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyl-CoA hydrolase/transferase family.
messages: Cytoplasm
messages: Required for utilization of acetate.

367110:NCU07710
gene id: 367110:NCU07710
uniprot id: Q7S9J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IML1 family.
messages: Vacuole membrane

367110:NCU05715
gene id: 367110:NCU05715
uniprot id: Q7SB97
uniprot id: U9W4H0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasm
messages: Membrane
messages: Required for vacuolar protein sorting.
messages: The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.

367110:NCU03970
gene id: 367110:NCU03970
uniprot id: Q6M923
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the flavokinase family.
messages: Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.
messages: Zinc or magnesium.

367110:NCU06193
gene id: 367110:NCU06193
uniprot id: Q9P353
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MMM1 family.
messages: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria (By similarity). Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria (PubMed:10982393). The mdm12-mmm-1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The mdm10-mdm12-mmm-1 subcomplex further acts in the TOM40-specific pathway after the action of the mdm12-mmm-1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids (By similarity).
messages: Endoplasmic reticulum membrane
messages: Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of mmm-1, mdm10, mdm12 and mdm34. A mmm-1 homodimer associates with one molecule of mdm12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of mmm-1 and mdm12 generate a continuous hydrophobic tunnel for phospholipid trafficking.
messages: The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.

367110:NCU02955
gene id: 367110:NCU02955
uniprot id: Q7SH14
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Mitochondrion

367110:NCU08825
gene id: 367110:NCU08825
uniprot id: Q7S8Z0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NBP35 and two labile, bridging clusters between subunits of the NBP35-CFD1 heterotetramer.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
messages: Cytoplasm
messages: Heterotetramer of 2 NBP35 and 2 CFD1 chains.

367110:NCU09107
gene id: 367110:NCU09107
uniprot id: Q7S158
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VMA21 family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.

367110:NCU01013
gene id: 367110:NCU01013
uniprot id: Q7S819
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
messages: Homooctamer.

367110:NCU03335
gene id: 367110:NCU03335
uniprot id: Q1K532
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU10004
gene id: 367110:NCU10004
uniprot id: Q7S0N6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
messages: telomere

367110:NCU06315
gene id: 367110:NCU06315
uniprot id: V5IMA3
uniprot id: V5IP13
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

367110:NCU09821
gene id: 367110:NCU09821
uniprot id: Q7SCP6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU02949
gene id: 367110:NCU02949
uniprot id: Q7SHF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YAE1 family.
messages: Cytoplasm
messages: May form a complex with LTO1.
messages: Nucleus
messages: The complex LTO1:YAE1 may function as a target specific adapter that probably recruits apo-RPLI1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation.

367110:NCU09269
gene id: 367110:NCU09269
uniprot id: Q7RVL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. Ran family.
messages: Found in a nuclear export complex with RanGTP, exportin and pre-miRNA (By similarity).
messages: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity).
messages: Nucleus

367110:NCU03854
gene id: 367110:NCU03854
uniprot id: Q7RW80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DTD family.
messages: Cytoplasm

367110:NCU02393
gene id: 367110:NCU02393
uniprot id: V5IKE7
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

367110:NCU00057
gene id: 367110:NCU00057
uniprot id: Q7RW42
names: Similarity
messages: Belongs to the CBP3 family.

367110:NCU05276
gene id: 367110:NCU05276
uniprot id: Q7S8K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Membrane

367110:NCU04593
gene id: 367110:NCU04593
uniprot id: Q7S065
names: Similarity
messages: Belongs to the multicopper oxidase family.

367110:NCU01545
gene id: 367110:NCU01545
uniprot id: Q8WZY7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG8 family.
messages: The C-terminal 5 residues are removed to expose Gly-116 at the C-terminus. The C-terminal Gly is then amidated with phosphatidylethanolamine by an activating system similar to that for ubiquitin.
messages: Ubiquitin-like modifier involved in autophagosomes formation. With cpr-1/atg4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. The apg-6/atg8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.
messages: Vacuole membrane
messages: autophagosome membrane

367110:NCU08668
gene id: 367110:NCU08668
uniprot id: Q7S8W7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF2/ABP1 family.
messages: Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2 (By similarity).
messages: nucleolus

367110:NCU00428
gene id: 367110:NCU00428
uniprot id: Q7RXT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. PIF1 subfamily.
messages: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.
messages: Mitochondrion
messages: Monomer.
messages: Nucleus

367110:NCU16377
gene id: 367110:NCU16377
uniprot id: V5IQX0
names: Similarity
messages: Belongs to the oligoribonuclease family.

367110:NCU07192
gene id: 367110:NCU07192
uniprot id: Q1K5V2
names: Similarity
messages: Belongs to the GOLGA6 family.

367110:NCU08342
gene id: 367110:NCU08342
uniprot id: Q7SGS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity). The CSN complex is involved in the regulation of the circadian clock through its control of the stability of the SCF(FWD1) complex.
messages: Component of the COP9 signalosome (CSN) complex.
messages: Cytoplasm
messages: Nucleus

367110:NCU08993
gene id: 367110:NCU08993
uniprot id: Q7S2X7
names: Similarity
messages: Belongs to the HEATR5 family.

367110:NCU01255
gene id: 367110:NCU01255
uniprot id: F5HC00
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

367110:NCU04124
gene id: 367110:NCU04124
uniprot id: Q1K7M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASP family.
messages: Golgi apparatus membrane
messages: Membrane

367110:NCU07058
gene id: 367110:NCU07058
uniprot id: Q7S5V9
names: Subcellular Location Annotation
messages: nucleolus

367110:NCU03921
gene id: 367110:NCU03921
uniprot id: Q1K5Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

367110:NCU09820
gene id: 367110:NCU09820
uniprot id: Q7SCP7
names: Subcellular Location Annotation
messages: Membrane

367110:NCU01785
gene id: 367110:NCU01785
uniprot id: Q1K4Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
messages: Nucleus

367110:NCU04019
gene id: 367110:NCU04019
uniprot id: Q1K610
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

367110:NCU02394
gene id: 367110:NCU02394
uniprot id: Q7S4P1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXR1 family.
messages: May be involved in protection from oxidative damage.
messages: Mitochondrion

367110:NCU09621
gene id: 367110:NCU09621
uniprot id: Q1K8M4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

367110:NCU08501
gene id: 367110:NCU08501
uniprot id: Q9P4Z1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPL family. TOM1/PTR1 subfamily.
messages: Nucleus
messages: Probable ubiquitin ligase protein, which may be involved in mRNA export. E3 ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. Participates in mRNA export from the nucleus by regulating the transport of hnRNP proteins.

367110:NCU07190
gene id: 367110:NCU07190
uniprot id: Q1K5V3
names: Similarity
messages: Belongs to the glycosyl hydrolase family 6.

367110:NCU07732
gene id: 367110:NCU07732
uniprot id: P22572
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: In eukaryotes this enzyme is synthesized by two pathway-specific (arginine and pyrimidine) under separate control.
messages: Mitochondrion matrix

367110:NCU05782
gene id: 367110:NCU05782
uniprot id: Q7S5R1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs (By similarity).
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

367110:NCU10282
gene id: 367110:NCU10282
uniprot id: A7UW66
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

367110:NCU05882
gene id: 367110:NCU05882
uniprot id: Q7S526
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

367110:NCU02631
gene id: 367110:NCU02631
uniprot id: Q7SDH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Component of the GINS complex which is a heterotetramer of div-26/sld5, drc-1/psf1, drc-2/psf2 and drc-3/psf3.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

367110:NCU02451
gene id: 367110:NCU02451
uniprot id: Q7S455
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the respiratory chain complex III/complex IV supercomplex.
messages: Belongs to the RCF1 family.
messages: Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.
messages: Mitochondrion membrane

367110:NCU02127
gene id: 367110:NCU02127
uniprot id: Q7SE48
names: Similarity
messages: Belongs to the AccD/PCCB family.

367110:NCU16790
gene id: 367110:NCU16790
uniprot id: V5IND2
names: Similarity
messages: Belongs to the CDC73 family.

367110:NCU00701
gene id: 367110:NCU00701
uniprot id: Q7SEU4
names: Similarity
messages: Belongs to the glycosyl hydrolase 25 family.

367110:NCU05960
gene id: 367110:NCU05960
uniprot id: Q7S1W1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Membrane

367110:NCU09746
gene id: 367110:NCU09746
uniprot id: V5IM07
uniprot id: V5IMB4
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
messages: In the C-terminal section; belongs to the MoeA family.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

367110:NCU03345
gene id: 367110:NCU03345
uniprot id: Q1K524
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus inner membrane

367110:NCU09993
gene id: 367110:NCU09993
uniprot id: Q7S133
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.
messages: Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling.
messages: Component of the SWR1 chromatin-remodeling complex.
messages: Nucleus

367110:NCU00417
gene id: 367110:NCU00417
uniprot id: Q7RYP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

367110:NCU02826
gene id: 367110:NCU02826
uniprot id: Q7RUV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Membrane

367110:NCU09345
gene id: 367110:NCU09345
uniprot id: A7UXC1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NMT1/THI5 family.
messages: Homodimer.
messages: Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.

367110:NCU03857
gene id: 367110:NCU03857
uniprot id: V5ILI1
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

367110:NCU04801
gene id: 367110:NCU04801
uniprot id: Q7S6N4
names: Similarity
messages: Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.

367110:NCU05895
gene id: 367110:NCU05895
uniprot id: Q7S513
names: Subcellular Location Annotation
messages: Membrane

367110:NCU07159
gene id: 367110:NCU07159
uniprot id: Q1K5X6
names: Similarity
messages: Belongs to the peptidase S8 family.

367110:NCU08276
gene id: 367110:NCU08276
uniprot id: Q7S8J1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Endoplasmic reticulum membrane
messages: Inhibited by organophosphorus esters.
messages: Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).

367110:NCU06776
gene id: 367110:NCU06776
uniprot id: Q1K8Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDC1 family.
messages: Membrane
messages: Nucleus membrane
messages: nuclear pore complex

367110:NCU07915
gene id: 367110:NCU07915
uniprot id: Q7SA03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

367110:NCU09547
gene id: 367110:NCU09547
uniprot id: Q7S2B4
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU06558
gene id: 367110:NCU06558
uniprot id: Q1K8F1
names: Similarity
messages: Belongs to the DAMOX/DASOX family.

367110:NCU00523
gene id: 367110:NCU00523
uniprot id: Q7SCL4
names: Cofactor
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.

367110:NCU03246
gene id: 367110:NCU03246
uniprot id: Q7SCM5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

367110:NCU02357
gene id: 367110:NCU02357
uniprot id: Q7S4W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MET18/MMS19 family.
messages: Nucleus
messages: cytoskeleton

367110:NCU00168
gene id: 367110:NCU00168
uniprot id: Q7RXP0
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

367110:NCU09996
gene id: 367110:NCU09996
uniprot id: Q7S057
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-H/MCM16 family.
messages: Nucleus
messages: kinetochore

367110:NCU04269
gene id: 367110:NCU04269
uniprot id: V5INF9
names: Similarity
messages: Belongs to the peptidase A1 family.

367110:NCU07046
gene id: 367110:NCU07046
uniprot id: Q7S990
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

367110:NCU09596
gene id: 367110:NCU09596
uniprot id: Q1K8H1
names: Similarity
messages: Belongs to the PhyH family.

367110:NCU03525
gene id: 367110:NCU03525
uniprot id: Q1K5E4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU03657
gene id: 367110:NCU03657
uniprot id: V5IM04
uniprot id: V5INU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 63 family.
messages: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
messages: Endoplasmic reticulum membrane

367110:NCU05756
gene id: 367110:NCU05756
uniprot id: Q7S4R6
names: Similarity
messages: Belongs to the peptidase M4 family.

367110:NCU08435
gene id: 367110:NCU08435
uniprot id: Q1K8P0
names: Similarity
messages: Belongs to the RdRP family.

367110:NCU17270
gene id: 367110:NCU17270
uniprot id: V5ILQ4
names: Similarity
messages: Belongs to the ustYa family.

367110:NCU07887
gene id: 367110:NCU07887
uniprot id: Q9C167
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Heterodimer of a large and a small subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

367110:NCU04606
gene id: 367110:NCU04606
uniprot id: V5IL21
uniprot id: V5ILA1
names: Similarity
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the crooked-neck family.

367110:NCU05608
gene id: 367110:NCU05608
uniprot id: Q7S6V7
names: Function
names: Similarity
names: Subunit
messages: Associates with DNA double-strand breaks.
messages: Belongs to the PI3/PI4-kinase family.
messages: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.

367110:NCU00641
gene id: 367110:NCU00641
uniprot id: Q7SI11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX16 family.
messages: Mitochondrion inner membrane
messages: Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines.

367110:NCU07837
gene id: 367110:NCU07837
uniprot id: Q7SBC8
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU01250
gene id: 367110:NCU01250
uniprot id: F5HGY4
names: Subcellular Location Annotation
messages: Membrane

367110:NCU04554
gene id: 367110:NCU04554
uniprot id: Q7RWD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.
messages: Secreted

367110:NCU05278
gene id: 367110:NCU05278
uniprot id: Q7S8K7
names: Similarity
messages: Belongs to the cytochrome P450 family.

367110:NCU03566
gene id: 367110:NCU03566
uniprot id: V5IPN7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU07697
gene id: 367110:NCU07697
uniprot id: Q7S9K8
names: Similarity
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Octamer of two non-identical subunits IDH1 and IDH2.

367110:NCU08769
gene id: 367110:NCU08769
uniprot id: P34762
names: Developmental Stage
names: Function
names: Similarity
messages: Belongs to the UPF0654 (con-6) family.
messages: May protect dormant spores from desiccation and play a significant role in the formation or survival of microconidia and ascospores.
messages: Within 2 hours following conidial germination its level decreases rapidly and by 16 hours it is undetectable. Accumulates during the late stages of conidiation and is present in free conidia.

367110:NCU01056
gene id: 367110:NCU01056
uniprot id: Q1K8B1
names: Similarity
messages: Belongs to the Gfa family.

367110:NCU05217
gene id: 367110:NCU05217
uniprot id: Q7S9B7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the REXO4 family.
messages: Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs (By similarity).
messages: Nucleus

367110:NCU01456
gene id: 367110:NCU01456
uniprot id: V5IMN8
uniprot id: V5INA0
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03350
gene id: 367110:NCU03350
uniprot id: Q7RXE4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the xanthine dehydrogenase family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Binds 2 [2Fe-2S] clusters.
messages: Peroxisome

367110:NCU09320
gene id: 367110:NCU09320
uniprot id: Q7SDF1
names: Similarity
messages: Belongs to the ATP phosphoribosyltransferase family.

367110:NCU07993
gene id: 367110:NCU07993
uniprot id: Q7SAP7
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

367110:NCU01258
gene id: 367110:NCU01258
uniprot id: Q871Z4
uniprot id: V5IMX5
names: Function
names: Similarity
messages: Belongs to the cyanase family.
messages: Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.

367110:NCU00712
gene id: 367110:NCU00712
uniprot id: Q7SET4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMG-CoA reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU07765
gene id: 367110:NCU07765
uniprot id: Q7S106
names: Similarity
messages: Belongs to the asaB hydroxylase/desaturase family.

367110:NCU03778
gene id: 367110:NCU03778
uniprot id: Q1K7A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: cytosol

367110:NCU04537
gene id: 367110:NCU04537
uniprot id: Q7RWH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU16891
gene id: 367110:NCU16891
uniprot id: V5IP25
names: Subcellular Location Annotation
messages: Mitochondrion

367110:NCU00125
gene id: 367110:NCU00125
uniprot id: U9W327
uniprot id: U9W373
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WHI5/NRM1 family.
messages: Cytoplasm
messages: Nucleus

367110:NCU07679
gene id: 367110:NCU07679
uniprot id: Q7S9M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC2 subfamily.
messages: Nucleus

367110:NCU02291
gene id: 367110:NCU02291
uniprot id: Q7S579
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

367110:NCU06436
gene id: 367110:NCU06436
uniprot id: Q7RYY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).
messages: Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by atg15 is critical to life span extension (By similarity).
messages: Prevacuolar compartment membrane
messages: multivesicular body membrane

367110:NCU06663
gene id: 367110:NCU06663
uniprot id: Q871U9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts in the GPI biosynthetic pathway between GlcNAc-PI synthesis and GPI transfer to protein.
messages: Belongs to the PIGF family.
messages: Endoplasmic reticulum membrane

367110:NCU07793
gene id: 367110:NCU07793
uniprot id: Q1K636
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

367110:NCU07446
gene id: 367110:NCU07446
uniprot id: Q01278
uniprot id: V5INR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase E subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).
messages: Vacuole membrane

367110:NCU11053
gene id: 367110:NCU11053
uniprot id: A7UXB9
names: Similarity
messages: Belongs to the proteasome subunit p27 family.

367110:NCU03291
gene id: 367110:NCU03291
uniprot id: Q7SDW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

367110:NCU05830
gene id: 367110:NCU05830
uniprot id: Q7S5L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

367110:NCU05250
gene id: 367110:NCU05250
uniprot id: Q7S893
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC2/Nipped-B family.
messages: Nucleus

367110:NCU11085
gene id: 367110:NCU11085
uniprot id: A7UW60
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

367110:NCU10733
gene id: 367110:NCU10733
uniprot id: P0C581
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. PAN2 subfamily.
messages: Binds 2 metal cations per subunit in the catalytic exonuclease domain.
messages: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pabp-1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by rgb-30/xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.
messages: Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.
messages: Cytoplasm
messages: Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit par-2/pan3 to form the poly(A)-nuclease (PAN) deadenylation complex.
messages: Positively regulated by the regulatory subunit par-2/pan3.
messages: The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with par-2/pan3.

367110:NCU04770
gene id: 367110:NCU04770
uniprot id: Q7RVB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

367110:NCU06999
gene id: 367110:NCU06999
uniprot id: V5IMN0
uniprot id: V5IMX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YSP2 family.
messages: Membrane

367110:NCU08856
gene id: 367110:NCU08856
uniprot id: Q1K733
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myo-inositol oxygenase family.
messages: Binds 2 iron ions per subunit.
messages: Cytoplasm

367110:NCU02783
gene id: 367110:NCU02783
uniprot id: Q7SE11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

367110:NCU03819
gene id: 367110:NCU03819
uniprot id: Q9HEC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC16 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy (By similarity).

367110:NCU17257
gene id: 367110:NCU17257
uniprot id: V5IKH2
names: Subcellular Location Annotation
messages: Membrane

367110:NCU09219
gene id: 367110:NCU09219
uniprot id: Q7S3A1
names: Similarity
messages: Belongs to the dopey family.

367110:NCU04117
gene id: 367110:NCU04117
uniprot id: F5HH04
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06301
gene id: 367110:NCU06301
uniprot id: Q7SAC9
names: Similarity
messages: Belongs to the Gfa family.

367110:NCU02240
gene id: 367110:NCU02240
uniprot id: Q7S439
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 61 family.
messages: Secreted

367110:NCU06471
gene id: 367110:NCU06471
uniprot id: Q12641
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

367110:NCU04391
gene id: 367110:NCU04391
uniprot id: Q7RZ82
names: Subcellular Location Annotation
messages: Membrane

367110:NCU09186
gene id: 367110:NCU09186
uniprot id: Q7S329
names: Similarity
messages: Belongs to the trichothecene O-acetyltransferase family.

367110:NCU07690
gene id: 367110:NCU07690
uniprot id: Q7S830
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

367110:NCU09688
gene id: 367110:NCU09688
uniprot id: Q7RVT3
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

367110:NCU04181
gene id: 367110:NCU04181
uniprot id: V5ILY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

367110:NCU07393
gene id: 367110:NCU07393
uniprot id: Q7S1M1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP14 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
messages: nucleolus

367110:NCU00150
gene id: 367110:NCU00150
uniprot id: Q7RXQ8
uniprot id: U9W8C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

367110:NCU06132
gene id: 367110:NCU06132
uniprot id: Q7S5F6
names: Subcellular Location Annotation
messages: Membrane

367110:NCU02430
gene id: 367110:NCU02430
uniprot id: P38675
names: Function
names: Similarity
names: Subunit
messages: Belongs to the trans-sulfuration enzymes family. MET7 subfamily.
messages: Both met-3 and met-7 are required to form a functional cystathionine gamma-synthase.
messages: Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia (By similarity).

367110:NCU06192
gene id: 367110:NCU06192
uniprot id: Q7SBI0
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

367110:NCU00894
gene id: 367110:NCU00894
uniprot id: Q7SFD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

367110:NCU10239
gene id: 367110:NCU10239
uniprot id: A7UW67
names: Subcellular Location Annotation
messages: Membrane

367110:NCU07343
gene id: 367110:NCU07343
uniprot id: V5IMH8
uniprot id: V5IMS8
names: Subcellular Location Annotation
messages: Membrane

367110:NCU01635
gene id: 367110:NCU01635
uniprot id: P07041
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylation of histone H3 leads to transcriptional activation. H3K14ac formation by gcn-5 is promoted by H3S10ph. H3K14ac can also be formed by esa-1. H3K56ac formation occurs predominantly in newly synthesized H3 molecules during G1, S and G2/M of the cell cycle and may be involved in DNA repair (By similarity).
messages: Belongs to the histone H3 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Mono-, di- and trimethylated by the COMPASS complex to form H3K4me1/2/3. H3K4me activates gene expression by regulating transcription elongation and plays a role in telomere length maintenance. H3K4me enrichment correlates with transcription levels, and occurs in a 5' to 3' gradient with H3K4me3 enrichment at the 5'-end of genes, shifting to H3K4me2 and then H3K4me1. Trimethylated by methyltransferase dim-5 to form H3K9me3. H3K9me3, but not H3K9me2, marks chromatin regions for cytosine methylation. Methylated by set-2 to form H3K36me. H3K36me represses gene expression. Methylated by dot-1 to form H3K79me. H3K79me is required for association of SIR proteins with telomeric regions and for telomeric silencing. The COMPASS-mediated formation of H3K4me2/3 and the dot-1-mediated formation of H3K79me require H2BK123ub1 (By similarity).
messages: Nucleus
messages: Phosphorylated to form H3S10ph. H3S10ph promotes subsequent H3K14ac formation and is required for transcriptional activation through TBP recruitment to the promoters (By similarity).
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H3K4me1/2/3 = mono-, di- and trimethylated Lys-5; H3K9ac = acetylated Lys-10; H3K9me3 = trimethylated Lys-10; H3S10ph = phosphorylated Ser-11; H3K14ac = acetylated Lys-15; H3K14me2 = dimethylated Lys-15; H3K18ac = acetylated Lys-19; H3K18me1 = monomethylated Lys-19; H3K23ac = acetylated Lys-24; H3K23me1 = monomethylated Lys-24; H3K27ac = acetylated Lys-28; H3K27me1/2/3 = mono-, di- and trimethylated Lys-28; H3K36ac = acetylated Lys-37; H3K36me1/2/3 = mono-, di- and trimethylated Lys-37; H3K56ac = acetylated Lys-57; H3K64ac = acetylated Lys-65; H3K79me1/2/3 = mono-, di- and trimethylated Lys-80.

367110:NCU00188
gene id: 367110:NCU00188
uniprot id: Q7RX99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a ternary complex with ATG13 and ATG17.
messages: Preautophagosomal structure membrane
messages: Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates. Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9. Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8.

367110:NCU03530
gene id: 367110:NCU03530
uniprot id: Q1K5D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBT5 family.
messages: Membrane

367110:NCU02227
gene id: 367110:NCU02227
uniprot id: Q7S4G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Secreted

367110:NCU02610
gene id: 367110:NCU02610
uniprot id: V5IRH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
messages: Belongs to the dynein light chain family.
messages: Cytoplasmic dynein consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).
messages: cytoskeleton
messages: nuclear pore complex

367110:NCU04144
gene id: 367110:NCU04144
uniprot id: Q1K7L3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Sterol O-acyltransferase that catalyzes the formation of stery esters.

367110:NCU02324
gene id: 367110:NCU02324
uniprot id: Q7S4U0
names: Similarity
messages: Belongs to the FYV7 family.

367110:NCU03461
gene id: 367110:NCU03461
uniprot id: Q7RWJ4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

367110:NCU00536
gene id: 367110:NCU00536
uniprot id: Q7SDK8
names: Similarity
messages: Belongs to the AB hydrolase superfamily. MetX family.

367110:NCU00732
gene id: 367110:NCU00732
uniprot id: Q7SEE6
names: Similarity
messages: Belongs to the cytochrome P450 family.

367110:NCU01868
gene id: 367110:NCU01868
uniprot id: Q7SHD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU05853
gene id: 367110:NCU05853
uniprot id: Q7S555
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

367110:NCU09406
gene id: 367110:NCU09406
uniprot id: Q7S286
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

367110:NCU01776
gene id: 367110:NCU01776
uniprot id: Q8X034
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Component of the large ribosomal subunit (LSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

367110:NCU00251
gene id: 367110:NCU00251
uniprot id: Q7RZW0
names: Similarity
messages: Belongs to the peptidase C2 family. PalB/RIM13 subfamily.

367110:NCU08004
gene id: 367110:NCU08004
uniprot id: Q7RVY2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

367110:NCU06205
gene id: 367110:NCU06205
uniprot id: P78706
names: Disruption Phenotype
names: Function
messages: Mutant are aconidial, female sterile, have reduced growth rates and form hyphae that coil in a counterclockwise direction, opposite to that of the wild-type.
messages: Represses transcription by RNA polymerase II. May be involved at several stages of conidiation and other growth and development processes. Appears to regulate genes that are expressed in asexual and sexual spore pathways.

367110:NCU06569
gene id: 367110:NCU06569
uniprot id: Q7S9G9
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

367110:NCU03526
gene id: 367110:NCU03526
uniprot id: V5IMY0
uniprot id: V5IPP2
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

367110:NCU02712
gene id: 367110:NCU02712
uniprot id: Q7SH17
names: Similarity
messages: Belongs to the acetokinase family.

367110:NCU03914
gene id: 367110:NCU03914
uniprot id: Q1K5Z7
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

367110:NCU00651
gene id: 367110:NCU00651
uniprot id: Q7SI01
names: Caution
names: Similarity
messages: Although strongly related to the peptide:N-glycanase enzyme, it lacks the conserved active site Cys in position 208, which is replaced by a Ala residue suggesting that it has no activity.
messages: Belongs to the transglutaminase-like superfamily. PNGase family.

367110:NCU07242
gene id: 367110:NCU07242
uniprot id: Q7RWA4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU03991
gene id: 367110:NCU03991
uniprot id: Q7RXJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Sterol O-acyltransferase that catalyzes the formation of stery esters.

367110:NCU02498
gene id: 367110:NCU02498
uniprot id: Q7SG66
names: Similarity
messages: Belongs to the cullin family.

367110:NCU04261
gene id: 367110:NCU04261
uniprot id: Q1K7I5
names: Function
names: Similarity
messages: Belongs to the MUB1/samB family.
messages: Involved in determination of the onset of polarized growth and morphogenesis. Plays a role in the regulation of branching in hyphae and spore formation.

367110:NCU04315
gene id: 367110:NCU04315
uniprot id: Q871G3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex cfd1-nbp35. Electrons are transferred to dre2 from NADPH via the FAD- and FMN-containing protein tah18. Tah18-dre2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit rnr2.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: Monomer. Interacts with tah18. Interacts with mia40.
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial mia40-erv1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

367110:NCU06210
gene id: 367110:NCU06210
uniprot id: Q7SBB3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL28 family.

367110:NCU06352
gene id: 367110:NCU06352
uniprot id: Q7S9V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

367110:NCU03085
gene id: 367110:NCU03085
uniprot id: V5IPF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

367110:NCU16596
gene id: 367110:NCU16596
uniprot id: V5IPR7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU04699
gene id: 367110:NCU04699
uniprot id: Q7S5W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
messages: Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).
messages: Endoplasmic reticulum membrane
messages: Mitochondrion membrane

367110:NCU03283
gene id: 367110:NCU03283
uniprot id: V5IR23
names: Similarity
messages: Belongs to the FAH family.

367110:NCU00008
gene id: 367110:NCU00008
uniprot id: Q7RY97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingosine N-acyltransferase family.
messages: Membrane

367110:NCU04320
gene id: 367110:NCU04320
uniprot id: Q7S7L0
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU16017
gene id: 367110:NCU16017
uniprot id: Q35142
names: Subcellular Location Annotation
messages: Mitochondrion membrane

367110:NCU06961
gene id: 367110:NCU06961
uniprot id: Q7SAI8
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

367110:NCU02778
gene id: 367110:NCU02778
uniprot id: Q7SE16
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

367110:NCU06397
gene id: 367110:NCU06397
uniprot id: V5IQ46
names: Function
names: Similarity
names: Subunit
messages: Belongs to the profilin family.
messages: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.
messages: Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

367110:NCU01272
gene id: 367110:NCU01272
uniprot id: Q7S7C0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family. PreP subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running (By similarity). Preferentially cleaves the N-terminal side of paired basic amino acid residues (By similarity). Also degrades other unstructured peptides (By similarity). May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase (By similarity).
messages: Mitochondrion intermembrane space
messages: Mitochondrion matrix
messages: Monomer and homodimer; homodimerization is induced by binding of the substrate.

367110:NCU06395
gene id: 367110:NCU06395
uniprot id: Q7S9F2
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU00195
gene id: 367110:NCU00195
uniprot id: Q7RX92
names: Subcellular Location Annotation
messages: Membrane

367110:NCU02074
gene id: 367110:NCU02074
uniprot id: Q7SEY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane
messages: Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly pdi1 isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on pdi1 to transfer oxidizing equivalent. Does not oxidize all pdi related proteins, suggesting that it can discriminate between pdi1 and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress (By similarity).
messages: May function both as a monomer and a homodimer.

367110:NCU04189
gene id: 367110:NCU04189
uniprot id: P38678
names: Caution
names: Function
names: Similarity
messages: Belongs to the KNR4/SMI1 family.
messages: Involved in the regulation of 1,3-beta-glucan synthase activity and cell-wall formation.
messages: Was originally thought to be a glucan synthase.

367110:NCU06780
gene id: 367110:NCU06780
uniprot id: Q1K8Z0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

367110:NCU10046
gene id: 367110:NCU10046
uniprot id: Q7S086
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

367110:NCU04158
gene id: 367110:NCU04158
uniprot id: P23762
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NmrA-type oxidoreductase family.
messages: Interacts with nit-2.
messages: Lacks the conserved Tyr residue in position 211 in the active site triad of Ser-Tyr-Lys necessary for dehydrogenase activity, suggesting that it has no oxidoreductase activity.
messages: May be a redox sensor protein. Negative transcriptional regulator involved in the post-transcriptional modulation of the GATA-type transcription factor nit-2, forming part of a system controlling nitrogen metabolite repression (By similarity).
messages: Nucleus

367110:NCU02665
gene id: 367110:NCU02665
uniprot id: Q7SH64
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

367110:NCU03787
gene id: 367110:NCU03787
uniprot id: V5IM45
uniprot id: V5IMR5
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU10034
gene id: 367110:NCU10034
uniprot id: Q7S0A1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WRB/GET1 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with GET3.
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.

367110:NCU07001
gene id: 367110:NCU07001
uniprot id: Q1K8F9
names: Similarity
messages: Belongs to the AB hydrolase superfamily. MetX family.

367110:NCU05000
gene id: 367110:NCU05000
uniprot id: Q7RW48
names: Domain
names: Function
names: Similarity
messages: Belongs to the adenylate-forming reductase family.
messages: Carboxylic acid reductase that shows a broad range of substrate specificity towards aromatic acids, especially to phenyl carboxylic and phenyl acrylic acids, to convert them into their respective aldehydes (PubMed:4389863, PubMed:11946054, PubMed:27917101, PubMed:29515539). Also able to use aliphatic acids as substrates (PubMed:29515539).
messages: The NRPS-like carboxylic acid reductase (CAR) has an unusual domain architecture (A-T-R), with the adenylation domain A activating and thioesterifying the carboxylic acid which is then channeled through the phosphopantetheine arm of the T domain, the thioester reductase domain R reducing the carboxylic acid to the corresponding aldehyde.

367110:NCU04050
gene id: 367110:NCU04050
uniprot id: P11115
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family. GCN4 subfamily.
messages: Binds DNA as a dimer.
messages: In N.crassa grown under amino acid starvation conditions, this protein is required for increasing the transcription of the genes coding for many amino acid biosynthetic pathways enzymes. This transcription factor binds and recognize the DNA sequence: 5'-TGACTC-3'.
messages: Nucleus

367110:NCU07437
gene id: 367110:NCU07437
uniprot id: Q7SF16
names: Similarity
messages: Belongs to the eIF-1A family.

367110:NCU04814
gene id: 367110:NCU04814
uniprot id: Q7S6M1
names: Subcellular Location Annotation
messages: Membrane

367110:NCU05224
gene id: 367110:NCU05224
uniprot id: Q7S8I3
names: Similarity
messages: Belongs to the uridine kinase family.

367110:NCU10049
gene id: 367110:NCU10049
uniprot id: Q7S083
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG12 family.
messages: Forms a conjugate with apg-4/atg5.
messages: Preautophagosomal structure membrane
messages: Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with apg-4/atg5 through a ubiquitin-like conjugating system involving also apg-5/atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-apg-4/atg5 conjugate functions as an E3-like enzyme which is required for lipidation of apg-6/atg8 and apg-6/atg8 association to the vesicle membranes (By similarity).

367110:NCU11046
gene id: 367110:NCU11046
uniprot id: V5IL74
uniprot id: V5INN4
names: Similarity
messages: Belongs to the chloroperoxidase family.

367110:NCU04657
gene id: 367110:NCU04657
uniprot id: Q7S3B7
names: Similarity
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

367110:NCU08552
gene id: 367110:NCU08552
uniprot id: Q7SBJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU02052
gene id: 367110:NCU02052
uniprot id: V5IP24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF2 family.
messages: Nucleus

367110:NCU01184
gene id: 367110:NCU01184
uniprot id: Q1K852
names: Similarity
messages: Belongs to the RRM CWC2 family.

367110:NCU01103
gene id: 367110:NCU01103
uniprot id: Q1K876
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

367110:NCU08879
gene id: 367110:NCU08879
uniprot id: Q7S757
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU00644
gene id: 367110:NCU00644
uniprot id: Q7SI08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane

367110:NCU02558
gene id: 367110:NCU02558
uniprot id: Q7SHQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MEF2 family.
messages: Nucleus

367110:NCU02337
gene id: 367110:NCU02337
uniprot id: Q7S4S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

367110:NCU02201
gene id: 367110:NCU02201
uniprot id: Q7S4C0
names: Similarity
messages: Belongs to the multicopper oxidase family.

367110:NCU07347
gene id: 367110:NCU07347
uniprot id: V5IQX1
uniprot id: V5IRN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 17 family.
messages: cell wall

367110:NCU11185
gene id: 367110:NCU11185
uniprot id: U9W3E6
uniprot id: U9W3J8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

367110:NCU09575
gene id: 367110:NCU09575
uniprot id: Q7S4M5
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

367110:NCU09374
gene id: 367110:NCU09374
uniprot id: Q7SCN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor potential (TRP) ion channel family.
messages: Membrane

367110:NCU09068
gene id: 367110:NCU09068
uniprot id: P19212
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: By lack of a primary nitrogen source.
messages: Interacts with nmr.
messages: Major nitrogen regulatory protein. During conditions of nitrogen limitation it turns on the expression of genes for enzymes which are required for the use of a variety of secondary nitrogen sources, including nitrates, purines, amino acids, and proteins.
messages: Nucleus

367110:NCU00157
gene id: 367110:NCU00157
uniprot id: Q7RXQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN1 family.
messages: Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity). The CSN complex is involved in the regulation of the circadian clock through its control of the stability of the SCF(FWD-1) complex.
messages: Component of the COP9 signalosome (CSN) complex.
messages: Cytoplasm
messages: Nucleus

367110:NCU05982
gene id: 367110:NCU05982
uniprot id: Q7S214
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Mitochondrion inner membrane
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

367110:NCU02510
gene id: 367110:NCU02510
uniprot id: Q7SHV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

367110:NCU07507
gene id: 367110:NCU07507
uniprot id: V5IPV8
names: Similarity
messages: Belongs to the complex I LYR family. SDHAF1 subfamily.

367110:NCU05185
gene id: 367110:NCU05185
uniprot id: Q7S8E0
names: Similarity
messages: In the N-terminal section; belongs to the cytochrome P450 family.

367110:NCU03963
gene id: 367110:NCU03963
uniprot id: Q7RZA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus

367110:NCU09253
gene id: 367110:NCU09253
uniprot id: Q7SF57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor potential (TRP) ion channel family.
messages: Membrane

367110:NCU16328
gene id: 367110:NCU16328
uniprot id: V5INT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the C1D family.
messages: Nucleus
messages: Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.

367110:NCU07852
gene id: 367110:NCU07852
uniprot id: Q7SBV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU06673
gene id: 367110:NCU06673
uniprot id: Q7S7J8
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

367110:NCU01786
gene id: 367110:NCU01786
uniprot id: Q1K4Q8
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

367110:NCU07560
gene id: 367110:NCU07560
uniprot id: Q7S1Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL46 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU06367
gene id: 367110:NCU06367
uniprot id: Q7S9T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Membrane

367110:NCU00035
gene id: 367110:NCU00035
uniprot id: U9WGL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Sterol O-acyltransferase that catalyzes the formation of stery esters.

367110:NCU08071
gene id: 367110:NCU08071
uniprot id: P08580
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS16 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Mitochondrion

367110:NCU07991
gene id: 367110:NCU07991
uniprot id: Q7SAP9
names: Similarity
messages: Belongs to the IST1 family.

367110:NCU01428
gene id: 367110:NCU01428
uniprot id: V5ILW6
names: Similarity
names: Subunit
messages: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
messages: Homotetramer.

367110:NCU00648
gene id: 367110:NCU00648
uniprot id: Q7SI04
names: Subcellular Location Annotation
messages: Membrane

367110:NCU07919
gene id: 367110:NCU07919
uniprot id: Q7S9Z9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

367110:NCU07156
gene id: 367110:NCU07156
uniprot id: Q1K5X9
names: Function
names: Similarity
messages: Belongs to the HisA/HisF family.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.
messages: In the C-terminal section; belongs to the HisA/HisF family.

367110:NCU10897
gene id: 367110:NCU10897
uniprot id: A7UWS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex DAD4 family.
messages: Nucleus
messages: kinetochore
messages: spindle

367110:NCU09598
gene id: 367110:NCU09598
uniprot id: Q873L8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YME2 family.
messages: Mitochondrion inner membrane
messages: Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA (By similarity).

367110:NCU07383
gene id: 367110:NCU07383
uniprot id: Q7S2H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGG1 family.
messages: Nucleus

367110:NCU03588
gene id: 367110:NCU03588
uniprot id: Q7S773
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU01981
gene id: 367110:NCU01981
uniprot id: Q7SE79
names: Similarity
messages: Belongs to the SUI1 family.

367110:NCU06993
gene id: 367110:NCU06993
uniprot id: Q7SAF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSH4 family.
messages: Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane.
messages: Endosome membrane
messages: Membrane
messages: Vacuole membrane

367110:NCU04927
gene id: 367110:NCU04927
uniprot id: Q7S3U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WHI5/NRM1 family.
messages: Cytoplasm
messages: Nucleus

367110:NCU11180
gene id: 367110:NCU11180
uniprot id: P0C584
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PLPL family.
messages: Membrane
messages: Probable lipid hydrolase.

367110:NCU06559
gene id: 367110:NCU06559
uniprot id: Q1K8F0
names: Similarity
messages: Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.

367110:NCU02168
gene id: 367110:NCU02168
uniprot id: Q7SEP9
names: Subcellular Location Annotation
messages: Membrane

367110:NCU08114
gene id: 367110:NCU08114
uniprot id: Q7SD12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU00925
gene id: 367110:NCU00925
uniprot id: Q7SFC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pescadillo family.
messages: Component of the NOP7 complex, composed of erb1, nop7 and ytm1. The complex is held together by erb1, which interacts with nop7 via its N-terminal domain and with ytm1 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome.
messages: Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

367110:NCU06542
gene id: 367110:NCU06542
uniprot id: Q7S9I4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins. uS12m forms part of the decoding center of the mt-SSU.
messages: Mitochondrion

367110:NCU06396
gene id: 367110:NCU06396
uniprot id: Q7S9F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: Membrane

367110:NCU04251
gene id: 367110:NCU04251
uniprot id: P30588
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chitin synthase family.
messages: Cell membrane
messages: Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.

367110:NCU00121
gene id: 367110:NCU00121
uniprot id: Q7RYK8
names: Subcellular Location Annotation
messages: Membrane

367110:NCU00112
gene id: 367110:NCU00112
uniprot id: Q7RYL6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24B family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.

367110:NCU02128
gene id: 367110:NCU02128
uniprot id: V5IP06
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU01221
gene id: 367110:NCU01221
uniprot id: Q9P720
uniprot id: V5ILK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Component of the large ribosomal subunit (LSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

367110:NCU08609
gene id: 367110:NCU08609
uniprot id: Q7SFK9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP3 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the lipid remodeling steps of GPI-anchor maturation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

367110:NCU01120
gene id: 367110:NCU01120
uniprot id: Q1K767
names: Similarity
messages: Belongs to the TOP6A family.

367110:NCU01841
gene id: 367110:NCU01841
uniprot id: Q1K570
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex DAD2 family.
messages: Nucleus
messages: kinetochore
messages: spindle

367110:NCU03000
gene id: 367110:NCU03000
uniprot id: Q7RV41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 61 family.
messages: Secreted

367110:NCU01164
gene id: 367110:NCU01164
uniprot id: Q8X0X6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Although related to the peptidase M24 family, this protein lacks conserved active site residues suggesting that it may lack peptidase activity.
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).
messages: Forms a stable heterodimer with ctc-1/pob3. The dimer of ctc-1 and ctc-2 weakly associates with multiple molecules of nhp-1/nhp6 to form the FACT complex (By similarity).
messages: Nucleus

367110:NCU00463
gene id: 367110:NCU00463
uniprot id: Q7RXY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
messages: Cytoplasm
messages: Homodimer.

367110:NCU00693
gene id: 367110:NCU00693
uniprot id: Q7SHW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP40 family.
messages: Cytoplasm
messages: nucleolus

367110:NCU03383
gene id: 367110:NCU03383
uniprot id: Q1K5G5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KXD1 family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.
messages: Endosome

367110:NCU05924
gene id: 367110:NCU05924
uniprot id: Q7S0Y0
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

367110:NCU04307
gene id: 367110:NCU04307
uniprot id: Q1K726
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

367110:NCU04129
gene id: 367110:NCU04129
uniprot id: Q1K7M3
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

367110:NCU07700
gene id: 367110:NCU07700
uniprot id: Q96X45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

367110:NCU02391
gene id: 367110:NCU02391
uniprot id: Q7S4P3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: The COPII coat is composed of at least 5 proteins: the sec23/24 complex, the sec13/31 complex, and the protein vtr-7/sar1.

367110:NCU02472
gene id: 367110:NCU02472
uniprot id: P21976
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA8 subunit family.
messages: Binds 1 iron-sulfur cluster.
messages: Complex I is composed of about 40 different subunits. This is a component of the hydrophobic fraction.
messages: Mitochondrion inner membrane

367110:NCU01050
gene id: 367110:NCU01050
uniprot id: Q1K8B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 61 family.
messages: Secreted

367110:NCU04654
gene id: 367110:NCU04654
uniprot id: Q1K6G1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit and an accessory subunit.
messages: Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).

367110:NCU04938
gene id: 367110:NCU04938
uniprot id: Q7S3S9
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

367110:NCU06025
gene id: 367110:NCU06025
uniprot id: P11635
names: Function
names: Induction
messages: Expression is induced in the presence of quinic acid (PubMed:144915, PubMed:6458044). The quinic acid (qa) gene cluster is subject to two levels of gene control: a primary system which responds to the presence of quinic acid via the qa-1S repressor protein that blocks the qa-1F activator, and a secondary system which represses transcription of qa genes in the presence of a preferred carbon source such as glucose (PubMed:9279395, PubMed:6458044, PubMed:12477937, PubMed:17597928, PubMed:19236936).
messages: Quinate dehydrogenase; part of the qa gene cluster that mediates the catabolism of quinic acid (QA) and as such, allows the use of QA as a sole carbon source (PubMed:2525625, PubMed:151647, PubMed:6458044). Catalyzes the first reaction in the inducible quinic acid catabolic pathway by converting quinate into 3-dehydroquinate (PubMed:151647). The qa cluster encodes 3 inducible enymes (qa-2, qa-3 and qa-4) catalyzing the first three reactions in the catabolism of quinic acid to protocatechuic acid (also known as 3,4-Dihydroxybenzoic acid) (Probable).

367110:NCU00437
gene id: 367110:NCU00437
uniprot id: Q7RXS2
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.

367110:NCU04768
gene id: 367110:NCU04768
uniprot id: Q7S640
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

367110:NCU05208
gene id: 367110:NCU05208
uniprot id: Q7S9C5
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU00166
gene id: 367110:NCU00166
uniprot id: Q7RXP2
names: Similarity
messages: Belongs to the isochorismatase family.

367110:NCU09556
gene id: 367110:NCU09556
uniprot id: Q7S2A5
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU16560
gene id: 367110:NCU16560
uniprot id: V5IPG1
uniprot id: V5IR29
names: Function
names: Subcellular Location Annotation
messages: RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.
messages: nucleolus

367110:NCU03824
gene id: 367110:NCU03824
uniprot id: Q9HEC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with 90S and pre-40S pre-ribosomal particles.
messages: Belongs to the RRP36 family.
messages: Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway (By similarity).
messages: nucleolus

367110:NCU04041
gene id: 367110:NCU04041
uniprot id: Q7RZH4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
messages: Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

367110:NCU00657
gene id: 367110:NCU00657
uniprot id: Q7SHZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE4 family.
messages: Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
messages: Component of the SMC5-SMC6 complex.
messages: Nucleus

367110:NCU01595
gene id: 367110:NCU01595
uniprot id: F5HCE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DCAF13/WDSOF1 family.
messages: nucleolus

367110:NCU01002
gene id: 367110:NCU01002
uniprot id: Q1K8E3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COPE family.
messages: Cytoplasm
messages: Membrane
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

367110:NCU03374
gene id: 367110:NCU03374
uniprot id: Q7RX18
names: Similarity
messages: Belongs to the ustYa family.

367110:NCU10055
gene id: 367110:NCU10055
uniprot id: Q9UW81
names: Developmental Stage
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal/bacterial/fungal opsin family.
messages: Binds all-trans retinal via a protonated Schiff base linkage.
messages: Could facilitate a sensory photoresponse.
messages: Highest expression in sexually differentiated cultures and conidia when there has been exposure to light. Also expressed during vegetative growth.
messages: Membrane

367110:NCU05233
gene id: 367110:NCU05233
uniprot id: Q7S8H5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP53 family.
messages: May play a role in ribosome biogenesis.
messages: nucleolus
messages: nucleoplasm

367110:NCU05201
gene id: 367110:NCU05201
uniprot id: Q7S9D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

367110:NCU06662
gene id: 367110:NCU06662
uniprot id: Q1K6Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

367110:NCU04611
gene id: 367110:NCU04611
uniprot id: Q8NIV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT6 family.
messages: Nucleus
messages: Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity).

367110:NCU01165
gene id: 367110:NCU01165
uniprot id: Q1K865
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

367110:NCU08940
gene id: 367110:NCU08940
uniprot id: Q871K1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRB/QCR7 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (cob), cytochrome c1 (cyt-1) and Rieske protein (fes-1), 2 core protein subunits pep and ucr-1, and 5 low-molecular weight protein subunits qcr6, qcr7, qcr8, qcr9 and probably NCU16844/qcr10 (PubMed:226365, PubMed:6273583, PubMed:18251112, PubMed:6302289). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplexes SCI(1)III(2), SCIII(2)IV(1) and SCIII(2)IV(2) as well as higher order I(x)III(y)IV(z) megacomplexes) (PubMed:17873079, PubMed:19239619).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Mitochondrion inner membrane

367110:NCU08309
gene id: 367110:NCU08309
uniprot id: V5INX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

367110:NCU04874
gene id: 367110:NCU04874
uniprot id: Q7S371
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alternative oxidase family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.
messages: Mitochondrion inner membrane

367110:NCU09371
gene id: 367110:NCU09371
uniprot id: Q7RVJ3
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

367110:NCU08363
gene id: 367110:NCU08363
uniprot id: Q7SGQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPDU1 (TC 2.A.43.3) family.
messages: Membrane

367110:NCU00939
gene id: 367110:NCU00939
uniprot id: Q7SFA8
names: Similarity
messages: Belongs to the ERT1/acuK family.

367110:NCU03638
gene id: 367110:NCU03638
uniprot id: Q1K7P9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL34 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU07458
gene id: 367110:NCU07458
uniprot id: Q7SD48
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.

367110:NCU08138
gene id: 367110:NCU08138
uniprot id: Q7S3Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

367110:NCU04782
gene id: 367110:NCU04782
uniprot id: Q7S627
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Chromosome

367110:NCU09109
gene id: 367110:NCU09109
uniprot id: Q7S156
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

367110:NCU03310
gene id: 367110:NCU03310
uniprot id: Q7SEN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Mitochondrion inner membrane

367110:NCU01008
gene id: 367110:NCU01008
uniprot id: Q1K8D9
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

367110:NCU09182
gene id: 367110:NCU09182
uniprot id: Q7S333
names: Subunit
messages: Homodimer.

367110:NCU02777
gene id: 367110:NCU02777
uniprot id: Q7SE17
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.
messages: Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.

367110:NCU07318
gene id: 367110:NCU07318
uniprot id: Q7SA44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the mannitol dehydrogenase family.
messages: Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway.
messages: Monomer.

367110:NCU01820
gene id: 367110:NCU01820
uniprot id: Q7RWC2
names: Function
names: Similarity
messages: Belongs to the exportin family.
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.

367110:NCU09511
gene id: 367110:NCU09511
uniprot id: Q7S1Q4
names: Subcellular Location Annotation
messages: Mitochondrion

367110:NCU01475
gene id: 367110:NCU01475
uniprot id: Q6MW04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 19 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

367110:NCU02737
gene id: 367110:NCU02737
uniprot id: Q7SGB2
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

367110:NCU11195
gene id: 367110:NCU11195
uniprot id: A7UVX7
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

367110:NCU07916
gene id: 367110:NCU07916
uniprot id: Q7SA02
names: Similarity
messages: Belongs to the PheA/TfdB FAD monooxygenase family.

367110:NCU04115
gene id: 367110:NCU04115
uniprot id: Q1K7N3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

367110:NCU03650
gene id: 367110:NCU03650
uniprot id: Q1K7P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

367110:NCU02791
gene id: 367110:NCU02791
uniprot id: Q7SD71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reverse transcriptase family. Telomerase subfamily.
messages: Nucleus
messages: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
messages: telomere

367110:NCU07501
gene id: 367110:NCU07501
uniprot id: Q7SG41
names: Similarity
messages: Belongs to the PGA52 family.

367110:NCU01241
gene id: 367110:NCU01241
uniprot id: Q1K816
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

367110:NCU04108
gene id: 367110:NCU04108
uniprot id: Q1K7N8
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

367110:NCU09407
gene id: 367110:NCU09407
uniprot id: Q7S285
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PLPL family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lipid hydrolase.
messages: Membrane
messages: Probable lipid hydrolase.

367110:NCU05809
gene id: 367110:NCU05809
uniprot id: Q7S5N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF8 family.
messages: Nucleus

367110:NCU00227
gene id: 367110:NCU00227
uniprot id: Q7RZY4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

367110:NCU11402
gene id: 367110:NCU11402
uniprot id: A7UXB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU02271
gene id: 367110:NCU02271
uniprot id: Q7S595
names: Similarity
messages: Belongs to the RMD1/sif2 family.

367110:NCU03234
gene id: 367110:NCU03234
uniprot id: Q7SGT6
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

367110:NCU09580
gene id: 367110:NCU09580
uniprot id: Q7S4M0
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03050
gene id: 367110:NCU03050
uniprot id: V5IQ94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Component of the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

367110:NCU02207
gene id: 367110:NCU02207
uniprot id: Q7S465
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

367110:NCU02493
gene id: 367110:NCU02493
uniprot id: Q7SG71
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

367110:NCU04994
gene id: 367110:NCU04994
uniprot id: V5IL52
names: Similarity
messages: Belongs to the peptidase M28 family.

367110:NCU09302
gene id: 367110:NCU09302
uniprot id: Q7S1H9
names: Function
names: Similarity
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes.

367110:NCU04327
gene id: 367110:NCU04327
uniprot id: Q1K713
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Nucleus

367110:NCU02812
gene id: 367110:NCU02812
uniprot id: Q7SEK2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

367110:NCU03836
gene id: 367110:NCU03836
uniprot id: Q7S745
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Component of the EKC/KEOPS complex composed of at least bud32, cgi121, gon7, kae1 and pcc1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
messages: Cytoplasm
messages: Nucleus

367110:NCU09825
gene id: 367110:NCU09825
uniprot id: Q7S1R7
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU08189
gene id: 367110:NCU08189
uniprot id: Q7S3P8
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

367110:NCU07755
gene id: 367110:NCU07755
uniprot id: Q7S1S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

367110:NCU05079
gene id: 367110:NCU05079
uniprot id: Q7RWK5
names: Similarity
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.

367110:NCU11196
gene id: 367110:NCU11196
uniprot id: A7UVX8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU04738
gene id: 367110:NCU04738
uniprot id: Q7S6G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM10 family.
messages: Nucleus

367110:NCU00892
gene id: 367110:NCU00892
uniprot id: O13492
names: Cofactor
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A monovalent cation.
messages: Belongs to the folylpolyglutamate synthase family.
messages: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.
messages: Cytoplasm
messages: Higher transcript levels are detected in freshly germinated mycelium, with less expression seen in ungerminated conidia and cultures near stationary phase.
messages: Mitochondrion inner membrane
messages: Mitochondrion matrix

367110:NCU04697
gene id: 367110:NCU04697
uniprot id: Q7RVT0
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.
messages: By cyanide.
messages: Catalyzes the hydration of cyanide to formamide. Degradation of cyanide may be important for plant pathogenic fungi in infection of cyanogenic plants.
messages: Oligomer of dimers, forming left-handed helical fibers with a diameter of 13 nm but with lengths ranging from approximately 1 um at the leading edge of the peak to having approximately the same length and diameter at the trailing edge.

367110:NCU03641
gene id: 367110:NCU03641
uniprot id: V5IM00
uniprot id: V5IMM3
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

367110:NCU07111
gene id: 367110:NCU07111
uniprot id: Q7S664
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

367110:NCU04344
gene id: 367110:NCU04344
uniprot id: Q7RX32
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

367110:NCU08755
gene id: 367110:NCU08755
uniprot id: Q7RWP2
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

367110:NCU04672
gene id: 367110:NCU04672
uniprot id: V5IL08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

367110:NCU02961
gene id: 367110:NCU02961
uniprot id: Q7SH08
names: Similarity
messages: Belongs to the REXO1/REXO3 family.

367110:NCU03837
gene id: 367110:NCU03837
uniprot id: Q7S744
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.

367110:NCU02475
gene id: 367110:NCU02475
uniprot id: Q7SG89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvP family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

367110:NCU06260
gene id: 367110:NCU06260
uniprot id: Q7SB53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic GTase family.
messages: Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.
messages: Nucleus
messages: Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.

367110:NCU09065
gene id: 367110:NCU09065
uniprot id: Q7SCT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC5 subfamily.
messages: Nucleus

367110:NCU03786
gene id: 367110:NCU03786
uniprot id: Q7S7P2
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

367110:NCU08661
gene id: 367110:NCU08661
uniprot id: Q7S8P2
names: Similarity
messages: Belongs to the pantothenate synthetase family.

367110:NCU06699
gene id: 367110:NCU06699
uniprot id: Q1K739
names: Subcellular Location Annotation
messages: Membrane

367110:NCU05420
gene id: 367110:NCU05420
uniprot id: Q12640
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Bifunctional chorismate synthase and flavin reductase that catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is the last common intermediate in the synthesis of the three aromatic amino acids phenylalanine, tyrosine and tryptophan (PubMed:7657620, PubMed:4146266, PubMed:4155270, PubMed:7947820, PubMed:7819217, PubMed:8971708, PubMed:11034781, PubMed:11526120, PubMed:17326665, PubMed:18279385, PubMed:14668332). Acts also as a flavin reductase (FR) able to generate reduced flavin mononucleotide in the presence of NADPH (PubMed:4146266, PubMed:4155270, PubMed:7947820, PubMed:8971708, PubMed:11526120, PubMed:18279385, PubMed:14668332).
messages: Homotetramer.
messages: NADPH binds in or near the substrate (5-enolpyruvylshikimate 3-phosphate) binding site, suggesting that NADPH binding to bifunctional chorismate synthases is embedded in the general protein structure and a special NADPH binding domain is not required to generate the intrinsic oxidoreductase activity.

367110:NCU07266
gene id: 367110:NCU07266
uniprot id: Q7S949
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diphthine synthase family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

367110:NCU02920
gene id: 367110:NCU02920
uniprot id: Q7SHI4
names: Caution
names: Function
names: Induction
names: Similarity
messages: A recent genetics report associated srdA and its cluster with the biosynthesis of furanocoumarin neurosporin A, a metabolite produced by N.crassa for chemoresistance against predation by arthropod fungivores (PubMed:28485098). However, based on the gene cluster organization and predicted gene functions, this cluster is unlikely to be involved in neurosporin A biosynthesis, but instead produces compounds similar to pyriculol (PubMed:30908040).
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Expression is up-regulated during sexual development (PubMed:19277664). Expression is also up-regulated during confrontation with the arthropod fungivore Drosophila melanogaster (PubMed:28485098).
messages: Short-chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of sordarial, a salicylic aldehyde structurally related to the phytotoxin pyriculol (PubMed:19277664, PubMed:28485098, PubMed:30908040). The most interesting aspect of this pathway is formation of an aromatic product from the highly reducing polyketide synthase srdA (PubMed:30908040). SrdA synthesizes a reduced polyketide chain from one molecule of acetyl-CoA and five molecules of malonyl-CoA (PubMed:30908040). The polyketide chain is then reductively released as an aldehyde (PubMed:30908040). The oxidoreductases srdC, srdD and srdE then oxidize one of the hydroxy groups to facilitate the intramolecular aldol condensation, followed by dehydration to yield a salicylic aldehyde (PubMed:30908040). This aldehyde can undergo facile reduction by endogenous reductases to yield the alcohol 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene (PubMed:30908040). The flavin-dependent srdI counteract against the propensity of the aldehydes to be reduced under physiological conditions and is responsible for reoxidizing 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene back to the salicylic aldehyde (PubMed:30908040). This salicylic aldehyde is then selectively epoxidized by the cupin-domain-containing oxidoreductase srdB to yield the epoxide, which can be hydrolyzed stereoselectively by the hydrolase srdG to give the final product sordarial (PubMed:30908040).

367110:NCU01540
gene id: 367110:NCU01540
uniprot id: Q7RWZ3
names: Subcellular Location Annotation
messages: Membrane

367110:NCU02803
gene id: 367110:NCU02803
uniprot id: Q7SEL0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).
messages: Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.
messages: Component of the U5 snRNP complex.
messages: Cytoplasm
messages: Nucleus
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

367110:NCU03042
gene id: 367110:NCU03042
uniprot id: Q7SDG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B1 family.
messages: Nucleus
messages: cytoskeleton

367110:NCU09427
gene id: 367110:NCU09427
uniprot id: Q7S0B5
names: Subcellular Location Annotation
messages: Membrane

367110:NCU04242
gene id: 367110:NCU04242
uniprot id: Q9HEH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Cytoplasm
messages: RNA-dependent helicase required for nonsense-mediated decay (NMD) of aberrant mRNAs containing premature stop codons and modulates the expression level of normal mRNAs (By similarity). Also capable of unwinding double-stranded DNA and translocating on single-stranded DNA (By similarity).

367110:NCU08894
gene id: 367110:NCU08894
uniprot id: Q1K698
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.

367110:NCU03070
gene id: 367110:NCU03070
uniprot id: V5IPF0
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU10387
gene id: 367110:NCU10387
uniprot id: A7UX00
names: Similarity
messages: Belongs to the FMO family.

367110:NCU05425
gene id: 367110:NCU05425
uniprot id: Q7SC30
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

367110:NCU02249
gene id: 367110:NCU02249
uniprot id: Q7S5B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Chromosome

367110:NCU02983
gene id: 367110:NCU02983
uniprot id: Q1K945
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the borealin family.
messages: centromere

367110:NCU01360
gene id: 367110:NCU01360
uniprot id: Q1K6N5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane

367110:NCU04336
gene id: 367110:NCU04336
uniprot id: Q7RX40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU01930
gene id: 367110:NCU01930
uniprot id: Q7SDP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

367110:NCU07428
gene id: 367110:NCU07428
uniprot id: Q7SF24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

367110:NCU00427
gene id: 367110:NCU00427
uniprot id: Q7RXT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: P-body

367110:NCU00249
gene id: 367110:NCU00249
uniprot id: Q7RZW2
names: Similarity
messages: Belongs to the peptidase A1 family.

367110:NCU00146
gene id: 367110:NCU00146
uniprot id: Q7RXR2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
messages: Membrane

367110:NCU02960
gene id: 367110:NCU02960
uniprot id: Q7SH09
names: Similarity
messages: Belongs to the peroxisomal targeting signal receptor family.

367110:NCU03223
gene id: 367110:NCU03223
uniprot id: V5IQQ1
uniprot id: V5IRL2
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

367110:NCU04065
gene id: 367110:NCU04065
uniprot id: Q7RZF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

367110:NCU01175
gene id: 367110:NCU01175
uniprot id: Q92250
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FPP/GGPP synthase family.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
messages: Cytoplasm

367110:NCU08115
gene id: 367110:NCU08115
uniprot id: Q7SD11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.
messages: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh-2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. Msh-3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).
messages: Heterodimer consisting of msh-2-msh-3 (MutS beta). Forms a ternary complex with MutL alpha (mlh-1-pms-1) (By similarity).
messages: Nucleus

367110:NCU01157
gene id: 367110:NCU01157
uniprot id: Q8X0X0
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.

367110:NCU04640
gene id: 367110:NCU04640
uniprot id: V5ILX5
uniprot id: V5IMJ8
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

367110:NCU02936
gene id: 367110:NCU02936
uniprot id: Q7SHG8
names: Function
names: Similarity
messages: Belongs to the proline oxidase family.
messages: Converts proline to delta-1-pyrroline-5-carboxylate.

367110:NCU02704
gene id: 367110:NCU02704
uniprot id: Q7SH25
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

367110:NCU08152
gene id: 367110:NCU08152
uniprot id: Q7S496
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU00551
gene id: 367110:NCU00551
uniprot id: Q7SF97
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

367110:NCU07442
gene id: 367110:NCU07442
uniprot id: Q7SF12
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

367110:NCU02265
gene id: 367110:NCU02265
uniprot id: P19970
names: Function
names: Induction
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRQ family.
messages: By light; perhaps through white collar-1 (wc-1) and white collar-2 (wc-2). Also activated directly by wc-1 and wc-2.
messages: Circadian clock component involved in the generation of biological rhythms, in particular in rhythm stability, period length, and temperature compensation. Oscillates in abundance with a daily peak early in the morning. Behaves as a negative element in circadian transcriptional loop. May bind to wc-2 protein. The complex frq-wc-2 may turn off the expression of frq.
messages: Maintains rhythms at high temperature (30 degrees Celsius).
messages: Maintains rhythms at lower temperature (18 degrees Celsius).
messages: Nucleus
messages: Progressive phosphorylation during the late circadian day and early night. Phosphorylation is also involved in regulating frq degradation. Phosphorylation by CKII may have at least three functions; it decreases the stability of frq, reduces the protein complex formation between frq and the white collar proteins, and is important for the closing of the Neurospora circadian negative feedback loop.

367110:NCU09817
gene id: 367110:NCU09817
uniprot id: Q7SCQ0
names: Similarity
messages: Belongs to the class-I DAHP synthase family.

367110:NCU02802
gene id: 367110:NCU02802
uniprot id: Q01356
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrion inner membrane
messages: Required for arginine biosynthesis. May participate in the export of matrix-made ornithine into the cytosol (Potential).

367110:NCU05589
gene id: 367110:NCU05589
uniprot id: Q7S6X4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIP5 family.
messages: Cytoplasm
messages: May negatively regulate the snf-1 kinase.

367110:NCU01460
gene id: 367110:NCU01460
uniprot id: A3RNI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

367110:NCU03877
gene id: 367110:NCU03877
uniprot id: V5IKQ3
uniprot id: V5IM43
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

367110:NCU02066
gene id: 367110:NCU02066
uniprot id: Q7SEZ7
names: Similarity
messages: Belongs to the NOC2 family.

367110:NCU08930
gene id: 367110:NCU08930
uniprot id: P19968
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Complex I is composed of about 40 different subunits.
messages: Mitochondrion inner membrane
messages: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

367110:NCU04015
gene id: 367110:NCU04015
uniprot id: Q7RZJ2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS27 family.
messages: Both IUM domains are necessary for efficient binding to ubiquitin.
messages: Component of the ESCRT-0 complex composed of hse1 and vps27.
messages: Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.
messages: Endosome membrane
messages: The FYVE domain is involved in the binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) which is required for the association to endosomal membranes.

367110:NCU05650
gene id: 367110:NCU05650
uniprot id: Q7S610
names: Subcellular Location Annotation
messages: Cytoplasm

367110:NCU01245
gene id: 367110:NCU01245
uniprot id: Q1K6K5
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU00713
gene id: 367110:NCU00713
uniprot id: Q7SET3
names: Similarity
messages: Belongs to the isochorismatase family.

367110:NCU03267
gene id: 367110:NCU03267
uniprot id: Q7SEG1
names: Similarity
messages: Belongs to the NAD kinase family.

367110:NCU00743
gene id: 367110:NCU00743
uniprot id: Q7SED5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycogen debranching enzyme family.
messages: Cytoplasm
messages: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.

367110:NCU09432
gene id: 367110:NCU09432
uniprot id: V5IKR4
names: Similarity
messages: Belongs to the WD repeat L(2)GL family.

367110:NCU05804
gene id: 367110:NCU05804
uniprot id: Q7S5N9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL19 family.

367110:NCU00075
gene id: 367110:NCU00075
uniprot id: Q7RX75
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM14 family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to stimulate activity of mtHSP70 (hsp70-5) (By similarity).
messages: Heterodimer with un-4/pam16. Component of the PAM complex, at least composed of hsp70-5/ssc1, grpe/mge1, tim44, un-4/pam16, pam17 and tim14/pam18 (By similarity).
messages: Mitochondrion inner membrane
messages: The J domain is essential for co-chaperone activity and mediates the heterodimerization with the J-like domain of PAM16.

367110:NCU05222
gene id: 367110:NCU05222
uniprot id: Q7S8I5
names: Function
names: Similarity
messages: Belongs to the FYV10 family.
messages: Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.

367110:NCU10400
gene id: 367110:NCU10400
uniprot id: A7UX57
names: Similarity
messages: Belongs to the phospholipase D family.

367110:NCU05607
gene id: 367110:NCU05607
uniprot id: Q7S6V8
names: Similarity
messages: Belongs to the rtf2 family.

367110:NCU02372
gene id: 367110:NCU02372
uniprot id: Q7S4V4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates elongation factor 1-alpha at 'Lys-79'.

367110:NCU08510
gene id: 367110:NCU08510
uniprot id: Q7SC91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEN54 family.
messages: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. May be required to embody the molecular ruler of the complex (By similarity).
messages: tRNA splicing endonuclease is a heterotetramer composed of tsp-2/sen2, tsp-1/sen15, tsp-4/sen34 and tsp-5/sen54. Interacts directly with tsp-2/sen2 (By similarity).

367110:NCU04500
gene id: 367110:NCU04500
uniprot id: Q7RYA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.
messages: Secreted

367110:NCU04195
gene id: 367110:NCU04195
uniprot id: Q1K7D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

367110:NCU06348
gene id: 367110:NCU06348
uniprot id: Q7S9V8
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

367110:NCU16008
gene id: 367110:NCU16008
uniprot id: P05509
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4L family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Mitochondrion membrane

367110:NCU00104
gene id: 367110:NCU00104
uniprot id: P31540
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Has 2 AAA ATPase type nucleotide-binding domains (NBDs) per monomer. ATP binding to NBD1 triggers binding of polypeptides and stimulates ATP hydrolysis at NBD2. Nucleotide binding to NBD2 is crucial for oligomerization (By similarity).
messages: Homohexamer, forming a ring with a central pore.
messages: Nucleus
messages: Required, in concert with Hsp40 and Hsp70 and small Hsps, for the dissociation, resolubilization and refolding of aggregates of damaged proteins after heat or other environmental stresses. Extracts proteins from aggregates by unfolding and threading them in an ATP-dependent process through the axial channel of the protein hexamer, after which they can be refolded by components of the Hsp70/Hsp40 chaperone system (By similarity).
messages: The C-terminal extension is involved in oligomerization.

367110:NCU02152
gene id: 367110:NCU02152
uniprot id: V5IQ03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Nucleus

367110:NCU04596
gene id: 367110:NCU04596
uniprot id: A3RNH5
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.
messages: Heterodimer of a catalytic heavy chain and a regulatory light chain.

367110:NCU01399
gene id: 367110:NCU01399
uniprot id: Q7S762
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU01435
gene id: 367110:NCU01435
uniprot id: Q871M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: Nucleus
messages: Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the mus-8/ubc2 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity).

367110:NCU06276
gene id: 367110:NCU06276
uniprot id: Q7SB65
names: Function
names: Similarity
messages: Belongs to the IRS4 family.
messages: Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).

367110:NCU01215
gene id: 367110:NCU01215
uniprot id: Q1K831
names: Similarity
messages: Belongs to the thioesterase PaaI family.

367110:NCU09443
gene id: 367110:NCU09443
uniprot id: Q7S1X2
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06187
gene id: 367110:NCU06187
uniprot id: Q7SBI4
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

367110:NCU02464
gene id: 367110:NCU02464
uniprot id: Q7RW14
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

367110:NCU06198
gene id: 367110:NCU06198
uniprot id: Q7SBC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TPT transporter family. SLC35D subfamily.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homooligomer.
messages: Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.

367110:NCU10276
gene id: 367110:NCU10276
uniprot id: A7UWH5
names: Subcellular Location Annotation
messages: Membrane

367110:NCU07768
gene id: 367110:NCU07768
uniprot id: Q1K648
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU06416
gene id: 367110:NCU06416
uniprot id: Q7RYZ9
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

367110:NCU08810
gene id: 367110:NCU08810
uniprot id: Q7S8S5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM21 family.
messages: Component of the TIM23 complex, at least composed of tim23, tim17, tim50 and tim21.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix (By similarity).
messages: Mitochondrion inner membrane

367110:NCU03591
gene id: 367110:NCU03591
uniprot id: Q7S770
names: Subcellular Location Annotation
messages: Membrane

367110:NCU01613
gene id: 367110:NCU01613
uniprot id: V5IND0
uniprot id: V5INM3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily.

367110:NCU00831
gene id: 367110:NCU00831
uniprot id: V5IQ13
names: Similarity
messages: Belongs to the peptidase S28 family.

367110:NCU03880
gene id: 367110:NCU03880
uniprot id: Q7RXH0
names: Similarity
messages: Belongs to the cytidylyltransferase family.

367110:NCU10273
gene id: 367110:NCU10273
uniprot id: A7UWE4
names: Similarity
messages: Belongs to the SGT family.

367110:NCU01879
gene id: 367110:NCU01879
uniprot id: Q7SHC7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays a role in determining ER morphology.
messages: The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.

367110:NCU02015
gene id: 367110:NCU02015
uniprot id: Q7SFL7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Autopalmitoylated.
messages: Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.
messages: Endoplasmic reticulum membrane
messages: Palmitoyltransferase specific for Ras proteins.
messages: The DHHC domain is required for palmitoyltransferase activity.

367110:NCU00164
gene id: 367110:NCU00164
uniprot id: Q7RXP4
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU03968
gene id: 367110:NCU03968
uniprot id: Q7RZA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSE2 family.
messages: Nucleus

367110:NCU06071
gene id: 367110:NCU06071
uniprot id: Q7S4X9
names: Similarity
messages: Belongs to the ketopantoate reductase family.

367110:NCU02055
gene id: 367110:NCU02055
uniprot id: Q7SDE3
names: Similarity
messages: Belongs to the IUNH family.

367110:NCU08500
gene id: 367110:NCU08500
uniprot id: V5IPM8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS8 family.

367110:NCU01203
gene id: 367110:NCU01203
uniprot id: Q1K839
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP17 family.
messages: nucleolus

367110:NCU04854
gene id: 367110:NCU04854
uniprot id: Q7S390
names: Similarity
messages: Belongs to the glycosyl hydrolase 7 (cellulase C) family.

367110:NCU02572
gene id: 367110:NCU02572
uniprot id: Q7SHP3
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU01701
gene id: 367110:NCU01701
uniprot id: V5IPH8
uniprot id: V5IR37
names: Similarity
messages: Belongs to the FGGY kinase family.

367110:NCU00218
gene id: 367110:NCU00218
uniprot id: Q7RXK9
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

367110:NCU05294
gene id: 367110:NCU05294
uniprot id: Q7S904
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU03565
gene id: 367110:NCU03565
uniprot id: Q1K4V7
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

367110:NCU05894
gene id: 367110:NCU05894
uniprot id: Q7S514
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP6 family.
messages: nucleolus

367110:NCU03135
gene id: 367110:NCU03135
uniprot id: Q7SDV5
names: Similarity
messages: Belongs to the CMC family.

367110:NCU00366
gene id: 367110:NCU00366
uniprot id: Q7RYU2
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

367110:NCU01753
gene id: 367110:NCU01753
uniprot id: Q7RV00
names: Function
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.

367110:NCU06727
gene id: 367110:NCU06727
uniprot id: Q9Y8H7
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

367110:NCU04598
gene id: 367110:NCU04598
uniprot id: Q1K6C1
names: Similarity
messages: Belongs to the CCZ1 family.

367110:NCU09476
gene id: 367110:NCU09476
uniprot id: Q7SC06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS25 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Cytoplasm

367110:NCU04579
gene id: 367110:NCU04579
uniprot id: Q1K658
names: Similarity
messages: Belongs to the IlvD/Edd family.

367110:NCU07400
gene id: 367110:NCU07400
uniprot id: Q7S1L4
names: Subcellular Location Annotation
messages: cytoskeleton

367110:NCU08892
gene id: 367110:NCU08892
uniprot id: Q1K6A0
names: Similarity
messages: Belongs to the COG2 family.

367110:NCU01689
gene id: 367110:NCU01689
uniprot id: V5INA9
uniprot id: V5INK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

367110:NCU06519
gene id: 367110:NCU06519
uniprot id: Q7S874
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06218
gene id: 367110:NCU06218
uniprot id: Q7SBA5
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06319
gene id: 367110:NCU06319
uniprot id: Q7SAB2
names: Similarity
messages: Belongs to the glycosyl hydrolase 76 family.

367110:NCU03195
gene id: 367110:NCU03195
uniprot id: Q7SGX4
names: Function
names: Similarity
messages: Belongs to the Dus family. Dus3 subfamily.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs (By similarity). Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.

367110:NCU10292
gene id: 367110:NCU10292
uniprot id: Q6MW51
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethan group.

367110:NCU00410
gene id: 367110:NCU00410
uniprot id: Q1K5S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm

367110:NCU01479
gene id: 367110:NCU01479
uniprot id: Q7RVQ0
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

367110:NCU01455
gene id: 367110:NCU01455
uniprot id: A3RNH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP72 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
messages: Cytoplasm

367110:NCU03178
gene id: 367110:NCU03178
uniprot id: Q7SEV4
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU07443
gene id: 367110:NCU07443
uniprot id: Q7SF11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

367110:NCU09004
gene id: 367110:NCU09004
uniprot id: Q7S2W6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit.
messages: Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
messages: nucleolus

367110:NCU07054
gene id: 367110:NCU07054
uniprot id: Q7S5U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU02406
gene id: 367110:NCU02406
uniprot id: Q7S478
names: Similarity
messages: Belongs to the CWC22 family.

367110:NCU06573
gene id: 367110:NCU06573
uniprot id: Q7S844
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

367110:NCU09308
gene id: 367110:NCU09308
uniprot id: Q7SD85
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homodimer.
messages: Mitochondrion
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

367110:NCU06522
gene id: 367110:NCU06522
uniprot id: Q7S871
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU07927
gene id: 367110:NCU07927
uniprot id: Q7S9Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

367110:NCU07816
gene id: 367110:NCU07816
uniprot id: Q7SBE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

367110:NCU02559
gene id: 367110:NCU02559
uniprot id: Q7SHQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRG1 family.
messages: nucleolus

367110:NCU06743
gene id: 367110:NCU06743
uniprot id: F5HE85
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

367110:NCU00407
gene id: 367110:NCU00407
uniprot id: Q7RYQ3
names: Subcellular Location Annotation
messages: Chromosome

367110:NCU01181
gene id: 367110:NCU01181
uniprot id: Q1K855
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

367110:NCU05546
gene id: 367110:NCU05546
uniprot id: Q7S717
names: Subcellular Location Annotation
messages: Membrane

367110:NCU07169
gene id: 367110:NCU07169
uniprot id: Q1K5W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU09002
gene id: 367110:NCU09002
uniprot id: Q7S2W8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB3 subunit family.
messages: Mitochondrion inner membrane

367110:NCU00261
gene id: 367110:NCU00261
uniprot id: Q7RZV2
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

367110:NCU08477
gene id: 367110:NCU08477
uniprot id: P33723
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Preautophagosomal structure membrane
messages: Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP).
messages: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Ypt-1 regulates the trafficking of secretory vesicles from the endoplasmic reticulum (ER) to the Golgi. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum. Also involved in the recycling of membrane proteins.

367110:NCU07861
gene id: 367110:NCU07861
uniprot id: Q7SBU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU04468
gene id: 367110:NCU04468
uniprot id: Q7RYD9
names: Subcellular Location Annotation
messages: Membrane

367110:NCU05551
gene id: 367110:NCU05551
uniprot id: Q7S712
names: Subcellular Location Annotation
messages: Membrane

367110:NCU01615
gene id: 367110:NCU01615
uniprot id: Q7RU49
names: Similarity
messages: Belongs to the Tango6 family.

367110:NCU09609
gene id: 367110:NCU09609
uniprot id: Q7RV28
names: Similarity
messages: Belongs to the CENP-C/MIF2 family.

367110:NCU08445
gene id: 367110:NCU08445
uniprot id: Q872S3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OS-9 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with missfolded ER lumenal proteins.
messages: Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation (By similarity).

367110:NCU11409
gene id: 367110:NCU11409
uniprot id: A7UXD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity).
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.
messages: Nucleus

367110:NCU03191
gene id: 367110:NCU03191
uniprot id: Q7SGX8
names: Similarity
messages: Belongs to the Rab GDI family.

367110:NCU02126
gene id: 367110:NCU02126
uniprot id: Q7SE49
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

367110:NCU07580
gene id: 367110:NCU07580
uniprot id: Q7RVR4
names: Similarity
messages: Belongs to the protein kinase superfamily.

367110:NCU00355
gene id: 367110:NCU00355
uniprot id: Q9C169
names: Developmental Stage
names: Function
names: Induction
names: Similarity
messages: Activity is predominant during late exponential growth and at the start of the conidiation process.
messages: Belongs to the catalase family.
messages: Induced under stress conditions, such as H(2)O(2), paraquat, cadmium, heat shock, uric acid and nitrate treatment.
messages: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.

367110:NCU09018
gene id: 367110:NCU09018
uniprot id: Q7S0R5
names: Similarity
messages: Belongs to the peptidase M28 family.

367110:NCU07820
gene id: 367110:NCU07820
uniprot id: Q7SBE4
names: Subcellular Location Annotation
messages: Membrane

367110:NCU05517
gene id: 367110:NCU05517
uniprot id: Q7S6S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGM101 family.
messages: mitochondrion nucleoid

367110:NCU08299
gene id: 367110:NCU08299
uniprot id: Q7SA88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins. mL44 forms a heterodimer with mL57 and stabilizes rRNA expansion segments 1/2 at a membrane-facing protuberance close to the point of attachment of the ribosome to the translocon in the membrane.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU02241
gene id: 367110:NCU02241
uniprot id: Q7S438
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLD2 family.
messages: Cytoplasm
messages: Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity).
messages: Nucleus

367110:NCU06843
gene id: 367110:NCU06843
uniprot id: P59671
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Component of the large ribosomal subunit (LSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

367110:NCU07666
gene id: 367110:NCU07666
uniprot id: V5INC8
uniprot id: V5INW4
names: Similarity
messages: Belongs to the CCDC124 family.

367110:NCU09028
gene id: 367110:NCU09028
uniprot id: Q7S2U7
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

367110:NCU08566
gene id: 367110:NCU08566
uniprot id: O13335
uniprot id: U9W3P4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nudE family.
messages: Required for nuclear migration within hyphae during vegetative growth.
messages: Self-associates. Interacts with nudF (nmp-1 or nmp-2) (By similarity).
messages: cytoskeleton

367110:NCU08275
gene id: 367110:NCU08275
uniprot id: Q7S8J2
names: Similarity
messages: Belongs to the group II decarboxylase family.

367110:NCU02996
gene id: 367110:NCU02996
uniprot id: Q9P3S1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endopolyphosphatase PPN1 family.
messages: Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.
messages: Processing by proteases in the vacuole may be required for activation.
messages: Vacuole membrane

367110:NCU01985
gene id: 367110:NCU01985
uniprot id: Q7SE75
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically inhibited by 3'-phosphoadenosine 5'-phosphosulfate (PAPS).
messages: Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.
messages: Cytoplasm
messages: Homohexamer. Dimer of trimers.
messages: In the C-terminal section; belongs to the APS kinase family.
messages: In the N-terminal section; belongs to the sulfate adenylyltransferase family.
messages: The adenylyl-sulfate kinase (APS kinase) is non-functional. It is involved in allosteric regulation by PAPS. PAPS binding induces a large rotational rearrangement of domains lowering the substrate affinity of the enzyme.

367110:NCU02122
gene id: 367110:NCU02122
uniprot id: Q7SE53
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06028
gene id: 367110:NCU06028
uniprot id: P11638
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Expression is induced in the presence of quinic acid (PubMed:6458044, PubMed:17597928). The expression of qa-lf appears to be autoregulated (PubMed:2943985, PubMed:12477937).
messages: Nucleus
messages: Transcription activator; part of the qa gene cluster that mediates the catabolism of quinic acid (QA) and as such, allows the use of QA as a sole carbon source (PubMed:2525625, PubMed:123642, PubMed:6458044, PubMed:6198093). Activates the expression of qa cluster genes by binding to a 16 base-pair consensus sequence 5'-GGRTAARYRYTTAYCC-3' present in the promoters of the target genes (PubMed:2951591). Regulates its own expression (PubMed:2943985). May regulate the expression of many other genes inclusing genes with products in 8 mutually connected metabolic pathways: (1) starch and sucrose metabolism; (2) glycolysis/glucanogenesis; (3) TCA Cycle; (4) butanoate metabolism; (5) pyruvate metabolism; (6) aromatic amino acid and QA metabolism; (7) valine, leucine, and isoleucine degradation; and (8) transport of sugars and amino acids (PubMed:17597928, PubMed:21695121).

367110:NCU03257
gene id: 367110:NCU03257
uniprot id: Q7SEH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

367110:NCU00569
gene id: 367110:NCU00569
uniprot id: Q7SF81
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 31 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: It is uncertain whether Met-1 or Met-6 is the initiator.
messages: Nucleus

367110:NCU08018
gene id: 367110:NCU08018
uniprot id: V5IMG3
names: Similarity
messages: Belongs to the FAH family.

367110:NCU02400
gene id: 367110:NCU02400
uniprot id: Q7S4N5
names: Function
names: Similarity
messages: Belongs to the peptidase C14B family.
messages: Involved in cell death (apoptosis).

367110:NCU03321
gene id: 367110:NCU03321
uniprot id: Q7SEM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat BOP1/ERB1 family.
messages: Component of the NOP7 complex, composed of erb1, nop7 and ytm1. The complex is held together by erb1, which interacts with nop7 via its N-terminal domain and with ytm1 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome.
messages: Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

367110:NCU03145
gene id: 367110:NCU03145
uniprot id: Q7SDU7
names: Subcellular Location Annotation
messages: Membrane

367110:NCU17269
gene id: 367110:NCU17269
uniprot id: V5IKH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

367110:NCU04483
gene id: 367110:NCU04483
uniprot id: Q7RYC4
names: Similarity
messages: Belongs to the FBPase class 1 family.

367110:NCU04037
gene id: 367110:NCU04037
uniprot id: Q7RZH8
names: Similarity
messages: Belongs to the glycosyltransferase 15 family.

367110:NCU04386
gene id: 367110:NCU04386
uniprot id: Q7RZ86
names: Subcellular Location Annotation
messages: Membrane

367110:NCU00845
gene id: 367110:NCU00845
uniprot id: Q7SD94
names: Similarity
messages: Belongs to the UPF0696 family.

367110:NCU04429
gene id: 367110:NCU04429
uniprot id: Q7RZ45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Mitochondrion inner membrane

367110:NCU00005
gene id: 367110:NCU00005
uniprot id: Q7RYA0
names: Subcellular Location Annotation
messages: Membrane

367110:NCU09732
gene id: 367110:NCU09732
uniprot id: Q7SEJ3
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

367110:NCU00052
gene id: 367110:NCU00052
uniprot id: Q7RWS0
names: Similarity
messages: Belongs to the CoA-transferase III family.

367110:NCU09602
gene id: 367110:NCU09602
uniprot id: Q01233
names: Induction
names: Similarity
messages: Belongs to the heat shock protein 70 family.
messages: By heat shock.

367110:NCU01312
gene id: 367110:NCU01312
uniprot id: O13493
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU09659
gene id: 367110:NCU09659
uniprot id: Q7S264
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

367110:NCU02629
gene id: 367110:NCU02629
uniprot id: Q7SDI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PurH family.
messages: cytosol

367110:NCU02136
gene id: 367110:NCU02136
uniprot id: Q7SE40
names: Function
names: Similarity
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.

367110:NCU08682
gene id: 367110:NCU08682
uniprot id: Q7S8V3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NST1 family.
messages: Cytoplasm
messages: May act as a negative regulator of salt tolerance.

367110:NCU07482
gene id: 367110:NCU07482
uniprot id: Q7SG58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
messages: Mitochondrion
messages: Nucleus

367110:NCU04997
gene id: 367110:NCU04997
uniprot id: Q7RW51
names: Similarity
messages: Belongs to the glycosyl hydrolase 10 (cellulase F) family.

367110:NCU00220
gene id: 367110:NCU00220
uniprot id: Q7RXK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

367110:NCU00742
gene id: 367110:NCU00742
uniprot id: Q7SED6
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

367110:NCU00413
gene id: 367110:NCU00413
uniprot id: Q7RVQ9
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

367110:NCU10521
gene id: 367110:NCU10521
uniprot id: A7UWV5
names: Similarity
messages: Belongs to the GST superfamily.

367110:NCU05429
gene id: 367110:NCU05429
uniprot id: V5IQZ6
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

367110:NCU03179
gene id: 367110:NCU03179
uniprot id: Q7SEV3
names: Function
names: Similarity
messages: Belongs to the BLOC1S4 family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting.

367110:NCU07907
gene id: 367110:NCU07907
uniprot id: Q7SA10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HRI1 family.
messages: Cytoplasm
messages: Nucleus

367110:NCU07662
gene id: 367110:NCU07662
uniprot id: Q1K8F8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat peroxin-7 family.
messages: Peroxisome matrix
messages: cytosol

367110:NCU06722
gene id: 367110:NCU06722
uniprot id: Q1K6W9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

367110:NCU05252
gene id: 367110:NCU05252
uniprot id: Q7S891
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the deoxyhypusine hydroxylase family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.
messages: Cytoplasm
messages: Nucleus

367110:NCU02118
gene id: 367110:NCU02118
uniprot id: Q7SCY6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.
messages: The DHHC domain is required for palmitoyltransferase activity.

367110:NCU03804
gene id: 367110:NCU03804
uniprot id: Q05681
uniprot id: V5ILG3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.
messages: Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

367110:NCU02717
gene id: 367110:NCU02717
uniprot id: Q7SGD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the crooked-neck family.
messages: Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication (By similarity).
messages: Nucleus

367110:NCU11197
gene id: 367110:NCU11197
uniprot id: A7UVY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

367110:NCU06149
gene id: 367110:NCU06149
uniprot id: Q7S5D9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity).
messages: Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.
messages: P-body
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

367110:NCU08437
gene id: 367110:NCU08437
uniprot id: Q1K8N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBT5 family.
messages: Membrane

367110:NCU08002
gene id: 367110:NCU08002
uniprot id: Q7SAN8
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

367110:NCU07309
gene id: 367110:NCU07309
uniprot id: Q7SA53
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.

367110:NCU04571
gene id: 367110:NCU04571
uniprot id: Q1K665
names: Similarity
messages: Belongs to the RRP7 family.

367110:NCU01411
gene id: 367110:NCU01411
uniprot id: Q1K6U3
names: Subcellular Location Annotation
messages: Membrane

367110:NCU04089
gene id: 367110:NCU04089
uniprot id: Q7RWM0
names: Similarity
messages: Belongs to the cytochrome P450 family.

367110:NCU01059
gene id: 367110:NCU01059
uniprot id: Q1K8A8
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

367110:NCU09649
gene id: 367110:NCU09649
uniprot id: V5IM44
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

367110:NCU07926
gene id: 367110:NCU07926
uniprot id: Q7S9Z2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

367110:NCU08893
gene id: 367110:NCU08893
uniprot id: Q1K699
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU00930
gene id: 367110:NCU00930
uniprot id: Q9C0N3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer; composed of 3 copies of tim9 and 3 copies of tim10, named soluble 70 kDa complex. Associates directly with the TIM22 complex, whose core is composed of tim22 and tim54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of tim10 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

367110:NCU09815
gene id: 367110:NCU09815
uniprot id: Q7SCQ2
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU08028
gene id: 367110:NCU08028
uniprot id: Q7SAL3
names: Similarity
messages: Belongs to the OPI10 family.

367110:NCU09773
gene id: 367110:NCU09773
uniprot id: Q7S189
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

367110:NCU02801
gene id: 367110:NCU02801
uniprot id: Q7SEL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

367110:NCU01193
gene id: 367110:NCU01193
uniprot id: Q1K844
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

367110:NCU00023
gene id: 367110:NCU00023
uniprot id: Q7RY82
names: Subcellular Location Annotation
messages: Membrane

367110:NCU01438
gene id: 367110:NCU01438
uniprot id: F5HGC3
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

367110:NCU02978
gene id: 367110:NCU02978
uniprot id: V5IR80
uniprot id: V5IRG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLA1 family.
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

367110:NCU03690
gene id: 367110:NCU03690
uniprot id: Q1K804
names: Subcellular Location Annotation
messages: Cytoplasm

367110:NCU17261
gene id: 367110:NCU17261
uniprot id: V5ILP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

367110:NCU03388
gene id: 367110:NCU03388
uniprot id: F5HEN6
names: Similarity
messages: Belongs to the band 7/mec-2 family.

367110:NCU05253
gene id: 367110:NCU05253
uniprot id: Q7S890
names: Similarity
messages: Belongs to the asteroid family.

367110:NCU06108
gene id: 367110:NCU06108
uniprot id: Q7S5H9
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

367110:NCU04203
gene id: 367110:NCU04203
uniprot id: Q1K7D3
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

367110:NCU04870
gene id: 367110:NCU04870
uniprot id: Q7S375
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate esterase 1 (CE1) family.
messages: Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.
messages: Secreted

367110:NCU10732
gene id: 367110:NCU10732
uniprot id: P0C582
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane.
messages: Mitochondrion inner membrane

367110:NCU04121
gene id: 367110:NCU04121
uniprot id: Q1K7M9
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

367110:NCU08036
gene id: 367110:NCU08036
uniprot id: Q7SAK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the crooked-neck family.
messages: Involved in pre-mRNA splicing and cell cycle progression.
messages: Nucleus

367110:NCU03739
gene id: 367110:NCU03739
uniprot id: Q92249
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: By stress.
messages: Endoplasmic reticulum lumen

367110:NCU03137
gene id: 367110:NCU03137
uniprot id: Q7SDV3
names: Similarity
messages: Belongs to the lipin family.

367110:NCU00088
gene id: 367110:NCU00088
uniprot id: Q7RYN9
names: Cofactor
messages: Divalent metal ions. Mg(2+) is the most effective.

367110:NCU06194
gene id: 367110:NCU06194
uniprot id: Q7SBH9
names: Subcellular Location Annotation
messages: Membrane

367110:NCU05075
gene id: 367110:NCU05075
uniprot id: Q7RWK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

367110:NCU00050
gene id: 367110:NCU00050
uniprot id: Q7RWS2
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

367110:NCU06488
gene id: 367110:NCU06488
uniprot id: Q7RYI6
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU02479
gene id: 367110:NCU02479
uniprot id: Q7SG85
names: Similarity
messages: Belongs to the glutamine synthetase family.

367110:NCU03401
gene id: 367110:NCU03401
uniprot id: Q7RY10
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

367110:NCU03633
gene id: 367110:NCU03633
uniprot id: Q1K7Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Cytoplasm
messages: Mevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway. The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins.

367110:NCU08162
gene id: 367110:NCU08162
uniprot id: Q7S4I8
names: Similarity
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

367110:NCU02278
gene id: 367110:NCU02278
uniprot id: Q7S590
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06655
gene id: 367110:NCU06655
uniprot id: Q1K6M6
names: Similarity
messages: Belongs to the putative lipase ROG1 family.

367110:NCU01882
gene id: 367110:NCU01882
uniprot id: V5IP64
uniprot id: V5IRE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

367110:NCU03100
gene id: 367110:NCU03100
uniprot id: Q7SFZ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

367110:NCU08512
gene id: 367110:NCU08512
uniprot id: Q7SBY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

367110:NCU00621
gene id: 367110:NCU00621
uniprot id: Q7SI31
names: Similarity
messages: Belongs to the WD repeat RAPTOR family.

367110:NCU00762
gene id: 367110:NCU00762
uniprot id: Q7SDR1
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.
messages: Endoglucanase that plays an important role in biomass degradation. Binds onto plant cell walls to participate in the hydrolysis of cellulose.
messages: N-glycosylated.
messages: Secreted
messages: The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.

367110:NCU04445
gene id: 367110:NCU04445
uniprot id: Q7RZ29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

367110:NCU09103
gene id: 367110:NCU09103
uniprot id: Q7SFP7
names: Similarity
messages: Belongs to the cytochrome P450 family.

367110:NCU05995
gene id: 367110:NCU05995
uniprot id: P0CG70
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family.
messages: Cytoplasm
messages: For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.
messages: Nucleus
messages: Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
messages: Ubiquitin is encoded by 3 different genes. Crp-79 is synthesized as a polyprotein with one copy of ubiquitin fused to ribosomal protein eL40. Crp-6/ubi-3 is a polyprotein with one copy of ubiquitin fused to ribosomal protein eS31. Ubi is a polyprotein containing 4 exact head to tail repeats of ubiquitin.

367110:NCU05580
gene id: 367110:NCU05580
uniprot id: Q7S6Y3
names: Subcellular Location Annotation
messages: Membrane

367110:NCU02804
gene id: 367110:NCU02804
uniprot id: Q7SEK9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL59 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU03380
gene id: 367110:NCU03380
uniprot id: Q873H9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
messages: Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
messages: Component of pre-60S ribosomal complexes.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

367110:NCU09882
gene id: 367110:NCU09882
uniprot id: Q7S232
names: Function
names: Similarity
messages: Belongs to the peptidase C14B family.
messages: Involved in cell death (apoptosis).

367110:NCU03363
gene id: 367110:NCU03363
uniprot id: Q1K502
names: Similarity
messages: Belongs to the helicase family. SKI2 subfamily.

367110:NCU08943
gene id: 367110:NCU08943
uniprot id: Q1K6S0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU02828
gene id: 367110:NCU02828
uniprot id: Q7SCS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND2 (condensin subunit 2) family.
messages: Chromosome
messages: Cytoplasm

367110:NCU01290
gene id: 367110:NCU01290
uniprot id: Q1K6T3
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

367110:NCU01257
gene id: 367110:NCU01257
uniprot id: Q1K6R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP2 family.
messages: nucleolus

367110:NCU07920
gene id: 367110:NCU07920
uniprot id: Q7S9Z8
names: Similarity
messages: Belongs to the multicopper oxidase family.

367110:NCU08490
gene id: 367110:NCU08490
uniprot id: Q1K8Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.
messages: Membrane

367110:NCU02796
gene id: 367110:NCU02796
uniprot id: V5IQD7
uniprot id: V5IQP9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

367110:NCU08418
gene id: 367110:NCU08418
uniprot id: V5IQA7
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 Ca(2+) ion per subunit.
messages: extracellular space

367110:NCU00535
gene id: 367110:NCU00535
uniprot id: Q7SDK9
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.

367110:NCU10028
gene id: 367110:NCU10028
uniprot id: Q7S0F0
names: Subcellular Location Annotation
messages: Membrane

367110:NCU08357
gene id: 367110:NCU08357
uniprot id: Q7SGQ8
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU07253
gene id: 367110:NCU07253
uniprot id: Q7S962
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.

367110:NCU02274
gene id: 367110:NCU02274
uniprot id: P34898
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Cytoplasm
messages: Homotetramer.
messages: In eukaryotes there are two forms of the enzymes: a cytosolic one and a mitochondrial one.
messages: Interconversion of serine and glycine.

367110:NCU01063
gene id: 367110:NCU01063
uniprot id: Q1K8A5
names: Subcellular Location Annotation
messages: Secreted

367110:NCU05597
gene id: 367110:NCU05597
uniprot id: Q7S6W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU00852
gene id: 367110:NCU00852
uniprot id: Q7SD87
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

367110:NCU05392
gene id: 367110:NCU05392
uniprot id: Q9P3K9
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues (By similarity).

367110:NCU00269
gene id: 367110:NCU00269
uniprot id: Q7RZU4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.
messages: Chromosome
messages: Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.
messages: Nucleus
messages: The AWS and SET domains are necessary for transcription repression.

367110:NCU09745
gene id: 367110:NCU09745
uniprot id: Q7SEI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

367110:NCU04840
gene id: 367110:NCU04840
uniprot id: Q7S6J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG13 family. Fungi subfamily.
messages: Preautophagosomal structure

367110:NCU17267
gene id: 367110:NCU17267
uniprot id: V5IMR9
names: Similarity
messages: Belongs to the ustYa family.

367110:NCU11188
gene id: 367110:NCU11188
uniprot id: A7UVV8
names: Function
names: Similarity
names: Subunit
messages: Associates with DNA double-strand breaks.
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.
messages: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.

367110:NCU07381
gene id: 367110:NCU07381
uniprot id: Q7S2I1
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU01772
gene id: 367110:NCU01772
uniprot id: Q1K5Q5
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

367110:NCU06106
gene id: 367110:NCU06106
uniprot id: Q7S5I1
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06366
gene id: 367110:NCU06366
uniprot id: V5IQ54
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Vacuole membrane

367110:NCU01857
gene id: 367110:NCU01857
uniprot id: Q7SHE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. SKI2 subfamily.
messages: Cytoplasm

367110:NCU08008
gene id: 367110:NCU08008
uniprot id: Q7SAN3
names: Similarity
messages: Belongs to the CAP family.

367110:NCU00475
gene id: 367110:NCU00475
uniprot id: Q7RXX0
names: Similarity
messages: Belongs to the universal ribosomal protein uS13 family.

367110:NCU00090
gene id: 367110:NCU00090
uniprot id: Q7RVQ8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by C-terminal proteolytic cleavage by signaling protease (probably palB/RIM13) at neutral to alkaline ambient pH.
messages: Belongs to the pacC/RIM101 family.
messages: Binds to DNA. Interacts with palA/prr-1, which binds to the two YPX[LI] motifs and is required for proteolytic processing (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including pacc-1 itself) and represses transcription of acid-expressed genes (By similarity).

367110:NCU02414
gene id: 367110:NCU02414
uniprot id: Q7S4E5
names: Similarity
messages: Belongs to the eIF-2B gamma/epsilon subunits family.

367110:NCU07499
gene id: 367110:NCU07499
uniprot id: Q7SG43
names: Similarity
messages: Belongs to the PGA52 family.

367110:NCU01101
gene id: 367110:NCU01101
uniprot id: Q8X0G8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIM1 family.
messages: Mitochondrion outer membrane
messages: Required for the assembly of the TOM (translocase of outer membrane) receptor complex, which is responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins.

367110:NCU08166
gene id: 367110:NCU08166
uniprot id: Q7S4I4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Membrane
messages: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
messages: Mitochondrion inner membrane

367110:NCU03823
gene id: 367110:NCU03823
uniprot id: Q1K7F2
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

367110:NCU03593
gene id: 367110:NCU03593
uniprot id: Q7S7W0
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU05206
gene id: 367110:NCU05206
uniprot id: Q9HFW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the G-alpha family. G(q) subfamily.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Involved in conidiation.

367110:NCU02585
gene id: 367110:NCU02585
uniprot id: Q7SHN3
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.

367110:NCU16534
gene id: 367110:NCU16534
uniprot id: Q9P3K8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Probable transporter.
messages: Vacuole membrane

367110:NCU08561
gene id: 367110:NCU08561
uniprot id: Q7SAV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

367110:NCU03760
gene id: 367110:NCU03760
uniprot id: Q1K7B5
names: Similarity
messages: Belongs to the acetyltransferase family. GNAT subfamily.

367110:NCU02382
gene id: 367110:NCU02382
uniprot id: Q7S3W3
names: Similarity
messages: Belongs to the peptidase C12 family.

367110:NCU05164
gene id: 367110:NCU05164
uniprot id: Q7S8G9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU06495
gene id: 367110:NCU06495
uniprot id: Q7RYI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

367110:NCU01270
gene id: 367110:NCU01270
uniprot id: V5ILL5
uniprot id: V5IP51
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

367110:NCU08944
gene id: 367110:NCU08944
uniprot id: V5IM13
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

367110:NCU00617
gene id: 367110:NCU00617
uniprot id: Q7SI34
names: Similarity
messages: Belongs to the phosducin family.

367110:NCU02395
gene id: 367110:NCU02395
uniprot id: Q7S4P0
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.

367110:NCU05040
gene id: 367110:NCU05040
uniprot id: Q7RX48
names: Similarity
messages: Belongs to the Gfa family.

367110:NCU02935
gene id: 367110:NCU02935
uniprot id: Q7SHG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CGI121/TPRKB family.
messages: Component of the EKC/KEOPS complex composed of at least bud32, cgi121, gon7, kae1 and pcc1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Cgi121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. Cgi121 is not required for tRNA modification (By similarity).
messages: Nucleus
messages: telomere

367110:NCU02018
gene id: 367110:NCU02018
uniprot id: Q7SFL4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU10220
gene id: 367110:NCU10220
uniprot id: A7UWZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation.
messages: Cytoplasm
messages: Nucleus

367110:NCU03713
gene id: 367110:NCU03713
uniprot id: Q1K7Y7
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

367110:NCU07395
gene id: 367110:NCU07395
uniprot id: V5IQW4
names: Similarity
messages: Belongs to the DNA2/NAM7 helicase family.

367110:NCU03159
gene id: 367110:NCU03159
uniprot id: Q7SEX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

367110:NCU09512
gene id: 367110:NCU09512
uniprot id: Q7S1Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

367110:NCU06454
gene id: 367110:NCU06454
uniprot id: U9W2S4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.

367110:NCU09756
gene id: 367110:NCU09756
uniprot id: Q7S0W1
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

367110:NCU08964
gene id: 367110:NCU08964
uniprot id: Q7S7F0
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

367110:NCU06418
gene id: 367110:NCU06418
uniprot id: Q7RYZ7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity).
messages: Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

367110:NCU07281
gene id: 367110:NCU07281
uniprot id: Q7S986
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPI family.
messages: Homodimer.
messages: In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.
messages: cytosol

367110:NCU01831
gene id: 367110:NCU01831
uniprot id: Q1K578
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTF2H2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.
messages: Nucleus

367110:NCU01838
gene id: 367110:NCU01838
uniprot id: V5IPE4
names: Function
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.
messages: Nitrilase that hydrolyzes preferentially phenylacetonitrile, but also (R,S)-mandelonitrile, and 2-phenylpropionitrile.

367110:NCU01765
gene id: 367110:NCU01765
uniprot id: P24918
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 75 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Complex I is composed of about 40 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized.
messages: Mitochondrion inner membrane

367110:NCU06988
gene id: 367110:NCU06988
uniprot id: Q7SAG2
names: Similarity
messages: Belongs to the TUBGCP family.

367110:NCU07002
gene id: 367110:NCU07002
uniprot id: Q7SAE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC2 family.
messages: Nucleus

367110:NCU09548
gene id: 367110:NCU09548
uniprot id: Q7S2B3
names: Similarity
messages: Belongs to the serine esterase family.

367110:NCU08294
gene id: 367110:NCU08294
uniprot id: P28349
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Pathway-specific regulatory gene of nitrate assimilation; it activates the transcription of the genes for nitrate and nitrite reductases.
messages: The glutamine-rich domain might function in activating gene expression.

367110:NCU00776
gene id: 367110:NCU00776
uniprot id: P00440
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the tyrosinase family.
messages: Binds 2 copper ions per subunit.
messages: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.

367110:NCU05211
gene id: 367110:NCU05211
uniprot id: Q7S9C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INCENP family.
messages: Nucleus
messages: spindle

367110:NCU06646
gene id: 367110:NCU06646
uniprot id: Q8X0V0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB5 family.
messages: Component of the 7-subunit TFIIH core complex composed of XPB/rad25, XPD/dnr-10, tcf-30/SSL1, tcf-29/TFB1, tcf-11/TFB2, tcf-14/TFB4 and rtf-1/TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of div-66/cyclin H, prk-3/KIN28 and rtf-2/TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
messages: Nucleus

367110:NCU08180
gene id: 367110:NCU08180
uniprot id: Q7S4B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU05974
gene id: 367110:NCU05974
uniprot id: Q7S222
names: Similarity
messages: Belongs to the glycosyl hydrolase 16 family.

367110:NCU01324
gene id: 367110:NCU01324
uniprot id: V5IN04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPC1 family.
messages: Membrane

367110:NCU02614
gene id: 367110:NCU02614
uniprot id: Q7SG06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIase H subfamily.
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

367110:NCU06345
gene id: 367110:NCU06345
uniprot id: Q7S9W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosyl-DNA phosphodiesterase family.
messages: Nucleus

367110:NCU07035
gene id: 367110:NCU07035
uniprot id: Q7S9A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.
messages: Secreted

367110:NCU00116
gene id: 367110:NCU00116
uniprot id: U9W323
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU05254
gene id: 367110:NCU05254
uniprot id: Q7S889
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

367110:NCU02162
gene id: 367110:NCU02162
uniprot id: Q7SEQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Mitochondrion inner membrane
messages: Probably involved in the biogenesis of the COX complex.

367110:NCU07067
gene id: 367110:NCU07067
uniprot id: Q7S6F6
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

367110:NCU01402
gene id: 367110:NCU01402
uniprot id: Q7S733
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

367110:NCU02011
gene id: 367110:NCU02011
uniprot id: Q7SFM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the importin beta family. Importin beta-1 subfamily.
messages: Cytoplasm

367110:NCU07894
gene id: 367110:NCU07894
uniprot id: Q7S882
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

367110:NCU09843
gene id: 367110:NCU09843
uniprot id: Q7S0G9
names: Subcellular Location Annotation
messages: nucleolus

367110:NCU00618
gene id: 367110:NCU00618
uniprot id: Q7RVN2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Cytoplasm

367110:NCU05296
gene id: 367110:NCU05296
uniprot id: Q7S902
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: microtubule organizing center

367110:NCU11282
gene id: 367110:NCU11282
uniprot id: A7UWE5
names: Similarity
messages: Belongs to the GPAT/DAPAT family.

367110:NCU02888
gene id: 367110:NCU02888
uniprot id: Q7SHL6
names: Similarity
messages: Belongs to the GST superfamily.

367110:NCU09112
gene id: 367110:NCU09112
uniprot id: Q7S154
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 14 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

367110:NCU01580
gene id: 367110:NCU01580
uniprot id: Q1K4W6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB4 family.
messages: Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
messages: Nucleus

367110:NCU00021
gene id: 367110:NCU00021
uniprot id: Q7RY84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CLU family.
messages: Cytoplasm
messages: May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.

367110:NCU01449
gene id: 367110:NCU01449
uniprot id: V5ILK6
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.

367110:NCU00966
gene id: 367110:NCU00966
uniprot id: Q7SGF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC3 family.
messages: Membrane
messages: The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).

367110:NCU05775
gene id: 367110:NCU05775
uniprot id: Q7S5R8
names: Similarity
messages: Belongs to the amino acid/polyamine transporter 2 family.

367110:NCU03608
gene id: 367110:NCU03608
uniprot id: P38674
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Mitochondrion

367110:NCU09437
gene id: 367110:NCU09437
uniprot id: Q7S1X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAP family.
messages: nucleolus

367110:NCU09842
gene id: 367110:NCU09842
uniprot id: Q7RVR1
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

367110:NCU04337
gene id: 367110:NCU04337
uniprot id: Q7RX39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVF1 family.
messages: Ceramide-binding protein that may transfer ceramides from the endoplasmic reticulum membrane to the cis-Golgi network membrane, and is thereby required for the biosynthesis of complex sphingolipids.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Nucleus
messages: cis-Golgi network membrane

367110:NCU00199
gene id: 367110:NCU00199
uniprot id: Q7RXM6
names: Subcellular Location Annotation
messages: nuclear pore complex

367110:NCU04883
gene id: 367110:NCU04883
uniprot id: Q7S062
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.
messages: Secreted

367110:NCU01643
gene id: 367110:NCU01643
uniprot id: Q8WZX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Nucleus
messages: Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II (By similarity).

367110:NCU09444
gene id: 367110:NCU09444
uniprot id: Q7S1X1
names: Subcellular Location Annotation
messages: Membrane

367110:NCU02371
gene id: 367110:NCU02371
uniprot id: Q7S4V5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Golgi apparatus membrane
messages: Probable rhomboid-type serine protease that catalyzes intramembrane proteolysis.
messages: cis-Golgi network membrane

367110:NCU16016
gene id: 367110:NCU16016
uniprot id: P03945
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 2 heme A groups non-covalently per subunit.
messages: Binds a copper B center.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 11 subunits. The complex is composed of a catalytic core of 3 subunits Cox1, Cox2 and Cox3, encoded in the mitochondrial DNA, and 8 supernumerary subunits Cox4, Cox5a/Cox5, Cox6, Cox7, Cox8, Cox7a/Cox9, Cox6b/Cox12 and Cox6a/Cox13, which are encoded in the nuclear genome (PubMed:31316820). The complex exists as a monomer or a dimer and forms respiratory supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in various different assemblies (supercomplexes I(1)IV(1), I(1)III(3)IV(2), III(2)IV(1) and III(2)IV(2) as well as larger supercomplexes of compositions like I(1)III(2)IV(5-6)) (PubMed:17873079).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of Cox2 and heme A of Cox1 to the active site in Cox1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane
messages: The amino end of the mature protein may be Ser-3.

367110:NCU02814
gene id: 367110:NCU02814
uniprot id: Q7SEK0
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.

367110:NCU10468
gene id: 367110:NCU10468
uniprot id: A7UWD5
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
messages: Heterodimer of an alpha and a beta chain.
messages: Mitochondrion matrix
messages: The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion.
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

367110:NCU07935
gene id: 367110:NCU07935
uniprot id: Q7S9Y3
names: Similarity
messages: Belongs to the MIX23 family.

367110:NCU08277
gene id: 367110:NCU08277
uniprot id: Q7S8J0
names: Similarity
messages: Belongs to the eIF-2-alpha family.

367110:NCU06637
gene id: 367110:NCU06637
uniprot id: V5IMJ5
names: Subcellular Location Annotation
messages: Peroxisome membrane

367110:NCU05766
gene id: 367110:NCU05766
uniprot id: Q7S4Q7
names: Similarity
messages: Belongs to the ustYa family.

367110:NCU00498
gene id: 367110:NCU00498
uniprot id: Q7RW32
names: Similarity
messages: In the C-terminal section; belongs to the MoaC family.
messages: In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.

367110:NCU01332
gene id: 367110:NCU01332
uniprot id: P31413
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1) (By similarity). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c'' (By similarity).
messages: Vacuole membrane

367110:NCU03617
gene id: 367110:NCU03617
uniprot id: Q1K7R5
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.

367110:NCU02640
gene id: 367110:NCU02640
uniprot id: Q7SDA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CGR1 family.
messages: Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.
messages: nucleolus

367110:NCU07553
gene id: 367110:NCU07553
uniprot id: Q7RZZ8
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU04491
gene id: 367110:NCU04491
uniprot id: V5IP23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

367110:NCU01652
gene id: 367110:NCU01652
uniprot id: Q1K4Z1
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

367110:NCU00727
gene id: 367110:NCU00727
uniprot id: Q7SEF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

367110:NCU05460
gene id: 367110:NCU05460
uniprot id: Q7RUQ4
names: Similarity
messages: Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.

367110:NCU01369
gene id: 367110:NCU01369
uniprot id: Q9P6U9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity).
messages: Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.
messages: Cytoplasm
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

367110:NCU17177
gene id: 367110:NCU17177
uniprot id: Q7S3C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.
messages: Cytoplasm
messages: Monomer.

367110:NCU09281
gene id: 367110:NCU09281
uniprot id: Q7S1M6
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity.

367110:NCU04597
gene id: 367110:NCU04597
uniprot id: Q1K6C2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAF1 family.
messages: Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.
messages: Nucleus

367110:NCU11050
gene id: 367110:NCU11050
uniprot id: A7UWL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Nucleus

367110:NCU04421
gene id: 367110:NCU04421
uniprot id: V5INK4
uniprot id: V5IQ95
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

367110:NCU07100
gene id: 367110:NCU07100
uniprot id: Q7S675
names: Similarity
messages: Belongs to the peptidase M20A family.

367110:NCU07474
gene id: 367110:NCU07474
uniprot id: Q7SCP1
names: Similarity
messages: Belongs to the fgaFS/easG family.

367110:NCU04753
gene id: 367110:NCU04753
uniprot id: Q7S6A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I NDUFB11 subunit family.
messages: Membrane

367110:NCU01231
gene id: 367110:NCU01231
uniprot id: Q1K823
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

367110:NCU01004
gene id: 367110:NCU01004
uniprot id: Q1K8E2
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. Interacts with pstB2. This interaction may be a means to structurally tether the donor membrane (ER) harboring PstB2 to acceptor membranes (Golgi/endosomes) harboring PSD2 during PtdSer transport to the site of PtdEtn synthesis.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.

367110:NCU08687
gene id: 367110:NCU08687
uniprot id: Q7S869
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

367110:NCU09115
gene id: 367110:NCU09115
uniprot id: Q7S0G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Membrane

367110:NCU07534
gene id: 367110:NCU07534
uniprot id: Q1K6C4
names: Similarity
messages: Belongs to the RdRP family.

367110:NCU01470
gene id: 367110:NCU01470
uniprot id: Q7RXW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.
messages: Vacuole membrane

367110:NCU04079
gene id: 367110:NCU04079
uniprot id: Q7RWN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAP1 family.
messages: Nucleus
messages: telomere

367110:NCU06968
gene id: 367110:NCU06968
uniprot id: Q7SAI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

367110:NCU03826
gene id: 367110:NCU03826
uniprot id: Q7S7R7
names: Similarity
messages: Belongs to the GST superfamily.

367110:NCU04262
gene id: 367110:NCU04262
uniprot id: Q1K7I4
names: Similarity
messages: Belongs to the glycosyl hydrolase 76 family.

367110:NCU01648
gene id: 367110:NCU01648
uniprot id: Q1K4Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

367110:NCU09391
gene id: 367110:NCU09391
uniprot id: Q7S2A1
names: Similarity
messages: Belongs to the PAL/histidase family.

367110:NCU04625
gene id: 367110:NCU04625
uniprot id: Q1K628
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

367110:NCU00552
gene id: 367110:NCU00552
uniprot id: P21334
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carotenoid/retinoid oxidoreductase family.
messages: Membrane
messages: Phytoene desaturase involved in the carotenoid biosynthesis pathway (PubMed:2144609, PubMed:11017770, PubMed:18812228). Converts phytoene into 3,4-didehydrolycopene via the intermediates phytofluene, zeta-carotene, neurosporene and lycopene, by introducing up to five double bonds into phytoene (PubMed:11017770, PubMed:18812228). Is also able to desaturate 1-hydroxyneurosporene into 1-hydroxylycopene and 1-hydroxylycopene into 1-hydroxy-3,4-didehydrolycopene (PubMed:11017770). Gamma-carotene and 1,19-dihydroxylycopene are not accepted as substrates (PubMed:11017770). Neurosporaxanthin is synthesized from geranyl-geranyl pyrophosphate (GGPP) through several enzymatic activities. Phytoene synthase activity performed by the bifunctional enzyme al-2 first produces phytoene from geranyl-geranyl pyrophosphate (GGPP). The phytoene dehydrogenase al-1 then introduces 5 desaturations to lead to 3,4-didehydrolycopene via the intermediates phytofluene, zeta-carotene, neurosporene and lycopene. Al-2 cyclase activity then converts 3,4-didehydrolycopene into torulene. Al-2 can also convet lycopene into gamma-carotene which in turn is converted to beta-carotene by an additional al-2 cyclization reaction. Torulene is the substrate of the dioxidase cao-2 that breaks the molecule, removing five carbon atoms to yield beta-apo-4'-carotenal, whereas the aldehyde dehydrogenase ylo-1 mediates the last step by converting beta-apo-4'-carotenal into neurosporaxanthin (Probable).
messages: The expression is subject to photoinduction.

367110:NCU11414
gene id: 367110:NCU11414
uniprot id: A7UXD9
names: Subcellular Location Annotation
messages: Membrane

367110:NCU05689
gene id: 367110:NCU05689
uniprot id: P06809
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5B family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 11 subunits. The complex is composed of a catalytic core of 3 subunits Cox1, Cox2 and Cox3, encoded in the mitochondrial DNA, and 8 supernumerary subunits Cox4, Cox5a/Cox5, Cox6, Cox7, Cox8, Cox7a/Cox9, Cox6b/Cox12 and Cox6a/Cox13, which are encoded in the nuclear genome (PubMed:31316820). The complex exists as a monomer or a dimer and forms respiratory supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in various different assemblies (supercomplexes I(1)IV(1), I(1)III(3)IV(2), III(2)IV(1) and III(2)IV(2) as well as larger supercomplexes of compositions like I(1)III(2)IV(5-6)) (PubMed:17873079).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of Cox2 and heme A of Cox1 to the active site in Cox1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

367110:NCU07498
gene id: 367110:NCU07498
uniprot id: Q7SG44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
messages: Nucleus

367110:NCU00326
gene id: 367110:NCU00326
uniprot id: U9WGW9
names: Similarity
messages: Belongs to the SMP-30/CGR1 family.

367110:NCU05537
gene id: 367110:NCU05537
uniprot id: Q7S6Q3
names: Similarity
messages: Belongs to the FAH family.

367110:NCU04435
gene id: 367110:NCU04435
uniprot id: Q7RZ39
names: Subcellular Location Annotation
messages: Membrane

367110:NCU01967
gene id: 367110:NCU01967
uniprot id: Q7SE93
names: Similarity
messages: Belongs to the ELP6 family.

367110:NCU06091
gene id: 367110:NCU06091
uniprot id: Q7S481
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Membrane

367110:NCU17008
gene id: 367110:NCU17008
uniprot id: V5IN81
names: Similarity
messages: Belongs to the SMAP family.

367110:NCU06105
gene id: 367110:NCU06105
uniprot id: Q7S5I2
names: Subunit
messages: Component of the ESCRT-0 complex composed of HSE1 and VPS27.

367110:NCU08678
gene id: 367110:NCU08678
uniprot id: Q7S8V7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMA20 family.
messages: Cytoplasm
messages: Involved in translation.

367110:NCU01916
gene id: 367110:NCU01916
uniprot id: Q7SH90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

367110:NCU06244
gene id: 367110:NCU06244
uniprot id: Q7SBR3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer; composed of 3 copies of tim8 and 3 copies of tim13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of tim22 and tim54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The tim8-tim13 complex is non essential and only mediates the import of few proteins, while the predominant tim9-tim10 70 kDa complex is crucial and mediates the import of much more proteins.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of tim13 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

367110:NCU04182
gene id: 367110:NCU04182
uniprot id: V5IMS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B4 family.
messages: Nucleus

367110:NCU06448
gene id: 367110:NCU06448
uniprot id: Q7RYW9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

367110:NCU06084
gene id: 367110:NCU06084
uniprot id: Q7S488
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).
messages: Belongs to the VPS51 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex.
messages: trans-Golgi network

367110:NCU08551
gene id: 367110:NCU08551
uniprot id: Q7SBJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.
messages: Chromosome
messages: Histone methyltransferase that trimethylates 'Lys-20' of histone H4 to form H4K20me3.
messages: Nucleus

367110:NCU08147
gene id: 367110:NCU08147
uniprot id: Q7RVS6
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.

367110:NCU04733
gene id: 367110:NCU04733
uniprot id: Q7S6H2
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

367110:NCU06215
gene id: 367110:NCU06215
uniprot id: Q7SBA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.
messages: Membrane

367110:NCU02632
gene id: 367110:NCU02632
uniprot id: Q7SDH8
names: Subcellular Location Annotation
messages: Membrane

367110:NCU07415
gene id: 367110:NCU07415
uniprot id: Q7S1F8
names: Similarity
messages: Belongs to the peptidase S33 family.

367110:NCU00376
gene id: 367110:NCU00376
uniprot id: U9W3F0
uniprot id: U9WGX9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Component of the GSE complex.
messages: GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.

367110:NCU04568
gene id: 367110:NCU04568
uniprot id: Q7S243
names: Subcellular Location Annotation
messages: Membrane

367110:NCU09999
gene id: 367110:NCU09999
uniprot id: Q7S054
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU05959
gene id: 367110:NCU05959
uniprot id: Q7S1W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Membrane

367110:NCU02250
gene id: 367110:NCU02250
uniprot id: P00842
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

367110:NCU07519
gene id: 367110:NCU07519
uniprot id: U9W3N2
uniprot id: U9W8Y3
names: Similarity
messages: Belongs to the helicase family.

367110:NCU03297
gene id: 367110:NCU03297
uniprot id: Q7SDV9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Forms a one-to-one complex with cytochrome c.
messages: Mitochondrion matrix

367110:NCU00619
gene id: 367110:NCU00619
uniprot id: Q7SI33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIF1/spd1 family.
messages: Cytoplasm
messages: Nucleus

367110:NCU06687
gene id: 367110:NCU06687
uniprot id: O93869
names: Activity Regulation
names: Function
names: Similarity
messages: Allosteric activation by glucose-6-phosphate, and phosphorylation by a cAMP-dependent kinase.
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. Is believed to regulate the synthesis of glycogen.

367110:NCU05057
gene id: 367110:NCU05057
uniprot id: Q7RXC7
names: Similarity
messages: Belongs to the glycosyl hydrolase 7 (cellulase C) family.

367110:NCU03355
gene id: 367110:NCU03355
uniprot id: Q1K520
names: Similarity
messages: Belongs to the peptidase C2 family. PalB/RIM13 subfamily.

367110:NCU07484
gene id: 367110:NCU07484
uniprot id: Q7SG57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.
messages: Secreted

367110:NCU05577
gene id: 367110:NCU05577
uniprot id: Q7S6Y6
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

367110:NCU01427
gene id: 367110:NCU01427
uniprot id: P24322
names: Caution
names: Cofactor
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FPP/GGPP synthase family.
messages: Binds 2 Mg(2+) ions per subunit.
messages: By blue light.
messages: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate.
messages: Cytoplasm
messages: It is uncertain whether Met-1 or Met-6 is the initiator.
messages: Main product.

367110:NCU00710
gene id: 367110:NCU00710
uniprot id: Q7SET6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate esterase 1 (CE1) family.
messages: Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.
messages: Secreted

367110:NCU03235
gene id: 367110:NCU03235
uniprot id: Q7SGT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

367110:NCU05457
gene id: 367110:NCU05457
uniprot id: P06810
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 11 subunits. The complex is composed of a catalytic core of 3 subunits Cox1, Cox2 and Cox3, encoded in the mitochondrial DNA, and 8 supernumerary subunits Cox4, Cox5a/Cox5, Cox6, Cox7, Cox8, Cox7a/Cox9, Cox6b/Cox12 and Cox6a/Cox13, which are encoded in the nuclear genome (PubMed:31316820). The complex exists as a monomer or a dimer and forms respiratory supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in various different assemblies (supercomplexes I(1)IV(1), I(1)III(3)IV(2), III(2)IV(1) and III(2)IV(2) as well as larger supercomplexes of compositions like I(1)III(2)IV(5-6)) (PubMed:17873079).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of Cox2 and heme A of Cox1 to the active site in Cox1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

367110:NCU04809
gene id: 367110:NCU04809
uniprot id: Q7S6M6
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

367110:NCU09798
gene id: 367110:NCU09798
uniprot id: Q7S5S3
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

367110:NCU05833
gene id: 367110:NCU05833
uniprot id: Q7S5L0
names: Subcellular Location Annotation
messages: Membrane

367110:NCU02032
gene id: 367110:NCU02032
uniprot id: Q1K918
names: Similarity
messages: Belongs to the glycosyl hydrolase 76 family.

367110:NCU02034
gene id: 367110:NCU02034
uniprot id: V5INW3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

367110:NCU04388
gene id: 367110:NCU04388
uniprot id: Q7RZ85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NPC2 family.
messages: Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
messages: Monomer.

367110:NCU06268
gene id: 367110:NCU06268
uniprot id: Q7SB72
names: Function
names: Similarity
messages: Belongs to the VPS16 family.
messages: Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.

367110:NCU06207
gene id: 367110:NCU06207
uniprot id: Q7SBB6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family.
messages: Catalyzes the introduction of a C-5 double bond in the B ring of ergosterol. May contribute to the regulation of ergosterol biosynthesis.
messages: Endoplasmic reticulum membrane
messages: The histidine box domains may contain the active site and/or be involved in metal ion binding.

367110:NCU02481
gene id: 367110:NCU02481
uniprot id: Q7SG83
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
messages: Can also use Mn(2+) ion.

367110:NCU06760
gene id: 367110:NCU06760
uniprot id: Q7SCC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

367110:NCU06550
gene id: 367110:NCU06550
uniprot id: Q9C1K6
names: Function
names: Similarity
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by pdx-2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers.

367110:NCU02114
gene id: 367110:NCU02114
uniprot id: Q7SDM0
names: Similarity
messages: Belongs to the cyclin family.

367110:NCU03230
gene id: 367110:NCU03230
uniprot id: Q7SGU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Mitochondrion

367110:NCU05633
gene id: 367110:NCU05633
uniprot id: Q7S5S5
names: Similarity
messages: Belongs to the band 7/mec-2 family.

367110:NCU05620
gene id: 367110:NCU05620
uniprot id: V5IN29
names: Similarity
messages: Belongs to the BLM10 family.

367110:NCU01084
gene id: 367110:NCU01084
uniprot id: Q8X0F1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NBP35 and two labile, bridging clusters between subunits of the NBP35-CFD1 heterotetramer.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
messages: Cytoplasm
messages: Heterotetramer of 2 NBP35 and 2 CFD1 chains.

367110:NCU04071
gene id: 367110:NCU04071
uniprot id: P38677
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cycloisomerase 2 family.
messages: Catalyzes a syn cycloisomerization. Also possesses mle activity.
messages: Homotetramer.

367110:NCU08952
gene id: 367110:NCU08952
uniprot id: Q1K6L3
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

367110:NCU08693
gene id: 367110:NCU08693
uniprot id: Q7RVX2
names: Similarity
messages: Belongs to the heat shock protein 70 family.

367110:NCU06317
gene id: 367110:NCU06317
uniprot id: Q7SAB4
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

367110:NCU08020
gene id: 367110:NCU08020
uniprot id: Q7SAM1
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

367110:NCU11305
gene id: 367110:NCU11305
uniprot id: A7UWN5
names: Similarity
messages: Belongs to the putative lipase ROG1 family.

367110:NCU11367
gene id: 367110:NCU11367
uniprot id: A7UX33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIT family. Fungal FIT2B/SCS3 subfamily.
messages: Endoplasmic reticulum membrane
messages: Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.
messages: Membrane

367110:NCU08358
gene id: 367110:NCU08358
uniprot id: Q7SGQ7
names: Subcellular Location Annotation
messages: Membrane

367110:NCU01271
gene id: 367110:NCU01271
uniprot id: P27121
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.
messages: Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
messages: Cytoplasm
messages: Homodimer (By similarity). Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers (By similarity).
messages: Inhibited by antizyme (AZ) OAZ1 in response to polyamine levels. AZ inhibits the assembly of the functional homodimer by binding to ODC monomers and targeting them for ubiquitin-independent proteolytic destruction by the 26S proteasome.
messages: It is uncertain whether Met-1 or Met-3 is the initiator.

367110:NCU07670
gene id: 367110:NCU07670
uniprot id: Q1K8F7
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activated by exposed helices in a group I intron RNA.
messages: Acts as an RNA chaperone to resolve non-native structures formed during RNA folding to promote mitochondrial group I, but also group II, intron splicing. Functions predominantly by disrupting accessible RNA secondary structure and depends on spontaneous openings in tightly packed RNAs to gain access to RNA helices.
messages: Belongs to the DEAD box helicase family.
messages: Mitochondrion matrix
messages: The C-ter region (residues 578-626) is not directly involved in DNA unwinding activity but functions by tethering cyt-19 to structured RNAs, so that it can efficiently disrupt exposed, non-native structural elements, allowing them to refold.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

367110:NCU02438
gene id: 367110:NCU02438
uniprot id: Q7S3Y3
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

367110:NCU04202
gene id: 367110:NCU04202
uniprot id: Q9UUY8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NDK family.
messages: Homotrimer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

367110:NCU02922
gene id: 367110:NCU02922
uniprot id: Q7SHI2
names: Caution
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: A recent genetics report associated srdA and its cluster with the biosynthesis of furanocoumarin neurosporin A, a metabolite produced by N.crassa for chemoresistance against predation by arthropod fungivores (PubMed:28485098). However, based on the gene cluster organization and predicted gene functions, this cluster is unlikely to be involved in neurosporin A biosynthesis, but instead produces compounds similar to pyriculol (PubMed:30908040).
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Expression is up-regulated during sexual development (PubMed:19277664). Expression is also up-regulated during confrontation with the arthropod fungivore Drosophila melanogaster (PubMed:28485098).
messages: Membrane
messages: Short-chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of sordarial, a salicylic aldehyde structurally related to the phytotoxin pyriculol (PubMed:19277664, PubMed:28485098, PubMed:30908040). The most interesting aspect of this pathway is formation of an aromatic product from the highly reducing polyketide synthase srdA (PubMed:30908040). SrdA synthesizes a reduced polyketide chain from one molecule of acetyl-CoA and five molecules of malonyl-CoA (PubMed:30908040). The polyketide chain is then reductively released as an aldehyde (PubMed:30908040). The oxidoreductases srdC, srdD and srdE then oxidize one of the hydroxy groups to facilitate the intramolecular aldol condensation, followed by dehydration to yield a salicylic aldehyde (PubMed:30908040). This aldehyde can undergo facile reduction by endogenous reductases to yield the alcohol 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene (PubMed:30908040). The flavin-dependent srdI counteract against the propensity of the aldehydes to be reduced under physiological conditions and is responsible for reoxidizing 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene back to the salicylic aldehyde (PubMed:30908040). This salicylic aldehyde is then selectively epoxidized by the cupin-domain-containing oxidoreductase srdB to yield the epoxide, which can be hydrolyzed stereoselectively by the hydrolase srdG to give the final product sordarial (PubMed:30908040).

367110:NCU00380
gene id: 367110:NCU00380
uniprot id: Q7RYS9
names: Similarity
messages: Belongs to the MIF family.

367110:NCU02926
gene id: 367110:NCU02926
uniprot id: Q7SHH8
names: Caution
names: Function
names: Induction
names: Similarity
messages: A recent genetics report associated srdA and its cluster with the biosynthesis of furanocoumarin neurosporin A, a metabolite produced by N.crassa for chemoresistance against predation by arthropod fungivores (PubMed:28485098). However, based on the gene cluster organization and predicted gene functions, this cluster is unlikely to be involved in neurosporin A biosynthesis, but instead produces compounds similar to pyriculol (PubMed:30908040).
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
messages: Expression is up-regulated during sexual development (PubMed:19277664). Expression is also up-regulated during confrontation with the arthropod fungivore Drosophila melanogaster (PubMed:28485098).
messages: FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of sordarial, a salicylic aldehyde structurally related to the phytotoxin pyriculol (PubMed:19277664, PubMed:28485098, PubMed:30908040). The most interesting aspect of this pathway is formation of an aromatic product from the highly reducing polyketide synthase srdA (PubMed:30908040). SrdA synthesizes a reduced polyketide chain from one molecule of acetyl-CoA and five molecules of malonyl-CoA (PubMed:30908040). The polyketide chain is then reductively released as an aldehyde (PubMed:30908040). The oxidoreductases srdC, srdD and srdE then oxidize one of the hydroxy groups to facilitate the intramolecular aldol condensation, followed by dehydration to yield a salicylic aldehyde (PubMed:30908040). This aldehyde can undergo facile reduction by endogenous reductases to yield the alcohol 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene (PubMed:30908040). The flavin-dependent srdI counteract against the propensity of the aldehydes to be reduced under physiological conditions and is responsible for reoxidizing 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene back to the salicylic aldehyde (PubMed:30908040). This salicylic aldehyde is then selectively epoxidized by the cupin-domain-containing oxidoreductase srdB to yield the epoxide, which can be hydrolyzed stereoselectively by the hydrolase srdG to give the final product sordarial (PubMed:30908040).

367110:NCU03966
gene id: 367110:NCU03966
uniprot id: Q7RZA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.
messages: Mitochondrion outer membrane

367110:NCU02280
gene id: 367110:NCU02280
uniprot id: P25710
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Complex I is composed of about 40 different subunits.
messages: Mitochondrion inner membrane
messages: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

367110:NCU07066
gene id: 367110:NCU07066
uniprot id: Q7S6F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERCC1/RAD10/SWI10 family.
messages: Nucleus

367110:NCU07558
gene id: 367110:NCU07558
uniprot id: Q7S1Z5
names: Similarity
messages: Belongs to the RMD1/sif2 family.

367110:NCU10044
gene id: 367110:NCU10044
uniprot id: Q7S088
names: Similarity
messages: Belongs to the AP endonuclease 2 family.

367110:NCU00609
gene id: 367110:NCU00609
uniprot id: Q7SI42
names: Similarity
messages: Belongs to the glycosyltransferase 32 family.

367110:NCU08734
gene id: 367110:NCU08734
uniprot id: Q7SCG1
names: Similarity
messages: Belongs to the peptidase S8 family.

367110:NCU03818
gene id: 367110:NCU03818
uniprot id: Q1K7F7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

367110:NCU03949
gene id: 367110:NCU03949
uniprot id: Q01284
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the nitronate monooxygenase family. NMO class II subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of alkyl nitronates to produce the corresponding carbonyl compounds and nitrites. Anionic forms of nitroalkanes are much better substrates than are neutral forms.
messages: Homodimer.

367110:NCU03901
gene id: 367110:NCU03901
uniprot id: Q1K602
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-14 family.
messages: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
messages: Peroxisome membrane

367110:NCU06038
gene id: 367110:NCU06038
uniprot id: Q7S4E7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL36 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins. bL36m has a zinc binding site.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU15832
gene id: 367110:NCU15832
uniprot id: U9W8S9
names: Subcellular Location Annotation
messages: Nucleus
messages: kinetochore

367110:NCU09123
gene id: 367110:NCU09123
uniprot id: V5IQT6
names: Similarity
messages: Belongs to the protein kinase superfamily.

367110:NCU06243
gene id: 367110:NCU06243
uniprot id: Q7SBR4
names: Similarity
messages: Belongs to the NSRP1 family.

367110:NCU06417
gene id: 367110:NCU06417
uniprot id: Q7RYZ8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

367110:NCU02522
gene id: 367110:NCU02522
uniprot id: Q7SHU1
names: Subcellular Location Annotation
messages: Membrane

367110:NCU08368
gene id: 367110:NCU08368
uniprot id: Q7SGP7
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

367110:NCU06191
gene id: 367110:NCU06191
uniprot id: U9W4L8
uniprot id: U9WGH7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

367110:NCU05117
gene id: 367110:NCU05117
uniprot id: Q1K5M2
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU03714
gene id: 367110:NCU03714
uniprot id: Q1K7Y6
names: Similarity
messages: Belongs to the DeSI family.

367110:NCU08060
gene id: 367110:NCU08060
uniprot id: Q7SGM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome b5 family.
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Mitochondrion outer membrane

367110:NCU06481
gene id: 367110:NCU06481
uniprot id: Q7RYJ3
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.

367110:NCU07019
gene id: 367110:NCU07019
uniprot id: Q7S8C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M67A family. CSN6 subfamily.
messages: Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity). The CSN complex is involved in the regulation of the circadian clock through its control of the stability of the SCF(FWD1) complex.
messages: Component of the COP9 signalosome (CSN) complex.
messages: Cytoplasm
messages: Nucleus

367110:NCU05897
gene id: 367110:NCU05897
uniprot id: Q7S511
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03891
gene id: 367110:NCU03891
uniprot id: Q7RZD6
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.

367110:NCU01248
gene id: 367110:NCU01248
uniprot id: Q7RVT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the telombin family.
messages: Nucleus
messages: telomere

367110:NCU07942
gene id: 367110:NCU07942
uniprot id: Q7S9X6
names: Similarity
messages: Belongs to the RRP1 family.

367110:NCU08738
gene id: 367110:NCU08738
uniprot id: Q7SCF7
names: Similarity
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.

367110:NCU03539
gene id: 367110:NCU03539
uniprot id: Q9UW15
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
messages: Under complex allosteric control mediated by deoxynucleoside triphosphates and ATP binding to separate specificity and activation sites on the large subunit. The type of nucleotide bound at the specificity site determines substrate preference. It seems probable that ATP makes the enzyme reduce CDP and UDP, dGTP favors ADP reduction and dTTP favors GDP reduction. Stimulated by ATP and inhibited by dATP binding to the activity site (By similarity).

367110:NCU04119
gene id: 367110:NCU04119
uniprot id: Q1K7N0
names: Similarity
messages: Belongs to the syntaxin family.

367110:NCU07155
gene id: 367110:NCU07155
uniprot id: Q7RZ22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ODC antizyme family.
messages: Interacts with ODC and thereby sterically blocks ODC homodimerization.
messages: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.

367110:NCU00087
gene id: 367110:NCU00087
uniprot id: Q7RYP0
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
messages: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

367110:NCU01956
gene id: 367110:NCU01956
uniprot id: Q7SDY1
names: Similarity
messages: Belongs to the SLA2 family.

367110:NCU06717
gene id: 367110:NCU06717
uniprot id: Q870U4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
messages: Belongs to the arsA ATPase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homodimer.

367110:NCU03107
gene id: 367110:NCU03107
uniprot id: Q7SFY7
names: Subcellular Location Annotation
messages: Membrane

367110:NCU00478
gene id: 367110:NCU00478
uniprot id: U9W570
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

367110:NCU01464
gene id: 367110:NCU01464
uniprot id: Q1K5C5
names: Similarity
messages: Belongs to the peptidase M14 family.

367110:NCU08823
gene id: 367110:NCU08823
uniprot id: P22126
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell membrane
messages: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

367110:NCU06190
gene id: 367110:NCU06190
uniprot id: Q7SBI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

367110:NCU08598
gene id: 367110:NCU08598
uniprot id: Q7SDG4
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

367110:NCU09119
gene id: 367110:NCU09119
uniprot id: Q7S2M9
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.

367110:NCU04485
gene id: 367110:NCU04485
uniprot id: Q7RYC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF1 family.
messages: nucleolus

367110:NCU06259
gene id: 367110:NCU06259
uniprot id: Q7SB54
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Endomembrane system
messages: Endosome membrane
messages: May be required for cytoplasm to vacuole transport (Cvt) and pexophagy.
messages: The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization to the perivacuolar punctate structures.

367110:NCU17251
gene id: 367110:NCU17251
uniprot id: V5ILN5
names: Similarity
messages: Belongs to the TRIAP1/MDM35 family.

367110:NCU04815
gene id: 367110:NCU04815
uniprot id: Q7S6M0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

367110:NCU07554
gene id: 367110:NCU07554
uniprot id: Q7S024
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC3 subfamily.
messages: Nucleus

367110:NCU00972
gene id: 367110:NCU00972
uniprot id: Q7SGF0
names: Similarity
messages: Belongs to the glycosyl hydrolase 53 family.

367110:NCU01950
gene id: 367110:NCU01950
uniprot id: Q7SDY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SLU7 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

367110:NCU05422
gene id: 367110:NCU05422
uniprot id: Q7SC32
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS11 family.
messages: Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.
messages: Vacuole membrane

367110:NCU01445
gene id: 367110:NCU01445
uniprot id: Q1K4R4
names: Similarity
messages: Belongs to the WAPL family.

367110:NCU07911
gene id: 367110:NCU07911
uniprot id: Q7SA06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IML2 family.
messages: Cytoplasm
messages: Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as chaperone in inclusion clearing.
messages: Interacts with lipid droplet proteins.
messages: Nucleus

367110:NCU06034
gene id: 367110:NCU06034
uniprot id: Q7S4F1
names: Subcellular Location Annotation
messages: Membrane

367110:NCU04155
gene id: 367110:NCU04155
uniprot id: Q1K7K5
names: Subcellular Location Annotation
messages: Cytoplasm

367110:NCU00980
gene id: 367110:NCU00980
uniprot id: Q7SGE2
names: Similarity
messages: Belongs to the SPT2 family.

367110:NCU01674
gene id: 367110:NCU01674
uniprot id: Q9P6A5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

367110:NCU00030
gene id: 367110:NCU00030
uniprot id: Q7RY75
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

367110:NCU09478
gene id: 367110:NCU09478
uniprot id: Q7SC05
names: Similarity
messages: Belongs to the CENP-X/MHF2 family.

367110:NCU07654
gene id: 367110:NCU07654
uniprot id: Q7SAX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIP1 family.
messages: Nucleus
messages: Pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase.

367110:NCU03037
gene id: 367110:NCU03037
uniprot id: Q7SDH1
names: Similarity
messages: Belongs to the dpy-30 family.

367110:NCU03266
gene id: 367110:NCU03266
uniprot id: Q7SEG2
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU06266
gene id: 367110:NCU06266
uniprot id: Q7SB74
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
messages: Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
messages: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
messages: Nucleus
messages: Ubiquitination of histone H2B to form H2BK123ub1 is required for efficient DOT1 methyltransferase activity on histone H3.

367110:NCU09551
gene id: 367110:NCU09551
uniprot id: Q7S2B0
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03245
gene id: 367110:NCU03245
uniprot id: Q7SCM6
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

367110:NCU05899
gene id: 367110:NCU05899
uniprot id: Q7S406
names: Similarity
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.

367110:NCU09680
gene id: 367110:NCU09680
uniprot id: Q1K6Q5
names: Similarity
messages: Belongs to the glycosyl hydrolase family 6.

367110:NCU16001
gene id: 367110:NCU16001
uniprot id: Q35137
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 2 family.
messages: Could be the product of a pseudogene. Product of a duplication of 2 fragments of the ndh-2 gene in the mitochondrial DNA. These 2 fragments, which are not contiguous in the ndh-2 gene, are connected to each other by a palindromic sequence of 37 bp and together they constitute an open reading frame.
messages: Mitochondrion membrane

367110:NCU00578
gene id: 367110:NCU00578
uniprot id: Q7SF72
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

367110:NCU00977
gene id: 367110:NCU00977
uniprot id: Q7SGE5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU06543
gene id: 367110:NCU06543
uniprot id: Q7S9I3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

367110:NCU02428
gene id: 367110:NCU02428
uniprot id: V5IKE3
uniprot id: V5ILI2
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

367110:NCU02626
gene id: 367110:NCU02626
uniprot id: Q7SDI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

367110:NCU00349
gene id: 367110:NCU00349
uniprot id: Q7RZL6
names: Similarity
messages: Belongs to the pinin family.

367110:NCU09608
gene id: 367110:NCU09608
uniprot id: Q9P5X8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. Eukaryotic subfamily.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Participates in DNA replication.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

367110:NCU04450
gene id: 367110:NCU04450
uniprot id: Q7RWB6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EXO5 family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Mitochondrion
messages: Monomer.
messages: Single strand DNA specific 5' exonuclease involved in mitochondrial DNA replication and recombination. Releases dinucleotides as main products of catalysis. Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively.

367110:NCU09317
gene id: 367110:NCU09317
uniprot id: Q7SDF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NXF family.
messages: nucleoplasm

367110:NCU07399
gene id: 367110:NCU07399
uniprot id: Q7S1L5
names: Similarity
messages: Belongs to the protein kinase superfamily.

367110:NCU03575
gene id: 367110:NCU03575
uniprot id: Q1K4T0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

367110:NCU03529
gene id: 367110:NCU03529
uniprot id: Q1K5E0
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU05523
gene id: 367110:NCU05523
uniprot id: Q7S6R6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
messages: Nucleus

367110:NCU09069
gene id: 367110:NCU09069
uniprot id: V5INR4
uniprot id: V5INY1
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03894
gene id: 367110:NCU03894
uniprot id: Q7RZD3
uniprot id: V5IL03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cytoplasm
messages: MAP4K component of the MAPK pathway required for the mating pheromone response and the regulation of cell polarity and cell cycle. Phosphorylates histone H2B to form H2BS10ph (By similarity).
messages: Nucleus

367110:NCU09774
gene id: 367110:NCU09774
uniprot id: Q7S188
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the faeC family.
messages: Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans, and the feruloyl-galactose ester bond in pectin. Active against paranitrophenyl-acetate, methyl ferulate and wheat arabinoxylan.
messages: Secreted

367110:NCU05878
gene id: 367110:NCU05878
uniprot id: Q7S530
names: Subcellular Location Annotation
messages: Membrane

367110:NCU08785
gene id: 367110:NCU08785
uniprot id: Q7RWX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the serine esterase family.
messages: Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans as well as the feruloyl-galactose and feruloyl-arabinose ester bonds in pectin (By similarity). Active against methyl esters of ferulate (MFA), sinapate (MSA), caffeate (MCA) and p-coumarate (MpCA) (PubMed:14595525).
messages: Secreted

367110:NCU02965
gene id: 367110:NCU02965
uniprot id: Q7SH04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC1 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Nucleus
messages: ORC is composed of six subunits.

367110:NCU08291
gene id: 367110:NCU08291
uniprot id: Q7SA94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Mitochondrion inner membrane

367110:NCU16028
gene id: 367110:NCU16028
uniprot id: P00411
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a dinuclear copper A center per subunit.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 11 subunits. The complex is composed of a catalytic core of 3 subunits Cox1, Cox2 and Cox3, encoded in the mitochondrial DNA, and 8 supernumerary subunits Cox4, Cox5a/Cox5, Cox6, Cox7, Cox8, Cox7a/Cox9, Cox6b/Cox12 and Cox6a/Cox13, which are encoded in the nuclear genome (PubMed:31316820). The complex exists as a monomer or a dimer and forms respiratory supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in various different assemblies (supercomplexes I(1)IV(1), I(1)III(3)IV(2), III(2)IV(1) and III(2)IV(2) as well as larger supercomplexes of compositions like I(1)III(2)IV(5-6)) (PubMed:17873079).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of Cox2 and heme A of Cox1 to the active site in Cox1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

367110:NCU04387
gene id: 367110:NCU04387
uniprot id: Q9Y756
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase F subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).
messages: Vacuole membrane

367110:NCU07626
gene id: 367110:NCU07626
uniprot id: Q7SAZ9
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

367110:NCU01754
gene id: 367110:NCU01754
uniprot id: Q9P6C8
uniprot id: V5IR31
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

367110:NCU09192
gene id: 367110:NCU09192
uniprot id: Q1K6E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

367110:NCU03794
gene id: 367110:NCU03794
uniprot id: Q9C270
names: Similarity
messages: Belongs to the WD repeat PWP2 family.

367110:NCU00998
gene id: 367110:NCU00998
uniprot id: Q7S824
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 5 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

367110:NCU08120
gene id: 367110:NCU08120
uniprot id: Q7SD06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS29 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Mitochondrion

367110:NCU04766
gene id: 367110:NCU04766
uniprot id: Q7S687
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU06549
gene id: 367110:NCU06549
uniprot id: Q1K8F5
names: Similarity
messages: Belongs to the glutaminase PdxT/SNO family.

367110:NCU09995
gene id: 367110:NCU09995
uniprot id: Q7S045
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NHP6 family.
messages: Chromosome
messages: DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex (By similarity).
messages: Nucleus
messages: Weakly associates with the stable heterodimer of ctc-1/pob3 and ctc-2/spt16 to form the FACT complex.

367110:NCU06624
gene id: 367110:NCU06624
uniprot id: V5IM01
uniprot id: V5INT0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

367110:NCU01797
gene id: 367110:NCU01797
uniprot id: O42626
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. KIN82 subfamily.
messages: Controls entry of the cell into the asexual developmental program. Required to repress entry into the conidiation program.

367110:NCU02067
gene id: 367110:NCU02067
uniprot id: Q7SEZ6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MDM12 family.
messages: Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of mmm-1, mdm10, mdm12 and mdm34. A mmm-1 homodimer associates with one molecule of mdm12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of mmm-1 and mdm12 generate a continuous hydrophobic tunnel for phospholipid trafficking.
messages: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10. The mdm12-mmm-1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The mdm10-mdm12-mmm-1 subcomplex further acts in the TOM40-specific pathway after the action of the mdm12-mmm1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane
messages: The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.

367110:NCU08303
gene id: 367110:NCU08303
uniprot id: Q7SA85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.
messages: Belongs to the peptidase S16 family.
messages: Peroxisome matrix

367110:NCU03988
gene id: 367110:NCU03988
uniprot id: Q7RXJ4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

367110:NCU02615
gene id: 367110:NCU02615
uniprot id: Q7SG05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

367110:NCU00836
gene id: 367110:NCU00836
uniprot id: Q7SCJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 61 family.
messages: Secreted

367110:NCU07175
gene id: 367110:NCU07175
uniprot id: V5ILS7
names: Subcellular Location Annotation
messages: Membrane

367110:NCU09155
gene id: 367110:NCU09155
uniprot id: Q7S0Y9
names: Similarity
messages: Belongs to the peptidase A1 family.

367110:NCU04075
gene id: 367110:NCU04075
uniprot id: Q7RZE5
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU01788
gene id: 367110:NCU01788
uniprot id: Q7RWF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
messages: Membrane

367110:NCU00728
gene id: 367110:NCU00728
uniprot id: Q7SEF0
names: Subcellular Location Annotation
messages: Membrane

367110:NCU16757
gene id: 367110:NCU16757
uniprot id: V5ILY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
messages: nucleolus

367110:NCU02024
gene id: 367110:NCU02024
uniprot id: Q7SF40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG29 family.
messages: Preautophagosomal structure

367110:NCU07205
gene id: 367110:NCU07205
uniprot id: Q7RZ10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Cell membrane
messages: Membrane

367110:NCU01366
gene id: 367110:NCU01366
uniprot id: V5ILF9
uniprot id: V5IP91
names: Similarity
messages: Belongs to the peptidase C48 family.

367110:NCU03466
gene id: 367110:NCU03466
uniprot id: Q1K518
names: Similarity
messages: Belongs to the TCP11 family.

367110:NCU00010
gene id: 367110:NCU00010
uniprot id: Q7RY95
names: Subcellular Location Annotation
messages: Membrane

367110:NCU08118
gene id: 367110:NCU08118
uniprot id: Q7SD08
names: Subcellular Location Annotation
messages: cytosol

367110:NCU00198
gene id: 367110:NCU00198
uniprot id: Q8J1Z1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer; composed of 3 copies of tim9 and 3 copies of tim10, named soluble 70 kDa complex. Associates with the tim22 complex, whose core is composed of tim22 and tim54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of tim9 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).

367110:NCU00874
gene id: 367110:NCU00874
uniprot id: V5IR05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.

367110:NCU00964
gene id: 367110:NCU00964
uniprot id: Q7SGF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MET18/MMS19 family.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus

367110:NCU03996
gene id: 367110:NCU03996
uniprot id: Q7RXI7
names: Similarity
messages: Belongs to the glycosyl hydrolase family 6.

367110:NCU08643
gene id: 367110:NCU08643
uniprot id: Q7S852
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

367110:NCU09301
gene id: 367110:NCU09301
uniprot id: Q7S1I0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family.
messages: Cytoplasm
messages: Preautophagosomal structure membrane
messages: Sterol glycosyltransferase responsible for the glycosylation of ergosterol to form ergosterol-glucoside.
messages: The GRAM and PH domains are required for the localization of ATG26 to the preautophagosomal structure (PAS) and are involved in autophagy (By similarity).

367110:NCU00735
gene id: 367110:NCU00735
uniprot id: Q7SEE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLX9 family.
messages: nucleolus

367110:NCU01800
gene id: 367110:NCU01800
uniprot id: Q1K548
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins. uS3m, uS4m and uS5m form the narrow entry site of the mRNA channel.
messages: Mitochondrion

367110:NCU00803
gene id: 367110:NCU00803
uniprot id: V5IR12
uniprot id: V5IRP9
names: Subcellular Location Annotation
messages: Membrane

367110:NCU09550
gene id: 367110:NCU09550
uniprot id: Q7S2B1
names: Subcellular Location Annotation
messages: Membrane

367110:NCU02070
gene id: 367110:NCU02070
uniprot id: Q7SEZ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.
messages: Membrane
messages: Peroxisome membrane

367110:NCU03394
gene id: 367110:NCU03394
uniprot id: Q1K5G1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Mitochondrion

367110:NCU16011
gene id: 367110:NCU16011
uniprot id: Q35136
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Encoded from partially processed ndh-5 mRNA that terminates with the in-frame coding sequence of the second intron.
messages: In the C-terminal section; belongs to the LAGLIDADG endonuclease family.
messages: In the N-terminal section; belongs to the complex I subunit 5 family.
messages: Mitochondrial DNA endonuclease involved in intron homing.
messages: Mitochondrion membrane

367110:NCU06761
gene id: 367110:NCU06761
uniprot id: Q1K8S9
names: Similarity
messages: Belongs to the group II decarboxylase family.

367110:NCU06309
gene id: 367110:NCU06309
uniprot id: Q7SAC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP25 family.
messages: Mitochondrion inner membrane
messages: Probable mitochondrial mRNA stabilization factor.

367110:NCU08092
gene id: 367110:NCU08092
uniprot id: Q7SGJ2
names: Similarity
messages: Belongs to the NipSnap family.

367110:NCU04899
gene id: 367110:NCU04899
uniprot id: Q7S1D6
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.

367110:NCU00575
gene id: 367110:NCU00575
uniprot id: Q7SF75
names: Similarity
messages: Belongs to the hexokinase family.

367110:NCU04198
gene id: 367110:NCU04198
uniprot id: Q7S7Q4
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU04174
gene id: 367110:NCU04174
uniprot id: Q1K7F1
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

367110:NCU04778
gene id: 367110:NCU04778
uniprot id: Q7S631
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

367110:NCU09646
gene id: 367110:NCU09646
uniprot id: Q7S277
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

367110:NCU08324
gene id: 367110:NCU08324
uniprot id: Q7SA64
names: Similarity
messages: Belongs to the HGH1 family.

367110:NCU01141
gene id: 367110:NCU01141
uniprot id: Q1K760
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
messages: Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
messages: Mitochondrion

367110:NCU03369
gene id: 367110:NCU03369
uniprot id: Q7RX22
names: Similarity
messages: Belongs to the pirin family.

367110:NCU06111
gene id: 367110:NCU06111
uniprot id: Q7S5H7
names: Subcellular Location Annotation
messages: Cell membrane

367110:NCU06860
gene id: 367110:NCU06860
uniprot id: Q7S0F5
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03214
gene id: 367110:NCU03214
uniprot id: Q7SGV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU03922
gene id: 367110:NCU03922
uniprot id: Q1K5Z3
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

367110:NCU10045
gene id: 367110:NCU10045
uniprot id: V5INE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pectinesterase family.
messages: Involved in maceration and soft-rotting of plant tissue.
messages: Secreted

367110:NCU00927
gene id: 367110:NCU00927
uniprot id: Q7SFC0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.

367110:NCU08763
gene id: 367110:NCU08763
uniprot id: Q1K4V4
names: Function
names: Similarity
messages: Belongs to the flavokinase family.
messages: Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.

367110:NCU03979
gene id: 367110:NCU03979
uniprot id: Q7RXK2
names: Similarity
messages: Belongs to the radical SAM superfamily. Biotin synthase family.

367110:NCU08607
gene id: 367110:NCU08607
uniprot id: Q7SFL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

367110:NCU02918
gene id: 367110:NCU02918
uniprot id: Q7SHI6
names: Caution
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
messages: A recent genetics report associated srdA and its cluster with the biosynthesis of furanocoumarin neurosporin A, a metabolite produced by N.crassa for chemoresistance against predation by arthropod fungivores (PubMed:28485098). However, based on the gene cluster organization and predicted gene functions, this cluster is unlikely to be involved in neurosporin A biosynthesis, but instead produces compounds similar to pyriculol (PubMed:30908040).
messages: Abolishes the production of the insecticidal furocoumarin neurosporin A (PubMed:28485098). Does not affect the fruiting body development and leads to normal fertility (PubMed:19277664).
messages: Expression is up-regulated during sexual development (PubMed:19277664). Expression is also up-regulated during confrontation with the arthropod fungivore Drosophila melanogaster (PubMed:28485098).
messages: Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of sordarial, a salicylic aldehyde structurally related to the phytotoxin pyriculol (PubMed:19277664, PubMed:28485098, PubMed:30908040). The most interesting aspect of this pathway is formation of an aromatic product from the highly reducing polyketide synthase srdA (PubMed:30908040). SrdA synthesizes a reduced polyketide chain from one molecule of acetyl-CoA and five molecules of malonyl-CoA (PubMed:30908040). The polyketide chain is then reductively released as an aldehyde (PubMed:30908040). The oxidoreductases srdC, srdD and srdE then oxidize one of the hydroxy groups to facilitate the intramolecular aldol condensation, followed by dehydration to yield a salicylic aldehyde (PubMed:30908040). This aldehyde can undergo facile reduction by endogenous reductases to yield the alcohol 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene (PubMed:30908040). The flavin-dependent srdI counteract against the propensity of the aldehydes to be reduced under physiological conditions and is responsible for reoxidizing 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene back to the salicylic aldehyde (PubMed:30908040). This salicylic aldehyde is then selectively epoxidized by the cupin-domain-containing oxidoreductase srdB to yield the epoxide, which can be hydrolyzed stereoselectively by the hydrolase srdG to give the final product sordarial (PubMed:30908040).
messages: Multidomain protein; including a ketosynthase (KS) that catalyzes repeated decarboxylative condensation to elongate the polyketide backbone; a malonyl-CoA:ACP transacylase (MAT) that selects and transfers the extender unit malonyl-CoA; a dehydratase (DH) domain that reduces hydroxyl groups to enoyl groups; an enoyl reductase (ER) domain that reduces enoyl groups to alkyl group; a ketoreductase (KR) domain that catalyzes beta-ketoreduction steps; and an acyl-carrier protein (ACP) that serves as the tether of the growing and completed polyketide via its phosphopantetheinyl arm.

367110:NCU00928
gene id: 367110:NCU00928
uniprot id: Q7SFB9
names: Similarity
messages: Belongs to the PHAF1 family.

367110:NCU09748
gene id: 367110:NCU09748
uniprot id: Q7SEH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.

367110:NCU02082
gene id: 367110:NCU02082
uniprot id: Q7SEY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFT1 family.
messages: Nucleus
messages: RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and hrp1/CFIB. Involved in poly(A) site recognition. May be involved in coupling transcription termination and mRNA 3'-end formation (By similarity).

367110:NCU01756
gene id: 367110:NCU01756
uniprot id: P78712
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP3 subfamily.
messages: Component of the Arp2/3 complex composed.
messages: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity).
messages: cytoskeleton

367110:NCU04610
gene id: 367110:NCU04610
uniprot id: Q1K6B0
names: Similarity
messages: Belongs to the OSBP family.

367110:NCU01724
gene id: 367110:NCU01724
uniprot id: Q1K4T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fungal Na(+)/H(+) exchanger family.
messages: Membrane

367110:NCU00670
gene id: 367110:NCU00670
uniprot id: P42117
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This subunit binds ubiquinone.
messages: Belongs to the complex I NDUFA3 subunit family.
messages: Complex I is composed of about 40 different subunits.
messages: Mitochondrion inner membrane

367110:NCU08225
gene id: 367110:NCU08225
uniprot id: Q7S3L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family.
messages: Cell membrane
messages: Membrane

367110:NCU00568
gene id: 367110:NCU00568
uniprot id: Q7SF82
names: Similarity
messages: Belongs to the peptidase A22B family.

367110:NCU02855
gene id: 367110:NCU02855
uniprot id: Q7SDQ1
names: Similarity
messages: Belongs to the glycosyl hydrolase 11 (cellulase G) family.

367110:NCU08412
gene id: 367110:NCU08412
uniprot id: Q7SC42
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

367110:NCU00136
gene id: 367110:NCU00136
uniprot id: Q7RWV7
names: Function
names: Similarity
messages: Belongs to the MnmG family.
messages: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.

367110:NCU06679
gene id: 367110:NCU06679
uniprot id: Q7S7N3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
messages: Component of the HAT-B complex composed of at least hat-1 and hat-2. The HAT-B complex binds to histone H4 tail.
messages: Cytoplasm
messages: Nucleus
messages: Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing.

367110:NCU00278
gene id: 367110:NCU00278
uniprot id: Q7RZT6
names: Similarity
messages: Belongs to the complex I NDUFA12 subunit family.

367110:NCU01452
gene id: 367110:NCU01452
uniprot id: Q871N9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Cytoplasm

367110:NCU02962
gene id: 367110:NCU02962
uniprot id: Q7SH07
names: Function
names: Similarity
messages: Belongs to the MUB1/samB family.
messages: Involved in determination of the onset of polarized growth and morphogenesis. Plays a role in the regulation of branching in hyphae and spore formation.

367110:NCU03833
gene id: 367110:NCU03833
uniprot id: P87072
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the calcineurin regulatory subunit family.
messages: Composed of a catalytic subunit (A) and a regulatory subunit (B).
messages: Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
messages: This protein has four functional calcium-binding sites.

367110:NCU00387
gene id: 367110:NCU00387
uniprot id: Q7RYS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.

367110:NCU02634
gene id: 367110:NCU02634
uniprot id: V5IQH3
uniprot id: V5IQU7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

367110:NCU06141
gene id: 367110:NCU06141
uniprot id: Q7S5E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Converts protoheme IX and farnesyl diphosphate to heme O.
messages: Mitochondrion membrane

367110:NCU01633
gene id: 367110:NCU01633
uniprot id: Q1K4S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU02573
gene id: 367110:NCU02573
uniprot id: V5IRG6
names: Similarity
messages: Belongs to the MIP18 family.

367110:NCU01760
gene id: 367110:NCU01760
uniprot id: F5HHH7
names: Function
names: Subcellular Location Annotation
messages: RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.
messages: nucleolus

367110:NCU00582
gene id: 367110:NCU00582
uniprot id: Q7SI68
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.
messages: Binds 1 FAD per subunit.
messages: May have a photoreceptor function.
messages: Mitochondrion

367110:NCU05805
gene id: 367110:NCU05805
uniprot id: Q7S5N8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Homotetramer.
messages: In eukaryotes there are two forms of the enzymes: a cytosolic one and a mitochondrial one.
messages: Interconversion of serine and glycine.
messages: Mitochondrion

367110:NCU07015
gene id: 367110:NCU07015
uniprot id: V5IQK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit and an accessory subunit.

367110:NCU08287
gene id: 367110:NCU08287
uniprot id: Q7S8A6
names: Similarity
messages: In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.

367110:NCU10077
gene id: 367110:NCU10077
uniprot id: Q7S014
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU02413
gene id: 367110:NCU02413
uniprot id: Q7S471
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU02452
gene id: 367110:NCU02452
uniprot id: Q7S454
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RTC5 family.
messages: Cytoplasm
messages: May be involved in a process influencing telomere capping.

367110:NCU07199
gene id: 367110:NCU07199
uniprot id: Q1K5U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU03766
gene id: 367110:NCU03766
uniprot id: V5IL57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

367110:NCU08883
gene id: 367110:NCU08883
uniprot id: Q7S2H0
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU05969
gene id: 367110:NCU05969
uniprot id: Q7S1V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 61 family.
messages: Secreted

367110:NCU02218
gene id: 367110:NCU02218
uniprot id: Q7S4H5
names: Similarity
messages: Belongs to the MDM20/NAA25 family.

367110:NCU05076
gene id: 367110:NCU05076
uniprot id: Q7RWK8
names: Subcellular Location Annotation
messages: Mitochondrion

367110:NCU06384
gene id: 367110:NCU06384
uniprot id: Q7S9G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU08553
gene id: 367110:NCU08553
uniprot id: Q7SBJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

367110:NCU02063
gene id: 367110:NCU02063
uniprot id: Q7SDD5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.
messages: Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).
messages: Mitochondrion matrix

367110:NCU08397
gene id: 367110:NCU08397
uniprot id: Q7SC23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

367110:NCU06472
gene id: 367110:NCU06472
uniprot id: Q7RYU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAT1 family.
messages: Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.
messages: Component of the HAT-B complex composed of at least hat-1 and hat-2. The HAT-B complex binds to histone H4 tail.
messages: Cytoplasm
messages: Nucleus

367110:NCU02397
gene id: 367110:NCU02397
uniprot id: Q7S4N8
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.

367110:NCU03571
gene id: 367110:NCU03571
uniprot id: Q1K4T2
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.

367110:NCU00126
gene id: 367110:NCU00126
uniprot id: Q7RYK3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERF4 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with ERF2.

367110:NCU09654
gene id: 367110:NCU09654
uniprot id: Q7S269
names: Subcellular Location Annotation
messages: Membrane

367110:NCU05009
gene id: 367110:NCU05009
uniprot id: Q12644
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Complex I is composed of about 40 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May donate electrons to ubiquinone.
messages: Mitochondrion

367110:NCU09570
gene id: 367110:NCU09570
uniprot id: Q7S4N0
names: Similarity
messages: Belongs to the GST superfamily.

367110:NCU05095
gene id: 367110:NCU05095
uniprot id: Q1K5N8
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.

367110:NCU00898
gene id: 367110:NCU00898
uniprot id: Q7SFD4
names: Function
names: Similarity
messages: Belongs to the FYV10 family.
messages: Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.

367110:NCU01955
gene id: 367110:NCU01955
uniprot id: Q7SDY2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG3 family.
messages: Cytoplasm
messages: E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of apg-6/atg8. The atg12-apg-4/atg5 conjugate plays a role of an E3 and promotes the transfer of apg-6/atg8 from apg-3/atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of apg-6/atg8. The formation of the apg-6/atg8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). The apg-6/atg8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity).
messages: Monomer. Interacts with apg-6/atg8 through an intermediate thioester bond through the C-terminal Gly of apg-6/atg8. Also interacts with the 40 amino acid C-terminal region of the E1-like apg-5/atg7 enzyme. Interacts also with the atg12-apg-4/atg5 conjugate.
messages: The N-terminal region is involved in phosphatidylethanolamine-binding and is required for apg-6/atg8-PE conjugation.
messages: The flexible region (FR) is required for apg-5/atg7-binding.
messages: The handle region (HR) contains the apg-6/atg8 interaction motif (AIM) and mediates binding to apg-6/atg8. It is crucial for the cytoplasm-to-vacuole targeting pathway (By similarity).

367110:NCU06037
gene id: 367110:NCU06037
uniprot id: Q7S4E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA40 subfamily.
messages: Cytoplasm
messages: Nucleus

367110:NCU03795
gene id: 367110:NCU03795
uniprot id: Q1K7H5
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

367110:NCU16698
gene id: 367110:NCU16698
uniprot id: U9W5F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

367110:NCU02509
gene id: 367110:NCU02509
uniprot id: Q7RVN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Component of the large ribosomal subunit (LSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

367110:NCU02020
gene id: 367110:NCU02020
uniprot id: Q7SFL2
names: Subcellular Location Annotation
messages: Membrane

367110:NCU02048
gene id: 367110:NCU02048
uniprot id: Q7SF30
names: Similarity
messages: Belongs to the UPF0507 family.

367110:NCU08860
gene id: 367110:NCU08860
uniprot id: Q8X0Q1
names: Function
names: Similarity
messages: Belongs to the LCL2 family.
messages: Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway.

367110:NCU04837
gene id: 367110:NCU04837
uniprot id: Q7S6J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

367110:NCU04612
gene id: 367110:NCU04612
uniprot id: V5INR7
names: Similarity
messages: Belongs to the protein kinase superfamily.

367110:NCU06305
gene id: 367110:NCU06305
uniprot id: Q7SAC5
names: Subcellular Location Annotation
messages: Membrane

367110:NCU09518
gene id: 367110:NCU09518
uniprot id: Q7S1P7
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

367110:NCU09390
gene id: 367110:NCU09390
uniprot id: V5IKV7
uniprot id: V5IMC2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU08312
gene id: 367110:NCU08312
uniprot id: Q7SA76
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

367110:NCU02683
gene id: 367110:NCU02683
uniprot id: Q7SH46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC3 family.
messages: Nucleus

367110:NCU09131
gene id: 367110:NCU09131
uniprot id: Q7S2L7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM RBM34 family.
messages: Involved in pre-25S rRNA processing.
messages: nucleolus

367110:NCU04316
gene id: 367110:NCU04316
uniprot id: Q1K722
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S10 family.
messages: Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).
messages: trans-Golgi network membrane

367110:NCU03883
gene id: 367110:NCU03883
uniprot id: Q7RXG7
names: Subcellular Location Annotation
messages: Membrane
messages: Vacuole membrane

367110:NCU04834
gene id: 367110:NCU04834
uniprot id: Q7S6K1
names: Subunit
messages: Homodimer.

367110:NCU00226
gene id: 367110:NCU00226
uniprot id: Q7RZY5
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06998
gene id: 367110:NCU06998
uniprot id: Q7SAF2
names: Similarity
messages: Belongs to the HIT family.

367110:NCU04321
gene id: 367110:NCU04321
uniprot id: Q1K719
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU00554
gene id: 367110:NCU00554
uniprot id: Q7SF95
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Homodimer.

367110:NCU00526
gene id: 367110:NCU00526
uniprot id: Q7SDL8
names: Similarity
messages: Belongs to the multicopper oxidase family.

367110:NCU00900
gene id: 367110:NCU00900
uniprot id: Q7SCV4
names: Similarity
messages: Belongs to the PPP4R2 family.

367110:NCU04216
gene id: 367110:NCU04216
uniprot id: F5HFP2
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

367110:NCU10775
gene id: 367110:NCU10775
uniprot id: V5IKM9
names: Subcellular Location Annotation
messages: Membrane

367110:NCU02381
gene id: 367110:NCU02381
uniprot id: Q7S4U6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

367110:NCU10618
gene id: 367110:NCU10618
uniprot id: A7UWQ5
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

367110:NCU09064
gene id: 367110:NCU09064
uniprot id: Q7SCT1
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.

367110:NCU04721
gene id: 367110:NCU04721
uniprot id: Q7S6I3
names: Similarity
messages: Belongs to the neutral ceramidase family.

367110:NCU02097
gene id: 367110:NCU02097
uniprot id: Q7SDB3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU00169
gene id: 367110:NCU00169
uniprot id: Q7RXN9
names: Subcellular Location Annotation
messages: Membrane

367110:NCU00019
gene id: 367110:NCU00019
uniprot id: Q7RY86
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU09220
gene id: 367110:NCU09220
uniprot id: Q870Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MON1/SAND family.
messages: Prevacuolar compartment membrane
messages: Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.
messages: Vacuole membrane
messages: multivesicular body membrane

367110:NCU05274
gene id: 367110:NCU05274
uniprot id: P38672
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Lys-57 undergoes hypusination, a unique post-translational modification that consists in the addition of a butylamino group from spermidine to lysine side chain, leading to the formation of the unusual amino acid hypusine. eIF-5As are the only known proteins to undergo this modification, which is essential for their function.
messages: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.

367110:NCU09191
gene id: 367110:NCU09191
uniprot id: Q1K6E8
names: Similarity
messages: Belongs to the NEMF family.

367110:NCU04535
gene id: 367110:NCU04535
uniprot id: Q7RY29
names: Subcellular Location Annotation
messages: cytoskeleton

367110:NCU06520
gene id: 367110:NCU06520
uniprot id: Q7S873
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
messages: Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily.
messages: Present with 1460 molecules/cell in log phase SD medium.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

367110:NCU08131
gene id: 367110:NCU08131
uniprot id: Q7S4K0
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

367110:NCU03546
gene id: 367110:NCU03546
uniprot id: Q1K5C9
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

367110:NCU09475
gene id: 367110:NCU09475
uniprot id: Q7RVI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Cytoplasm

367110:NCU06080
gene id: 367110:NCU06080
uniprot id: Q7S492
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

367110:NCU08341
gene id: 367110:NCU08341
uniprot id: Q7SGS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane

367110:NCU06189
gene id: 367110:NCU06189
uniprot id: Q7RVY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.
messages: Homodimer.
messages: Mitochondrion matrix

367110:NCU05119
gene id: 367110:NCU05119
uniprot id: Q1K5M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PET117 family.
messages: Mitochondrion

367110:NCU07656
gene id: 367110:NCU07656
uniprot id: Q7SAX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

367110:NCU11234
gene id: 367110:NCU11234
uniprot id: A7UW46
names: Similarity
messages: Belongs to the SUA5 family.

367110:NCU04479
gene id: 367110:NCU04479
uniprot id: Q7RYC8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M28 family. M28E subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Extracellular aminopeptidase that allows assimilation of proteinaceous substrates.
messages: Monomer.
messages: Secreted

367110:NCU05089
gene id: 367110:NCU05089
uniprot id: Q1K5P3
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03155
gene id: 367110:NCU03155
uniprot id: Q7SEX6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

367110:NCU03127
gene id: 367110:NCU03127
uniprot id: V5IQN1
uniprot id: V5IRK6
names: Cofactor
names: PTM
names: Similarity
messages: Binds 2 nickel ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two nickel ions.
messages: In the C-terminal section; belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.

367110:NCU02421
gene id: 367110:NCU02421
uniprot id: Q7S4D8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity).
messages: Belongs to the COG6 family.
messages: Golgi apparatus membrane

367110:NCU06055
gene id: 367110:NCU06055
uniprot id: Q7S4Z5
names: Similarity
messages: Belongs to the peptidase S8 family.

367110:NCU01998
gene id: 367110:NCU01998
uniprot id: Q7SFN3
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

367110:NCU16020
gene id: 367110:NCU16020
uniprot id: P0CY44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Mitochondrion membrane

367110:NCU02605
gene id: 367110:NCU02605
uniprot id: Q7SG15
names: Similarity
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.

367110:NCU09425
gene id: 367110:NCU09425
uniprot id: Q7S0S2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 94 family. Cellobionic acid phosphorylase subfamily.
messages: Catalyzes the reversible phosphorolysis of cellobionic acid (4-O-beta-D-glucopyranosyl-D-gluconate), a probable step in cellulose degradation. May be part of a metabolic pathway where cellobionic acid is converted into alpha-D-glucose 1-phosphate and D-gluconic acid to enter glycolysis and the pentose phosphate pathway, respectively. Produces 4-O-beta-D-glucopyranosyl-D-glucuronate from alpha-D-glucose 1-phosphate and D-glucuronate with low activity in the synthetic direction.
messages: Homodimer.

367110:NCU04548
gene id: 367110:NCU04548
uniprot id: Q7RWE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: DNA polymerase II participates in chromosomal DNA replication.
messages: Nucleus

367110:NCU01134
gene id: 367110:NCU01134
uniprot id: Q7RV13
names: Similarity
messages: Belongs to the cytochrome P450 family.

367110:NCU11263
gene id: 367110:NCU11263
uniprot id: V5IKZ8
uniprot id: V5IN80
names: Subcellular Location Annotation
messages: Cytoplasm

367110:NCU03789
gene id: 367110:NCU03789
uniprot id: Q7S7S4
names: Subcellular Location Annotation
messages: Membrane

367110:NCU07740
gene id: 367110:NCU07740
uniprot id: Q7S0V2
names: Subcellular Location Annotation
messages: Membrane

367110:NCU09830
gene id: 367110:NCU09830
uniprot id: Q7S1R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
messages: Membrane

367110:NCU01664
gene id: 367110:NCU01664
uniprot id: F5HCS7
names: Similarity
messages: Belongs to the TRAPPC13 family.

367110:NCU06318
gene id: 367110:NCU06318
uniprot id: Q7SAB3
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU03711
gene id: 367110:NCU03711
uniprot id: Q9C2L8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by guanine nucleotide-exchange factors (GEFs), and inactivated by GTPase-activating proteins (GAPs).
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Ypt/Rab-type GTPases are key regulators of membrane trafficking and intracellular vesicular transport. They act as molecular switches that convert between GTP-bound and GDP-bound states, and regulate virtually all steps of membrane traffic from the formation of the transport vesicle at the donor membrane to its fusion at the target membrane. In the GDP-bound state, Ypt proteins are predominantly cytosolic, solubilized through the interaction with a GDP dissociation inhibitor (GDI). In the GTP-bound state, the proteins are membrane bound and interact with specific effector proteins that select cargo, promote vesicle movement, or verify the correct site of fusion.

367110:NCU01546
gene id: 367110:NCU01546
uniprot id: F5H9D4
names: Similarity
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Homodimer.

367110:NCU02806
gene id: 367110:NCU02806
uniprot id: Q7RVK6
names: Similarity
messages: Belongs to the 14-3-3 family.

367110:NCU03480
gene id: 367110:NCU03480
uniprot id: Q1K508
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF4 family.
messages: Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
messages: Nucleus

367110:NCU09542
gene id: 367110:NCU09542
uniprot id: Q7S2B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IMPACT family.
messages: Cytoplasm

367110:NCU08379
gene id: 367110:NCU08379
uniprot id: Q7SGN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Necessary for protein translocation in the endoplasmic reticulum.

367110:NCU07965
gene id: 367110:NCU07965
uniprot id: Q7S920
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.

367110:NCU01990
gene id: 367110:NCU01990
uniprot id: Q7SFP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

367110:NCU04652
gene id: 367110:NCU04652
uniprot id: Q1K6G3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 3 (AP-3) is a heterotetramer.
messages: Belongs to the adaptor complexes large subunit family.
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.

367110:NCU02619
gene id: 367110:NCU02619
uniprot id: Q7SG01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Dus family. Dus3 subfamily.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs (By similarity). Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity).
messages: Cytoplasm
messages: Nucleus

367110:NCU01387
gene id: 367110:NCU01387
uniprot id: Q1K6Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: microtubule organizing center

367110:NCU03563
gene id: 367110:NCU03563
uniprot id: Q1K4V8
names: Similarity
messages: Belongs to the actin family.

367110:NCU03625
gene id: 367110:NCU03625
uniprot id: Q1K7Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: cytosol

367110:NCU04364
gene id: 367110:NCU04364
uniprot id: V5IP66
names: Similarity
messages: Belongs to the DNA polymerase type-B-like family.

367110:NCU03875
gene id: 367110:NCU03875
uniprot id: Q7RXH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

367110:NCU00778
gene id: 367110:NCU00778
uniprot id: Q7SFV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVP26 family.
messages: Membrane

367110:NCU00893
gene id: 367110:NCU00893
uniprot id: Q7SFD9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A monovalent cation.
messages: Belongs to the folylpolyglutamate synthase family.
messages: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.
messages: Membrane
messages: Mitochondrion inner membrane

367110:NCU08660
gene id: 367110:NCU08660
uniprot id: Q7S8P3
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.

367110:NCU06212
gene id: 367110:NCU06212
uniprot id: Q7SBB1
names: Similarity
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.

367110:NCU10058
gene id: 367110:NCU10058
uniprot id: Q7SCJ9
names: Similarity
messages: Belongs to the phosphohexose mutase family.

367110:NCU00043
gene id: 367110:NCU00043
uniprot id: Q9UW86
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm

367110:NCU08297
gene id: 367110:NCU08297
uniprot id: V5IM58
uniprot id: V5IMG4
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

367110:NCU07986
gene id: 367110:NCU07986
uniprot id: Q7SAQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

367110:NCU04921
gene id: 367110:NCU04921
uniprot id: Q7S3U6
names: Subcellular Location Annotation
messages: Membrane

367110:NCU04040
gene id: 367110:NCU04040
uniprot id: Q7RZH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.
messages: Cytoplasm
messages: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.

367110:NCU00973
gene id: 367110:NCU00973
uniprot id: Q7SGE9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

367110:NCU07741
gene id: 367110:NCU07741
uniprot id: Q7S0V1
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

367110:NCU07013
gene id: 367110:NCU07013
uniprot id: Q7S8D3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPAP2 family.
messages: Nucleus
messages: Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.

367110:NCU04005
gene id: 367110:NCU04005
uniprot id: V5IKR9
names: Similarity
messages: Belongs to the protein kinase superfamily.

367110:NCU00358
gene id: 367110:NCU00358
uniprot id: Q7RZK8
names: Domain
names: Function
names: Similarity
messages: Belongs to the IPK1 type 1 family.
messages: Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.
messages: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
messages: The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

367110:NCU06077
gene id: 367110:NCU06077
uniprot id: Q7S3X1
names: Subcellular Location Annotation
messages: Membrane

367110:NCU09864
gene id: 367110:NCU09864
uniprot id: Q7S5Z0
names: Function
names: Similarity
messages: Belongs to the BCKDHA family.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

367110:NCU08507
gene id: 367110:NCU08507
uniprot id: Q7SC94
names: Similarity
messages: Belongs to the ZPR1 family.

367110:NCU03498
gene id: 367110:NCU03498
uniprot id: Q1K4N8
names: Similarity
messages: Belongs to the multicopper oxidase family.

367110:NCU07451
gene id: 367110:NCU07451
uniprot id: Q7SF04
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

367110:NCU02565
gene id: 367110:NCU02565
uniprot id: Q7SHQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Belongs to the NDUFAF7 family.
messages: Mitochondrion

367110:NCU08352
gene id: 367110:NCU08352
uniprot id: P51978
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: The active site is a redox-active disulfide bond.

367110:NCU06878
gene id: 367110:NCU06878
uniprot id: Q7S3H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex DAM1 family.
messages: Nucleus
messages: kinetochore
messages: spindle

367110:NCU05945
gene id: 367110:NCU05945
uniprot id: Q7S2D3
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU06040
gene id: 367110:NCU06040
uniprot id: Q7S509
names: Subcellular Location Annotation
messages: Membrane

367110:NCU05267
gene id: 367110:NCU05267
uniprot id: Q7S858
names: Subcellular Location Annotation
messages: Cytoplasm

367110:NCU04358
gene id: 367110:NCU04358
uniprot id: Q7RW62
names: Similarity
messages: In the 2nd section; belongs to the type-I 3-dehydroquinase family.
messages: In the N-terminal section; belongs to the shikimate kinase family.

367110:NCU08874
gene id: 367110:NCU08874
uniprot id: Q7S793
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Part of the multisubunit TRAPP (transport protein particle) complex.
messages: Plays a key role in the late stages of endoplasmic reticulum to Golgi traffic.
messages: cis-Golgi network

367110:NCU00664
gene id: 367110:NCU00664
uniprot id: Q7SHY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the ISY1 family.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing.
messages: Nucleus

367110:NCU08991
gene id: 367110:NCU08991
uniprot id: Q8NK13
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SKP1 family.
messages: Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes (By similarity). Interacts with scon-2.
messages: Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor (By similarity).

367110:NCU01667
gene id: 367110:NCU01667
uniprot id: Q1K5I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.
messages: Mitochondrion matrix

367110:NCU03962
gene id: 367110:NCU03962
uniprot id: Q7RZA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the SRB8-11 complex, which itself associates with the Mediator complex.
messages: Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.
messages: Nucleus

367110:NCU09327
gene id: 367110:NCU09327
uniprot id: P47950
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNR ribonuclease family.
messages: Homodimer.
messages: Mitochondrion
messages: Required for RNA 5'- and 3'-end processing and splicing. May act on the RNA processing enzymes directly, or it may act on other regulatory molecules, which influence the activity or synthesis of these enzymes.

367110:NCU02731
gene id: 367110:NCU02731
uniprot id: Q7SGB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TLS1 family.
messages: Nucleus

367110:NCU11314
gene id: 367110:NCU11314
uniprot id: U9W2V1
uniprot id: U9W842
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U48 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU03305
gene id: 367110:NCU03305
uniprot id: Q1K909
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

367110:NCU08227
gene id: 367110:NCU08227
uniprot id: U9W3N6
uniprot id: U9W3S2
names: Similarity
messages: Belongs to the glycosyl hydrolase 12 (cellulase H) family.

367110:NCU02307
gene id: 367110:NCU02307
uniprot id: Q7S563
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU02387
gene id: 367110:NCU02387
uniprot id: Q7S4P7
names: Function
names: Similarity
messages: Belongs to the exportin family.
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.

367110:NCU07366
gene id: 367110:NCU07366
uniprot id: Q7S0B7
names: Function
messages: Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).

367110:NCU06403
gene id: 367110:NCU06403
uniprot id: Q7S9E4
names: Subcellular Location Annotation
messages: Membrane

367110:NCU16807
gene id: 367110:NCU16807
uniprot id: V5IML9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

367110:NCU03796
gene id: 367110:NCU03796
uniprot id: Q1K7H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

367110:NCU06447
gene id: 367110:NCU06447
uniprot id: Q7RYX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
messages: Membrane

367110:NCU02564
gene id: 367110:NCU02564
uniprot id: Q7SHQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.
messages: Mitochondrion outer membrane
messages: Putative cysteine synthase that catalyzes the conversion of O-acetyl-L-serine (OAS) into cysteine, the last step in the cysteine biosynthesis pathway. However, in contrast to cysteine synthase cys-17, this CS-like protein may not function in cysteine biosynthesis.

367110:NCU08909
gene id: 367110:NCU08909
uniprot id: Q1K677
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.

367110:NCU02587
gene id: 367110:NCU02587
uniprot id: Q7SHN1
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU03704
gene id: 367110:NCU03704
uniprot id: Q1K7Z3
names: Similarity
messages: Belongs to the peptidase C12 family.

367110:NCU07521
gene id: 367110:NCU07521
uniprot id: Q7S199
names: Similarity
messages: Belongs to the WD repeat MET30/SCONB/SCON-2 family.

367110:NCU09358
gene id: 367110:NCU09358
uniprot id: Q7S2N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU01900
gene id: 367110:NCU01900
uniprot id: Q7SHA6
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

367110:NCU09230
gene id: 367110:NCU09230
uniprot id: Q1K900
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

367110:NCU16624
gene id: 367110:NCU16624
uniprot id: U9W2Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTU2/NCS2 family.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.

367110:NCU02190
gene id: 367110:NCU02190
uniprot id: Q7S4D0
names: Similarity
messages: Belongs to the OSBP family.

367110:NCU09299
gene id: 367110:NCU09299
uniprot id: Q7S1I2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I NDUFA13 subunit family.
messages: Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.
messages: Mitochondrion inner membrane

367110:NCU02216
gene id: 367110:NCU02216
uniprot id: Q7S3X3
names: Similarity
messages: Belongs to the glycosyl hydrolase 76 family.

367110:NCU09012
gene id: 367110:NCU09012
uniprot id: Q7S0S1
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03204
gene id: 367110:NCU03204
uniprot id: Q7SGW5
names: Function
names: Similarity
messages: Belongs to the NARF family.
messages: Component of the cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins (By similarity).

367110:NCU08344
gene id: 367110:NCU08344
uniprot id: Q7RW15
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

367110:NCU06836
gene id: 367110:NCU06836
uniprot id: P16929
names: Induction
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: By acetate.

367110:NCU05169
gene id: 367110:NCU05169
uniprot id: Q7S8G4
names: Similarity
messages: Belongs to the catalase family.

367110:NCU06779
gene id: 367110:NCU06779
uniprot id: Q8X092
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum (By similarity).

367110:NCU10042
gene id: 367110:NCU10042
uniprot id: Q7RV85
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+) is required for catalysis and for stabilizing the dimer.

367110:NCU05544
gene id: 367110:NCU05544
uniprot id: V5IN44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM3 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.

367110:NCU03471
gene id: 367110:NCU03471
uniprot id: V5IPQ1
names: Similarity
messages: Belongs to the TPT transporter family. SLC35D subfamily.

367110:NCU05943
gene id: 367110:NCU05943
uniprot id: Q7S2D5
names: Function
names: Similarity
messages: Belongs to the BYE1 family.
messages: Negative regulator of transcription elongation.

367110:NCU02147
gene id: 367110:NCU02147
uniprot id: Q7SER9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKZF1/VMS1 family.
messages: Cytoplasm

367110:NCU08663
gene id: 367110:NCU08663
uniprot id: Q7S8P0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
messages: Belongs to the NMD3 family.
messages: Cytoplasm
messages: Nucleus

367110:NCU04534
gene id: 367110:NCU04534
uniprot id: Q7RY30
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
messages: Self-associates. Interacts with ro-11/nde1 and dynein.
messages: cytoskeleton
messages: spindle pole

367110:NCU06518
gene id: 367110:NCU06518
uniprot id: Q7S875
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Mitochondrion outer membrane

367110:NCU03093
gene id: 367110:NCU03093
uniprot id: Q03015
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Belongs to the complex I NDUFS6 subunit family.
messages: Complex I is composed of about 40 different subunits.
messages: Mitochondrion inner membrane

367110:NCU01932
gene id: 367110:NCU01932
uniprot id: Q7SDP1
names: Function
names: Subcellular Location Annotation
messages: Chromosome
messages: Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.

367110:NCU04013
gene id: 367110:NCU04013
uniprot id: Q1K615
names: Function
names: Induction
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: Beta-apo-4'-carotenal oxygenase involved in the last step of synthesis of neurosporaxanthin, a carboxylic apocarotenoid acting as an essential protective pigment and leading to orange pigmentation (PubMed:18627463, PubMed:18812228, PubMed:19007949). Converts the aldehyde beta-apo-4'-carotenal into neurosporaxanthin (PubMed:18627463, PubMed:18812228, PubMed:19007949). Neurosporaxanthin is synthesized from geranyl-geranyl pyrophosphate (GGPP) through several enzymatic activities. Phytoene synthase activity performed by the bifunctional enzyme al-2 first produces phytoene from geranyl-geranyl pyrophosphate (GGPP). The phytoene dehydrogenase al-1 then introduces 5 desaturations to lead to 3,4-didehydrolycopene via the intermediates phytofluene, zeta-carotene, neurosporene and lycopene. Al-2 cyclase activity then converts 3,4-didehydrolycopene into torulene. Al-2 can also convet lycopene into gamma-carotene which in turn is converted to beta-carotene by an additional al-2 cyclization reaction. Torulene is the substrate of the dioxidase cao-2 that breaks the molecule, removing five carbon atoms to yield beta-apo-4'-carotenal, whereas the aldehyde dehydrogenase ylo-1 mediates the last step by converting beta-apo-4'-carotenal into neurosporaxanthin (Probable).
messages: Is not regulated by light unlike the genes responsible for the preceding reactions in the carotenoid pathway.

367110:NCU02319
gene id: 367110:NCU02319
uniprot id: Q7S416
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

367110:NCU09020
gene id: 367110:NCU09020
uniprot id: Q7S2V5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
messages: Membrane

367110:NCU03998
gene id: 367110:NCU03998
uniprot id: Q7RZK0
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

367110:NCU10675
gene id: 367110:NCU10675
uniprot id: A7UWS5
names: Subcellular Location Annotation
messages: Membrane

367110:NCU01504
gene id: 367110:NCU01504
uniprot id: Q1K5K7
names: Similarity
messages: Belongs to the RCAN family.

367110:NCU08699
gene id: 367110:NCU08699
uniprot id: Q92247
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: By blue light.
messages: May play a role as an NAD-dependent dehydrogenase in the mitochondria.
messages: Mitochondrion

367110:NCU02611
gene id: 367110:NCU02611
uniprot id: Q7SG09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM MRD1 family.
messages: Involved in pre-rRNA processing.
messages: Nucleus

367110:NCU05585
gene id: 367110:NCU05585
uniprot id: Q7S6X8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU10852
gene id: 367110:NCU10852
uniprot id: V5IPM4
uniprot id: V5IR34
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

367110:NCU02754
gene id: 367110:NCU02754
uniprot id: Q8TG11
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Phosphorylated by alpha subunit.
messages: Regulatory subunit of casein kinase II/CK2 (By similarity). As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (By similarity).
messages: Tetramer composed of two alpha chains, one beta chain and one beta' chain.

367110:NCU09510
gene id: 367110:NCU09510
uniprot id: Q7S1Q5
names: Function
names: Similarity
messages: Belongs to the PIGL family.
messages: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.

367110:NCU10007
gene id: 367110:NCU10007
uniprot id: P28345
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the malate synthase family.
messages: Glyoxysome

367110:NCU05548
gene id: 367110:NCU05548
uniprot id: Q7S715
names: Similarity
messages: Belongs to the class-I DAHP synthase family.

367110:NCU04726
gene id: 367110:NCU04726
uniprot id: Q7S6H8
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

367110:NCU08706
gene id: 367110:NCU08706
uniprot id: Q1K8W2
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

367110:NCU05281
gene id: 367110:NCU05281
uniprot id: Q7S8K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EAF7 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
messages: Nucleus

367110:NCU02134
gene id: 367110:NCU02134
uniprot id: Q7SE42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LCL3 family.
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion

367110:NCU04486
gene id: 367110:NCU04486
uniprot id: V5IMC0
uniprot id: V5IP27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

367110:NCU09738
gene id: 367110:NCU09738
uniprot id: Q7SEI7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-ketoglutarate-dependent xanthine dioxygenase is a non-heme mononuclear Fe(2+) enzyme that decarboxylates alpha-ketoglutarate to succinate and CO(2) while hydroxylating xanthine to generate uric acid (PubMed:15948966). Allows xanthine utilization as a nitrogen source (PubMed:15948966).
messages: Belongs to the TfdA dioxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: cytosol

367110:NCU08880
gene id: 367110:NCU08880
uniprot id: Q7S756
names: Similarity
messages: Belongs to the amino acid/polyamine transporter 2 family.

367110:NCU09880
gene id: 367110:NCU09880
uniprot id: Q7S234
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

367110:NCU10721
gene id: 367110:NCU10721
uniprot id: A7UWQ9
names: Subcellular Location Annotation
messages: Membrane

367110:NCU07334
gene id: 367110:NCU07334
uniprot id: Q7SA29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

367110:NCU05601
gene id: 367110:NCU05601
uniprot id: P14187
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Mitochondrion inner membrane

367110:NCU03166
gene id: 367110:NCU03166
uniprot id: Q1K910
names: Similarity
messages: Belongs to the SAICAR synthetase family.

367110:NCU00324
gene id: 367110:NCU00324
uniprot id: Q7RZP0
names: Similarity
messages: Belongs to the SIN1 family.

367110:NCU03228
gene id: 367110:NCU03228
uniprot id: Q7SGU1
names: Subcellular Location Annotation
messages: Membrane

367110:NCU08886
gene id: 367110:NCU08886
uniprot id: Q1K6A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Secreted

367110:NCU08021
gene id: 367110:NCU08021
uniprot id: Q7SAM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.

367110:NCU00406
gene id: 367110:NCU00406
uniprot id: Q7RYQ4
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

367110:NCU04325
gene id: 367110:NCU04325
uniprot id: Q1K715
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

367110:NCU05937
gene id: 367110:NCU05937
uniprot id: Q7S2E1
names: Function
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.
messages: Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.

367110:NCU05238
gene id: 367110:NCU05238
uniprot id: Q7S8U6
names: Similarity
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

367110:NCU07929
gene id: 367110:NCU07929
uniprot id: Q7S9Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

367110:NCU03258
gene id: 367110:NCU03258
uniprot id: Q7RW03
names: Similarity
messages: Belongs to the OSBP family.

367110:NCU07500
gene id: 367110:NCU07500
uniprot id: Q7SG42
names: Similarity
messages: Belongs to the PGA52 family.

367110:NCU09098
gene id: 367110:NCU09098
uniprot id: Q7SFQ2
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03809
gene id: 367110:NCU03809
uniprot id: Q9HED8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

367110:NCU07494
gene id: 367110:NCU07494
uniprot id: Q7SG48
names: Function
names: Similarity
messages: Belongs to the RRF family.
messages: Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.

367110:NCU00025
gene id: 367110:NCU00025
uniprot id: Q7RY80
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03905
gene id: 367110:NCU03905
uniprot id: F5HEL0
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

367110:NCU01636
gene id: 367110:NCU01636
uniprot id: F5HD81
names: Similarity
messages: Belongs to the GST superfamily. Kappa family.

367110:NCU05712
gene id: 367110:NCU05712
uniprot id: Q7SBA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Cytoplasm
messages: Gasdermin-like protein involved in heterokaryon incompatibility, a process that ensures that during spontaneous vegetative cell fusion, only compatible cells from the same colony survive (non-self-recognition) (PubMed:31636083, PubMed:32703806). In N.crassa, the rcd-1 locus exists as 2 incompatible alleles, rcd-1-1 (this entry) and rcd-1-2 (AC P0DW10) (PubMed:31636083). During the allorecognition process, forms a heterooligomer with rcd-1-2, thereby forming a functional gasdermin-like complex that binds to membranes and forms pores, triggering cell death (PubMed:32703806). Binds negatively charged phospholipids, such as cardiolipin and phosphatidylserine (PubMed:32703806). Also binds to phosphoinositides, preferentially to phosphatidylinositol-3-phosphate (PtdIns-3-P), PtdIns-5-P and PtdIns-3,5-P2 (PubMed:32703806).
messages: Heterooligomer; the heterooligomer with rcd-1-2 forms a ring-shaped pore complex when inserted in the membrane.

367110:NCU03669
gene id: 367110:NCU03669
uniprot id: Q9P6V8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
messages: Component of the nucleolar and nucleoplasmic pre-60S ribosomal particle.
messages: Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

367110:NCU06613
gene id: 367110:NCU06613
uniprot id: Q7S9Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Membrane

367110:NCU06895
gene id: 367110:NCU06895
uniprot id: Q7S3F8
names: Similarity
messages: Belongs to the cytochrome P450 family.

367110:NCU12154
gene id: 367110:NCU12154
uniprot id: V5INJ3
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

367110:NCU09218
gene id: 367110:NCU09218
uniprot id: V5IQ81
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

367110:NCU06869
gene id: 367110:NCU06869
uniprot id: V5IKS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Nucleus

367110:NCU01914
gene id: 367110:NCU01914
uniprot id: Q7SH92
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Prevacuolar compartment membrane
messages: Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity).
messages: The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.

367110:NCU07843
gene id: 367110:NCU07843
uniprot id: Q7SBW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNF8 family.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).

367110:NCU00441
gene id: 367110:NCU00441
uniprot id: Q7RXR8
names: Similarity
messages: Belongs to the phosducin family.

367110:NCU07232
gene id: 367110:NCU07232
uniprot id: Q7RW96
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

367110:NCU04074
gene id: 367110:NCU04074
uniprot id: P23710
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Complex I is composed of about 40 different subunits. This is a component of the iron-sulfur protein fraction.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Mitochondrion inner membrane

367110:NCU07863
gene id: 367110:NCU07863
uniprot id: Q7SBU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF1 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).
messages: Component of the NuA4 histone acetyltransferase complex.
messages: Nucleus

367110:NCU01146
gene id: 367110:NCU01146
uniprot id: Q1K756
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAP-alpha family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU02380
gene id: 367110:NCU02380
uniprot id: V5IKE8
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

367110:NCU02354
gene id: 367110:NCU02354
uniprot id: Q7S4X1
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU03800
gene id: 367110:NCU03800
uniprot id: Q1K7H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

367110:NCU16013
gene id: 367110:NCU16013
uniprot id: Q35128
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme b groups non-covalently per subunit.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (cob), cytochrome c1 (cyt-1) and Rieske protein (fes-1), 2 core protein subunits pep and ucr-1, and 5 low-molecular weight protein subunits qcr6, qcr7, qcr8, qcr9 and probably NCU16844/qcr10 (PubMed:226365, PubMed:6273583, PubMed:18251112, PubMed:6302289). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplexes SCI(1)III(2), SCIII(2)IV(1) and SCIII(2)IV(2) as well as higher order I(x)III(y)IV(z) megacomplexes) (PubMed:17873079, PubMed:19239619).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (PubMed:3015618) (Probable). Cytochrome b is a catalytic core subunit containing 2 b-type hemes BL and BH topographically segregated in the quinone reduction (Qi) and quinol oxidation (Q0) sites on opposite sides of the membrane (By similarity).
messages: Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.
messages: Mitochondrion inner membrane

367110:NCU02349
gene id: 367110:NCU02349
uniprot id: Q7S407
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

367110:NCU02370
gene id: 367110:NCU02370
uniprot id: Q7S4V6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RSA3 family.
messages: Required for efficient biogenesis of the 60S ribosomal subunit.
messages: nucleolus

367110:NCU00128
gene id: 367110:NCU00128
uniprot id: Q7RWW4
names: Subcellular Location Annotation
messages: Membrane

367110:NCU09023
gene id: 367110:NCU09023
uniprot id: Q7S2V2
names: Similarity
messages: Belongs to the multicopper oxidase family.

367110:NCU03662
gene id: 367110:NCU03662
uniprot id: Q1K6P6
names: Similarity
messages: Belongs to the XPG/RAD2 endonuclease family.

367110:NCU01587
gene id: 367110:NCU01587
uniprot id: V5IPJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family.
messages: Nucleus matrix
messages: cytoskeleton

367110:NCU03675
gene id: 367110:NCU03675
uniprot id: Q7S7Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SCAP family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

367110:NCU09534
gene id: 367110:NCU09534
uniprot id: Q7S060
names: Similarity
messages: Belongs to the glutathione peroxidase family.

367110:NCU01337
gene id: 367110:NCU01337
uniprot id: Q1K7T9
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

367110:NCU01745
gene id: 367110:NCU01745
uniprot id: Q1K5R9
names: Subcellular Location Annotation
messages: Membrane
messages: Vacuole membrane

367110:NCU05686
gene id: 367110:NCU05686
uniprot id: Q7SBQ2
names: Similarity
messages: Belongs to the glycosyl hydrolase 16 family.

367110:NCU03441
gene id: 367110:NCU03441
uniprot id: Q96U88
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PROPPIN family.
messages: Component of the PI(3,5)P2 regulatory complex.
messages: Endosome membrane
messages: Preautophagosomal structure membrane
messages: The L/FRRG motif is essential for the cytoplasm to vacuole transport (Cvt) pathway, for the recruitment of apg-6/atg8 and atg16 to the PAS in nutrient-rich medium, and for its recruitment to and dissociation from the PAS under starvation conditions.
messages: The N-terminus might form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane.
messages: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct apg-7/atg9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).
messages: Vacuole membrane

367110:NCU02405
gene id: 367110:NCU02405
uniprot id: Q7S479
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP14 family.
messages: Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
messages: Cytoplasm

367110:NCU09461
gene id: 367110:NCU09461
uniprot id: Q7SC18
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

367110:NCU06358
gene id: 367110:NCU06358
uniprot id: Q7S9U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU06996
gene id: 367110:NCU06996
uniprot id: Q7SAF4
names: Similarity
messages: Belongs to the hexokinase family.

367110:NCU05113
gene id: 367110:NCU05113
uniprot id: Q7RYF6
names: Similarity
messages: Belongs to the multicopper oxidase family.

367110:NCU00418
gene id: 367110:NCU00418
uniprot id: P42114
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. The precise function of this subunit is unknown but believed to be important.
messages: Belongs to the complex I LYR family.
messages: Complex I is composed of about 40 different subunits. Belongs to the peripheral arm of the complex, most likely the globular part.
messages: Mitochondrion inner membrane

367110:NCU09212
gene id: 367110:NCU09212
uniprot id: V5IR71
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

367110:NCU03783
gene id: 367110:NCU03783
uniprot id: Q1K7A0
names: Similarity
messages: Belongs to the amino acid/polyamine transporter 2 family.

367110:NCU16631
gene id: 367110:NCU16631
uniprot id: U9W814
names: Subcellular Location Annotation
messages: Membrane
messages: Preautophagosomal structure membrane

367110:NCU06231
gene id: 367110:NCU06231
uniprot id: Q7SBS4
names: Similarity
messages: Belongs to the amino acid/polyamine transporter 2 family.

367110:NCU08345
gene id: 367110:NCU08345
uniprot id: V5IQU5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

367110:NCU08119
gene id: 367110:NCU08119
uniprot id: Q7SD07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Nucleus

367110:NCU07842
gene id: 367110:NCU07842
uniprot id: U9W2P7
uniprot id: U9W802
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Cell septum
messages: Impairs the recruitment of hex-1 assemblies to the matrix face of the peroxisome membrane, and the subsequent production of Woronin bodies.
messages: Membrane
messages: Peroxisome membrane
messages: Self-assembles into detergent-resistant oligomers and forms a complex with hex-1 assemblies.
messages: Woronin sorting complex protein involved in both Woronin bodies (WB) formation and inherence (PubMed:18227279). Localizes to large peroxisome membranes where it self-assembles into detergent-resistant oligomers that envelop hex-1 assemblies, producing asymmetrical nascent WBs (PubMed:18227279). These structures are then delivered to the cell cortex, which permits partitioning of the nascent WB and WB inheritance (PubMed:18227279).

367110:NCU09436
gene id: 367110:NCU09436
uniprot id: Q7S1X9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ASF1 family.
messages: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.
messages: Interacts with histone H3 and histone H4.
messages: Nucleus

367110:NCU01162
gene id: 367110:NCU01162
uniprot id: Q1K868
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.

367110:NCU02943
gene id: 367110:NCU02943
uniprot id: Q874C1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM50 family.
messages: Component of the TIM23 complex, at least composed of tim23, tim17, tim50 and tim21 (Probable). Interacts with preproteins in transit (By similarity).
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein tim23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex.
messages: Mitochondrion inner membrane

367110:NCU02373
gene id: 367110:NCU02373
uniprot id: P25284
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA9 subunit family.
messages: Binds 1 FAD per subunit.
messages: Complex I is composed of about 40 different subunits.
messages: Mitochondrion matrix

367110:NCU02550
gene id: 367110:NCU02550
uniprot id: Q7SHR5
names: Similarity
messages: Belongs to the glycosyl hydrolases 36 family.

367110:NCU07717
gene id: 367110:NCU07717
uniprot id: Q7S8S2
names: Similarity
messages: Belongs to the replication factor A protein 2 family.

367110:NCU07365
gene id: 367110:NCU07365
uniprot id: Q7S0B8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

367110:NCU09529
gene id: 367110:NCU09529
uniprot id: Q7S0I0
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU06672
gene id: 367110:NCU06672
uniprot id: Q871U2
uniprot id: V5IN70
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG7 family.
messages: Cytoplasm
messages: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.
messages: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates atg12 for its conjugation with apg-4/atg5 and apg-6/atg8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the apg-6/atg8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity (By similarity).
messages: Homodimer.
messages: Preautophagosomal structure
messages: The GxGxxG motif is important for the function, possibly through binding with ATP.

367110:NCU02633
gene id: 367110:NCU02633
uniprot id: Q7SDH7
names: Similarity
messages: Belongs to the HTATSF1 family.

367110:NCU05720
gene id: 367110:NCU05720
uniprot id: Q7SB92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CHS7 family.
messages: Chaperone required for the export of the chitin synthase chs-3 from the endoplasmic reticulum.
messages: Endoplasmic reticulum membrane
messages: Interacts with chs-3.

367110:NCU03995
gene id: 367110:NCU03995
uniprot id: Q7RXI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST3/OST6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU00405
gene id: 367110:NCU00405
uniprot id: Q7RYQ5
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

367110:NCU09318
gene id: 367110:NCU09318
uniprot id: Q7SDF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.
messages: Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.
messages: Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.
messages: Nucleus

367110:NCU00153
gene id: 367110:NCU00153
uniprot id: Q7RXQ5
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

367110:NCU03405
gene id: 367110:NCU03405
uniprot id: Q1K5F6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex DAD1 family.
messages: Nucleus
messages: kinetochore
messages: spindle

367110:NCU09043
gene id: 367110:NCU09043
uniprot id: Q7S2T2
names: Similarity
messages: Belongs to the caleosin family.

367110:NCU03209
gene id: 367110:NCU03209
uniprot id: Q7SGW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.
messages: Secreted

367110:NCU00103
gene id: 367110:NCU00103
uniprot id: Q7RYM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL67 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (Probable). mL67/MHR1 also has extraribosomal functions, being involved in regulation of mitochondrial DNA recombination, maintenance and repair, and generation of homoplasmic cells. mL67/MHR1 also acts as transcription factor involved in regulation of RNA polymerase II-dependent transcription (By similarity).
messages: Mitochondrion

367110:NCU11348
gene id: 367110:NCU11348
uniprot id: Q7RZ09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB7 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

367110:NCU03859
gene id: 367110:NCU03859
uniprot id: Q7RW75
names: Similarity
messages: Belongs to the MYG1 family.

367110:NCU04787
gene id: 367110:NCU04787
uniprot id: Q7S6P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AATF family.
messages: nucleolus

367110:NCU01669
gene id: 367110:NCU01669
uniprot id: Q1K5I1
names: Subcellular Location Annotation
messages: Cytoplasm

367110:NCU02419
gene id: 367110:NCU02419
uniprot id: Q7S4E0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins. uS17m interacts with the F(1)-ATPase inhibitor IF(1) dimer.
messages: Mitochondrion

367110:NCU08742
gene id: 367110:NCU08742
uniprot id: Q7SCF3
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU07619
gene id: 367110:NCU07619
uniprot id: Q7SB35
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

367110:NCU08316
gene id: 367110:NCU08316
uniprot id: Q7SA72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

367110:NCU04076
gene id: 367110:NCU04076
uniprot id: Q7RZE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane

367110:NCU08960
gene id: 367110:NCU08960
uniprot id: Q7S796
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: P1 and P2 exist as dimers at the large ribosomal subunit.

367110:NCU07116
gene id: 367110:NCU07116
uniprot id: Q7S659
names: Function
names: Similarity
messages: Belongs to the MUB1/samB family.
messages: Involved in determination of the onset of polarized growth and morphogenesis. Plays a role in the regulation of branching in hyphae and spore formation.

367110:NCU09775
gene id: 367110:NCU09775
uniprot id: Q7S187
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 54 family.
messages: Secreted

367110:NCU05781
gene id: 367110:NCU05781
uniprot id: Q7S5R2
names: Similarity
messages: Belongs to the MAD2 family.

367110:NCU07453
gene id: 367110:NCU07453
uniprot id: Q7SF02
names: Similarity
messages: Belongs to the peptidase C15 family.

367110:NCU05708
gene id: 367110:NCU05708
uniprot id: Q7SBN0
names: Similarity
messages: Belongs to the PheA/TfdB FAD monooxygenase family.

367110:NCU01912
gene id: 367110:NCU01912
uniprot id: V5IP53
uniprot id: V5IRE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU03177
gene id: 367110:NCU03177
uniprot id: Q7SEV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCO1/2 family.
messages: Mitochondrion inner membrane

367110:NCU05389
gene id: 367110:NCU05389
uniprot id: Q1K8S5
names: Similarity
messages: Belongs to the peptidase C48 family.

367110:NCU00786
gene id: 367110:NCU00786
uniprot id: Q7SFU4
names: Subcellular Location Annotation
messages: Membrane

367110:NCU05418
gene id: 367110:NCU05418
uniprot id: P49365
names: Function
names: Similarity
names: Subunit
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
messages: Homotetramer.

367110:NCU09458
gene id: 367110:NCU09458
uniprot id: V5IL88
names: Subcellular Location Annotation
messages: Membrane

367110:NCU17009
gene id: 367110:NCU17009
uniprot id: V5IML7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNUT3 family.
messages: May play a role in mRNA splicing.
messages: Nucleus
messages: Part of a tri-snRNP complex.

367110:NCU10169
gene id: 367110:NCU10169
uniprot id: A7UXA6
names: Similarity
messages: Belongs to the TACO1 family.

367110:NCU08278
gene id: 367110:NCU08278
uniprot id: Q7S8I9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

367110:NCU06090
gene id: 367110:NCU06090
uniprot id: Q7S482
names: Similarity
messages: Belongs to the SURF6 family.

367110:NCU09101
gene id: 367110:NCU09101
uniprot id: Q7SFP9
names: Subcellular Location Annotation
messages: Membrane

367110:NCU16902
gene id: 367110:NCU16902
uniprot id: V5IN55
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU01441
gene id: 367110:NCU01441
uniprot id: Q1K4R6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

367110:NCU09094
gene id: 367110:NCU09094
uniprot id: Q7SFQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPI1/TEX10 family.
messages: Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.
messages: Component of the RIX1 complex, composed of rrm-9/ipi1, rix1/ipi2 and ipi3 in a 1:2:2 stoichiometry. The complex interacts (via rix1) with mdn1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.
messages: Nucleus

367110:NCU07024
gene id: 367110:NCU07024
uniprot id: Q96TL5
names: Activity Regulation
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Activated by tyrosine and threonine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.
messages: Cytoplasm
messages: Dually phosphorylated on Thr-171 and Tyr-173, which activates the enzyme (By similarity). Phosphorylation is induced by fungicides and osmotic stress.
messages: Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Involved in ion flux-mediated turgor regulation.
messages: Nucleus
messages: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

367110:NCU04648
gene id: 367110:NCU04648
uniprot id: V5INQ7
names: Similarity
messages: In the C-terminal section; belongs to the NAD synthetase family.

367110:NCU01172
gene id: 367110:NCU01172
uniprot id: Q1K861
names: Similarity
messages: Belongs to the VPS54 family.

367110:NCU00549
gene id: 367110:NCU00549
uniprot id: Q7SF99
names: Similarity
messages: Belongs to the GST superfamily.

367110:NCU01506
gene id: 367110:NCU01506
uniprot id: Q9P5T3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRG9 family.
messages: Mitochondrion
messages: Required for respiratory activity and maintenance and expression of the mitochondrial genome.

367110:NCU02578
gene id: 367110:NCU02578
uniprot id: V5IRH1
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU07324
gene id: 367110:NCU07324
uniprot id: P19463
names: Developmental Stage
messages: Expressed early during conidial (dormant spores) differentiation.

367110:NCU04990
gene id: 367110:NCU04990
uniprot id: Q7S031
names: Similarity
messages: Belongs to the protein kinase superfamily.

367110:NCU03876
gene id: 367110:NCU03876
uniprot id: Q7RXH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

367110:NCU00334
gene id: 367110:NCU00334
uniprot id: Q7RZN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: Cytoplasm
messages: nucleolus

367110:NCU07465
gene id: 367110:NCU07465
uniprot id: V5IPW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

367110:NCU03255
gene id: 367110:NCU03255
uniprot id: Q7SEH2
names: Similarity
messages: Belongs to the histidine acid phosphatase family.

367110:NCU02747
gene id: 367110:NCU02747
uniprot id: Q7SGA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMCO4 family.
messages: Membrane

367110:NCU01929
gene id: 367110:NCU01929
uniprot id: Q7SDP4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. PAN3 family.
messages: Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro (PubMed:23932717). The nucleotide-binding site is juxtaposed to the RNase active site of par-1/pan2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs (By similarity).
messages: Cytoplasm
messages: Homodimer. Forms a heterotrimer with a catalytic subunit par-1/pan2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein pabp-1 (via PABC domain), conferring substrate specificity of the enzyme complex.
messages: Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pabp-1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by rgb-30/xrn1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. par-2/pan3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit par-1/pan2 to mRNA via its interaction with RNA and with pabp-1.
messages: The N-terminal zinc finger binds to poly(A) RNA.
messages: The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for par-1/pan2.

367110:NCU00298
gene id: 367110:NCU00298
uniprot id: Q7RZR6
names: Subcellular Location Annotation
messages: Membrane

367110:NCU04952
gene id: 367110:NCU04952
uniprot id: Q7S3R5
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

367110:NCU07544
gene id: 367110:NCU07544
uniprot id: Q7S304
uniprot id: U9W8V7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRE1 family.
messages: E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.
messages: Nucleus

367110:NCU02412
gene id: 367110:NCU02412
uniprot id: V5IL02
uniprot id: V5IMI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WHI5/NRM1 family.
messages: Cytoplasm
messages: Nucleus

367110:NCU01826
gene id: 367110:NCU01826
uniprot id: Q1K581
names: Subcellular Location Annotation
messages: Membrane

367110:NCU09897
gene id: 367110:NCU09897
uniprot id: Q7S202
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.

367110:NCU03813
gene id: 367110:NCU03813
uniprot id: Q07103
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.
messages: Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.
messages: Cytoplasm
messages: Developmentally regulated. Expressed only during conidiation and early germination.
messages: Homodimer.

367110:NCU03802
gene id: 367110:NCU03802
uniprot id: Q96UB1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-BBH/TMLD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).
messages: Cytoplasm

367110:NCU08416
gene id: 367110:NCU08416
uniprot id: Q7SC38
names: Similarity
messages: Belongs to the SDHAF4 family.

367110:NCU08985
gene id: 367110:NCU08985
uniprot id: Q7S2Y4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

367110:NCU01511
gene id: 367110:NCU01511
uniprot id: Q1K5K4
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.

367110:NCU01179
gene id: 367110:NCU01179
uniprot id: P24391
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tom40 family.
messages: Channel-forming protein essential for import of protein precursors into mitochondria.
messages: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 8 different proteins (tom5, tom6, tom7, tom20, tom22, tom37, tom40 and tom70). Interacts with mitochondrial targeting sequences.
messages: Mitochondrion outer membrane

367110:NCU00272
gene id: 367110:NCU00272
uniprot id: Q7RZU1
names: Similarity
messages: Belongs to the cullin family.

367110:NCU07360
gene id: 367110:NCU07360
uniprot id: Q7S0P9
names: Similarity
messages: Belongs to the HscB family.

367110:NCU04256
gene id: 367110:NCU04256
uniprot id: Q1K7I8
names: Similarity
messages: Belongs to the IFRD family.

367110:NCU05655
gene id: 367110:NCU05655
uniprot id: Q7SAU4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
messages: telomere

367110:NCU08616
gene id: 367110:NCU08616
uniprot id: O74633
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).
messages: nucleolus

367110:NCU07141
gene id: 367110:NCU07141
uniprot id: Q7S6B1
names: Similarity
messages: Belongs to the glycosyltransferase 34 family.
messages: Belongs to the glycosyltransferase 77 family.

367110:NCU06142
gene id: 367110:NCU06142
uniprot id: Q7S5E6
names: Function
messages: Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.

367110:NCU04092
gene id: 367110:NCU04092
uniprot id: Q7RWL7
names: Similarity
messages: Belongs to the amidase family.

367110:NCU05752
gene id: 367110:NCU05752
uniprot id: Q7S4S0
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

367110:NCU09874
gene id: 367110:NCU09874
uniprot id: Q7S240
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

367110:NCU08579
gene id: 367110:NCU08579
uniprot id: Q7S020
names: Similarity
messages: Belongs to the peptidase C19 family.

367110:NCU01856
gene id: 367110:NCU01856
uniprot id: Q7SHF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

367110:NCU07966
gene id: 367110:NCU07966
uniprot id: Q7S919
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.

367110:NCU03771
gene id: 367110:NCU03771
uniprot id: Q7RVU1
names: Similarity
messages: Belongs to the polyprenol kinase family.

367110:NCU08228
gene id: 367110:NCU08228
uniprot id: Q7S3L5
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

367110:NCU02916
gene id: 367110:NCU02916
uniprot id: Q7SHI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 61 family.
messages: Secreted

367110:NCU05733
gene id: 367110:NCU05733
uniprot id: P78704
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Probable transcriptional regulator.

367110:NCU00875
gene id: 367110:NCU00875
uniprot id: Q7SFF6
names: Subcellular Location Annotation
messages: Membrane

367110:NCU00007
gene id: 367110:NCU00007
uniprot id: Q7RY98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the palH/RIM21 family.
messages: Cell membrane
messages: Required for the proteolytic cleavage of the transcription factor pacc-1 in response to alkaline ambient pH.

367110:NCU00673
gene id: 367110:NCU00673
uniprot id: Q7SHY0
names: Similarity
messages: Belongs to the peptidase S8 family.

367110:NCU00194
gene id: 367110:NCU00194
uniprot id: U9W8E1
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

367110:NCU03475
gene id: 367110:NCU03475
uniprot id: Q1K511
names: Similarity
messages: Belongs to the aegerolysin family.

367110:NCU10777
gene id: 367110:NCU10777
uniprot id: A7UX90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.
messages: Cytoplasm
messages: Nucleus

367110:NCU07264
gene id: 367110:NCU07264
uniprot id: Q7S951
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

367110:NCU09516
gene id: 367110:NCU09516
uniprot id: Q7S1P9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Cytoplasm
messages: Nucleus
messages: Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein uvs-2/rad18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity).

367110:NCU10351
gene id: 367110:NCU10351
uniprot id: A7UXB4
names: Similarity
messages: Belongs to the pyridoxine kinase family.

367110:NCU04063
gene id: 367110:NCU04063
uniprot id: Q7RZF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SEC13 family.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Nup-20/sec13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution (By similarity).
messages: Endoplasmic reticulum membrane
messages: The COPII coat is composed of at least 5 proteins: the sec23/24 complex, the sec13/31 complex, and the protein vtr-7/sar1. Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.
messages: nuclear pore complex

367110:NCU16506
gene id: 367110:NCU16506
uniprot id: V5IN78
names: Similarity
messages: Belongs to the IUNH family.

367110:NCU00359
gene id: 367110:NCU00359
uniprot id: Q7RZK7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YAF9 family.
messages: Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.
messages: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity).
messages: Cytoplasm
messages: Nucleus
messages: The coiled-coil domain is required for assembly into the NuA4 complex.

367110:NCU07057
gene id: 367110:NCU07057
uniprot id: Q7S5W0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU00837
gene id: 367110:NCU00837
uniprot id: Q7SCJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

367110:NCU00477
gene id: 367110:NCU00477
uniprot id: Q7RXW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S10 family.
messages: Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate (By similarity).
messages: Vacuole

367110:NCU00517
gene id: 367110:NCU00517
uniprot id: Q7SE56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad17/RAD24 family.
messages: Nucleus

367110:NCU03908
gene id: 367110:NCU03908
uniprot id: Q9P5L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMP52 family.
messages: Mitochondrion outer membrane

367110:NCU05027
gene id: 367110:NCU05027
uniprot id: Q7RX61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM24 family.
messages: Mitochondrion

367110:NCU01650
gene id: 367110:NCU01650
uniprot id: Q7RWZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL61 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU06444
gene id: 367110:NCU06444
uniprot id: Q7RYX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

367110:NCU07659
gene id: 367110:NCU07659
uniprot id: P20285
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion matrix
messages: The E2 component contains covalently-bound lipoyl cofactors and it participates in the generation of acetyl groups from hydroxyethyl-thiamine pyrophosphate-E1 and their transfer to coenzyme A.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
messages: Was originally thought to be a ribosomal protein.

367110:NCU16651
gene id: 367110:NCU16651
uniprot id: U9W889
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

367110:NCU06222
gene id: 367110:NCU06222
uniprot id: Q7SBT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosyl-DNA phosphodiesterase family.
messages: Nucleus

367110:NCU16010
gene id: 367110:NCU16010
uniprot id: Q35135
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Encoded from partially processed ndh-5 mRNA that terminates with the in-frame coding sequence of the first intron.
messages: In the C-terminal section; belongs to the LAGLIDADG endonuclease family.
messages: In the N-terminal section; belongs to the complex I subunit 5 family.
messages: Mitochondrial DNA endonuclease involved in intron homing.
messages: Mitochondrion membrane

367110:NCU02583
gene id: 367110:NCU02583
uniprot id: V5IP80
uniprot id: V5IPD3
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

367110:NCU01127
gene id: 367110:NCU01127
uniprot id: F5HG10
names: Similarity
messages: Belongs to the Gfa family.

367110:NCU00466
gene id: 367110:NCU00466
uniprot id: Q7RXX9
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).

367110:NCU02247
gene id: 367110:NCU02247
uniprot id: Q3Y3Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
messages: Nucleus

367110:NCU01147
gene id: 367110:NCU01147
uniprot id: F5HAE7
names: Similarity
messages: Belongs to the group II decarboxylase family.

367110:NCU00037
gene id: 367110:NCU00037
uniprot id: Q7RY68
uniprot id: U9W2Z7
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Required for 3'-end cleavage and polyadenylation of pre-mRNAs.
messages: Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle (By similarity).

367110:NCU08615
gene id: 367110:NCU08615
uniprot id: Q7SFK3
names: Similarity
messages: Belongs to the tyrosinase family.

367110:NCU06585
gene id: 367110:NCU06585
uniprot id: Q7S8M9
names: Similarity
messages: Belongs to the XPC family.

367110:NCU01666
gene id: 367110:NCU01666
uniprot id: Q1K5I3
names: Similarity
messages: Belongs to the acetolactate synthase small subunit family.

367110:NCU08128
gene id: 367110:NCU08128
uniprot id: Q7S4K3
names: Similarity
messages: Belongs to the cytochrome P450 family.

367110:NCU05887
gene id: 367110:NCU05887
uniprot id: Q7S521
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

367110:NCU05876
gene id: 367110:NCU05876
uniprot id: Q7S532
names: Function
names: Similarity
names: Subunit
messages: Belongs to the palA/RIM20 family.
messages: Interacts with pacc-1 by binding to its two YPX[LI] motifs.
messages: Required for the proteolytic cleavage of the transcription factor pacc-1 in response to alkaline ambient pH. May act as a scaffold protein that recruits the calpain-like protease palB/cpr-8 via snf7/vps-3 to its substrate pacc-1 (By similarity).

367110:NCU07382
gene id: 367110:NCU07382
uniprot id: V5IPU9
uniprot id: V5IQ99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: Nucleus

367110:NCU02837
gene id: 367110:NCU02837
uniprot id: Q7RUW6
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU04347
gene id: 367110:NCU04347
uniprot id: V5IMQ4
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

367110:NCU05394
gene id: 367110:NCU05394
uniprot id: Q1K8S1
names: Subcellular Location Annotation
messages: Membrane

367110:NCU01021
gene id: 367110:NCU01021
uniprot id: Q9P748
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit F family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

367110:NCU06066
gene id: 367110:NCU06066
uniprot id: Q7S4Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS37 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Mitochondrion

367110:NCU03004
gene id: 367110:NCU03004
uniprot id: Q1K937
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

367110:NCU01606
gene id: 367110:NCU01606
uniprot id: Q9P602
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity).
messages: Mitochondrion
messages: Mitochondrion inner membrane

367110:NCU07319
gene id: 367110:NCU07319
uniprot id: Q7SA43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat COPB2 family.
messages: COPI-coated vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

367110:NCU05836
gene id: 367110:NCU05836
uniprot id: Q7S5K7
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

367110:NCU01814
gene id: 367110:NCU01814
uniprot id: Q1K536
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CHS7 family.
messages: Membrane

367110:NCU04100
gene id: 367110:NCU04100
uniprot id: Q7S7H9
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

367110:NCU09484
gene id: 367110:NCU09484
uniprot id: Q7SBZ9
names: Similarity
messages: Belongs to the peptidase A1 family.

367110:NCU16771
gene id: 367110:NCU16771
uniprot id: V5INT5
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

367110:NCU16454
gene id: 367110:NCU16454
uniprot id: V5IQ80
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU03646
gene id: 367110:NCU03646
uniprot id: V5ILD0
uniprot id: V5INT7
names: Similarity
messages: Belongs to the peroxidase family.

367110:NCU00173
gene id: 367110:NCU00173
uniprot id: Q7RXB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the esterase D family.
messages: Cytoplasm
messages: Serine hydrolase involved in the detoxification of formaldehyde.

367110:NCU03276
gene id: 367110:NCU03276
uniprot id: V5IQR2
uniprot id: V5IRL5
names: Similarity
messages: Belongs to the polyketide transferase af380 family.

367110:NCU12023
gene id: 367110:NCU12023
uniprot id: V5ILE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Mitochondrion

367110:NCU08968
gene id: 367110:NCU08968
uniprot id: Q7S7E6
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.

367110:NCU00182
gene id: 367110:NCU00182
uniprot id: Q7RXA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LU7TM family.
messages: Membrane

367110:NCU08762
gene id: 367110:NCU08762
uniprot id: P38670
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane
messages: Reduces the C14=C15 double bond of 4,4-dimethyl-cholesta-8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol.

367110:NCU09844
gene id: 367110:NCU09844
uniprot id: Q7S0G8
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily.

367110:NCU02076
gene id: 367110:NCU02076
uniprot id: Q7SEY8
names: Function
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.
messages: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.

367110:NCU06914
gene id: 367110:NCU06914
uniprot id: Q7S3D9
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

367110:NCU07681
gene id: 367110:NCU07681
uniprot id: Q7S9M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane

367110:NCU01414
gene id: 367110:NCU01414
uniprot id: Q1K6U0
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EFG1/PHD1/stuA family.
messages: Constitutively expressed during the mycelial, conidial, and perithecial stages of the life cycle (PubMed:8913744).
messages: Destroys the ability to make protoperithecia (female organs), but does not affect male-specific functions (PubMed:8913744).
messages: Nucleus
messages: Transcription factor that regulates asexual reproduction (PubMed:8913744, PubMed:25550299). Binds the StuA-response elements (StRE) with the consensus sequence 5'-(A/T)CGCG(T/A)N(A/C)-3' at the promoters of target genes (By similarity). Required for rapid conidial germination, normal vegetative morphology, and protoperithecium formation (PubMed:8913744).

367110:NCU08374
gene id: 367110:NCU08374
uniprot id: Q7SGP1
names: Similarity
messages: Belongs to the SH3BGR family.

367110:NCU07071
gene id: 367110:NCU07071
uniprot id: Q7S6F2
names: Similarity
messages: Belongs to the CNOT9 family.

367110:NCU01041
gene id: 367110:NCU01041
uniprot id: Q1K8C3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

367110:NCU02805
gene id: 367110:NCU02805
uniprot id: Q7SEK8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DPH4 family.
messages: Cytoplasm
messages: Nucleus
messages: Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity).
messages: The DPH-type metal-binding (MB) domain can bind either zinc or iron ions.

367110:NCU05816
gene id: 367110:NCU05816
uniprot id: Q7S5M7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fungal cytochrome c oxidase subunit 7a family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 11 subunits. The complex is composed of a catalytic core of 3 subunits Cox1, Cox2 and Cox3, encoded in the mitochondrial DNA, and 8 supernumerary subunits Cox4, Cox5a/Cox5, Cox6, Cox7, Cox8, Cox7a/Cox9, Cox6b/Cox12 and Cox6a/Cox13, which are encoded in the nuclear genome (PubMed:31316820). The complex exists as a monomer or a dimer and forms respiratory supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in various different assemblies (supercomplexes I(1)IV(1), I(1)III(3)IV(2), III(2)IV(1) and III(2)IV(2) as well as larger supercomplexes of compositions like I(1)III(2)IV(5-6)) (PubMed:17873079).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of Cox2 and heme A of Cox1 to the active site in Cox1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

367110:NCU00765
gene id: 367110:NCU00765
uniprot id: O59942
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily.
messages: Membrane

367110:NCU06023
gene id: 367110:NCU06023
uniprot id: P05195
names: Function
names: Induction
names: Similarity
names: Subunit
messages: 3-dehydroquinate dehydratase; part of the qa gene cluster that mediates the catabolism of quinic acid (QA) and as such, allows the use of QA as a sole carbon source (PubMed:2525625, PubMed:126226, PubMed:143663, PubMed:6458044) (By similarity). Catalyzes the second reaction in the inducible quinic acid catabolic pathway by converting 3-dehydroquinate into 3-dehydroshikimate (PubMed:143663). The qa cluster encodes 3 inducible enymes (qa-2, qa-3 and qa-4) catalyzing the first three reactions in the catabolism of quinic acid to protocatechuic acid (also known as 3,4-Dihydroxybenzoic acid) (Probable).
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Expression is induced in the presence of quinic acid (PubMed:144915, PubMed:6458044). The quinic acid (qa) gene cluster is subject to two levels of gene control: a primary system which responds to the presence of quinic acid via the qa-1S repressor protein that blocks the qa-1F activator, and a secondary system which represses transcription of qa genes in the presence of a preferred carbon source such as glucose (PubMed:6458044, PubMed:12477937, PubMed:17597928, PubMed:19236936).
messages: Homododecamer. Adopts a ring-like structure, composed of an arrangement of two hexameric rings stacked on top of one another.

367110:NCU02743
gene id: 367110:NCU02743
uniprot id: Q7SGA7
names: Similarity
messages: Belongs to the VPS26 family.

367110:NCU09279
gene id: 367110:NCU09279
uniprot id: Q7S1M8
names: Similarity
messages: Belongs to the multicopper oxidase family.

367110:NCU11129
gene id: 367110:NCU11129
uniprot id: A7UWJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Secreted

367110:NCU06762
gene id: 367110:NCU06762
uniprot id: Q1K8S8
names: Similarity
messages: Belongs to the glycosyltransferase 34 family.

367110:NCU16399
gene id: 367110:NCU16399
uniprot id: V5IR56
names: Similarity
messages: Belongs to the YOS1 family.

367110:NCU04190
gene id: 367110:NCU04190
uniprot id: Q9HE88
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC8 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: The exocyst complex is composed of sec3, sec5, sec6, sec8, sec10, sec15, exo70 and exo84.

367110:NCU02546
gene id: 367110:NCU02546
uniprot id: Q7SHR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
messages: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
messages: nucleolus

367110:NCU00421
gene id: 367110:NCU00421
uniprot id: Q7RXT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF5 family.
messages: Nucleus

367110:NCU07542
gene id: 367110:NCU07542
uniprot id: Q7S306
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

367110:NCU08895
gene id: 367110:NCU08895
uniprot id: Q870V7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Probably involved in transport through the plasma membrane.

367110:NCU07682
gene id: 367110:NCU07682
uniprot id: Q1K8F6
uniprot id: V5INB8
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family.
messages: By histidine or arginine limitation.
messages: Inhibited by arginine.
messages: Mitochondrion
messages: N-acetylglutamate synthase involved in arginine biosynthesis.

367110:NCU02661
gene id: 367110:NCU02661
uniprot id: Q7SH68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

367110:NCU03465
gene id: 367110:NCU03465
uniprot id: Q7RWJ2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

367110:NCU05983
gene id: 367110:NCU05983
uniprot id: Q7S213
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

367110:NCU01409
gene id: 367110:NCU01409
uniprot id: Q7S7G6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FYV10 family.
messages: Belongs to the SSH4 family.
messages: Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane.
messages: Endosome membrane
messages: Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.
messages: Membrane
messages: Vacuole membrane

367110:NCU08410
gene id: 367110:NCU08410
uniprot id: Q7SC44
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL28 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU05293
gene id: 367110:NCU05293
uniprot id: Q7S905
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RRP8 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.
messages: nucleolus

367110:NCU09143
gene id: 367110:NCU09143
uniprot id: Q7S2K6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase e subunit family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

367110:NCU05240
gene id: 367110:NCU05240
uniprot id: Q7S8U5
names: Similarity
messages: Belongs to the SAP30 family.

367110:NCU05796
gene id: 367110:NCU05796
uniprot id: V5IL70
uniprot id: V5ILR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: cis-Golgi network

367110:NCU00649
gene id: 367110:NCU00649
uniprot id: Q7SI03
names: Similarity
messages: Belongs to the NAPRTase family.

367110:NCU11365
gene id: 367110:NCU11365
uniprot id: A7UX13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily.
messages: Catalyzes the conversion of hercynylcysteine sulfoxide to ergothioneine by cleaving the cysteine residue at the sulfur atom, the last step in the biosynthesis pathway of ergothioneine.
messages: Cytoplasm
messages: Nucleus

367110:NCU02511
gene id: 367110:NCU02511
uniprot id: Q7SHV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: nucleolus

367110:NCU04647
gene id: 367110:NCU04647
uniprot id: Q1K6G8
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

367110:NCU01808
gene id: 367110:NCU01808
uniprot id: P00048
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme c group covalently per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space

367110:NCU01273
gene id: 367110:NCU01273
uniprot id: V5ILB7
uniprot id: V5IMY1
names: Similarity
messages: Belongs to the taxilin family.

367110:NCU05231
gene id: 367110:NCU05231
uniprot id: Q7S8H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU00464
gene id: 367110:NCU00464
uniprot id: Q7RXY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL32 family.
messages: Component of the large ribosomal subunit (LSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

367110:NCU02104
gene id: 367110:NCU02104
uniprot id: Q7SDM9
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU06049
gene id: 367110:NCU06049
uniprot id: Q7S501
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU00512
gene id: 367110:NCU00512
uniprot id: Q7SE61
names: Similarity
messages: Belongs to the cullin family.

367110:NCU05942
gene id: 367110:NCU05942
uniprot id: Q7S2D6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

367110:NCU09838
gene id: 367110:NCU09838
uniprot id: Q7S070
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. LDAH family.
messages: Lipid droplet

367110:NCU11312
gene id: 367110:NCU11312
uniprot id: A7UWR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

367110:NCU05783
gene id: 367110:NCU05783
uniprot id: Q7S5R0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFT1 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane.
messages: Membrane

367110:NCU09930
gene id: 367110:NCU09930
uniprot id: F5HHZ0
names: Similarity
messages: In the C-terminal section; belongs to the DHPS family.

367110:NCU09933
gene id: 367110:NCU09933
uniprot id: Q7RV05
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03438
gene id: 367110:NCU03438
uniprot id: Q1K5B4
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

367110:NCU09552
gene id: 367110:NCU09552
uniprot id: Q7S2A9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the timeless family.
messages: Component of the fork protection complex (FPC) consisting of tof-1 and csm-3.
messages: Forms a fork protection complex (FPC) with csm-3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity).
messages: Nucleus

367110:NCU03281
gene id: 367110:NCU03281
uniprot id: V5IPK5
uniprot id: V5IPY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

367110:NCU07296
gene id: 367110:NCU07296
uniprot id: P38679
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.
messages: Produced preferentially in dark grown mycelia.
messages: Produced preferentially in illuminated mycelia.
messages: Protein kinase required for hyphal elongation.

367110:NCU01408
gene id: 367110:NCU01408
uniprot id: Q7S7G7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN3 family.
messages: Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity). The CSN complex is involved in the regulation of the circadian clock through its control of the stability of the SCF(FWD1) complex.
messages: Component of the COP9 signalosome (CSN) complex.
messages: Cytoplasm
messages: Nucleus

367110:NCU09998
gene id: 367110:NCU09998
uniprot id: Q7S055
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG11 family.
messages: Homodimer.
messages: Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion (By similarity).
messages: Preautophagosomal structure membrane
messages: Vacuole membrane

367110:NCU09616
gene id: 367110:NCU09616
uniprot id: Q1K8M6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

367110:NCU00357
gene id: 367110:NCU00357
uniprot id: Q7RZK9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MDM34 family.
messages: Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of mmm-1, mdm10, mdm12 and mdm34.
messages: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm34 is required for the interaction of the ER-resident membrane protein mmm-1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10.
messages: Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.
messages: Mitochondrion outer membrane
messages: The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers.

367110:NCU01249
gene id: 367110:NCU01249
uniprot id: Q1K6K3
names: Similarity
messages: Belongs to the importin alpha family.

367110:NCU01960
gene id: 367110:NCU01960
uniprot id: Q10116
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Only present in A-cells and in a/A diploid cells.
messages: Required, together with mating-type protein A-2, for efficient ascospore formation.

367110:NCU15829
gene id: 367110:NCU15829
uniprot id: Q9HEV5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homotetramer.
messages: Nucleus
messages: Transcriptional regulator that functions in sexual development; disruption of asd-4 gene results in agenesis of ascus and ascospore with macroscopically normal fruiting body formation. The GATA-type zinc finger domain binds to DNA sequences from its own promoter region.

367110:NCU05118
gene id: 367110:NCU05118
uniprot id: P78713
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).
messages: Vacuole membrane

367110:NCU04159
gene id: 367110:NCU04159
uniprot id: Q1K7K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

367110:NCU04338
gene id: 367110:NCU04338
uniprot id: Q7RX38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the histone H4 family.
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

367110:NCU06863
gene id: 367110:NCU06863
uniprot id: Q8J0U2
uniprot id: V5IM73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Chromosome
messages: Could act as an H1-type linker histone.
messages: Nucleus

367110:NCU00795
gene id: 367110:NCU00795
uniprot id: Q7SFT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Membrane

367110:NCU10763
gene id: 367110:NCU10763
uniprot id: A7UVS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

367110:NCU05890
gene id: 367110:NCU05890
uniprot id: Q7S518
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL49 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU06431
gene id: 367110:NCU06431
uniprot id: Q7RV75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Cytoplasm

367110:NCU03029
gene id: 367110:NCU03029
uniprot id: Q7SGY7
names: Similarity
messages: Belongs to the NPR2 family.

367110:NCU08132
gene id: 367110:NCU08132
uniprot id: Q7S4J9
names: Similarity
messages: Belongs to the glycosyltransferase group 1 family.

367110:NCU09873
gene id: 367110:NCU09873
uniprot id: Q7RVS9
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.

367110:NCU02591
gene id: 367110:NCU02591
uniprot id: V5IP84
uniprot id: V5IPF2
names: Subcellular Location Annotation
messages: Membrane

367110:NCU02282
gene id: 367110:NCU02282
uniprot id: Q7S586
names: Subcellular Location Annotation
messages: Membrane

367110:NCU04749
gene id: 367110:NCU04749
uniprot id: V5IKL7
uniprot id: V5IKU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Chromosome
messages: Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
messages: Nucleus

367110:NCU00377
gene id: 367110:NCU00377
uniprot id: Q7RYT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIMR family. LMBRD1 subfamily.
messages: Lysosome membrane
messages: Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors.

367110:NCU03292
gene id: 367110:NCU03292
uniprot id: Q1K905
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

367110:NCU08628
gene id: 367110:NCU08628
uniprot id: Q7SFJ3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLX4 family.
messages: Forms a heterodimer with slx1.
messages: Nucleus
messages: Phosphorylated in response to DNA damage.
messages: Regulatory subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.

367110:NCU03623
gene id: 367110:NCU03623
uniprot id: Q1K7R0
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

367110:NCU09611
gene id: 367110:NCU09611
uniprot id: Q1K8M9
names: Similarity
messages: Belongs to the fructosamine kinase family.

367110:NCU00077
gene id: 367110:NCU00077
uniprot id: Q7RX73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ku80 family.
messages: Heterodimer of mus-51/ku70 and mus-52/ku80.
messages: Nucleus
messages: Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching (By similarity).
messages: telomere

367110:NCU09805
gene id: 367110:NCU09805
uniprot id: Q7SDJ6
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

367110:NCU05038
gene id: 367110:NCU05038
uniprot id: Q7RX50
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

367110:NCU05893
gene id: 367110:NCU05893
uniprot id: Q7S515
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU10166
gene id: 367110:NCU10166
uniprot id: Q871A4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

367110:NCU06530
gene id: 367110:NCU06530
uniprot id: Q7S897
names: Similarity
messages: Belongs to the palmitoyl-protein thioesterase family.

367110:NCU01996
gene id: 367110:NCU01996
uniprot id: Q7SFN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the palI/RIM9 family.
messages: Cell membrane
messages: Required for the proteolytic cleavage of the transcription factor pacc-1 in response to alkaline ambient pH.

367110:NCU09903
gene id: 367110:NCU09903
uniprot id: Q7S0E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.
messages: Cytoplasm

367110:NCU08382
gene id: 367110:NCU08382
uniprot id: Q7SD69
names: Subcellular Location Annotation
messages: Membrane

367110:NCU00501
gene id: 367110:NCU00501
uniprot id: Q7SE72
names: Similarity
messages: Belongs to the CBF/MAK21 family.

367110:NCU01480
gene id: 367110:NCU01480
uniprot id: Q7RXV2
names: Subcellular Location Annotation
messages: Membrane

367110:NCU01303
gene id: 367110:NCU01303
uniprot id: Q1K7W2
names: Similarity
messages: Belongs to the SCC4/mau-2 family.

367110:NCU07757
gene id: 367110:NCU07757
uniprot id: Q7S1S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

367110:NCU07567
gene id: 367110:NCU07567
uniprot id: Q7S1Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

367110:NCU02273
gene id: 367110:NCU02273
uniprot id: Q01294
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Vacuole

367110:NCU01792
gene id: 367110:NCU01792
uniprot id: F5HII2
names: Similarity
messages: Belongs to the p23/wos2 family.

367110:NCU07918
gene id: 367110:NCU07918
uniprot id: Q7SA00
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03010
gene id: 367110:NCU03010
uniprot id: Q1K933
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.

367110:NCU04348
gene id: 367110:NCU04348
uniprot id: Q7RX28
names: Subcellular Location Annotation
messages: nucleolus

367110:NCU02096
gene id: 367110:NCU02096
uniprot id: Q7SDB4
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

367110:NCU00784
gene id: 367110:NCU00784
uniprot id: Q7SFU6
names: Similarity
messages: Belongs to the FMO family.

367110:NCU02618
gene id: 367110:NCU02618
uniprot id: Q7SG02
names: Similarity
messages: Belongs to the peroxin-13 family.

367110:NCU07760
gene id: 367110:NCU07760
uniprot id: Q7S111
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 61 family.
messages: Secreted

367110:NCU03268
gene id: 367110:NCU03268
uniprot id: Q7SEG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

367110:NCU06661
gene id: 367110:NCU06661
uniprot id: Q1K6Z3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

367110:NCU06664
gene id: 367110:NCU06664
uniprot id: Q1K6Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the translin family.
messages: Nucleus

367110:NCU08408
gene id: 367110:NCU08408
uniprot id: Q7SC45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the battenin family.
messages: Involved in vacuolar transport and vacuole pH homeostasis. Also required for cytokinesis (By similarity).
messages: Vacuole membrane

367110:NCU00422
gene id: 367110:NCU00422
uniprot id: U9W548
names: Similarity
messages: Belongs to the peptidase M24 family.

367110:NCU12151
gene id: 367110:NCU12151
uniprot id: V5IMC9
names: Subcellular Location Annotation
messages: Membrane

367110:NCU00981
gene id: 367110:NCU00981
uniprot id: Q7SGE1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
messages: Component of the pre-66S ribosomal particle. Interacts with nop7 and rrp1. Interacts with rsa4 (via WD repeats).
messages: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity).
messages: nucleolus

367110:NCU01502
gene id: 367110:NCU01502
uniprot id: Q1K5K9
names: Subcellular Location Annotation
messages: nucleolus

367110:NCU09912
gene id: 367110:NCU09912
uniprot id: Q7S144
names: Subcellular Location Annotation
messages: Membrane

367110:NCU00493
gene id: 367110:NCU00493
uniprot id: Q7RWT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

367110:NCU09779
gene id: 367110:NCU09779
uniprot id: Q7S5T3
names: Cofactor
messages: Binds 1 Fe(2+) ion per subunit.

367110:NCU02599
gene id: 367110:NCU02599
uniprot id: Q7SG21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

367110:NCU06720
gene id: 367110:NCU06720
uniprot id: Q1K6X1
names: Similarity
messages: Belongs to the peptidase S10 family.

367110:NCU04275
gene id: 367110:NCU04275
uniprot id: Q9HGI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAD52 family.
messages: Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the mei-3/rad51 recombinase (By similarity).
messages: Nucleus
messages: Part of a complex that includes mei-3/rad51 and mus-11/rad52.

367110:NCU06721
gene id: 367110:NCU06721
uniprot id: Q1K6X0
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

367110:NCU06024
gene id: 367110:NCU06024
uniprot id: P07046
names: Activity Regulation
names: Function
names: Induction
names: Similarity
names: Subunit
messages: 3-dehydroshikimate dehydratase; part of the qa gene cluster that mediates the catabolism of quinic acid (QA) and as such, allows the use of QA as a sole carbon source (PubMed:2525625, PubMed:6458044). Catalyzes the third reaction in the inducible quinic acid catabolic pathway by converting dehydroshikimate to protocatechuate (PubMed:149131). The qa cluster encodes 3 inducible enymes (qa-2, qa-3 and qa-4) catalyzing the first three reactions in the catabolism of quinic acid to protocatechuic acid (also known as 3,4-Dihydroxybenzoic acid) (Probable).
messages: Belongs to the bacterial two-domain DSD family.
messages: Divalent cations such as Mg(2+), but also MO(2+), Mn(2+), Ba(2+), and Co(2+) activate the enzyme, whereas monovalent cations as K(+), Na(+), and NH4(+) decrease its activity slightly.
messages: Expression is induced in the presence of quinic acid (PubMed:6458044). The quinic acid (qa) gene cluster is subject to two levels of gene control: a primary system which responds to the presence of quinic acid via the qa-1S repressor protein that blocks the qa-1F activator, and a secondary system which represses transcription of qa genes in the presence of a preferred carbon source such as glucose (PubMed:9279395, PubMed:6458044, PubMed:12477937, PubMed:17597928, PubMed:19236936).
messages: Monomer.

367110:NCU03021
gene id: 367110:NCU03021
uniprot id: Q7SGZ5
names: Function
names: Similarity
messages: Belongs to the arrestin family. PalF/RIM8 subfamily.
messages: Required for the proteolytic cleavage of the transcription factor pacc-1 in response to alkaline ambient pH.

367110:NCU16374
gene id: 367110:NCU16374
uniprot id: V5IQJ6
names: Similarity
messages: Belongs to the acylphosphatase family.

367110:NCU09025
gene id: 367110:NCU09025
uniprot id: Q7S2V0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.
messages: This protein may be expected to contain an N-terminal transit peptide but none has been predicted.

367110:NCU00971
gene id: 367110:NCU00971
uniprot id: Q7SGF1
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.

367110:NCU07182
gene id: 367110:NCU07182
uniprot id: Q1K5V9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

367110:NCU04339
gene id: 367110:NCU04339
uniprot id: Q7RX37
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

367110:NCU05200
gene id: 367110:NCU05200
uniprot id: Q7S9D2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Nuclear serine protease which mediates apoptosis.
messages: Nucleus

367110:NCU03986
gene id: 367110:NCU03986
uniprot id: Q7RXJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

367110:NCU03616
gene id: 367110:NCU03616
uniprot id: Q01387
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Cell membrane
messages: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

367110:NCU06183
gene id: 367110:NCU06183
uniprot id: Q7SBI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS18 family.
messages: Membrane

367110:NCU06786
gene id: 367110:NCU06786
uniprot id: Q1K8Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU03118
gene id: 367110:NCU03118
uniprot id: Q7SFX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AlaDH/PNT family.
messages: Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis.
messages: Monomer.

367110:NCU02751
gene id: 367110:NCU02751
uniprot id: Q7SCY3
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.

367110:NCU00440
gene id: 367110:NCU00440
uniprot id: F5HH30
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

367110:NCU04003
gene id: 367110:NCU04003
uniprot id: Q1K620
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

367110:NCU01368
gene id: 367110:NCU01368
uniprot id: Q9P6U7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).

367110:NCU05426
gene id: 367110:NCU05426
uniprot id: Q9P5P0
names: Function
names: Similarity
messages: Belongs to the WD repeat CIA1 family.
messages: Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.

367110:NCU08752
gene id: 367110:NCU08752
uniprot id: Q7RWP5
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

367110:NCU06946
gene id: 367110:NCU06946
uniprot id: Q7S0X8
names: Subcellular Location Annotation
messages: Membrane

367110:NCU10143
gene id: 367110:NCU10143
uniprot id: A7UWZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

367110:NCU10512
gene id: 367110:NCU10512
uniprot id: A7UWT2
names: Subcellular Location Annotation
messages: Membrane

367110:NCU02482
gene id: 367110:NCU02482
uniprot id: V5IQA3
names: Similarity
messages: Belongs to the citrate synthase family.

367110:NCU00919
gene id: 367110:NCU00919
uniprot id: Q7SFC8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
messages: Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
messages: Interacts with the U3 snoRNA and is associated with the 90S and 40S pre-ribosomes.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

367110:NCU03243
gene id: 367110:NCU03243
uniprot id: Q7SCM8
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

367110:NCU00305
gene id: 367110:NCU00305
uniprot id: Q7RZQ9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU02790
gene id: 367110:NCU02790
uniprot id: Q7SD72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the wax synthase family.
messages: Membrane

367110:NCU07536
gene id: 367110:NCU07536
uniprot id: Q7S312
names: Similarity
messages: Belongs to the peptidase M14 family.

367110:NCU07547
gene id: 367110:NCU07547
uniprot id: Q7S302
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

367110:NCU03776
gene id: 367110:NCU03776
uniprot id: F5HEB1
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06338
gene id: 367110:NCU06338
uniprot id: V5IM93
uniprot id: V5IMJ3
names: Similarity
messages: Belongs to the type II topoisomerase family.

367110:NCU07987
gene id: 367110:NCU07987
uniprot id: Q1K8G0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the trans-sulfuration enzymes family.
messages: Cytoplasm
messages: Involved in de novo synthesis of methionine.
messages: Nucleus

367110:NCU07826
gene id: 367110:NCU07826
uniprot id: Q7SBD8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS19 family.

367110:NCU00790
gene id: 367110:NCU00790
uniprot id: Q1K927
names: Subcellular Location Annotation
messages: Membrane

367110:NCU16018
gene id: 367110:NCU16018
uniprot id: P08774
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 1 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Mitochondrion inner membrane

367110:NCU02285
gene id: 367110:NCU02285
uniprot id: V5IKF9
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

367110:NCU02195
gene id: 367110:NCU02195
uniprot id: Q7S4C6
names: Subcellular Location Annotation
messages: Membrane

367110:NCU08026
gene id: 367110:NCU08026
uniprot id: Q7SAL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

367110:NCU08919
gene id: 367110:NCU08919
uniprot id: Q872I5
uniprot id: V5IMG6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Component of the INO80 chromatin-remodeling complex.
messages: Nucleus
messages: The DBINO region is involved in binding to DNA.

367110:NCU06649
gene id: 367110:NCU06649
uniprot id: Q7S7I2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup85 family.
messages: Component of the nuclear pore complex (NPC).
messages: Functions as a component of the nuclear pore complex (NPC).
messages: nuclear pore complex

367110:NCU11241
gene id: 367110:NCU11241
uniprot id: A7UW54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LCL3 family.
messages: Membrane
messages: Mitochondrion

367110:NCU03737
gene id: 367110:NCU03737
uniprot id: Q1K7X3
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

367110:NCU09463
gene id: 367110:NCU09463
uniprot id: P10857
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

367110:NCU02027
gene id: 367110:NCU02027
uniprot id: Q9HFJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.
messages: Cytoplasm
messages: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.
messages: Nucleus

367110:NCU09106
gene id: 367110:NCU09106
uniprot id: Q7S159
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU03784
gene id: 367110:NCU03784
uniprot id: Q1K799
names: Subcellular Location Annotation
messages: Membrane

367110:NCU02283
gene id: 367110:NCU02283
uniprot id: Q7RVS8
names: Similarity
messages: Belongs to the protein kinase superfamily.

367110:NCU02304
gene id: 367110:NCU02304
uniprot id: Q7S566
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU02687
gene id: 367110:NCU02687
uniprot id: Q7SH42
names: Similarity
messages: Belongs to the activator 1 small subunits family.

367110:NCU00264
gene id: 367110:NCU00264
uniprot id: Q7RZU9
names: Similarity
messages: Belongs to the BolA/IbaG family.

367110:NCU09445
gene id: 367110:NCU09445
uniprot id: Q7S1X0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate esterase 15 (CE15) family.
messages: Glucuronoyl esterase which may play a significant role in biomass degradation, as it is considered to disconnect hemicellulose from lignin through the hydrolysis of the ester bond between 4-O-methyl-D-glucuronic acid residues of glucuronoxylans and aromatic alcohols of lignin.
messages: Secreted

367110:NCU01444
gene id: 367110:NCU01444
uniprot id: Q1K4R5
names: Subcellular Location Annotation
messages: Cell membrane

367110:NCU06839
gene id: 367110:NCU06839
uniprot id: V5IPC4
names: Subcellular Location Annotation
messages: Membrane

367110:NCU08313
gene id: 367110:NCU08313
uniprot id: Q7SA75
names: Function
names: Similarity
messages: Belongs to the HTP reductase family.
messages: Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.

367110:NCU05204
gene id: 367110:NCU05204
uniprot id: V5IP38
names: Similarity
messages: Belongs to the cullin family.

367110:NCU06511
gene id: 367110:NCU06511
uniprot id: U9W2U0
names: Function
names: Subcellular Location Annotation
messages: RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.
messages: nucleolus

367110:NCU00356
gene id: 367110:NCU00356
uniprot id: Q7RZL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

367110:NCU04727
gene id: 367110:NCU04727
uniprot id: Q7S6H7
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.

367110:NCU03171
gene id: 367110:NCU03171
uniprot id: Q7SEW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

367110:NCU03527
gene id: 367110:NCU03527
uniprot id: Q1K5E2
names: Function
names: Similarity
messages: Belongs to the QNG1 protein family.
messages: Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.

367110:NCU03503
gene id: 367110:NCU03503
uniprot id: Q8X0H8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.

367110:NCU02133
gene id: 367110:NCU02133
uniprot id: P07509
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homodimer.

367110:NCU03238
gene id: 367110:NCU03238
uniprot id: V5IPX5
names: Subcellular Location Annotation
messages: Membrane

367110:NCU02829
gene id: 367110:NCU02829
uniprot id: Q7SCR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

367110:NCU03141
gene id: 367110:NCU03141
uniprot id: O42790
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysophospholipase family.
messages: Catalyzes the release of fatty acids from lysophospholipids.
messages: Secreted

367110:NCU01066
gene id: 367110:NCU01066
uniprot id: P23623
names: Induction
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.
messages: By addition of L-amino acids after nitrogen starvation, by starvation in phosphate buffer and by the addition of protein synthesis inhibitors, D-amino acids, or ATP.

367110:NCU06054
gene id: 367110:NCU06054
uniprot id: Q7S4Z6
uniprot id: V5ILG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phytoene/squalene synthase family.
messages: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.
messages: Catalyzes the condensation of 2 two farnesyl pyrophosphate moieties to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. Required for the biosynthesis of ergosterol (By similarity).
messages: Endoplasmic reticulum membrane

367110:NCU02110
gene id: 367110:NCU02110
uniprot id: Q7RW00
names: Subcellular Location Annotation
messages: Membrane

367110:NCU01224
gene id: 367110:NCU01224
uniprot id: F5HCG6
names: Similarity
messages: Belongs to the AAA ATPase family.

367110:NCU06451
gene id: 367110:NCU06451
uniprot id: Q7RYW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS27 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Mitochondrion

367110:NCU10498
gene id: 367110:NCU10498
uniprot id: A7UW39
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

367110:NCU00631
gene id: 367110:NCU00631
uniprot id: Q7SI21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

367110:NCU16402
gene id: 367110:NCU16402
uniprot id: V5IPQ3
uniprot id: V5IR59
names: Similarity
messages: Belongs to the Gfa family.

367110:NCU02184
gene id: 367110:NCU02184
uniprot id: V5IPZ1
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.

367110:NCU09572
gene id: 367110:NCU09572
uniprot id: Q7S4M8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

367110:NCU08135
gene id: 367110:NCU08135
uniprot id: Q7S4J6
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.
messages: Component of the post-replicative DNA mismatch repair system (MMR).

367110:NCU07027
gene id: 367110:NCU07027
uniprot id: Q7S9A9
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

367110:NCU07506
gene id: 367110:NCU07506
uniprot id: V5INQ1
uniprot id: V5INW5
names: Similarity
messages: Belongs to the FAH family.

367110:NCU03560
gene id: 367110:NCU03560
uniprot id: Q8WZW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (By similarity).
messages: Nucleus

367110:NCU03846
gene id: 367110:NCU03846
uniprot id: V5IKY9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

367110:NCU04090
gene id: 367110:NCU04090
uniprot id: Q7RWL9
names: Similarity
messages: Belongs to the patched family.

367110:NCU02749
gene id: 367110:NCU02749
uniprot id: Q7SGA1
names: Similarity
messages: Belongs to the PP2C family.

367110:NCU05716
gene id: 367110:NCU05716
uniprot id: Q7SB96
names: Function
messages: Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.

367110:NCU04674
gene id: 367110:NCU04674
uniprot id: F5HHN2
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.
messages: Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity.

367110:NCU05363
gene id: 367110:NCU05363
uniprot id: Q1K8L2
names: Similarity
messages: Belongs to the AAA ATPase family.

367110:NCU04539
gene id: 367110:NCU04539
uniprot id: Q7RWG9
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

367110:NCU16971
gene id: 367110:NCU16971
uniprot id: V5IMT2
names: Similarity
messages: Belongs to the SWI5/SAE3 family.

367110:NCU00720
gene id: 367110:NCU00720
uniprot id: Q7SES6
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

367110:NCU01045
gene id: 367110:NCU01045
uniprot id: P09646
names: Similarity
messages: Belongs to the ribonuclease N1/T1 family.

367110:NCU16844
gene id: 367110:NCU16844
uniprot id: V5IP95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR11/QCR10 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (cob), cytochrome c1 (cyt-1) and Rieske protein (fes-1), 2 core protein subunits pep and ucr-1, and 5 low-molecular weight protein subunits qcr6, qcr7, qcr8, qcr9 and probably NCU16844/qcr10 (Probable). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplexes SCI(1)III(2), SCIII(2)IV(1) and SCIII(2)IV(2) as well as higher order I(x)III(y)IV(z) megacomplexes) (PubMed:17873079, PubMed:19239619).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Mitochondrion inner membrane

367110:NCU00538
gene id: 367110:NCU00538
uniprot id: Q7SDK6
names: Similarity
messages: Belongs to the DNA polymerase type-B-like family.

367110:NCU01751
gene id: 367110:NCU01751
uniprot id: Q1K5R5
names: Subcellular Location Annotation
messages: Membrane

367110:NCU10029
gene id: 367110:NCU10029
uniprot id: Q7S0E9
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.

367110:NCU03147
gene id: 367110:NCU03147
uniprot id: Q7SDU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBP4 family.
messages: Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b (By similarity).
messages: Mitochondrion inner membrane

367110:NCU03899
gene id: 367110:NCU03899
uniprot id: Q96U60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex, which consists of kpr-1/ndc80, kpr-2/nuf2, kpr-3/spc24 and kpr-4/spc25.
messages: Nucleus
messages: kinetochore

367110:NCU03188
gene id: 367110:NCU03188
uniprot id: Q7SGY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
messages: Mitochondrion membrane

367110:NCU08409
gene id: 367110:NCU08409
uniprot id: P13228
names: Similarity
messages: In the C-terminal section; belongs to the TrpB family.
messages: In the N-terminal section; belongs to the TrpA family.

367110:NCU06176
gene id: 367110:NCU06176
uniprot id: U9W2U5
uniprot id: U9W838
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

367110:NCU01282
gene id: 367110:NCU01282
uniprot id: Q871Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A component of the endosomal sorting required for transport complex III (ESCRT-III).
messages: Belongs to the SNF7 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Also required for the proteolytic cleavage of the transcription factor pacc-1 in response to alkaline ambient pH (By similarity).

367110:NCU02157
gene id: 367110:NCU02157
uniprot id: Q7SEQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ4 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least coq-3, coq-4, coq-5, coq-6, coq-7 and coq-9.
messages: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.
messages: Mitochondrion inner membrane

367110:NCU05232
gene id: 367110:NCU05232
uniprot id: Q7S8H6
names: Function
names: Similarity
messages: Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
messages: Belongs to the adaptor complexes large subunit family.

367110:NCU07608
gene id: 367110:NCU07608
uniprot id: V5ILU5
uniprot id: V5IM49
names: Similarity
messages: Belongs to the ribose 5-phosphate isomerase family.

367110:NCU09228
gene id: 367110:NCU09228
uniprot id: Q7S394
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

367110:NCU08926
gene id: 367110:NCU08926
uniprot id: Q871L5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG2 family.
messages: Endoplasmic reticulum membrane
messages: Lipid transfer protein required for autophagosome completion and peroxisome degradation. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. Atg-2 binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, using basic residues in its N-terminal region (NR) and to the expanding edge of the IM through its C-terminal region. The latter binding is assisted by an atg-18-PtdIns3P interaction. Atg-2 then extracts phospholipids from the membrane source using its NR and transfers them to atg-9 to the IM through its predicted beta-sheet-rich structure for membrane expansion.
messages: Preautophagosomal structure membrane

367110:NCU07361
gene id: 367110:NCU07361
uniprot id: Q7S0P8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN4 family.
messages: Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity). The CSN complex is involved in the regulation of the circadian clock through its control of the stability of the SCF(FWD1) complex.
messages: Component of the COP9 signalosome (CSN) complex.
messages: Cytoplasm
messages: Nucleus

367110:NCU11357
gene id: 367110:NCU11357
uniprot id: A7UWZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PRP19 family.
messages: Homotetramer.
messages: Nucleus
messages: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.

367110:NCU07620
gene id: 367110:NCU07620
uniprot id: Q7SB34
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03139
gene id: 367110:NCU03139
uniprot id: P07685
names: Cofactor
names: Similarity
messages: Binds 1 zinc ion.
messages: In the C-terminal section; belongs to the histidinol dehydrogenase family.

367110:NCU11249
gene id: 367110:NCU11249
uniprot id: A7UW85
names: Similarity
messages: Belongs to the peptidase M28 family.

367110:NCU02352
gene id: 367110:NCU02352
uniprot id: Q7S4X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

367110:NCU04600
gene id: 367110:NCU04600
uniprot id: V5ILA6
uniprot id: V5INS2
names: Similarity
messages: Belongs to the PP2C family.

367110:NCU04623
gene id: 367110:NCU04623
uniprot id: Q1K640
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

367110:NCU01783
gene id: 367110:NCU01783
uniprot id: Q1K5P7
names: Similarity
messages: Belongs to the PIGH family.

367110:NCU09546
gene id: 367110:NCU09546
uniprot id: Q7S2B5
names: Function
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.
messages: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.

367110:NCU04424
gene id: 367110:NCU04424
uniprot id: Q7RZ50
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU11341
gene id: 367110:NCU11341
uniprot id: A7UWW7
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

367110:NCU00915
gene id: 367110:NCU00915
uniprot id: Q7SFD2
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.

367110:NCU02235
gene id: 367110:NCU02235
uniprot id: V5IMQ2
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

367110:NCU08983
gene id: 367110:NCU08983
uniprot id: Q7S2Y6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Binds 2 magnesium ions. Also active with manganese.
messages: Nucleus
messages: Polymerase that creates the 3'-poly(A) tail of mRNA's.

367110:NCU04277
gene id: 367110:NCU04277
uniprot id: Q1K791
names: Similarity
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.

367110:NCU16003
gene id: 367110:NCU16003
uniprot id: P00422
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 11 subunits. The complex is composed of a catalytic core of 3 subunits Cox1, Cox2 and Cox3, encoded in the mitochondrial DNA, and 8 supernumerary subunits Cox4, Cox5a/Cox5, Cox6, Cox7, Cox8, Cox7a/Cox9, Cox6b/Cox12 and Cox6a/Cox13, which are encoded in the nuclear genome (PubMed:31316820). The complex exists as a monomer or a dimer and forms respiratory supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in various different assemblies (supercomplexes I(1)IV(1), I(1)III(3)IV(2), III(2)IV(1) and III(2)IV(2) as well as larger supercomplexes of compositions like I(1)III(2)IV(5-6)) (PubMed:17873079).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of Cox2 and heme A of Cox1 to the active site in Cox1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

367110:NCU04312
gene id: 367110:NCU04312
uniprot id: Q7S7L4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
messages: Self-associates. Interacts with ro-11/nde1 and dynein.
messages: cytoskeleton
messages: spindle pole

367110:NCU09937
gene id: 367110:NCU09937
uniprot id: Q7RUC1
names: Similarity
messages: Belongs to the glycosyl hydrolase 76 family.

367110:NCU04021
gene id: 367110:NCU04021
uniprot id: Q7RZJ1
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06512
gene id: 367110:NCU06512
uniprot id: Q1K5P6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

367110:NCU12022
gene id: 367110:NCU12022
uniprot id: V5IKI6
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03718
gene id: 367110:NCU03718
uniprot id: Q9C2M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dolichyldiphosphatase family.
messages: Endoplasmic reticulum membrane

367110:NCU01589
gene id: 367110:NCU01589
uniprot id: Q1K566
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

367110:NCU01993
gene id: 367110:NCU01993
uniprot id: Q7SFN8
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

367110:NCU12046
gene id: 367110:NCU12046
uniprot id: V5IKT0
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.

367110:NCU01481
gene id: 367110:NCU01481
uniprot id: Q7RXV1
names: Similarity
messages: Belongs to the amino acid/polyamine transporter 2 family.

367110:NCU04780
gene id: 367110:NCU04780
uniprot id: Q7S629
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
messages: Cytoplasm
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.

367110:NCU11372
gene id: 367110:NCU11372
uniprot id: V5IME7
uniprot id: V5IQ17
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

367110:NCU02293
gene id: 367110:NCU02293
uniprot id: Q7S577
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B family.

367110:NCU03425
gene id: 367110:NCU03425
uniprot id: Q1K5C3
names: Similarity
messages: Belongs to the threonine synthase family.

367110:NCU03853
gene id: 367110:NCU03853
uniprot id: Q9P3X9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.
messages: Cytoplasm
messages: Interacts with CyPBP37.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

367110:NCU03482
gene id: 367110:NCU03482
uniprot id: Q8WZS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity).
messages: May form heterododecamers with hel-2/rvb2. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex (By similarity).
messages: Nucleus

367110:NCU02111
gene id: 367110:NCU02111
uniprot id: Q7SDM3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: The myosin motor domain displays actin-stimulated ATPase activity and generates a mechanochemical force.
messages: The tail domain participates in molecular interactions that specify the role of the motor domain (By similarity). It is composed of several tail homology (TH) domains, namely a putative phospholipid-binding myosin tail domain (also named TH1), an Ala- and Pro-rich domain (TH2), followed by an SH3 domain and a C-terminal acidic domain (TH3).
messages: Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex (By similarity).
messages: actin patch

367110:NCU06541
gene id: 367110:NCU06541
uniprot id: Q7S9I5
names: Similarity
messages: Belongs to the glycosyltransferase 15 family.

367110:NCU10436
gene id: 367110:NCU10436
uniprot id: A7UWV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 17 family.
messages: cell wall

367110:NCU00027
gene id: 367110:NCU00027
uniprot id: Q7RY78
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEN15 family.
messages: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body (By similarity).
messages: tRNA splicing endonuclease is a heterotetramer composed of tsp-2/sen2, tsp-1/sen15, tsp-4/sen34 and tsp-5/sen54. Interacts directly with tsp-4/sen34 (By similarity).

367110:NCU03018
gene id: 367110:NCU03018
uniprot id: Q7SGZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat UTP18 family.
messages: nucleolus

367110:NCU04401
gene id: 367110:NCU04401
uniprot id: Q7RZ72
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

367110:NCU09257
gene id: 367110:NCU09257
uniprot id: Q7SF53
names: Similarity
messages: Belongs to the OPA3 family.

367110:NCU03282
gene id: 367110:NCU03282
uniprot id: Q7SDX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 3-HAO family.
messages: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
messages: Cytoplasm

367110:NCU06533
gene id: 367110:NCU06533
uniprot id: Q7S894
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

367110:NCU07830
gene id: 367110:NCU07830
uniprot id: P19115
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uS11 is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
messages: Component of the small ribosomal subunit (SSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Cytoplasm

367110:NCU05984
gene id: 367110:NCU05984
uniprot id: Q7S212
names: Similarity
messages: Belongs to the FPG family.

367110:NCU02668
gene id: 367110:NCU02668
uniprot id: Q7SH61
names: Similarity
messages: Belongs to the SUN family.

367110:NCU01105
gene id: 367110:NCU01105
uniprot id: Q1K875
names: Similarity
messages: Belongs to the peptidase C48 family.

367110:NCU04720
gene id: 367110:NCU04720
uniprot id: P38681
names: Cofactor
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Binds 1 siroheme per subunit.
messages: By nitrate.
messages: Homodimer.

367110:NCU04414
gene id: 367110:NCU04414
uniprot id: Q7RZ60
names: Similarity
messages: Belongs to the AAA ATPase family.

367110:NCU06939
gene id: 367110:NCU06939
uniprot id: Q7S0H7
names: Similarity
messages: Belongs to the peptidase M67C family.

367110:NCU04173
gene id: 367110:NCU04173
uniprot id: P78711
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.
messages: cytoskeleton

367110:NCU03495
gene id: 367110:NCU03495
uniprot id: Q1K4P5
names: Similarity
messages: Belongs to the PP2C family.

367110:NCU07117
gene id: 367110:NCU07117
uniprot id: V5IKK3
names: Similarity
names: Subunit
messages: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.
messages: Homotetramer.

367110:NCU02544
gene id: 367110:NCU02544
uniprot id: Q7SHS0
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

367110:NCU06179
gene id: 367110:NCU06179
uniprot id: Q7SBJ1
names: Similarity
messages: Belongs to the protein kinase superfamily.

367110:NCU01954
gene id: 367110:NCU01954
uniprot id: Q7SDY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the CWC24 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

367110:NCU07954
gene id: 367110:NCU07954
uniprot id: Q7S931
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit J family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

367110:NCU06942
gene id: 367110:NCU06942
uniprot id: Q7S0H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Membrane

367110:NCU03738
gene id: 367110:NCU03738
uniprot id: Q9C2P2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Cytoplasm

367110:NCU01422
gene id: 367110:NCU01422
uniprot id: Q871W6
names: Function
names: Similarity
messages: Belongs to the MBF1 family.
messages: Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.

367110:NCU01022
gene id: 367110:NCU01022
uniprot id: Q9P749
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP25 family.
messages: Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.
messages: nucleolus

367110:NCU02230
gene id: 367110:NCU02230
uniprot id: O13396
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family.
messages: Heterodimer of msh2 and msh6.
messages: Involved in post-replicative DNA-mismatch repair. Binds to mismatch-containing DNA (By similarity).
messages: Nucleus

367110:NCU00209
gene id: 367110:NCU00209
uniprot id: Q7RXL7
names: Subcellular Location Annotation
messages: nuclear pore complex

367110:NCU02422
gene id: 367110:NCU02422
uniprot id: Q7S4D7
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG9 family.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Forms a homotrimer with a solvated central pore, which is connected laterally to the cytosol through the cavity within each protomer. Acts as a lipid scramblase that uses its central pore to function: the central pore opens laterally to accommodate lipid headgroups, thereby enabling lipid flipping and redistribution of lipids added to the outer leaflet of apg-7/atg9-containing vesicles, thereby enabling growth into autophagosomes.
messages: Golgi apparatus membrane
messages: Homotrimer; forms a homotrimer with a central pore that forms a path between the two membrane leaflets.
messages: Phospholipid scramblase involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through atg-2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. Required for mitophagy. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Different machineries are required for anterograde trafficking to the PAS during either the Cvt pathway or bulk autophagy and for retrograde trafficking.
messages: Phosphorylated by apg-1. Apg-1 phosphorylation is required for preautophagosome elongation.
messages: Preautophagosomal structure membrane

367110:NCU07338
gene id: 367110:NCU07338
uniprot id: Q7SA25
names: Similarity
messages: Belongs to the glycosyltransferase 32 family.

367110:NCU09240
gene id: 367110:NCU09240
uniprot id: V5IQR6
uniprot id: V5IRS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vezatin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus

367110:NCU01469
gene id: 367110:NCU01469
uniprot id: Q7RXW2
names: Similarity
messages: Belongs to the IF-3 family.

367110:NCU02716
gene id: 367110:NCU02716
uniprot id: Q7SGD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP31 family.
messages: Nucleus

367110:NCU03497
gene id: 367110:NCU03497
uniprot id: Q1K4N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

367110:NCU16791
gene id: 367110:NCU16791
uniprot id: V5IQ41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family. IMP2 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

367110:NCU00624
gene id: 367110:NCU00624
uniprot id: Q7SI28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

367110:NCU08022
gene id: 367110:NCU08022
uniprot id: Q7SAL9
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

367110:NCU03797
gene id: 367110:NCU03797
uniprot id: Q1K7H3
names: Similarity
messages: Belongs to the peptidase C19 family.

367110:NCU09978
gene id: 367110:NCU09978
uniprot id: Q7S0K8
names: Subcellular Location Annotation
messages: Membrane

367110:NCU07578
gene id: 367110:NCU07578
uniprot id: Q7S114
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

367110:NCU06986
gene id: 367110:NCU06986
uniprot id: V5INW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

367110:NCU02284
gene id: 367110:NCU02284
uniprot id: V5ILM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: Interacts with TAN1.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
messages: nucleolus

367110:NCU09261
gene id: 367110:NCU09261
uniprot id: Q7SF49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS4/SLD5 family.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

367110:NCU02193
gene id: 367110:NCU02193
uniprot id: P33287
uniprot id: V5IMQ6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.
messages: Binds 1 metal ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Cytoplasm
messages: Homomer.

367110:NCU16890
gene id: 367110:NCU16890
uniprot id: V5IP20
uniprot id: V5IPJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRN7/TAF1B family.
messages: nucleolus

367110:NCU01550
gene id: 367110:NCU01550
uniprot id: Q9HE76
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Mitochondrion intermembrane space
messages: Monomer.
messages: cytosol

367110:NCU01213
gene id: 367110:NCU01213
uniprot id: Q9Y783
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homotetramer.
messages: Mitochondrion matrix

367110:NCU11309
gene id: 367110:NCU11309
uniprot id: A7UWP7
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03097
gene id: 367110:NCU03097
uniprot id: Q7SCZ0
names: Subcellular Location Annotation
messages: Membrane

367110:NCU04149
gene id: 367110:NCU04149
uniprot id: Q1K7K9
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.

367110:NCU05387
gene id: 367110:NCU05387
uniprot id: Q1K8H5
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.

367110:NCU01421
gene id: 367110:NCU01421
uniprot id: Q1K6L9
names: Similarity
messages: Belongs to the Cdt1 family.

367110:NCU04457
gene id: 367110:NCU04457
uniprot id: Q7RYF0
names: Subcellular Location Annotation
messages: Membrane

367110:NCU04991
gene id: 367110:NCU04991
uniprot id: Q7RW19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

367110:NCU09309
gene id: 367110:NCU09309
uniprot id: Q7SD84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

367110:NCU05750
gene id: 367110:NCU05750
uniprot id: Q7S4S2
names: Similarity
messages: Belongs to the RNase H family.

367110:NCU07831
gene id: 367110:NCU07831
uniprot id: Q7SBD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit C family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

367110:NCU00979
gene id: 367110:NCU00979
uniprot id: Q7SGE3
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: P1 and P2 exist as dimers at the large ribosomal subunit.

367110:NCU09117
gene id: 367110:NCU09117
uniprot id: Q7S0F8
names: Similarity
messages: Belongs to the glycosyl hydrolase 16 family.

367110:NCU02200
gene id: 367110:NCU02200
uniprot id: Q7S4C1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFH5 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses.

367110:NCU01065
gene id: 367110:NCU01065
uniprot id: Q1K8A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

367110:NCU04569
gene id: 367110:NCU04569
uniprot id: V5INS7
names: Similarity
messages: Belongs to the oxoprolinase family.

367110:NCU09595
gene id: 367110:NCU09595
uniprot id: Q1K8H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU08216
gene id: 367110:NCU08216
uniprot id: Q7S3M7
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

367110:NCU01348
gene id: 367110:NCU01348
uniprot id: Q1K7T0
names: Similarity
messages: Belongs to the arginase family.

367110:NCU11109
gene id: 367110:NCU11109
uniprot id: A7UWQ4
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03357
gene id: 367110:NCU03357
uniprot id: V5IN07
uniprot id: V5IN98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm

367110:NCU11237
gene id: 367110:NCU11237
uniprot id: A7UW49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

367110:NCU05290
gene id: 367110:NCU05290
uniprot id: Q7RVF7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

367110:NCU02053
gene id: 367110:NCU02053
uniprot id: Q7SDE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-Y family.
messages: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
messages: Nucleus

367110:NCU08620
gene id: 367110:NCU08620
uniprot id: Q7SFJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS9 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Cytoplasm

367110:NCU07176
gene id: 367110:NCU07176
uniprot id: Q1K5W2
names: Similarity
messages: Belongs to the amidinotransferase family.

367110:NCU05269
gene id: 367110:NCU05269
uniprot id: O74225
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Binds hsp30 independent of temperature or substrate.
messages: By heat shock.
messages: Cytoplasm
messages: The N-terminus is blocked.

367110:NCU02044
gene id: 367110:NCU02044
uniprot id: Q7SF34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: Cytoplasm
messages: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
messages: Monomer.

367110:NCU09561
gene id: 367110:NCU09561
uniprot id: Q7S432
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS3/PSF3 family.
messages: Component of the GINS complex which is a heterotetramer of div-26/sld5, drc-1/psf1, drc-2/psf2 and drc-3/psf3.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

367110:NCU00706
gene id: 367110:NCU00706
uniprot id: Q7RVK8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

367110:NCU03651
gene id: 367110:NCU03651
uniprot id: V5IL35
names: Similarity
messages: Belongs to the malic enzymes family.

367110:NCU07709
gene id: 367110:NCU07709
uniprot id: Q7S9J7
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06854
gene id: 367110:NCU06854
uniprot id: Q873C7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity).
messages: May form heterododecamers with hel-1/rvb1. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex (By similarity).
messages: Nucleus

367110:NCU05980
gene id: 367110:NCU05980
uniprot id: Q7S216
names: Similarity
messages: Belongs to the peptidase S10 family.

367110:NCU03040
gene id: 367110:NCU03040
uniprot id: Q7SDG8
names: Similarity
messages: Belongs to the type-1 OGG1 family.

367110:NCU04172
gene id: 367110:NCU04172
uniprot id: Q9C239
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FES1 family.
messages: Cytoplasm
messages: Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins (By similarity).

367110:NCU08669
gene id: 367110:NCU08669
uniprot id: Q7S8W6
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

367110:NCU07378
gene id: 367110:NCU07378
uniprot id: Q7S2I4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

367110:NCU00761
gene id: 367110:NCU00761
uniprot id: V5IQ24
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

367110:NCU03290
gene id: 367110:NCU03290
uniprot id: V5IQR9
uniprot id: V5IRL7
names: Similarity
messages: Belongs to the peptidase S9C family.

367110:NCU00643
gene id: 367110:NCU00643
uniprot id: Q7SI09
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the NAD-dependent oxidation of L-arabinitol to L-xylulose in the fungal L-arabinose catabolic pathway. L-arabinose catabolism is important for using plant material as a carbon source. Not active on D-arabinitol, D-sorbitol and D-mannitol.
messages: Homotetramer.

367110:NCU06226
gene id: 367110:NCU06226
uniprot id: Q7SBS9
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

367110:NCU06652
gene id: 367110:NCU06652
uniprot id: Q1K6M8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

367110:NCU07140
gene id: 367110:NCU07140
uniprot id: Q7S6B2
names: Subcellular Location Annotation
messages: Membrane

367110:NCU02563
gene id: 367110:NCU02563
uniprot id: Q7SHQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.
messages: Nucleus

367110:NCU06666
gene id: 367110:NCU06666
uniprot id: Q1K6Y9
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

367110:NCU04131
gene id: 367110:NCU04131
uniprot id: Q1K7M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-I/CTF3 family.
messages: Nucleus
messages: centromere

367110:NCU12069
gene id: 367110:NCU12069
uniprot id: V5IKK5
names: Similarity
messages: Belongs to the adenylate kinase family.

367110:NCU07773
gene id: 367110:NCU07773
uniprot id: Q1K688
names: Similarity
messages: Belongs to the thymidylate kinase family.

367110:NCU04903
gene id: 367110:NCU04903
uniprot id: Q7S1D2
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 Ca(2+) ion per subunit.
messages: extracellular space

367110:NCU06099
gene id: 367110:NCU06099
uniprot id: Q7S5I8
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

367110:NCU04508
gene id: 367110:NCU04508
uniprot id: Q7RY55
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

367110:NCU09027
gene id: 367110:NCU09027
uniprot id: Q7S2U8
names: Subcellular Location Annotation
messages: Membrane

367110:NCU00206
gene id: 367110:NCU00206
uniprot id: Q7RXM0
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

367110:NCU16009
gene id: 367110:NCU16009
uniprot id: Q35134
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Encoded from partially processed ndh-4L mRNA that terminates with the in-frame coding sequence of the first intron.
messages: In the C-terminal section; belongs to the LAGLIDADG endonuclease family.
messages: In the N-terminal section; belongs to the complex I subunit 4L family.
messages: Mitochondrial DNA endonuclease involved in intron homing.
messages: Mitochondrion membrane

367110:NCU08634
gene id: 367110:NCU08634
uniprot id: Q7SFI7
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU02795
gene id: 367110:NCU02795
uniprot id: Q7SEL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Nucleus

367110:NCU09024
gene id: 367110:NCU09024
uniprot id: Q7S2V1
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

367110:NCU04001
gene id: 367110:NCU04001
uniprot id: Q1K622
names: Function
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.
messages: Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.

367110:NCU08121
gene id: 367110:NCU08121
uniprot id: Q7SD05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: Nucleus

367110:NCU00419
gene id: 367110:NCU00419
uniprot id: Q7RYP4
names: Similarity
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.

367110:NCU04302
gene id: 367110:NCU04302
uniprot id: Q1K772
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

367110:NCU10809
gene id: 367110:NCU10809
uniprot id: A7UXF4
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU01007
gene id: 367110:NCU01007
uniprot id: Q1K8E0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Mitochondrion

367110:NCU11380
gene id: 367110:NCU11380
uniprot id: A7UX63
names: Similarity
messages: Belongs to the RUS1 family.

367110:NCU06051
gene id: 367110:NCU06051
uniprot id: Q7S4Z9
names: Similarity
messages: Belongs to the cytochrome b5 family.

367110:NCU02198
gene id: 367110:NCU02198
uniprot id: Q7S4C3
names: Similarity
messages: Belongs to the peptidase A1 family.

367110:NCU02051
gene id: 367110:NCU02051
uniprot id: Q7SF27
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06270
gene id: 367110:NCU06270
uniprot id: P23955
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Appears to contain two domains of approximately equal size which are separated by a loop-like sequence.
messages: Belongs to the peptidase M16 family.
messages: Heterodimer of mpp (alpha) and pep (beta) subunits, forming the mitochondrial processing protease (MPP) in which mpp is involved in substrate recognition and binding and pep is the catalytic subunit.
messages: Mitochondrion matrix
messages: Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.
messages: Was originally thought to be the catalytic subunit (PubMed:2967109). The low processing activity which was previously observed with alpha-MPP which has been immunoprecipitated from a mitochondrial extract is most likely due to contamination by the beta-subunit (PubMed:8106471). Does not seem to have protease activity as it lacks the zinc-binding site.

367110:NCU03221
gene id: 367110:NCU03221
uniprot id: Q7SGU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YPT35 family.
messages: Endosome membrane
messages: Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.
messages: Vacuole membrane

367110:NCU09250
gene id: 367110:NCU09250
uniprot id: Q7SF60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion inner membrane
messages: Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.

367110:NCU09887
gene id: 367110:NCU09887
uniprot id: Q7S227
names: Subcellular Location Annotation
messages: Membrane

367110:NCU01961
gene id: 367110:NCU01961
uniprot id: V5INX7
uniprot id: V5IQL8
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

367110:NCU07276
gene id: 367110:NCU07276
uniprot id: Q7S940
names: Subcellular Location Annotation
messages: Membrane

367110:NCU05901
gene id: 367110:NCU05901
uniprot id: Q7S404
names: Similarity
messages: Belongs to the APC1 family.

367110:NCU03982
gene id: 367110:NCU03982
uniprot id: P78695
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Endoplasmic reticulum lumen
messages: Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.
messages: The chaperone activity is regulated by ATP-induced allosteric coupling of the nucleotide-binding (NBD) and substrate-binding (SBD) domains. In the ADP-bound and nucleotide-free (apo) states, the two domains have little interaction. In contrast, in the ATP-bound state the two domains are tightly coupled, which results in drastically accelerated kinetics in both binding and release of polypeptide substrates. J domain-containing co-chaperones stimulate the ATPase activity and are required for efficient substrate recognition.

367110:NCU05430
gene id: 367110:NCU05430
uniprot id: P23704
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
messages: Mitochondrion
messages: Mitochondrion inner membrane

367110:NCU00667
gene id: 367110:NCU00667
uniprot id: Q9Y874
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1) (By similarity). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c'' (By similarity).
messages: Vacuole membrane

367110:NCU05287
gene id: 367110:NCU05287
uniprot id: Q7S910
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL29 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU11040
gene id: 367110:NCU11040
uniprot id: A7UWQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

367110:NCU03316
gene id: 367110:NCU03316
uniprot id: Q7SEM8
names: Function
names: Similarity
messages: Belongs to the palC family.
messages: Required for the proteolytic cleavage of the transcription factor pacc-1 in response to alkaline ambient pH.

367110:NCU07733
gene id: 367110:NCU07733
uniprot id: Q7S8Q8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF beta-subunit/FixA family.
messages: Binds 1 AMP per subunit.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

367110:NCU01512
gene id: 367110:NCU01512
uniprot id: Q1K5K3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Mitochondrion matrix

367110:NCU05767
gene id: 367110:NCU05767
uniprot id: Q7S4Q6
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU04490
gene id: 367110:NCU04490
uniprot id: Q7RYB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

367110:NCU09855
gene id: 367110:NCU09855
uniprot id: Q7S1B0
names: Similarity
messages: Belongs to the nicotianamine synthase (NAS)-like family.

367110:NCU00385
gene id: 367110:NCU00385
uniprot id: P56525
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
messages: Mitochondrion
messages: Mitochondrion inner membrane

367110:NCU00736
gene id: 367110:NCU00736
uniprot id: Q7SEE2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and MOCS2A. Its N-terminus first activates urm1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards urm1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; nfs1 probably acting as a sulfur donor for thiocarboxylation reactions.

367110:NCU07898
gene id: 367110:NCU07898
uniprot id: Q7SA19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 61 family.
messages: Secreted

367110:NCU04008
gene id: 367110:NCU04008
uniprot id: Q1K618
names: Similarity
messages: Belongs to the AFG1 ATPase family.

367110:NCU04819
gene id: 367110:NCU04819
uniprot id: Q7S6L6
names: Subcellular Location Annotation
messages: Membrane

367110:NCU11209
gene id: 367110:NCU11209
uniprot id: A7UVZ5
names: Function
names: Similarity
messages: Belongs to the VPS28 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.

367110:NCU07953
gene id: 367110:NCU07953
uniprot id: Q01355
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alternative oxidase family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.
messages: Homodimer; disulfide-linked.
messages: Mitochondrion inner membrane

367110:NCU16914
gene id: 367110:NCU16914
uniprot id: V5ILS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBT5 family.
messages: Membrane

367110:NCU03938
gene id: 367110:NCU03938
uniprot id: Q7RUA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERT1/acuK family.
messages: Nucleus
messages: Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes (By similarity).

367110:NCU01738
gene id: 367110:NCU01738
uniprot id: Q06712
names: Function
names: Similarity
messages: Belongs to the cyclin family.
messages: Negative regulator, together with pgov, of the transcriptional activator nuc-1, which controls the expression of phosphorous acquisition enzymes.

367110:NCU00467
gene id: 367110:NCU00467
uniprot id: Q7RXX8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M67A family. CSN5 subfamily.
messages: Catalytic component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes (By similarity). The CSN complex is involved in the regulation of the circadian clock through its control of the stability of the SCF(FWD-1) complex.
messages: Component of the COP9 signalosome (CSN) complex.
messages: Cytoplasm
messages: Nucleus
messages: The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins. It constitutes the catalytic center of the complex (By similarity).

367110:NCU06031
gene id: 367110:NCU06031
uniprot id: Q7S4F4
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

367110:NCU05225
gene id: 367110:NCU05225
uniprot id: Q7RVX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADH dehydrogenase family.
messages: Mitochondrion inner membrane

367110:NCU08148
gene id: 367110:NCU08148
uniprot id: Q7S4A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

367110:NCU07549
gene id: 367110:NCU07549
uniprot id: Q7S300
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL43 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU05638
gene id: 367110:NCU05638
uniprot id: Q7S622
names: Subcellular Location Annotation
messages: Membrane
messages: Preautophagosomal structure membrane

367110:NCU09262
gene id: 367110:NCU09262
uniprot id: Q7SF48
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU00159
gene id: 367110:NCU00159
uniprot id: Q7RXP9
names: Similarity
messages: Belongs to the SAP18 family.

367110:NCU07853
gene id: 367110:NCU07853
uniprot id: Q7SBV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uricase family.
messages: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
messages: Peroxisome

367110:NCU11187
gene id: 367110:NCU11187
uniprot id: A7UVV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU08715
gene id: 367110:NCU08715
uniprot id: F5HB83
names: Subcellular Location Annotation
messages: Membrane

367110:NCU09816
gene id: 367110:NCU09816
uniprot id: P07142
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme c group covalently per subunit.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (cob), cytochrome c1 (cyt-1) and Rieske protein (fes-1), 2 core protein subunits pep and ucr-1, and 5 low-molecular weight protein subunits qcr6, qcr7, qcr8, qcr9 and probably NCU16844/qcr10 (PubMed:226365, PubMed:6273583, PubMed:18251112, PubMed:6302289). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplexes SCI(1)III(2), SCIII(2)IV(1) and SCIII(2)IV(2) as well as higher order I(x)III(y)IV(z) megacomplexes) (PubMed:17873079, PubMed:19239619).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (PubMed:3015618) (Probable). Cytochrome c1 is a catalytic core subunit containing a c-type heme. It transfers electrons from the [2Fe-2S] iron-sulfur cluster of the Rieske protein to cytochrome c (By similarity).
messages: Mitochondrion inner membrane

367110:NCU02177
gene id: 367110:NCU02177
uniprot id: Q7SE06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM11 family.
messages: Membrane

367110:NCU00487
gene id: 367110:NCU00487
uniprot id: Q7RWU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.

367110:NCU02287
gene id: 367110:NCU02287
uniprot id: Q7S582
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

367110:NCU16002
gene id: 367110:NCU16002
uniprot id: Q35138
names: Subcellular Location Annotation
messages: Mitochondrion membrane

367110:NCU11426
gene id: 367110:NCU11426
uniprot id: Q01317
names: Function
messages: Controls phosphorus acquisition.

367110:NCU01494
gene id: 367110:NCU01494
uniprot id: Q1K4Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU08012
gene id: 367110:NCU08012
uniprot id: Q6MFS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EXO70 family.
messages: Bud
messages: Bud neck
messages: Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst (By similarity).

367110:NCU00301
gene id: 367110:NCU00301
uniprot id: Q7RZR3
names: Similarity
messages: Belongs to the SAS10 family.

367110:NCU07621
gene id: 367110:NCU07621
uniprot id: Q7SB33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

367110:NCU02973
gene id: 367110:NCU02973
uniprot id: Q96U08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.
messages: Mitochondrion inner membrane

367110:NCU06788
gene id: 367110:NCU06788
uniprot id: F5HH33
names: Similarity
names: Subunit
messages: Belongs to the MRG family.
messages: Component of the NuA4 histone acetyltransferase complex.

367110:NCU06560
gene id: 367110:NCU06560
uniprot id: Q7S9H5
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU08070
gene id: 367110:NCU08070
uniprot id: Q7SGL3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Cytoplasm
messages: Mitochondrion

367110:NCU00656
gene id: 367110:NCU00656
uniprot id: Q7SHZ6
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

367110:NCU03759
gene id: 367110:NCU03759
uniprot id: Q9C2H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Mitochondrion matrix

367110:NCU00810
gene id: 367110:NCU00810
uniprot id: Q7SEC4
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

367110:NCU04027
gene id: 367110:NCU04027
uniprot id: Q7RZI8
names: Similarity
messages: Belongs to the glycosyl hydrolase 7 (cellulase C) family.

367110:NCU02105
gene id: 367110:NCU02105
uniprot id: Q7SDM8
names: Cofactor
names: Function
names: Similarity
messages: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
messages: Belongs to the tRNA(His) guanylyltransferase family.
messages: Binds 2 magnesium ions per subunit.

367110:NCU03393
gene id: 367110:NCU03393
uniprot id: Q01291
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uS2 is required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.
messages: Component of the small ribosomal subunit (SSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins. Interacts with rps21.
messages: Cytoplasm

367110:NCU05519
gene id: 367110:NCU05519
uniprot id: Q7S6S0
names: Subcellular Location Annotation
messages: Membrane

367110:NCU08873
gene id: 367110:NCU08873
uniprot id: Q1K6K7
names: Similarity
messages: Belongs to the APC13 family.

367110:NCU01378
gene id: 367110:NCU01378
uniprot id: Q1K704
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

367110:NCU00097
gene id: 367110:NCU00097
uniprot id: Q7RYN1
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU00780
gene id: 367110:NCU00780
uniprot id: Q7SFV0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

367110:NCU08685
gene id: 367110:NCU08685
uniprot id: Q7S8V0
names: Similarity
messages: In the N-terminal section; belongs to the FGAMS family.

367110:NCU03169
gene id: 367110:NCU03169
uniprot id: Q7SEW3
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU16303
gene id: 367110:NCU16303
uniprot id: V5IQD8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

367110:NCU04936
gene id: 367110:NCU04936
uniprot id: V5IN23
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

367110:NCU01822
gene id: 367110:NCU01822
uniprot id: Q7RWC0
names: Similarity
messages: Belongs to the VPS29 family.

367110:NCU09545
gene id: 367110:NCU09545
uniprot id: Q7S2B6
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

367110:NCU00415
gene id: 367110:NCU00415
uniprot id: Q7RYP7
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in nonsense-mediated mRNA decay.

367110:NCU07719
gene id: 367110:NCU07719
uniprot id: Q7S8S0
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.

367110:NCU04786
gene id: 367110:NCU04786
uniprot id: Q7S6P9
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU11219
gene id: 367110:NCU11219
uniprot id: A7UW17
names: Similarity
messages: Belongs to the Nth/MutY family.

367110:NCU09754
gene id: 367110:NCU09754
uniprot id: Q7S0W3
names: Similarity
messages: Belongs to the frataxin family.

367110:NCU09543
gene id: 367110:NCU09543
uniprot id: Q7S2B8
names: Subcellular Location Annotation
messages: Membrane

367110:NCU08998
gene id: 367110:NCU08998
uniprot id: U9W589
uniprot id: U9W8R9
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

367110:NCU02170
gene id: 367110:NCU02170
uniprot id: Q7SEP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBT5 family.
messages: Membrane

367110:NCU00962
gene id: 367110:NCU00962
uniprot id: Q7SGG0
uniprot id: V5IR98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 12 family.
messages: Component of the SRB8-11 complex, which itself associates with the Mediator complex.
messages: Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.
messages: Component of the srb8-11 complex, which itself associates with the Mediator complex.
messages: Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity).
messages: Nucleus

367110:NCU02548
gene id: 367110:NCU02548
uniprot id: Q7SHR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS38 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Mitochondrion

367110:NCU08803
gene id: 367110:NCU08803
uniprot id: Q7S8T1
names: Similarity
messages: Belongs to the amidase family.

367110:NCU08741
gene id: 367110:NCU08741
uniprot id: Q7SCF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

367110:NCU00953
gene id: 367110:NCU00953
uniprot id: Q7SGG9
names: Subcellular Location Annotation
messages: Membrane

367110:NCU01779
gene id: 367110:NCU01779
uniprot id: Q1K5Q0
names: Similarity
messages: Belongs to the NifU family.

367110:NCU09538
gene id: 367110:NCU09538
uniprot id: Q7S2C3
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.

367110:NCU08340
gene id: 367110:NCU08340
uniprot id: Q7RVM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

367110:NCU00306
gene id: 367110:NCU00306
uniprot id: Q7RZQ8
names: Subcellular Location Annotation
messages: Membrane

367110:NCU07430
gene id: 367110:NCU07430
uniprot id: Q7SF22
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU11424
gene id: 367110:NCU11424
uniprot id: A7UXI1
names: Cofactor
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Impairs the production of neurosporaxanthin and leads to the accumulation of torulene.
messages: The expression is subject to photoinduction in a wc-1 and wc-2 dependent manner.
messages: Torulene dioxygenase; part of pathway that mediates the biosynthesis of neurosporaxanthin, a carboxylic apocarotenoid acting as an essential protective pigments and leading to orange pigmentation (PubMed:17610084). Cao-2 mediates the cleavage of torulene into beta-apo-4'-carotenal, the aldehyde corresponding to the acidic neurosporaxanthin (PubMed:17610084). Is not able to use gamma-carotene (that it is not desaturated at the C4'-C5' bond) as substrate, which suggests a high specificity of cao-2 in cleaving the C4'-C5' double bond (PubMed:17610084). Neurosporaxanthin is synthesized from geranyl-geranyl pyrophosphate (GGPP) through several enzymatic activities. Phytoene synthase activity performed by the bifunctional enzyme al-2 first produces phytoene from geranyl-geranyl pyrophosphate (GGPP). The phytoene dehydrogenase al-1 then introduces 5 desaturations to lead to 3,4-didehydrolycopene via the intermediates phytofluene, zeta-carotene, neurosporene and lycopene. Al-2 cyclase activity then converts 3,4-didehydrolycopene into torulene. Al-2 can also convet lycopene into gamma-carotene which in turn is converted to beta-carotene by an additional al-2 cyclization reaction. Torulene is the substrate of the dioxidase cao-2 that breaks the molecule, removing five carbon atoms to yield beta-apo-4'-carotenal, whereas the aldehyde dehydrogenase ylo-1 mediates the last step by converting beta-apo-4'-carotenal into neurosporaxanthin (Probable).
messages: cytosol

367110:NCU05889
gene id: 367110:NCU05889
uniprot id: Q7S519
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit E family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

367110:NCU07556
gene id: 367110:NCU07556
uniprot id: U9W3M5
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU05207
gene id: 367110:NCU05207
uniprot id: Q7S9C6
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06341
gene id: 367110:NCU06341
uniprot id: V5INH0
uniprot id: V5IQ61
names: Subcellular Location Annotation
messages: Membrane

367110:NCU11306
gene id: 367110:NCU11306
uniprot id: A7UWN9
names: Similarity
messages: Belongs to the cytochrome P450 family.

367110:NCU01115
gene id: 367110:NCU01115
uniprot id: Q9P6Y2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. This subunit may anchor the endonuclease complex to the nuclear membrane. Probably carries the active site for 5'-splice site cleavage (By similarity).
messages: tRNA splicing endonuclease is a heterotetramer composed of tsp-2/sen2, tsp-1/sen15, tsp-4/sen34 and tsp-5/sen54. Interacts directly with tsp-5/sen54 (By similarity).

367110:NCU02269
gene id: 367110:NCU02269
uniprot id: Q7S597
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

367110:NCU00782
gene id: 367110:NCU00782
uniprot id: Q7SFU8
names: Subcellular Location Annotation
messages: Membrane

367110:NCU09615
gene id: 367110:NCU09615
uniprot id: Q7RV27
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU00847
gene id: 367110:NCU00847
uniprot id: Q7SD92
names: Similarity
messages: Belongs to the asaB hydroxylase/desaturase family.

367110:NCU07941
gene id: 367110:NCU07941
uniprot id: Q7S9X7
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

367110:NCU01548
gene id: 367110:NCU01548
uniprot id: Q8WZY3
names: Similarity
messages: Belongs to the protease inhibitor I9 family.

367110:NCU02839
gene id: 367110:NCU02839
uniprot id: Q7RV38
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

367110:NCU02000
gene id: 367110:NCU02000
uniprot id: Q7SFN1
names: Similarity
messages: Belongs to the SF3B5 family.

367110:NCU01713
gene id: 367110:NCU01713
uniprot id: Q1K4U0
names: Similarity
messages: Belongs to the TBCB family.

367110:NCU02707
gene id: 367110:NCU02707
uniprot id: Q7SH22
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

367110:NCU06856
gene id: 367110:NCU06856
uniprot id: Q1K8J9
names: Similarity
messages: Belongs to the UFD1 family.

367110:NCU07938
gene id: 367110:NCU07938
uniprot id: Q7S9Y0
names: Subcellular Location Annotation
messages: Membrane

367110:NCU05561
gene id: 367110:NCU05561
uniprot id: P02807
names: Induction
names: Miscellaneous
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 8 family.
messages: By copper.
messages: The seven cysteines bind six copper (cuprous) ions.

367110:NCU07417
gene id: 367110:NCU07417
uniprot id: Q7S1F6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Golgi apparatus membrane
messages: Golgi membrane protein involved in vesicular trafficking and spindle migration.

367110:NCU00548
gene id: 367110:NCU00548
uniprot id: Q7SFA0
names: Similarity
messages: Belongs to the Nudix hydrolase family.

367110:NCU04504
gene id: 367110:NCU04504
uniprot id: Q7RY59
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.
messages: Nucleus
messages: Required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA (By similarity).
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

367110:NCU04455
gene id: 367110:NCU04455
uniprot id: Q7RWB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAF1 family.
messages: Nucleus

367110:NCU04114
gene id: 367110:NCU04114
uniprot id: Q7S7U5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIa family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 11 subunits. The complex is composed of a catalytic core of 3 subunits Cox1, Cox2 and Cox3, encoded in the mitochondrial DNA, and 8 supernumerary subunits Cox4, Cox5a/Cox5, Cox6, Cox7, Cox8, Cox7a/Cox9, Cox6b/Cox12 and Cox6a/Cox13, which are encoded in the nuclear genome (PubMed:31316820). The complex exists as a monomer or a dimer and forms respiratory supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in various different assemblies (supercomplexes I(1)IV(1), I(1)III(3)IV(2), III(2)IV(1) and III(2)IV(2) as well as larger supercomplexes of compositions like I(1)III(2)IV(5-6)) (PubMed:17873079).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of Cox2 and heme A of Cox1 to the active site in Cox1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

367110:NCU02028
gene id: 367110:NCU02028
uniprot id: Q1K921
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

367110:NCU08167
gene id: 367110:NCU08167
uniprot id: Q7S4I3
names: Similarity
messages: Belongs to the lysine N-acyltransferase MbtK family.

367110:NCU16006
gene id: 367110:NCU16006
uniprot id: Q35140
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Mitochondrion inner membrane

367110:NCU00726
gene id: 367110:NCU00726
uniprot id: P10255
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family.
messages: Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.
messages: Cytoplasm
messages: Mitochondrion
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
messages: Produced by alternative initiation.
messages: Produced by alternative splicing. This isoform is found in the cell following 22 hours growth in dark.

367110:NCU05153
gene id: 367110:NCU05153
uniprot id: Q1K589
names: Function
messages: Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.

367110:NCU04439
gene id: 367110:NCU04439
uniprot id: Q7RZ35
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2 (By similarity).
messages: Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.
messages: Interacts with the U3 and U14 snoRNAs. Associates with pre-ribosomal complexes (By similarity).
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

367110:NCU05360
gene id: 367110:NCU05360
uniprot id: Q1K8L3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Membrane

367110:NCU03952
gene id: 367110:NCU03952
uniprot id: Q7RZB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: nucleolus

367110:NCU16385
gene id: 367110:NCU16385
uniprot id: V5IQY7
names: Similarity
messages: Belongs to the glutaredoxin family.

367110:NCU00120
gene id: 367110:NCU00120
uniprot id: Q7RYK9
names: Similarity
messages: Belongs to the NRDE2 family.

367110:NCU08199
gene id: 367110:NCU08199
uniprot id: Q7RV07
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

367110:NCU04948
gene id: 367110:NCU04948
uniprot id: Q7S3R9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBT5 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

367110:NCU08370
gene id: 367110:NCU08370
uniprot id: Q7SGP5
names: Similarity
messages: Belongs to the RMD1/sif2 family.

367110:NCU08314
gene id: 367110:NCU08314
uniprot id: Q7SA74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYSTM1 family.
messages: Membrane

367110:NCU08858
gene id: 367110:NCU08858
uniprot id: Q7S7L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU06144
gene id: 367110:NCU06144
uniprot id: Q7S5E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

367110:NCU05989
gene id: 367110:NCU05989
uniprot id: V5IM94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRH/QCR6 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (cob), cytochrome c1 (cyt-1) and Rieske protein (fes-1), 2 core protein subunits pep and ucr-1, and 5 low-molecular weight protein subunits qcr6, qcr7, qcr8, qcr9 and probably NCU16844/qcr10 (PubMed:226365, PubMed:6273583, PubMed:18251112, PubMed:6302289). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplexes SCI(1)III(2), SCIII(2)IV(1) and SCIII(2)IV(2) as well as higher order I(x)III(y)IV(z) megacomplexes) (PubMed:17873079, PubMed:19239619).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Mitochondrion inner membrane

367110:NCU07408
gene id: 367110:NCU07408
uniprot id: Q96TJ5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the large ribosomal subunit (LSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins (Probable). The acidic ribosomal P-proteins form the stalk structure of the 60S subunit. They are organized as a pentameric complex in which uL10/P0 interacts with 2 heterodimers of P1 and P2 proteins. uL10 directly interacts with 28S rRNA (By similarity).
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.
messages: Cytoplasm
messages: Phosphorylated.

367110:NCU06577
gene id: 367110:NCU06577
uniprot id: Q1K8E6
names: Similarity
messages: Belongs to the MAD2 family.

367110:NCU07092
gene id: 367110:NCU07092
uniprot id: Q7S683
names: Similarity
messages: Belongs to the cytochrome P450 family.

367110:NCU02226
gene id: 367110:NCU02226
uniprot id: Q7S4G7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
messages: Cytoplasm
messages: Nucleus

367110:NCU04636
gene id: 367110:NCU04636
uniprot id: Q1K6H7
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

367110:NCU06678
gene id: 367110:NCU06678
uniprot id: Q7S7J5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-3' exonuclease family.
messages: Cytoplasm
messages: Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.

367110:NCU00243
gene id: 367110:NCU00243
uniprot id: Q7RZW8
names: Similarity
messages: Belongs to the MAPRE family.

367110:NCU08365
gene id: 367110:NCU08365
uniprot id: Q7SGQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 8 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

367110:NCU01927
gene id: 367110:NCU01927
uniprot id: V5IQ63
uniprot id: V5IQM5
names: Subunit
messages: Component of the ESCRT-0 complex composed of HSE1 and VPS27.

367110:NCU08720
gene id: 367110:NCU08720
uniprot id: F5HEQ0
names: Subcellular Location Annotation
messages: Secreted

367110:NCU09357
gene id: 367110:NCU09357
uniprot id: Q7S2N1
names: Similarity
messages: Belongs to the CbxX/CfxQ family.

367110:NCU06868
gene id: 367110:NCU06868
uniprot id: Q7S0J9
names: Function
names: Subcellular Location Annotation
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane

367110:NCU03516
gene id: 367110:NCU03516
uniprot id: Q1K4P1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL32 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins. bL32m has a zinc binding site.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU09643
gene id: 367110:NCU09643
uniprot id: Q7S279
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

367110:NCU08480
gene id: 367110:NCU08480
uniprot id: Q7RV23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

367110:NCU06386
gene id: 367110:NCU06386
uniprot id: Q7S9G1
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

367110:NCU00589
gene id: 367110:NCU00589
uniprot id: Q7SI62
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06568
gene id: 367110:NCU06568
uniprot id: Q7S9H0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the NUF2 family.
messages: Component of the NDC80 complex, which consists of kpr-1/ndc80, kpr-2/nuf2, kpr-3/spc24 and kpr-4/spc25.
messages: Nucleus
messages: kinetochore

367110:NCU04405
gene id: 367110:NCU04405
uniprot id: Q7RZ69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mago nashi family.
messages: Nucleus

367110:NCU09795
gene id: 367110:NCU09795
uniprot id: Q7S5Z8
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03889
gene id: 367110:NCU03889
uniprot id: Q7RZD8
names: Subcellular Location Annotation
messages: Membrane

367110:NCU00936
gene id: 367110:NCU00936
uniprot id: V5IPY2
uniprot id: V5IQD0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

367110:NCU02459
gene id: 367110:NCU02459
uniprot id: Q7S447
names: Similarity
messages: Belongs to the MEMO1 family.

367110:NCU07392
gene id: 367110:NCU07392
uniprot id: Q9P326
names: Function
names: Subcellular Location Annotation
messages: May be involved in fruiting body development.
messages: Nucleus

367110:NCU06110
gene id: 367110:NCU06110
uniprot id: Q1K6I4
names: Cofactor
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THI4 family.
messages: Binds 1 Fe cation per subunit.
messages: Cytoplasm
messages: During the catalytic reaction, a sulfide is transferred from Cys-232 to a reaction intermediate, generating a dehydroalanine residue.
messages: Homooctamer (By similarity). Interacts with cyp-41.
messages: Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.
messages: Nucleus
messages: Repressed by thiamine, but not by thiazole. Induced by various stress conditions, including heat, cold or osmotic shock.

367110:NCU07944
gene id: 367110:NCU07944
uniprot id: Q7S9X4
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.

367110:NCU08771
gene id: 367110:NCU08771
uniprot id: F5HBC9
names: Similarity
messages: Belongs to the TPP enzyme family.

367110:NCU06724
gene id: 367110:NCU06724
uniprot id: Q86ZF9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Homooctamer.

367110:NCU02348
gene id: 367110:NCU02348
uniprot id: Q7RVS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

367110:NCU07029
gene id: 367110:NCU07029
uniprot id: Q7S9A7
names: Similarity
messages: Belongs to the RNase T2 family.
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

367110:NCU08776
gene id: 367110:NCU08776
uniprot id: Q7RWN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

367110:NCU07779
gene id: 367110:NCU07779
uniprot id: Q9C2R2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity). Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA (By similarity).
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

367110:NCU06432
gene id: 367110:NCU06432
uniprot id: Q7RV74
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

367110:NCU00715
gene id: 367110:NCU00715
uniprot id: Q7SET1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

367110:NCU04395
gene id: 367110:NCU04395
uniprot id: Q7M4T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 30 family.
messages: Partially degrades N.crassa cell wall beta-D-glucan, liberating small amounts of oligosaccharides.
messages: Secreted

367110:NCU09300
gene id: 367110:NCU09300
uniprot id: V5IL65
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: This promotes the activity of RNA polymerase II.

367110:NCU07008
gene id: 367110:NCU07008
uniprot id: Q7S860
names: Cofactor
names: Function
names: Induction
names: Similarity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Dioxygenase that cleaves the interphenyl C-alpha-C-beta double bond of resveratrol to yield 3,5-dihydroxybenzaldehyde and 4-hydroxybenzaldehyde (PubMed:23893079, PubMed:28493664). Cleaves also piceatannol, a compound that differs from resveratrol only in the occurrence of an additional hydroxyl group, which leads to the production of 3,4-dihydroxybenzaldehyde and 3,5-hydroxybenzaldehyde (PubMed:23893079, PubMed:28493664). Is not able to cleave trans-stilbene, 4-monohydroxy-trans-stilbene, 3,5-dihydroxy-trans-stilbene (pinosylvin), trismethoxy-resveratrol, and 3,3',5-trihydroxy-4'-methoxystilbene-3-O-beta-D-glucoside (PubMed:23893079). Is not involved in carotenoid metabolism (PubMed:23893079).
messages: Expression is induced ba resveratrol but is not dependent on light.

367110:NCU05599
gene id: 367110:NCU05599
uniprot id: Q7S6W5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS28 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Component of the small ribosomal subunit (SSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Cytoplasm

367110:NCU09685
gene id: 367110:NCU09685
uniprot id: Q1K6J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anthrone oxygenase family.
messages: Membrane

367110:NCU04099
gene id: 367110:NCU04099
uniprot id: Q1K6V5
names: Similarity
messages: Belongs to the CoA-transferase III family.

367110:NCU09862
gene id: 367110:NCU09862
uniprot id: Q7S5Z2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

367110:NCU16004
gene id: 367110:NCU16004
uniprot id: P0CY45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
messages: Mitochondrion membrane

367110:NCU02466
gene id: 367110:NCU02466
uniprot id: Q7SG97
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PROPPIN family.
messages: Cytoplasmic vesicle membrane
messages: Involved in mitochondrial or peroxisomal functions and amino acid signaling pathways.
messages: May contain a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane.
messages: Vacuole membrane

367110:NCU04156
gene id: 367110:NCU04156
uniprot id: Q92254
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG2 family.
messages: Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols.
messages: Endoplasmic reticulum membrane

367110:NCU05273
gene id: 367110:NCU05273
uniprot id: Q7S8L0
names: Similarity
messages: Belongs to the VPS52 family.

367110:NCU03757
gene id: 367110:NCU03757
uniprot id: Q1K7B7
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

367110:NCU00662
gene id: 367110:NCU00662
uniprot id: Q7SHZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: Nucleus
messages: Required for pre-mRNA splicing.

367110:NCU09735
gene id: 367110:NCU09735
uniprot id: Q7SEJ0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU01656
gene id: 367110:NCU01656
uniprot id: Q7RVP2
names: Similarity
messages: Belongs to the WD repeat LST8 family.

367110:NCU06777
gene id: 367110:NCU06777
uniprot id: Q1K8Z3
names: Similarity
messages: Belongs to the syntaxin family.

367110:NCU00717
gene id: 367110:NCU00717
uniprot id: Q7SES9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

367110:NCU07577
gene id: 367110:NCU07577
uniprot id: Q7S115
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOSIP family.
messages: Nucleus

367110:NCU07776
gene id: 367110:NCU07776
uniprot id: Q1K686
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBT5 family.
messages: Membrane

367110:NCU00211
gene id: 367110:NCU00211
uniprot id: U9W8F2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL60 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU08595
gene id: 367110:NCU08595
uniprot id: Q7SCN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPF2 family.
messages: nucleolus

367110:NCU16014
gene id: 367110:NCU16014
uniprot id: Q35127
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Mitochondrial DNA endonuclease involved in intron homing.
messages: Mitochondrion inner membrane
messages: The mature protein may arise from proteolytic cleavage of an in-frame translation of cob exon 1 plus intron 1, containing the bI1 open reading frame.
messages: To endonucleases of group I introns of fungi and phage.

367110:NCU07472
gene id: 367110:NCU07472
uniprot id: Q7SCP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU00891
gene id: 367110:NCU00891
uniprot id: Q7SFE0
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

367110:NCU09049
gene id: 367110:NCU09049
uniprot id: Q7S1V0
names: Subcellular Location Annotation
messages: Membrane

367110:NCU08656
gene id: 367110:NCU08656
uniprot id: Q7S8P7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular space

367110:NCU07607
gene id: 367110:NCU07607
uniprot id: Q7SB47
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

367110:NCU07736
gene id: 367110:NCU07736
uniprot id: Q7S0V6
names: Subcellular Location Annotation
messages: Membrane

367110:NCU04442
gene id: 367110:NCU04442
uniprot id: Q7RZ32
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

367110:NCU04192
gene id: 367110:NCU04192
uniprot id: Q1K7D9
names: Similarity
messages: Belongs to the peptidase M18 family.

367110:NCU02003
gene id: 367110:NCU02003
uniprot id: Q01372
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

367110:NCU05658
gene id: 367110:NCU05658
uniprot id: Q7SAU1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
messages: telomere

367110:NCU00065
gene id: 367110:NCU00065
uniprot id: Q7RX85
names: Function
names: Similarity
messages: Belongs to the Dus family. Dus3 subfamily.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs (By similarity). Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.

367110:NCU07587
gene id: 367110:NCU07587
uniprot id: Q7SBG9
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU05515
gene id: 367110:NCU05515
uniprot id: Q7S6S4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM16/PAM16 family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (hsp70-5) via its interaction with tim14/pam18. May act by positioning tim14/pam18 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation (By similarity).
messages: Heterodimer with tim14/pam18. Component of the PAM complex, at least composed of hsp70-5/ssc1, grpe/mge1, tim44, un-4/pam16, pam17 and tim14/pam18 (By similarity).
messages: Mitochondrion inner membrane
messages: The J-like region, although related to the J domain does not stimulate ATPase activity of mtHSP70. It nevertheless mediates the heterodimerization with the J domain of PAM18 and is therefore essential for PAM complex function (By similarity).

367110:NCU04430
gene id: 367110:NCU04430
uniprot id: Q7RZ44
names: Similarity
messages: Belongs to the peptidase M28 family. M28A subfamily.

367110:NCU04433
gene id: 367110:NCU04433
uniprot id: P23622
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Highly expressed, but only in cells subject to sulfur limitation, and it is turned on by the positive-acting 'Cys-3' sulfur regulatory protein.
messages: Mainly found in mycelia.
messages: Membrane
messages: Uptake of sulfate into the cell.

367110:NCU01254
gene id: 367110:NCU01254
uniprot id: Q7S725
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Endoplasmic reticulum membrane
messages: Functions as a zinc transporter.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

367110:NCU06167
gene id: 367110:NCU06167
uniprot id: Q7S5C1
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06272
gene id: 367110:NCU06272
uniprot id: Q7SB69
names: Subcellular Location Annotation
messages: nucleolus

367110:NCU11283
gene id: 367110:NCU11283
uniprot id: A7UWE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat ASA1 family.
messages: Component of the ASTRA chromatin remodeling machinery complex.
messages: Component of the ASTRA complex involved in chromatin remodeling.
messages: Nucleus

367110:NCU01225
gene id: 367110:NCU01225
uniprot id: Q1K827
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

367110:NCU16722
gene id: 367110:NCU16722
uniprot id: V5IM47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-L/IML3 family.
messages: Nucleus

367110:NCU06351
gene id: 367110:NCU06351
uniprot id: Q7S9V5
names: Similarity
messages: Belongs to the histidine acid phosphatase family.

367110:NCU00335
gene id: 367110:NCU00335
uniprot id: Q7RZM9
names: Function
names: Similarity
messages: Belongs to the CWC15 family.
messages: Involved in pre-mRNA splicing.

367110:NCU01318
gene id: 367110:NCU01318
uniprot id: Q9C284
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: The COPII coat is composed of at least 5 proteins: the sec23/24 complex, the sec13/31 complex, and the protein vtr-7/sar1.

367110:NCU07857
gene id: 367110:NCU07857
uniprot id: Q7RVY8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

367110:NCU09686
gene id: 367110:NCU09686
uniprot id: Q01306
names: Disruption Phenotype
names: Function
names: Induction
messages: Expression levels may be influenced by circadian rhythms.
messages: Leads to hypersensitivity to azoles (PubMed:24342650). Accumulates toxic sterol 14-alpha-methyl-3,6-diol and ketoconazole in the cells (PubMed:30603874).
messages: Transcription factor that plays a pivotal role in azole adaptive responses by regulating the drug accumulation in the cells (PubMed:24342650, PubMed:30603874). Affects the transcriptional responses to ketoconazole of many genes, including the target gene (erg11), an azole transporter gene (cdr4), a hexose transporter gene (hxt13), a stress response gene (kts-1), two transcription factor genes (named kts-2 and fsd-1/ndt80) (PubMed:24342650). Regulates also phospholipid synthesis that is not involved in azole resistance (PubMed:24342650).

367110:NCU00200
gene id: 367110:NCU00200
uniprot id: P00908
names: Function
names: Subunit
messages: Tetramer of two components I and two components II.
messages: Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.

367110:NCU05008
gene id: 367110:NCU05008
uniprot id: P11943
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group (By similarity).
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). May be involved in the synthesis of very-long-chain fatty acids. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (By similarity).
messages: Complex I is composed of about 30 different subunits.
messages: Mitochondrion

367110:NCU03253
gene id: 367110:NCU03253
uniprot id: Q7SEH4
names: Subcellular Location Annotation
messages: Membrane

367110:NCU09090
gene id: 367110:NCU09090
uniprot id: V5IRB7
names: Similarity
messages: Belongs to the PPC synthetase family.

367110:NCU03435
gene id: 367110:NCU03435
uniprot id: Q1K5B7
names: Similarity
messages: Belongs to the RENT3 family.

367110:NCU02264
gene id: 367110:NCU02264
uniprot id: V5IKN3
uniprot id: V5IMP3
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

367110:NCU00490
gene id: 367110:NCU00490
uniprot id: U9W574
names: Subcellular Location Annotation
messages: Membrane

367110:NCU00834
gene id: 367110:NCU00834
uniprot id: Q7SEA0
names: Subcellular Location Annotation
messages: Membrane

367110:NCU07367
gene id: 367110:NCU07367
uniprot id: Q7S2J5
names: Similarity
messages: Belongs to the AAA ATPase family.

367110:NCU09350
gene id: 367110:NCU09350
uniprot id: Q7S2N8
names: Similarity
messages: Belongs to the peptidase A1 family.

367110:NCU09677
gene id: 367110:NCU09677
uniprot id: Q7S7C8
names: Subcellular Location Annotation
messages: Membrane

367110:NCU08217
gene id: 367110:NCU08217
uniprot id: Q7S3M6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP receptor beta subunit family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU02513
gene id: 367110:NCU02513
uniprot id: Q7SHU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Cytoplasm

367110:NCU00340
gene id: 367110:NCU00340
uniprot id: Q1K623
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STE12 transcription factor family.
messages: Nucleus

367110:NCU07295
gene id: 367110:NCU07295
uniprot id: Q9C0Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM54 family.
messages: Component of the TIM22 complex, whose core is composed of tim22 and tim54, associated with the 70 kDa heterohexamer composed of tim9 and tim10 (or tim8 and tim13).
messages: Essential component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as external driving force (By similarity).
messages: Mitochondrion inner membrane

367110:NCU04945
gene id: 367110:NCU04945
uniprot id: Q7S3S2
names: Cofactor
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cu(2+) or Zn(2+).
messages: Mitochondrion inner membrane
messages: Monomer.
messages: Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (By similarity).
messages: The CHCH domain contains a conserved twin Cys-X(9)-Cys motif which is required for import and stability of MIA40 in mitochondria.

367110:NCU09367
gene id: 367110:NCU09367
uniprot id: Q7SCR6
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

367110:NCU02702
gene id: 367110:NCU02702
uniprot id: Q7SH27
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

367110:NCU05526
gene id: 367110:NCU05526
uniprot id: V5IKX8
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.

367110:NCU06059
gene id: 367110:NCU06059
uniprot id: Q7S4Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the translin family.
messages: Nucleus

367110:NCU09312
gene id: 367110:NCU09312
uniprot id: Q1K901
names: Similarity
messages: Belongs to the UPP synthase family.

367110:NCU06923
gene id: 367110:NCU06923
uniprot id: Q7S3D0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

367110:NCU03910
gene id: 367110:NCU03910
uniprot id: Q9P5L0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome b5 family.
messages: Endoplasmic reticulum membrane
messages: Membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.
messages: Microsome membrane

367110:NCU08195
gene id: 367110:NCU08195
uniprot id: Q7S3P2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

367110:NCU05230
gene id: 367110:NCU05230
uniprot id: Q7S8H8
names: Subcellular Location Annotation
messages: Membrane

367110:NCU10066
gene id: 367110:NCU10066
uniprot id: Q7S028
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

367110:NCU00430
gene id: 367110:NCU00430
uniprot id: Q7RXS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fungal Na(+)/H(+) exchanger family.
messages: Membrane

367110:NCU00145
gene id: 367110:NCU00145
uniprot id: Q7RXR3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H3 family.
messages: Component of centromeric nucleosomes, where DNA is wrapped around a histone octamer core. The octamer contains two molecules each of H2A, H2B, hH3v/CENPA and H4 assembled in one hH3v-H4 heterotetramer and two H2A-H2B heterodimers. Interacts with the inner kinetochore.
messages: Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity).
messages: Nucleus
messages: Ubiquitinated. Is degraded through ubiquitin-mediated proteolysis when not protected by its association to the kinetochore.
messages: centromere

367110:NCU01376
gene id: 367110:NCU01376
uniprot id: Q1K706
names: Cofactor
names: Similarity
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.

367110:NCU00902
gene id: 367110:NCU00902
uniprot id: P78714
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: By blue light.
messages: Heterodimer of wc-1 and wc-2 (Potential). Binds to DNA.
messages: May function as a transcription factor involved in light regulation. Binds and affects blue light regulation of the al-3 gene. Wc-1 and wc-2 interact via homologous PAS domains, bind to promoters of light regulated genes such as frq, and activate transcription. May bind directly to frq.
messages: Nucleus

367110:NCU01305
gene id: 367110:NCU01305
uniprot id: Q1K7W1
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03779
gene id: 367110:NCU03779
uniprot id: Q1K7A2
names: Function
names: Similarity
messages: Belongs to the dihydroxyacetone kinase (DAK) family.
messages: Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.

367110:NCU01468
gene id: 367110:NCU01468
uniprot id: Q7RXW3
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

367110:NCU03820
gene id: 367110:NCU03820
uniprot id: V5ILG7
names: Similarity
messages: Belongs to the HUS1 family.

367110:NCU00680
gene id: 367110:NCU00680
uniprot id: Q7SHX3
names: Similarity
messages: Belongs to the PrpD family.

367110:NCU08375
gene id: 367110:NCU08375
uniprot id: Q7SGP0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by UBA4. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.
messages: Belongs to the MoaD family. MOCS2A subfamily.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.
messages: Cytoplasm
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.

367110:NCU09118
gene id: 367110:NCU09118
uniprot id: V5IPM9
uniprot id: V5IQ16
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

367110:NCU04252
gene id: 367110:NCU04252
uniprot id: Q1K7I9
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

367110:NCU07870
gene id: 367110:NCU07870
uniprot id: Q7SBT9
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

367110:NCU00880
gene id: 367110:NCU00880
uniprot id: Q7SFF1
names: Subcellular Location Annotation
messages: Cytoplasm

367110:NCU02887
gene id: 367110:NCU02887
uniprot id: Q7SHL7
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

367110:NCU04841
gene id: 367110:NCU04841
uniprot id: Q7S6J4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the STAM family.
messages: Component of the ESCRT-0 complex composed of hse1 and vps27.
messages: Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).
messages: Endosome membrane

367110:NCU07823
gene id: 367110:NCU07823
uniprot id: Q7SBE1
names: Similarity
messages: Belongs to the scytalone dehydratase family.

367110:NCU09189
gene id: 367110:NCU09189
uniprot id: Q7S326
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
messages: telomere

367110:NCU01700
gene id: 367110:NCU01700
uniprot id: Q7RY22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMN family.
messages: Cytoplasm
messages: gem

367110:NCU07728
gene id: 367110:NCU07728
uniprot id: Q1K8E7
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Both the N-terminal and C-terminal zinc fingers are involved in DNA-binding, although the C-terminal finger plays a more important role in the binding (PubMed:10194352).
messages: Derepresses siderophore biosynthesis in high iron concentrations (PubMed:9790585).
messages: GATA-type transcription repressor that regulates iron- acquisition genes through specific binding the GATA sequence elements of target promoters in a zinc-dependent manner (PubMed:9790585, PubMed:10194352, PubMed:12484767). Iron acquisition regulation is critical for survival under both iron-limiting conditions (to acquire essential iron) and iron-replete conditions (to limit iron toxicity) (PubMed:10194352). Represses the synthesis of siderophores in high iron conditions (PubMed:9790585).
messages: Nucleus
messages: The conserved cystein-rich region (CRR) localized between the zinc fingers is also involved in DNA-binding and transcription repressor activity (PubMed:12484767).
messages: The promoter contains a number of GATA sequences; however, expression occurs in a constitutive fashion and is not regulated by the concentration of iron available to the cells (PubMed:9790585).

367110:NCU03395
gene id: 367110:NCU03395
uniprot id: P53659
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity). This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector (By similarity). Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores (By similarity).
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).
messages: Vacuole membrane

367110:NCU02117
gene id: 367110:NCU02117
uniprot id: Q7SCY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: May be involved in cellular response to stress. Required to maintain mitochondrial DNA (mtDNA) integrity and stability (By similarity).
messages: Mitochondrion inner membrane

367110:NCU02252
gene id: 367110:NCU02252
uniprot id: Q7S5B2
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family.

367110:NCU07722
gene id: 367110:NCU07722
uniprot id: Q7S8R7
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

367110:NCU06949
gene id: 367110:NCU06949
uniprot id: Q7S0X5
names: Similarity
messages: Belongs to the peptidase S8 family.

367110:NCU10155
gene id: 367110:NCU10155
uniprot id: Q7S126
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase epsilon subunit B family.
messages: Nucleus

367110:NCU05280
gene id: 367110:NCU05280
uniprot id: Q7S8K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex ASK1 family.
messages: Nucleus
messages: kinetochore
messages: spindle

367110:NCU11399
gene id: 367110:NCU11399
uniprot id: A7UXA5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

367110:NCU07528
gene id: 367110:NCU07528
uniprot id: U9W3P8
uniprot id: U9WH94
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

367110:NCU17186
gene id: 367110:NCU17186
uniprot id: V5IMB7
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
messages: In the C-terminal section; belongs to the MoeA family.

367110:NCU07754
gene id: 367110:NCU07754
uniprot id: Q7S1S4
names: Subcellular Location Annotation
messages: Membrane

367110:NCU16005
gene id: 367110:NCU16005
uniprot id: P23351
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane (Probable). uS3m is essential for mitochondrial protein synthesis and required for the maturation of small ribosomal subunits (By similarity).
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins. uS3m, uS4m and uS5m form the narrow entry site of the mRNA channel.
messages: Mitochondrion

367110:NCU07783
gene id: 367110:NCU07783
uniprot id: Q7S256
names: Similarity
messages: Belongs to the complex I LYR family.

367110:NCU05078
gene id: 367110:NCU05078
uniprot id: Q7RWK6
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

367110:NCU02980
gene id: 367110:NCU02980
uniprot id: Q1K947
names: Subcellular Location Annotation
messages: Membrane

367110:NCU02788
gene id: 367110:NCU02788
uniprot id: Q7SD74
names: Similarity
messages: Belongs to the synembryn family.

367110:NCU04201
gene id: 367110:NCU04201
uniprot id: Q1K7D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYG1 (TC 2.A.94) family.
messages: Membrane

367110:NCU16015
gene id: 367110:NCU16015
uniprot id: P0CY43
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Encoded from partially processed cob mRNA that terminates with the in-frame coding sequence of the third intron.
messages: In the C-terminal section; belongs to the LAGLIDADG endonuclease family.
messages: In the N-terminal section; belongs to the cytochrome b family.
messages: Mitochondrial mRNA maturase required for splicing of intron 3 of the cytochrome b (cob) gene, containing its own coding sequence.
messages: Mitochondrion inner membrane

367110:NCU03151
gene id: 367110:NCU03151
uniprot id: Q7SDU1
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

367110:NCU00606
gene id: 367110:NCU00606
uniprot id: Q7SI45
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU08298
gene id: 367110:NCU08298
uniprot id: Q7SA89
names: Similarity
messages: Belongs to the lysophospholipase family.

367110:NCU06360
gene id: 367110:NCU06360
uniprot id: Q7S9U6
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

367110:NCU01269
gene id: 367110:NCU01269
uniprot id: Q7S7C3
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

367110:NCU02919
gene id: 367110:NCU02919
uniprot id: Q7SHI5
names: Caution
names: Function
names: Induction
names: Similarity
messages: A recent genetics report associated srdA and its cluster with the biosynthesis of furanocoumarin neurosporin A, a metabolite produced by N.crassa for chemoresistance against predation by arthropod fungivores (PubMed:28485098). However, based on the gene cluster organization and predicted gene functions, this cluster is unlikely to be involved in neurosporin A biosynthesis, but instead produces compounds similar to pyriculol (PubMed:30908040).
messages: Belongs to the virC family.
messages: Cupin-domain-containing oxidoreductase; part of the gene cluster that mediates the biosynthesis of sordarial, a salicylic aldehyde structurally related to the phytotoxin pyriculol (PubMed:19277664, PubMed:28485098, PubMed:30908040). The most interesting aspect of this pathway is formation of an aromatic product from the highly reducing polyketide synthase srdA (PubMed:30908040). SrdA synthesizes a reduced polyketide chain from one molecule of acetyl-CoA and five molecules of malonyl-CoA (PubMed:30908040). The polyketide chain is then reductively released as an aldehyde (PubMed:30908040). The oxidoreductases srdC, srdD and srdE then oxidize one of the hydroxy groups to facilitate the intramolecular aldol condensation, followed by dehydration to yield a salicylic aldehyde (PubMed:30908040). This aldehyde can undergo facile reduction by endogenous reductases to yield the alcohol 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene (PubMed:30908040). The flavin-dependent srdI counteract against the propensity of the aldehydes to be reduced under physiological conditions and is responsible for reoxidizing 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene back to the salicylic aldehyde (PubMed:30908040). This salicylic aldehyde is then selectively epoxidized by the cupin-domain-containing oxidoreductase srdB to yield the epoxide, which can be hydrolyzed stereoselectively by the hydrolase srdG to give the final product sordarial (PubMed:30908040).
messages: Expression is up-regulated during sexual development (PubMed:19277664). Expression is also up-regulated during confrontation with the arthropod fungivore Drosophila melanogaster (PubMed:28485098).

367110:NCU04767
gene id: 367110:NCU04767
uniprot id: Q7S641
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the putative lipase ROG1 family.
messages: Membrane

367110:NCU09539
gene id: 367110:NCU09539
uniprot id: Q7S2C2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Mitochondrion

367110:NCU07914
gene id: 367110:NCU07914
uniprot id: P38667
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

367110:NCU03464
gene id: 367110:NCU03464
uniprot id: Q1K4U1
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU05598
gene id: 367110:NCU05598
uniprot id: P78710
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 4 family.
messages: Could be a pectinolytic enzyme that hydrolyzes the alpha-L-rhamnopyranosyl-(1,4)-alpha-D-galacturonopyranosyl glycosidic linkage by beta-elimination, thereby generating oligosaccharides terminating at the non-reducing end with a hex-4-enopyranosyluronic acid residue.
messages: Expressed preferentially during the sexual cycle and essential for normal sexual development.
messages: Secreted

367110:NCU08353
gene id: 367110:NCU08353
uniprot id: Q7SGR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.
messages: Nucleus

367110:NCU02079
gene id: 367110:NCU02079
uniprot id: Q7SEY5
names: Function
names: Similarity
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

367110:NCU04790
gene id: 367110:NCU04790
uniprot id: V5IKM0
uniprot id: V5IKU8
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

367110:NCU00678
gene id: 367110:NCU00678
uniprot id: Q7SHX5
names: Similarity
messages: Belongs to the group II decarboxylase family.

367110:NCU00472
gene id: 367110:NCU00472
uniprot id: Q7RXX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

367110:NCU01104
gene id: 367110:NCU01104
uniprot id: Q7S806
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

367110:NCU04331
gene id: 367110:NCU04331
uniprot id: O59953
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Component of the large ribosomal subunit (LSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

367110:NCU04446
gene id: 367110:NCU04446
uniprot id: Q7RZ28
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06300
gene id: 367110:NCU06300
uniprot id: Q7SAD0
names: Similarity
messages: Belongs to the guanylate kinase family.

367110:NCU07478
gene id: 367110:NCU07478
uniprot id: Q7SCR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

367110:NCU09469
gene id: 367110:NCU09469
uniprot id: Q7SC12
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.
messages: Component of the PAN1 actin cytoskeleton-regulatory complex.
messages: Endosome membrane
messages: Membrane
messages: actin patch

367110:NCU01321
gene id: 367110:NCU01321
uniprot id: Q1K7V0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus

367110:NCU06306
gene id: 367110:NCU06306
uniprot id: Q7SAC4
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU00302
gene id: 367110:NCU00302
uniprot id: Q7RZR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).
messages: Endoplasmic reticulum membrane

367110:NCU10904
gene id: 367110:NCU10904
uniprot id: A7UWG6
names: Similarity
messages: Belongs to the IMPACT family.

367110:NCU05295
gene id: 367110:NCU05295
uniprot id: Q7S903
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

367110:NCU07041
gene id: 367110:NCU07041
uniprot id: Q7S995
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.
messages: nucleolus

367110:NCU05883
gene id: 367110:NCU05883
uniprot id: V5ILU3
names: Similarity
messages: Belongs to the NtaA/SnaA/DszA monooxygenase family.

367110:NCU03911
gene id: 367110:NCU03911
uniprot id: Q9P5K9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: Cytoplasm
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
messages: Heterodimer of an alpha and a beta subunit.

367110:NCU00276
gene id: 367110:NCU00276
uniprot id: Q9Y767
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-A family.
messages: In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.
messages: Involved in the replication of mitochondrial DNA.
messages: Mitochondrion

367110:NCU05414
gene id: 367110:NCU05414
uniprot id: F5HAA2
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU02909
gene id: 367110:NCU02909
uniprot id: Q7SHJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 75 family.
messages: Chitosanase catalyzing the endo-type cleavage of chitosan, the deacylated form of chitin. Chitosanase may be crucial in the degradation of the deacetylated portion of chitin in the fungal cell wall.
messages: Secreted

367110:NCU06771
gene id: 367110:NCU06771
uniprot id: Q1K8Z8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

367110:NCU06021
gene id: 367110:NCU06021
uniprot id: Q7S4F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR55 family.
messages: nucleolus

367110:NCU00959
gene id: 367110:NCU00959
uniprot id: V5IQY5
uniprot id: V5IRP1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.
messages: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

367110:NCU00122
gene id: 367110:NCU00122
uniprot id: Q7RYK7
names: Similarity
messages: Belongs to the peptidase M18 family.

367110:NCU07517
gene id: 367110:NCU07517
uniprot id: Q7S1A3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
messages: Membrane

367110:NCU02156
gene id: 367110:NCU02156
uniprot id: Q7SER0
names: Similarity
messages: Belongs to the PDCD5 family.

367110:NCU05218
gene id: 367110:NCU05218
uniprot id: Q7S9B6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autoacetylation at Lys-320 is required for proper function.
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z (By similarity). Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac (By similarity). The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination (By similarity). Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins (By similarity). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively (By similarity).
messages: Chromosome
messages: Component of the NuA4 histone acetyltransferase complex.
messages: Nucleus
messages: The ESA1-RPD3 motif is common to ESA1 and RPD3 and is required for ESA1 histone acetyl-transferase (HAT) activity and RPD3 histone deacetylase (HDAC) activity.

367110:NCU09456
gene id: 367110:NCU09456
uniprot id: Q7S0M1
names: Similarity
messages: Belongs to the FMO family.

367110:NCU03767
gene id: 367110:NCU03767
uniprot id: Q1K7B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

367110:NCU08924
gene id: 367110:NCU08924
uniprot id: Q1K6J3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

367110:NCU02566
gene id: 367110:NCU02566
uniprot id: Q7SHP9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm
messages: Mitochondrion
messages: Monomer.

367110:NCU07839
gene id: 367110:NCU07839
uniprot id: Q7SBC6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.
messages: Associates with polysomes.
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

367110:NCU02366
gene id: 367110:NCU02366
uniprot id: Q7S4W0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Mitochondrion

367110:NCU07925
gene id: 367110:NCU07925
uniprot id: V5IN46
names: Function
names: Similarity
messages: Belongs to the POA1 family.
messages: Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing.

367110:NCU03659
gene id: 367110:NCU03659
uniprot id: Q1K6P8
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

367110:NCU09869
gene id: 367110:NCU09869
uniprot id: V5ILH3
uniprot id: V5IM27
names: Similarity
messages: Belongs to the SEC3 family.

367110:NCU00183
gene id: 367110:NCU00183
uniprot id: Q7RXA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Belongs to the NDUFAF7 family.
messages: Mitochondrion

367110:NCU05194
gene id: 367110:NCU05194
uniprot id: Q7S9D8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

367110:NCU08899
gene id: 367110:NCU08899
uniprot id: Q1K694
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
messages: Expression is induced by ketoconazole treatment.
messages: Increases azole susceptibility (PubMed:33199382). Reduces the transcriptional response by cdr4 to ketoconazole stress and increased cellular ketoconazole accumulation under ketoconazole stress (PubMed:33199382). Decreases the ergosterol production but accumulates lanosterol (PubMed:33199382).
messages: Nucleus
messages: Transcription factor involved in azole responses (PubMed:33199382). Positively regulates the expression of azole efflux pump cdr4 (PubMed:33199382). Also regulates the transcriptional response of the azole target gene erg11 to ketoconazole (PubMed:33199382).

367110:NCU09610
gene id: 367110:NCU09610
uniprot id: Q9P5X6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
messages: Cooperates with the reticulon proteins and tubule-shaping DP1 family proteins to generate and maintain the structure of the tubular endoplasmic reticulum network. Has GTPase activity, which is required for its function in ER organization.
messages: Endoplasmic reticulum membrane

367110:NCU06738
gene id: 367110:NCU06738
uniprot id: Q873A1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SEC31 family.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
messages: Endoplasmic reticulum membrane
messages: The COPII coat is composed of at least 5 proteins: the sec23/24 complex, the sec13/31 complex, and the protein vtr-7/sar1. Sec13 and sec31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with nup-20/sec13 (By similarity).

367110:NCU09304
gene id: 367110:NCU09304
uniprot id: Q7S1H7
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

367110:NCU03187
gene id: 367110:NCU03187
uniprot id: P48479
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accumulates when cells are arrested in G2; degraded as cells traverse mitosis.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Nucleus
messages: Protein kinase that plays an important role in mitotic regulation.

367110:NCU02435
gene id: 367110:NCU02435
uniprot id: P37210
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by gcn-5 to form H2BK11ac and H2BK16ac. H2BK16ac can also be formed by esa-1. Acetylation of N-terminal lysines and particularly formation of H2BK11acK16ac has a positive effect on transcription (By similarity).
messages: Belongs to the histone H2B family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Monoubiquitinated by the ubc-2-bre-1 complex to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for H3K4me and H3K79me formation. H2BK123ub1 also modulates the formation of double-strand breaks during meiosis and is a prerequisite for DNA-damage checkpoint activation (By similarity).
messages: Nucleus
messages: Phosphorylated by ste-20 to form H2BS10ph during progression through meiotic prophase. May be correlated with chromosome condensation (By similarity).
messages: Sumoylation to form H2BK6su or H2BK7su, and probably also H2BK16su or H2BK17su, occurs preferentially near the telomeres and represses gene transcription.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2BK6ac = acetylated Lys-8; H2BK6su = sumoylated Lys-8; H2BK7ac = acetylated Lys-9; H2BK7su = sumoylated Lys-9; H2BS10ph = phosphorylated Ser-12; H2BK11ac = acetylated Lys-13; H2BK16ac = acetylated Lys-24; H2BK16su = sumoylated Lys-24; H2BK17su = sumoylated Lys-25; H2BK123ub1 = monoubiquitinated Lys-131.

367110:NCU05305
gene id: 367110:NCU05305
uniprot id: Q7S8Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Nucleus

367110:NCU16656
gene id: 367110:NCU16656
uniprot id: U9W4T9
uniprot id: U9WGN9
names: Similarity
messages: Belongs to the importin beta family.

367110:NCU03168
gene id: 367110:NCU03168
uniprot id: Q7SEW4
names: Similarity
messages: Belongs to the peptidase A1 family.

367110:NCU05210
gene id: 367110:NCU05210
uniprot id: P33288
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAD18 family.
messages: E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme mus-8/ubc2 to form the mus-8/ubc2-uvs-2/rad18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.
messages: Interacts with E2 mus-8/ubc2, forming a complex with ubiquitin ligase activity.
messages: Nucleus

367110:NCU04419
gene id: 367110:NCU04419
uniprot id: Q7RZ55
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

367110:NCU04626
gene id: 367110:NCU04626
uniprot id: Q7S075
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06284
gene id: 367110:NCU06284
uniprot id: Q7SAE6
names: Function
names: Similarity
messages: Belongs to the VPS35 family.
messages: Plays a role in vesicular protein sorting.

367110:NCU01429
gene id: 367110:NCU01429
uniprot id: Q7RWH9
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.

367110:NCU06022
gene id: 367110:NCU06022
uniprot id: P11634
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.
messages: Does not affect carbon mediated repression of qa-2 and qa-y.
messages: Expression is induced in the presence of quinic acid (PubMed:6458044). The quinic acid (qa) gene cluster is subject to two levels of gene control: a primary system which responds to the presence of quinic acid via the qa-1S repressor protein that blocks the qa-1F activator, and a secondary system which represses transcription of qa genes in the presence of a preferred carbon source such as glucose (PubMed:6458044, PubMed:12477937, PubMed:17597928, PubMed:19236936).
messages: Part of the qa gene cluster that mediates the catabolism of quinic acid (QA) and as such, allows the use of QA as a sole carbon source (PubMed:2525625, PubMed:6458044, PubMed:19236936). Its function within the pathway has not been determined yet but it probably plays a regulatory role (PubMed:19236936). The qa cluster encodes 3 inducible enymes (qa-2, qa-3 and qa-4) catalyzing the first three reactions in the catabolism of quinic acid to protocatechuic acid (also known as 3,4-Dihydroxybenzoic acid) (Probable).

367110:NCU01160
gene id: 367110:NCU01160
uniprot id: Q8X0X2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription (By similarity).
messages: Associates with the nuclear pore complex.
messages: Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.
messages: Cytoplasm
messages: Nucleus membrane
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nuclear pore complex

367110:NCU08951
gene id: 367110:NCU08951
uniprot id: Q1K6L4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.

367110:NCU00181
gene id: 367110:NCU00181
uniprot id: Q7RXA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.
messages: May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.
messages: Nucleus

367110:NCU09161
gene id: 367110:NCU09161
uniprot id: Q7S354
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290). In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.
messages: Cytoplasm

367110:NCU07960
gene id: 367110:NCU07960
uniprot id: Q7S925
names: Subcellular Location Annotation
messages: Membrane

367110:NCU08011
gene id: 367110:NCU08011
uniprot id: Q7SAN0
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

367110:NCU06875
gene id: 367110:NCU06875
uniprot id: Q7S3H8
names: Similarity
messages: Belongs to the MOG1 family.

367110:NCU03117
gene id: 367110:NCU03117
uniprot id: Q7SFX7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

367110:NCU04649
gene id: 367110:NCU04649
uniprot id: Q1K6G6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

367110:NCU02727
gene id: 367110:NCU02727
uniprot id: Q7SGC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

367110:NCU04943
gene id: 367110:NCU04943
uniprot id: Q7S3S4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BOS1 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: SNARE required for protein transport between the ER and the Golgi complex.

367110:NCU02224
gene id: 367110:NCU02224
uniprot id: Q7S4G9
names: Similarity
messages: Belongs to the proteasome subunit S3 family.

367110:NCU16019
gene id: 367110:NCU16019
uniprot id: Q36580
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Encoded within intron 1 of ndh-1.
messages: Mitochondrial DNA endonuclease involved in intron homing.
messages: Mitochondrion
messages: To endonucleases of group I introns of fungi and phage.

367110:NCU09315
gene id: 367110:NCU09315
uniprot id: P20824
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds DNA as a dimer.
messages: Factor that activates the transcription of structural genes for phosphorus acquisition.
messages: Nucleus

367110:NCU05244
gene id: 367110:NCU05244
uniprot id: Q7S8U1
names: Similarity
messages: Belongs to the thioesterase PaaI family.

367110:NCU09866
gene id: 367110:NCU09866
uniprot id: V5IL22
uniprot id: V5ILM2
uniprot id: V5IM79
uniprot id: V5INC2
names: Similarity
messages: Belongs to the UPL family. K-HECT subfamily.

367110:NCU09245
gene id: 367110:NCU09245
uniprot id: Q7SF65
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

367110:NCU05251
gene id: 367110:NCU05251
uniprot id: Q7S892
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

367110:NCU00829
gene id: 367110:NCU00829
uniprot id: Q7SEA5
names: Subcellular Location Annotation
messages: Membrane

367110:NCU01190
gene id: 367110:NCU01190
uniprot id: Q1K847
names: Similarity
messages: Belongs to the GET4 family.

367110:NCU06766
gene id: 367110:NCU06766
uniprot id: Q7SCC1
names: Function
names: Induction
names: Similarity
messages: Belongs to the helicase family. Dicer subfamily.
messages: By double-stranded RNA (dsRNA).
messages: Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons. Controls the expression of the non-LTR retrotransposon Tad in the African strain, Adiomopoume.

367110:NCU04856
gene id: 367110:NCU04856
uniprot id: V5ILU9
uniprot id: V5INM7
names: Similarity
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Homooctamer.

367110:NCU01918
gene id: 367110:NCU01918
uniprot id: Q7SH88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC4 family.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
messages: actin patch

367110:NCU03047
gene id: 367110:NCU03047
uniprot id: Q7SD24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF beta subunit family.
messages: Nucleus

367110:NCU06370
gene id: 367110:NCU06370
uniprot id: Q7S9T6
names: Similarity
messages: Belongs to the synaptobrevin family.

367110:NCU10987
gene id: 367110:NCU10987
uniprot id: A7UW65
names: Subcellular Location Annotation
messages: Membrane

367110:NCU05001
gene id: 367110:NCU05001
uniprot id: V5IL49
names: Similarity
messages: Belongs to the cytochrome P450 family.

367110:NCU03798
gene id: 367110:NCU03798
uniprot id: Q9C1E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex, whose core is composed of TIM22 and TIM54, associated with the 70 kDa heterohexamer composed of TIM9 and TIM10 (or TIM8 and TIM13).
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).
messages: Mitochondrion inner membrane

367110:NCU08626
gene id: 367110:NCU08626
uniprot id: P27526
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 5,10-methenyltetrahydrofolate (MTHF) non-covalently per subunit.
messages: Binds 1 FAD per subunit.
messages: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation.
messages: Monomer.

367110:NCU00346
gene id: 367110:NCU00346
uniprot id: Q7RZL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU16767
gene id: 367110:NCU16767
uniprot id: V5IMA9
names: Similarity
messages: Belongs to the DCC1 family.

367110:NCU10051
gene id: 367110:NCU10051
uniprot id: Q7S074
names: Similarity
messages: Belongs to the globin family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

367110:NCU02925
gene id: 367110:NCU02925
uniprot id: Q7SHH9
names: Caution
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
messages: A recent genetics report associated srdA and its cluster with the biosynthesis of furanocoumarin neurosporin A, a metabolite produced by N.crassa for chemoresistance against predation by arthropod fungivores (PubMed:28485098). However, based on the gene cluster organization and predicted gene functions, this cluster is unlikely to be involved in neurosporin A biosynthesis, but instead produces compounds similar to pyriculol (PubMed:30908040).
messages: Belongs to the paxM FAD-dependent monooxygenase family.
messages: Expression is up-regulated during sexual development (PubMed:19277664). Expression is also up-regulated during confrontation with the arthropod fungivore Drosophila melanogaster (PubMed:28485098).
messages: Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of sordarial, a salicylic aldehyde structurally related to the phytotoxin pyriculol (PubMed:19277664, PubMed:28485098, PubMed:30908040). The most interesting aspect of this pathway is formation of an aromatic product from the highly reducing polyketide synthase srdA (PubMed:30908040). SrdA synthesizes a reduced polyketide chain from one molecule of acetyl-CoA and five molecules of malonyl-CoA (PubMed:30908040). The polyketide chain is then reductively released as an aldehyde (PubMed:30908040). The oxidoreductases srdC, srdD and srdE then oxidize one of the hydroxy groups to facilitate the intramolecular aldol condensation, followed by dehydration to yield a salicylic aldehyde (PubMed:30908040). This aldehyde can undergo facile reduction by endogenous reductases to yield the alcohol 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene (PubMed:30908040). The flavin-dependent srdI counteract against the propensity of the aldehydes to be reduced under physiological conditions and is responsible for reoxidizing 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene back to the salicylic aldehyde (PubMed:30908040). This salicylic aldehyde is then selectively epoxidized by the cupin-domain-containing oxidoreductase srdB to yield the epoxide, which can be hydrolyzed stereoselectively by the hydrolase srdG to give the final product sordarial (PubMed:30908040).
messages: Leads to a delay in fruiting body maturation.

367110:NCU08739
gene id: 367110:NCU08739
uniprot id: Q7SCF6
names: Similarity
messages: Belongs to the peptidase A1 family.

367110:NCU03834
gene id: 367110:NCU03834
uniprot id: Q7S747
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enhancer of polycomb family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M (By similarity).
messages: Component of the NuA4 histone acetyltransferase complex.
messages: Nucleus

367110:NCU02496
gene id: 367110:NCU02496
uniprot id: Q7SG68
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

367110:NCU06787
gene id: 367110:NCU06787
uniprot id: Q1K8Y6
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU07742
gene id: 367110:NCU07742
uniprot id: Q7S0V0
names: Similarity
messages: Belongs to the NAD kinase family.

367110:NCU08427
gene id: 367110:NCU08427
uniprot id: Q1K8P6
names: Similarity
messages: Belongs to the activator 1 small subunits family.

367110:NCU02616
gene id: 367110:NCU02616
uniprot id: Q7SG04
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

367110:NCU11222
gene id: 367110:NCU11222
uniprot id: A7UW23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNU66/SART1 family.
messages: Nucleus

367110:NCU09215
gene id: 367110:NCU09215
uniprot id: V5IQV5
names: Subcellular Location Annotation
messages: Membrane
messages: Vacuole membrane

367110:NCU10847
gene id: 367110:NCU10847
uniprot id: A7UVY0
names: Similarity
messages: Belongs to the acetyltransferase family. GCN5 subfamily.

367110:NCU05554
gene id: 367110:NCU05554
uniprot id: Q7S709
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

367110:NCU07992
gene id: 367110:NCU07992
uniprot id: Q7SAP8
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU00216
gene id: 367110:NCU00216
uniprot id: Q7RXL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Mitochondrion outer membrane
messages: Monomer. Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of dph1, dph2, dph3 and a NADH-dependent reductase, predominantly cbr1.
messages: NADH-dependent reductase for dph3 and cytochrome b5. Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. Dph1 and dph2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising dph3 and a NADH-dependent reductase, predominantly cbr1. By reducing dph3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.

367110:NCU02203
gene id: 367110:NCU02203
uniprot id: Q7S469
names: Similarity
messages: Belongs to the ZNF598/HEL2 family.

367110:NCU06970
gene id: 367110:NCU06970
uniprot id: V5IML6
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

367110:NCU01404
gene id: 367110:NCU01404
uniprot id: Q7S731
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

367110:NCU03628
gene id: 367110:NCU03628
uniprot id: Q1K7Q6
names: Subcellular Location Annotation
messages: nucleolus

367110:NCU01744
gene id: 367110:NCU01744
uniprot id: V5IN94
names: Cofactor
names: Similarity
messages: Belongs to the glutamate synthase family.
messages: Binds 1 [3Fe-4S] cluster.

367110:NCU01563
gene id: 367110:NCU01563
uniprot id: Q9HE63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin family. Cyclin C subfamily.
messages: Component of the srb8-11 complex, a regulatory module of the Mediator complex.
messages: Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The srb8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).
messages: Nucleus

367110:NCU00067
gene id: 367110:NCU00067
uniprot id: Q7RX83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.

367110:NCU00059
gene id: 367110:NCU00059
uniprot id: Q7RW40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RIX1/PELP1 family.
messages: Nucleus

367110:NCU03782
gene id: 367110:NCU03782
uniprot id: V5IL63
uniprot id: V5ILF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Nucleus

367110:NCU06719
gene id: 367110:NCU06719
uniprot id: Q1K6X2
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

367110:NCU05221
gene id: 367110:NCU05221
uniprot id: P25711
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS4 subunit family.
messages: Complex I is composed of about 40 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: It is uncertain whether Met-1 or Met-14 is the initiator.
messages: Mitochondrion inner membrane

367110:NCU06742
gene id: 367110:NCU06742
uniprot id: Q1K8U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDE2 family.
messages: Cytoplasm
messages: Nucleus

367110:NCU06778
gene id: 367110:NCU06778
uniprot id: Q1K8Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

367110:NCU03515
gene id: 367110:NCU03515
uniprot id: Q1K4P2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

367110:NCU16806
gene id: 367110:NCU16806
uniprot id: V5IQ84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

367110:NCU09055
gene id: 367110:NCU09055
uniprot id: Q7S1U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBT5 family.
messages: Membrane

367110:NCU09653
gene id: 367110:NCU09653
uniprot id: Q7S270
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

367110:NCU04463
gene id: 367110:NCU04463
uniprot id: Q7RYE4
names: Similarity
messages: Belongs to the non-repetitive/WGA-negative nucleoporin family.

367110:NCU02579
gene id: 367110:NCU02579
uniprot id: Q6MV78
names: Subcellular Location Annotation
messages: Vacuole

367110:NCU03134
gene id: 367110:NCU03134
uniprot id: Q7SDV6
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

367110:NCU08946
gene id: 367110:NCU08946
uniprot id: Q1K6R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Mitochondrion inner membrane

367110:NCU08807
gene id: 367110:NCU08807
uniprot id: O59958
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the creA/MIG C2H2-type zinc-finger protein family.
messages: Involved in carbon catabolite repression. Represses the transcription of a number of genes by binding to a GC-rich region in their promoter (By similarity).
messages: Nucleus

367110:NCU04796
gene id: 367110:NCU04796
uniprot id: Q7S6N9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

367110:NCU00424
gene id: 367110:NCU00424
uniprot id: Q7RVP8
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU00453
gene id: 367110:NCU00453
uniprot id: Q7RXZ1
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

367110:NCU17240
gene id: 367110:NCU17240
uniprot id: V5IKM3
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase. Interacts with DNA in a non-specific manner.

367110:NCU03603
gene id: 367110:NCU03603
uniprot id: Q8X0J4
names: Similarity
messages: Belongs to the cytochrome b5 family.

367110:NCU08323
gene id: 367110:NCU08323
uniprot id: Q7SA65
names: Similarity
messages: Belongs to the bystin family.

367110:NCU02090
gene id: 367110:NCU02090
uniprot id: Q7SCM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

367110:NCU08633
gene id: 367110:NCU08633
uniprot id: Q7SFI8
names: Similarity
messages: Belongs to the CACTIN family.

367110:NCU02437
gene id: 367110:NCU02437
uniprot id: Q8X132
names: Caution
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated by esa-1 to form H2AK4ac and H2AK7ac.
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: In contrast to vertebrates and insects, its C-terminus is not monoubiquitinated.
messages: Nucleus
messages: Phosphorylated to form H2AS128ph (gamma-H2A) in response to DNA double-strand breaks (DSBs) generated by exogenous genotoxic agents and by stalled replication forks. Phosphorylation is dependent on the DNA damage checkpoint kinases mec-1/ATR and tel-1/ATM, spreads on either side of a detected DSB site and may mark the surrounding chromatin for recruitment of proteins required for DNA damage signaling and repair. Gamma-H2A is removed from the DNA prior to the strand invasion-primer extension step of the repair process and subsequently dephosphorylated. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint (By similarity).
messages: The [ST]-Q motif constitutes a recognition sequence for kinases from the PI3/PI4-kinase family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
messages: To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2AK4ac = acetylated Lys-6; H2AK7ac = acetylated Lys-10; H2AS128ph = phosphorylated Ser-131.

367110:NCU09674
gene id: 367110:NCU09674
uniprot id: Q1K6Q9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

367110:NCU02188
gene id: 367110:NCU02188
uniprot id: Q7S4D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU00865
gene id: 367110:NCU00865
uniprot id: Q7SFG6
names: Cofactor
messages: Binds 2 manganese ions per subunit.

367110:NCU03340
gene id: 367110:NCU03340
uniprot id: Q1K528
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 11 subunits. The complex is composed of a catalytic core of 3 subunits Cox1, Cox2 and Cox3, encoded in the mitochondrial DNA, and 8 supernumerary subunits Cox4, Cox5a/Cox5, Cox6, Cox7, Cox8, Cox7a/Cox9, Cox6b/Cox12 and Cox6a/Cox13, which are encoded in the nuclear genome (PubMed:31316820). The complex exists as a monomer or a dimer and forms respiratory supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in various different assemblies (supercomplexes I(1)IV(1), I(1)III(3)IV(2), III(2)IV(1) and III(2)IV(2) as well as larger supercomplexes of compositions like I(1)III(2)IV(5-6)) (PubMed:17873079).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of Cox2 and heme A of Cox1 to the active site in Cox1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

367110:NCU01374
gene id: 367110:NCU01374
uniprot id: Q1K708
names: Similarity
messages: Belongs to the CutC family.

367110:NCU01119
gene id: 367110:NCU01119
uniprot id: Q1K768
names: Similarity
messages: Belongs to the terpene cyclase/mutase family.

367110:NCU06764
gene id: 367110:NCU06764
uniprot id: Q8X077
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).
messages: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).

367110:NCU03071
gene id: 367110:NCU03071
uniprot id: Q1K904
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

367110:NCU01672
gene id: 367110:NCU01672
uniprot id: Q1K5H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMCO4 family.
messages: Membrane

367110:NCU01984
gene id: 367110:NCU01984
uniprot id: Q7SE76
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU01992
gene id: 367110:NCU01992
uniprot id: Q7SFN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

367110:NCU07989
gene id: 367110:NCU07989
uniprot id: Q7SAQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit APL3 and beta-type subunit APL1), a medium chain (mu-type subunit APM4) and a small adaptin (sigma-type subunit APS2).
messages: Belongs to the adaptor complexes small subunit family.
messages: Cell membrane
messages: Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity).
messages: coated pit

367110:NCU09700
gene id: 367110:NCU09700
uniprot id: Q7S2S6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.

367110:NCU04110
gene id: 367110:NCU04110
uniprot id: Q8NIW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBP/SF1 family.
messages: Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns (By similarity).
messages: Nucleus

367110:NCU04234
gene id: 367110:NCU04234
uniprot id: Q7RVV0
names: Similarity
messages: Belongs to the cytochrome P450 family.

367110:NCU06228
gene id: 367110:NCU06228
uniprot id: Q7SBS7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

367110:NCU01517
gene id: 367110:NCU01517
uniprot id: P14804
names: Similarity
messages: Belongs to the glycosyl hydrolase 15 family.

367110:NCU00614
gene id: 367110:NCU00614
uniprot id: Q7SI37
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC1 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU04887
gene id: 367110:NCU04887
uniprot id: Q7S1E8
names: Similarity
messages: Belongs to the MNN1/MNT family.

367110:NCU07720
gene id: 367110:NCU07720
uniprot id: Q7S8R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

367110:NCU00041
gene id: 367110:NCU00041
uniprot id: Q7RWT0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: G proteins are composed of 3 units, alpha, beta and gamma.
messages: Membrane

367110:NCU11246
gene id: 367110:NCU11246
uniprot id: A7UW80
names: Similarity
messages: Belongs to the COG4 family.

367110:NCU07727
gene id: 367110:NCU07727
uniprot id: Q7S8R2
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03973
gene id: 367110:NCU03973
uniprot id: Q7RZ96
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

367110:NCU07913
gene id: 367110:NCU07913
uniprot id: Q7SA04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DSS1/SEM1 family.
messages: Part of the 26S proteasome.
messages: Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis.

367110:NCU04140
gene id: 367110:NCU04140
uniprot id: P20080
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
messages: Binds to the immunosuppressant drug FK506.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

367110:NCU02612
gene id: 367110:NCU02612
uniprot id: Q7SG08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TEC1 family.
messages: Nucleus

367110:NCU16784
gene id: 367110:NCU16784
uniprot id: V5IME2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
messages: Membrane
messages: Regulates also the sphingolipid metabolism.

367110:NCU04334
gene id: 367110:NCU04334
uniprot id: Q7RX42
names: Similarity
messages: Belongs to the GroES chaperonin family.

367110:NCU07188
gene id: 367110:NCU07188
uniprot id: Q1K5V5
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.

367110:NCU04942
gene id: 367110:NCU04942
uniprot id: Q7S3S5
names: Subcellular Location Annotation
messages: Membrane

367110:NCU09792
gene id: 367110:NCU09792
uniprot id: Q7S601
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06654
gene id: 367110:NCU06654
uniprot id: Q1K6M7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nth/MutY family.
messages: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion
messages: Nucleus

367110:NCU06804
gene id: 367110:NCU06804
uniprot id: Q1K8X6
names: Similarity
messages: Belongs to the PheA/TfdB FAD monooxygenase family.

367110:NCU05289
gene id: 367110:NCU05289
uniprot id: Q7S908
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

367110:NCU00361
gene id: 367110:NCU00361
uniprot id: Q7RZK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SYF2 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

367110:NCU06540
gene id: 367110:NCU06540
uniprot id: Q7S9I6
names: Similarity
messages: Belongs to the PAT1 family.

367110:NCU03838
gene id: 367110:NCU03838
uniprot id: Q7S743
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPT4 family.
messages: Component of the spt4-spt5 complex. Interacts with RNA polymerase II (By similarity).
messages: Nucleus
messages: The spt4-spt5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).
messages: centromere

367110:NCU04645
gene id: 367110:NCU04645
uniprot id: Q1K6G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM24 family.
messages: Mitochondrion

367110:NCU10337
gene id: 367110:NCU10337
uniprot id: Q7S7G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

367110:NCU03505
gene id: 367110:NCU03505
uniprot id: Q7RW47
names: Similarity
messages: Belongs to the JHDM3 histone demethylase family.

367110:NCU09818
gene id: 367110:NCU09818
uniprot id: Q7SCP9
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06308
gene id: 367110:NCU06308
uniprot id: P38671
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phage and mitochondrial RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Mitochondrion

367110:NCU01086
gene id: 367110:NCU01086
uniprot id: Q7S811
names: Similarity
messages: Belongs to the cytochrome P450 family.

367110:NCU02998
gene id: 367110:NCU02998
uniprot id: V5IQA5
uniprot id: V5IRG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

367110:NCU04343
gene id: 367110:NCU04343
uniprot id: Q7RX33
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Binds 1 Fe(2+) ion per monomer.
messages: Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine and subsequent conjugation with cysteine and oxygen to form hercynylcysteine sulfoxide, the first two steps in the biosynthesis pathway of ergothioneine (PubMed:22209968). Ergothioneine is an antioxidant against peroxide in conidia and contributes to conidial longevity (PubMed:22209968, PubMed:25446508).
messages: Cytoplasm
messages: Does not produce ergothioneine in either conidia nor mycelia.
messages: In the C-terminal section; belongs to the EgtB family.
messages: In the N-terminal section; belongs to the methyltransferase superfamily. EgtD family.
messages: Nucleus

367110:NCU04009
gene id: 367110:NCU04009
uniprot id: Q1K617
names: Subcellular Location Annotation
messages: Cytoplasm

367110:NCU07471
gene id: 367110:NCU07471
uniprot id: Q7SCP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the F-actin-capping protein beta subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).
messages: Heterodimer of an alpha and a beta subunit.
messages: Nucleus
messages: cytoskeleton

367110:NCU01789
gene id: 367110:NCU01789
uniprot id: V5IN79
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU03860
gene id: 367110:NCU03860
uniprot id: Q7RW74
names: Function
names: Similarity
messages: Belongs to the endosulfine family.
messages: Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.

367110:NCU03333
gene id: 367110:NCU03333
uniprot id: Q7RXE9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

367110:NCU03325
gene id: 367110:NCU03325
uniprot id: Q7SEL9
names: Caution
names: Function
names: Similarity
messages: Belongs to the PLPL family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probable lipid hydrolase.

367110:NCU03124
gene id: 367110:NCU03124
uniprot id: Q8TG13
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.
messages: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (By similarity). Phosphorylates the frq clock protein thus regulating the circadian clock (PubMed:11959847).
messages: Tetramer composed of two alpha chains, one beta chain and one beta' chain.

367110:NCU00396
gene id: 367110:NCU00396
uniprot id: Q7RYR4
uniprot id: U9W8L1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the RSE1 family.
messages: Involved in pre-mRNA splicing and cell cycle control.
messages: Nucleus

367110:NCU06741
gene id: 367110:NCU06741
uniprot id: Q1K8U2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 6B family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 11 subunits. The complex is composed of a catalytic core of 3 subunits Cox1, Cox2 and Cox3, encoded in the mitochondrial DNA, and 8 supernumerary subunits Cox4, Cox5a/Cox5, Cox6, Cox7, Cox8, Cox7a/Cox9, Cox6b/Cox12 and Cox6a/Cox13, which are encoded in the nuclear genome (PubMed:31316820). The complex exists as a monomer or a dimer and forms respiratory supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in various different assemblies (supercomplexes I(1)IV(1), I(1)III(3)IV(2), III(2)IV(1) and III(2)IV(2) as well as larger supercomplexes of compositions like I(1)III(2)IV(5-6)) (PubMed:17873079).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of Cox2 and heme A of Cox1 to the active site in Cox1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane
messages: The Cx9C/Cx10C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system and the subsequent transfer of disulfide bonds by dithiol/disulfide exchange reactions to the newly imported protein.

367110:NCU06682
gene id: 367110:NCU06682
uniprot id: Q7S7N1
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

367110:NCU05028
gene id: 367110:NCU05028
uniprot id: Q7RX60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

367110:NCU03122
gene id: 367110:NCU03122
uniprot id: V5IPG6
names: Similarity
messages: Belongs to the beclin family.

367110:NCU04578
gene id: 367110:NCU04578
uniprot id: Q1K659
names: Similarity
messages: Belongs to the peptidase S14 family.

367110:NCU03150
gene id: 367110:NCU03150
uniprot id: Q7SDU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Component of the large ribosomal subunit (LSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

367110:NCU10010
gene id: 367110:NCU10010
uniprot id: Q7S0J6
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06924
gene id: 367110:NCU06924
uniprot id: Q7S3C9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
messages: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.
messages: Mitochondrion outer membrane

367110:NCU06468
gene id: 367110:NCU06468
uniprot id: Q7RYV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the midasin family.
messages: Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.
messages: nucleolus
messages: nucleoplasm

367110:NCU01114
gene id: 367110:NCU01114
uniprot id: Q1K770
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

367110:NCU00114
gene id: 367110:NCU00114
uniprot id: Q7RYL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Mitochondrion

367110:NCU08904
gene id: 367110:NCU08904
uniprot id: Q7S0A4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOB1 family.
messages: Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm.
messages: nucleolus

367110:NCU06733
gene id: 367110:NCU06733
uniprot id: V5IMM6
uniprot id: V5IPE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

367110:NCU09026
gene id: 367110:NCU09026
uniprot id: Q7S2U9
names: Similarity
messages: Belongs to the tannase family.

367110:NCU09270
gene id: 367110:NCU09270
uniprot id: Q7S1N7
names: Similarity
messages: Belongs to the TCP11 family.

367110:NCU08877
gene id: 367110:NCU08877
uniprot id: Q7S790
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

367110:NCU00777
gene id: 367110:NCU00777
uniprot id: Q7SFV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.
messages: Cytoplasm
messages: Nucleus

367110:NCU06361
gene id: 367110:NCU06361
uniprot id: V5IMI6
uniprot id: V5ING7
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU00937
gene id: 367110:NCU00937
uniprot id: Q7SFB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 79 family.
messages: Beta-glucuronidase that hydrolyzes beta-glucuronosyl and 4-O-methyl-beta-glucuronosyl residues of arabinogalactan-protein. Hydrolyzed heparan sulfate only very weakly. Has no activity on xylan from birchwood. Able to catalyze the transglycosylation of glucuronic acid (GlcA) residues from p-nitrophenyl-beta-glucuronic acid (PNP beta-GlcA) to various monosaccharide acceptors such as glucose, galactose and xylose.
messages: Secreted

367110:NCU06095
gene id: 367110:NCU06095
uniprot id: V5IKI9
uniprot id: V5IME8
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU07683
gene id: 367110:NCU07683
uniprot id: Q7S9L9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

367110:NCU06285
gene id: 367110:NCU06285
uniprot id: Q7SAE5
names: Similarity
messages: Belongs to the peptidase M28 family. M28B subfamily.

367110:NCU01235
gene id: 367110:NCU01235
uniprot id: Q1K820
names: Similarity
messages: Belongs to the SF3A3 family.

367110:NCU03814
gene id: 367110:NCU03814
uniprot id: P15181
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Mitochondrion matrix

367110:NCU02294
gene id: 367110:NCU02294
uniprot id: Q7S576
names: Subcellular Location Annotation
messages: Membrane

367110:NCU00379
gene id: 367110:NCU00379
uniprot id: Q7RYT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC12 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER.

367110:NCU07384
gene id: 367110:NCU07384
uniprot id: Q7S2H8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.
messages: Mitochondrion inner membrane

367110:NCU09255
gene id: 367110:NCU09255
uniprot id: Q7SF55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF3 subfamily.
messages: Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.

367110:NCU07173
gene id: 367110:NCU07173
uniprot id: Q1K5W4
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

367110:NCU04374
gene id: 367110:NCU04374
uniprot id: Q7RWQ6
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03635
gene id: 367110:NCU03635
uniprot id: Q9C2B9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL38 family.
messages: Component of the large ribosomal subunit (LSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

367110:NCU01206
gene id: 367110:NCU01206
uniprot id: Q8X0S9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.
messages: Chromosome
messages: Component of the COMPASS (Set1C) complex.
messages: Nucleus

367110:NCU05803
gene id: 367110:NCU05803
uniprot id: Q7S5P0
names: Subcellular Location Annotation
messages: cytoskeleton

367110:NCU04773
gene id: 367110:NCU04773
uniprot id: Q7S636
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU07854
gene id: 367110:NCU07854
uniprot id: Q7SBV4
names: Similarity
messages: Belongs to the RICTOR family.

367110:NCU07571
gene id: 367110:NCU07571
uniprot id: U9W5A0
names: Subcellular Location Annotation
messages: Nucleus
messages: kinetochore

367110:NCU02977
gene id: 367110:NCU02977
uniprot id: F5HFU8
names: Subcellular Location Annotation
messages: Membrane

367110:NCU01919
gene id: 367110:NCU01919
uniprot id: Q7SH87
names: Similarity
messages: Belongs to the peptidase C19 family.

367110:NCU10314
gene id: 367110:NCU10314
uniprot id: A7UWB7
names: Subcellular Location Annotation
messages: Membrane

367110:NCU11375
gene id: 367110:NCU11375
uniprot id: A7UX52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM234 family.
messages: Membrane

367110:NCU10893
gene id: 367110:NCU10893
uniprot id: Q6MVL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dUTPase family.
messages: Homotrimer.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

367110:NCU02623
gene id: 367110:NCU02623
uniprot id: Q7SFZ7
names: Function
names: Similarity
names: Subunit
messages: Associates with the respiratory chain complex III/complex IV supercomplex.
messages: Belongs to the RCF1 family.
messages: Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.

367110:NCU05966
gene id: 367110:NCU05966
uniprot id: Q7S1V5
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU02545
gene id: 367110:NCU02545
uniprot id: Q7SHR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS26 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Mitochondrion

367110:NCU02137
gene id: 367110:NCU02137
uniprot id: Q7SE39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGC family.
messages: Membrane

367110:NCU06463
gene id: 367110:NCU06463
uniprot id: Q7RYV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mis12 family.
messages: kinetochore

367110:NCU00056
gene id: 367110:NCU00056
uniprot id: Q7RVN4
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

367110:NCU04171
gene id: 367110:NCU04171
uniprot id: Q1K6P0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins. Unlike bacterial L5, uL5m does not bind zinc.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU03610
gene id: 367110:NCU03610
uniprot id: Q1K7R7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

367110:NCU06714
gene id: 367110:NCU06714
uniprot id: Q1K6X7
names: Similarity
messages: In the C-terminal section; belongs to the anthranilate synthase component I family.

367110:NCU00105
gene id: 367110:NCU00105
uniprot id: Q7RYM3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NIP7 family.
messages: Interacts with pre-ribosome complex.
messages: Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.
messages: nucleolus

367110:NCU09706
gene id: 367110:NCU09706
uniprot id: Q7S2S0
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.

367110:NCU10021
gene id: 367110:NCU10021
uniprot id: Q7S0I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU06710
gene id: 367110:NCU06710
uniprot id: Q1K6Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLPTM1 family.
messages: Membrane

367110:NCU02991
gene id: 367110:NCU02991
uniprot id: Q1K942
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU05717
gene id: 367110:NCU05717
uniprot id: Q7SB95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Mitochondrion

367110:NCU05245
gene id: 367110:NCU05245
uniprot id: Q7S8U0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.
messages: Membrane
messages: Peroxisome membrane

367110:NCU00300
gene id: 367110:NCU00300
uniprot id: Q7RZR4
names: Subcellular Location Annotation
messages: Membrane

367110:NCU05564
gene id: 367110:NCU05564
uniprot id: V5IKN8
uniprot id: V5IKX2
names: Subcellular Location Annotation
messages: Peroxisome membrane

367110:NCU09894
gene id: 367110:NCU09894
uniprot id: Q7S205
names: Similarity
messages: Belongs to the CBF/MAK21 family.

367110:NCU08336
gene id: 367110:NCU08336
uniprot id: A7UWT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

367110:NCU00260
gene id: 367110:NCU00260
uniprot id: Q7RZV3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

367110:NCU08731
gene id: 367110:NCU08731
uniprot id: V5IPP3
names: Similarity
messages: Belongs to the APC10 family.

367110:NCU00040
gene id: 367110:NCU00040
uniprot id: Q7RWT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit A family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

367110:NCU09564
gene id: 367110:NCU09564
uniprot id: P15710
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Cell membrane
messages: High-affinity transporter for external inorganic phosphate. Acts probably as a sodium-phosphate symporter. Component of the high affinity phosphate transport system II (ptsII) necessary for scavenging phosphorus from the environment under conditions of limiting phosphorus.
messages: Impairs growth at low phosphate conditions when pho-5 is also absent. Prevents vanadate uptake.
messages: Phosphate transport activity is competitively inhibited by vanadate and arsenate.
messages: Transcription is controlled by the phosphorus-acquisition regulatory system.

367110:NCU03306
gene id: 367110:NCU03306
uniprot id: Q7SEN8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: cytoskeleton

367110:NCU03606
gene id: 367110:NCU03606
uniprot id: Q1K7R9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.
messages: Belongs to the replication factor A protein 1 family.
messages: Component of the heterotrimeric canonical replication protein A complex (RPA).
messages: Nucleus

367110:NCU01296
gene id: 367110:NCU01296
uniprot id: V5ILM9
uniprot id: V5IP65
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
messages: Membrane

367110:NCU06497
gene id: 367110:NCU06497
uniprot id: Q7RYH8
names: Function
names: Similarity
messages: Belongs to the CDC123 family.
messages: Regulates the cell cycle in a nutrient dependent manner.

367110:NCU01625
gene id: 367110:NCU01625
uniprot id: Q7RXF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II.
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

367110:NCU06174
gene id: 367110:NCU06174
uniprot id: Q7SAR5
names: Similarity
messages: Belongs to the ATG101 family.

367110:NCU09888
gene id: 367110:NCU09888
uniprot id: Q7S226
names: Similarity
messages: Belongs to the glycosyltransferase 34 family.

367110:NCU01605
gene id: 367110:NCU01605
uniprot id: Q9P601
names: Similarity
messages: Belongs to the MOB1/phocein family.

367110:NCU07879
gene id: 367110:NCU07879
uniprot id: Q7SB14
names: Subcellular Location Annotation
messages: Membrane

367110:NCU09449
gene id: 367110:NCU09449
uniprot id: Q7S0G4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fungal TPase family.
messages: First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.
messages: Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.
messages: Nucleus

367110:NCU07564
gene id: 367110:NCU07564
uniprot id: Q7S1Y9
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03909
gene id: 367110:NCU03909
uniprot id: F5HDH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

367110:NCU02108
gene id: 367110:NCU02108
uniprot id: Q7SDM5
names: Similarity
messages: Belongs to the BolA/IbaG family.

367110:NCU08045
gene id: 367110:NCU08045
uniprot id: Q7SAJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.
messages: Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).
messages: Endoplasmic reticulum membrane

367110:NCU02474
gene id: 367110:NCU02474
uniprot id: Q7SG90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom5 family.
messages: Membrane
messages: Mitochondrion outer membrane

367110:NCU00338
gene id: 367110:NCU00338
uniprot id: Q7RZM6
names: Similarity
messages: Belongs to the peptidase A1 family.

367110:NCU02706
gene id: 367110:NCU02706
uniprot id: Q7SH23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR1 family.
messages: Component of several multiprotein Golgi SNARE complexes.
messages: Golgi apparatus membrane
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.
messages: Membrane

367110:NCU08364
gene id: 367110:NCU08364
uniprot id: Q7SGQ1
names: Similarity
messages: Belongs to the sulfatase family.

367110:NCU06750
gene id: 367110:NCU06750
uniprot id: Q7SCC7
names: Similarity
messages: Belongs to the CCDC25 family.

367110:NCU06333
gene id: 367110:NCU06333
uniprot id: Q7SA98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU11159
gene id: 367110:NCU11159
uniprot id: Q873B7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC25 family.
messages: Component of the NDC80 complex, which consists of kpr-1/ndc80, kpr-2/nuf2, kpr-3/spc24 and kpr-4/spc25.
messages: Nucleus
messages: kinetochore

367110:NCU04651
gene id: 367110:NCU04651
uniprot id: Q1K6G4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.

367110:NCU07166
gene id: 367110:NCU07166
uniprot id: Q1K5X0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA43 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

367110:NCU09332
gene id: 367110:NCU09332
uniprot id: Q7SD53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

367110:NCU06048
gene id: 367110:NCU06048
uniprot id: V5IMG5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS30 family.

367110:NCU09692
gene id: 367110:NCU09692
uniprot id: Q1K6J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

367110:NCU03278
gene id: 367110:NCU03278
uniprot id: Q7SDX7
names: Subcellular Location Annotation
messages: Membrane

367110:NCU07261
gene id: 367110:NCU07261
uniprot id: Q7S954
names: Function
messages: Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.

367110:NCU08054
gene id: 367110:NCU08054
uniprot id: Q7SGM9
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

367110:NCU00348
gene id: 367110:NCU00348
uniprot id: Q7RZL7
names: Similarity
messages: Belongs to the PHF5 family.

367110:NCU01364
gene id: 367110:NCU01364
uniprot id: Q1K6N3
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

367110:NCU07609
gene id: 367110:NCU07609
uniprot id: Q7SB45
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03033
gene id: 367110:NCU03033
uniprot id: Q7SGY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Heterotrimer.
messages: Nucleus

367110:NCU04885
gene id: 367110:NCU04885
uniprot id: Q7S081
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

367110:NCU03217
gene id: 367110:NCU03217
uniprot id: Q7SGV2
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane

367110:NCU04788
gene id: 367110:NCU04788
uniprot id: Q7S6P7
names: Similarity
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.

367110:NCU05627
gene id: 367110:NCU05627
uniprot id: Q7S5X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU02755
gene id: 367110:NCU02755
uniprot id: Q7SCX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

367110:NCU02653
gene id: 367110:NCU02653
uniprot id: Q7SH75
names: Subcellular Location Annotation
messages: Membrane

367110:NCU00579
gene id: 367110:NCU00579
uniprot id: V5IQ74
uniprot id: V5IQK7
names: Similarity
messages: Belongs to the OSBP family.

367110:NCU02221
gene id: 367110:NCU02221
uniprot id: Q7S4H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex SPC34 family.
messages: Nucleus
messages: kinetochore
messages: spindle

367110:NCU10009
gene id: 367110:NCU10009
uniprot id: Q7S0J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
messages: Membrane

367110:NCU04136
gene id: 367110:NCU04136
uniprot id: Q1K7L8
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

367110:NCU03653
gene id: 367110:NCU03653
uniprot id: Q1K6Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS41 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Mitochondrion

367110:NCU02543
gene id: 367110:NCU02543
uniprot id: Q7SHS1
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

367110:NCU03007
gene id: 367110:NCU03007
uniprot id: Q7RUX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SLT11 family.
messages: Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA (By similarity).
messages: Nucleus

367110:NCU06485
gene id: 367110:NCU06485
uniprot id: Q7RYI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: nucleolus

367110:NCU03937
gene id: 367110:NCU03937
uniprot id: Q7RZC0
names: Similarity
messages: Belongs to the sorting nexin family.

367110:NCU11353
gene id: 367110:NCU11353
uniprot id: A7UWY8
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.

367110:NCU01948
gene id: 367110:NCU01948
uniprot id: Q7SDY8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

367110:NCU10381
gene id: 367110:NCU10381
uniprot id: A7UW29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

367110:NCU06342
gene id: 367110:NCU06342
uniprot id: Q7S9W4
names: Similarity
messages: Belongs to the phospholipase D family.

367110:NCU02497
gene id: 367110:NCU02497
uniprot id: Q7SG67
names: Similarity
messages: Belongs to the MYBBP1A family.

367110:NCU04310
gene id: 367110:NCU04310
uniprot id: Q7S7L6
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06450
gene id: 367110:NCU06450
uniprot id: Q7RYW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU03302
gene id: 367110:NCU03302
uniprot id: Q7SEP1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

367110:NCU06700
gene id: 367110:NCU06700
uniprot id: Q1K738
names: Similarity
messages: Belongs to the polyketide transferase af380 family.

367110:NCU01598
gene id: 367110:NCU01598
uniprot id: F5HCY5
names: Similarity
messages: Belongs to the asaB hydroxylase/desaturase family.

367110:NCU06033
gene id: 367110:NCU06033
uniprot id: Q7S4F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGS family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU06587
gene id: 367110:NCU06587
uniprot id: Q7S8M7
names: Similarity
messages: Belongs to the MTFP1 family.

367110:NCU04142
gene id: 367110:NCU04142
uniprot id: Q1K7L5
names: Similarity
messages: Belongs to the heat shock protein 90 family.

367110:NCU03611
gene id: 367110:NCU03611
uniprot id: P29070
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chitin synthase family. Class III subfamily.
messages: Cell membrane
messages: Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.

367110:NCU02228
gene id: 367110:NCU02228
uniprot id: Q7S4G5
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

367110:NCU04460
gene id: 367110:NCU04460
uniprot id: Q7RYE7
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 zinc ion per subunit. Zinc binding seems to play a structural role.
messages: Homodimer.

367110:NCU02254
gene id: 367110:NCU02254
uniprot id: V5IKG7
uniprot id: V5ILN8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCC family.
messages: Cytoplasm
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.

367110:NCU03459
gene id: 367110:NCU03459
uniprot id: Q1K4U2
names: Subcellular Location Annotation
messages: Membrane

367110:NCU01365
gene id: 367110:NCU01365
uniprot id: Q1K6N2
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.

367110:NCU09093
gene id: 367110:NCU09093
uniprot id: Q7SFQ7
names: Similarity
messages: Belongs to the DEAD box helicase family.

367110:NCU03387
gene id: 367110:NCU03387
uniprot id: Q1K5G2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

367110:NCU08457
gene id: 367110:NCU08457
uniprot id: Q04571
names: Developmental Stage
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Accumulates during conidiation but not during germination.
messages: Belongs to the fungal hydrophobin family.
messages: Contributes to surface hydrophobicity, which is important for processes such as association of hyphae in reproductive structures, dispersal of aerial spores and adhesion of pathogens to host structures. Important for the formation of hydrophobic rodlet layers of asexually-produced spores.
messages: Expression is controlled by blue light and by a circadian clock. Also induced by glucose, nitrogen and carbon starvation.
messages: cell wall

367110:NCU06526
gene id: 367110:NCU06526
uniprot id: Q7S8A1
names: Similarity
messages: Belongs to the cytochrome P450 family.

367110:NCU04175
gene id: 367110:NCU04175
uniprot id: Q1K7F0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU09120
gene id: 367110:NCU09120
uniprot id: Q7S2M8
names: Similarity
messages: Belongs to the flavin monoamine oxidase family.

367110:NCU01758
gene id: 367110:NCU01758
uniprot id: F5HCB9
names: Similarity
messages: Belongs to the SELO family.

367110:NCU08377
gene id: 367110:NCU08377
uniprot id: Q01631
uniprot id: V5IRM6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the adenylyl cyclase class-3 family.
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.

367110:NCU05778
gene id: 367110:NCU05778
uniprot id: Q7S5R5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NifU family.
messages: Mitochondrion matrix
messages: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.

367110:NCU09678
gene id: 367110:NCU09678
uniprot id: Q1K6Q7
names: Subcellular Location Annotation
messages: Membrane

367110:NCU09673
gene id: 367110:NCU09673
uniprot id: Q1K6R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: coated pit

367110:NCU08828
gene id: 367110:NCU08828
uniprot id: Q01373
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Contains two SDR domains.
messages: Monomer.
messages: Peroxisome
messages: Second trifunctional enzyme acting on the beta-oxidation pathway for fatty acids, possessing hydratase-dehydrogenase-epimerase activities. Converts trans-2-enoyl-CoA via D-3-hydroxyacyl-CoA to 3-ketoacyl-CoA.

367110:NCU02571
gene id: 367110:NCU02571
uniprot id: Q7SHP4
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

367110:NCU03725
gene id: 367110:NCU03725
uniprot id: Q9C2N1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Transcription factor that acts as a positive regulator of nonrepressible acid phosphatase activity. Is a major regulator of responses to nitrogen and carbon starvation and is essential for the expression of genes involved in vegetative incompatibility (like pin-c, het-6, and tol). Vegetative incompatibility is a non-self-recognition system ubiquitous in filamentous fungi which results in programmed cell death.

367110:NCU10106
gene id: 367110:NCU10106
uniprot id: A7UWK5
names: Similarity
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Homodimer.

367110:NCU09265
gene id: 367110:NCU09265
uniprot id: Q7SF45
names: Similarity
messages: Belongs to the calreticulin family.

367110:NCU04817
gene id: 367110:NCU04817
uniprot id: Q7S6L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

367110:NCU01083
gene id: 367110:NCU01083
uniprot id: Q1K889
names: Similarity
messages: Belongs to the eukaryotic AdoMetDC family.

367110:NCU00317
gene id: 367110:NCU00317
uniprot id: Q7RZP7
uniprot id: U9WGW4
names: Function
names: Similarity
messages: Belongs to the peptidase C2 family. PalB/RIM13 subfamily.
messages: Required for the proteolytic cleavage of the transcription factor pacc-1 in response to alkaline ambient pH.

367110:NCU01965
gene id: 367110:NCU01965
uniprot id: P28350
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: May have a second function in addition to protein synthesis.
messages: Mitochondrion

367110:NCU04188
gene id: 367110:NCU04188
uniprot id: Q1K7E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

367110:NCU06498
gene id: 367110:NCU06498
uniprot id: Q7RYH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the NTC complex (or PRP19-associated complex). The NTC complex associates with the spliceosome after the release of the U1 and U4 snRNAs and forms the CWC spliceosome subcomplex reminiscent of a late-stage spliceosome.
messages: Belongs to the CWC21 family.
messages: Cytoplasm
messages: Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity).
messages: Nucleus

367110:NCU07153
gene id: 367110:NCU07153
uniprot id: Q1K5Y1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.
messages: Secreted

367110:NCU01905
gene id: 367110:NCU01905
uniprot id: Q7SHA1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

367110:NCU06618
gene id: 367110:NCU06618
uniprot id: Q7S9P7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

367110:NCU04783
gene id: 367110:NCU04783
uniprot id: Q7S626
names: Similarity
messages: Belongs to the epsin family.

367110:NCU16396
gene id: 367110:NCU16396
uniprot id: V5IQT0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
messages: Mitochondrion inner membrane

367110:NCU06850
gene id: 367110:NCU06850
uniprot id: Q1K8K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.

367110:NCU02808
gene id: 367110:NCU02808
uniprot id: Q7SEK6
names: Similarity
messages: Belongs to the nucleoporin NSP1/NUP62 family.

367110:NCU00100
gene id: 367110:NCU00100
uniprot id: Q7RYM8
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU04306
gene id: 367110:NCU04306
uniprot id: Q7S7L7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm

367110:NCU02781
gene id: 367110:NCU02781
uniprot id: Q7SE13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: actin patch

367110:NCU01535
gene id: 367110:NCU01535
uniprot id: Q7RY61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-14 family.
messages: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
messages: Peroxisome membrane

367110:NCU09311
gene id: 367110:NCU09311
uniprot id: F5HAU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

367110:NCU03652
gene id: 367110:NCU03652
uniprot id: Q1K6Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

367110:NCU02433
gene id: 367110:NCU02433
uniprot id: Q7S3X7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine. ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy. In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components. ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS.
messages: Cytoplasm
messages: Nucleus
messages: Preautophagosomal structure

367110:NCU00634
gene id: 367110:NCU00634
uniprot id: Q7SI18
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

367110:NCU07988
gene id: 367110:NCU07988
uniprot id: Q7SAQ2
names: Similarity
messages: Belongs to the AAA ATPase family.

367110:NCU00316
gene id: 367110:NCU00316
uniprot id: Q7RZP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

367110:NCU02797
gene id: 367110:NCU02797
uniprot id: Q7SEL5
names: Function
names: Similarity
messages: Belongs to the UDPGP type 1 family.
messages: Plays a central role as a glucosyl donor in cellular metabolic pathways.

367110:NCU00502
gene id: 367110:NCU00502
uniprot id: Q7SE71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase B chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/atp6 static relative to the rotary elements (By similarity).
messages: Mitochondrion
messages: Mitochondrion inner membrane

367110:NCU03112
gene id: 367110:NCU03112
uniprot id: Q7SFY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: May mediate the reduction of outer membrane cytochrome b5.
messages: Mitochondrion outer membrane

367110:NCU03440
gene id: 367110:NCU03440
uniprot id: Q1K5B2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
messages: Belongs to the adaptor complexes large subunit family.
messages: coated pit

367110:NCU07761
gene id: 367110:NCU07761
uniprot id: Q7S110
names: Similarity
messages: Belongs to the glycosyltransferase 32 family.

367110:NCU03686
gene id: 367110:NCU03686
uniprot id: V5IL43
uniprot id: V5ILD8
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU04540
gene id: 367110:NCU04540
uniprot id: Q7RWG8
names: Similarity
messages: Belongs to the WD repeat MET30/SCONB/SCON-2 family.

367110:NCU00028
gene id: 367110:NCU00028
uniprot id: U9W4Q7
uniprot id: U9WGL1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

367110:NCU07409
gene id: 367110:NCU07409
uniprot id: Q7S0U6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat TRM82 family.
messages: Nucleus
messages: Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

367110:NCU01571
gene id: 367110:NCU01571
uniprot id: Q1K4W9
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.

367110:NCU00468
gene id: 367110:NCU00468
uniprot id: U9W564
uniprot id: U9W8P4
names: Similarity
messages: Belongs to the prephenate/arogenate dehydrogenase family.

367110:NCU08270
gene id: 367110:NCU08270
uniprot id: Q7S8J7
names: Function
names: Induction
names: Similarity
messages: Belongs to the helicase family. Dicer subfamily.
messages: By double-stranded RNA (dsRNA).
messages: Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons. Controls the expression of the non-LTR retrotransposon Tad in the African strain, Adiomopoume.

367110:NCU07893
gene id: 367110:NCU07893
uniprot id: Q7S883
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF5 family.
messages: Nucleus

367110:NCU10225
gene id: 367110:NCU10225
uniprot id: V5IL34
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane

367110:NCU16821
gene id: 367110:NCU16821
uniprot id: V5IP70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

367110:NCU04585
gene id: 367110:NCU04585
uniprot id: Q1K654
names: Similarity
messages: Belongs to the sorting nexin family.

367110:NCU03763
gene id: 367110:NCU03763
uniprot id: Q1K7B3
names: Similarity
messages: Belongs to the DNA polymerase delta/II small subunit family.

367110:NCU07509
gene id: 367110:NCU07509
uniprot id: Q7SG33
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

367110:NCU09216
gene id: 367110:NCU09216
uniprot id: Q1K6C9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

367110:NCU02921
gene id: 367110:NCU02921
uniprot id: Q7SHI3
names: Caution
names: Function
names: Induction
names: Similarity
messages: A recent genetics report associated srdA and its cluster with the biosynthesis of furanocoumarin neurosporin A, a metabolite produced by N.crassa for chemoresistance against predation by arthropod fungivores (PubMed:28485098). However, based on the gene cluster organization and predicted gene functions, this cluster is unlikely to be involved in neurosporin A biosynthesis, but instead produces compounds similar to pyriculol (PubMed:30908040).
messages: Belongs to the virC family.
messages: Expression is up-regulated during sexual development (PubMed:19277664). Expression is also up-regulated during confrontation with the arthropod fungivore Drosophila melanogaster (PubMed:28485098).
messages: Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of sordarial, a salicylic aldehyde structurally related to the phytotoxin pyriculol (PubMed:19277664, PubMed:28485098, PubMed:30908040). The most interesting aspect of this pathway is formation of an aromatic product from the highly reducing polyketide synthase srdA (PubMed:30908040). SrdA synthesizes a reduced polyketide chain from one molecule of acetyl-CoA and five molecules of malonyl-CoA (PubMed:30908040). The polyketide chain is then reductively released as an aldehyde (PubMed:30908040). The oxidoreductases srdC, srdD and srdE then oxidize one of the hydroxy groups to facilitate the intramolecular aldol condensation, followed by dehydration to yield a salicylic aldehyde (PubMed:30908040). This aldehyde can undergo facile reduction by endogenous reductases to yield the alcohol 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene (PubMed:30908040). The flavin-dependent srdI counteract against the propensity of the aldehydes to be reduced under physiological conditions and is responsible for reoxidizing 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene back to the salicylic aldehyde (PubMed:30908040). This salicylic aldehyde is then selectively epoxidized by the cupin-domain-containing oxidoreductase srdB to yield the epoxide, which can be hydrolyzed stereoselectively by the hydrolase srdG to give the final product sordarial (PubMed:30908040).

367110:NCU02478
gene id: 367110:NCU02478
uniprot id: Q7SG86
names: Similarity
messages: Belongs to the glycosyltransferase group 1 family.

367110:NCU09195
gene id: 367110:NCU09195
uniprot id: Q1K6E4
names: Subcellular Location Annotation
messages: Membrane

367110:NCU05776
gene id: 367110:NCU05776
uniprot id: V5IKP7
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03269
gene id: 367110:NCU03269
uniprot id: Q7SEF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex (By similarity).

367110:NCU07885
gene id: 367110:NCU07885
uniprot id: Q7SB08
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU03024
gene id: 367110:NCU03024
uniprot id: Q7SGZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS53 family.
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

367110:NCU00793
gene id: 367110:NCU00793
uniprot id: Q7SFT8
names: Similarity
messages: In the C-terminal section; belongs to the trehalose phosphatase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 20 family.

367110:NCU03084
gene id: 367110:NCU03084
uniprot id: V5IQM2
names: Similarity
messages: Belongs to the IUNH family.

367110:NCU03597
gene id: 367110:NCU03597
uniprot id: Q1K7S4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
messages: Belongs to the DNA polymerase alpha subunit B family.
messages: Nucleus

367110:NCU00950
gene id: 367110:NCU00950
uniprot id: Q7SGH2
names: Function
names: Similarity
messages: Belongs to the Dus family. Dus3 subfamily.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs (By similarity). Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.

367110:NCU06769
gene id: 367110:NCU06769
uniprot id: Q8X082
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the activator 1 small subunits family.
messages: Heteropentamer of subunits rfc1, rfc2, rfc3, rfc4 and rfc5 that forms a complex with PCNA in the presence of ATP.
messages: Nucleus
messages: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.

367110:NCU09767
gene id: 367110:NCU09767
uniprot id: Q7S194
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06414
gene id: 367110:NCU06414
uniprot id: Q7RWE4
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

367110:NCU07457
gene id: 367110:NCU07457
uniprot id: Q7SD49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPF family.
messages: Interacts with eme-1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).
messages: Interacts with eme-1.
messages: Nucleus

367110:NCU06199
gene id: 367110:NCU06199
uniprot id: Q7SBC4
names: Function
names: Subcellular Location Annotation
messages: RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.
messages: nucleolus

367110:NCU03273
gene id: 367110:NCU03273
uniprot id: Q7SEF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NFX1 family.
messages: Nucleus

367110:NCU05454
gene id: 367110:NCU05454
uniprot id: F5HHQ6
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

367110:NCU05939
gene id: 367110:NCU05939
uniprot id: Q7S2D9
names: Similarity
messages: Belongs to the WD repeat MET30/SCONB/SCON-2 family.

367110:NCU01870
gene id: 367110:NCU01870
uniprot id: Q7SHD6
names: Similarity
messages: Belongs to the enolase family.

367110:NCU08194
gene id: 367110:NCU08194
uniprot id: Q7S3P3
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06622
gene id: 367110:NCU06622
uniprot id: Q7S9P4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

367110:NCU05514
gene id: 367110:NCU05514
uniprot id: Q7S6S5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

367110:NCU09900
gene id: 367110:NCU09900
uniprot id: Q7S1Z9
names: Similarity
messages: Belongs to the VPS37 family.

367110:NCU06088
gene id: 367110:NCU06088
uniprot id: Q7S484
names: Similarity
messages: Belongs to the TMA16 family.

367110:NCU03229
gene id: 367110:NCU03229
uniprot id: Q1K930
names: Similarity
messages: Belongs to the Tim44 family.

367110:NCU03693
gene id: 367110:NCU03693
uniprot id: Q1K801
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU02333
gene id: 367110:NCU02333
uniprot id: P33280
uniprot id: V5IL23
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Homohexamer.

367110:NCU07824
gene id: 367110:NCU07824
uniprot id: Q7SBE0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MDM10 family.
messages: Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of mmm-1, mdm10, mdm12 and mdm34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex.
messages: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. mdm10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the tom40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of tom40 with the receptor tom22 and small TOM proteins. Can associate with the SAM(core) complex as well as the mdm12-mmm-1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the tom40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.
messages: Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.
messages: Mitochondrion outer membrane

367110:NCU03239
gene id: 367110:NCU03239
uniprot id: Q7SGT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC5 family.
messages: Nucleus

367110:NCU00709
gene id: 367110:NCU00709
uniprot id: Q7SET7
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

367110:NCU07562
gene id: 367110:NCU07562
uniprot id: Q7S1Z1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

367110:NCU06322
gene id: 367110:NCU06322
uniprot id: Q7SAA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS2/PSF2 family.
messages: Component of the GINS complex which is a heterotetramer of div-26/sld5, drc-1/psf1, drc-2/psf2 and drc-3/psf3.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity).

367110:NCU08852
gene id: 367110:NCU08852
uniprot id: Q7S7M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARTD/PARP family.
messages: Nucleus

367110:NCU01447
gene id: 367110:NCU01447
uniprot id: Q1K4R2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

367110:NCU01547
gene id: 367110:NCU01547
uniprot id: Q8WZY4
names: Function
names: Similarity
messages: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the peptidase M67A family.

367110:NCU00461
gene id: 367110:NCU00461
uniprot id: P00365
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homotetramer.

367110:NCU00210
gene id: 367110:NCU00210
uniprot id: Q7RXL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM NCBP2 family.
messages: Nucleus

367110:NCU00444
gene id: 367110:NCU00444
uniprot id: Q7RXR5
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU06976
gene id: 367110:NCU06976
uniprot id: P45443
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dynein heavy chain family.
messages: Consists of at least two heavy chains and a number of intermediate and light chains.
messages: Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required to maintain uniform nuclear distribution in hyphae.
messages: Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.
messages: cytoskeleton

367110:NCU03989
gene id: 367110:NCU03989
uniprot id: Q7RXJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

367110:NCU06958
gene id: 367110:NCU06958
uniprot id: Q7SAJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS21 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Mitochondrion

367110:NCU04762
gene id: 367110:NCU04762
uniprot id: Q7S691
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU02534
gene id: 367110:NCU02534
uniprot id: P22142
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Complex I is composed of about 40 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Mitochondrion inner membrane

367110:NCU00263
gene id: 367110:NCU00263
uniprot id: Q7RZV0
names: Similarity
messages: Belongs to the peptidase S8 family.

367110:NCU00755
gene id: 367110:NCU00755
uniprot id: Q7SDR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

367110:NCU01370
gene id: 367110:NCU01370
uniprot id: Q1K711
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC2 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Component of the origin recognition complex (ORC).
messages: Nucleus

367110:NCU06918
gene id: 367110:NCU06918
uniprot id: Q7S3D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

367110:NCU07999
gene id: 367110:NCU07999
uniprot id: Q7SAP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (By similarity).

367110:NCU01680
gene id: 367110:NCU01680
uniprot id: P07038
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.
messages: Cell membrane
messages: The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.

367110:NCU06232
gene id: 367110:NCU06232
uniprot id: P34738
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

367110:NCU03961
gene id: 367110:NCU03961
uniprot id: Q7RZA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: nucleolus

367110:NCU02603
gene id: 367110:NCU02603
uniprot id: Q7SG17
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

367110:NCU08703
gene id: 367110:NCU08703
uniprot id: Q1K8W4
names: Similarity
messages: Belongs to the PPase family.

367110:NCU07899
gene id: 367110:NCU07899
uniprot id: Q7SA18
names: Similarity
messages: Belongs to the CoA-transferase III family.

367110:NCU01784
gene id: 367110:NCU01784
uniprot id: V5IR27
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

367110:NCU01242
gene id: 367110:NCU01242
uniprot id: F5HHN7
names: Similarity
messages: Belongs to the cyclin family.

367110:NCU10388
gene id: 367110:NCU10388
uniprot id: Q6MWS8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

367110:NCU02984
gene id: 367110:NCU02984
uniprot id: Q9P3T4
names: Domain
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DENR family.
messages: Cytoplasm
messages: Interacts with the 40S ribosomal subunit.
messages: The SUI1 domain may be involved in RNA binding.

367110:NCU01861
gene id: 367110:NCU01861
uniprot id: Q7SHE5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU06605
gene id: 367110:NCU06605
uniprot id: Q7S9R0
names: Similarity
messages: Belongs to the DDB1 family.

367110:NCU02966
gene id: 367110:NCU02966
uniprot id: Q1K953
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the WD repeat PRL1/PRL2 family.
messages: Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.
messages: Nucleus

367110:NCU07559
gene id: 367110:NCU07559
uniprot id: Q7S1Z4
names: Similarity
messages: Belongs to the CAF1 family.

367110:NCU06201
gene id: 367110:NCU06201
uniprot id: U9W4M3
uniprot id: U9WGI1
names: Similarity
messages: Belongs to the UPF0045 family.

367110:NCU16968
gene id: 367110:NCU16968
uniprot id: V5IL66
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

367110:NCU05301
gene id: 367110:NCU05301
uniprot id: Q7S8Z9
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

367110:NCU06173
gene id: 367110:NCU06173
uniprot id: U9W4L4
uniprot id: U9WGH1
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU03980
gene id: 367110:NCU03980
uniprot id: Q7RXK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

367110:NCU00519
gene id: 367110:NCU00519
uniprot id: Q7SCL8
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

367110:NCU00232
gene id: 367110:NCU00232
uniprot id: Q7RZX9
names: Similarity
messages: Belongs to the RNase Z family.

367110:NCU08145
gene id: 367110:NCU08145
uniprot id: Q7S4A2
names: Function
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase family.
messages: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.

367110:NCU07262
gene id: 367110:NCU07262
uniprot id: Q7S953
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Endoplasmic reticulum membrane
messages: Functions as a zinc transporter.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

367110:NCU02305
gene id: 367110:NCU02305
uniprot id: Q7S565
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Assembly of polyisoprenoid side chains. The polyprenyl synthase of coenzyme Q biosynthesis catalyzes the formation from isopentenyl diphosphate of all trans-polyprenyl pyrophosphates generally ranging in length of between 6 and 10 isoprene units depending on the species (By similarity).
messages: Belongs to the FPP/GGPP synthase family.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Mitochondrion

367110:NCU04602
gene id: 367110:NCU04602
uniprot id: V5ILY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.

367110:NCU05198
gene id: 367110:NCU05198
uniprot id: Q7S9D4
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03219
gene id: 367110:NCU03219
uniprot id: V5IPW5
names: Similarity
messages: Belongs to the peptidase S8 family. Furin subfamily.

367110:NCU07546
gene id: 367110:NCU07546
uniprot id: Q7RVS1
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06546
gene id: 367110:NCU06546
uniprot id: Q7S9I1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHE9 family.
messages: Homooligomer.
messages: Mitochondrion inner membrane
messages: Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed (By similarity).

367110:NCU00091
gene id: 367110:NCU00091
uniprot id: U9W4T4
uniprot id: U9W8A1
names: Similarity
messages: Belongs to the WD repeat mio family.

367110:NCU08514
gene id: 367110:NCU08514
uniprot id: Q7SBX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the cyclophilin-type PPIase family. CWC27 subfamily.
messages: Cytoplasm
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing (By similarity).

367110:NCU06484
gene id: 367110:NCU06484
uniprot id: Q7RYJ0
names: Similarity
messages: Belongs to the AAA ATPase family.

367110:NCU03460
gene id: 367110:NCU03460
uniprot id: Q7RWJ5
names: Similarity
messages: Belongs to the UPP synthase family.

367110:NCU00564
gene id: 367110:NCU00564
uniprot id: Q7SF85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Mitochondrion

367110:NCU06446
gene id: 367110:NCU06446
uniprot id: Q7RYX1
names: Similarity
messages: Belongs to the PAF1 family.

367110:NCU02178
gene id: 367110:NCU02178
uniprot id: Q1K907
names: Similarity
messages: Belongs to the RdRP family.

367110:NCU07716
gene id: 367110:NCU07716
uniprot id: V5IM11
names: Subcellular Location Annotation
messages: Membrane
messages: Vacuole membrane

367110:NCU02657
gene id: 367110:NCU02657
uniprot id: P48466
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.

367110:NCU06246
gene id: 367110:NCU06246
uniprot id: Q7SBR1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in mitochondrial RNA metabolism. Required for maintenance of mitochondrial DNA (By similarity).
messages: Belongs to the DEAD box helicase family. MRH4 subfamily.
messages: Mitochondrion
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

367110:NCU03770
gene id: 367110:NCU03770
uniprot id: Q1K7A8
names: Similarity
messages: Belongs to the glycosyl hydrolase 76 family.

367110:NCU02807
gene id: 367110:NCU02807
uniprot id: V5IRA3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the mitochondrial small ribosomal subunit (mt-SSU). IF(1) coiled-coil forms a helical bundle with the C-terminal extension of uS17m and also binds to mS27 in the mtSSU tail. Since the C-terminal extension of uS17m stabilizing the IF(1) on the mt-SSU is specific to N.crassa, IF(1) binding might also be specific.
messages: Belongs to the ATPase inhibitor family.
messages: Endogenous F(1)F(0)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(0)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(0)-ATP synthase enzyme acts as an ATP hydrolase. Functions through inserting its N-terminal part into the catalytically active F1-ATPase, thereby blocking its rotational movement and subsequently the ATP hydrolase activity.
messages: Mitochondrion
messages: The inhibitory N-terminal region (residues 23-59) is entrapped between the C-terminal domains of the alpha(ADP-bound)-beta(ADP-bound) (atp1-atp2) subunits in one of the 3 catalytic interfaces of F(1)F(0)-ATPase.

367110:NCU00135
gene id: 367110:NCU00135
uniprot id: U9W8C3
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

367110:NCU06216
gene id: 367110:NCU06216
uniprot id: Q7SBA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND3 (condensin subunit 3) family.
messages: Chromosome

367110:NCU03296
gene id: 367110:NCU03296
uniprot id: Q7SDW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP11 family.
messages: Mitochondrion

367110:NCU05419
gene id: 367110:NCU05419
uniprot id: Q1K8J0
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

367110:NCU05347
gene id: 367110:NCU05347
uniprot id: Q873G4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated once deposited into chromatin.
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Z forms a heterodimer with H2B. H2A.Z associates with the vps72/swc2 subunit of the SWR1 chromatin remodeling complex. Interacts also with rpo-9/rpb1/DNA-directed RNA polymerase II largest subunit (By similarity).
messages: Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and spt15/TBP recruitment to the target genes. Involved in chromosome stability (By similarity).

367110:NCU03509
gene id: 367110:NCU03509
uniprot id: Q1K4N1
names: Subcellular Location Annotation
messages: Membrane

367110:NCU07154
gene id: 367110:NCU07154
uniprot id: Q1K5Y0
names: Similarity
messages: Belongs to the yippee family.

367110:NCU06336
gene id: 367110:NCU06336
uniprot id: Q7S9X0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

367110:NCU08389
gene id: 367110:NCU08389
uniprot id: V5IQT8
uniprot id: V5IRM4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

367110:NCU07120
gene id: 367110:NCU07120
uniprot id: Q7S6D2
names: Similarity
messages: Belongs to the OBAP family.

367110:NCU11258
gene id: 367110:NCU11258
uniprot id: A7UWA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I LYR family.
messages: Mitochondrion inner membrane

367110:NCU06880
gene id: 367110:NCU06880
uniprot id: Q7S3H3
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

367110:NCU07529
gene id: 367110:NCU07529
uniprot id: Q7S318
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 22 family.
messages: Nucleus

367110:NCU00029
gene id: 367110:NCU00029
uniprot id: Q7RY76
names: Subcellular Location Annotation
messages: Membrane

367110:NCU04355
gene id: 367110:NCU04355
uniprot id: Q7RW65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family.
messages: Cell membrane
messages: Vacuole membrane

367110:NCU06708
gene id: 367110:NCU06708
uniprot id: Q1K6Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU01023
gene id: 367110:NCU01023
uniprot id: Q1K8C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU01051
gene id: 367110:NCU01051
uniprot id: Q1K8B5
names: Similarity
messages: Belongs to the ustYa family.

367110:NCU03402
gene id: 367110:NCU03402
uniprot id: Q7RY09
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03543
gene id: 367110:NCU03543
uniprot id: Q1K5D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG27 family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane

367110:NCU07165
gene id: 367110:NCU07165
uniprot id: Q870Y1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

367110:NCU06801
gene id: 367110:NCU06801
uniprot id: F5HBR2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the kynurenine formamidase family.
messages: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.
messages: Homodimer.
messages: The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.

367110:NCU02103
gene id: 367110:NCU02103
uniprot id: Q7SDN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

367110:NCU02969
gene id: 367110:NCU02969
uniprot id: F5HHR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Membrane

367110:NCU06695
gene id: 367110:NCU06695
uniprot id: Q01359
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 11 subunits. The complex is composed of a catalytic core of 3 subunits Cox1, Cox2 and Cox3, encoded in the mitochondrial DNA, and 8 supernumerary subunits Cox4, Cox5a/Cox5, Cox6, Cox7, Cox8, Cox7a/Cox9, Cox6b/Cox12 and Cox6a/Cox13, which are encoded in the nuclear genome (PubMed:31316820). The complex exists as a monomer or a dimer and forms respiratory supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in various different assemblies (supercomplexes I(1)IV(1), I(1)III(3)IV(2), III(2)IV(1) and III(2)IV(2) as well as larger supercomplexes of compositions like I(1)III(2)IV(5-6)) (PubMed:17873079).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of Cox2 and heme A of Cox1 to the active site in Cox1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

367110:NCU10226
gene id: 367110:NCU10226
uniprot id: Q7S589
names: Similarity
messages: Belongs to the RutC family.

367110:NCU09747
gene id: 367110:NCU09747
uniprot id: Q7SEH8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.

367110:NCU06047
gene id: 367110:NCU06047
uniprot id: Q7S503
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

367110:NCU02149
gene id: 367110:NCU02149
uniprot id: Q7SER7
names: Similarity
messages: Belongs to the PET191 family.

367110:NCU09808
gene id: 367110:NCU09808
uniprot id: Q7SDJ3
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

367110:NCU06381
gene id: 367110:NCU06381
uniprot id: Q7S9G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 17 family.
messages: cell wall

367110:NCU07982
gene id: 367110:NCU07982
uniprot id: V5INN6
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

367110:NCU03328
gene id: 367110:NCU03328
uniprot id: Q1K4Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 61 family.
messages: Secreted

367110:NCU05770
gene id: 367110:NCU05770
uniprot id: Q8X182
names: Activity Regulation
names: Cofactor
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.
messages: Cytoplasm
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.
messages: Induced in late stationary growth phase.
messages: Inhibited by KCN.

367110:NCU08388
gene id: 367110:NCU08388
uniprot id: Q7SD63
names: Similarity
messages: Belongs to the CSN12 family.

367110:NCU00070
gene id: 367110:NCU00070
uniprot id: Q7RX80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ING family.
messages: Nucleus

367110:NCU08791
gene id: 367110:NCU08791
uniprot id: Q9C168
names: Developmental Stage
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the catalase family.
messages: During prestationary growth. By ethanol and in the presence of air by heat shock. Inactivated by isopropanol and 20 mM 3-amino-1,2,4-triazole.
messages: Glycosylated; with alpha-glucose and/or alpha-mannose.
messages: Homotetramer.
messages: Main catalase activity in conidia, during germination of conidia, and initial growth.
messages: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
messages: cell wall

367110:NCU09006
gene id: 367110:NCU09006
uniprot id: U9W3H6
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

367110:NCU03036
gene id: 367110:NCU03036
uniprot id: Q7SDH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAN1 family.
messages: Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
messages: Nucleus

367110:NCU09923
gene id: 367110:NCU09923
uniprot id: F5HDC6
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

367110:NCU02530
gene id: 367110:NCU02530
uniprot id: Q7SHT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space
messages: Required for the assembly of cytochrome c oxidase.

367110:NCU01132
gene id: 367110:NCU01132
uniprot id: F5HC09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU08956
gene id: 367110:NCU08956
uniprot id: Q1K6L0
names: Similarity
messages: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.

367110:NCU07948
gene id: 367110:NCU07948
uniprot id: Q7S936
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auto-ADP-ribosylated.
messages: Belongs to the fungal surface NADase family.
messages: Both aliphatic amines and carboxylic acids are able to inhibit non-competitively the catalytic activity (PubMed:9193681). The inhibition depends on the non-polar moiety of the substances (PubMed:9193681). Dioxane also acts as an inhibitor of NADase activity (PubMed:9193681). Auto-ADP-ribosylation acts as a mechanism of self-inactivation by its substrate (PubMed:9787786).
messages: Conidial surface nicotinamide adenine dinucleotide glycohydrolase that cleave NAD(+) and NADP(+) but not their reduced counterparts, NADH and NADPH (PubMed:6260480, PubMed:33712585). Lacks both ADP-ribosyl cyclase and base exchange activity and does not mediate synthesis of calcium messengers cADPR or NAADP (PubMed:33712585). Its function is correlated with aerial hyphae formation and conidiogenesis, but its physiological role is still obscure (PubMed:165174, PubMed:131723). Is able to ADP-ribosylate itself for self-inactivation (PubMed:9787786).
messages: Does not affect the growth of aerial hyphae, conidiation or conidial germination.
messages: Expression is up-regulated in mycelia grown in a zinc-deficient medium (PubMed:14814150). Expression is strongly induced with the formation of aerial hyphae, accumulates in conidia and decreases very fast as the mature conidia germinate (Ref.3, PubMed:4384627, PubMed:5111767, PubMed:131723). Induced by the presence of proteins in the culture medium (PubMed:6237174). Low concentrations of sucrose or glucose, Casamino acids or some amino acids such as methionine, cysteine, phenylalanine and tryptophan strongly repress the expression (PubMed:6237174).
messages: Homodimer.
messages: N-glycosylated.
messages: Secreted

367110:NCU00773
gene id: 367110:NCU00773
uniprot id: Q7SFV6
names: Subcellular Location Annotation
messages: Secreted

367110:NCU09841
gene id: 367110:NCU09841
uniprot id: Q7S0H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
messages: Cytoplasm

367110:NCU00983
gene id: 367110:NCU00983
uniprot id: Q7SGD9
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06027
gene id: 367110:NCU06027
uniprot id: P11637
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Similarity
messages: Expression is regulated by the qa-1f activator.
messages: In the 2nd section; belongs to the type-I 3-dehydroquinase family.
messages: In the N-terminal section; belongs to the shikimate kinase family.
messages: Leads to constitutive levels of expression of the qa-2, qa-1F and qa-x genes.
messages: The COOH-terminal region is involved in the binding to its target whereas the N-terminal region bind to the inducer.
messages: Transcription repressor; part of the qa gene cluster that mediates the catabolism of quinic acid (QA) and as such, allows the use of QA as a sole carbon source (PubMed:2525625, PubMed:3010294, PubMed:1533844). Negatively regulates transcription of the quinate utilization pathway genes, probably via binding directly to the qa-1f activator protein (PubMed:3010294, PubMed:1533844). Probably acts as a molecular sensor that detects the presence of quinate pathway intermediates as a prerequisite for the presumed conformational changes necessary for the control of transcription regulation (PubMed:3010294).

367110:NCU08578
gene id: 367110:NCU08578
uniprot id: Q7S021
names: Similarity
messages: Belongs to the OSBP family.

367110:NCU09434
gene id: 367110:NCU09434
uniprot id: Q1K660
names: Similarity
messages: Belongs to the argonaute family.

367110:NCU04350
gene id: 367110:NCU04350
uniprot id: Q7RX26
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.

367110:NCU08137
gene id: 367110:NCU08137
uniprot id: Q7S3Z3
names: Subcellular Location Annotation
messages: Mitochondrion

367110:NCU02533
gene id: 367110:NCU02533
uniprot id: Q7SHT0
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

367110:NCU01078
gene id: 367110:NCU01078
uniprot id: Q1K894
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

367110:NCU04352
gene id: 367110:NCU04352
uniprot id: Q7RVP6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.

367110:NCU05492
gene id: 367110:NCU05492
uniprot id: Q7S6U7
names: Subcellular Location Annotation
messages: Membrane

367110:NCU00801
gene id: 367110:NCU00801
uniprot id: Q7SCU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU06493
gene id: 367110:NCU06493
uniprot id: Q05425
names: Function
names: Similarity
names: Subunit
messages: Belongs to the G-alpha family. G(q) subfamily.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

367110:NCU02253
gene id: 367110:NCU02253
uniprot id: V5IL42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 9 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

367110:NCU00711
gene id: 367110:NCU00711
uniprot id: Q7SET5
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06928
gene id: 367110:NCU06928
uniprot id: Q7S3C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWC3 family.
messages: Nucleus

367110:NCU08040
gene id: 367110:NCU08040
uniprot id: V5INP8
uniprot id: V5IQD6
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
messages: Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.

367110:NCU09571
gene id: 367110:NCU09571
uniprot id: Q7S4M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRM6/GCD10 family.
messages: Nucleus

367110:NCU00565
gene id: 367110:NCU00565
uniprot id: Q7SF84
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion

367110:NCU06394
gene id: 367110:NCU06394
uniprot id: Q7S9F3
names: Similarity
messages: Belongs to the actin family.

367110:NCU07440
gene id: 367110:NCU07440
uniprot id: Q7RW07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPF family.
messages: Nucleus

367110:NCU00446
gene id: 367110:NCU00446
uniprot id: Q7RXZ8
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

367110:NCU16024
gene id: 367110:NCU16024
uniprot id: Q08656
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase protein 8 family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).
messages: Mitochondrion membrane

367110:NCU01514
gene id: 367110:NCU01514
uniprot id: Q1K5K2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

367110:NCU05275
gene id: 367110:NCU05275
uniprot id: P0C224
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Component of the large ribosomal subunit (LSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. eL40 is essential for translation of a subset of cellular transcripts, including stress response transcripts, such as DDR2.
messages: Cytoplasm
messages: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus
messages: Ubiquitin is encoded by 3 different genes. Crp-79 is synthesized as a polyprotein with one copy of ubiquitin fused to ribosomal protein eL40. Crp-6/ubi-3 is a polyprotein with one copy of ubiquitin fused to ribosomal protein eS31. Ubi is a polyprotein containing 4 exact head to tail repeats of ubiquitin.

367110:NCU00257
gene id: 367110:NCU00257
uniprot id: Q7RVR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunit 4 family.
messages: centrosome
messages: sarcomere
messages: stress fiber

367110:NCU06697
gene id: 367110:NCU06697
uniprot id: Q1K741
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Converts sphingomyelin to ceramide.

367110:NCU05735
gene id: 367110:NCU05735
uniprot id: Q7SB78
names: Subcellular Location Annotation
messages: Membrane

367110:NCU00470
gene id: 367110:NCU00470
uniprot id: U9W3E1
uniprot id: U9W3J3
names: Function
names: Similarity
messages: Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation.
messages: Belongs to the rad9 family.

367110:NCU01978
gene id: 367110:NCU01978
uniprot id: Q7SE82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor potential (TRP) ion channel family.
messages: Membrane

367110:NCU05645
gene id: 367110:NCU05645
uniprot id: Q7S615
names: Similarity
messages: Belongs to the Luc7 family.

367110:NCU04494
gene id: 367110:NCU04494
uniprot id: Q7RYB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbohydrate esterase 1 (CE1) family.
messages: Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.
messages: Secreted

367110:NCU01843
gene id: 367110:NCU01843
uniprot id: F5HG81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

367110:NCU11288
gene id: 367110:NCU11288
uniprot id: A7UWH7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24B family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.

367110:NCU04133
gene id: 367110:NCU04133
uniprot id: Q1K7M0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: May be involved in vacuolar sorting and osmoregulation.
messages: Vacuole membrane

367110:NCU04799
gene id: 367110:NCU04799
uniprot id: Q7S6N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN (By similarity).
messages: Cytoplasm
messages: Nucleus

367110:NCU07756
gene id: 367110:NCU07756
uniprot id: Q7S1S2
names: Subcellular Location Annotation
messages: Membrane

367110:NCU08515
gene id: 367110:NCU08515
uniprot id: P11593
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).
messages: Vacuole membrane

367110:NCU08032
gene id: 367110:NCU08032
uniprot id: Q7SAK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage (By similarity).
messages: tRNA splicing endonuclease is a heterotetramer composed of tsp-2/sen2, tsp-1/sen15, tsp-4/sen34 and tsp-5/sen54. Interacts directly with tsp-1/sen15 (By similarity).

367110:NCU09486
gene id: 367110:NCU09486
uniprot id: Q7SBZ7
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

367110:NCU03485
gene id: 367110:NCU03485
uniprot id: Q1K4M2
names: Subcellular Location Annotation
messages: Cytoplasm

367110:NCU00527
gene id: 367110:NCU00527
uniprot id: Q7SDL7
names: Similarity
messages: Belongs to the MGR2 family.

367110:NCU03055
gene id: 367110:NCU03055
uniprot id: Q7SCI8
names: Similarity
messages: Belongs to the glycosyltransferase 34 family.

367110:NCU09728
gene id: 367110:NCU09728
uniprot id: Q7SEJ5
names: Similarity
messages: Belongs to the peptidase A1 family.

367110:NCU03815
gene id: 367110:NCU03815
uniprot id: Q1K7G0
names: Subcellular Location Annotation
messages: Membrane

367110:NCU00055
gene id: 367110:NCU00055
uniprot id: Q7RW43
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

367110:NCU00378
gene id: 367110:NCU00378
uniprot id: Q7RYT1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

367110:NCU06182
gene id: 367110:NCU06182
uniprot id: Q7RVY6
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

367110:NCU05121
gene id: 367110:NCU05121
uniprot id: Q1K5M0
names: Similarity
messages: Belongs to the glycosyl hydrolase 45 (cellulase K) family.

367110:NCU00965
gene id: 367110:NCU00965
uniprot id: Q7SGF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS2 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU03436
gene id: 367110:NCU03436
uniprot id: Q1K5B6
names: Similarity
messages: Belongs to the PPP phosphatase family.

367110:NCU04087
gene id: 367110:NCU04087
uniprot id: Q7RWM2
names: Similarity
messages: Belongs to the AHA1 family.

367110:NCU03695
gene id: 367110:NCU03695
uniprot id: Q1K800
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Mitochondrion inner membrane

367110:NCU05600
gene id: 367110:NCU05600
uniprot id: Q7S6W4
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

367110:NCU07225
gene id: 367110:NCU07225
uniprot id: Q1K5S8
names: Similarity
messages: Belongs to the glycosyl hydrolase 11 (cellulase G) family.

367110:NCU03557
gene id: 367110:NCU03557
uniprot id: Q1K4W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAK10 family.
messages: Cytoplasm

367110:NCU07712
gene id: 367110:NCU07712
uniprot id: Q7S9J4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
messages: Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

367110:NCU07082
gene id: 367110:NCU07082
uniprot id: Q7S6E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Membrane

367110:NCU05257
gene id: 367110:NCU05257
uniprot id: Q7S886
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU04293
gene id: 367110:NCU04293
uniprot id: Q1K778
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

367110:NCU11313
gene id: 367110:NCU11313
uniprot id: A7UWR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU05235
gene id: 367110:NCU05235
uniprot id: Q7S8U9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

367110:NCU02078
gene id: 367110:NCU02078
uniprot id: Q7SEY6
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU07971
gene id: 367110:NCU07971
uniprot id: Q7S914
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

367110:NCU02951
gene id: 367110:NCU02951
uniprot id: Q7SHF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Mitochondrion

367110:NCU02480
gene id: 367110:NCU02480
uniprot id: V5IP82
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU16367
gene id: 367110:NCU16367
uniprot id: V5IPA4
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06429
gene id: 367110:NCU06429
uniprot id: Q7RYY6
names: Similarity
messages: Belongs to the alpha-actinin family.

367110:NCU08990
gene id: 367110:NCU08990
uniprot id: Q7S2X9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

367110:NCU05785
gene id: 367110:NCU05785
uniprot id: Q7S5Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor potential (TRP) ion channel family.
messages: Membrane

367110:NCU04741
gene id: 367110:NCU04741
uniprot id: Q7S6G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex DUO1 family.
messages: Nucleus
messages: kinetochore

367110:NCU08989
gene id: 367110:NCU08989
uniprot id: Q7S2Y0
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

367110:NCU09826
gene id: 367110:NCU09826
uniprot id: Q7S1R6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL57 subfamily.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins. mL57 forms a heterodimer with mL44 and stabilizes rRNA expansion segments 1/2 at a membrane-facing protuberance close to the point of attachment of the ribosome to the translocon in the membrane.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU04528
gene id: 367110:NCU04528
uniprot id: P06811
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multicopper oxidase family.
messages: Binds 4 Cu cations per monomer.
messages: Lignin degradation and detoxification of lignin-derived products.
messages: Secreted

367110:NCU00138
gene id: 367110:NCU00138
uniprot id: Q7RWV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 4 family.
messages: Membrane

367110:NCU07351
gene id: 367110:NCU07351
uniprot id: Q7S165
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-glucuronidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Releases 4-O-methylglucuronic acid from xylan.
messages: Belongs to the glycosyl hydrolase 67 family.
messages: Secreted

367110:NCU04020
gene id: 367110:NCU04020
uniprot id: Q1K609
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

367110:NCU02775
gene id: 367110:NCU02775
uniprot id: Q7SE19
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU03194
gene id: 367110:NCU03194
uniprot id: Q7SGX5
names: Similarity
messages: In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.

367110:NCU05888
gene id: 367110:NCU05888
uniprot id: Q7S520
names: Similarity
messages: Belongs to the NtaA/SnaA/DszA monooxygenase family.

367110:NCU08861
gene id: 367110:NCU08861
uniprot id: Q1K730
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL27 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU00830
gene id: 367110:NCU00830
uniprot id: Q7SEA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

367110:NCU00134
gene id: 367110:NCU00134
uniprot id: Q7RWV9
uniprot id: U9WGQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease (By similarity).
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.

367110:NCU15835
gene id: 367110:NCU15835
uniprot id: V5IKI3
uniprot id: V5IMC7
names: Similarity
messages: Belongs to the SAPS family.

367110:NCU07974
gene id: 367110:NCU07974
uniprot id: Q7SAR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 61 family.
messages: Secreted

367110:NCU05228
gene id: 367110:NCU05228
uniprot id: Q7S8I0
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06168
gene id: 367110:NCU06168
uniprot id: Q7S5C0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster facilitates the reduction of the catalytic iron-sulfur cluster in the dph-1 subunit.
messages: Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of dph-1, dph-2, dph-3 and a NADH-dependent reductase, predominantly cbr-1.
messages: Cytoplasm
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. Dph-1 and dph-2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising dph-3 and a NADH-dependent reductase, predominantly cbr-1 (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the dph-1 subunit (By similarity).

367110:NCU09373
gene id: 367110:NCU09373
uniprot id: Q7SCN8
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

367110:NCU09000
gene id: 367110:NCU09000
uniprot id: Q7S2X0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FYV10 family.
messages: Cytoplasm
messages: Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.
messages: Nucleus

367110:NCU08001
gene id: 367110:NCU08001
uniprot id: Q7SAN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRO1 family.
messages: Cytoplasm
messages: Endosome
messages: Involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles.

367110:NCU05731
gene id: 367110:NCU05731
uniprot id: P42115
names: Function
names: Similarity
messages: Belongs to the thioredoxin family.
messages: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.

367110:NCU05433
gene id: 367110:NCU05433
uniprot id: Q1K8I6
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU09698
gene id: 367110:NCU09698
uniprot id: Q7S776
names: Subcellular Location Annotation
messages: Membrane

367110:NCU02507
gene id: 367110:NCU02507
uniprot id: Q7SHV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

367110:NCU03298
gene id: 367110:NCU03298
uniprot id: Q7SEP4
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

367110:NCU05288
gene id: 367110:NCU05288
uniprot id: Q7S909
names: Similarity
messages: Belongs to the Rab GDI family.

367110:NCU03660
gene id: 367110:NCU03660
uniprot id: Q1K6P7
names: Subcellular Location Annotation
messages: Membrane

367110:NCU00203
gene id: 367110:NCU00203
uniprot id: Q7RXM3
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.

367110:NCU06861
gene id: 367110:NCU06861
uniprot id: Q7S0F4
names: Similarity
messages: Belongs to the glycosyl hydrolase 43 family.

367110:NCU04191
gene id: 367110:NCU04191
uniprot id: Q9HE87
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA (By similarity). The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs (By similarity). Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1) (By similarity).
messages: Divalent metal cation.
messages: Nucleus

367110:NCU10107
gene id: 367110:NCU10107
uniprot id: A7UWK4
names: Similarity
messages: Belongs to the LacAB/RpiB family.

367110:NCU06380
gene id: 367110:NCU06380
uniprot id: Q7S9G7
names: Subcellular Location Annotation
messages: Membrane

367110:NCU00985
gene id: 367110:NCU00985
uniprot id: Q7SGD7
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

367110:NCU03764
gene id: 367110:NCU03764
uniprot id: Q9C2I5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Component of the NOP7 complex, composed of erb1, nop7 and ytm1. The complex is held together by erb1, which interacts with nop7 via its N-terminal domain and with ytm1 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome. Interacts (via UBL domain) with rbg-35/mdn1 (via VWFA/MIDAS domain).
messages: Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

367110:NCU08056
gene id: 367110:NCU08056
uniprot id: Q7SGM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.
messages: Membrane

367110:NCU07263
gene id: 367110:NCU07263
uniprot id: Q7S952
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

367110:NCU02343
gene id: 367110:NCU02343
uniprot id: Q7S412
names: Similarity
messages: Belongs to the glycosyl hydrolase 51 family.

367110:NCU11345
gene id: 367110:NCU11345
uniprot id: A7UWX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS1 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Mitochondrion

367110:NCU01473
gene id: 367110:NCU01473
uniprot id: Q7RXV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU07489
gene id: 367110:NCU07489
uniprot id: V5IQF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-Z subfamily.
messages: Cytoplasm

367110:NCU07196
gene id: 367110:NCU07196
uniprot id: Q1K5U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.
messages: cytoskeleton

367110:NCU01300
gene id: 367110:NCU01300
uniprot id: Q9HEG3
names: Similarity
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.

367110:NCU12087
gene id: 367110:NCU12087
uniprot id: V5ILY9
names: Similarity
messages: Belongs to the XPC family.

367110:NCU04512
gene id: 367110:NCU04512
uniprot id: Q7RY51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HIR3 family.
messages: Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.
messages: Nucleus

367110:NCU09814
gene id: 367110:NCU09814
uniprot id: Q7SDI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup84/Nup107 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: Part of the nuclear pore complex (NPC).
messages: nuclear pore complex

367110:NCU07724
gene id: 367110:NCU07724
uniprot id: Q7S8R5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat MDV1/CAF4 family.
messages: Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division (By similarity).
messages: Mitochondrion outer membrane

367110:NCU09100
gene id: 367110:NCU09100
uniprot id: Q7SFQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-O/MCM21 family.
messages: Nucleus

367110:NCU04963
gene id: 367110:NCU04963
uniprot id: Q7S3Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU04120
gene id: 367110:NCU04120
uniprot id: P61859
names: Function
names: Miscellaneous
names: PTM
names: Similarity
messages: Belongs to the calmodulin family.
messages: Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
messages: This protein has four functional calcium-binding sites.
messages: Trimethylation of Lys-116 observed in other calmodulins is absent here.

367110:NCU06005
gene id: 367110:NCU06005
uniprot id: Q7S2F2
names: Similarity
messages: Belongs to the FGGY kinase family.

367110:NCU06864
gene id: 367110:NCU06864
uniprot id: Q7S0C3
names: Similarity
messages: Belongs to the MIT1/WOR1 family.

367110:NCU04229
gene id: 367110:NCU04229
uniprot id: Q7S7H0
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU04270
gene id: 367110:NCU04270
uniprot id: Q7RVU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASC3 family.
messages: Cytoplasm
messages: Nucleus

367110:NCU07404
gene id: 367110:NCU07404
uniprot id: Q7S1L0
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

367110:NCU06209
gene id: 367110:NCU06209
uniprot id: Q7SBB4
names: Similarity
messages: Belongs to the UPF0357 family.

367110:NCU00033
gene id: 367110:NCU00033
uniprot id: U9W879
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

367110:NCU01341
gene id: 367110:NCU01341
uniprot id: Q1K7T5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus
messages: U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

367110:NCU00184
gene id: 367110:NCU00184
uniprot id: Q7RXA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the USE1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU01198
gene id: 367110:NCU01198
uniprot id: Q1K841
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLE1 family.
messages: nuclear pore complex

367110:NCU08384
gene id: 367110:NCU08384
uniprot id: Q7SD67
names: Similarity
messages: Belongs to the aldo/keto reductase family.

367110:NCU09290
gene id: 367110:NCU09290
uniprot id: Q7S0Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

367110:NCU04247
gene id: 367110:NCU04247
uniprot id: P38673
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family. ARP1 subfamily.
messages: Involved in nuclear migration. May function as a component of the dynactin complex which activates force generation by cytoplasmic dynein.
messages: cytoskeleton

367110:NCU01333
gene id: 367110:NCU01333
uniprot id: Q7S7W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

367110:NCU05317
gene id: 367110:NCU05317
uniprot id: Q7S8L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.
messages: Secreted

367110:NCU05521
gene id: 367110:NCU05521
uniprot id: V5ILG0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

367110:NCU07531
gene id: 367110:NCU07531
uniprot id: Q7S316
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane

367110:NCU06768
gene id: 367110:NCU06768
uniprot id: F5HIJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU04806
gene id: 367110:NCU04806
uniprot id: Q7S6M9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Mitochondrion

367110:NCU09378
gene id: 367110:NCU09378
uniprot id: Q7SCW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Nucleus

367110:NCU10715
gene id: 367110:NCU10715
uniprot id: V5ILF2
names: Similarity
messages: Belongs to the OSBP family.

367110:NCU00860
gene id: 367110:NCU00860
uniprot id: Q7SFH1
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06355
gene id: 367110:NCU06355
uniprot id: Q7S9V1
names: Function
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.

367110:NCU00320
gene id: 367110:NCU00320
uniprot id: U9W385
uniprot id: U9W8J1
names: Similarity
messages: Belongs to the peptidase C19 family.

367110:NCU03629
gene id: 367110:NCU03629
uniprot id: Q1K7Q5
names: Similarity
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.

367110:NCU07246
gene id: 367110:NCU07246
uniprot id: Q7RW59
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU06706
gene id: 367110:NCU06706
uniprot id: Q1K6Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP5 family.
messages: Cytoplasm
messages: Nucleus

367110:NCU00101
gene id: 367110:NCU00101
uniprot id: Q7RYM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGX family.
messages: Endoplasmic reticulum membrane
messages: Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase gim-1/gpi14 (By similarity).

367110:NCU09703
gene id: 367110:NCU09703
uniprot id: Q7S2S3
names: Similarity
messages: Belongs to the alpha-acetolactate decarboxylase family.

367110:NCU11252
gene id: 367110:NCU11252
uniprot id: A7UW89
names: Similarity
messages: Belongs to the cyclin family. Cyclin C subfamily.

367110:NCU09089
gene id: 367110:NCU09089
uniprot id: V5INR8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS30 family.

367110:NCU04150
gene id: 367110:NCU04150
uniprot id: Q7S7U0
names: Similarity
messages: Belongs to the MAK16 family.

367110:NCU08857
gene id: 367110:NCU08857
uniprot id: V5IL61
uniprot id: V5INK6
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU01503
gene id: 367110:NCU01503
uniprot id: Q1K5K8
names: Subcellular Location Annotation
messages: nucleolus

367110:NCU02084
gene id: 367110:NCU02084
uniprot id: Q7SEY0
names: Similarity
messages: Belongs to the arginase family.

367110:NCU09975
gene id: 367110:NCU09975
uniprot id: V5IP17
uniprot id: V5IP78
uniprot id: V5IRF4
names: Subcellular Location Annotation
messages: Membrane

367110:NCU09287
gene id: 367110:NCU09287
uniprot id: Q7S0R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

367110:NCU05706
gene id: 367110:NCU05706
uniprot id: Q7SBN2
names: Similarity
messages: Belongs to the GST superfamily.

367110:NCU01424
gene id: 367110:NCU01424
uniprot id: Q1K6L7
names: Similarity
messages: Belongs to the Gfa family.

367110:NCU00489
gene id: 367110:NCU00489
uniprot id: Q7RV52
names: Similarity
messages: Belongs to the universal ribosomal protein uS3 family.

367110:NCU07504
gene id: 367110:NCU07504
uniprot id: Q7SG38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG22 family.
messages: Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation (By similarity).
messages: Vacuole membrane

367110:NCU00107
gene id: 367110:NCU00107
uniprot id: Q7RYM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M76 family.
messages: Has a dual role in the assembly of mitochondrial ATPase. Acts as a protease that removes N-terminal residues of mitochondrial ATPase CF(0) subunit 6 at the intermembrane space side. Also involved in the correct assembly of the membrane-embedded ATPase CF(0) particle, probably mediating association of subunit 6 with the subunit 9 ring (By similarity).
messages: Mitochondrion inner membrane

367110:NCU08425
gene id: 367110:NCU08425
uniprot id: Q1K8H4
names: Subcellular Location Annotation
messages: Membrane

367110:NCU09642
gene id: 367110:NCU09642
uniprot id: V5IMX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

367110:NCU06277
gene id: 367110:NCU06277
uniprot id: Q7SB64
names: Similarity
messages: Belongs to the MAP65/ASE1 family.

367110:NCU10359
gene id: 367110:NCU10359
uniprot id: A7UWF2
names: Similarity
messages: Belongs to the neutral ceramidase family.

367110:NCU08471
gene id: 367110:NCU08471
uniprot id: Q9P567
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

367110:NCU01842
gene id: 367110:NCU01842
uniprot id: Q872U8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: Nucleus
messages: Plays a central role in chromosome cohesion during cell division by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms.
messages: centromere

367110:NCU01099
gene id: 367110:NCU01099
uniprot id: Q1K878
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Component of the GSE complex.
messages: GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.

367110:NCU06171
gene id: 367110:NCU06171
uniprot id: Q7SAT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PAN1 family.
messages: Cell membrane
messages: Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).
messages: Component of the PAN1 actin cytoskeleton-regulatory complex.
messages: Endosome membrane
messages: actin patch

367110:NCU09183
gene id: 367110:NCU09183
uniprot id: Q7S332
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
messages: Cytoplasm
messages: Homodimer.

367110:NCU03702
gene id: 367110:NCU03702
uniprot id: Q9HE26
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: By homology to other fibrillarins, some or all of the N-terminal domain arginines are modified to asymmetric dimethylarginine (DMA).
messages: Component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles.
messages: S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (By similarity).
messages: nucleolus

367110:NCU00109
gene id: 367110:NCU00109
uniprot id: U9W318
names: Similarity
messages: Belongs to the TIP41 family.

367110:NCU07454
gene id: 367110:NCU07454
uniprot id: Q7SF01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBT5 family.
messages: Membrane

367110:NCU04886
gene id: 367110:NCU04886
uniprot id: Q7S080
names: Subcellular Location Annotation
messages: Membrane

367110:NCU00734
gene id: 367110:NCU00734
uniprot id: Q7SEE4
names: Similarity
messages: Belongs to the peptidase C48 family.

367110:NCU09283
gene id: 367110:NCU09283
uniprot id: Q7S1M4
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

367110:NCU16423
gene id: 367110:NCU16423
uniprot id: V5IQY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Nucleus

367110:NCU16833
gene id: 367110:NCU16833
uniprot id: V5IQE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mL40 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins. mL40 is binding to NAD.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU02369
gene id: 367110:NCU02369
uniprot id: Q7S4V7
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

367110:NCU08850
gene id: 367110:NCU08850
uniprot id: Q01408
names: Function
names: Similarity
messages: Belongs to the uve1/UvsE family.
messages: Endonuclease for the repair of UV-irradiated DNA. Involved in the excision of cyclobutane pyrimidine dimers (CPD) and 6-4 pyrimidine pyrimidones (6-4PP) which forms the UV damage repair (UVDR) pathway.

367110:NCU09465
gene id: 367110:NCU09465
uniprot id: Q7SC15
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPH3 family.
messages: Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of dph-1, dph-2, dph-3 and a NADH-dependent reductase, predominantly cbr-1.
messages: Cytoplasm
messages: Nucleus
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. Dph-1 and dph-2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising dph-3 and a NADH-dependent reductase, predominantly cbr-1. Acts as an electron donor to reduce the Fe-S cluster in dph1-dph2 keeping the [4Fe-4S] clusters in the active and reduced state. Restores iron to dph-1-dph-2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM. Associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine).
messages: The DPH-type metal-binding (MB) domain can also bind zinc. However, iron is the physiological binding partner as zinc binding impairs the protein electron donor function.

367110:NCU01554
gene id: 367110:NCU01554
uniprot id: Q1K4Y2
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU02500
gene id: 367110:NCU02500
uniprot id: Q01301
names: Developmental Stage
names: Function
names: Induction
names: Subcellular Location Annotation
messages: By light and circadian rhythms.
messages: During conidial development. Expressed with a 22 hours rhythm under the control of the circadian biological clock.
messages: Pheromone that is regulated by the circadian clock. Expression is mating type specific and under the control of the mating type locus. Involved in conidiation.
messages: Secreted

367110:NCU11347
gene id: 367110:NCU11347
uniprot id: A7UWX8
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03533
gene id: 367110:NCU03533
uniprot id: Q9UV10
names: Function
messages: Involved in the non-self-recognition during asexual growth of N.crassa. This process involves restriction of heterokaryon formation via genetic differences at 11 het loci, including mating type.

367110:NCU03341
gene id: 367110:NCU03341
uniprot id: Q1K527
names: Similarity
messages: Belongs to the SEC6 family.

367110:NCU02541
gene id: 367110:NCU02541
uniprot id: Q7SHS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

367110:NCU00133
gene id: 367110:NCU00133
uniprot id: Q7RWW0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).
messages: Forms a stable heterodimer with ctc-2/spt16. The dimer of ctc-1 and ctc-2 weakly associates with multiple molecules of nhp-1/nhp6 to form the FACT complex (By similarity).
messages: In contrast to the orthologous protein in animals and plants, this protein does not contain a HMG box DNA-binding domain. This function may instead be provided by the HMG box of the associated nhp-1 protein in the FACT complex of fungi.
messages: Nucleus

367110:NCU00721
gene id: 367110:NCU00721
uniprot id: Q7SES5
names: Subcellular Location Annotation
messages: Membrane

367110:NCU03953
gene id: 367110:NCU03953
uniprot id: O47950
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Complex I is composed of about 40 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Mitochondrion

367110:NCU01054
gene id: 367110:NCU01054
uniprot id: Q1K8B2
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU01347
gene id: 367110:NCU01347
uniprot id: Q1K7T1
names: Similarity
messages: Belongs to the GST superfamily.

367110:NCU08648
gene id: 367110:NCU08648
uniprot id: Q7S8Q5
names: Similarity
messages: Belongs to the nuclease type I family.

367110:NCU01959
gene id: 367110:NCU01959
uniprot id: Q10115
names: Caution
names: Developmental Stage
names: Function
names: Similarity
messages: It is uncertain whether Met-1 or Met-6 is the initiator.
messages: Only present in A-cells and in a/A diploid cells.
messages: Required, together with mating-type protein A-3, for efficient ascospore formation.
messages: To P.anserina SMR1.

367110:NCU01331
gene id: 367110:NCU01331
uniprot id: Q1K7U2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

367110:NCU09331
gene id: 367110:NCU09331
uniprot id: Q7SD54
names: Similarity
messages: Belongs to the RutC family.

367110:NCU03300
gene id: 367110:NCU03300
uniprot id: V5IRL8
names: Similarity
messages: Belongs to the 14-3-3 family.

367110:NCU02624
gene id: 367110:NCU02624
uniprot id: Q7SDI6
names: Similarity
messages: Belongs to the cytochrome P450 family.

367110:NCU06227
gene id: 367110:NCU06227
uniprot id: Q7SBS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BMT2 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.
messages: nucleolus

367110:NCU07340
gene id: 367110:NCU07340
uniprot id: Q7SA23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 7 (cellulase C) family.
messages: Secreted

367110:NCU11248
gene id: 367110:NCU11248
uniprot id: A7UW84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

367110:NCU11181
gene id: 367110:NCU11181
uniprot id: P0C583
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small GTPase superfamily. SAR1 family.
messages: COPII is composed of at least 5 proteins: the sec23/24 complex, the sec13/31 complex and vtr-7/sar1.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. Vtr-7/sar1 controls the coat assembly in a stepwise manner. Activated sar1-GTP binds to membranes first and recruits the sec23/24 complex. These sec23/24-sar1 prebudding intermediates are then collected by the sec13/31 complex as subunits polymerize to form coated transport vesicles. Conversion to sar1-GDP triggers coat release and recycles COPII subunits (By similarity).

367110:NCU02289
gene id: 367110:NCU02289
uniprot id: Q7RVS7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

367110:NCU06767
gene id: 367110:NCU06767
uniprot id: Q7SCC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the activator 1 large subunit family.
messages: Nucleus

367110:NCU06452
gene id: 367110:NCU06452
uniprot id: Q7RYW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.
messages: Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.
messages: Mitochondrion

367110:NCU05270
gene id: 367110:NCU05270
uniprot id: Q7S829
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.

367110:NCU06606
gene id: 367110:NCU06606
uniprot id: P07056
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 10 subunits. The complex is composed of 3 respiratory subunits cytochrome b (cob), cytochrome c1 (cyt-1) and Rieske protein (fes-1), 2 core protein subunits pep and ucr-1, and 5 low-molecular weight protein subunits qcr6, qcr7, qcr8, qcr9 and probably NCU16844/qcr10 (PubMed:226365, PubMed:6273583, PubMed:18251112, PubMed:6302289). The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplexes SCI(1)III(2), SCIII(2)IV(1) and SCIII(2)IV(2) as well as higher order I(x)III(y)IV(z) megacomplexes) (PubMed:17873079, PubMed:19239619).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c (PubMed:3015618) (Probable). The Rieske protein is a catalytic core subunit containing a [2Fe-2S] iron-sulfur cluster. It cycles between 2 conformational states during catalysis to transfer electrons from the quinol bound in the Q(0) site in cytochrome b to cytochrome c1 (By similarity).
messages: Mitochondrion inner membrane
messages: Mutants display reduced growth, are female sterile and lack active complex III.
messages: Processed by both the mitochondrial processing peptidase (MPP) and the mitochondrial intermediate protease (MIP). Initially, MPP removes 25 amino acids from the newly imported precursor in the mitochondrial matrix. This proteolytic processing is then followed by a second proteolytic cleavage by MIP, which removes an octapeptide to generate mature-sized Rieske protein.
messages: The Rieske protein is a high potential 2Fe-2S protein.

367110:NCU00958
gene id: 367110:NCU00958
uniprot id: Q7SGG4
names: Similarity
messages: Belongs to the PP2C family.

367110:NCU02927
gene id: 367110:NCU02927
uniprot id: Q7SHH7
names: Similarity
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.

367110:NCU03059
gene id: 367110:NCU03059
uniprot id: Q7SCK0
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.

367110:NCU00081
gene id: 367110:NCU00081
uniprot id: Q7RX69
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

367110:NCU04646
gene id: 367110:NCU04646
uniprot id: Q8NIZ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.
messages: Heterodimer of a small subunit and a large subunit.

367110:NCU06233
gene id: 367110:NCU06233
uniprot id: Q7SBS3
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU02932
gene id: 367110:NCU02932
uniprot id: Q7SHH2
names: Function
names: Similarity
messages: Belongs to the endosulfine family.
messages: Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.

367110:NCU06238
gene id: 367110:NCU06238
uniprot id: Q7SBR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: Nucleus
messages: Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex.

367110:NCU02528
gene id: 367110:NCU02528
uniprot id: Q7SHT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PINX1 family.
messages: Involved in rRNA-processing at A0, A1 and A2 sites and regulates negatively telomerase.
messages: nucleolus

367110:NCU02680
gene id: 367110:NCU02680
uniprot id: Q7SH49
uniprot id: V5IPA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPL4 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity).
messages: Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway.
messages: Membrane
messages: Nucleus membrane
messages: perinuclear region

367110:NCU04448
gene id: 367110:NCU04448
uniprot id: Q7RWB8
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

367110:NCU08726
gene id: 367110:NCU08726
uniprot id: O13360
names: Developmental Stage
names: Function
names: Subcellular Location Annotation
messages: Levels are detected just prior to the developmental commitment to budding growth.
messages: Nucleus
messages: Required for conidiophore morphogenesis where it has a role in the budding phase.

367110:NCU01525
gene id: 367110:NCU01525
uniprot id: Q7RY64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

367110:NCU04676
gene id: 367110:NCU04676
uniprot id: Q1K6E9
names: Similarity
messages: Belongs to the GST superfamily.

367110:NCU05810
gene id: 367110:NCU05810
uniprot id: Q01369
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). Required to activate general amino acid control under conditions of amino acid limitation in the vegetative growth phase, and for formation of protoperithecia in preparation for the sexual phase of the life cycle of N.crassa (PubMed:7651339).
messages: Component of the small ribosomal subunit (SSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Cytoplasm

367110:NCU08326
gene id: 367110:NCU08326
uniprot id: Q7SA63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

367110:NCU03957
gene id: 367110:NCU03957
uniprot id: Q7RZB1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Mitochondrion inner membrane

367110:NCU00916
gene id: 367110:NCU00916
uniprot id: V5IPZ3
uniprot id: V5IQD9
uniprot id: V5IRP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Membrane

367110:NCU03749
gene id: 367110:NCU03749
uniprot id: V5IL53
names: Function
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

367110:NCU07668
gene id: 367110:NCU07668
uniprot id: Q7S9N2
names: Subcellular Location Annotation
messages: Membrane

367110:NCU08746
gene id: 367110:NCU08746
uniprot id: Q7SCE9
names: Biotechnology
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide monooxygenase AA13 family.
messages: Binds 1 copper ion per subunit.
messages: Secreted
messages: Starch-active PMOs provide an expanded perspective on studies of starch metabolism and may have potential in the food and starch-based biofuel industries.
messages: Starch-active lytic polysaccharide monooxygenase that oxidizes the C1 position of starch substrates, but not in cellulose or chitin.
messages: The CBM20 domain is involved in binding to starch.

367110:NCU00585
gene id: 367110:NCU00585
uniprot id: P37295
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and from lycopene to beta-carotene via the intermediate gamma-carotene and from 3,4-didehydrolycopene to torulene (lycopene cyclase). Torulene is further processed to the acidic carotenoid neurosporaxanthin. The cyclase preferentially catalyzes single cyclizations at only one end of the substrate to produce monocyclic carotenoids (PubMed:11862485, PubMed:16928467). Neurosporaxanthin is synthesized from geranyl-geranyl pyrophosphate (GGPP) through several enzymatic activities. Phytoene synthase activity performed by the bifunctional enzyme al-2 first produces phytoene from geranyl-geranyl pyrophosphate (GGPP). The phytoene dehydrogenase al-1 then introduces 5 desaturations to lead to 3,4-didehydrolycopene via the intermediates phytofluene, zeta-carotene, neurosporene and lycopene. Al-2 cyclase activity then converts 3,4-didehydrolycopene into torulene. Al-2 can also convet lycopene into gamma-carotene which in turn is converted to beta-carotene by an additional al-2 cyclization reaction. Torulene is the substrate of the dioxidase cao-2 that breaks the molecule, removing five carbon atoms to yield beta-apo-4'-carotenal, whereas the aldehyde dehydrogenase ylo-1 mediates the last step by converting beta-apo-4'-carotenal into neurosporaxanthin (Probable).
messages: By blue light.
messages: In the C-terminal section; belongs to the phytoene/squalene synthase family.
messages: In the N-terminal section; belongs to the lycopene beta-cyclase family.
messages: Membrane

367110:NCU02410
gene id: 367110:NCU02410
uniprot id: V5IKE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS1 family.
messages: spindle

367110:NCU08697
gene id: 367110:NCU08697
uniprot id: Q7SCG8
names: Subcellular Location Annotation
messages: Membrane

367110:NCU04418
gene id: 367110:NCU04418
uniprot id: Q7RZ56
names: Subcellular Location Annotation
messages: Membrane

367110:NCU02840
gene id: 367110:NCU02840
uniprot id: Q7SDQ8
names: Similarity
messages: Belongs to the AAA ATPase family.

367110:NCU02100
gene id: 367110:NCU02100
uniprot id: Q7SDN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIMR family. LMBRD1 subfamily.
messages: Lysosome membrane
messages: Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors (By similarity).

367110:NCU09203
gene id: 367110:NCU09203
uniprot id: Q870S2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IWS1 family.
messages: Nucleus
messages: Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription (By similarity).

367110:NCU08618
gene id: 367110:NCU08618
uniprot id: Q7SFK1
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

367110:NCU06166
gene id: 367110:NCU06166
uniprot id: Q7S5C2
names: Similarity
messages: Belongs to the glycosyltransferase 15 family.

367110:NCU01234
gene id: 367110:NCU01234
uniprot id: Q9P735
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity).
messages: Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

367110:NCU03926
gene id: 367110:NCU03926
uniprot id: Q1K5Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS35 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Mitochondrion

367110:NCU00214
gene id: 367110:NCU00214
uniprot id: Q7RXL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU05961
gene id: 367110:NCU05961
uniprot id: Q7S1W0
names: Similarity
messages: Belongs to the CWC16 family.

367110:NCU09435
gene id: 367110:NCU09435
uniprot id: Q7S1Y0
names: Function
names: Subcellular Location Annotation
messages: Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
messages: Cytoplasm
messages: Nucleus

367110:NCU10061
gene id: 367110:NCU10061
uniprot id: Q7S051
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus

367110:NCU06614
gene id: 367110:NCU06614
uniprot id: Q7S9Q1
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU05582
gene id: 367110:NCU05582
uniprot id: Q7S6Y1
names: Similarity
messages: Belongs to the UFD1 family.

367110:NCU02650
gene id: 367110:NCU02650
uniprot id: Q7SH78
names: Similarity
messages: Belongs to the proteasome subunit p55 family.

367110:NCU04581
gene id: 367110:NCU04581
uniprot id: Q1K656
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

367110:NCU00951
gene id: 367110:NCU00951
uniprot id: Q6MVH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPase family.
messages: Cytoplasm

367110:NCU02746
gene id: 367110:NCU02746
uniprot id: Q7SGA4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

367110:NCU02538
gene id: 367110:NCU02538
uniprot id: Q7SHS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

367110:NCU06992
gene id: 367110:NCU06992
uniprot id: Q7SAF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.
messages: Belongs to the NSE1 family.
messages: Component of the Smc5-Smc6 complex.
messages: Nucleus

367110:NCU01962
gene id: 367110:NCU01962
uniprot id: V5IP40
uniprot id: V5IRD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 11 subunits. The complex is composed of a catalytic core of 3 subunits Cox1, Cox2 and Cox3, encoded in the mitochondrial DNA, and 8 supernumerary subunits Cox4, Cox5a/Cox5, Cox6, Cox7, Cox8, Cox7a/Cox9, Cox6b/Cox12 and Cox6a/Cox13, which are encoded in the nuclear genome (PubMed:31316820). The complex exists as a monomer or a dimer and forms respiratory supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in various different assemblies (supercomplexes I(1)IV(1), I(1)III(3)IV(2), III(2)IV(1) and III(2)IV(2) as well as larger supercomplexes of compositions like I(1)III(2)IV(5-6)) (PubMed:17873079). Cox6a/Cox13 was not present in the cryo-EM structure. It may be involved in complex IV dimer formation and might not be always expressed. This would explain its absence in the map of the isolated monomer (Probable).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of Cox2 and heme A of Cox1 to the active site in Cox1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

367110:NCU08395
gene id: 367110:NCU08395
uniprot id: V5IMB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.
messages: Nucleus

367110:NCU03254
gene id: 367110:NCU03254
uniprot id: Q7SEH3
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

367110:NCU06553
gene id: 367110:NCU06553
uniprot id: Q1K8F3
names: Similarity
messages: Belongs to the EIF1AD family.

367110:NCU06409
gene id: 367110:NCU06409
uniprot id: Q7RWE9
names: Similarity
messages: Belongs to the KRI1 family.

367110:NCU02956
gene id: 367110:NCU02956
uniprot id: Q7SH13
names: Similarity
messages: Belongs to the peptidase A1 family.

367110:NCU07807
gene id: 367110:NCU07807
uniprot id: P53444
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
messages: Homodimer.

367110:NCU02979
gene id: 367110:NCU02979
uniprot id: F5HH09
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

367110:NCU07964
gene id: 367110:NCU07964
uniprot id: Q7S921
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU06314
gene id: 367110:NCU06314
uniprot id: Q7SAB7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.
messages: May lack the polyribonucleotide 5'-hydroxyl-kinase and polynucleotide 5'-hydroxyl-kinase activities that are characteristic of the human ortholog.
messages: Nucleus
messages: Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.

367110:NCU06107
gene id: 367110:NCU06107
uniprot id: Q7S5I0
names: Similarity
messages: Belongs to the BolA/IbaG family.

367110:NCU08317
gene id: 367110:NCU08317
uniprot id: Q7SA71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC4 family.
messages: Nucleus

367110:NCU06062
gene id: 367110:NCU06062
uniprot id: Q7S4Y8
names: Similarity
messages: Belongs to the lysine N-acyltransferase MbtK family.

367110:NCU08767
gene id: 367110:NCU08767
uniprot id: F5HB11
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

367110:NCU01830
gene id: 367110:NCU01830
uniprot id: Q872T7
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

367110:NCU06781
gene id: 367110:NCU06781
uniprot id: Q1K8Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.

367110:NCU04035
gene id: 367110:NCU04035
uniprot id: Q7RZI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

367110:NCU08111
gene id: 367110:NCU08111
uniprot id: Q7SCW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.

367110:NCU08887
gene id: 367110:NCU08887
uniprot id: Q1K6A3
names: Subcellular Location Annotation
messages: Membrane

367110:NCU05248
gene id: 367110:NCU05248
uniprot id: Q7S8T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM41 family.
messages: Mitochondrion

367110:NCU02785
gene id: 367110:NCU02785
uniprot id: P80576
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the class-II DAHP synthase family.
messages: Homodimer.
messages: The N-terminus is blocked.

367110:NCU02450
gene id: 367110:NCU02450
uniprot id: V5IKE2
uniprot id: V5IKK2
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

367110:NCU03332
gene id: 367110:NCU03332
uniprot id: Q1K4P7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

367110:NCU02009
gene id: 367110:NCU02009
uniprot id: Q7SFM3
names: Subcellular Location Annotation
messages: Membrane

367110:NCU05385
gene id: 367110:NCU05385
uniprot id: Q1K8H7
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

367110:NCU02054
gene id: 367110:NCU02054
uniprot id: Q7SDE4
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU05956
gene id: 367110:NCU05956
uniprot id: Q7S1W5
names: Similarity
messages: Belongs to the glycosyl hydrolase 2 family.

367110:NCU11307
gene id: 367110:NCU11307
uniprot id: A7UWP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCC1 family.
messages: Membrane

367110:NCU03637
gene id: 367110:NCU03637
uniprot id: Q7RVV7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Proteolytically removes the C-terminal three residues of farnesylated proteins.

367110:NCU05410
gene id: 367110:NCU05410
uniprot id: Q9P3I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion matrix

367110:NCU04067
gene id: 367110:NCU04067
uniprot id: Q7RZF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAR5 family.
messages: Endoplasmic reticulum membrane
messages: Nucleus membrane
messages: Required for nuclear membrane fusion during karyogamy.

367110:NCU02010
gene id: 367110:NCU02010
uniprot id: Q7SFM2
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.

367110:NCU16378
gene id: 367110:NCU16378
uniprot id: V5IPD5
names: Function
names: Similarity
messages: Belongs to the CMC4 family.
messages: Required for the assembly of cytochrome c oxidase.

367110:NCU00089
gene id: 367110:NCU00089
uniprot id: U9WGN3
names: Function
names: Similarity
messages: Belongs to the MUB1/samB family.
messages: Involved in determination of the onset of polarized growth and morphogenesis. Plays a role in the regulation of branching in hyphae and spore formation.

367110:NCU00994
gene id: 367110:NCU00994
uniprot id: Q7SD30
names: Similarity
messages: Belongs to the peptidase A1 family.

367110:NCU09132
gene id: 367110:NCU09132
uniprot id: P38668
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

367110:NCU06254
gene id: 367110:NCU06254
uniprot id: U9W4N5
uniprot id: U9W863
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.

367110:NCU08898
gene id: 367110:NCU08898
uniprot id: Q870W1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.
messages: Mitochondrion

367110:NCU01735
gene id: 367110:NCU01735
uniprot id: V5IPH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal/bacterial/fungal opsin family.
messages: Membrane

367110:NCU03080
gene id: 367110:NCU03080
uniprot id: Q7SDT0
names: Subcellular Location Annotation
messages: Membrane

367110:NCU01102
gene id: 367110:NCU01102
uniprot id: Q7RVX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

367110:NCU05268
gene id: 367110:NCU05268
uniprot id: Q7S857
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.

367110:NCU02476
gene id: 367110:NCU02476
uniprot id: Q7SG88
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

367110:NCU07358
gene id: 367110:NCU07358
uniprot id: Q7S0Q1
names: Subcellular Location Annotation
messages: Nucleus

367110:NCU08046
gene id: 367110:NCU08046
uniprot id: Q6MFP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit G family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.

367110:NCU07691
gene id: 367110:NCU07691
uniprot id: Q7S828
names: Similarity
messages: Belongs to the putative lipase ROG1 family.

367110:NCU06483
gene id: 367110:NCU06483
uniprot id: Q7RYJ1
names: Similarity
messages: Belongs to the WD repeat MET30/SCONB/SCON-2 family.

367110:NCU01670
gene id: 367110:NCU01670
uniprot id: Q9P6B0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YPI1 family.
messages: Nucleus
messages: Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.

367110:NCU08066
gene id: 367110:NCU08066
uniprot id: Q7SGL7
names: Similarity
messages: Belongs to the amino acid/polyamine transporter 2 family.

367110:NCU02906
gene id: 367110:NCU02906
uniprot id: Q7SHJ8
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

367110:NCU08730
gene id: 367110:NCU08730
uniprot id: Q9C291
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Forms a complex with RAD50.
messages: Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing (By similarity).
messages: Nucleus

367110:NCU06631
gene id: 367110:NCU06631
uniprot id: Q7S8B6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EXO84 family.
messages: Component of the exocyst complex.
messages: Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome (By similarity).
messages: secretory vesicle

367110:NCU01907
gene id: 367110:NCU01907
uniprot id: Q7SH99
names: Similarity
messages: Belongs to the syntaxin family.

367110:NCU02260
gene id: 367110:NCU02260
uniprot id: Q7RVB2
names: Similarity
messages: Belongs to the AAA ATPase family.

367110:NCU01737
gene id: 367110:NCU01737
uniprot id: F5HG24
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

367110:NCU01317
gene id: 367110:NCU01317
uniprot id: Q9C285
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Component of the large ribosomal subunit (LSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

367110:NCU06561
gene id: 367110:NCU06561
uniprot id: Q7RVX7
names: Similarity
messages: Belongs to the Rho GDI family.

367110:NCU03954
gene id: 367110:NCU03954
uniprot id: P53377
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.
messages: spindle pole body

367110:NCU02675
gene id: 367110:NCU02675
uniprot id: Q7SH54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: nucleolus

367110:NCU09175
gene id: 367110:NCU09175
uniprot id: Q7S340
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 17 family.
messages: cell wall

367110:NCU04784
gene id: 367110:NCU04784
uniprot id: Q7S6Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin GLFG family.
messages: nuclear pore complex

367110:NCU03006
gene id: 367110:NCU03006
uniprot id: Q9P3R1
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.
messages: Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of lanosterol to form eburicol.
messages: In Neurospora, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Neurospora, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.

367110:NCU02423
gene id: 367110:NCU02423
uniprot id: Q7S4D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

367110:NCU08760
gene id: 367110:NCU08760
uniprot id: Q7RWN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 61 family.
messages: Secreted

367110:NCU08794
gene id: 367110:NCU08794
uniprot id: Q7RWX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

367110:NCU05045
gene id: 367110:NCU05045
uniprot id: Q7RX43
names: Subcellular Location Annotation
messages: Membrane

367110:NCU05944
gene id: 367110:NCU05944
uniprot id: Q7S2D4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
messages: Component of the Mediator complex.
messages: Nucleus

367110:NCU06729
gene id: 367110:NCU06729
uniprot id: Q05424
names: Function
names: Similarity
names: Subunit
messages: Belongs to the G-alpha family. G(q) subfamily.
messages: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

367110:NCU09565
gene id: 367110:NCU09565
uniprot id: Q7S429
names: Similarity
messages: Belongs to the cytochrome P450 family.

367110:NCU02208
gene id: 367110:NCU02208
uniprot id: Q7S464
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit B family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

367110:NCU02917
gene id: 367110:NCU02917
uniprot id: Q7SHI7
names: Caution
names: Function
names: Induction
names: Similarity
messages: A recent genetics report associated srdA and its cluster with the biosynthesis of furanocoumarin neurosporin A, a metabolite produced by N.crassa for chemoresistance against predation by arthropod fungivores (PubMed:28485098). However, based on the gene cluster organization and predicted gene functions, this cluster is unlikely to be involved in neurosporin A biosynthesis, but instead produces compounds similar to pyriculol (PubMed:30908040).
messages: Belongs to the methyltransferase superfamily.
messages: Expression is up-regulated during sexual development (PubMed:19277664). Expression is also up-regulated during confrontation with the arthropod fungivore Drosophila melanogaster (PubMed:28485098).
messages: Methyltransferase; part of the gene cluster that mediates the biosynthesis of sordarial, a salicylic aldehyde structurally related to the phytotoxin pyriculol (PubMed:19277664, PubMed:28485098, PubMed:30908040). The most interesting aspect of this pathway is formation of an aromatic product from the highly reducing polyketide synthase srdA (PubMed:30908040). SrdA synthesizes a reduced polyketide chain from one molecule of acetyl-CoA and five molecules of malonyl-CoA (PubMed:30908040). The polyketide chain is then reductively released as an aldehyde (PubMed:30908040). The oxidoreductases srdC, srdD and srdE then oxidize one of the hydroxy groups to facilitate the intramolecular aldol condensation, followed by dehydration to yield a salicylic aldehyde (PubMed:30908040). This aldehyde can undergo facile reduction by endogenous reductases to yield the alcohol 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene (PubMed:30908040). The flavin-dependent srdI counteract against the propensity of the aldehydes to be reduced under physiological conditions and is responsible for reoxidizing 1-hydroxy-2-hydroxymethyl-3-pent-1,3-dienylbenzene back to the salicylic aldehyde (PubMed:30908040). This salicylic aldehyde is then selectively epoxidized by the cupin-domain-containing oxidoreductase srdB to yield the epoxide, which can be hydrolyzed stereoselectively by the hydrolase srdG to give the final product sordarial (PubMed:30908040).

367110:NCU08192
gene id: 367110:NCU08192
uniprot id: Q7S3P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cerato-ulmin hydrophobin family.
messages: cell wall

367110:NCU01740
gene id: 367110:NCU01740
uniprot id: Q9P534
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CHZ1 family.
messages: Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.
messages: Forms a heterotrimer with H2A.Z-H2B, stabilizing the association of the histone dimer. Also, with a lower affinity, forms a heterotrimer with H2A-H2B (By similarity).
messages: Nucleus

367110:NCU05558
gene id: 367110:NCU05558
uniprot id: Q7S705
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

367110:NCU07124
gene id: 367110:NCU07124
uniprot id: Q7S6C8
names: Similarity
messages: Belongs to the terpene synthase family.

367110:NCU07844
gene id: 367110:NCU07844
uniprot id: Q7SBW4
names: Similarity
messages: Belongs to the AAR2 family.

367110:NCU16845
gene id: 367110:NCU16845
uniprot id: Q7SA35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Endoplasmic reticulum membrane

367110:NCU07975
gene id: 367110:NCU07975
uniprot id: Q7SAR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

367110:NCU07420
gene id: 367110:NCU07420
uniprot id: Q7RV88
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G (By similarity).
messages: Cytoplasm
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

367110:NCU04662
gene id: 367110:NCU04662
uniprot id: Q872C6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated to atg12; which is essential for autophagy.
messages: Conjugated with atg12.
messages: Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with atg12, through a ubiquitin-like conjugating system involving apg-5/atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-apg-4/atg5 conjugate acts as an E3-like enzyme which is required for lipidation of apg-6/atg8 and apg-6/atg8 association to the vesicle membranes (By similarity).
messages: Preautophagosomal structure membrane

367110:NCU02554
gene id: 367110:NCU02554
uniprot id: Q7SHR1
names: Similarity
messages: Belongs to the VPS8 family.

367110:NCU11381
gene id: 367110:NCU11381
uniprot id: A7UX64
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.

367110:NCU03935
gene id: 367110:NCU03935
uniprot id: Q7RZC2
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

367110:NCU08005
gene id: 367110:NCU08005
uniprot id: Q7SAN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferredoxin--NADP reductase type 1 family.
messages: Mitochondrion

367110:NCU04264
gene id: 367110:NCU04264
uniprot id: Q1K7I3
names: Similarity
messages: Belongs to the glutamine synthetase family.

367110:NCU09156
gene id: 367110:NCU09156
uniprot id: U9W4F6
uniprot id: U9W7Y2
names: Subcellular Location Annotation
messages: Membrane

367110:NCU01945
gene id: 367110:NCU01945
uniprot id: Q7SDZ1
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Allosterically activated by ATP (By similarity). ATP binding is a prerequisite to magnesium and substrate binding. ATP binds to 2 of the subunits in the homotetramer inducing a closure of these 2 subunits and the release of the C-terminal loop, thereby activating the enzyme (By similarity).
messages: Belongs to the ISN1 family.
messages: Homotetramer.
messages: IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation.

367110:NCU08963
gene id: 367110:NCU08963
uniprot id: Q7S7F1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL30 family.
messages: Component of the large ribosomal subunit (LSU). Mature N.crassa ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and at least 32 different proteins. The large 60S subunit contains 3 rRNA molecules (26S, 5.8S and 5S rRNA) and at least 42 different proteins.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
messages: Cytoplasm

367110:NCU16966
gene id: 367110:NCU16966
uniprot id: V5IM18
names: Similarity
messages: Belongs to the HSBP1 family.

367110:NCU09799
gene id: 367110:NCU09799
uniprot id: Q7S5S2
names: Subcellular Location Annotation
messages: Membrane

367110:NCU16972
gene id: 367110:NCU16972
uniprot id: V5IM67
names: Similarity
messages: Belongs to the DCP1 family.

367110:NCU04280
gene id: 367110:NCU04280
uniprot id: Q1K789
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Mitochondrion

367110:NCU04385
gene id: 367110:NCU04385
uniprot id: Q7RZ87
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

367110:NCU04127
gene id: 367110:NCU04127
uniprot id: Q9C2D4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.
messages: Necessary for protein translocation in the endoplasmic reticulum.

367110:NCU01794
gene id: 367110:NCU01794
uniprot id: Q1K553
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OST4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU08748
gene id: 367110:NCU08748
uniprot id: Q7SCE7
names: Subcellular Location Annotation
messages: Membrane

367110:NCU05391
gene id: 367110:NCU05391
uniprot id: Q1K8S3
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

367110:NCU02113
gene id: 367110:NCU02113
uniprot id: Q7SDM1
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

367110:NCU07447
gene id: 367110:NCU07447
uniprot id: Q7SF08
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06382
gene id: 367110:NCU06382
uniprot id: Q7S9G5
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06089
gene id: 367110:NCU06089
uniprot id: Q7S483
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
messages: Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Nucleus

367110:NCU01515
gene id: 367110:NCU01515
uniprot id: Q1K5K1
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

367110:NCU09420
gene id: 367110:NCU09420
uniprot id: Q7S0S7
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

367110:NCU03947
gene id: 367110:NCU03947
uniprot id: Q7RV01
names: Similarity
messages: Belongs to the RSP5/NEDD4 family.

367110:NCU05077
gene id: 367110:NCU05077
uniprot id: Q7RWK7
names: Subcellular Location Annotation
messages: Membrane

367110:NCU02850
gene id: 367110:NCU02850
uniprot id: Q7RV37
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

367110:NCU08840
gene id: 367110:NCU08840
uniprot id: Q7S8X5
names: Similarity
messages: Belongs to the actin family.

367110:NCU00824
gene id: 367110:NCU00824
uniprot id: Q7SEB0
names: Similarity
messages: Belongs to the histone deacetylase family. HD type 1 subfamily.

367110:NCU17284
gene id: 367110:NCU17284
uniprot id: V5IMX3
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

367110:NCU04740
gene id: 367110:NCU04740
uniprot id: Q7S6G6
names: Function
names: Subcellular Location Annotation
messages: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Nucleus

367110:NCU00290
gene id: 367110:NCU00290
uniprot id: Q7RZS4
names: Subcellular Location Annotation
messages: Membrane

367110:NCU06401
gene id: 367110:NCU06401
uniprot id: Q7S9E6
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

367110:NCU03855
gene id: 367110:NCU03855
uniprot id: V5IKZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
messages: Belongs to the CNOT2/3/5 family.
messages: Cytoplasm
messages: Nucleus

367110:NCU08696
gene id: 367110:NCU08696
uniprot id: Q7SCG9
names: Subcellular Location Annotation
messages: Membrane

367110:NCU02505
gene id: 367110:NCU02505
uniprot id: Q7SHV6
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
messages: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

367110:NCU08176
gene id: 367110:NCU08176
uniprot id: Q7S4B7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polysaccharide lyase 3 family.
messages: Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.
messages: Secreted

367110:NCU03190
gene id: 367110:NCU03190
uniprot id: Q7SGX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

367110:NCU11320
gene id: 367110:NCU11320
uniprot id: A7UWS8
names: Similarity
messages: Belongs to the arginase family.

367110:NCU07701
gene id: 367110:NCU07701
uniprot id: Q7S9K5
names: Subcellular Location Annotation
messages: Membrane

367110:NCU10048
gene id: 367110:NCU10048
uniprot id: Q7S084
names: Function
names: Similarity
messages: Belongs to the PanB family.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.

367110:NCU03488
gene id: 367110:NCU03488
uniprot id: P05035
names: Similarity
messages: Belongs to the OMP decarboxylase family.

367110:NCU06424
gene id: 367110:NCU06424
uniprot id: Q7RYZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GcvT family. CAF17 subfamily.
messages: Mitochondrion

367110:NCU04407
gene id: 367110:NCU04407
uniprot id: Q7RZ67
names: Function
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.

367110:NCU00636
gene id: 367110:NCU00636
uniprot id: Q7SI16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase d subunit family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/atp6 static relative to the rotary elements (By similarity).
messages: Mitochondrion inner membrane

367110:NCU04724
gene id: 367110:NCU04724
uniprot id: Q7S6I0
names: Subunit
messages: Component of the ESCRT-0 complex composed of HSE1 and VPS27.

367110:NCU08325
gene id: 367110:NCU08325
uniprot id: Q7RVX9
names: Activity Regulation
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane
messages: High-affinity transporter for external inorganic phosphate. Acts probably as a H(+)-phosphate symporter.
messages: Impairs growth at low phosphate conditions when pho-4 is also absent.
messages: Phosphate transport activity is competitively inhibited by arsenate.
messages: Transcription is controlled by the phosphorus-acquisition regulatory system.

367110:NCU04072
gene id: 367110:NCU04072
uniprot id: Q7RZE7
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

367110:NCU00629
gene id: 367110:NCU00629
uniprot id: Q7SI23
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

367110:NCU04775
gene id: 367110:NCU04775
uniprot id: Q7S634
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.

367110:NCU00754
gene id: 367110:NCU00754
uniprot id: Q7SDR9
names: Subcellular Location Annotation
messages: Membrane

367110:NCU01195
gene id: 367110:NCU01195
uniprot id: P00369
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

367110:NCU09771
gene id: 367110:NCU09771
uniprot id: Q7S191
names: Subcellular Location Annotation
messages: Membrane

367110:NCU05502
gene id: 367110:NCU05502
uniprot id: Q7S6T7
names: Subcellular Location Annotation
messages: Membrane

367110:NCU01632
gene id: 367110:NCU01632
uniprot id: Q8X071
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: In the 2nd section; belongs to the EPSP synthase family.
messages: In the 3rd section; belongs to the shikimate kinase family.
messages: In the 4th section; belongs to the type-I 3-dehydroquinase family.
messages: In the C-terminal section; belongs to the shikimate dehydrogenase family.
messages: In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.

367110:NCU04342
gene id: 367110:NCU04342
uniprot id: Q7RX34
names: Similarity
messages: Belongs to the Gfa family.

367110:NCU01439
gene id: 367110:NCU01439
uniprot id: Q7RWH3
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

367110:NCU08783
gene id: 367110:NCU08783
uniprot id: Q7RWY0
names: Similarity
messages: Belongs to the peptidase S33 family.

367110:NCU09251
gene id: 367110:NCU09251
uniprot id: Q7SF59
names: Similarity
messages: Belongs to the TMEM14 family.

367110:NCU02830
gene id: 367110:NCU02830
uniprot id: Q7SCI6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: GTPase-activating protein for the ADP ribosylation factor family.

367110:NCU02948
gene id: 367110:NCU02948
uniprot id: Q7SHF6
names: Similarity
messages: Belongs to the WrbA family.

367110:NCU03008
gene id: 367110:NCU03008
uniprot id: Q9P3Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool (By similarity).
messages: Belongs to the complex I LYR family. MZM1 subfamily.
messages: Interacts with RIP1.
messages: Mitochondrion matrix

367110:NCU00202
gene id: 367110:NCU00202
uniprot id: Q7RXM4
names: Similarity
messages: Belongs to the WD repeat coronin family.

367110:NCU05522
gene id: 367110:NCU05522
uniprot id: Q7S6R7
names: Similarity
messages: Belongs to the thioesterase PaaI family.

367110:NCU04230
gene id: 367110:NCU04230
uniprot id: P28299
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
messages: By acetate.
messages: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2-methylisocitrate.
messages: Glyoxysome
messages: Homotetramer.

367110:NCU09239
gene id: 367110:NCU09239
uniprot id: Q7SF71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PCNA family.
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

367110:NCU09859
gene id: 367110:NCU09859
uniprot id: Q7S5Z5
names: Function
names: Similarity
messages: Belongs to the peptidase M43B family.
messages: Secreted metalloproteinase that allows assimilation of proteinaceous substrates.

367110:NCU00147
gene id: 367110:NCU00147
uniprot id: Q7RXR1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
messages: Cytoplasm
messages: Nucleus

367110:NCU07325
gene id: 367110:NCU07325
uniprot id: P10713
names: Developmental Stage
names: Similarity
messages: Belongs to the con-10 family.
messages: Expressed during the late stage of conidial (dormant spores) differentiation. It is greatly reduced or absent in the aconidial mutants fd, acon-2 and acon-3.

367110:NCU08009
gene id: 367110:NCU08009
uniprot id: Q7SAN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

367110:NCU02007
gene id: 367110:NCU02007
uniprot id: Q7SFM5
names: Similarity
messages: Belongs to the complex I LYR family.

367110:NCU01612
gene id: 367110:NCU01612
uniprot id: Q1K557
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.

367110:NCU16370
gene id: 367110:NCU16370
uniprot id: V5IP97
names: Subcellular Location Annotation
messages: Membrane

367110:NCU10927
gene id: 367110:NCU10927
uniprot id: A7UWE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
messages: Cytoplasm
messages: nucleolus

367110:NCU02358
gene id: 367110:NCU02358
uniprot id: Q7S4W8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDS23 family.
messages: Cytoplasm
messages: Involved in DNA replication and cell separation.

367110:NCU08290
gene id: 367110:NCU08290
uniprot id: Q7SA95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ku70 family.
messages: Heterodimer of mus-51/ku70 and mus-52/ku80.
messages: Nucleus
messages: Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching (By similarity).
messages: telomere

367110:NCU08218
gene id: 367110:NCU08218
uniprot id: Q7S3M5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
messages: Early endosome membrane
messages: Golgi apparatus membrane
messages: Palmitoyltransferase specific for casein kinase 1.
messages: The DHHC domain is required for palmitoyltransferase activity.

367110:NCU09184
gene id: 367110:NCU09184
uniprot id: U9W4G0
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

367110:NCU04281
gene id: 367110:NCU04281
uniprot id: Q1K788
names: Similarity
messages: Belongs to the WD repeat LST8 family.

367110:NCU01902
gene id: 367110:NCU01902
uniprot id: Q7SHA4
names: Similarity
messages: Belongs to the acetyltransferase family. GNA1 subfamily.

367110:NCU03492
gene id: 367110:NCU03492
uniprot id: Q7RW89
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family. SCS7 subfamily.
messages: Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.
messages: Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU03409
gene id: 367110:NCU03409
uniprot id: Q1K5F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lariat debranching enzyme family.
messages: Nucleus

367110:NCU08875
gene id: 367110:NCU08875
uniprot id: V5IKW9
names: Similarity
messages: Belongs to the CAND family.

367110:NCU09477
gene id: 367110:NCU09477
uniprot id: P02723
uniprot id: V5INM6
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Monomer.
messages: The matrix-open state (m-state) is inhibited by the membrane-permeable bongkrekic acid (BKA). The cytoplasmic-open state (c-state) is inhibited by the membrane-impermeable toxic inhibitor carboxyatractyloside (CATR).
messages: The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.

367110:NCU03039
gene id: 367110:NCU03039
uniprot id: Q7SDG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the splicing factor SR family.
messages: Necessary for the splicing of pre-mRNA.
messages: Nucleus

367110:NCU06675
gene id: 367110:NCU06675
uniprot id: Q1K6Y5
names: Similarity
messages: Belongs to the peptidase S33 family.

367110:NCU01301
gene id: 367110:NCU01301
uniprot id: Q9HEG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LOC1 family.
messages: Component of the 66S pre-ribosomal particle.
messages: Required for efficient assembly and nuclear export of the 60S ribosomal subunit.
messages: nucleolus

367110:NCU06632
gene id: 367110:NCU06632
uniprot id: P35848
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tom20 family.
messages: Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with tom22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore.
messages: Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 8 different proteins (tom5, tom6, tom7, tom20, tom22, tom37, tom40 and tom70).
messages: Mitochondrion outer membrane

367110:NCU09248
gene id: 367110:NCU09248
uniprot id: V5IQF3
uniprot id: V5IRI7
names: Similarity
messages: Belongs to the NFYB/HAP3 subunit family.

367110:NCU04378
gene id: 367110:NCU04378
uniprot id: Q7RZ94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus

367110:NCU06112
gene id: 367110:NCU06112
uniprot id: Q7S5H6
names: Similarity
messages: Belongs to the group II decarboxylase family.

367110:NCU07869
gene id: 367110:NCU07869
uniprot id: Q7SBU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

367110:NCU09121
gene id: 367110:NCU09121
uniprot id: Q7S2M7
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

367110:NCU05714
gene id: 367110:NCU05714
uniprot id: Q7SB98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature N.crassa 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 16S ribosomal RNA (16S mt-rRNA) and 32 different proteins. The 54S large subunit contains a 23S rRNA (23S mt-rRNA) and 42 different proteins.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

367110:NCU09709
gene id: 367110:NCU09709
uniprot id: Q7S2R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

367110:NCU07985
gene id: 367110:NCU07985
uniprot id: Q7SAQ4
names: Subcellular Location Annotation
messages: Membrane

367110:NCU00969
gene id: 367110:NCU00969
uniprot id: P42116
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Complex I is composed of about 40 different subunits.
messages: Mitochondrion inner membrane
messages: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.