349967:HRD69 RS13590
gene id: 349967:HRD69_RS13590
uniprot id: A0A7D4PGA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS03540
gene id: 349967:HRD69_RS03540
uniprot id: A0A7D4P6N4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

349967:HRD69 RS13685
gene id: 349967:HRD69_RS13685
uniprot id: A0A7D4PS98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgI family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

349967:HRD69 RS09635
gene id: 349967:HRD69_RS09635
uniprot id: A0A7D4T260
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.

349967:HRD69 RS06595
gene id: 349967:HRD69_RS06595
uniprot id: A0A7D4SVU2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.

349967:HRD69 RS15690
gene id: 349967:HRD69_RS15690
uniprot id: A0A7D4U0K3
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

349967:HRD69 RS18035
gene id: 349967:HRD69_RS18035
uniprot id: A0A7D4P7B0
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS15420
gene id: 349967:HRD69_RS15420
uniprot id: A0A7D4SWW7
names: Similarity
messages: Belongs to the transposase 7 family.

349967:HRD69 RS14380
gene id: 349967:HRD69_RS14380
uniprot id: A0A7D4TP78
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport.

349967:HRD69 RS14915
gene id: 349967:HRD69_RS14915
uniprot id: A0A7D4P4J4
names: Similarity
messages: Belongs to the glucose-6-phosphate 1-epimerase family.

349967:HRD69 RS03885
gene id: 349967:HRD69_RS03885
uniprot id: A0A7D4T115
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiJ family.
messages: Cytoplasm
messages: Required for ubiquinone (coenzyme Q) biosynthesis. Binds hydrophobic ubiquinone biosynthetic intermediates via its SCP2 domain and is essential for the stability of the Ubi complex. May constitute a docking platform where Ubi enzymes assemble and access their SCP2-bound polyprenyl substrates.

349967:HRD69 RS17185
gene id: 349967:HRD69_RS17185
uniprot id: A0A7D4SXK3
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-90 and Arg-93) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-dependent lysine deacetylase that specifically removes acetyl groups on target proteins. Also acts as a protein-lysine deacylase by mediating protein desuccinylation and de-2-hydroxyisobutyrylation. Modulates the activities of several proteins which are inactive in their acylated form.

349967:HRD69 RS09090
gene id: 349967:HRD69_RS09090
uniprot id: A0A7D4T6J2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. FtsW subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell division.

349967:HRD69 RS19585
gene id: 349967:HRD69_RS19585
uniprot id: A0A7D4U332
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtC subfamily.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtC forms a heteromultimer with MdtB.

349967:HRD69 RS00325
gene id: 349967:HRD69_RS00325
uniprot id: A0A7D4PD48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

349967:HRD69 RS09390
gene id: 349967:HRD69_RS09390
uniprot id: A0A7D4PS11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DksA family.
messages: Cytoplasm
messages: Interacts directly with the RNA polymerase.
messages: Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression.

349967:HRD69 RS17675
gene id: 349967:HRD69_RS17675
uniprot id: A0A7D4U4T9
names: Similarity
messages: Belongs to the VgrG protein family.

349967:HRD69 RS10775
gene id: 349967:HRD69_RS10775
uniprot id: A0A7D4P8B2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

349967:HRD69 RS08260
gene id: 349967:HRD69_RS08260
uniprot id: A0A7D4P7P3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RraB family.
messages: Cytoplasm
messages: Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.
messages: Interacts with the C-terminal region of Rne.

349967:HRD69 RS16610
gene id: 349967:HRD69_RS16610
uniprot id: A0A7D4PTI5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS01060
gene id: 349967:HRD69_RS01060
uniprot id: A0A7D4P391
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase Slt family.
messages: Cell outer membrane
messages: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division.

349967:HRD69 RS18220
gene id: 349967:HRD69_RS18220
uniprot id: A0A7D4U2S0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein PotD/PotF family.
messages: Periplasm
messages: Required for the activity of the bacterial periplasmic transport system of putrescine.

349967:HRD69 RS15500
gene id: 349967:HRD69_RS15500
uniprot id: A0A7D4P4M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
messages: Cell inner membrane

349967:HRD69 RS14685
gene id: 349967:HRD69_RS14685
uniprot id: A0A7D4PT39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

349967:HRD69 RS05150
gene id: 349967:HRD69_RS05150
uniprot id: A0A7D4TJ37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

349967:HRD69 RS00085
gene id: 349967:HRD69_RS00085
uniprot id: A0A7D4STX2
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

349967:HRD69 RS19535
gene id: 349967:HRD69_RS19535
uniprot id: A0A7D4SXZ3
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS04150
gene id: 349967:HRD69_RS04150
uniprot id: A0A7D4P9N6
names: Similarity
messages: Belongs to the Rht family.

349967:HRD69 RS12385
gene id: 349967:HRD69_RS12385
uniprot id: A0A7D4SWS1
names: Similarity
messages: Belongs to the MoaD family.

349967:HRD69 RS19785
gene id: 349967:HRD69_RS19785
uniprot id: A0A7D4U599
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

349967:HRD69 RS03310
gene id: 349967:HRD69_RS03310
uniprot id: A0A7D4P0V5
names: Subcellular Location Annotation
messages: Cytoplasm

349967:HRD69 RS17975
gene id: 349967:HRD69_RS17975
uniprot id: A0A7D4PAN7
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS06330
gene id: 349967:HRD69_RS06330
uniprot id: A0A7D4TZZ9
names: Function
names: Similarity
messages: Belongs to the IolE/MocC family.
messages: Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol).

349967:HRD69 RS01055
gene id: 349967:HRD69_RS01055
uniprot id: A0A7D4P665
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Fe(2+)-trafficking protein family.
messages: Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
messages: Monomer.

349967:HRD69 RS16015
gene id: 349967:HRD69_RS16015
uniprot id: A0A7D4TLV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm

349967:HRD69 RS05050
gene id: 349967:HRD69_RS05050
uniprot id: A0A7D4U1G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS04055
gene id: 349967:HRD69_RS04055
uniprot id: A0A7D4P6R2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.

349967:HRD69 RS10105
gene id: 349967:HRD69_RS10105
uniprot id: A0A7D4PFL0
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

349967:HRD69 RS01810
gene id: 349967:HRD69_RS01810
uniprot id: A0A7D4TES9
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

349967:HRD69 RS15735
gene id: 349967:HRD69_RS15735
uniprot id: A0A7D4PSS6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArsB family.
messages: Cell membrane
messages: Involved in arsenical resistance. Thought to form the channel of an arsenite pump.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

349967:HRD69 RS11665
gene id: 349967:HRD69_RS11665
uniprot id: A0A7D4P2Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpoB family.
messages: Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division.
messages: Periplasm

349967:HRD69 RS03810
gene id: 349967:HRD69_RS03810
uniprot id: A0A7D4U0X4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HemG family.
messages: Belongs to the flavodoxin family.
messages: Binds 1 FMN non-covalently per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX; under anaerobic conditions uses menaquinone as an electron acceptor, under aerobic conditions uses ubiquinone as an electron acceptor.
messages: Cell membrane

349967:HRD69 RS12825
gene id: 349967:HRD69_RS12825
uniprot id: A0A7D4SWE8
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS19505
gene id: 349967:HRD69_RS19505
uniprot id: A0A7D4P7Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS05210
gene id: 349967:HRD69_RS05210
uniprot id: A0A7D4PQY3
names: Similarity
messages: Belongs to the ner transcriptional regulatory family.

349967:HRD69 RS04970
gene id: 349967:HRD69_RS04970
uniprot id: A0A7D4P408
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

349967:HRD69 RS12945
gene id: 349967:HRD69_RS12945
uniprot id: A0A7D4T7C1
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

349967:HRD69 RS00720
gene id: 349967:HRD69_RS00720
uniprot id: A0A7D4P8T1
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

349967:HRD69 RS12580
gene id: 349967:HRD69_RS12580
uniprot id: A0A7D4PRZ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Gram-negative porin family.
messages: Cell outer membrane
messages: Homotrimer.
messages: Membrane

349967:HRD69 RS08865
gene id: 349967:HRD69_RS08865
uniprot id: A0A7D4TMS7
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

349967:HRD69 RS17070
gene id: 349967:HRD69_RS17070
uniprot id: A0A7D4PTU6
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS11805
gene id: 349967:HRD69_RS11805
uniprot id: A0A7D4PC16
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

349967:HRD69 RS04035
gene id: 349967:HRD69_RS04035
uniprot id: A0A7D4TZB8
names: Similarity
messages: Belongs to the leucine-binding protein family.

349967:HRD69 RS07790
gene id: 349967:HRD69_RS07790
uniprot id: A0A7D4TYA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm
messages: Monomer.

349967:HRD69 RS12210
gene id: 349967:HRD69_RS12210
uniprot id: A0A7D4TZE2
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

349967:HRD69 RS01720
gene id: 349967:HRD69_RS01720
uniprot id: A0A7D4U066
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

349967:HRD69 RS20185
gene id: 349967:HRD69_RS20185
uniprot id: A0A7D4T8T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RseB family.
messages: Periplasm

349967:HRD69 RS10760
gene id: 349967:HRD69_RS10760
uniprot id: A0A7D4P2H8
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

349967:HRD69 RS10185
gene id: 349967:HRD69_RS10185
uniprot id: A0A7D4T6S2
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

349967:HRD69 RS10675
gene id: 349967:HRD69_RS10675
uniprot id: A0A7D4PRB0
names: Function
names: Similarity
messages: A cysteine desulfhydrase that generates hydrogen sulfide, H(2)S. The H(2)S produced by this enzyme may modulate central metabolism.
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family. Cds1 subfamily.

349967:HRD69 RS07665
gene id: 349967:HRD69_RS07665
uniprot id: A0A7D4TJV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FrdD family.
messages: Cell membrane
messages: Part of an enzyme complex containing four subunits: a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD).
messages: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth. Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones.

349967:HRD69 RS08130
gene id: 349967:HRD69_RS08130
uniprot id: A0A7D4U0E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.
messages: Catalyzes both the uptake and excretion of putrescine. The uptake of putrescine is dependent on the membrane potential and the excretion involves putrescine-ornithine antiporter activity.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS20445
gene id: 349967:HRD69_RS20445
uniprot id: A0A7D4TJE6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

349967:HRD69 RS03470
gene id: 349967:HRD69_RS03470
uniprot id: A0A7D4PPG3
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

349967:HRD69 RS11305
gene id: 349967:HRD69_RS11305
uniprot id: A0A7D4PAY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS08415
gene id: 349967:HRD69_RS08415
uniprot id: A0A7D4SW55
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS19460
gene id: 349967:HRD69_RS19460
uniprot id: A0A7D4TMZ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48 family. BepA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state.
messages: Periplasm

349967:HRD69 RS01725
gene id: 349967:HRD69_RS01725
uniprot id: A0A7D4TYQ3
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

349967:HRD69 RS16425
gene id: 349967:HRD69_RS16425
uniprot id: A0A7D4T7Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Vitamin B12 importer (TC 3.A.1.13.1) family.
messages: Cell membrane
messages: Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (BtuD), two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).

349967:HRD69 RS04880
gene id: 349967:HRD69_RS04880
uniprot id: A0A7D4P5P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CpxP/Spy family.
messages: Periplasm

349967:HRD69 RS05915
gene id: 349967:HRD69_RS05915
uniprot id: A0A7D4PA75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyltransferase 3 family.
messages: Cell inner membrane
messages: Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units.

349967:HRD69 RS19455
gene id: 349967:HRD69_RS19455
uniprot id: A0A7D4TJ70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

349967:HRD69 RS09895
gene id: 349967:HRD69_RS09895
uniprot id: A0A7D4T6Q3
names: Subcellular Location Annotation
messages: Cytoplasm

349967:HRD69 RS12030
gene id: 349967:HRD69_RS12030
uniprot id: A0A7D4PC33
names: Similarity
messages: Belongs to the CinA family.

349967:HRD69 RS16565
gene id: 349967:HRD69_RS16565
uniprot id: A0A7D4U2D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M23B family.
messages: Membrane

349967:HRD69 RS06715
gene id: 349967:HRD69_RS06715
uniprot id: A0A7D4SV64
names: Similarity
messages: Belongs to the phosphoribulokinase family.

349967:HRD69 RS11350
gene id: 349967:HRD69_RS11350
uniprot id: A0A7D4PUU5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

349967:HRD69 RS15860
gene id: 349967:HRD69_RS15860
uniprot id: A0A7D4PGV6
names: Function
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

349967:HRD69 RS00880
gene id: 349967:HRD69_RS00880
uniprot id: A0A7D4PJR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LysE/ArgO transporter (TC 2.A.75) family.
messages: Cell membrane
messages: Involved in the export of arginine. Important to control the intracellular level of arginine and the correct balance between arginine and lysine.
messages: Membrane

349967:HRD69 RS06795
gene id: 349967:HRD69_RS06795
uniprot id: A0A7D4P4K5
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

349967:HRD69 RS08720
gene id: 349967:HRD69_RS08720
uniprot id: A0A7D4PRX4
names: Caution
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. GpmB subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS13870
gene id: 349967:HRD69_RS13870
uniprot id: A0A7D4PBJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

349967:HRD69 RS08115
gene id: 349967:HRD69_RS08115
uniprot id: A0A7D4TYD5
names: Function
names: Similarity
messages: Belongs to the UbiT family.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Likely functions as an accessory factor.

349967:HRD69 RS14410
gene id: 349967:HRD69_RS14410
uniprot id: A0A7D4U3Y4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

349967:HRD69 RS14625
gene id: 349967:HRD69_RS14625
uniprot id: A0A7D4TLH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ProQ family.
messages: Cytoplasm
messages: RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. May regulate ProP activity through an RNA-based, post-transcriptional mechanism.

349967:HRD69 RS16225
gene id: 349967:HRD69_RS16225
uniprot id: A0A7D4U0Q4
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family. Monothiol subfamily.
messages: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters.

349967:HRD69 RS01765
gene id: 349967:HRD69_RS01765
uniprot id: A0A7D4PQ47
names: Similarity
messages: Belongs to the GSP E family.

349967:HRD69 RS16245
gene id: 349967:HRD69_RS16245
uniprot id: A0A7D4PCE6
names: Domain
names: Function
names: Subunit
messages: Consists of two structural and functional domains: an N-terminal DNA-binding domain, approximately the first 60 residues, and a larger C-terminal domain, approximately 280 residues, which imparts the function of corepressor binding and oligomerization.
messages: Homodimer.
messages: Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.

349967:HRD69 RS02395
gene id: 349967:HRD69_RS02395
uniprot id: A0A7D4TEX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

349967:HRD69 RS02835
gene id: 349967:HRD69_RS02835
uniprot id: A0A7D4SV40
names: Similarity
messages: Belongs to the glutamate synthase family.

349967:HRD69 RS08400
gene id: 349967:HRD69_RS08400
uniprot id: A0A7D4PRV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3-dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position.
messages: Cytoplasm

349967:HRD69 RS10100
gene id: 349967:HRD69_RS10100
uniprot id: A0A7D4PS79
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

349967:HRD69 RS10275
gene id: 349967:HRD69_RS10275
uniprot id: A0A7D4SWE5
names: Similarity
messages: Belongs to the YkuD family.

349967:HRD69 RS05045
gene id: 349967:HRD69_RS05045
uniprot id: A0A7D4TXF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS14765
gene id: 349967:HRD69_RS14765
uniprot id: A0A7D4PBV1
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

349967:HRD69 RS11900
gene id: 349967:HRD69_RS11900
uniprot id: A0A7D4P2S3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4 family.
messages: Composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: Membrane

349967:HRD69 RS16510
gene id: 349967:HRD69_RS16510
uniprot id: A0A7D4PNA0
names: Similarity
messages: Belongs to the KAE1 / TsaD family. TsaB subfamily.

349967:HRD69 RS06540
gene id: 349967:HRD69_RS06540
uniprot id: A0A7D4P9N8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

349967:HRD69 RS14420
gene id: 349967:HRD69_RS14420
uniprot id: A0A7D4P3I0
names: Function
names: Similarity
messages: Belongs to the N(4)-acetylcytidine amidohydrolase family.
messages: Catalyzes the hydrolysis of N(4)-acetylcytidine (ac4C).

349967:HRD69 RS05055
gene id: 349967:HRD69_RS05055
uniprot id: A0A7D4TZN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm

349967:HRD69 RS16430
gene id: 349967:HRD69_RS16430
uniprot id: A0A7D4TIF6
names: Function
names: Similarity
messages: Belongs to the glutathione peroxidase family. BtuE subfamily.
messages: Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent.

349967:HRD69 RS20205
gene id: 349967:HRD69_RS20205
uniprot id: A0A7D4U5C9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. tRNA (adenine-N(6)-)-methyltransferase family.
messages: Cytoplasm
messages: Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).

349967:HRD69 RS01695
gene id: 349967:HRD69_RS01695
uniprot id: A0A7D4T4X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

349967:HRD69 RS00860
gene id: 349967:HRD69_RS00860
uniprot id: A0A7D4PN66
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

349967:HRD69 RS18925
gene id: 349967:HRD69_RS18925
uniprot id: A0A7D4PU96
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

349967:HRD69 RS02100
gene id: 349967:HRD69_RS02100
uniprot id: A0A7D4PAF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

349967:HRD69 RS04635
gene id: 349967:HRD69_RS04635
uniprot id: A0A7D4TZJ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily.
messages: Cell outer membrane
messages: Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

349967:HRD69 RS13705
gene id: 349967:HRD69_RS13705
uniprot id: A0A7D4SWZ5
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Secreted

349967:HRD69 RS10170
gene id: 349967:HRD69_RS10170
uniprot id: A0A7D4SVV5
names: Similarity
messages: Belongs to the thioredoxin family.

349967:HRD69 RS18720
gene id: 349967:HRD69_RS18720
uniprot id: A0A7D4PHM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

349967:HRD69 RS16705
gene id: 349967:HRD69_RS16705
uniprot id: A0A7D4P721
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily.
messages: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
messages: Cytoplasm

349967:HRD69 RS03705
gene id: 349967:HRD69_RS03705
uniprot id: A0A7D4PNX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

349967:HRD69 RS01545
gene id: 349967:HRD69_RS01545
uniprot id: A0A7D4PQ30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS04410
gene id: 349967:HRD69_RS04410
uniprot id: A0A7D4P2G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

349967:HRD69 RS07800
gene id: 349967:HRD69_RS07800
uniprot id: A0A7D4U0B7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

349967:HRD69 RS00395
gene id: 349967:HRD69_RS00395
uniprot id: A0A7D4P7W1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS03480
gene id: 349967:HRD69_RS03480
uniprot id: A0A7D4T100
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

349967:HRD69 RS07210
gene id: 349967:HRD69_RS07210
uniprot id: A0A7D4TY51
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GSP G family.
messages: Cell inner membrane
messages: Membrane
messages: Type II secretion system is composed of four main components: the outer membrane complex, the inner membrane complex, the cytoplasmic secretion ATPase and the periplasm-spanning pseudopilus. Forms homomultimers.

349967:HRD69 RS06200
gene id: 349967:HRD69_RS06200
uniprot id: A0A7D4T5Y6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

349967:HRD69 RS08655
gene id: 349967:HRD69_RS08655
uniprot id: A0A7D4T6F6
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

349967:HRD69 RS16260
gene id: 349967:HRD69_RS16260
uniprot id: A0A7D4P6Z4
names: Similarity
messages: Belongs to the CFA/CMAS family.

349967:HRD69 RS11500
gene id: 349967:HRD69_RS11500
uniprot id: A0A7D4PM42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpA family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

349967:HRD69 RS10750
gene id: 349967:HRD69_RS10750
uniprot id: A0A7D4U322
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

349967:HRD69 RS06280
gene id: 349967:HRD69_RS06280
uniprot id: A0A7D4SVS1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS15450
gene id: 349967:HRD69_RS15450
uniprot id: A0A7D4TI77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

349967:HRD69 RS01870
gene id: 349967:HRD69_RS01870
uniprot id: A0A7D4PQ55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase GyrB family.
messages: Belongs to the type II topoisomerase family. ParE type 1 subfamily.
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

349967:HRD69 RS16270
gene id: 349967:HRD69_RS16270
uniprot id: A0A7D4PSW9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Multidrug efflux pump that functions probably as a Na(+)/drug antiporter.

349967:HRD69 RS18050
gene id: 349967:HRD69_RS18050
uniprot id: A0A7D4PU38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Membrane

349967:HRD69 RS06325
gene id: 349967:HRD69_RS06325
uniprot id: A0A7D4U1T8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Gfo/Idh/MocA family.
messages: Homotetramer.
messages: Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).

349967:HRD69 RS17150
gene id: 349967:HRD69_RS17150
uniprot id: A0A7D4P9M6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs.
messages: Cytoplasm
messages: Interacts with TusE.

349967:HRD69 RS15970
gene id: 349967:HRD69_RS15970
uniprot id: A0A7D4PN61
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

349967:HRD69 RS04775
gene id: 349967:HRD69_RS04775
uniprot id: A0A7D4PP72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

349967:HRD69 RS19145
gene id: 349967:HRD69_RS19145
uniprot id: A0A7D4U552
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

349967:HRD69 RS13690
gene id: 349967:HRD69_RS13690
uniprot id: A0A7D4PSX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space.
messages: In the C-terminal section; belongs to the glycosyl hydrolase 73 family.
messages: In the N-terminal section; belongs to the FlgJ family.
messages: Periplasm

349967:HRD69 RS14440
gene id: 349967:HRD69_RS14440
uniprot id: A0A7D4P6L7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

349967:HRD69 RS09545
gene id: 349967:HRD69_RS09545
uniprot id: A0A7D4TGK9
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

349967:HRD69 RS08070
gene id: 349967:HRD69_RS08070
uniprot id: A0A7D4PLD7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Homodimer.
messages: May be involved in cell division.

349967:HRD69 RS08050
gene id: 349967:HRD69_RS08050
uniprot id: A0A7D4P389
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

349967:HRD69 RS04050
gene id: 349967:HRD69_RS04050
uniprot id: A0A7D4P9M9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell inner membrane
messages: Forms a membrane-associated complex with FtsE.
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in cellular division.

349967:HRD69 RS12285
gene id: 349967:HRD69_RS12285
uniprot id: A0A7D4T2P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane

349967:HRD69 RS12105
gene id: 349967:HRD69_RS12105
uniprot id: A0A7D4TZD3
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS04220
gene id: 349967:HRD69_RS04220
uniprot id: A0A7D4TFA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
messages: Cytoplasm
messages: Homodimer.

349967:HRD69 RS05110
gene id: 349967:HRD69_RS05110
uniprot id: A0A7D4PI49
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.
messages: Cytoplasm

349967:HRD69 RS10040
gene id: 349967:HRD69_RS10040
uniprot id: A0A7D4SYB7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

349967:HRD69 RS19240
gene id: 349967:HRD69_RS19240
uniprot id: A0A7D4U1Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Membrane
messages: Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

349967:HRD69 RS01800
gene id: 349967:HRD69_RS01800
uniprot id: A0A7D4TKW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Cell membrane
messages: Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
messages: Membrane
messages: The accessory proteins ExbB and ExbD seem to form a complex with TonB.

349967:HRD69 RS20025
gene id: 349967:HRD69_RS20025
uniprot id: A0A7D4PAB9
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
messages: Belongs to the globin family. Two-domain flavohemoproteins subfamily.
messages: Binds 1 FAD per subunit.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Consists of two distinct domains; an N-terminal heme-containing oxygen-binding domain and a C-terminal reductase domain with binding sites for FAD and NAD(P)H.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS18680
gene id: 349967:HRD69_RS18680
uniprot id: A0A7D4PE66
names: Similarity
messages: Belongs to the sodium:galactoside symporter (TC 2.A.2) family.

349967:HRD69 RS02300
gene id: 349967:HRD69_RS02300
uniprot id: A0A7D4P0P7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RlmG family.
messages: Cytoplasm
messages: Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.

349967:HRD69 RS16355
gene id: 349967:HRD69_RS16355
uniprot id: A0A7D4P3X8
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.

349967:HRD69 RS17825
gene id: 349967:HRD69_RS17825
uniprot id: A0A7D4P523
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribosome modulation factor family.
messages: Cytoplasm
messages: During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes).

349967:HRD69 RS06340
gene id: 349967:HRD69_RS06340
uniprot id: A0A7D4P9L9
names: Similarity
messages: Belongs to the pirin family.

349967:HRD69 RS17545
gene id: 349967:HRD69_RS17545
uniprot id: A0A7D4U184
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS08975
gene id: 349967:HRD69_RS08975
uniprot id: A0A7D4TMT7
names: Caution
names: Function
messages: Activates the small RNA gene sgrS under glucose-phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS15840
gene id: 349967:HRD69_RS15840
uniprot id: A0A7D4P6W0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

349967:HRD69 RS15790
gene id: 349967:HRD69_RS15790
uniprot id: A0A7D4TIA6
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family.
messages: Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria.

349967:HRD69 RS00025
gene id: 349967:HRD69_RS00025
uniprot id: A0A7D4TYD6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

349967:HRD69 RS08680
gene id: 349967:HRD69_RS08680
uniprot id: A0A7D4U0I7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

349967:HRD69 RS12110
gene id: 349967:HRD69_RS12110
uniprot id: A0A7D4U3E6
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

349967:HRD69 RS10280
gene id: 349967:HRD69_RS10280
uniprot id: A0A7D4SVV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NqrA family.
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

349967:HRD69 RS15430
gene id: 349967:HRD69_RS15430
uniprot id: A0A7D4P5V1
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

349967:HRD69 RS13010
gene id: 349967:HRD69_RS13010
uniprot id: A0A7D4PS48
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS17015
gene id: 349967:HRD69_RS17015
uniprot id: A0A7D4TM44
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS13125
gene id: 349967:HRD69_RS13125
uniprot id: A0A7D4PST8
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial microcompartment
messages: Belongs to the bacterial microcompartments protein family.

349967:HRD69 RS03045
gene id: 349967:HRD69_RS03045
uniprot id: A0A7D4SUG6
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS15900
gene id: 349967:HRD69_RS15900
uniprot id: A0A7D4TLV1
names: Similarity
messages: Belongs to the peptidase S1B family.

349967:HRD69 RS20235
gene id: 349967:HRD69_RS20235
uniprot id: A0A7D4P7X2
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

349967:HRD69 RS19335
gene id: 349967:HRD69_RS19335
uniprot id: A0A7D4TQN4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NapB family.
messages: Binds 2 heme C groups per subunit.
messages: Component of the periplasmic nitrate reductase NapAB complex composed of NapA and NapB.
messages: Electron transfer subunit of the periplasmic nitrate reductase complex NapAB.
messages: Periplasm

349967:HRD69 RS03650
gene id: 349967:HRD69_RS03650
uniprot id: A0A7D4TIQ1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Divalent metal cations. Mg(2+) or Mn(2+).
messages: Homodimer.
messages: mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some mRNAs and stabilizes RNA against 5'-processing. Has preference for mRNAs with a 5'-end purine. Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates.

349967:HRD69 RS11310
gene id: 349967:HRD69_RS11310
uniprot id: A0A7D4PBY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS13425
gene id: 349967:HRD69_RS13425
uniprot id: A0A7D4PCJ4
names: Function
messages: Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase.

349967:HRD69 RS03895
gene id: 349967:HRD69_RS03895
uniprot id: A0A7D4T5H1
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

349967:HRD69 RS09460
gene id: 349967:HRD69_RS09460
uniprot id: A0A7D4U0Q2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BtuF family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC.
messages: Periplasm
messages: The complex is composed of two ATP-binding proteins (BtuD), two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).

349967:HRD69 RS13550
gene id: 349967:HRD69_RS13550
uniprot id: A0A7D4PBG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

349967:HRD69 RS15270
gene id: 349967:HRD69_RS15270
uniprot id: A0A7D4P6R6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

349967:HRD69 RS04340
gene id: 349967:HRD69_RS04340
uniprot id: A0A7D4T5K8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. WecA subfamily.
messages: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55).
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS03280
gene id: 349967:HRD69_RS03280
uniprot id: A0A7D4TF41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

349967:HRD69 RS14265
gene id: 349967:HRD69_RS14265
uniprot id: A0A7D4SWP2
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS02595
gene id: 349967:HRD69_RS02595
uniprot id: A0A7D4PK74
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EcpA/MatB fimbrillin family.
messages: Fimbrium
messages: Self-associates. Forms filaments. Interacts with EcpD.

349967:HRD69 RS01930
gene id: 349967:HRD69_RS01930
uniprot id: A0A7D4U086
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
messages: Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the cytidylyltransferase family.
messages: In the N-terminal section; belongs to the carbohydrate kinase PfkB family.

349967:HRD69 RS16370
gene id: 349967:HRD69_RS16370
uniprot id: A0A7D4P9G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

349967:HRD69 RS14930
gene id: 349967:HRD69_RS14930
uniprot id: A0A7D4PGK1
names: Function
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.

349967:HRD69 RS19555
gene id: 349967:HRD69_RS19555
uniprot id: A0A7D4TQQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial export usher family.
messages: Cell outer membrane
messages: Membrane

349967:HRD69 RS00950
gene id: 349967:HRD69_RS00950
uniprot id: A0A7D4P657
names: Similarity
messages: Belongs to the EndA/NucM nuclease family.

349967:HRD69 RS08145
gene id: 349967:HRD69_RS08145
uniprot id: A0A7D4PB49
names: Similarity
messages: Belongs to the UPF0306 family.

349967:HRD69 RS01000
gene id: 349967:HRD69_RS01000
uniprot id: A0A7D4TKL7
names: Similarity
messages: Belongs to the YggT family.

349967:HRD69 RS01985
gene id: 349967:HRD69_RS01985
uniprot id: A0A7D4PQ64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

349967:HRD69 RS04230
gene id: 349967:HRD69_RS04230
uniprot id: A0A7D4TIV6
names: Function
names: Similarity
messages: Belongs to the frataxin family.
messages: Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.

349967:HRD69 RS07760
gene id: 349967:HRD69_RS07760
uniprot id: A0A7D4SVC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

349967:HRD69 RS05285
gene id: 349967:HRD69_RS05285
uniprot id: A0A7D4PA11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

349967:HRD69 RS04480
gene id: 349967:HRD69_RS04480
uniprot id: A0A7D4U172
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS07450
gene id: 349967:HRD69_RS07450
uniprot id: A0A7D4U237
names: Similarity
messages: Belongs to the glycosyl hydrolase 8 (cellulase D) family.

349967:HRD69 RS14720
gene id: 349967:HRD69_RS14720
uniprot id: A0A7D4TPA4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS06900
gene id: 349967:HRD69_RS06900
uniprot id: A0A7D4P2Z9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

349967:HRD69 RS18280
gene id: 349967:HRD69_RS18280
uniprot id: A0A7D4SXS2
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

349967:HRD69 RS05370
gene id: 349967:HRD69_RS05370
uniprot id: A0A7D4TFH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbsD / FucU family. RbsD subfamily.
messages: Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
messages: Cytoplasm
messages: Homodecamer.

349967:HRD69 RS06720
gene id: 349967:HRD69_RS06720
uniprot id: A0A7D4T1H8
names: Similarity
messages: Belongs to the UPF0270 family.

349967:HRD69 RS01900
gene id: 349967:HRD69_RS01900
uniprot id: A0A7D4U5E6
names: Similarity
messages: Belongs to the UPF0441 family.

349967:HRD69 RS13545
gene id: 349967:HRD69_RS13545
uniprot id: A0A7D4P3B6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Mediates magnesium influx to the cytosol.
messages: Membrane

349967:HRD69 RS17325
gene id: 349967:HRD69_RS17325
uniprot id: A0A7D4TIN2
names: Similarity
names: Subunit
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

349967:HRD69 RS15610
gene id: 349967:HRD69_RS15610
uniprot id: A0A7D4P4N6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS11080
gene id: 349967:HRD69_RS11080
uniprot id: A0A7D4PBV6
names: Similarity
messages: Belongs to the band 7/mec-2 family.

349967:HRD69 RS09455
gene id: 349967:HRD69_RS09455
uniprot id: A0A7D4U2P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

349967:HRD69 RS05505
gene id: 349967:HRD69_RS05505
uniprot id: A0A7D4PA38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Part of the phosphate (Pho) regulon, which plays a key role in phosphate homeostasis. PhoU is essential for the repression of the Pho regulon at high phosphate conditions.

349967:HRD69 RS09005
gene id: 349967:HRD69_RS09005
uniprot id: A0A7D4U0L1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

349967:HRD69 RS03710
gene id: 349967:HRD69_RS03710
uniprot id: A0A7D4PQL0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

349967:HRD69 RS05860
gene id: 349967:HRD69_RS05860
uniprot id: A0A7D4T1C3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhE family.
messages: Cytoplasm
messages: Necessary for formate dehydrogenase activity.

349967:HRD69 RS12865
gene id: 349967:HRD69_RS12865
uniprot id: A0A7D4U3K0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion.
messages: Homodimer.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

349967:HRD69 RS12245
gene id: 349967:HRD69_RS12245
uniprot id: A0A7D4P616
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS13775
gene id: 349967:HRD69_RS13775
uniprot id: A0A7D4P6G0
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

349967:HRD69 RS05930
gene id: 349967:HRD69_RS05930
uniprot id: A0A7D4P2R9
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.

349967:HRD69 RS01970
gene id: 349967:HRD69_RS01970
uniprot id: A0A7D4P3F0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

349967:HRD69 RS07630
gene id: 349967:HRD69_RS07630
uniprot id: A0A7D4PLA7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

349967:HRD69 RS04860
gene id: 349967:HRD69_RS04860
uniprot id: A0A7D4P6W1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

349967:HRD69 RS14810
gene id: 349967:HRD69_RS14810
uniprot id: A0A7D4TR99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

349967:HRD69 RS10765
gene id: 349967:HRD69_RS10765
uniprot id: A0A7D4PAU1
names: Similarity
messages: Belongs to the phosphopentomutase family.

349967:HRD69 RS14820
gene id: 349967:HRD69_RS14820
uniprot id: A0A7D4PMU5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

349967:HRD69 RS00765
gene id: 349967:HRD69_RS00765
uniprot id: A0A7D4PJQ1
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

349967:HRD69 RS03235
gene id: 349967:HRD69_RS03235
uniprot id: A0A7D4PNT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

349967:HRD69 RS15710
gene id: 349967:HRD69_RS15710
uniprot id: A0A7D4PC98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS11120
gene id: 349967:HRD69_RS11120
uniprot id: A0A7D4PM22
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxH family.
messages: Binds 2 Mn(2+) ions per subunit in a binuclear metal center.
messages: Cell inner membrane
messages: Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

349967:HRD69 RS12360
gene id: 349967:HRD69_RS12360
uniprot id: A0A7D4P442
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

349967:HRD69 RS14365
gene id: 349967:HRD69_RS14365
uniprot id: A0A7D4SX40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0266 family.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS05520
gene id: 349967:HRD69_RS05520
uniprot id: A0A7D4P2P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS12370
gene id: 349967:HRD69_RS12370
uniprot id: A0A7D4PSP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

349967:HRD69 RS06175
gene id: 349967:HRD69_RS06175
uniprot id: A0A7D4SVR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Cdh family.
messages: Membrane

349967:HRD69 RS10465
gene id: 349967:HRD69_RS10465
uniprot id: A0A7D4PR20
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

349967:HRD69 RS13835
gene id: 349967:HRD69_RS13835
uniprot id: A0A7D4T7H6
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

349967:HRD69 RS11390
gene id: 349967:HRD69_RS11390
uniprot id: A0A7D4SW41
names: Similarity
messages: Belongs to the asparagine synthetase family.

349967:HRD69 RS19225
gene id: 349967:HRD69_RS19225
uniprot id: A0A7D4T8K1
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

349967:HRD69 RS16850
gene id: 349967:HRD69_RS16850
uniprot id: A0A7D4SXI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Part of an ABC transporter complex involved in carbohydrate import. Could be involved in ribose, galactose and/or methyl galactoside import. Responsible for energy coupling to the transport system.

349967:HRD69 RS08935
gene id: 349967:HRD69_RS08935
uniprot id: A0A7D4PQL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNF2/RAD54 helicase family. RapA subfamily.
messages: Interacts with the RNAP. Has a higher affinity for the core RNAP than for the holoenzyme. Its ATPase activity is stimulated by binding to RNAP.
messages: Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair.

349967:HRD69 RS17550
gene id: 349967:HRD69_RS17550
uniprot id: A0A7D4U4T0
names: Similarity
messages: Belongs to the IucA/IucC family.

349967:HRD69 RS00545
gene id: 349967:HRD69_RS00545
uniprot id: A0A7D4PD64
names: Function
names: Similarity
messages: Belongs to the peptidase M16 family.
messages: Endopeptidase that degrades small peptides of less than 7 kDa, such as glucagon and insulin.

349967:HRD69 RS20210
gene id: 349967:HRD69_RS20210
uniprot id: A0A7D4U386
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. SrmB subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity.
messages: Interacts with the 50S ribosomal subunit.

349967:HRD69 RS17920
gene id: 349967:HRD69_RS17920
uniprot id: A0A7D4P9R7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MukE family.
messages: Interacts, and probably forms a ternary complex, with MukF and MukB. The complex formation is stimulated by calcium or magnesium.
messages: Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF.
messages: nucleoid

349967:HRD69 RS13265
gene id: 349967:HRD69_RS13265
uniprot id: A0A7D4T7E0
names: Function
names: Similarity
messages: Belongs to the CobU/CobP family.
messages: Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.

349967:HRD69 RS00290
gene id: 349967:HRD69_RS00290
uniprot id: A0A7D4P7V5
names: Similarity
messages: Belongs to the UPF0253 family.

349967:HRD69 RS11050
gene id: 349967:HRD69_RS11050
uniprot id: A0A7D4TKM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat-stable enterotoxin family.
messages: Secreted

349967:HRD69 RS18100
gene id: 349967:HRD69_RS18100
uniprot id: A0A7D4TME8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

349967:HRD69 RS15930
gene id: 349967:HRD69_RS15930
uniprot id: A0A7D4PD58
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS13400
gene id: 349967:HRD69_RS13400
uniprot id: A0A7D4TZT7
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS05605
gene id: 349967:HRD69_RS05605
uniprot id: A0A7D4P9F5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

349967:HRD69 RS00870
gene id: 349967:HRD69_RS00870
uniprot id: A0A7D4PD91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LysR transcriptional regulatory family.
messages: Controls the transcription of genes involved in arginine and lysine metabolism.
messages: Homodimer.

349967:HRD69 RS06040
gene id: 349967:HRD69_RS06040
uniprot id: A0A7D4P499
names: Similarity
messages: Belongs to the ner transcriptional regulatory family.

349967:HRD69 RS03620
gene id: 349967:HRD69_RS03620
uniprot id: A0A7D4SUK3
names: Similarity
messages: Belongs to the GARS family.

349967:HRD69 RS20120
gene id: 349967:HRD69_RS20120
uniprot id: A0A7D4PDC9
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
messages: A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.
messages: Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
messages: Homodimer.
messages: Induced by MurNAc 6-phosphate that releases the repressor MurR from the DNA. Repressed by MurR in the absence of MurNAc 6-phosphate.
messages: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.

349967:HRD69 RS13730
gene id: 349967:HRD69_RS13730
uniprot id: A0A7D4THQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliN/MopA/SpaO family.
messages: Cell membrane
messages: FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

349967:HRD69 RS10520
gene id: 349967:HRD69_RS10520
uniprot id: A0A7D4TKI2
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

349967:HRD69 RS01350
gene id: 349967:HRD69_RS01350
uniprot id: A0A7D4SUW2
names: Similarity
messages: Belongs to the antirestriction protein family.

349967:HRD69 RS06895
gene id: 349967:HRD69_RS06895
uniprot id: A0A7D4P4L4
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

349967:HRD69 RS00685
gene id: 349967:HRD69_RS00685
uniprot id: A0A7D4TEK2
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

349967:HRD69 RS11595
gene id: 349967:HRD69_RS11595
uniprot id: A0A7D4PSJ8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

349967:HRD69 RS11260
gene id: 349967:HRD69_RS11260
uniprot id: A0A7D4T2I9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

349967:HRD69 RS04740
gene id: 349967:HRD69_RS04740
uniprot id: A0A7D4TZL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

349967:HRD69 RS02890
gene id: 349967:HRD69_RS02890
uniprot id: A0A7D4P8K1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm

349967:HRD69 RS03565
gene id: 349967:HRD69_RS03565
uniprot id: A0A7D4PQK3
names: Cofactor
messages: Can also use Mn(2+) ion.

349967:HRD69 RS11265
gene id: 349967:HRD69_RS11265
uniprot id: A0A7D4TNA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transpeptidase family. MrdA subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall.
messages: Cell inner membrane

349967:HRD69 RS12980
gene id: 349967:HRD69_RS12980
uniprot id: A0A7D4PBB7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Equilibrium between an active dimeric form, an inactive hexameric form and higher aggregates. Interconversion between the various forms is largely reversible and is influenced by the natural substrates and inhibitors of the enzyme.
messages: Feedback inhibited by histidine.

349967:HRD69 RS11425
gene id: 349967:HRD69_RS11425
uniprot id: A0A7D4U384
names: Similarity
messages: Belongs to the outer membrane porin (Opr) (TC 1.B.25) family.

349967:HRD69 RS09050
gene id: 349967:HRD69_RS09050
uniprot id: A0A7D4PQM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster. Acts by binding directly to DNA. May also regulate the expression of genes outside the dcw cluster.
messages: nucleoid

349967:HRD69 RS13295
gene id: 349967:HRD69_RS13295
uniprot id: A0A7D4U1N1
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

349967:HRD69 RS08650
gene id: 349967:HRD69_RS08650
uniprot id: A0A7D4TMQ5
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

349967:HRD69 RS02940
gene id: 349967:HRD69_RS02940
uniprot id: A0A7D4SV48
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptC family.
messages: Cell inner membrane
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptA and the LptBFG transporter complex.
messages: Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA.
messages: Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

349967:HRD69 RS18815
gene id: 349967:HRD69_RS18815
uniprot id: A0A7D4PTM6
names: Similarity
messages: Belongs to the YjdM family.

349967:HRD69 RS03105
gene id: 349967:HRD69_RS03105
uniprot id: A0A7D4P9F3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the cytochrome b562 family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per molecule.
messages: Electron-transport protein of unknown function.

349967:HRD69 RS10420
gene id: 349967:HRD69_RS10420
uniprot id: A0A7D4U2G7
names: Function
messages: This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.

349967:HRD69 RS17875
gene id: 349967:HRD69_RS17875
uniprot id: A0A7D4TIT2
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

349967:HRD69 RS19475
gene id: 349967:HRD69_RS19475
uniprot id: A0A7D4U573
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

349967:HRD69 RS17510
gene id: 349967:HRD69_RS17510
uniprot id: A0A7D4SXE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbE subfamily.
messages: Cell inner membrane

349967:HRD69 RS00675
gene id: 349967:HRD69_RS00675
uniprot id: A0A7D4TKI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.

349967:HRD69 RS12925
gene id: 349967:HRD69_RS12925
uniprot id: A0A7D4SWV4
names: Similarity
messages: Belongs to the UPF0053 family.

349967:HRD69 RS13635
gene id: 349967:HRD69_RS13635
uniprot id: A0A7D4TLB2
names: Function
names: Similarity
messages: Belongs to the FlgN family.
messages: Required for the efficient initiation of filament assembly.

349967:HRD69 RS17085
gene id: 349967:HRD69_RS17085
uniprot id: A0A7D4SXJ6
names: Subcellular Location Annotation
messages: Cytoplasm

349967:HRD69 RS11985
gene id: 349967:HRD69_RS11985
uniprot id: A0A7D4TKT8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

349967:HRD69 RS17480
gene id: 349967:HRD69_RS17480
uniprot id: A0A7D4P502
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily.
messages: Cell membrane
messages: K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels.

349967:HRD69 RS09075
gene id: 349967:HRD69_RS09075
uniprot id: A0A7D4SVN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

349967:HRD69 RS00775
gene id: 349967:HRD69_RS00775
uniprot id: A0A7D4SU10
names: Subcellular Location Annotation
messages: Cell inner membrane

349967:HRD69 RS15730
gene id: 349967:HRD69_RS15730
uniprot id: A0A7D4P4P4
names: Similarity
messages: Belongs to the ArsC family.

349967:HRD69 RS05360
gene id: 349967:HRD69_RS05360
uniprot id: A0A7D4TLU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).

349967:HRD69 RS13235
gene id: 349967:HRD69_RS13235
uniprot id: A0A7D4PMK4
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

349967:HRD69 RS07985
gene id: 349967:HRD69_RS07985
uniprot id: A0A7D4T6B0
names: Similarity
messages: Belongs to the peptidase S13 family.

349967:HRD69 RS03845
gene id: 349967:HRD69_RS03845
uniprot id: A0A7D4T8X2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiD family.
messages: Binds 1 prenylated FMN (prenyl-FMN) per subunit.
messages: Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
messages: Cell membrane
messages: Homohexamer.

349967:HRD69 RS01835
gene id: 349967:HRD69_RS01835
uniprot id: A0A7D4P0L4
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

349967:HRD69 RS08570
gene id: 349967:HRD69_RS08570
uniprot id: A0A7D4TYH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. RsmC family.
messages: Cytoplasm
messages: Monomer.
messages: Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.

349967:HRD69 RS14405
gene id: 349967:HRD69_RS14405
uniprot id: A0A7D4U030
names: Similarity
messages: Belongs to the UPF0181 family.

349967:HRD69 RS03365
gene id: 349967:HRD69_RS03365
uniprot id: A0A7D4SUI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS13575
gene id: 349967:HRD69_RS13575
uniprot id: A0A7D4U5L3
names: Function
messages: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY.

349967:HRD69 RS17440
gene id: 349967:HRD69_RS17440
uniprot id: A0A7D4U175
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

349967:HRD69 RS19310
gene id: 349967:HRD69_RS19310
uniprot id: A0A7D4PHS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.

349967:HRD69 RS03930
gene id: 349967:HRD69_RS03930
uniprot id: A0A7D4P8U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LysR transcriptional regulatory family.
messages: Cytoplasm

349967:HRD69 RS02230
gene id: 349967:HRD69_RS02230
uniprot id: A0A7D4PDL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

349967:HRD69 RS14935
gene id: 349967:HRD69_RS14935
uniprot id: A0A7D4PMV2
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.

349967:HRD69 RS10525
gene id: 349967:HRD69_RS10525
uniprot id: A0A7D4TYY8
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

349967:HRD69 RS13570
gene id: 349967:HRD69_RS13570
uniprot id: A0A7D4P4B6
names: Similarity
messages: Belongs to the MotB family.

349967:HRD69 RS17750
gene id: 349967:HRD69_RS17750
uniprot id: A0A7D4SXN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HspQ family.
messages: Cytoplasm
messages: Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress.

349967:HRD69 RS04565
gene id: 349967:HRD69_RS04565
uniprot id: A0A7D4TLI4
names: Similarity
messages: Belongs to the UPF0438 family.

349967:HRD69 RS00190
gene id: 349967:HRD69_RS00190
uniprot id: A0A7D4PN03
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Monomer.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

349967:HRD69 RS10065
gene id: 349967:HRD69_RS10065
uniprot id: A0A7D4PBM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane
messages: Responsible for the transport of C4-dicarboxylates.

349967:HRD69 RS00635
gene id: 349967:HRD69_RS00635
uniprot id: A0A7D4P1T2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS00250
gene id: 349967:HRD69_RS00250
uniprot id: A0A7D4T4N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

349967:HRD69 RS09500
gene id: 349967:HRD69_RS09500
uniprot id: A0A7D4PQV5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

349967:HRD69 RS06225
gene id: 349967:HRD69_RS06225
uniprot id: A0A7D4TZZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein B family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

349967:HRD69 RS07685
gene id: 349967:HRD69_RS07685
uniprot id: A0A7D4P1T8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily.
messages: Homodimer.
messages: With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P.

349967:HRD69 RS06770
gene id: 349967:HRD69_RS06770
uniprot id: A0A7D4P4X1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family. KefG subfamily.
messages: Cell inner membrane
messages: Interacts with KefB.
messages: Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefB.

349967:HRD69 RS06835
gene id: 349967:HRD69_RS06835
uniprot id: A0A7D4T1I6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

349967:HRD69 RS13860
gene id: 349967:HRD69_RS13860
uniprot id: A0A7D4U1S1
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family.
messages: In the N-terminal section; belongs to the proline dehydrogenase family.
messages: Oxidizes proline to glutamate for use as a carbon and nitrogen source.

349967:HRD69 RS03870
gene id: 349967:HRD69_RS03870
uniprot id: A0A7D4PKI9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatB family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

349967:HRD69 RS08085
gene id: 349967:HRD69_RS08085
uniprot id: A0A7D4SVD6
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

349967:HRD69 RS13070
gene id: 349967:HRD69_RS13070
uniprot id: A0A7D4U3M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetokinase family. PduW subfamily.
messages: Cytoplasm

349967:HRD69 RS05340
gene id: 349967:HRD69_RS05340
uniprot id: A0A7D4PKU3
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS02010
gene id: 349967:HRD69_RS02010
uniprot id: A0A7D4SU74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

349967:HRD69 RS14445
gene id: 349967:HRD69_RS14445
uniprot id: A0A7D4P4H5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CopC family.
messages: Involved in copper resistance.
messages: Periplasm

349967:HRD69 RS08160
gene id: 349967:HRD69_RS08160
uniprot id: A0A7D4P395
names: Caution
names: Function
names: Similarity
messages: Belongs to the ribose 1,5-bisphosphokinase family.
messages: Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS02775
gene id: 349967:HRD69_RS02775
uniprot id: A0A7D4P0R9
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS03940
gene id: 349967:HRD69_RS03940
uniprot id: A0A7D4P9M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS07670
gene id: 349967:HRD69_RS07670
uniprot id: A0A7D4TY96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FrdC family.
messages: Cell membrane
messages: Part of an enzyme complex containing four subunits: a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD).
messages: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used in anaerobic growth, and succinate dehydrogenase is used in aerobic growth. Anchors the catalytic components of the fumarate reductase complex to the cell inner membrane, binds quinones.

349967:HRD69 RS00015
gene id: 349967:HRD69_RS00015
uniprot id: A0A7D4TVU7
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carbamylation allows a single lysine to coordinate two nickel ions.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

349967:HRD69 RS11030
gene id: 349967:HRD69_RS11030
uniprot id: A0A7D4T2E8
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Catalyzes the phosphorylation of guanosine and inosine to GMP and IMP, respectively.

349967:HRD69 RS03830
gene id: 349967:HRD69_RS03830
uniprot id: A0A7D4P9L3
names: Function
names: Similarity
names: Subunit
messages: Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).
messages: In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
messages: Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.

349967:HRD69 RS05080
gene id: 349967:HRD69_RS05080
uniprot id: A0A7D4P6X5
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS19150
gene id: 349967:HRD69_RS19150
uniprot id: A0A7D4U2Z7
names: Subcellular Location Annotation
messages: Cytoplasm

349967:HRD69 RS03550
gene id: 349967:HRD69_RS03550
uniprot id: A0A7D4SY85
names: Domain
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 dependent methionine synthase family.
messages: Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
messages: Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.

349967:HRD69 RS09975
gene id: 349967:HRD69_RS09975
uniprot id: A0A7D4PLU7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm
messages: Homotetramer.

349967:HRD69 RS08065
gene id: 349967:HRD69_RS08065
uniprot id: A0A7D4PF52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

349967:HRD69 RS01690
gene id: 349967:HRD69_RS01690
uniprot id: A0A7D4TKS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

349967:HRD69 RS10220
gene id: 349967:HRD69_RS10220
uniprot id: A0A7D4TJJ4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).

349967:HRD69 RS02290
gene id: 349967:HRD69_RS02290
uniprot id: A0A7D4TYU6
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS04770
gene id: 349967:HRD69_RS04770
uniprot id: A0A7D4P2I5
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activity of this regulatory enzyme is affected by several metabolites. Allosterically and non-competitively inhibited by fructose 1,6-bisphosphate (FBP) and unphosphorylated phosphocarrier protein EIIA-Glc (III-Glc), an integral component of the bacterial phosphotransferase (PTS) system.
messages: Belongs to the FGGY kinase family.
messages: Homotetramer and homodimer (in equilibrium). Heterodimer with EIIA-Glc. Binds 1 zinc ion per glycerol kinase EIIA-Glc dimer. The zinc ion is important for dimerization.
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

349967:HRD69 RS01890
gene id: 349967:HRD69_RS01890
uniprot id: A0A7D4SU64
names: Function
names: Similarity
names: Subunit
messages: Acts on ADP-mannose and ADP-glucose as well as ADP-ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process.
messages: Belongs to the Nudix hydrolase family. NudF subfamily.
messages: Belongs to the Nudix hydrolase family. NudK subfamily.
messages: Homodimer.
messages: Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP-mannose as its preferred substrate, yielding GMP and mannose-1-phosphate.

349967:HRD69 RS14375
gene id: 349967:HRD69_RS14375
uniprot id: A0A7D4T316
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS04875
gene id: 349967:HRD69_RS04875
uniprot id: A0A7D4PP91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. FieF subfamily.
messages: Cell inner membrane
messages: Divalent metal cation transporter which exports Zn(2+), Cd(2+) and possibly Fe(2+). May be involved in zinc and iron detoxification by efflux.
messages: Homodimer.
messages: Membrane

349967:HRD69 RS17795
gene id: 349967:HRD69_RS17795
uniprot id: A0A7D4U2P4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpA family.
messages: Cell outer membrane
messages: Membrane
messages: Monomer and homodimer.
messages: The extracellular loops are most variable in sequence, and in some bacteria confer sensitivity to phage and/or colicins.
messages: With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage.

349967:HRD69 RS12340
gene id: 349967:HRD69_RS12340
uniprot id: A0A7D4PC64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

349967:HRD69 RS02205
gene id: 349967:HRD69_RS02205
uniprot id: A0A7D4P6D8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

349967:HRD69 RS09965
gene id: 349967:HRD69_RS09965
uniprot id: A0A7D4PS70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

349967:HRD69 RS09335
gene id: 349967:HRD69_RS09335
uniprot id: A0A7D4TYN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS06820
gene id: 349967:HRD69_RS06820
uniprot id: A0A7D4PL53
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

349967:HRD69 RS11810
gene id: 349967:HRD69_RS11810
uniprot id: A0A7D4P8H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0208 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

349967:HRD69 RS03175
gene id: 349967:HRD69_RS03175
uniprot id: A0A7D4T599
names: Subcellular Location Annotation
messages: Secreted

349967:HRD69 RS13030
gene id: 349967:HRD69_RS13030
uniprot id: A0A7D4SWV9
names: Similarity
messages: Belongs to the UPF0265 family.

349967:HRD69 RS13555
gene id: 349967:HRD69_RS13555
uniprot id: A0A7D4PCK3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FlhD family.
messages: Cytoplasm
messages: Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.
messages: Homodimer; disulfide-linked. Forms a heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers.
messages: The C-terminal region contains a putative helix-turn-helix (HTH) motif, suggesting that this region may bind DNA.

349967:HRD69 RS02990
gene id: 349967:HRD69_RS02990
uniprot id: A0A7D4P0T0
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

349967:HRD69 RS19990
gene id: 349967:HRD69_RS19990
uniprot id: A0A7D4U265
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
messages: Cytoplasm
messages: Homodimer.

349967:HRD69 RS19175
gene id: 349967:HRD69_RS19175
uniprot id: A0A7D4P7L7
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

349967:HRD69 RS15245
gene id: 349967:HRD69_RS15245
uniprot id: A0A7D4U215
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

349967:HRD69 RS19420
gene id: 349967:HRD69_RS19420
uniprot id: A0A7D4PP09
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0756 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS13665
gene id: 349967:HRD69_RS13665
uniprot id: A0A7D4PCL3
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

349967:HRD69 RS14730
gene id: 349967:HRD69_RS14730
uniprot id: A0A7D4TI20
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

349967:HRD69 RS15390
gene id: 349967:HRD69_RS15390
uniprot id: A0A7D4P4L9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial export usher family.
messages: Cell outer membrane
messages: Membrane

349967:HRD69 RS12090
gene id: 349967:HRD69_RS12090
uniprot id: A0A7D4T753
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS11870
gene id: 349967:HRD69_RS11870
uniprot id: A0A7D4T737
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the complex I 75 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Composed of 13 different subunits. Subunits NuoCD, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

349967:HRD69 RS13060
gene id: 349967:HRD69_RS13060
uniprot id: A0A7D4TL23
names: Function
messages: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

349967:HRD69 RS02115
gene id: 349967:HRD69_RS02115
uniprot id: A0A7D4PQ70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

349967:HRD69 RS16845
gene id: 349967:HRD69_RS16845
uniprot id: A0A7D4PNC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).

349967:HRD69 RS16750
gene id: 349967:HRD69_RS16750
uniprot id: A0A7D4SX88
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

349967:HRD69 RS19640
gene id: 349967:HRD69_RS19640
uniprot id: A0A7D4SY03
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

349967:HRD69 RS01775
gene id: 349967:HRD69_RS01775
uniprot id: A0A7D4PJZ1
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS00750
gene id: 349967:HRD69_RS00750
uniprot id: A0A7D4PN50
names: Similarity
messages: Belongs to the RecJ family.

349967:HRD69 RS19845
gene id: 349967:HRD69_RS19845
uniprot id: A0A7D4SY20
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

349967:HRD69 RS19365
gene id: 349967:HRD69_RS19365
uniprot id: A0A7D4U566
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

349967:HRD69 RS04315
gene id: 349967:HRD69_RS04315
uniprot id: A0A7D4PKM2
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

349967:HRD69 RS08945
gene id: 349967:HRD69_RS08945
uniprot id: A0A7D4PFC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS10755
gene id: 349967:HRD69_RS10755
uniprot id: A0A7D4U121
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

349967:HRD69 RS17870
gene id: 349967:HRD69_RS17870
uniprot id: A0A7D4T8A3
names: Similarity
messages: Belongs to the peptidase M1 family.

349967:HRD69 RS02215
gene id: 349967:HRD69_RS02215
uniprot id: A0A7D4P224
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

349967:HRD69 RS03445
gene id: 349967:HRD69_RS03445
uniprot id: A0A7D4PNV8
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.

349967:HRD69 RS08795
gene id: 349967:HRD69_RS08795
uniprot id: A0A7D4P236
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

349967:HRD69 RS03270
gene id: 349967:HRD69_RS03270
uniprot id: A0A7D4TL91
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

349967:HRD69 RS18045
gene id: 349967:HRD69_RS18045
uniprot id: A0A7D4PTF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LolA family.
messages: Monomer.
messages: Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
messages: Periplasm

349967:HRD69 RS11530
gene id: 349967:HRD69_RS11530
uniprot id: A0A7D4TH10
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

349967:HRD69 RS19435
gene id: 349967:HRD69_RS19435
uniprot id: A0A7D4T3Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamC family.
messages: Cell outer membrane
messages: Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

349967:HRD69 RS09535
gene id: 349967:HRD69_RS09535
uniprot id: A0A7D4TMY3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAPS reductase family. CysH subfamily.
messages: Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS12000
gene id: 349967:HRD69_RS12000
uniprot id: A0A7D4U3D8
names: Function
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
messages: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).

349967:HRD69 RS07835
gene id: 349967:HRD69_RS07835
uniprot id: A0A7D4P371
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

349967:HRD69 RS10395
gene id: 349967:HRD69_RS10395
uniprot id: A0A7D4TN51
names: Function
names: Similarity
messages: Belongs to the nucleoside phosphorylase PpnP family.
messages: Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions.

349967:HRD69 RS19185
gene id: 349967:HRD69_RS19185
uniprot id: A0A7D4PTQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS00480
gene id: 349967:HRD69_RS00480
uniprot id: A0A7D4TZM4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS02745
gene id: 349967:HRD69_RS02745
uniprot id: A0A7D4TWT0
names: Similarity
messages: Belongs to the GSP E family.

349967:HRD69 RS10620
gene id: 349967:HRD69_RS10620
uniprot id: A0A7D4TGS8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

349967:HRD69 RS08805
gene id: 349967:HRD69_RS08805
uniprot id: A0A7D4PBB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

349967:HRD69 RS08705
gene id: 349967:HRD69_RS08705
uniprot id: A0A7D4P556
names: Similarity
messages: Belongs to the transglycosylase Slt family.

349967:HRD69 RS02240
gene id: 349967:HRD69_RS02240
uniprot id: A0A7D4SV13
names: Function
names: Similarity
messages: Belongs to the FlgM family.
messages: Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA.

349967:HRD69 RS19245
gene id: 349967:HRD69_RS19245
uniprot id: A0A7D4U562
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic sulfate-binding protein family.
messages: Periplasm

349967:HRD69 RS14900
gene id: 349967:HRD69_RS14900
uniprot id: A0A7D4TJM0
names: Similarity
messages: Belongs to the UPF0229 family.

349967:HRD69 RS07460
gene id: 349967:HRD69_RS07460
uniprot id: A0A7D4P1S8
names: Function
messages: Required for maximal bacterial cellulose synthesis.

349967:HRD69 RS05580
gene id: 349967:HRD69_RS05580
uniprot id: A0A7D4TJ78
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.

349967:HRD69 RS06130
gene id: 349967:HRD69_RS06130
uniprot id: A0A7D4P9K1
names: Similarity
messages: Belongs to the YicC/YloC family.

349967:HRD69 RS10625
gene id: 349967:HRD69_RS10625
uniprot id: A0A7D4TKJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

349967:HRD69 RS02070
gene id: 349967:HRD69_RS02070
uniprot id: A0A7D4P896
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

349967:HRD69 RS18135
gene id: 349967:HRD69_RS18135
uniprot id: A0A7D4P9T5
names: Activity Regulation
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A peripheral cell membrane enzyme that catalyzes the oxidative decarboxylation of pyruvate to form acetate and CO(2). It channels electrons from the cytoplasm to the respiratory chain at the cell membrane via ubiquinone.
messages: Belongs to the TPP enzyme family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Cell membrane
messages: Has 4 domains; the Pyr domain which binds the pyrimidine moiety of the thiamine pyrophosphate cofactor, the FAD-binding domain, the PP-binding domain which binds the pyrophosphate portion of thiamine pyrophosphate and the C-terminal membrane binding region. The C-terminus is held closely against the rest of the protein and covers the active site; during activation it unfolds from the rest of the protein and forms an amphipathic helix upon membrane binding, exposing the active site.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The C-terminus inhibits activity; it has to move for the enzyme to be active. Activated by lipid-binding, which occurs via the C-terminus.

349967:HRD69 RS00260
gene id: 349967:HRD69_RS00260
uniprot id: A0A7D4THY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RcsF family.
messages: Cell outer membrane
messages: Essential component of the Rcs signaling system, which controls transcription of numerous genes. Plays a role in signal transduction from the cell surface to the histidine kinase RcsC. May detect outer membrane defects.

349967:HRD69 RS05460
gene id: 349967:HRD69_RS05460
uniprot id: A0A7D4TLV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

349967:HRD69 RS05075
gene id: 349967:HRD69_RS05075
uniprot id: A0A7D4P9Z4
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS02120
gene id: 349967:HRD69_RS02120
uniprot id: A0A7D4PDK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

349967:HRD69 RS11700
gene id: 349967:HRD69_RS11700
uniprot id: A0A7D4PC06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.
messages: Membrane
messages: Required for nicotinamide riboside transport across the inner membrane.

349967:HRD69 RS16065
gene id: 349967:HRD69_RS16065
uniprot id: A0A7D4PSV2
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS19425
gene id: 349967:HRD69_RS19425
uniprot id: A0A7D4SXY7
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS10820
gene id: 349967:HRD69_RS10820
uniprot id: A0A7D4T2D3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

349967:HRD69 RS03490
gene id: 349967:HRD69_RS03490
uniprot id: A0A7D4T5E9
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Cell membrane
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

349967:HRD69 RS20405
gene id: 349967:HRD69_RS20405
uniprot id: A0A7D4PP85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YdjC deacetylase family. ChbG subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the degradation of chitin. ChbG is essential for growth on the acetylated chitooligosaccharides chitobiose and chitotriose but is dispensable for growth on cellobiose and chitosan dimer, the deacetylated form of chitobiose. Deacetylation of chitobiose-6-P and chitotriose-6-P is necessary for both the activation of the chb promoter by the regulatory protein ChbR and the hydrolysis of phosphorylated beta-glucosides by the phospho-beta-glucosidase ChbF. Catalyzes the removal of only one acetyl group from chitobiose-6-P to yield monoacetylchitobiose-6-P, the inducer of ChbR and the substrate of ChbF.

349967:HRD69 RS17240
gene id: 349967:HRD69_RS17240
uniprot id: A0A7D4PCM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LpoB family.
messages: Cell outer membrane
messages: Interacts with PBP1b.
messages: Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b).

349967:HRD69 RS11710
gene id: 349967:HRD69_RS11710
uniprot id: A0A7D4P5W7
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

349967:HRD69 RS07645
gene id: 349967:HRD69_RS07645
uniprot id: A0A7D4T1P6
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

349967:HRD69 RS03665
gene id: 349967:HRD69_RS03665
uniprot id: A0A7D4U0W3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

349967:HRD69 RS07680
gene id: 349967:HRD69_RS07680
uniprot id: A0A7D4U0A6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Part of an enzyme complex containing four subunits: a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD).

349967:HRD69 RS12880
gene id: 349967:HRD69_RS12880
uniprot id: A0A7D4PBA6
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS08390
gene id: 349967:HRD69_RS08390
uniprot id: A0A7D4P3B3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. AI-2 autoinducer porter (TC 3.A.1.2.8) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).

349967:HRD69 RS17435
gene id: 349967:HRD69_RS17435
uniprot id: A0A7D4T931
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxL/LpxM/LpxP family.
messages: Catalyzes the transfer of an acyl chain from an acyl-[acyl-carrier-protein] (ACP) to a Kdo(2)-lipid IV(A) to form a Kdo(2)-(acyl)-lipid IV(A).
messages: Cell inner membrane

349967:HRD69 RS12415
gene id: 349967:HRD69_RS12415
uniprot id: A0A7D4TKX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0194 family.
messages: Periplasm

349967:HRD69 RS07935
gene id: 349967:HRD69_RS07935
uniprot id: A0A7D4P4U5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.
messages: Homodimer.

349967:HRD69 RS15725
gene id: 349967:HRD69_RS15725
uniprot id: A0A7D4P6U8
names: Similarity
messages: Belongs to the DDAH family.

349967:HRD69 RS03495
gene id: 349967:HRD69_RS03495
uniprot id: A0A7D4SY91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
messages: Cell inner membrane

349967:HRD69 RS01530
gene id: 349967:HRD69_RS01530
uniprot id: A0A7D4P3B7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial microcompartment
messages: Belongs to the EutC family.
messages: Binds between the large and small subunits.
messages: Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.
messages: The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.

349967:HRD69 RS03050
gene id: 349967:HRD69_RS03050
uniprot id: A0A7D4T0W9
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

349967:HRD69 RS18255
gene id: 349967:HRD69_RS18255
uniprot id: A0A7D4P559
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

349967:HRD69 RS11885
gene id: 349967:HRD69_RS11885
uniprot id: A0A7D4TZB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: Composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

349967:HRD69 RS06675
gene id: 349967:HRD69_RS06675
uniprot id: A0A7D4U5G9
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 4 family.
messages: Binds 1 NAD(+) per subunit.

349967:HRD69 RS01655
gene id: 349967:HRD69_RS01655
uniprot id: A0A7D4PDF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Cell inner membrane

349967:HRD69 RS09515
gene id: 349967:HRD69_RS09515
uniprot id: A0A7D4PLS0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS00455
gene id: 349967:HRD69_RS00455
uniprot id: A0A7D4TKH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family. QueF type 2 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm
messages: Homodimer.

349967:HRD69 RS00095
gene id: 349967:HRD69_RS00095
uniprot id: A0A7D4TKB5
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Electron transport system for the ribonucleotide reductase system NrdEF.

349967:HRD69 RS03700
gene id: 349967:HRD69_RS03700
uniprot id: A0A7D4P2C3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

349967:HRD69 RS07215
gene id: 349967:HRD69_RS07215
uniprot id: A0A7D4U220
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell inner membrane
messages: Component of the type II secretion system inner membrane complex required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
messages: Membrane

349967:HRD69 RS17375
gene id: 349967:HRD69_RS17375
uniprot id: A0A7D4P4Z5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

349967:HRD69 RS16415
gene id: 349967:HRD69_RS16415
uniprot id: A0A7D4T3D3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
messages: Cell membrane

349967:HRD69 RS00620
gene id: 349967:HRD69_RS00620
uniprot id: A0A7D4P8S2
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

349967:HRD69 RS13725
gene id: 349967:HRD69_RS13725
uniprot id: A0A7D4T7G7
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliO/MopB family.
messages: Cell membrane

349967:HRD69 RS16160
gene id: 349967:HRD69_RS16160
uniprot id: A0A7D4P6Y4
names: Function
names: Similarity
messages: Belongs to the anhydro-N-acetylmuramic acid kinase family.
messages: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.

349967:HRD69 RS04360
gene id: 349967:HRD69_RS04360
uniprot id: A0A7D4U164
names: Function
names: Similarity
messages: Belongs to the GppA/Ppx family. GppA subfamily.
messages: Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.

349967:HRD69 RS06230
gene id: 349967:HRD69_RS06230
uniprot id: A0A7D4P1H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family. Pit subfamily.
messages: Membrane

349967:HRD69 RS07205
gene id: 349967:HRD69_RS07205
uniprot id: A0A7D4TJN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP H family.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS15165
gene id: 349967:HRD69_RS15165
uniprot id: A0A7D4PSK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

349967:HRD69 RS03295
gene id: 349967:HRD69_RS03295
uniprot id: A0A7D4U0R0
names: Function
names: Similarity
names: Subunit
messages: Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters.
messages: Belongs to the transcriptional regulatory Fis family.
messages: Homodimer.

349967:HRD69 RS10455
gene id: 349967:HRD69_RS10455
uniprot id: A0A7D4P5M2
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaved by autocatalysis into a large and a small subunit.
messages: This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.

349967:HRD69 RS07705
gene id: 349967:HRD69_RS07705
uniprot id: A0A7D4P4S9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

349967:HRD69 RS04830
gene id: 349967:HRD69_RS04830
uniprot id: A0A7D4TXD4
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

349967:HRD69 RS08845
gene id: 349967:HRD69_RS08845
uniprot id: A0A7D4PLL0
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

349967:HRD69 RS19520
gene id: 349967:HRD69_RS19520
uniprot id: A0A7D4PUD6
names: Similarity
messages: Belongs to the GppA/Ppx family.

349967:HRD69 RS18000
gene id: 349967:HRD69_RS18000
uniprot id: A0A7D4U4X0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS02675
gene id: 349967:HRD69_RS02675
uniprot id: A0A7D4P6G6
names: Similarity
messages: Belongs to the VgrG protein family.

349967:HRD69 RS01915
gene id: 349967:HRD69_RS01915
uniprot id: A0A7D4TEU3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

349967:HRD69 RS06680
gene id: 349967:HRD69_RS06680
uniprot id: A0A7D4P4F8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

349967:HRD69 RS13655
gene id: 349967:HRD69_RS13655
uniprot id: A0A7D4P3C3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

349967:HRD69 RS06400
gene id: 349967:HRD69_RS06400
uniprot id: A0A7D4TM46
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS05710
gene id: 349967:HRD69_RS05710
uniprot id: A0A7D4PA59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS13255
gene id: 349967:HRD69_RS13255
uniprot id: A0A7D4TNU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.

349967:HRD69 RS11635
gene id: 349967:HRD69_RS11635
uniprot id: A0A7D4T716
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

349967:HRD69 RS18745
gene id: 349967:HRD69_RS18745
uniprot id: A0A7D4TQJ1
names: Function
names: Similarity
messages: Belongs to the CcmH/CycL/Ccl2/NrfF family.
messages: Possible subunit of a heme lyase.

349967:HRD69 RS07695
gene id: 349967:HRD69_RS07695
uniprot id: A0A7D4PAW9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.

349967:HRD69 RS06845
gene id: 349967:HRD69_RS06845
uniprot id: A0A7D4T632
names: Function
names: Similarity
messages: Belongs to the bacterioferritin family.
messages: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.

349967:HRD69 RS15990
gene id: 349967:HRD69_RS15990
uniprot id: A0A7D4TPK5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.
messages: Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin.

349967:HRD69 RS16700
gene id: 349967:HRD69_RS16700
uniprot id: A0A7D4P9J4
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the PHP family.
messages: Binds 3 Zn(2+) ions per subunit.
messages: Homotrimer.

349967:HRD69 RS07470
gene id: 349967:HRD69_RS07470
uniprot id: A0A7D4PAQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS00960
gene id: 349967:HRD69_RS00960
uniprot id: A0A7D4P1U3
names: Similarity
messages: Belongs to the prokaryotic GSH synthase family.

349967:HRD69 RS01215
gene id: 349967:HRD69_RS01215
uniprot id: A0A7D4PN95
names: Similarity
messages: Belongs to the VgrG protein family.

349967:HRD69 RS00935
gene id: 349967:HRD69_RS00935
uniprot id: A0A7D4P0F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS17765
gene id: 349967:HRD69_RS17765
uniprot id: A0A7D4TQ95
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.

349967:HRD69 RS00265
gene id: 349967:HRD69_RS00265
uniprot id: A0A7D4TVX1
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

349967:HRD69 RS03405
gene id: 349967:HRD69_RS03405
uniprot id: A0A7D4U0S0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

349967:HRD69 RS00975
gene id: 349967:HRD69_RS00975
uniprot id: A0A7D4PDA0
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily.

349967:HRD69 RS10510
gene id: 349967:HRD69_RS10510
uniprot id: A0A7D4T6U3
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

349967:HRD69 RS19275
gene id: 349967:HRD69_RS19275
uniprot id: A0A7D4U5Q2
names: Function
names: Similarity
messages: Belongs to the NanE family.
messages: Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).

349967:HRD69 RS07485
gene id: 349967:HRD69_RS07485
uniprot id: A0A7D4P348
names: Similarity
messages: Belongs to the ner transcriptional regulatory family.

349967:HRD69 RS19465
gene id: 349967:HRD69_RS19465
uniprot id: A0A7D4U219
names: Similarity
messages: Belongs to the ArsC family.

349967:HRD69 RS19340
gene id: 349967:HRD69_RS19340
uniprot id: A0A7D4T8K9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.
messages: Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
messages: Component of the periplasmic nitrate reductase NapAB complex composed of NapA and NapB.
messages: Periplasm
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

349967:HRD69 RS09890
gene id: 349967:HRD69_RS09890
uniprot id: A0A7D4TN12
names: Subcellular Location Annotation
messages: Cytoplasm

349967:HRD69 RS16890
gene id: 349967:HRD69_RS16890
uniprot id: A0A7D4PUX4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Transforms N(2)-succinylglutamate into succinate and glutamate.

349967:HRD69 RS07565
gene id: 349967:HRD69_RS07565
uniprot id: A0A7D4TJU8
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

349967:HRD69 RS03955
gene id: 349967:HRD69_RS03955
uniprot id: A0A7D4P2D5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).

349967:HRD69 RS01065
gene id: 349967:HRD69_RS01065
uniprot id: A0A7D4P1U8
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

349967:HRD69 RS08285
gene id: 349967:HRD69_RS08285
uniprot id: A0A7D4PF73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptF/LptG family.
messages: Cell inner membrane
messages: Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).
messages: Membrane
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

349967:HRD69 RS16940
gene id: 349967:HRD69_RS16940
uniprot id: A0A7D4PPN3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS13005
gene id: 349967:HRD69_RS13005
uniprot id: A0A7D4P477
names: Cofactor
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.

349967:HRD69 RS01470
gene id: 349967:HRD69_RS01470
uniprot id: A0A7D4T0K9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

349967:HRD69 RS10075
gene id: 349967:HRD69_RS10075
uniprot id: A0A7D4SYB8
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

349967:HRD69 RS13560
gene id: 349967:HRD69_RS13560
uniprot id: A0A7D4P8T7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FlhC family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.
messages: Heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers.

349967:HRD69 RS14325
gene id: 349967:HRD69_RS14325
uniprot id: A0A7D4PCR7
names: Subcellular Location Annotation
messages: Cytoplasm

349967:HRD69 RS19960
gene id: 349967:HRD69_RS19960
uniprot id: A0A7D4T422
names: Function
names: Similarity
messages: Belongs to the heat shock protein 70 family.
messages: Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU.

349967:HRD69 RS13770
gene id: 349967:HRD69_RS13770
uniprot id: A0A7D4P8V7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The M ring is integral to the inner membrane of the cell and may be connected to the flagellar rod via the S ring. The S (supramembrane ring) lies just distal to the M ring. The L and P rings lie in the outer membrane and the periplasmic space, respectively.

349967:HRD69 RS03785
gene id: 349967:HRD69_RS03785
uniprot id: A0A7D4TX15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

349967:HRD69 RS01575
gene id: 349967:HRD69_RS01575
uniprot id: A0A7D4TKR2
names: Similarity
messages: Belongs to the HypD family.

349967:HRD69 RS09010
gene id: 349967:HRD69_RS09010
uniprot id: A0A7D4P258
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homodimer.

349967:HRD69 RS06785
gene id: 349967:HRD69_RS06785
uniprot id: A0A7D4PAI6
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

349967:HRD69 RS04295
gene id: 349967:HRD69_RS04295
uniprot id: A0A7D4P2F9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 56 family.
messages: Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis.
messages: Cell inner membrane

349967:HRD69 RS18630
gene id: 349967:HRD69_RS18630
uniprot id: A0A7D4TQH8
names: Similarity
messages: Belongs to the myoviridae tail sheath protein family.

349967:HRD69 RS16480
gene id: 349967:HRD69_RS16480
uniprot id: A0A7D4P707
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

349967:HRD69 RS18375
gene id: 349967:HRD69_RS18375
uniprot id: A0A7D4PHJ8
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TorC/TorY family.
messages: Binds 5 heme groups per subunit.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS09520
gene id: 349967:HRD69_RS09520
uniprot id: A0A7D4SWB1
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

349967:HRD69 RS15260
gene id: 349967:HRD69_RS15260
uniprot id: A0A7D4PCZ7
names: Similarity
messages: Belongs to the peptidase S49 family.

349967:HRD69 RS09955
gene id: 349967:HRD69_RS09955
uniprot id: A0A7D4P3N9
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS03655
gene id: 349967:HRD69_RS03655
uniprot id: A0A7D4TX05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rsd/AlgQ family.
messages: Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase.
messages: Cytoplasm
messages: Interacts with RpoD.

349967:HRD69 RS05785
gene id: 349967:HRD69_RS05785
uniprot id: A0A7D4TXM5
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Homodimer.
messages: Membrane

349967:HRD69 RS09085
gene id: 349967:HRD69_RS09085
uniprot id: A0A7D4TMU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

349967:HRD69 RS18485
gene id: 349967:HRD69_RS18485
uniprot id: A0A7D4PNQ9
names: Similarity
messages: Belongs to the UPF0352 family.

349967:HRD69 RS03485
gene id: 349967:HRD69_RS03485
uniprot id: A0A7D4TLB4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.
messages: Cell inner membrane
messages: Membrane
messages: Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents.

349967:HRD69 RS01550
gene id: 349967:HRD69_RS01550
uniprot id: A0A7D4PDE8
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

349967:HRD69 RS17210
gene id: 349967:HRD69_RS17210
uniprot id: A0A7D4TIM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

349967:HRD69 RS08375
gene id: 349967:HRD69_RS08375
uniprot id: A0A7D4PB70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 2 family.
messages: Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases.
messages: Periplasm
messages: The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).

349967:HRD69 RS12100
gene id: 349967:HRD69_RS12100
uniprot id: A0A7D4TKU7
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

349967:HRD69 RS07820
gene id: 349967:HRD69_RS07820
uniprot id: A0A7D4PB26
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

349967:HRD69 RS04030
gene id: 349967:HRD69_RS04030
uniprot id: A0A7D4U0Z5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).

349967:HRD69 RS02190
gene id: 349967:HRD69_RS02190
uniprot id: A0A7D4P8A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space.
messages: In the C-terminal section; belongs to the glycosyl hydrolase 73 family.
messages: In the N-terminal section; belongs to the FlgJ family.
messages: Periplasm

349967:HRD69 RS00350
gene id: 349967:HRD69_RS00350
uniprot id: A0A7D4T0E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

349967:HRD69 RS12590
gene id: 349967:HRD69_RS12590
uniprot id: A0A7D4PG32
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

349967:HRD69 RS04465
gene id: 349967:HRD69_RS04465
uniprot id: A0A7D4TFB2
names: Similarity
messages: Belongs to the colicins ColE2/ColE8/ColE9 and pyocins S1/S2 family.

349967:HRD69 RS04425
gene id: 349967:HRD69_RS04425
uniprot id: A0A7D4PQS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

349967:HRD69 RS04100
gene id: 349967:HRD69_RS04100
uniprot id: A0A7D4T125
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell inner membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

349967:HRD69 RS06980
gene id: 349967:HRD69_RS06980
uniprot id: A0A7D4P9R1
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

349967:HRD69 RS18980
gene id: 349967:HRD69_RS18980
uniprot id: A0A7D4TMU7
names: Function
names: Similarity
messages: Belongs to the CsgG family.
messages: May be involved in the biogenesis of curli organelles.

349967:HRD69 RS07920
gene id: 349967:HRD69_RS07920
uniprot id: A0A7D4P9Y5
names: Function
names: Similarity
messages: Belongs to the MurCDEF family. Mpl subfamily.
messages: Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramate.

349967:HRD69 RS02430
gene id: 349967:HRD69_RS02430
uniprot id: A0A7D4U0D7
names: Similarity
messages: Belongs to the amidinotransferase family.

349967:HRD69 RS11285
gene id: 349967:HRD69_RS11285
uniprot id: A0A7D4TZ53
names: Similarity
messages: Belongs to the DNA polymerase HolA subunit family.

349967:HRD69 RS06525
gene id: 349967:HRD69_RS06525
uniprot id: A0A7D4U1V6
names: Subcellular Location Annotation
messages: Cell inner membrane

349967:HRD69 RS08135
gene id: 349967:HRD69_RS08135
uniprot id: A0A7D4P1W5
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

349967:HRD69 RS07570
gene id: 349967:HRD69_RS07570
uniprot id: A0A7D4TY82
names: Similarity
messages: Belongs to the CdaR family.

349967:HRD69 RS20000
gene id: 349967:HRD69_RS20000
uniprot id: A0A7D4U365
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family. RcnA subfamily.
messages: Cell membrane
messages: Efflux system for nickel and cobalt.
messages: Membrane

349967:HRD69 RS04800
gene id: 349967:HRD69_RS04800
uniprot id: A0A7D4SUT1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

349967:HRD69 RS11965
gene id: 349967:HRD69_RS11965
uniprot id: A0A7D4T2N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ElaB/YgaM/YqjD family.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS14980
gene id: 349967:HRD69_RS14980
uniprot id: A0A7D4TLK9
names: Similarity
messages: Belongs to the Nudix hydrolase family.

349967:HRD69 RS12070
gene id: 349967:HRD69_RS12070
uniprot id: A0A7D4SWP3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

349967:HRD69 RS04630
gene id: 349967:HRD69_RS04630
uniprot id: A0A7D4U183
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

349967:HRD69 RS11295
gene id: 349967:HRD69_RS11295
uniprot id: A0A7D4U157
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

349967:HRD69 RS20240
gene id: 349967:HRD69_RS20240
uniprot id: A0A7D4P5J7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamE family.
messages: Cell outer membrane
messages: Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

349967:HRD69 RS01815
gene id: 349967:HRD69_RS01815
uniprot id: A0A7D4TIA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS14725
gene id: 349967:HRD69_RS14725
uniprot id: A0A7D4T7M5
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

349967:HRD69 RS15025
gene id: 349967:HRD69_RS15025
uniprot id: A0A7D4P3N1
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the RssB family.
messages: Binds to RpoS.
messages: Phosphorylated. Phosphorylation stimulates the interaction with RpoS and, therefore, the proteolysis of RpoS.
messages: Regulates the turnover of the sigma S factor (RpoS) by promoting its proteolysis in exponentially growing cells. Acts by binding and delivering RpoS to the ClpXP protease. RssB is not co-degraded with RpoS, but is released from the complex and can initiate a new cycle of RpoS recognition and degradation.

349967:HRD69 RS15365
gene id: 349967:HRD69_RS15365
uniprot id: A0A7D4PBZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNR ribonuclease family. RNase II subfamily.
messages: Cytoplasm
messages: Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction.

349967:HRD69 RS11580
gene id: 349967:HRD69_RS11580
uniprot id: A0A7D4P3Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth.

349967:HRD69 RS16435
gene id: 349967:HRD69_RS16435
uniprot id: A0A7D4TLZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (BtuD), two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).

349967:HRD69 RS00425
gene id: 349967:HRD69_RS00425
uniprot id: A0A7D4PPR3
names: Similarity
messages: Belongs to the UPF0325 family.

349967:HRD69 RS17040
gene id: 349967:HRD69_RS17040
uniprot id: A0A7D4PCK7
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

349967:HRD69 RS14840
gene id: 349967:HRD69_RS14840
uniprot id: A0A7D4T343
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

349967:HRD69 RS10080
gene id: 349967:HRD69_RS10080
uniprot id: A0A7D4P5J4
names: Subcellular Location Annotation
messages: Cytoplasm

349967:HRD69 RS05700
gene id: 349967:HRD69_RS05700
uniprot id: A0A7D4P1B7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS16770
gene id: 349967:HRD69_RS16770
uniprot id: A0A7D4TII2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

349967:HRD69 RS17915
gene id: 349967:HRD69_RS17915
uniprot id: A0A7D4PDU3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family. MukB subfamily.
messages: Homodimerization via its hinge domain. Binds to DNA via its C-terminal region. Interacts, and probably forms a ternary complex, with MukE and MukF via its C-terminal region. The complex formation is stimulated by calcium or magnesium. Interacts with tubulin-related protein FtsZ.
messages: Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.
messages: The hinge domain, which separates the large intramolecular coiled coil regions, allows the homodimerization, forming a V-shaped homodimer.
messages: nucleoid

349967:HRD69 RS15870
gene id: 349967:HRD69_RS15870
uniprot id: A0A7D4SXD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.
messages: Membrane

349967:HRD69 RS19350
gene id: 349967:HRD69_RS19350
uniprot id: A0A7D4TJ63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NapF family.
messages: Could be involved in the maturation of NapA, the catalytic subunit of the periplasmic nitrate reductase, before its export into the periplasm.
messages: Cytoplasm
messages: Interacts with the cytoplasmic NapA precursor.

349967:HRD69 RS10725
gene id: 349967:HRD69_RS10725
uniprot id: A0A7D4TN72
names: Similarity
messages: Belongs to the Hha/YmoA/Cnu family.

349967:HRD69 RS16220
gene id: 349967:HRD69_RS16220
uniprot id: A0A7D4TLX7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase T family.
messages: Binds two Mg(2+) per subunit. The active form of the enzyme binds two Mg(2+) ions in its active site. The first Mg(2+) forms only one salt bridge with the protein.
messages: Homodimer.
messages: Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis.

349967:HRD69 RS02455
gene id: 349967:HRD69_RS02455
uniprot id: A0A7D4P6F2
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family.

349967:HRD69 RS17365
gene id: 349967:HRD69_RS17365
uniprot id: A0A7D4P9P0
names: Function
names: Similarity
messages: Belongs to the DUF177 domain family.
messages: Plays a role in synthesis, processing and/or stability of 23S rRNA.

349967:HRD69 RS00370
gene id: 349967:HRD69_RS00370
uniprot id: A0A7D4THY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

349967:HRD69 RS19955
gene id: 349967:HRD69_RS19955
uniprot id: A0A7D4SY02
names: Similarity
messages: Belongs to the adrenodoxin/putidaredoxin family.

349967:HRD69 RS02160
gene id: 349967:HRD69_RS02160
uniprot id: A0A7D4TEW0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FlhC family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.
messages: Heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers.

349967:HRD69 RS02195
gene id: 349967:HRD69_RS02195
uniprot id: A0A7D4P981
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgI family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

349967:HRD69 RS03425
gene id: 349967:HRD69_RS03425
uniprot id: A0A7D4P9I8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

349967:HRD69 RS12045
gene id: 349967:HRD69_RS12045
uniprot id: A0A7D4P418
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protease inhibitor I11 (ecotin) family.
messages: General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases.
messages: Homodimer.
messages: Periplasm

349967:HRD69 RS00180
gene id: 349967:HRD69_RS00180
uniprot id: A0A7D4P316
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

349967:HRD69 RS00925
gene id: 349967:HRD69_RS00925
uniprot id: A0A7D4TZU7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

349967:HRD69 RS13540
gene id: 349967:HRD69_RS13540
uniprot id: A0A7D4U1P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS10490
gene id: 349967:HRD69_RS10490
uniprot id: A0A7D4SWF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS12125
gene id: 349967:HRD69_RS12125
uniprot id: A0A7D4PB39
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.
messages: Methylates ribosomal protein uL3 on a specific glutamine residue.

349967:HRD69 RS11610
gene id: 349967:HRD69_RS11610
uniprot id: A0A7D4SWL7
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

349967:HRD69 RS08995
gene id: 349967:HRD69_RS08995
uniprot id: A0A7D4TYK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

349967:HRD69 RS06750
gene id: 349967:HRD69_RS06750
uniprot id: A0A7D4TY19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

349967:HRD69 RS08435
gene id: 349967:HRD69_RS08435
uniprot id: A0A7D4TMN5
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

349967:HRD69 RS16675
gene id: 349967:HRD69_RS16675
uniprot id: A0A7D4U2D6
names: Similarity
messages: Belongs to the UPF0502 family.

349967:HRD69 RS15090
gene id: 349967:HRD69_RS15090
uniprot id: A0A7D4P509
names: Similarity
messages: Belongs to the UPF0263 family.

349967:HRD69 RS04045
gene id: 349967:HRD69_RS04045
uniprot id: A0A7D4P8V2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoH subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.

349967:HRD69 RS10985
gene id: 349967:HRD69_RS10985
uniprot id: A0A7D4P8C9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

349967:HRD69 RS09400
gene id: 349967:HRD69_RS09400
uniprot id: A0A7D4PLR5
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

349967:HRD69 RS20015
gene id: 349967:HRD69_RS20015
uniprot id: A0A7D4PDC1
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS09970
gene id: 349967:HRD69_RS09970
uniprot id: A0A7D4PFK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

349967:HRD69 RS14315
gene id: 349967:HRD69_RS14315
uniprot id: A0A7D4P3H2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lipid A palmitoyltransferase family.
messages: Cell outer membrane
messages: Homodimer.
messages: Transfers a fatty acid residue from the sn-1 position of a phospholipid to the N-linked hydroxyfatty acid chain on the proximal unit of lipid A or its precursors.

349967:HRD69 RS02145
gene id: 349967:HRD69_RS02145
uniprot id: A0A7D4T0P9
names: Function
messages: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY.

349967:HRD69 RS07030
gene id: 349967:HRD69_RS07030
uniprot id: A0A7D4SV81
names: Similarity
messages: Belongs to the Smg family.

349967:HRD69 RS19655
gene id: 349967:HRD69_RS19655
uniprot id: A0A7D4TQQ9
names: Similarity
names: Subunit
messages: Belongs to the SIS family. GutQ/KpsF subfamily.
messages: Homotetramer.

349967:HRD69 RS18305
gene id: 349967:HRD69_RS18305
uniprot id: A0A7D4TIX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

349967:HRD69 RS19315
gene id: 349967:HRD69_RS19315
uniprot id: A0A7D4PP01
names: Similarity
messages: Belongs to the UPF0178 family.

349967:HRD69 RS06415
gene id: 349967:HRD69_RS06415
uniprot id: A0A7D4TJE9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

349967:HRD69 RS05665
gene id: 349967:HRD69_RS05665
uniprot id: A0A7D4TLX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAE transporter (TC 2.A.81) family. YidE subfamily.
messages: Cell membrane

349967:HRD69 RS03965
gene id: 349967:HRD69_RS03965
uniprot id: A0A7D4PQM9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import. Binds G3P.
messages: The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).

349967:HRD69 RS06925
gene id: 349967:HRD69_RS06925
uniprot id: A0A7D4SVW9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

349967:HRD69 RS16030
gene id: 349967:HRD69_RS16030
uniprot id: A0A7D4U278
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this atypical 2-Cys peroxiredoxin, C(R) is present in the same subunit to form an intramolecular disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

349967:HRD69 RS08020
gene id: 349967:HRD69_RS08020
uniprot id: A0A7D4P9Z5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

349967:HRD69 RS08215
gene id: 349967:HRD69_RS08215
uniprot id: A0A7D4TK07
names: Function
names: Similarity
messages: Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.

349967:HRD69 RS14360
gene id: 349967:HRD69_RS14360
uniprot id: A0A7D4PMR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Probably functions as a manganese efflux pump.

349967:HRD69 RS09435
gene id: 349967:HRD69_RS09435
uniprot id: A0A7D4TGJ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

349967:HRD69 RS08395
gene id: 349967:HRD69_RS08395
uniprot id: A0A7D4PQG6
names: Similarity
messages: Belongs to the SorC transcriptional regulatory family.

349967:HRD69 RS04090
gene id: 349967:HRD69_RS04090
uniprot id: A0A7D4SVB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

349967:HRD69 RS05265
gene id: 349967:HRD69_RS05265
uniprot id: A0A7D4U1I5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.

349967:HRD69 RS05510
gene id: 349967:HRD69_RS05510
uniprot id: A0A7D4P706
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

349967:HRD69 RS17950
gene id: 349967:HRD69_RS17950
uniprot id: A0A7D4PNL2
names: Similarity
messages: Belongs to the UPF0434 family.

349967:HRD69 RS11880
gene id: 349967:HRD69_RS11880
uniprot id: A0A7D4TKT2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

349967:HRD69 RS09730
gene id: 349967:HRD69_RS09730
uniprot id: A0A7D4PQX0
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

349967:HRD69 RS19855
gene id: 349967:HRD69_RS19855
uniprot id: A0A7D4T413
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

349967:HRD69 RS14615
gene id: 349967:HRD69_RS14615
uniprot id: A0A7D4T7L8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PqiA family.
messages: Component of a transport pathway that contributes to membrane integrity.
messages: Membrane

349967:HRD69 RS07780
gene id: 349967:HRD69_RS07780
uniprot id: A0A7D4TG52
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

349967:HRD69 RS04820
gene id: 349967:HRD69_RS04820
uniprot id: A0A7D4TFD2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

349967:HRD69 RS12820
gene id: 349967:HRD69_RS12820
uniprot id: A0A7D4SWU8
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS12300
gene id: 349967:HRD69_RS12300
uniprot id: A0A7D4T768
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.

349967:HRD69 RS09680
gene id: 349967:HRD69_RS09680
uniprot id: A0A7D4U0S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial export usher family.
messages: Cell outer membrane
messages: Membrane

349967:HRD69 RS06360
gene id: 349967:HRD69_RS06360
uniprot id: A0A7D4P2V0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

349967:HRD69 RS12675
gene id: 349967:HRD69_RS12675
uniprot id: A0A7D4P649
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS08915
gene id: 349967:HRD69_RS08915
uniprot id: A0A7D4P7U9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptD family.
messages: Cell outer membrane
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptE and LptA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.

349967:HRD69 RS00980
gene id: 349967:HRD69_RS00980
uniprot id: A0A7D4PJR4
names: Similarity
messages: Belongs to the agmatine deiminase family.

349967:HRD69 RS02080
gene id: 349967:HRD69_RS02080
uniprot id: A0A7D4P6D4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

349967:HRD69 RS06430
gene id: 349967:HRD69_RS06430
uniprot id: A0A7D4U006
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

349967:HRD69 RS19515
gene id: 349967:HRD69_RS19515
uniprot id: A0A7D4PTU7
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

349967:HRD69 RS14835
gene id: 349967:HRD69_RS14835
uniprot id: A0A7D4SWT0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

349967:HRD69 RS03440
gene id: 349967:HRD69_RS03440
uniprot id: A0A7D4P2A5
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

349967:HRD69 RS18550
gene id: 349967:HRD69_RS18550
uniprot id: A0A7D4U2U3
names: Similarity
messages: Belongs to the ner transcriptional regulatory family.

349967:HRD69 RS17425
gene id: 349967:HRD69_RS17425
uniprot id: A0A7D4TIP5
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

349967:HRD69 RS14390
gene id: 349967:HRD69_RS14390
uniprot id: A0A7D4THZ2
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

349967:HRD69 RS12955
gene id: 349967:HRD69_RS12955
uniprot id: A0A7D4TL15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

349967:HRD69 RS19480
gene id: 349967:HRD69_RS19480
uniprot id: A0A7D4U321
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

349967:HRD69 RS01600
gene id: 349967:HRD69_RS01600
uniprot id: A0A7D4U058
names: Similarity
messages: Belongs to the peptidase A31 family.

349967:HRD69 RS05620
gene id: 349967:HRD69_RS05620
uniprot id: A0A7D4P467
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

349967:HRD69 RS09295
gene id: 349967:HRD69_RS09295
uniprot id: A0A7D4SW95
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterooctamer of four alpha and four beta chains arranged as a tetramer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

349967:HRD69 RS20170
gene id: 349967:HRD69_RS20170
uniprot id: A0A7D4SY22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

349967:HRD69 RS16825
gene id: 349967:HRD69_RS16825
uniprot id: A0A7D4PT15
names: Subunit
messages: Monomer.

349967:HRD69 RS06970
gene id: 349967:HRD69_RS06970
uniprot id: A0A7D4U052
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

349967:HRD69 RS06890
gene id: 349967:HRD69_RS06890
uniprot id: A0A7D4P795
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

349967:HRD69 RS06425
gene id: 349967:HRD69_RS06425
uniprot id: A0A7D4U1U6
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

349967:HRD69 RS10810
gene id: 349967:HRD69_RS10810
uniprot id: A0A7D4SWH6
names: Subcellular Location Annotation
messages: Cell inner membrane

349967:HRD69 RS13075
gene id: 349967:HRD69_RS13075
uniprot id: A0A7D4U1L6
names: Similarity
messages: Belongs to the EutP/PduV family.

349967:HRD69 RS03260
gene id: 349967:HRD69_RS03260
uniprot id: A0A7D4SUH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

349967:HRD69 RS15140
gene id: 349967:HRD69_RS15140
uniprot id: A0A7D4PBX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

349967:HRD69 RS12400
gene id: 349967:HRD69_RS12400
uniprot id: A0A7D4TNL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS09170
gene id: 349967:HRD69_RS09170
uniprot id: A0A7D4SW90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS01380
gene id: 349967:HRD69_RS01380
uniprot id: A0A7D4TEP9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

349967:HRD69 RS15795
gene id: 349967:HRD69_RS15795
uniprot id: A0A7D4TLR7
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS00760
gene id: 349967:HRD69_RS00760
uniprot id: A0A7D4PD82
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD, in which XerC interacts with XerD via its C-terminal region, XerD interacts with XerC via its C-terminal region and so on.
messages: FtsK may regulate the catalytic switch between XerC and XerD in the heterotetrameric complex during the two steps of the recombination process.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerC binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. In the complex XerD specifically exchanges the bottom DNA strands.

349967:HRD69 RS02855
gene id: 349967:HRD69_RS02855
uniprot id: A0A7D4T572
names: Similarity
messages: Belongs to the GST superfamily. HSP26 family.

349967:HRD69 RS16835
gene id: 349967:HRD69_RS16835
uniprot id: A0A7D4PTQ8
names: Similarity
messages: Belongs to the LacAB/RpiB family.

349967:HRD69 RS11215
gene id: 349967:HRD69_RS11215
uniprot id: A0A7D4P8E3
names: Subcellular Location Annotation
messages: Cytoplasm

349967:HRD69 RS14370
gene id: 349967:HRD69_RS14370
uniprot id: A0A7D4SWP9
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS08960
gene id: 349967:HRD69_RS08960
uniprot id: A0A7D4SVM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Periplasm

349967:HRD69 RS04865
gene id: 349967:HRD69_RS04865
uniprot id: A0A7D4P3Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic sulfate-binding protein family.
messages: Periplasm

349967:HRD69 RS05170
gene id: 349967:HRD69_RS05170
uniprot id: A0A7D4TZP8
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

349967:HRD69 RS03465
gene id: 349967:HRD69_RS03465
uniprot id: A0A7D4SV75
names: Function
names: Similarity
messages: Belongs to the Dus family. DusA subfamily.
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs.

349967:HRD69 RS08645
gene id: 349967:HRD69_RS08645
uniprot id: A0A7D4T1Y7
names: Similarity
messages: Belongs to the Smp family.

349967:HRD69 RS04535
gene id: 349967:HRD69_RS04535
uniprot id: A0A7D4PQT4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS02040
gene id: 349967:HRD69_RS02040
uniprot id: A0A7D4TEV1
names: Function
names: Similarity
messages: Belongs to the FliK family.
messages: Controls the length of the flagellar hook.

349967:HRD69 RS11890
gene id: 349967:HRD69_RS11890
uniprot id: A0A7D4U3C5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

349967:HRD69 RS03640
gene id: 349967:HRD69_RS03640
uniprot id: A0A7D4T5F7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

349967:HRD69 RS10035
gene id: 349967:HRD69_RS10035
uniprot id: A0A7D4TYU5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

349967:HRD69 RS12935
gene id: 349967:HRD69_RS12935
uniprot id: A0A7D4T2S9
names: Similarity
messages: Belongs to the UDPGP type 2 family.

349967:HRD69 RS06915
gene id: 349967:HRD69_RS06915
uniprot id: A0A7D4PEX4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

349967:HRD69 RS08620
gene id: 349967:HRD69_RS08620
uniprot id: A0A7D4PRW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

349967:HRD69 RS03735
gene id: 349967:HRD69_RS03735
uniprot id: A0A7D4T111
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS09650
gene id: 349967:HRD69_RS09650
uniprot id: A0A7D4T6P1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoS subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.

349967:HRD69 RS20475
gene id: 349967:HRD69_RS20475
uniprot id: A0A7D4PDG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

349967:HRD69 RS10580
gene id: 349967:HRD69_RS10580
uniprot id: A0A7D4PSB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase bacterial subunit 4 family.
messages: Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
messages: Heterooctamer of two A chains, two B chains, two C chains and two D chains.
messages: Membrane

349967:HRD69 RS12335
gene id: 349967:HRD69_RS12335
uniprot id: A0A7D4PB55
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

349967:HRD69 RS15825
gene id: 349967:HRD69_RS15825
uniprot id: A0A7D4PD47
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS06655
gene id: 349967:HRD69_RS06655
uniprot id: A0A7D4PAH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. TsgA family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

349967:HRD69 RS13015
gene id: 349967:HRD69_RS13015
uniprot id: A0A7D4PST1
names: Cofactor
messages: Binds 2 Mg(2+) ions per monomer.

349967:HRD69 RS10265
gene id: 349967:HRD69_RS10265
uniprot id: A0A7D4PFL7
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: Homotetramer.
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

349967:HRD69 RS13300
gene id: 349967:HRD69_RS13300
uniprot id: A0A7D4P3A2
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS09020
gene id: 349967:HRD69_RS09020
uniprot id: A0A7D4PAF0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS17820
gene id: 349967:HRD69_RS17820
uniprot id: A0A7D4P788
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

349967:HRD69 RS17980
gene id: 349967:HRD69_RS17980
uniprot id: A0A7D4T8B0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

349967:HRD69 RS13650
gene id: 349967:HRD69_RS13650
uniprot id: A0A7D4U1Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

349967:HRD69 RS18020
gene id: 349967:HRD69_RS18020
uniprot id: A0A7D4PCU0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
messages: Cytoplasm
messages: Homodimer.

349967:HRD69 RS19895
gene id: 349967:HRD69_RS19895
uniprot id: A0A7D4P4Q1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RodZ family.
messages: Cell inner membrane
messages: Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis.
messages: The helix-turn-helix (HTH) motif in the cytoplasmic domain of the N-terminus is involved in the formation of spirals to maintain the rigid rod shape. As this protein is anchored in the cytoplasmic membrane, the HTH motif may contribute to protein-protein interactions to form the RodZ helix, which is localized beneath the cytoplasmic membrane. The C-terminal domain may be critical for determination of the rod shape by probably interacting with enzymes required for synthesis of the peptidoglycan layer, including PBPs in the periplasm.

349967:HRD69 RS15320
gene id: 349967:HRD69_RS15320
uniprot id: A0A7D4T368
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

349967:HRD69 RS05660
gene id: 349967:HRD69_RS05660
uniprot id: A0A7D4T1A9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent.
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Homodimer. Forms homomultimers of about 100-150 subunits at optimal growth temperatures. Conformation changes to oligomers at high temperatures or high ionic concentrations. The decrease in size of the multimers is accompanied by an increase in chaperone activity.
messages: The N- and C-terminal flexible termini are involved in oligomerization and in the binding of non-native substrate proteins, and are essential for chaperone activity.

349967:HRD69 RS08850
gene id: 349967:HRD69_RS08850
uniprot id: A0A7D4SW78
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
messages: Homodimer.

349967:HRD69 RS18125
gene id: 349967:HRD69_RS18125
uniprot id: A0A7D4PCV0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

349967:HRD69 RS17330
gene id: 349967:HRD69_RS17330
uniprot id: A0A7D4TM78
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

349967:HRD69 RS20090
gene id: 349967:HRD69_RS20090
uniprot id: A0A7D4TJC1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: In the N-terminal section; belongs to the FGAMS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.

349967:HRD69 RS17775
gene id: 349967:HRD69_RS17775
uniprot id: A0A7D4TIS4
names: Subcellular Location Annotation
messages: Cell inner membrane

349967:HRD69 RS14310
gene id: 349967:HRD69_RS14310
uniprot id: A0A7D4U1V1
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS10845
gene id: 349967:HRD69_RS10845
uniprot id: A0A7D4TKK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

349967:HRD69 RS17995
gene id: 349967:HRD69_RS17995
uniprot id: A0A7D4U1C4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

349967:HRD69 RS16170
gene id: 349967:HRD69_RS16170
uniprot id: A0A7D4PSW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SlyA family.
messages: Homodimer.
messages: Transcription regulator that can specifically activate or repress expression of target genes.

349967:HRD69 RS19680
gene id: 349967:HRD69_RS19680
uniprot id: A0A7D4U590
names: Cofactor
messages: Binds 3 heme c groups covalently per subunit.

349967:HRD69 RS16540
gene id: 349967:HRD69_RS16540
uniprot id: A0A7D4TIG4
names: Similarity
names: Subunit
messages: Belongs to the KHG/KDPG aldolase family.
messages: Homotrimer.

349967:HRD69 RS07190
gene id: 349967:HRD69_RS07190
uniprot id: A0A7D4TMC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP K family.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS16250
gene id: 349967:HRD69_RS16250
uniprot id: A0A7D4PD89
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS12280
gene id: 349967:HRD69_RS12280
uniprot id: A0A7D4SWB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 3 family.
messages: Periplasm

349967:HRD69 RS08255
gene id: 349967:HRD69_RS08255
uniprot id: A0A7D4P851
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

349967:HRD69 RS05850
gene id: 349967:HRD69_RS05850
uniprot id: A0A7D4SVP0
names: Cofactor
names: Function
messages: Binds 4 [4Fe-4S] clusters per subunit.
messages: The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers.

349967:HRD69 RS09850
gene id: 349967:HRD69_RS09850
uniprot id: A0A7D4P3N3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20 family.
messages: Binds 2 Zn(2+) ions per subunit.

349967:HRD69 RS15060
gene id: 349967:HRD69_RS15060
uniprot id: A0A7D4PT66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm

349967:HRD69 RS09095
gene id: 349967:HRD69_RS09095
uniprot id: A0A7D4TGG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).

349967:HRD69 RS04570
gene id: 349967:HRD69_RS04570
uniprot id: A0A7D4T5M1
names: Function
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.
messages: Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon.

349967:HRD69 RS02400
gene id: 349967:HRD69_RS02400
uniprot id: A0A7D4TR11
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS05000
gene id: 349967:HRD69_RS05000
uniprot id: A0A7D4SVI5
names: Similarity
messages: Belongs to the UPF0758 family. YicR subfamily.

349967:HRD69 RS04795
gene id: 349967:HRD69_RS04795
uniprot id: A0A7D4SVH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

349967:HRD69 RS18330
gene id: 349967:HRD69_RS18330
uniprot id: A0A7D4P4C7
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS08560
gene id: 349967:HRD69_RS08560
uniprot id: A0A7D4TGC4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS00100
gene id: 349967:HRD69_RS00100
uniprot id: A0A7D4T4M6
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

349967:HRD69 RS13515
gene id: 349967:HRD69_RS13515
uniprot id: A0A7D4T7F5
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 2 family.
messages: Binds 1 sodium ion per monomer.
messages: Binds 2 magnesium ions per monomer.
messages: Homotetramer.

349967:HRD69 RS18190
gene id: 349967:HRD69_RS18190
uniprot id: A0A7D4T8C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 3 family.
messages: Periplasm

349967:HRD69 RS06625
gene id: 349967:HRD69_RS06625
uniprot id: A0A7D4TJG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

349967:HRD69 RS08760
gene id: 349967:HRD69_RS08760
uniprot id: A0A7D4T6G4
names: Similarity
messages: Belongs to the UPF0246 family.

349967:HRD69 RS07675
gene id: 349967:HRD69_RS07675
uniprot id: A0A7D4U258
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

349967:HRD69 RS18710
gene id: 349967:HRD69_RS18710
uniprot id: A0A7D4PTM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
messages: Cytoplasm
messages: Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI).

349967:HRD69 RS04175
gene id: 349967:HRD69_RS04175
uniprot id: A0A7D4PP24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

349967:HRD69 RS09835
gene id: 349967:HRD69_RS09835
uniprot id: A0A7D4PBK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS07600
gene id: 349967:HRD69_RS07600
uniprot id: A0A7D4P7I5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbD subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.

349967:HRD69 RS16000
gene id: 349967:HRD69_RS16000
uniprot id: A0A7D4T921
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TtcA family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is chelated by three Cys residues, the fourth Fe has a free coordination site that may bind a sulfur atom transferred from the persulfide of IscS.
messages: Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
messages: Cytoplasm
messages: Homodimer.
messages: The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster.

349967:HRD69 RS09080
gene id: 349967:HRD69_RS09080
uniprot id: A0A7D4T213
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS03825
gene id: 349967:HRD69_RS03825
uniprot id: A0A7D4P8T4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24B family. Bacterial-type prolidase subfamily.
messages: Binds 2 manganese ions per subunit.
messages: Splits dipeptides with a prolyl residue in the C-terminal position.

349967:HRD69 RS12060
gene id: 349967:HRD69_RS12060
uniprot id: A0A7D4PFY4
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

349967:HRD69 RS00955
gene id: 349967:HRD69_RS00955
uniprot id: A0A7D4P382
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

349967:HRD69 RS16645
gene id: 349967:HRD69_RS16645
uniprot id: A0A7D4T807
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
messages: Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS08080
gene id: 349967:HRD69_RS08080
uniprot id: A0A7D4SW39
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.

349967:HRD69 RS16580
gene id: 349967:HRD69_RS16580
uniprot id: A0A7D4PDB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS05395
gene id: 349967:HRD69_RS05395
uniprot id: A0A7D4P194
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
messages: Cytoplasm

349967:HRD69 RS16305
gene id: 349967:HRD69_RS16305
uniprot id: A0A7D4SX58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine. Selenocysteine lyase activity is however unsure in vivo.
messages: Cytoplasm
messages: Homodimer. Interacts with SufE and the SufBCD complex composed of SufB, SufC and SufD. The interaction with SufE is required to mediate the direct transfer of the sulfur atom from the S-sulfanylcysteine.

349967:HRD69 RS17910
gene id: 349967:HRD69_RS17910
uniprot id: A0A7D4PCT1
names: Similarity
messages: Belongs to the YkuD family.

349967:HRD69 RS03265
gene id: 349967:HRD69_RS03265
uniprot id: A0A7D4T0Y7
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

349967:HRD69 RS14985
gene id: 349967:HRD69_RS14985
uniprot id: A0A7D4U093
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

349967:HRD69 RS06515
gene id: 349967:HRD69_RS06515
uniprot id: A0A7D4TJF7
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family. GreB subfamily.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length.

349967:HRD69 RS13670
gene id: 349967:HRD69_RS13670
uniprot id: A0A7D4P8U9
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

349967:HRD69 RS05820
gene id: 349967:HRD69_RS05820
uniprot id: A0A7D4P482
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

349967:HRD69 RS16075
gene id: 349967:HRD69_RS16075
uniprot id: A0A7D4PGX2
names: Similarity
messages: Belongs to the PspA/IM30 family.

349967:HRD69 RS04025
gene id: 349967:HRD69_RS04025
uniprot id: A0A7D4TX38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).

349967:HRD69 RS17010
gene id: 349967:HRD69_RS17010
uniprot id: A0A7D4SYG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

349967:HRD69 RS07120
gene id: 349967:HRD69_RS07120
uniprot id: A0A7D4PAL9
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

349967:HRD69 RS11875
gene id: 349967:HRD69_RS11875
uniprot id: A0A7D4TH37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

349967:HRD69 RS19850
gene id: 349967:HRD69_RS19850
uniprot id: A0A7D4SXZ0
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

349967:HRD69 RS09555
gene id: 349967:HRD69_RS09555
uniprot id: A0A7D4TYQ5
names: Function
names: Similarity
messages: Belongs to the precorrin methyltransferase family.
messages: In the C-terminal section; belongs to the precorrin methyltransferase family.
messages: In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
messages: Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.

349967:HRD69 RS10605
gene id: 349967:HRD69_RS10605
uniprot id: A0A7D4T2B9
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS15855
gene id: 349967:HRD69_RS15855
uniprot id: A0A7D4PTB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNT beta subunit family.
messages: Cell inner membrane
messages: Heterodimer of an alpha and a beta chain.
messages: Membrane
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

349967:HRD69 RS00900
gene id: 349967:HRD69_RS00900
uniprot id: A0A7D4TKK6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.
messages: Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS02325
gene id: 349967:HRD69_RS02325
uniprot id: A0A7D4P6E5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Cell membrane
messages: Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

349967:HRD69 RS13455
gene id: 349967:HRD69_RS13455
uniprot id: A0A7D4PS83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.
messages: Membrane

349967:HRD69 RS10110
gene id: 349967:HRD69_RS10110
uniprot id: A0A7D4PLV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

349967:HRD69 RS00630
gene id: 349967:HRD69_RS00630
uniprot id: A0A7D4P357
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

349967:HRD69 RS13765
gene id: 349967:HRD69_RS13765
uniprot id: A0A7D4PCM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Cell inner membrane
messages: FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

349967:HRD69 RS08670
gene id: 349967:HRD69_RS08670
uniprot id: A0A7D4TYI1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS04325
gene id: 349967:HRD69_RS04325
uniprot id: A0A7D4SUQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily.
messages: Catalyzes the four-electron oxidation of UDP-N-acetyl-D-mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N-acetylmannosaminuronic acid (UDP-ManNAcA).
messages: Homodimer.

349967:HRD69 RS17205
gene id: 349967:HRD69_RS17205
uniprot id: A0A7D4T846
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

349967:HRD69 RS17195
gene id: 349967:HRD69_RS17195
uniprot id: A0A7D4T3J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

349967:HRD69 RS11905
gene id: 349967:HRD69_RS11905
uniprot id: A0A7D4PB24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

349967:HRD69 RS15415
gene id: 349967:HRD69_RS15415
uniprot id: A0A7D4SXA0
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

349967:HRD69 RS17990
gene id: 349967:HRD69_RS17990
uniprot id: A0A7D4TMD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

349967:HRD69 RS00380
gene id: 349967:HRD69_RS00380
uniprot id: A0A7D4TZL5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
messages: Homodimer.

349967:HRD69 RS09030
gene id: 349967:HRD69_RS09030
uniprot id: A0A7D4T4B0
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

349967:HRD69 RS18240
gene id: 349967:HRD69_RS18240
uniprot id: A0A7D4P9U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAE transporter (TC 2.A.81) family. YbjL subfamily.
messages: Cell membrane

349967:HRD69 RS11220
gene id: 349967:HRD69_RS11220
uniprot id: A0A7D4P5T4
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

349967:HRD69 RS11575
gene id: 349967:HRD69_RS11575
uniprot id: A0A7D4P5W1
names: Cofactor
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: The heme is bound between the two transmembrane subunits.

349967:HRD69 RS06465
gene id: 349967:HRD69_RS06465
uniprot id: A0A7D4PPS6
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

349967:HRD69 RS20140
gene id: 349967:HRD69_RS20140
uniprot id: A0A7D4P5I9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

349967:HRD69 RS16350
gene id: 349967:HRD69_RS16350
uniprot id: A0A7D4U2B1
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

349967:HRD69 RS12155
gene id: 349967:HRD69_RS12155
uniprot id: A0A7D4PRT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the DAO family.
messages: In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family.

349967:HRD69 RS13760
gene id: 349967:HRD69_RS13760
uniprot id: A0A7D4PBI6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliH family.
messages: Cytoplasm
messages: Needed for flagellar regrowth and assembly.

349967:HRD69 RS04160
gene id: 349967:HRD69_RS04160
uniprot id: A0A7D4U5G4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phospholipase A1 family.
messages: Binds 1 Ca(2+) ion per monomer. In the dimeric form the Ca(2+) is bound by different amino acids with binding of each Ca(2+) shared with ligands coming from each monomer. The Ca(2+) ion may have a role in catalysis.
messages: Cell outer membrane
messages: Homodimer; dimerization is reversible, and the dimeric form is the active one.
messages: Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities.
messages: Membrane

349967:HRD69 RS02030
gene id: 349967:HRD69_RS02030
uniprot id: A0A7D4T4Z2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Cell inner membrane
messages: FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

349967:HRD69 RS02895
gene id: 349967:HRD69_RS02895
uniprot id: A0A7D4P9D4
names: Similarity
messages: Belongs to the BolA/IbaG family.

349967:HRD69 RS17095
gene id: 349967:HRD69_RS17095
uniprot id: A0A7D4T3H8
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS04990
gene id: 349967:HRD69_RS04990
uniprot id: A0A7D4PEH2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

349967:HRD69 RS11645
gene id: 349967:HRD69_RS11645
uniprot id: A0A7D4TKR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolQ, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

349967:HRD69 RS10360
gene id: 349967:HRD69_RS10360
uniprot id: A0A7D4PR11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)-dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility.
messages: Bacterial flagellum basal body
messages: Belongs to the YcgR family.
messages: Monomer. Interacts with the flagellar basal bodies.

349967:HRD69 RS09865
gene id: 349967:HRD69_RS09865
uniprot id: A0A7D4PFJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

349967:HRD69 RS09365
gene id: 349967:HRD69_RS09365
uniprot id: A0A7D4P7Y6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

349967:HRD69 RS20225
gene id: 349967:HRD69_RS20225
uniprot id: A0A7D4PEL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

349967:HRD69 RS12065
gene id: 349967:HRD69_RS12065
uniprot id: A0A7D4PM79
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. UbiG/COQ3 family.
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

349967:HRD69 RS00075
gene id: 349967:HRD69_RS00075
uniprot id: A0A7D4PJH4
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Asr family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Periplasm
messages: Proteolytic processing gives rise to the active protein.
messages: Required for growth and/or survival at acidic conditions.

349967:HRD69 RS09410
gene id: 349967:HRD69_RS09410
uniprot id: A0A7D4SW99
names: Function
names: Similarity
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.

349967:HRD69 RS15475
gene id: 349967:HRD69_RS15475
uniprot id: A0A7D4P3Q9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.
messages: Binds 3 [4Fe-4S] clusters.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

349967:HRD69 RS01510
gene id: 349967:HRD69_RS01510
uniprot id: A0A7D4P0J6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

349967:HRD69 RS00400
gene id: 349967:HRD69_RS00400
uniprot id: A0A7D4P8P0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

349967:HRD69 RS16905
gene id: 349967:HRD69_RS16905
uniprot id: A0A7D4U105
names: Function
names: Similarity
messages: Belongs to the arginine N-succinyltransferase family.
messages: Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine.

349967:HRD69 RS02285
gene id: 349967:HRD69_RS02285
uniprot id: A0A7D4U0C4
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS05175
gene id: 349967:HRD69_RS05175
uniprot id: A0A7D4P180
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.
messages: Catalyzes the sodium-dependent transport of glutamate.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS04785
gene id: 349967:HRD69_RS04785
uniprot id: A0A7D4PEF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RraA family.
messages: Cytoplasm
messages: Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome.
messages: Homotrimer. Binds to both RNA-binding sites in the C-terminal region of Rne and to RhlB.

349967:HRD69 RS10155
gene id: 349967:HRD69_RS10155
uniprot id: A0A7D4TR71
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.

349967:HRD69 RS08750
gene id: 349967:HRD69_RS08750
uniprot id: A0A7D4T1Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

349967:HRD69 RS07880
gene id: 349967:HRD69_RS07880
uniprot id: A0A7D4TMJ0
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS09145
gene id: 349967:HRD69_RS09145
uniprot id: A0A7D4P3H3
names: Similarity
messages: Belongs to the Nudix hydrolase family.

349967:HRD69 RS01620
gene id: 349967:HRD69_RS01620
uniprot id: A0A7D4P938
names: Similarity
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.
messages: Heterodimer of a large and a small subunit.

349967:HRD69 RS00255
gene id: 349967:HRD69_RS00255
uniprot id: A0A7D4TEG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

349967:HRD69 RS12735
gene id: 349967:HRD69_RS12735
uniprot id: A0A7D4T7A4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS09000
gene id: 349967:HRD69_RS09000
uniprot id: A0A7D4U2J6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

349967:HRD69 RS07340
gene id: 349967:HRD69_RS07340
uniprot id: A0A7D4U080
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS02950
gene id: 349967:HRD69_RS02950
uniprot id: A0A7D4T0W0
names: Function
names: Similarity
messages: Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1.B.42) family.
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system.

349967:HRD69 RS19045
gene id: 349967:HRD69_RS19045
uniprot id: A0A7D4PUA4
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.

349967:HRD69 RS04440
gene id: 349967:HRD69_RS04440
uniprot id: A0A7D4SVF1
names: Similarity
messages: Belongs to the colicins ColE2/ColE8/ColE9 and pyocins S1/S2 family.

349967:HRD69 RS13875
gene id: 349967:HRD69_RS13875
uniprot id: A0A7D4PCM9
names: Function
names: Similarity
messages: Belongs to the EfeM/EfeO family.
messages: Involved in Fe(2+) uptake. Could be an iron-binding and/or electron-transfer component.

349967:HRD69 RS12265
gene id: 349967:HRD69_RS12265
uniprot id: A0A7D4PG04
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS13810
gene id: 349967:HRD69_RS13810
uniprot id: A0A7D4SX04
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

349967:HRD69 RS02450
gene id: 349967:HRD69_RS02450
uniprot id: A0A7D4P993
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

349967:HRD69 RS15640
gene id: 349967:HRD69_RS15640
uniprot id: A0A7D4SXB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0060 family.
messages: Cell membrane

349967:HRD69 RS10795
gene id: 349967:HRD69_RS10795
uniprot id: A0A7D4PSG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

349967:HRD69 RS16445
gene id: 349967:HRD69_RS16445
uniprot id: A0A7D4U4E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.
messages: Cell membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

349967:HRD69 RS04670
gene id: 349967:HRD69_RS04670
uniprot id: A0A7D4P2I2
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

349967:HRD69 RS19620
gene id: 349967:HRD69_RS19620
uniprot id: A0A7D4PTW1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily.
messages: Binds 1 Mg(2+) ion per subunit. Ca(2+) may be able to substitute.
messages: Cytoplasm
messages: Probably phosphorylates lipids; the in vivo substrate is unknown.

349967:HRD69 RS03205
gene id: 349967:HRD69_RS03205
uniprot id: A0A7D4P0U3
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

349967:HRD69 RS04915
gene id: 349967:HRD69_RS04915
uniprot id: A0A7D4TLL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecB family.
messages: Cytoplasm
messages: Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer.
messages: One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.

349967:HRD69 RS15250
gene id: 349967:HRD69_RS15250
uniprot id: A0A7D4P3P6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Cob(I)alamin adenosyltransferase family.
messages: Cytoplasm
messages: Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids.

349967:HRD69 RS04085
gene id: 349967:HRD69_RS04085
uniprot id: A0A7D4PKK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

349967:HRD69 RS05720
gene id: 349967:HRD69_RS05720
uniprot id: A0A7D4P474
names: Cofactor
messages: Binds 1 Ca(2+) ion per subunit.

349967:HRD69 RS15885
gene id: 349967:HRD69_RS15885
uniprot id: A0A7D4TPJ6
names: Subcellular Location Annotation
messages: Cell inner membrane

349967:HRD69 RS06960
gene id: 349967:HRD69_RS06960
uniprot id: A0A7D4TY35
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

349967:HRD69 RS09950
gene id: 349967:HRD69_RS09950
uniprot id: A0A7D4P5I5
names: Similarity
messages: Belongs to the SorC transcriptional regulatory family.

349967:HRD69 RS02865
gene id: 349967:HRD69_RS02865
uniprot id: A0A7D4TIH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

349967:HRD69 RS11235
gene id: 349967:HRD69_RS11235
uniprot id: A0A7D4PSI4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

349967:HRD69 RS18080
gene id: 349967:HRD69_RS18080
uniprot id: A0A7D4T3P9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

349967:HRD69 RS17540
gene id: 349967:HRD69_RS17540
uniprot id: A0A7D4TM98
names: Similarity
messages: Belongs to the SIP oxidoreductase family.

349967:HRD69 RS13035
gene id: 349967:HRD69_RS13035
uniprot id: A0A7D4SWG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).

349967:HRD69 RS10470
gene id: 349967:HRD69_RS10470
uniprot id: A0A7D4PSA4
names: Function
names: Similarity
messages: Belongs to the AcpH family.
messages: Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP.

349967:HRD69 RS00815
gene id: 349967:HRD69_RS00815
uniprot id: A0A7D4TZT5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

349967:HRD69 RS18420
gene id: 349967:HRD69_RS18420
uniprot id: A0A7D4TMH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxT phosphotransferase family.
messages: Cell inner membrane
messages: Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1-diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P).

349967:HRD69 RS10310
gene id: 349967:HRD69_RS10310
uniprot id: A0A7D4TYW6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ApbE family.
messages: Cell inner membrane
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

349967:HRD69 RS19415
gene id: 349967:HRD69_RS19415
uniprot id: A0A7D4PHS8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

349967:HRD69 RS13880
gene id: 349967:HRD69_RS13880
uniprot id: A0A7D4P8W4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DyP-type peroxidase family. EfeB subfamily.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.
messages: Homodimer. Part of a ferrous iron transporter composed of EfeU, EfeO and EfeB.
messages: Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact.
messages: Periplasm

349967:HRD69 RS13740
gene id: 349967:HRD69_RS13740
uniprot id: A0A7D4TZX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell inner membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

349967:HRD69 RS15030
gene id: 349967:HRD69_RS15030
uniprot id: A0A7D4PBW8
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

349967:HRD69 RS00240
gene id: 349967:HRD69_RS00240
uniprot id: A0A7D4T0D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

349967:HRD69 RS18565
gene id: 349967:HRD69_RS18565
uniprot id: A0A7D4PE56
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

349967:HRD69 RS18755
gene id: 349967:HRD69_RS18755
uniprot id: A0A7D4TJ13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS04235
gene id: 349967:HRD69_RS04235
uniprot id: A0A7D4TX53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-1 family.
messages: Cytoplasm

349967:HRD69 RS07090
gene id: 349967:HRD69_RS07090
uniprot id: A0A7D4TY42
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.
messages: Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt. Acetylates CheY, the response regulator involved in flagellar movement and chemotaxis.

349967:HRD69 RS19065
gene id: 349967:HRD69_RS19065
uniprot id: A0A7D4SXT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

349967:HRD69 RS02610
gene id: 349967:HRD69_RS02610
uniprot id: A0A7D4T0T2
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS18360
gene id: 349967:HRD69_RS18360
uniprot id: A0A7D4P568
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.

349967:HRD69 RS19705
gene id: 349967:HRD69_RS19705
uniprot id: A0A7D4PAA0
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS03120
gene id: 349967:HRD69_RS03120
uniprot id: A0A7D4P3M8
names: Similarity
messages: Belongs to the UPF0307 family.

349967:HRD69 RS16900
gene id: 349967:HRD69_RS16900
uniprot id: A0A7D4TM35
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family. AstD subfamily.
messages: Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.

349967:HRD69 RS19330
gene id: 349967:HRD69_RS19330
uniprot id: A0A7D4T3X3
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NapC/NirT/NrfH family.
messages: Binds 4 heme groups per subunit.
messages: Membrane

349967:HRD69 RS18460
gene id: 349967:HRD69_RS18460
uniprot id: A0A7D4P7E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS14755
gene id: 349967:HRD69_RS14755
uniprot id: A0A7D4U1X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS05555
gene id: 349967:HRD69_RS05555
uniprot id: A0A7D4T1A5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

349967:HRD69 RS05470
gene id: 349967:HRD69_RS05470
uniprot id: A0A7D4TFH9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

349967:HRD69 RS11460
gene id: 349967:HRD69_RS11460
uniprot id: A0A7D4PI75
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SeqA family.
messages: Cytoplasm
messages: Homodimer. Polymerizes to form helical filaments.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.

349967:HRD69 RS13965
gene id: 349967:HRD69_RS13965
uniprot id: A0A7D4U1T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Cell inner membrane
messages: Membrane
messages: This protein catalyzes the committed step to the synthesis of the acidic phospholipids.

349967:HRD69 RS18275
gene id: 349967:HRD69_RS18275
uniprot id: A0A7D4PNN7
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

349967:HRD69 RS10565
gene id: 349967:HRD69_RS10565
uniprot id: A0A7D4P5N3
names: Similarity
messages: Belongs to the UPF0234 family.

349967:HRD69 RS18090
gene id: 349967:HRD69_RS18090
uniprot id: A0A7D4T8B3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

349967:HRD69 RS19905
gene id: 349967:HRD69_RS19905
uniprot id: A0A7D4PEH9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.

349967:HRD69 RS18355
gene id: 349967:HRD69_RS18355
uniprot id: A0A7D4P7E1
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS06610
gene id: 349967:HRD69_RS06610
uniprot id: A0A7D4TM64
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

349967:HRD69 RS03125
gene id: 349967:HRD69_RS03125
uniprot id: A0A7D4P284
names: Similarity
messages: Belongs to the barstar family.

349967:HRD69 RS15615
gene id: 349967:HRD69_RS15615
uniprot id: A0A7D4PSR7
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

349967:HRD69 RS09235
gene id: 349967:HRD69_RS09235
uniprot id: A0A7D4PBF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

349967:HRD69 RS05570
gene id: 349967:HRD69_RS05570
uniprot id: A0A7D4PPH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

349967:HRD69 RS02175
gene id: 349967:HRD69_RS02175
uniprot id: A0A7D4U0B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Cell inner membrane

349967:HRD69 RS13750
gene id: 349967:HRD69_RS13750
uniprot id: A0A7D4U1R2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Flagellar protein that affects chemotactic events.
messages: Membrane

349967:HRD69 RS17970
gene id: 349967:HRD69_RS17970
uniprot id: A0A7D4TQC3
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS16520
gene id: 349967:HRD69_RS16520
uniprot id: A0A7D4SX75
names: Similarity
messages: Belongs to the RutC family.

349967:HRD69 RS12950
gene id: 349967:HRD69_RS12950
uniprot id: A0A7D4THF1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

349967:HRD69 RS08855
gene id: 349967:HRD69_RS08855
uniprot id: A0A7D4SVL9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

349967:HRD69 RS08775
gene id: 349967:HRD69_RS08775
uniprot id: A0A7D4TYI7
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS12910
gene id: 349967:HRD69_RS12910
uniprot id: A0A7D4PSS2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS01770
gene id: 349967:HRD69_RS01770
uniprot id: A0A7D4PDH1
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS03435
gene id: 349967:HRD69_RS03435
uniprot id: A0A7D4P3P2
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

349967:HRD69 RS16140
gene id: 349967:HRD69_RS16140
uniprot id: A0A7D4P3V8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxine kinase family. PdxY subfamily.
messages: Homodimer.
messages: Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP.

349967:HRD69 RS09140
gene id: 349967:HRD69_RS09140
uniprot id: A0A7D4P5A7
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
messages: Repressed under conditions of excess protein secretion capacity and derepressed when protein secretion becomes limiting. This is regulated by SecM.

349967:HRD69 RS08370
gene id: 349967:HRD69_RS08370
uniprot id: A0A7D4PA21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family.
messages: Cytoplasm
messages: Homodecamer.
messages: Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5-phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA.

349967:HRD69 RS18105
gene id: 349967:HRD69_RS18105
uniprot id: A0A7D4U1H1
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

349967:HRD69 RS11075
gene id: 349967:HRD69_RS11075
uniprot id: A0A7D4PAW7
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS14245
gene id: 349967:HRD69_RS14245
uniprot id: A0A7D4PT08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HdeB family.
messages: Periplasm
messages: Required for optimal acid stress protection, which is important for survival of enteric bacteria in the acidic environment of the host stomach. Exhibits a chaperone-like activity at acidic pH by preventing the aggregation of many different periplasmic proteins.

349967:HRD69 RS05655
gene id: 349967:HRD69_RS05655
uniprot id: A0A7D4SUY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent.
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Monomer. Forms homomultimers of about 100-150 subunits at optimal growth temperatures. Conformation changes to monomers at high temperatures or high ionic concentrations.

349967:HRD69 RS15275
gene id: 349967:HRD69_RS15275
uniprot id: A0A7D4P4L2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS07400
gene id: 349967:HRD69_RS07400
uniprot id: A0A7D4PL91
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

349967:HRD69 RS08325
gene id: 349967:HRD69_RS08325
uniprot id: A0A7D4TMM8
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

349967:HRD69 RS13245
gene id: 349967:HRD69_RS13245
uniprot id: A0A7D4SWH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

349967:HRD69 RS16970
gene id: 349967:HRD69_RS16970
uniprot id: A0A7D4PH36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS08035
gene id: 349967:HRD69_RS08035
uniprot id: A0A7D4PB41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

349967:HRD69 RS06615
gene id: 349967:HRD69_RS06615
uniprot id: A0A7D4T619
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

349967:HRD69 RS11825
gene id: 349967:HRD69_RS11825
uniprot id: A0A7D4PRQ5
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS14960
gene id: 349967:HRD69_RS14960
uniprot id: A0A7D4TNS4
names: Cofactor
names: Similarity
messages: Belongs to the nitroreductase family.
messages: Binds 1 FMN per subunit.

349967:HRD69 RS11730
gene id: 349967:HRD69_RS11730
uniprot id: A0A7D4PFV7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS08830
gene id: 349967:HRD69_RS08830
uniprot id: A0A7D4PQK4
names: Function
names: Similarity
messages: Belongs to the ribF family.
messages: Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.

349967:HRD69 RS14885
gene id: 349967:HRD69_RS14885
uniprot id: A0A7D4P3M0
names: Similarity
messages: Belongs to the pirin family.

349967:HRD69 RS04725
gene id: 349967:HRD69_RS04725
uniprot id: A0A7D4TIZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

349967:HRD69 RS11855
gene id: 349967:HRD69_RS11855
uniprot id: A0A7D4T2M6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: In the C-terminal section; belongs to the complex I 49 kDa subunit family.
messages: In the N-terminal section; belongs to the complex I 30 kDa subunit family.
messages: NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

349967:HRD69 RS12730
gene id: 349967:HRD69_RS12730
uniprot id: A0A7D4TNQ5
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

349967:HRD69 RS06850
gene id: 349967:HRD69_RS06850
uniprot id: A0A7D4TFV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

349967:HRD69 RS00905
gene id: 349967:HRD69_RS00905
uniprot id: A0A7D4T4S0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

349967:HRD69 RS15285
gene id: 349967:HRD69_RS15285
uniprot id: A0A7D4PT81
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

349967:HRD69 RS07650
gene id: 349967:HRD69_RS07650
uniprot id: A0A7D4TMG9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation.
messages: May be beta-lysylated on the epsilon-amino group of Lys-34 by the combined action of EpmA and EpmB, and then hydroxylated on the C5 position of the same residue by EpmC (if this protein is present). Lysylation is critical for the stimulatory effect of EF-P on peptide-bond formation. The lysylation moiety may extend toward the peptidyltransferase center and stabilize the terminal 3-CCA end of the tRNA. Hydroxylation of the C5 position on Lys-34 may allow additional potential stabilizing hydrogen-bond interactions with the P-tRNA.

349967:HRD69 RS07515
gene id: 349967:HRD69_RS07515
uniprot id: A0A7D4SW02
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aromatic amine dehydrogenase light chain family.
messages: Heterotetramer of two light and two heavy chains.
messages: Periplasm

349967:HRD69 RS06135
gene id: 349967:HRD69_RS06135
uniprot id: A0A7D4PAC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

349967:HRD69 RS17930
gene id: 349967:HRD69_RS17930
uniprot id: A0A7D4P533
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoM family.
messages: Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs.

349967:HRD69 RS06945
gene id: 349967:HRD69_RS06945
uniprot id: A0A7D4T641
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

349967:HRD69 RS16955
gene id: 349967:HRD69_RS16955
uniprot id: A0A7D4P4W6
names: Similarity
messages: Belongs to the PhoH family.

349967:HRD69 RS17760
gene id: 349967:HRD69_RS17760
uniprot id: A0A7D4T3N1
names: Similarity
messages: Belongs to the UPF0319 family.

349967:HRD69 RS15520
gene id: 349967:HRD69_RS15520
uniprot id: A0A7D4PN01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 2 family.
messages: Periplasm

349967:HRD69 RS16390
gene id: 349967:HRD69_RS16390
uniprot id: A0A7D4PTG6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArnF family.
messages: Cell inner membrane
messages: Heterodimer of ArnE and ArnF.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane.

349967:HRD69 RS07770
gene id: 349967:HRD69_RS07770
uniprot id: A0A7D4TMI0
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

349967:HRD69 RS13080
gene id: 349967:HRD69_RS13080
uniprot id: A0A7D4SYE2
names: Subcellular Location Annotation
messages: Bacterial microcompartment

349967:HRD69 RS13170
gene id: 349967:HRD69_RS13170
uniprot id: A0A7D4TL72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

349967:HRD69 RS00820
gene id: 349967:HRD69_RS00820
uniprot id: A0A7D4TYH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

349967:HRD69 RS19140
gene id: 349967:HRD69_RS19140
uniprot id: A0A7D4U1Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CysZ family.
messages: Cell inner membrane
messages: High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway.

349967:HRD69 RS11590
gene id: 349967:HRD69_RS11590
uniprot id: A0A7D4T4C4
names: Function
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.
messages: E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

349967:HRD69 RS14355
gene id: 349967:HRD69_RS14355
uniprot id: A0A7D4PGF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

349967:HRD69 RS00790
gene id: 349967:HRD69_RS00790
uniprot id: A0A7D4T4R2
names: Similarity
messages: Belongs to the SdhE FAD assembly factor family.

349967:HRD69 RS05160
gene id: 349967:HRD69_RS05160
uniprot id: A0A7D4TXG1
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

349967:HRD69 RS04805
gene id: 349967:HRD69_RS04805
uniprot id: A0A7D4T166
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsN family.
messages: Cell inner membrane
messages: Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases.
messages: Interacts with FtsA via its N-terminal cytoplasmic domain.

349967:HRD69 RS04430
gene id: 349967:HRD69_RS04430
uniprot id: A0A7D4PED0
names: Subcellular Location Annotation
messages: Membrane
messages: Secreted
messages: host cytosol

349967:HRD69 RS13130
gene id: 349967:HRD69_RS13130
uniprot id: A0A7D4PG72
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial microcompartment
messages: Belongs to the bacterial microcompartments protein family.

349967:HRD69 RS18540
gene id: 349967:HRD69_RS18540
uniprot id: A0A7D4U1Q2
names: Subcellular Location Annotation
messages: Membrane
messages: Secreted
messages: host cytosol

349967:HRD69 RS10590
gene id: 349967:HRD69_RS10590
uniprot id: A0A7D4PLY4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane
messages: The cytochrome bo(3) ubiquinol oxidase complex is a heterooctamer of two A chains, two B chains, two C chains and two D chains.

349967:HRD69 RS12745
gene id: 349967:HRD69_RS12745
uniprot id: A0A7D4TKZ6
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.
messages: Toroid-shaped homodecamer, composed of two pentamers of five dimers.

349967:HRD69 RS10825
gene id: 349967:HRD69_RS10825
uniprot id: A0A7D4TN77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

349967:HRD69 RS17695
gene id: 349967:HRD69_RS17695
uniprot id: A0A7D4P470
names: Similarity
messages: Belongs to the ClpA/ClpB family.

349967:HRD69 RS01845
gene id: 349967:HRD69_RS01845
uniprot id: A0A7D4P956
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

349967:HRD69 RS07305
gene id: 349967:HRD69_RS07305
uniprot id: A0A7D4TME1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YscJ lipoprotein family.
messages: Cell outer membrane
messages: Membrane

349967:HRD69 RS10425
gene id: 349967:HRD69_RS10425
uniprot id: A0A7D4U2Z2
names: Function
messages: Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals.

349967:HRD69 RS02995
gene id: 349967:HRD69_RS02995
uniprot id: A0A7D4P8L8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

349967:HRD69 RS03680
gene id: 349967:HRD69_RS03680
uniprot id: A0A7D4P8S3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

349967:HRD69 RS08785
gene id: 349967:HRD69_RS08785
uniprot id: A0A7D4U2H9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

349967:HRD69 RS18060
gene id: 349967:HRD69_RS18060
uniprot id: A0A7D4PNM0
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

349967:HRD69 RS15160
gene id: 349967:HRD69_RS15160
uniprot id: A0A7D4P4K6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

349967:HRD69 RS18850
gene id: 349967:HRD69_RS18850
uniprot id: A0A7D4TQJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0312 family. Type 1 subfamily.
messages: Periplasm

349967:HRD69 RS05835
gene id: 349967:HRD69_RS05835
uniprot id: A0A7D4PR27
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

349967:HRD69 RS11935
gene id: 349967:HRD69_RS11935
uniprot id: A0A7D4PRR3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

349967:HRD69 RS06500
gene id: 349967:HRD69_RS06500
uniprot id: A0A7D4TM56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

349967:HRD69 RS04255
gene id: 349967:HRD69_RS04255
uniprot id: A0A7D4P8X1
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Involved in a late step of protoheme IX synthesis.
messages: Membrane

349967:HRD69 RS07425
gene id: 349967:HRD69_RS07425
uniprot id: A0A7D4TME9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

349967:HRD69 RS08060
gene id: 349967:HRD69_RS08060
uniprot id: A0A7D4PRN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

349967:HRD69 RS10915
gene id: 349967:HRD69_RS10915
uniprot id: A0A7D4SWI0
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

349967:HRD69 RS05010
gene id: 349967:HRD69_RS05010
uniprot id: A0A7D4T182
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

349967:HRD69 RS10290
gene id: 349967:HRD69_RS10290
uniprot id: A0A7D4TN45
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrC family.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

349967:HRD69 RS17360
gene id: 349967:HRD69_RS17360
uniprot id: A0A7D4PDK4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

349967:HRD69 RS02005
gene id: 349967:HRD69_RS02005
uniprot id: A0A7D4SV00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

349967:HRD69 RS18645
gene id: 349967:HRD69_RS18645
uniprot id: A0A7D4TMJ6
names: Similarity
messages: Belongs to the glycosyl hydrolase 24 family.

349967:HRD69 RS18345
gene id: 349967:HRD69_RS18345
uniprot id: A0A7D4PDX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Membrane

349967:HRD69 RS00385
gene id: 349967:HRD69_RS00385
uniprot id: A0A7D4TYF4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Homodimer.

349967:HRD69 RS07895
gene id: 349967:HRD69_RS07895
uniprot id: A0A7D4TJX3
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS17490
gene id: 349967:HRD69_RS17490
uniprot id: A0A7D4PTY4
names: Similarity
messages: Belongs to the autoinducer synthase family.

349967:HRD69 RS18715
gene id: 349967:HRD69_RS18715
uniprot id: A0A7D4PU82
names: Similarity
messages: Belongs to the UPF0381 family.

349967:HRD69 RS10840
gene id: 349967:HRD69_RS10840
uniprot id: A0A7D4TGV1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

349967:HRD69 RS17460
gene id: 349967:HRD69_RS17460
uniprot id: A0A7D4PCP2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. OpgH subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
messages: Membrane

349967:HRD69 RS02860
gene id: 349967:HRD69_RS02860
uniprot id: A0A7D4TF09
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

349967:HRD69 RS13660
gene id: 349967:HRD69_RS13660
uniprot id: A0A7D4PBH6
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

349967:HRD69 RS09070
gene id: 349967:HRD69_RS09070
uniprot id: A0A7D4SW85
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS07615
gene id: 349967:HRD69_RS07615
uniprot id: A0A7D4PQ93
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.

349967:HRD69 RS13415
gene id: 349967:HRD69_RS13415
uniprot id: A0A7D4P3A9
names: Subcellular Location Annotation
messages: Cytoplasm

349967:HRD69 RS15350
gene id: 349967:HRD69_RS15350
uniprot id: A0A7D4U455
names: Subcellular Location Annotation
messages: Cytoplasm

349967:HRD69 RS11815
gene id: 349967:HRD69_RS11815
uniprot id: A0A7D4P5X6
names: Similarity
messages: Belongs to the UPF0304 family.

349967:HRD69 RS00530
gene id: 349967:HRD69_RS00530
uniprot id: A0A7D4P1S6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetyltransferase family. ArgA subfamily.
messages: Cytoplasm
messages: Homohexamer.

349967:HRD69 RS09825
gene id: 349967:HRD69_RS09825
uniprot id: A0A7D4P2C0
names: Similarity
messages: Belongs to the heat shock protein 70 family.

349967:HRD69 RS19040
gene id: 349967:HRD69_RS19040
uniprot id: A0A7D4PTP4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS13680
gene id: 349967:HRD69_RS13680
uniprot id: A0A7D4P4C4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgH family.
messages: Cell outer membrane
messages: Membrane
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

349967:HRD69 RS11840
gene id: 349967:HRD69_RS11840
uniprot id: A0A7D4PM67
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS16545
gene id: 349967:HRD69_RS16545
uniprot id: A0A7D4TM01
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS14640
gene id: 349967:HRD69_RS14640
uniprot id: A0A7D4U1X1
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS16780
gene id: 349967:HRD69_RS16780
uniprot id: A0A7D4U0V9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

349967:HRD69 RS06870
gene id: 349967:HRD69_RS06870
uniprot id: A0A7D4U042
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

349967:HRD69 RS09615
gene id: 349967:HRD69_RS09615
uniprot id: A0A7D4PFI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsB family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

349967:HRD69 RS13840
gene id: 349967:HRD69_RS13840
uniprot id: A0A7D4THR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS09885
gene id: 349967:HRD69_RS09885
uniprot id: A0A7D4T276
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS11850
gene id: 349967:HRD69_RS11850
uniprot id: A0A7D4SW65
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

349967:HRD69 RS09110
gene id: 349967:HRD69_RS09110
uniprot id: A0A7D4U2K7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsQ/DivIB family. FtsQ subfamily.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

349967:HRD69 RS05615
gene id: 349967:HRD69_RS05615
uniprot id: A0A7D4P713
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

349967:HRD69 RS12255
gene id: 349967:HRD69_RS12255
uniprot id: A0A7D4PRU4
names: Function
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.
messages: Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.

349967:HRD69 RS08920
gene id: 349967:HRD69_RS08920
uniprot id: A0A7D4P580
names: Domain
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Homodimer.
messages: Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host.
messages: The transmembrane domain is a dimerization domain.

349967:HRD69 RS18165
gene id: 349967:HRD69_RS18165
uniprot id: A0A7D4PNN0
names: Function
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate.

349967:HRD69 RS03220
gene id: 349967:HRD69_RS03220
uniprot id: A0A7D4P6K9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

349967:HRD69 RS03330
gene id: 349967:HRD69_RS03330
uniprot id: A0A7D4P3N7
names: Similarity
messages: Belongs to the FGGY kinase family.

349967:HRD69 RS09165
gene id: 349967:HRD69_RS09165
uniprot id: A0A7D4PLN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

349967:HRD69 RS02220
gene id: 349967:HRD69_RS02220
uniprot id: A0A7D4PNJ6
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

349967:HRD69 RS00305
gene id: 349967:HRD69_RS00305
uniprot id: A0A7D4P325
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

349967:HRD69 RS20155
gene id: 349967:HRD69_RS20155
uniprot id: A0A7D4PHZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

349967:HRD69 RS09205
gene id: 349967:HRD69_RS09205
uniprot id: A0A7D4TYM4
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS10085
gene id: 349967:HRD69_RS10085
uniprot id: A0A7D4P3P5
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
messages: Cytoplasm

349967:HRD69 RS01005
gene id: 349967:HRD69_RS01005
uniprot id: A0A7D4T4S7
names: Similarity
messages: Belongs to the UPF0235 family.

349967:HRD69 RS20230
gene id: 349967:HRD69_RS20230
uniprot id: A0A7D4PAD1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS07020
gene id: 349967:HRD69_RS07020
uniprot id: A0A7D4PL72
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

349967:HRD69 RS10295
gene id: 349967:HRD69_RS10295
uniprot id: A0A7D4T6T2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

349967:HRD69 RS13185
gene id: 349967:HRD69_RS13185
uniprot id: A0A7D4U1M3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

349967:HRD69 RS02945
gene id: 349967:HRD69_RS02945
uniprot id: A0A7D4SUF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptA family.
messages: Component of the lipopolysaccharide transport and assembly complex.
messages: Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.
messages: Periplasm

349967:HRD69 RS03230
gene id: 349967:HRD69_RS03230
uniprot id: A0A7D4P291
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

349967:HRD69 RS16765
gene id: 349967:HRD69_RS16765
uniprot id: A0A7D4T816
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
messages: Homodimer.

349967:HRD69 RS06855
gene id: 349967:HRD69_RS06855
uniprot id: A0A7D4TJK6
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Methylated by PrmB.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

349967:HRD69 RS11895
gene id: 349967:HRD69_RS11895
uniprot id: A0A7D4U196
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS15040
gene id: 349967:HRD69_RS15040
uniprot id: A0A7D4P949
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

349967:HRD69 RS16935
gene id: 349967:HRD69_RS16935
uniprot id: A0A7D4PDF3
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS08900
gene id: 349967:HRD69_RS08900
uniprot id: A0A7D4P245
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

349967:HRD69 RS07410
gene id: 349967:HRD69_RS07410
uniprot id: A0A7D4SVZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

349967:HRD69 RS06535
gene id: 349967:HRD69_RS06535
uniprot id: A0A7D4P1J9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
messages: Monomer.

349967:HRD69 RS12875
gene id: 349967:HRD69_RS12875
uniprot id: A0A7D4P318
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0299 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

349967:HRD69 RS03475
gene id: 349967:HRD69_RS03475
uniprot id: A0A7D4SUJ1
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

349967:HRD69 RS03900
gene id: 349967:HRD69_RS03900
uniprot id: A0A7D4TF82
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

349967:HRD69 RS16360
gene id: 349967:HRD69_RS16360
uniprot id: A0A7D4PCF5
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

349967:HRD69 RS08955
gene id: 349967:HRD69_RS08955
uniprot id: A0A7D4SW81
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane
messages: The complex is composed of two ATP-binding proteins (ThiQ), two transmembrane proteins (ThiP) and a solute-binding protein (ThiB).

349967:HRD69 RS16920
gene id: 349967:HRD69_RS16920
uniprot id: A0A7D4P422
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS12845
gene id: 349967:HRD69_RS12845
uniprot id: A0A7D4T7B4
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

349967:HRD69 RS07785
gene id: 349967:HRD69_RS07785
uniprot id: A0A7D4TJW5
names: Cofactor
names: Function
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity.

349967:HRD69 RS07580
gene id: 349967:HRD69_RS07580
uniprot id: A0A7D4U098
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS16255
gene id: 349967:HRD69_RS16255
uniprot id: A0A7D4P9G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS13620
gene id: 349967:HRD69_RS13620
uniprot id: A0A7D4TP08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

349967:HRD69 RS17570
gene id: 349967:HRD69_RS17570
uniprot id: A0A7D4PDM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

349967:HRD69 RS09610
gene id: 349967:HRD69_RS09610
uniprot id: A0A7D4PS49
names: Similarity
messages: Belongs to the SorC transcriptional regulatory family.

349967:HRD69 RS04125
gene id: 349967:HRD69_RS04125
uniprot id: A0A7D4TX47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

349967:HRD69 RS10400
gene id: 349967:HRD69_RS10400
uniprot id: A0A7D4T6T8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RdgC family.
messages: May be involved in recombination.
messages: nucleoid

349967:HRD69 RS17420
gene id: 349967:HRD69_RS17420
uniprot id: A0A7D4T868
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

349967:HRD69 RS15125
gene id: 349967:HRD69_RS15125
uniprot id: A0A7D4U434
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TonB family.
messages: Cell inner membrane
messages: Homodimer. Forms a complex with the accessory proteins ExbB and ExbD.
messages: Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.

349967:HRD69 RS18750
gene id: 349967:HRD69_RS18750
uniprot id: A0A7D4T8G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbE subfamily.
messages: Cell inner membrane

349967:HRD69 RS01495
gene id: 349967:HRD69_RS01495
uniprot id: A0A7D4TWE2
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS07990
gene id: 349967:HRD69_RS07990
uniprot id: A0A7D4TG71
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

349967:HRD69 RS17170
gene id: 349967:HRD69_RS17170
uniprot id: A0A7D4PTV4
names: Subcellular Location Annotation
messages: Cell inner membrane

349967:HRD69 RS16465
gene id: 349967:HRD69_RS16465
uniprot id: A0A7D4PCG3
names: Similarity
messages: Belongs to the UPF0260 family.

349967:HRD69 RS00335
gene id: 349967:HRD69_RS00335
uniprot id: A0A7D4PJI9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

349967:HRD69 RS04285
gene id: 349967:HRD69_RS04285
uniprot id: A0A7D4P6S5
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 26 family.
messages: Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis.

349967:HRD69 RS17030
gene id: 349967:HRD69_RS17030
uniprot id: A0A7D4U2G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

349967:HRD69 RS19180
gene id: 349967:HRD69_RS19180
uniprot id: A0A7D4P5C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

349967:HRD69 RS16910
gene id: 349967:HRD69_RS16910
uniprot id: A0A7D4U4L5
names: Function
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. AstC subfamily.
messages: Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase.

349967:HRD69 RS08940
gene id: 349967:HRD69_RS08940
uniprot id: A0A7D4PRY8
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

349967:HRD69 RS10865
gene id: 349967:HRD69_RS10865
uniprot id: A0A7D4P2I6
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

349967:HRD69 RS15530
gene id: 349967:HRD69_RS15530
uniprot id: A0A7D4SX07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).

349967:HRD69 RS06725
gene id: 349967:HRD69_RS06725
uniprot id: A0A7D4U3G5
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

349967:HRD69 RS08515
gene id: 349967:HRD69_RS08515
uniprot id: A0A7D4PLI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 32 family.
messages: Cytoplasm
messages: Enables the bacterium to metabolize sucrose as a sole carbon source.

349967:HRD69 RS08385
gene id: 349967:HRD69_RS08385
uniprot id: A0A7D4P518
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).

349967:HRD69 RS13845
gene id: 349967:HRD69_RS13845
uniprot id: A0A7D4TLC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS10260
gene id: 349967:HRD69_RS10260
uniprot id: A0A7D4PS88
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

349967:HRD69 RS12695
gene id: 349967:HRD69_RS12695
uniprot id: A0A7D4PSQ9
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

349967:HRD69 RS11770
gene id: 349967:HRD69_RS11770
uniprot id: A0A7D4TKS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

349967:HRD69 RS18490
gene id: 349967:HRD69_RS18490
uniprot id: A0A7D4SXT3
names: Similarity
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane
messages: To H.influenzae HI_0842.

349967:HRD69 RS18765
gene id: 349967:HRD69_RS18765
uniprot id: A0A7D4U1R6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmD/CycX/HelD family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

349967:HRD69 RS13160
gene id: 349967:HRD69_RS13160
uniprot id: A0A7D4T7D4
names: Subcellular Location Annotation
messages: Bacterial microcompartment

349967:HRD69 RS09685
gene id: 349967:HRD69_RS09685
uniprot id: A0A7D4P2B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

349967:HRD69 RS18325
gene id: 349967:HRD69_RS18325
uniprot id: A0A7D4U2T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB-dependent receptor family.
messages: Cell outer membrane
messages: Membrane

349967:HRD69 RS09590
gene id: 349967:HRD69_RS09590
uniprot id: A0A7D4P814
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS04760
gene id: 349967:HRD69_RS04760
uniprot id: A0A7D4P6V5
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS09375
gene id: 349967:HRD69_RS09375
uniprot id: A0A7D4P3J2
names: Function
names: Similarity
messages: Belongs to the HPPK family.
messages: Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

349967:HRD69 RS00020
gene id: 349967:HRD69_RS00020
uniprot id: A0A7D4TZI7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

349967:HRD69 RS09530
gene id: 349967:HRD69_RS09530
uniprot id: A0A7D4T250
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Alpha(8)-beta(8). The alpha component is a flavoprotein, the beta component is a hemoprotein.
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Binds 1 siroheme per subunit.
messages: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.

349967:HRD69 RS07745
gene id: 349967:HRD69_RS07745
uniprot id: A0A7D4PF31
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

349967:HRD69 RS09215
gene id: 349967:HRD69_RS09215
uniprot id: A0A7D4U0N1
names: Function
messages: Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

349967:HRD69 RS07860
gene id: 349967:HRD69_RS07860
uniprot id: A0A7D4SW22
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

349967:HRD69 RS10055
gene id: 349967:HRD69_RS10055
uniprot id: A0A7D4P2D2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

349967:HRD69 RS13360
gene id: 349967:HRD69_RS13360
uniprot id: A0A7D4SWI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

349967:HRD69 RS13110
gene id: 349967:HRD69_RS13110
uniprot id: A0A7D4P695
names: Similarity
messages: Belongs to the CcmL/EutN family.

349967:HRD69 RS11315
gene id: 349967:HRD69_RS11315
uniprot id: A0A7D4P8F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS04980
gene id: 349967:HRD69_RS04980
uniprot id: A0A7D4PP98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

349967:HRD69 RS18475
gene id: 349967:HRD69_RS18475
uniprot id: A0A7D4PU66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

349967:HRD69 RS11465
gene id: 349967:HRD69_RS11465
uniprot id: A0A7D4P3X9
names: Similarity
messages: Belongs to the phosphohexose mutase family.

349967:HRD69 RS12645
gene id: 349967:HRD69_RS12645
uniprot id: A0A7D4U3J1
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

349967:HRD69 RS07885
gene id: 349967:HRD69_RS07885
uniprot id: A0A7D4T699
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

349967:HRD69 RS08710
gene id: 349967:HRD69_RS08710
uniprot id: A0A7D4P3D4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TrpR family.
messages: Cytoplasm
messages: Homodimer.
messages: This protein is an aporepressor. When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region.

349967:HRD69 RS05950
gene id: 349967:HRD69_RS05950
uniprot id: A0A7D4PKY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane.
messages: Part of the binding-protein-dependent transport system for D-xylose. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).

349967:HRD69 RS14745
gene id: 349967:HRD69_RS14745
uniprot id: A0A7D4U069
names: Similarity
messages: Belongs to the fructosamine kinase family.

349967:HRD69 RS11105
gene id: 349967:HRD69_RS11105
uniprot id: A0A7D4PRF1
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS08765
gene id: 349967:HRD69_RS08765
uniprot id: A0A7D4TGE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

349967:HRD69 RS01050
gene id: 349967:HRD69_RS01050
uniprot id: A0A7D4P8W1
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

349967:HRD69 RS07045
gene id: 349967:HRD69_RS07045
uniprot id: A0A7D4TMB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

349967:HRD69 RS02370
gene id: 349967:HRD69_RS02370
uniprot id: A0A7D4SU90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MzrA family.
messages: Cell inner membrane
messages: Interacts with EnvZ.
messages: Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR.

349967:HRD69 RS09925
gene id: 349967:HRD69_RS09925
uniprot id: A0A7D4P2C7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).

349967:HRD69 RS06955
gene id: 349967:HRD69_RS06955
uniprot id: A0A7D4TJL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

349967:HRD69 RS00340
gene id: 349967:HRD69_RS00340
uniprot id: A0A7D4SUP8
names: Function
names: Similarity
messages: Belongs to the LpxB family.
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

349967:HRD69 RS03730
gene id: 349967:HRD69_RS03730
uniprot id: A0A7D4SUL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NusG family.
messages: Monomer. Interacts with the transcription termination factor Rho and with RNA polymerase.
messages: Participates in transcription elongation, termination and antitermination. In the absence of Rho, increases the rate of transcription elongation by the RNA polymerase (RNAP), probably by partially suppressing pausing. In the presence of Rho, modulates most Rho-dependent termination events by interacting with the RNAP to render the complex more susceptible to the termination activity of Rho. May be required to overcome a kinetic limitation of Rho to function at certain terminators. Also involved in ribosomal RNA transcriptional antitermination.

349967:HRD69 RS11440
gene id: 349967:HRD69_RS11440
uniprot id: A0A7D4PAZ0
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

349967:HRD69 RS17140
gene id: 349967:HRD69_RS17140
uniprot id: A0A7D4PCL5
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

349967:HRD69 RS00945
gene id: 349967:HRD69_RS00945
uniprot id: A0A7D4P8V1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SprT family.
messages: Binds 1 zinc ion.
messages: Cytoplasm

349967:HRD69 RS12325
gene id: 349967:HRD69_RS12325
uniprot id: A0A7D4U1C9
names: Function
names: Similarity
messages: Belongs to the cycloisomerase 2 family.
messages: Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.

349967:HRD69 RS19980
gene id: 349967:HRD69_RS19980
uniprot id: A0A7D4P8D8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

349967:HRD69 RS04350
gene id: 349967:HRD69_RS04350
uniprot id: A0A7D4TIW7
names: Similarity
messages: Belongs to the thioredoxin family.

349967:HRD69 RS12620
gene id: 349967:HRD69_RS12620
uniprot id: A0A7D4TNP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS08365
gene id: 349967:HRD69_RS08365
uniprot id: A0A7D4P1Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LsrG family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the conversion of (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5-phosphonooxypentane-2,4-dione (P-HPD).

349967:HRD69 RS19580
gene id: 349967:HRD69_RS19580
uniprot id: A0A7D4U579
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily.
messages: Cell inner membrane
messages: Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtB forms a heteromultimer with MdtC.

349967:HRD69 RS10910
gene id: 349967:HRD69_RS10910
uniprot id: A0A7D4PM06
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS16530
gene id: 349967:HRD69_RS16530
uniprot id: A0A7D4TPQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtJ subfamily.
messages: Catalyzes the excretion of spermidine.
messages: Cell membrane
messages: Forms a complex with MdtI.
messages: Membrane

349967:HRD69 RS15045
gene id: 349967:HRD69_RS15045
uniprot id: A0A7D4P6Q1
names: Similarity
messages: In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
messages: In the N-terminal section; belongs to the aldehyde dehydrogenase family.

349967:HRD69 RS07955
gene id: 349967:HRD69_RS07955
uniprot id: A0A7D4PF45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

349967:HRD69 RS00810
gene id: 349967:HRD69_RS00810
uniprot id: A0A7D4TW46
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

349967:HRD69 RS10435
gene id: 349967:HRD69_RS10435
uniprot id: A0A7D4P2F3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched chain amino acid transporter family.
messages: Cell inner membrane
messages: Component of the transport system for branched-chain amino acids.
messages: Membrane

349967:HRD69 RS00210
gene id: 349967:HRD69_RS00210
uniprot id: A0A7D4SUP0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS16265
gene id: 349967:HRD69_RS16265
uniprot id: A0A7D4P4S5
names: Function
messages: Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.

349967:HRD69 RS00640
gene id: 349967:HRD69_RS00640
uniprot id: A0A7D4PN42
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS04580
gene id: 349967:HRD69_RS04580
uniprot id: A0A7D4TIY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).

349967:HRD69 RS15470
gene id: 349967:HRD69_RS15470
uniprot id: A0A7D4U232
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

349967:HRD69 RS03915
gene id: 349967:HRD69_RS03915
uniprot id: A0A7D4U0Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate.
messages: Cytoplasm

349967:HRD69 RS19870
gene id: 349967:HRD69_RS19870
uniprot id: A0A7D4TJA2
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

349967:HRD69 RS09800
gene id: 349967:HRD69_RS09800
uniprot id: A0A7D4TYS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS08625
gene id: 349967:HRD69_RS08625
uniprot id: A0A7D4PFA4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.
messages: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.

349967:HRD69 RS05530
gene id: 349967:HRD69_RS05530
uniprot id: A0A7D4PR07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS17805
gene id: 349967:HRD69_RS17805
uniprot id: A0A7D4PCS2
names: Similarity
messages: Belongs to the peptidase S16 family.

349967:HRD69 RS00580
gene id: 349967:HRD69_RS00580
uniprot id: A0A7D4T4P9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

349967:HRD69 RS01995
gene id: 349967:HRD69_RS01995
uniprot id: A0A7D4PDJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbA subfamily.
messages: Periplasm

349967:HRD69 RS04310
gene id: 349967:HRD69_RS04310
uniprot id: A0A7D4PEC2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WecD family.
messages: Catalyzes the acetylation of dTDP-fucosamine (dTDP-4-amino-4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS17280
gene id: 349967:HRD69_RS17280
uniprot id: A0A7D4PNF3
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS05495
gene id: 349967:HRD69_RS05495
uniprot id: A0A7D4P1A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS14910
gene id: 349967:HRD69_RS14910
uniprot id: A0A7D4P6P7
names: Similarity
messages: Belongs to the MipA/OmpV family.

349967:HRD69 RS15650
gene id: 349967:HRD69_RS15650
uniprot id: A0A7D4T388
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

349967:HRD69 RS12905
gene id: 349967:HRD69_RS12905
uniprot id: A0A7D4PS39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

349967:HRD69 RS11565
gene id: 349967:HRD69_RS11565
uniprot id: A0A7D4PBZ6
names: Similarity
messages: Belongs to the citrate synthase family.

349967:HRD69 RS13210
gene id: 349967:HRD69_RS13210
uniprot id: A0A7D4P6A2
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

349967:HRD69 RS13600
gene id: 349967:HRD69_RS13600
uniprot id: A0A7D4PMM6
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

349967:HRD69 RS15925
gene id: 349967:HRD69_RS15925
uniprot id: A0A7D4PCB7
names: Similarity
messages: Belongs to the Rpn/YhgA-like nuclease family.

349967:HRD69 RS12430
gene id: 349967:HRD69_RS12430
uniprot id: A0A7D4U1D5
names: Function
names: Similarity
messages: Belongs to the Dus family. DusC subfamily.
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs.

349967:HRD69 RS04835
gene id: 349967:HRD69_RS04835
uniprot id: A0A7D4U1D9
names: Similarity
names: Subunit
messages: Homotetramer.
messages: In the C-terminal section; belongs to the homoserine dehydrogenase family.
messages: In the N-terminal section; belongs to the aspartokinase family.

349967:HRD69 RS13745
gene id: 349967:HRD69_RS13745
uniprot id: A0A7D4U3S3
names: Function
names: Similarity
messages: Belongs to the FliK family.
messages: Controls the length of the flagellar hook.

349967:HRD69 RS04245
gene id: 349967:HRD69_RS04245
uniprot id: A0A7D4TZD7
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

349967:HRD69 RS06695
gene id: 349967:HRD69_RS06695
uniprot id: A0A7D4PR97
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in both the arginine and lysine biosynthetic pathways.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS11830
gene id: 349967:HRD69_RS11830
uniprot id: A0A7D4PSL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 5DNU family.
messages: Catalyzes the strictly specific dephosphorylation of 2'-deoxyribonucleoside 5'-monophosphates.
messages: Cytoplasm
messages: Homodimer.

349967:HRD69 RS09630
gene id: 349967:HRD69_RS09630
uniprot id: A0A7D4SVS4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

349967:HRD69 RS12835
gene id: 349967:HRD69_RS12835
uniprot id: A0A7D4TNR1
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS12995
gene id: 349967:HRD69_RS12995
uniprot id: A0A7D4P8P6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).

349967:HRD69 RS05235
gene id: 349967:HRD69_RS05235
uniprot id: A0A7D4T193
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

349967:HRD69 RS03860
gene id: 349967:HRD69_RS03860
uniprot id: A0A7D4PQL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 3'-5' exonuclease that prefers single-stranded DNA and RNA. May play a role in the H(2)O(2)-induced DNA damage repair.
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. TatD subfamily.
messages: Cytoplasm
messages: Monomer.

349967:HRD69 RS16285
gene id: 349967:HRD69_RS16285
uniprot id: A0A7D4PTE9
names: Similarity
messages: Belongs to the pyruvate kinase family.

349967:HRD69 RS18175
gene id: 349967:HRD69_RS18175
uniprot id: A0A7D4SXJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 3 family.
messages: Periplasm

349967:HRD69 RS06450
gene id: 349967:HRD69_RS06450
uniprot id: A0A7D4P761
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GlpE family.
messages: Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
messages: Cytoplasm

349967:HRD69 RS10615
gene id: 349967:HRD69_RS10615
uniprot id: A0A7D4T6U8
names: Similarity
messages: Belongs to the BolA/IbaG family.

349967:HRD69 RS17890
gene id: 349967:HRD69_RS17890
uniprot id: A0A7D4U1B3
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

349967:HRD69 RS06985
gene id: 349967:HRD69_RS06985
uniprot id: A0A7D4PAK9
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

349967:HRD69 RS05515
gene id: 349967:HRD69_RS05515
uniprot id: A0A7D4P458
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS17160
gene id: 349967:HRD69_RS17160
uniprot id: A0A7D4P4Y1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

349967:HRD69 RS13270
gene id: 349967:HRD69_RS13270
uniprot id: A0A7D4THI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

349967:HRD69 RS15950
gene id: 349967:HRD69_RS15950
uniprot id: A0A7D4PSU2
names: Function
names: Subunit
messages: Catalyzes the transfer of an acetyl group from acetyl-CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring.
messages: Homodimer.

349967:HRD69 RS03855
gene id: 349967:HRD69_RS03855
uniprot id: A0A7D4PNZ0
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

349967:HRD69 RS12250
gene id: 349967:HRD69_RS12250
uniprot id: A0A7D4P434
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

349967:HRD69 RS05180
gene id: 349967:HRD69_RS05180
uniprot id: A0A7D4P9B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

349967:HRD69 RS16235
gene id: 349967:HRD69_RS16235
uniprot id: A0A7D4U2A1
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

349967:HRD69 RS14605
gene id: 349967:HRD69_RS14605
uniprot id: A0A7D4T327
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS05275
gene id: 349967:HRD69_RS05275
uniprot id: A0A7D4P187
names: Function
names: Similarity
names: Subunit
messages: A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis.
messages: Belongs to the YihI family.
messages: Interacts with Der.

349967:HRD69 RS15595
gene id: 349967:HRD69_RS15595
uniprot id: A0A7D4PD28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tus family.
messages: Cytoplasm
messages: Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence.

349967:HRD69 RS09150
gene id: 349967:HRD69_RS09150
uniprot id: A0A7D4PQN8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA gyrase inhibitor YacG family.
messages: Binds 1 zinc ion.
messages: Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
messages: Interacts with GyrB.

349967:HRD69 RS11715
gene id: 349967:HRD69_RS11715
uniprot id: A0A7D4P3Z6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Homodimer.

349967:HRD69 RS16050
gene id: 349967:HRD69_RS16050
uniprot id: A0A7D4P9D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0283 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

349967:HRD69 RS19130
gene id: 349967:HRD69_RS19130
uniprot id: A0A7D4TJ43
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS04120
gene id: 349967:HRD69_RS04120
uniprot id: A0A7D4TIU6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.
messages: Membrane

349967:HRD69 RS19030
gene id: 349967:HRD69_RS19030
uniprot id: A0A7D4P7K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial glucokinase family.
messages: Cytoplasm

349967:HRD69 RS10430
gene id: 349967:HRD69_RS10430
uniprot id: A0A7D4U0Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PstS family.
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Periplasm
messages: Secreted

349967:HRD69 RS20470
gene id: 349967:HRD69_RS20470
uniprot id: A0A7D4P4U6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreD family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

349967:HRD69 RS14450
gene id: 349967:HRD69_RS14450
uniprot id: A0A7D4PSG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CopD family.
messages: Cell inner membrane
messages: Involved in copper resistance.
messages: Membrane

349967:HRD69 RS00110
gene id: 349967:HRD69_RS00110
uniprot id: A0A7D4THX1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
messages: Tetramer of two alpha and two beta subunits.

349967:HRD69 RS18570
gene id: 349967:HRD69_RS18570
uniprot id: A0A7D4P9X3
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS18875
gene id: 349967:HRD69_RS18875
uniprot id: A0A7D4U538
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MlaE permease family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute-binding proteins (MlaB) and six periplasmic solute-binding proteins (MlaD).

349967:HRD69 RS15495
gene id: 349967:HRD69_RS15495
uniprot id: A0A7D4P6T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3.A.1.109) family.
messages: Membrane

349967:HRD69 RS05875
gene id: 349967:HRD69_RS05875
uniprot id: A0A7D4TFL2
names: Similarity
messages: Belongs to the hyi family.

349967:HRD69 RS04985
gene id: 349967:HRD69_RS04985
uniprot id: A0A7D4PQW8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

349967:HRD69 RS16020
gene id: 349967:HRD69_RS16020
uniprot id: A0A7D4U0N5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M14 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in muropeptide degradation. Catalyzes the hydrolysis of the gamma-D-glutamyl-diaminopimelic acid (gamma-D-Glu-Dap) amide bond in the murein tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelic acid, leading to the formation of L-Ala-gamma-D-Glu and Dap.

349967:HRD69 RS06365
gene id: 349967:HRD69_RS06365
uniprot id: A0A7D4PPR2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS15720
gene id: 349967:HRD69_RS15720
uniprot id: A0A7D4P9A5
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

349967:HRD69 RS11695
gene id: 349967:HRD69_RS11695
uniprot id: A0A7D4PB05
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

349967:HRD69 RS09725
gene id: 349967:HRD69_RS09725
uniprot id: A0A7D4P3M2
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS03150
gene id: 349967:HRD69_RS03150
uniprot id: A0A7D4SV63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AaeX family.
messages: Cell membrane

349967:HRD69 RS06565
gene id: 349967:HRD69_RS06565
uniprot id: A0A7D4PPU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.
messages: Membrane

349967:HRD69 RS09045
gene id: 349967:HRD69_RS09045
uniprot id: A0A7D4P3G3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AlaE exporter family.
messages: Cell inner membrane
messages: Exports L-alanine.

349967:HRD69 RS17135
gene id: 349967:HRD69_RS17135
uniprot id: A0A7D4P435
names: Cofactor
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

349967:HRD69 RS19945
gene id: 349967:HRD69_RS19945
uniprot id: A0A7D4PP50
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Probably plays an important role in intracellular peptide degradation.

349967:HRD69 RS07755
gene id: 349967:HRD69_RS07755
uniprot id: A0A7D4SW15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

349967:HRD69 RS08590
gene id: 349967:HRD69_RS08590
uniprot id: A0A7D4PA41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

349967:HRD69 RS04825
gene id: 349967:HRD69_RS04825
uniprot id: A0A7D4TJ05
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MetJ family.
messages: Cytoplasm
messages: Does not bind DNA by a helix-turn-helix motif.
messages: Homodimer.
messages: This regulatory protein, when combined with SAM (S-adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis.

349967:HRD69 RS17105
gene id: 349967:HRD69_RS17105
uniprot id: A0A7D4T839
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS05430
gene id: 349967:HRD69_RS05430
uniprot id: A0A7D4PQZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

349967:HRD69 RS07595
gene id: 349967:HRD69_RS07595
uniprot id: A0A7D4PAR3
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

349967:HRD69 RS11960
gene id: 349967:HRD69_RS11960
uniprot id: A0A7D4SW70
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Catalyzes the dehydration of 6-phospho-D-gluconate to 2-dehydro-3-deoxy-6-phospho-D-gluconate.

349967:HRD69 RS16805
gene id: 349967:HRD69_RS16805
uniprot id: A0A7D4PDD6
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Member of a two-component regulatory system.

349967:HRD69 RS10325
gene id: 349967:HRD69_RS10325
uniprot id: A0A7D4P2E6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

349967:HRD69 RS10690
gene id: 349967:HRD69_RS10690
uniprot id: A0A7D4PLZ2
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS11405
gene id: 349967:HRD69_RS11405
uniprot id: A0A7D4T702
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

349967:HRD69 RS13715
gene id: 349967:HRD69_RS13715
uniprot id: A0A7D4T2X9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

349967:HRD69 RS11945
gene id: 349967:HRD69_RS11945
uniprot id: A0A7D4PFY0
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

349967:HRD69 RS00840
gene id: 349967:HRD69_RS00840
uniprot id: A0A7D4P652
names: Similarity
messages: Belongs to the UPF0149 family.

349967:HRD69 RS07750
gene id: 349967:HRD69_RS07750
uniprot id: A0A7D4PLB3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

349967:HRD69 RS04065
gene id: 349967:HRD69_RS04065
uniprot id: A0A7D4P2E0
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmD family.
messages: Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle.

349967:HRD69 RS12260
gene id: 349967:HRD69_RS12260
uniprot id: A0A7D4PSP1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedD family.
messages: Cell inner membrane
messages: Non-essential cell division protein that could be required for efficient cell constriction.
messages: The SPOR domain binds septal peptidoglycans and is required to target DedD to the septal ring.

349967:HRD69 RS09740
gene id: 349967:HRD69_RS09740
uniprot id: A0A7D4PS58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
messages: Cell outer membrane
messages: Membrane

349967:HRD69 RS04745
gene id: 349967:HRD69_RS04745
uniprot id: A0A7D4P151
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M20A family. ArgE subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the hydrolysis of the amide bond of N(2)-acetylated L-amino acids. Cleaves the acetyl group from N-acetyl-L-ornithine to form L-ornithine, an intermediate in L-arginine biosynthesis pathway, and a branchpoint in the synthesis of polyamines.
messages: Cytoplasm
messages: Homodimer.

349967:HRD69 RS10540
gene id: 349967:HRD69_RS10540
uniprot id: A0A7D4P2G2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

349967:HRD69 RS06140
gene id: 349967:HRD69_RS06140
uniprot id: A0A7D4P740
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

349967:HRD69 RS18395
gene id: 349967:HRD69_RS18395
uniprot id: A0A7D4SXN9
names: Similarity
messages: Belongs to the elongation factor P family.

349967:HRD69 RS02150
gene id: 349967:HRD69_RS02150
uniprot id: A0A7D4TKZ4
names: Similarity
messages: Belongs to the MotB family.

349967:HRD69 RS11420
gene id: 349967:HRD69_RS11420
uniprot id: A0A7D4TZ66
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

349967:HRD69 RS04210
gene id: 349967:HRD69_RS04210
uniprot id: A0A7D4TLG1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD, in which XerC interacts with XerD via its C-terminal region, XerD interacts with XerC via its C-terminal region and so on.
messages: FtsK may regulate the catalytic switch between XerC and XerD in the heterotetrameric complex during the two steps of the recombination process.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerD binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. In the complex XerC specifically exchanges the top DNA strands.

349967:HRD69 RS12920
gene id: 349967:HRD69_RS12920
uniprot id: A0A7D4PMG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuC/DcuD transporter (TC 2.A.61) family.
messages: Membrane

349967:HRD69 RS02825
gene id: 349967:HRD69_RS02825
uniprot id: A0A7D4PK92
names: PTM
names: Subcellular Location Annotation
messages: Activation requires a sequential transfer of a phosphate group from a His in the primary transmitter domain, to an Asp in the receiver domain and to a His in the secondary transmitter domain.
messages: Cell inner membrane

349967:HRD69 RS00590
gene id: 349967:HRD69_RS00590
uniprot id: A0A7D4TI05
names: Function
names: Similarity
messages: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
messages: Belongs to the Nudix hydrolase family. RppH subfamily.

349967:HRD69 RS10700
gene id: 349967:HRD69_RS10700
uniprot id: A0A7D4P4Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS05305
gene id: 349967:HRD69_RS05305
uniprot id: A0A7D4PPD5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Monomer.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

349967:HRD69 RS01670
gene id: 349967:HRD69_RS01670
uniprot id: A0A7D4SUX9
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

349967:HRD69 RS20415
gene id: 349967:HRD69_RS20415
uniprot id: A0A7D4SY64
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

349967:HRD69 RS09370
gene id: 349967:HRD69_RS09370
uniprot id: A0A7D4P5D2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

349967:HRD69 RS13460
gene id: 349967:HRD69_RS13460
uniprot id: A0A7D4PSW0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the P-Pant transferase superfamily. EntD family.
messages: EntB, EntD, EntE, and EntF form a multienzyme complex called enterobactin synthase.
messages: Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2+) atoms. Plays an essential role in the assembly of the enterobactin by catalyzing the transfer of the 4'-phosphopantetheine (Ppant) moiety from coenzyme A to the apo-domains of both EntB (ArCP domain) and EntF (PCP domain) to yield their holo-forms which make them competent for the activation of 2,3-dihydroxybenzoate (DHB) and L-serine, respectively.

349967:HRD69 RS15070
gene id: 349967:HRD69_RS15070
uniprot id: A0A7D4U3K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS01580
gene id: 349967:HRD69_RS01580
uniprot id: A0A7D4T4W4
names: Similarity
messages: Belongs to the HupF/HypC family.

349967:HRD69 RS07950
gene id: 349967:HRD69_RS07950
uniprot id: A0A7D4PRM7
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

349967:HRD69 RS01865
gene id: 349967:HRD69_RS01865
uniprot id: A0A7D4PNG7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS19320
gene id: 349967:HRD69_RS19320
uniprot id: A0A7D4SXY1
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

349967:HRD69 RS17100
gene id: 349967:HRD69_RS17100
uniprot id: A0A7D4TQ32
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

349967:HRD69 RS15305
gene id: 349967:HRD69_RS15305
uniprot id: A0A7D4SX92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LapB family.
messages: Cell inner membrane
messages: Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane.

349967:HRD69 RS13120
gene id: 349967:HRD69_RS13120
uniprot id: A0A7D4PS55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial microcompartment
messages: Belongs to the PduL family.
messages: Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate.

349967:HRD69 RS19025
gene id: 349967:HRD69_RS19025
uniprot id: A0A7D4PA48
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS00195
gene id: 349967:HRD69_RS00195
uniprot id: A0A7D4PPP4
names: Similarity
messages: Belongs to the transglycosylase Slt family.

349967:HRD69 RS16095
gene id: 349967:HRD69_RS16095
uniprot id: A0A7D4SX45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS12860
gene id: 349967:HRD69_RS12860
uniprot id: A0A7D4TZK3
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.
messages: Homotetramer.

349967:HRD69 RS12470
gene id: 349967:HRD69_RS12470
uniprot id: A0A7D4PSP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

349967:HRD69 RS14735
gene id: 349967:HRD69_RS14735
uniprot id: A0A7D4SYF3
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

349967:HRD69 RS00270
gene id: 349967:HRD69_RS00270
uniprot id: A0A7D4TZK6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

349967:HRD69 RS01010
gene id: 349967:HRD69_RS01010
uniprot id: A0A7D4TEM5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

349967:HRD69 RS16385
gene id: 349967:HRD69_RS16385
uniprot id: A0A7D4PSX9
names: Similarity
messages: Belongs to the peptidase C40 family.

349967:HRD69 RS15170
gene id: 349967:HRD69_RS15170
uniprot id: A0A7D4PT70
names: Function
names: Similarity
messages: Belongs to the TrpC family.
messages: Belongs to the TrpF family.
messages: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain.
messages: In the C-terminal section; belongs to the TrpF family.
messages: In the N-terminal section; belongs to the TrpC family.

349967:HRD69 RS19060
gene id: 349967:HRD69_RS19060
uniprot id: A0A7D4SXW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Cell membrane
messages: H(+)-stimulated, divalent metal cation uptake system.

349967:HRD69 RS16950
gene id: 349967:HRD69_RS16950
uniprot id: A0A7D4P732
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS09845
gene id: 349967:HRD69_RS09845
uniprot id: A0A7D4P5H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS17740
gene id: 349967:HRD69_RS17740
uniprot id: A0A7D4PH95
names: Similarity
messages: Belongs to the acylphosphatase family.

349967:HRD69 RS02985
gene id: 349967:HRD69_RS02985
uniprot id: A0A7D4TZ38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS19875
gene id: 349967:HRD69_RS19875
uniprot id: A0A7D4TNC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamB family.
messages: Cell outer membrane
messages: Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.

349967:HRD69 RS12380
gene id: 349967:HRD69_RS12380
uniprot id: A0A7D4PM95
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

349967:HRD69 RS06940
gene id: 349967:HRD69_RS06940
uniprot id: A0A7D4TMA0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

349967:HRD69 RS11035
gene id: 349967:HRD69_RS11035
uniprot id: A0A7D4TN90
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.

349967:HRD69 RS12635
gene id: 349967:HRD69_RS12635
uniprot id: A0A7D4TKY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. Tam family.
messages: Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.
messages: Cytoplasm

349967:HRD69 RS10550
gene id: 349967:HRD69_RS10550
uniprot id: A0A7D4PAS4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS16375
gene id: 349967:HRD69_RS16375
uniprot id: A0A7D4P701
names: Function
names: Similarity
messages: Belongs to the SELO family.
messages: Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).

349967:HRD69 RS03225
gene id: 349967:HRD69_RS03225
uniprot id: A0A7D4P3N2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Cell inner membrane
messages: Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins.
messages: Membrane

349967:HRD69 RS02380
gene id: 349967:HRD69_RS02380
uniprot id: A0A7D4TL14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ElaB/YgaM/YqjD family.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS13710
gene id: 349967:HRD69_RS13710
uniprot id: A0A7D4SWK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

349967:HRD69 RS08040
gene id: 349967:HRD69_RS08040
uniprot id: A0A7D4P7M2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

349967:HRD69 RS03715
gene id: 349967:HRD69_RS03715
uniprot id: A0A7D4PE52
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

349967:HRD69 RS03320
gene id: 349967:HRD69_RS03320
uniprot id: A0A7D4P9H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.
messages: Membrane

349967:HRD69 RS11045
gene id: 349967:HRD69_RS11045
uniprot id: A0A7D4TGX1
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

349967:HRD69 RS09345
gene id: 349967:HRD69_RS09345
uniprot id: A0A7D4U0P1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

349967:HRD69 RS08600
gene id: 349967:HRD69_RS08600
uniprot id: A0A7D4P7S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0391 family.
messages: Cell membrane

349967:HRD69 RS05455
gene id: 349967:HRD69_RS05455
uniprot id: A0A7D4T1A0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

349967:HRD69 RS17965
gene id: 349967:HRD69_RS17965
uniprot id: A0A7D4T3P4
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

349967:HRD69 RS00585
gene id: 349967:HRD69_RS00585
uniprot id: A0A7D4TEJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm

349967:HRD69 RS12075
gene id: 349967:HRD69_RS12075
uniprot id: A0A7D4SW77
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Autophosphorylated. Activation probably requires a transfer of a phosphate group from a His in the transmitter domain to an Asp in the receiver domain.
messages: Belongs to the RcsC family.
messages: Cell inner membrane
messages: Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane-associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB.
messages: Interacts with RcsD.

349967:HRD69 RS09785
gene id: 349967:HRD69_RS09785
uniprot id: A0A7D4TGM3
names: Function
names: Similarity
messages: Belongs to the class-C beta-lactamase family.
messages: This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.

349967:HRD69 RS10235
gene id: 349967:HRD69_RS10235
uniprot id: A0A7D4PBN3
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

349967:HRD69 RS10695
gene id: 349967:HRD69_RS10695
uniprot id: A0A7D4SWG9
names: Similarity
messages: Belongs to the P(II) protein family.

349967:HRD69 RS15550
gene id: 349967:HRD69_RS15550
uniprot id: A0A7D4T7T1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.

349967:HRD69 RS02930
gene id: 349967:HRD69_RS02930
uniprot id: A0A7D4PDV5
names: Similarity
names: Subunit
messages: Belongs to the SIS family. GutQ/KpsF subfamily.
messages: Homotetramer.

349967:HRD69 RS06950
gene id: 349967:HRD69_RS06950
uniprot id: A0A7D4TFW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

349967:HRD69 RS06735
gene id: 349967:HRD69_RS06735
uniprot id: A0A7D4T628
names: Similarity
messages: Belongs to the PhzF family.

349967:HRD69 RS07825
gene id: 349967:HRD69_RS07825
uniprot id: A0A7D4P7K2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PriB family.
messages: Binds single-stranded DNA at the primosome assembly site (PAS).
messages: Component of the preprimosomal complex composed of PriA, PriB, PriC, DnaB and DnaT. Upon transient interaction with DnaG it forms the primosome.

349967:HRD69 RS18480
gene id: 349967:HRD69_RS18480
uniprot id: A0A7D4PHK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YejK family.
messages: nucleoid

349967:HRD69 RS14100
gene id: 349967:HRD69_RS14100
uniprot id: A0A7D4PCP7
names: Similarity
messages: Belongs to the glycosyl hydrolase 24 family.

349967:HRD69 RS16145
gene id: 349967:HRD69_RS16145
uniprot id: A0A7D4PCD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

349967:HRD69 RS09065
gene id: 349967:HRD69_RS09065
uniprot id: A0A7D4PLM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transpeptidase family. FtsI subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.
messages: Cell inner membrane

349967:HRD69 RS01025
gene id: 349967:HRD69_RS01025
uniprot id: A0A7D4TZW0
names: Subcellular Location Annotation
messages: Membrane
messages: Secreted
messages: host cytosol

349967:HRD69 RS04040
gene id: 349967:HRD69_RS04040
uniprot id: A0A7D4P0Z6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PanZ/PanM family.
messages: Controls both the activation and catalytic activity of PanD in a coenzyme A (CoA)-dependent fashion.
messages: Interacts with PanD in the presence of CoA.

349967:HRD69 RS15750
gene id: 349967:HRD69_RS15750
uniprot id: A0A7D4PN22
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS16135
gene id: 349967:HRD69_RS16135
uniprot id: A0A7D4U292
names: Similarity
messages: Belongs to the GST superfamily.

349967:HRD69 RS05095
gene id: 349967:HRD69_RS05095
uniprot id: A0A7D4PPA9
names: Similarity
messages: Belongs to the OsmC/Ohr family.

349967:HRD69 RS11865
gene id: 349967:HRD69_RS11865
uniprot id: A0A7D4TNF7
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

349967:HRD69 RS13250
gene id: 349967:HRD69_RS13250
uniprot id: A0A7D4T2V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CbiQ family.
messages: Membrane

349967:HRD69 RS02155
gene id: 349967:HRD69_RS02155
uniprot id: A0A7D4T501
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

349967:HRD69 RS19490
gene id: 349967:HRD69_RS19490
uniprot id: A0A7D4PD73
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

349967:HRD69 RS14860
gene id: 349967:HRD69_RS14860
uniprot id: A0A7D4TI30
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS17945
gene id: 349967:HRD69_RS17945
uniprot id: A0A7D4PHD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
messages: Belongs to the KdsB family.
messages: Cytoplasm

349967:HRD69 RS09495
gene id: 349967:HRD69_RS09495
uniprot id: A0A7D4P3K5
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS19920
gene id: 349967:HRD69_RS19920
uniprot id: A0A7D4P5H4
names: Similarity
messages: In the C-terminal section; belongs to the transpeptidase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 51 family.

349967:HRD69 RS12290
gene id: 349967:HRD69_RS12290
uniprot id: A0A7D4TNK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane

349967:HRD69 RS11605
gene id: 349967:HRD69_RS11605
uniprot id: A0A7D4PM48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

349967:HRD69 RS16300
gene id: 349967:HRD69_RS16300
uniprot id: A0A7D4SXE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SufE family.
messages: Cytoplasm
messages: Homodimer. Interacts with SufS.
messages: Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process.

349967:HRD69 RS07970
gene id: 349967:HRD69_RS07970
uniprot id: A0A7D4SVD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

349967:HRD69 RS04905
gene id: 349967:HRD69_RS04905
uniprot id: A0A7D4SUT8
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

349967:HRD69 RS02805
gene id: 349967:HRD69_RS02805
uniprot id: A0A7D4P261
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SIS family. DiaA subfamily.
messages: Homotetramer; dimer of dimers.
messages: Required for the timely initiation of chromosomal replication via direct interactions with the DnaA initiator protein.

349967:HRD69 RS06875
gene id: 349967:HRD69_RS06875
uniprot id: A0A7D4P1M9
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

349967:HRD69 RS17090
gene id: 349967:HRD69_RS17090
uniprot id: A0A7D4SXB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:citrate (SCF) symporter family.
messages: Cell membrane

349967:HRD69 RS20350
gene id: 349967:HRD69_RS20350
uniprot id: A0A7D4PDF4
names: Similarity
messages: Belongs to the antirestriction protein family.

349967:HRD69 RS10485
gene id: 349967:HRD69_RS10485
uniprot id: A0A7D4PLY0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

349967:HRD69 RS11415
gene id: 349967:HRD69_RS11415
uniprot id: A0A7D4TKP7
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS18950
gene id: 349967:HRD69_RS18950
uniprot id: A0A7D4SXV8
names: Function
messages: Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds.

349967:HRD69 RS04945
gene id: 349967:HRD69_RS04945
uniprot id: A0A7D4TZM7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
messages: Cytoplasm
messages: Homotetramer.

349967:HRD69 RS17790
gene id: 349967:HRD69_RS17790
uniprot id: A0A7D4U4U7
names: Function
names: Induction
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the SulA family.
messages: By DNA damage, as part of the SOS response.
messages: Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division.
messages: Interacts with FtsZ.
messages: Is rapidly cleaved and degraded by the Lon protease once DNA damage is repaired.

349967:HRD69 RS03510
gene id: 349967:HRD69_RS03510
uniprot id: A0A7D4TWZ4
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the porin LamB (TC 1.B.3) family.
messages: By maltose.
messages: Cell outer membrane
messages: Homotrimer formed of three 18-stranded antiparallel beta-barrels, containing three independent channels.
messages: Involved in the transport of maltose and maltodextrins.
messages: Membrane

349967:HRD69 RS05130
gene id: 349967:HRD69_RS05130
uniprot id: A0A7D4T187
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

349967:HRD69 RS00825
gene id: 349967:HRD69_RS00825
uniprot id: A0A7D4P0E3
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

349967:HRD69 RS18735
gene id: 349967:HRD69_RS18735
uniprot id: A0A7D4SXQ9
names: Similarity
messages: Belongs to the MlaA family.

349967:HRD69 RS07855
gene id: 349967:HRD69_RS07855
uniprot id: A0A7D4PLC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RIC family. YtfE subfamily.
messages: Cytoplasm
messages: Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions.
messages: Homodimer.

349967:HRD69 RS12240
gene id: 349967:HRD69_RS12240
uniprot id: A0A7D4P8J9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS16490
gene id: 349967:HRD69_RS16490
uniprot id: A0A7D4PSY6
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

349967:HRD69 RS19440
gene id: 349967:HRD69_RS19440
uniprot id: A0A7D4TQP3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

349967:HRD69 RS04345
gene id: 349967:HRD69_RS04345
uniprot id: A0A7D4TFB0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.

349967:HRD69 RS16230
gene id: 349967:HRD69_RS16230
uniprot id: A0A7D4U4D2
names: Similarity
messages: Belongs to the peptidase C40 family.

349967:HRD69 RS03390
gene id: 349967:HRD69_RS03390
uniprot id: A0A7D4TF52
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS00175
gene id: 349967:HRD69_RS00175
uniprot id: A0A7D4PAE7
names: Function
names: Subunit
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease.
messages: The DNA polymerase holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential subassemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core (subunits alpha,epsilon and theta) contains the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork. This complex contains delta, delta', psi and chi, and copies of either or both of two different DnaX proteins, gamma and tau.

349967:HRD69 RS20115
gene id: 349967:HRD69_RS20115
uniprot id: A0A7D4P4R7
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS16340
gene id: 349967:HRD69_RS16340
uniprot id: A0A7D4U4E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

349967:HRD69 RS15120
gene id: 349967:HRD69_RS15120
uniprot id: A0A7D4U0A7
names: Similarity
messages: Belongs to the YciI family.

349967:HRD69 RS02820
gene id: 349967:HRD69_RS02820
uniprot id: A0A7D4PDU8
names: Function
names: Similarity
messages: Belongs to the peptidase C56 family.
messages: Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate.

349967:HRD69 RS05380
gene id: 349967:HRD69_RS05380
uniprot id: A0A7D4TXI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RavA family.
messages: Cytoplasm
messages: Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone.

349967:HRD69 RS05675
gene id: 349967:HRD69_RS05675
uniprot id: A0A7D4TFJ1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

349967:HRD69 RS16640
gene id: 349967:HRD69_RS16640
uniprot id: A0A7D4TPR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
messages: Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
messages: Homodimer.

349967:HRD69 RS19485
gene id: 349967:HRD69_RS19485
uniprot id: A0A7D4P4K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

349967:HRD69 RS06880
gene id: 349967:HRD69_RS06880
uniprot id: A0A7D4P9Q5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

349967:HRD69 RS01840
gene id: 349967:HRD69_RS01840
uniprot id: A0A7D4P870
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsP family.
messages: Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress.
messages: Periplasm

349967:HRD69 RS15460
gene id: 349967:HRD69_RS15460
uniprot id: A0A7D4U0E2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

349967:HRD69 RS16290
gene id: 349967:HRD69_RS16290
uniprot id: A0A7D4PGY6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A highly abundant outer membrane lipoprotein that controls the distance between the inner and outer membranes. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane.
messages: Belongs to the Lpp family.
messages: Cell outer membrane
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: cell wall

349967:HRD69 RS00005
gene id: 349967:HRD69_RS00005
uniprot id: A0A7D4PEN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreF family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

349967:HRD69 RS11705
gene id: 349967:HRD69_RS11705
uniprot id: A0A7D4P8H3
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS00895
gene id: 349967:HRD69_RS00895
uniprot id: A0A7D4T0H7
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

349967:HRD69 RS09880
gene id: 349967:HRD69_RS09880
uniprot id: A0A7D4SVU1
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS05485
gene id: 349967:HRD69_RS05485
uniprot id: A0A7D4U1K5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PstS family.
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

349967:HRD69 RS11230
gene id: 349967:HRD69_RS11230
uniprot id: A0A7D4PRI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TatA/E family. TatE subfamily.
messages: Cell inner membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA.

349967:HRD69 RS03560
gene id: 349967:HRD69_RS03560
uniprot id: A0A7D4PNW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AceK family.
messages: Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
messages: Cytoplasm

349967:HRD69 RS01980
gene id: 349967:HRD69_RS01980
uniprot id: A0A7D4PNG9
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

349967:HRD69 RS16650
gene id: 349967:HRD69_RS16650
uniprot id: A0A7D4TIH3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CutC family.
messages: Cytoplasm
messages: Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case.

349967:HRD69 RS14875
gene id: 349967:HRD69_RS14875
uniprot id: A0A7D4U417
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Belongs to the major facilitator superfamily. TCR/Tet family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter.

349967:HRD69 RS17370
gene id: 349967:HRD69_RS17370
uniprot id: A0A7D4P759
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YceF subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes 7-methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

349967:HRD69 RS11740
gene id: 349967:HRD69_RS11740
uniprot id: A0A7D4SWM5
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

349967:HRD69 RS03905
gene id: 349967:HRD69_RS03905
uniprot id: A0A7D4TIS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

349967:HRD69 RS08110
gene id: 349967:HRD69_RS08110
uniprot id: A0A7D4TJZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase U32 family. UbiU subfamily.
messages: Forms an heterodimer with UbiV.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiV, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway.

349967:HRD69 RS16450
gene id: 349967:HRD69_RS16450
uniprot id: A0A7D4U2N7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsbB family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein.

349967:HRD69 RS05090
gene id: 349967:HRD69_RS05090
uniprot id: A0A7D4P2K9
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS17735
gene id: 349967:HRD69_RS17735
uniprot id: A0A7D4PU07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dsrC/tusE family.
messages: Cytoplasm
messages: Interacts with the TusBCD complex. Interacts with MnmA.
messages: Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Could accept sulfur from TusD.

349967:HRD69 RS06195
gene id: 349967:HRD69_RS06195
uniprot id: A0A7D4TM21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RlmJ family.
messages: Monomer.
messages: Specifically methylates the adenine in position 2030 of 23S rRNA.

349967:HRD69 RS19795
gene id: 349967:HRD69_RS19795
uniprot id: A0A7D4P4P1
names: Similarity
messages: Belongs to the ClpA/ClpB family.

349967:HRD69 RS03290
gene id: 349967:HRD69_RS03290
uniprot id: A0A7D4TWX3
names: Function
names: Similarity
messages: Belongs to the Dus family. DusB subfamily.
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

349967:HRD69 RS15490
gene id: 349967:HRD69_RS15490
uniprot id: A0A7D4P986
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

349967:HRD69 RS20060
gene id: 349967:HRD69_RS20060
uniprot id: A0A7D4SY40
names: Similarity
messages: Belongs to the P(II) protein family.

349967:HRD69 RS19015
gene id: 349967:HRD69_RS19015
uniprot id: A0A7D4PD31
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS04060
gene id: 349967:HRD69_RS04060
uniprot id: A0A7D4P3S8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

349967:HRD69 RS19135
gene id: 349967:HRD69_RS19135
uniprot id: A0A7D4TMV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZipA family.
messages: Cell inner membrane
messages: Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins.
messages: Interacts with FtsZ via their C-terminal domains.

349967:HRD69 RS15625
gene id: 349967:HRD69_RS15625
uniprot id: A0A7D4PGU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.

349967:HRD69 RS04690
gene id: 349967:HRD69_RS04690
uniprot id: A0A7D4PKP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
messages: Cell inner membrane

349967:HRD69 RS02075
gene id: 349967:HRD69_RS02075
uniprot id: A0A7D4P974
names: Function
messages: Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.

349967:HRD69 RS00920
gene id: 349967:HRD69_RS00920
uniprot id: A0A7D4TW92
names: Function
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
messages: Catalyzes the biosynthesis of agmatine from arginine.

349967:HRD69 RS19970
gene id: 349967:HRD69_RS19970
uniprot id: A0A7D4T8R5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HesB/IscA family.
messages: Binds 2 iron ions per dimer. The dimer may bind additional iron ions.
messages: Homodimer; may form tetramers and higher multimers.
messages: Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB.

349967:HRD69 RS18530
gene id: 349967:HRD69_RS18530
uniprot id: A0A7D4TMI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

349967:HRD69 RS13900
gene id: 349967:HRD69_RS13900
uniprot id: A0A7D4PSZ1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NanM family.
messages: Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Periplasm

349967:HRD69 RS09395
gene id: 349967:HRD69_RS09395
uniprot id: A0A7D4PFG3
names: Similarity
messages: Belongs to the SfsA family.

349967:HRD69 RS15020
gene id: 349967:HRD69_RS15020
uniprot id: A0A7D4U5L7
names: Similarity
messages: Belongs to the UPF0225 family.

349967:HRD69 RS00855
gene id: 349967:HRD69_RS00855
uniprot id: A0A7D4P1T9
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

349967:HRD69 RS11585
gene id: 349967:HRD69_RS11585
uniprot id: A0A7D4PRN7
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

349967:HRD69 RS06590
gene id: 349967:HRD69_RS06590
uniprot id: A0A7D4TJH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial secretin family.
messages: Cell outer membrane
messages: Membrane

349967:HRD69 RS08480
gene id: 349967:HRD69_RS08480
uniprot id: A0A7D4PB81
names: Similarity
messages: Belongs to the NodU/CmcH family.

349967:HRD69 RS05590
gene id: 349967:HRD69_RS05590
uniprot id: A0A7D4U1L2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

349967:HRD69 RS12930
gene id: 349967:HRD69_RS12930
uniprot id: A0A7D4SWF4
names: Similarity
messages: Belongs to the UDPGP type 2 family.

349967:HRD69 RS07105
gene id: 349967:HRD69_RS07105
uniprot id: A0A7D4P1Q2
names: Subcellular Location Annotation
messages: Cell inner membrane

349967:HRD69 RS15600
gene id: 349967:HRD69_RS15600
uniprot id: A0A7D4P997
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS18025
gene id: 349967:HRD69_RS18025
uniprot id: A0A7D4PDV0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activation of pyruvate formate-lyase 1 under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm

349967:HRD69 RS09125
gene id: 349967:HRD69_RS09125
uniprot id: A0A7D4PAF8
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

349967:HRD69 RS17850
gene id: 349967:HRD69_RS17850
uniprot id: A0A7D4SXP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RlmKL family.
messages: Cytoplasm
messages: Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.

349967:HRD69 RS13440
gene id: 349967:HRD69_RS13440
uniprot id: A0A7D4TJL0
names: Subcellular Location Annotation
messages: Cytoplasm

349967:HRD69 RS04240
gene id: 349967:HRD69_RS04240
uniprot id: A0A7D4U119
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

349967:HRD69 RS04780
gene id: 349967:HRD69_RS04780
uniprot id: A0A7D4PQV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZapB family.
messages: Cytoplasm
messages: Homodimer. The ends of the coiled-coil dimer bind to each other, forming polymers. Interacts with FtsZ.
messages: Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA.

349967:HRD69 RS04920
gene id: 349967:HRD69_RS04920
uniprot id: A0A7D4T5P4
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

349967:HRD69 RS08005
gene id: 349967:HRD69_RS08005
uniprot id: A0A7D4U2A5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS04540
gene id: 349967:HRD69_RS04540
uniprot id: A0A7D4PEE0
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

349967:HRD69 RS04155
gene id: 349967:HRD69_RS04155
uniprot id: A0A7D4P6R7
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

349967:HRD69 RS09480
gene id: 349967:HRD69_RS09480
uniprot id: A0A7D4PBH8
names: Subcellular Location Annotation
messages: Cell inner membrane

349967:HRD69 RS09200
gene id: 349967:HRD69_RS09200
uniprot id: A0A7D4TK96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intimin/invasin family.
messages: Cell outer membrane
messages: Membrane

349967:HRD69 RS08240
gene id: 349967:HRD69_RS08240
uniprot id: A0A7D4P1X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS06460
gene id: 349967:HRD69_RS06460
uniprot id: A0A7D4P2V9
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Activated by ATP and maltotriose, which are both required for DNA binding.
messages: Belongs to the MalT family.
messages: Monomer in solution. Oligomerizes to an active state in the presence of the positive effectors ATP and maltotriose.
messages: Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box.

349967:HRD69 RS12375
gene id: 349967:HRD69_RS12375
uniprot id: A0A7D4PG14
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

349967:HRD69 RS13230
gene id: 349967:HRD69_RS13230
uniprot id: A0A7D4PG78
names: Function
names: Similarity
messages: Belongs to the CbiK family.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin.

349967:HRD69 RS11245
gene id: 349967:HRD69_RS11245
uniprot id: A0A7D4PM27
names: Similarity
messages: Belongs to the UPF0250 family.

349967:HRD69 RS08010
gene id: 349967:HRD69_RS08010
uniprot id: A0A7D4U0D6
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

349967:HRD69 RS15290
gene id: 349967:HRD69_RS15290
uniprot id: A0A7D4PAM2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: Homodimer.

349967:HRD69 RS08640
gene id: 349967:HRD69_RS08640
uniprot id: A0A7D4SVK0
names: Similarity
messages: Belongs to the HipA Ser/Thr kinase family.

349967:HRD69 RS12450
gene id: 349967:HRD69_RS12450
uniprot id: A0A7D4P8K8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinone-dependent D-lactate dehydrogenase family.
messages: Catalyzes the oxidation of D-lactate to pyruvate.
messages: Cell inner membrane

349967:HRD69 RS10045
gene id: 349967:HRD69_RS10045
uniprot id: A0A7D4U2W0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

349967:HRD69 RS07765
gene id: 349967:HRD69_RS07765
uniprot id: A0A7D4T1Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflK subfamily.
messages: HflC and HflK could encode or regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

349967:HRD69 RS12395
gene id: 349967:HRD69_RS12395
uniprot id: A0A7D4T2Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

349967:HRD69 RS11110
gene id: 349967:HRD69_RS11110
uniprot id: A0A7D4PSI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.

349967:HRD69 RS03520
gene id: 349967:HRD69_RS03520
uniprot id: A0A7D4TZ82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins.
messages: Part of the ABC transporter complex UgpBAEC involved in sn-glycerol-3-phosphate (G3P) import. Binds G3P.
messages: Periplasm
messages: The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).

349967:HRD69 RS20020
gene id: 349967:HRD69_RS20020
uniprot id: A0A7D4PEJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

349967:HRD69 RS09060
gene id: 349967:HRD69_RS09060
uniprot id: A0A7D4PFD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsL family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Membrane
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

349967:HRD69 RS00420
gene id: 349967:HRD69_RS00420
uniprot id: A0A7D4PN24
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family.
messages: Cytoplasm
messages: Homotrimer.

349967:HRD69 RS17270
gene id: 349967:HRD69_RS17270
uniprot id: A0A7D4PTW4
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

349967:HRD69 RS04460
gene id: 349967:HRD69_RS04460
uniprot id: A0A7D4T5L5
names: Similarity
messages: Belongs to the phage antitermination Q type 1 family.

349967:HRD69 RS19470
gene id: 349967:HRD69_RS19470
uniprot id: A0A7D4PE36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaA family. HdA subfamily.
messages: Mediates the interaction of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA.
messages: Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA.
messages: The active form seems to be an ADP-bound monomer. Forms the RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA, ADP-Hda and the DNA-loaded beta sliding clamp (dnaN).

349967:HRD69 RS12270
gene id: 349967:HRD69_RS12270
uniprot id: A0A7D4PM85
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS00740
gene id: 349967:HRD69_RS00740
uniprot id: A0A7D4P366
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

349967:HRD69 RS08990
gene id: 349967:HRD69_RS08990
uniprot id: A0A7D4TK73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Set transporter family.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS00330
gene id: 349967:HRD69_RS00330
uniprot id: A0A7D4P5L8
names: Subcellular Location Annotation
messages: Cytoplasm

349967:HRD69 RS02710
gene id: 349967:HRD69_RS02710
uniprot id: A0A7D4SV34
names: Similarity
messages: Belongs to the autoinducer synthase family.

349967:HRD69 RS03370
gene id: 349967:HRD69_RS03370
uniprot id: A0A7D4T0Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS19375
gene id: 349967:HRD69_RS19375
uniprot id: A0A7D4P4J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

349967:HRD69 RS13615
gene id: 349967:HRD69_RS13615
uniprot id: A0A7D4T2W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

349967:HRD69 RS01955
gene id: 349967:HRD69_RS01955
uniprot id: A0A7D4P884
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS01925
gene id: 349967:HRD69_RS01925
uniprot id: A0A7D4TWH6
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS00540
gene id: 349967:HRD69_RS00540
uniprot id: A0A7D4PPS0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.
messages: Belongs to the helicase family. UvrD subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding. Interacts with RecA.
messages: The C-terminal domain has nuclease activity and interacts with RecD. It interacts with RecA, facilitating its loading onto ssDNA.
messages: The N-terminal DNA-binding domain is a ssDNA-dependent ATPase and has ATP-dependent 3'-5' helicase function. This domain interacts with RecC.

349967:HRD69 RS02795
gene id: 349967:HRD69_RS02795
uniprot id: A0A7D4P6H4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LpoA family.
messages: Interacts with PBP1a.
messages: Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a).

349967:HRD69 RS11140
gene id: 349967:HRD69_RS11140
uniprot id: A0A7D4TN99
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS05250
gene id: 349967:HRD69_RS05250
uniprot id: A0A7D4TFG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

349967:HRD69 RS18040
gene id: 349967:HRD69_RS18040
uniprot id: A0A7D4P541
names: Function
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
messages: DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.

349967:HRD69 RS16725
gene id: 349967:HRD69_RS16725
uniprot id: A0A7D4PT04
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

349967:HRD69 RS16400
gene id: 349967:HRD69_RS16400
uniprot id: A0A7D4PN90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 83 family.
messages: Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

349967:HRD69 RS00450
gene id: 349967:HRD69_RS00450
uniprot id: A0A7D4T0F4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Syd family.
messages: Cell inner membrane
messages: Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function.

349967:HRD69 RS10585
gene id: 349967:HRD69_RS10585
uniprot id: A0A7D4PFN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
messages: Heterooctamer of two A chains, two B chains, two C chains and two D chains.
messages: Membrane

349967:HRD69 RS13165
gene id: 349967:HRD69_RS13165
uniprot id: A0A7D4THH2
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial microcompartment
messages: Belongs to the bacterial microcompartments protein family.

349967:HRD69 RS06910
gene id: 349967:HRD69_RS06910
uniprot id: A0A7D4PRC2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

349967:HRD69 RS09105
gene id: 349967:HRD69_RS09105
uniprot id: A0A7D4TYL3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

349967:HRD69 RS18370
gene id: 349967:HRD69_RS18370
uniprot id: A0A7D4PU59
names: Similarity
messages: Belongs to the Nudix hydrolase family.

349967:HRD69 RS08815
gene id: 349967:HRD69_RS08815
uniprot id: A0A7D4P569
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

349967:HRD69 RS07910
gene id: 349967:HRD69_RS07910
uniprot id: A0A7D4U0C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Cell inner membrane

349967:HRD69 RS05440
gene id: 349967:HRD69_RS05440
uniprot id: A0A7D4PKV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

349967:HRD69 RS09350
gene id: 349967:HRD69_RS09350
uniprot id: A0A7D4P286
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YtcA family.
messages: Membrane

349967:HRD69 RS18840
gene id: 349967:HRD69_RS18840
uniprot id: A0A7D4SXR6
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS07150
gene id: 349967:HRD69_RS07150
uniprot id: A0A7D4PEZ0
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

349967:HRD69 RS04750
gene id: 349967:HRD69_RS04750
uniprot id: A0A7D4P901
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 1 family.
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

349967:HRD69 RS17340
gene id: 349967:HRD69_RS17340
uniprot id: A0A7D4U4P8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

349967:HRD69 RS07890
gene id: 349967:HRD69_RS07890
uniprot id: A0A7D4TG59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TamA family.
messages: Cell outer membrane
messages: Membrane

349967:HRD69 RS00595
gene id: 349967:HRD69_RS00595
uniprot id: A0A7D4TW33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MutH family.
messages: Cytoplasm
messages: Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.

349967:HRD69 RS05790
gene id: 349967:HRD69_RS05790
uniprot id: A0A7D4U1N9
names: Similarity
messages: Belongs to the mannitol dehydrogenase family.

349967:HRD69 RS06485
gene id: 349967:HRD69_RS06485
uniprot id: A0A7D4SVT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Carboxylesterase BioH family.
messages: Cytoplasm
messages: Monomer.
messages: The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.

349967:HRD69 RS10515
gene id: 349967:HRD69_RS10515
uniprot id: A0A7D4TGS0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

349967:HRD69 RS02755
gene id: 349967:HRD69_RS02755
uniprot id: A0A7D4PDN0
names: Similarity
messages: Belongs to the GSP E family.

349967:HRD69 RS19865
gene id: 349967:HRD69_RS19865
uniprot id: A0A7D4T8Q7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS17025
gene id: 349967:HRD69_RS17025
uniprot id: A0A7D4U4M2
names: Similarity
messages: Belongs to the UPF0423 family.

349967:HRD69 RS00995
gene id: 349967:HRD69_RS00995
uniprot id: A0A7D4T0I8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

349967:HRD69 RS11995
gene id: 349967:HRD69_RS11995
uniprot id: A0A7D4TZC4
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS13355
gene id: 349967:HRD69_RS13355
uniprot id: A0A7D4SWX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial export usher family.
messages: Cell outer membrane
messages: Membrane

349967:HRD69 RS15050
gene id: 349967:HRD69_RS15050
uniprot id: A0A7D4P4K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS02885
gene id: 349967:HRD69_RS02885
uniprot id: A0A7D4P0S2
names: Similarity
messages: Belongs to the peptidase S1C family.

349967:HRD69 RS04950
gene id: 349967:HRD69_RS04950
uniprot id: A0A7D4P169
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
messages: Homodimer.

349967:HRD69 RS11660
gene id: 349967:HRD69_RS11660
uniprot id: A0A7D4U176
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Pal lipoprotein family.
messages: Cell outer membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

349967:HRD69 RS09160
gene id: 349967:HRD69_RS09160
uniprot id: A0A7D4PFE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

349967:HRD69 RS11640
gene id: 349967:HRD69_RS11640
uniprot id: A0A7D4TH20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbB/TolQ family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolR, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

349967:HRD69 RS00615
gene id: 349967:HRD69_RS00615
uniprot id: A0A7D4P7X7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: In the C-terminal section; belongs to the ATP-dependent AMP-binding enzyme family.
messages: In the N-terminal section; belongs to the 2-acyl-GPE acetyltransferase family.
messages: Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1.

349967:HRD69 RS16660
gene id: 349967:HRD69_RS16660
uniprot id: A0A7D4PDY9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

349967:HRD69 RS04415
gene id: 349967:HRD69_RS04415
uniprot id: A0A7D4PP47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial export usher family.
messages: Cell outer membrane
messages: Membrane

349967:HRD69 RS15370
gene id: 349967:HRD69_RS15370
uniprot id: A0A7D4PD09
names: Similarity
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

349967:HRD69 RS07725
gene id: 349967:HRD69_RS07725
uniprot id: A0A7D4P365
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueG family.
messages: Binds 2 [4Fe-4S] clusters per monomer.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

349967:HRD69 RS10595
gene id: 349967:HRD69_RS10595
uniprot id: A0A7D4SWG4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Cell membrane
messages: Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
messages: Heterooctamer of two A chains, two B chains, two C chains and two D chains.
messages: Membrane

349967:HRD69 RS00355
gene id: 349967:HRD69_RS00355
uniprot id: A0A7D4TKF9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-(hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

349967:HRD69 RS07000
gene id: 349967:HRD69_RS07000
uniprot id: A0A7D4P309
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell inner membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

349967:HRD69 RS03835
gene id: 349967:HRD69_RS03835
uniprot id: A0A7D4P6P6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
messages: Cytoplasm
messages: Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).

349967:HRD69 RS17865
gene id: 349967:HRD69_RS17865
uniprot id: A0A7D4TQA7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

349967:HRD69 RS01480
gene id: 349967:HRD69_RS01480
uniprot id: A0A7D4T4V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

349967:HRD69 RS19695
gene id: 349967:HRD69_RS19695
uniprot id: A0A7D4PD94
names: Function
names: Similarity
messages: Belongs to the GlgS family.
messages: Major determinant of cell surface composition. Negatively regulates motility, adhesion and synthesis of biofilm exopolysaccharides.

349967:HRD69 RS04470
gene id: 349967:HRD69_RS04470
uniprot id: A0A7D4TIX6
names: Function
names: Similarity
messages: Belongs to the colicin/pyosin nuclease family.
messages: Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria.

349967:HRD69 RS07865
gene id: 349967:HRD69_RS07865
uniprot id: A0A7D4P4X5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inositol monophosphatase superfamily. CysQ family.
messages: Cell inner membrane
messages: Converts adenosine-3',5'-bisphosphate (PAP) to AMP.

349967:HRD69 RS06635
gene id: 349967:HRD69_RS06635
uniprot id: A0A7D4U1W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

349967:HRD69 RS03155
gene id: 349967:HRD69_RS03155
uniprot id: A0A7D4SUH1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS18775
gene id: 349967:HRD69_RS18775
uniprot id: A0A7D4U2W3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

349967:HRD69 RS11950
gene id: 349967:HRD69_RS11950
uniprot id: A0A7D4PM73
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS18075
gene id: 349967:HRD69_RS18075
uniprot id: A0A7D4SXI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L/F-transferase family.
messages: Cytoplasm
messages: Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.

349967:HRD69 RS02915
gene id: 349967:HRD69_RS02915
uniprot id: A0A7D4P269
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MlaE permease family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute-binding proteins (MlaB) and six periplasmic solute-binding proteins (MlaD).

349967:HRD69 RS04660
gene id: 349967:HRD69_RS04660
uniprot id: A0A7D4P6U9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS01910
gene id: 349967:HRD69_RS01910
uniprot id: A0A7D4T4Y6
names: Similarity
messages: Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.

349967:HRD69 RS02090
gene id: 349967:HRD69_RS02090
uniprot id: A0A7D4P214
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CheZ family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P).

349967:HRD69 RS10835
gene id: 349967:HRD69_RS10835
uniprot id: A0A7D4PEV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Molecular chaperone. Has ATPase activity.

349967:HRD69 RS06420
gene id: 349967:HRD69_RS06420
uniprot id: A0A7D4TXW3
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

349967:HRD69 RS03645
gene id: 349967:HRD69_RS03645
uniprot id: A0A7D4TF68
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS19995
gene id: 349967:HRD69_RS19995
uniprot id: A0A7D4U5B3
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

349967:HRD69 RS18670
gene id: 349967:HRD69_RS18670
uniprot id: A0A7D4PCZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

349967:HRD69 RS03960
gene id: 349967:HRD69_RS03960
uniprot id: A0A7D4PP02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

349967:HRD69 RS09115
gene id: 349967:HRD69_RS09115
uniprot id: A0A7D4U0M1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

349967:HRD69 RS03865
gene id: 349967:HRD69_RS03865
uniprot id: A0A7D4PE64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

349967:HRD69 RS16005
gene id: 349967:HRD69_RS16005
uniprot id: A0A7D4TIC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Cell inner membrane
messages: Membrane
messages: Zinc transporter. Acts as a Zn(2+):proton symporter, which likely mediates zinc ion uptake.

349967:HRD69 RS15015
gene id: 349967:HRD69_RS15015
uniprot id: A0A7D4U1Z8
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

349967:HRD69 RS08280
gene id: 349967:HRD69_RS08280
uniprot id: A0A7D4PRU0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

349967:HRD69 RS06190
gene id: 349967:HRD69_RS06190
uniprot id: A0A7D4TR38
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

349967:HRD69 RS10945
gene id: 349967:HRD69_RS10945
uniprot id: A0A7D4TKL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS12025
gene id: 349967:HRD69_RS12025
uniprot id: A0A7D4PB31
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily.
messages: Cell inner membrane
messages: Involved in transporting aromatic amino acids across the cytoplasmic membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

349967:HRD69 RS13675
gene id: 349967:HRD69_RS13675
uniprot id: A0A7D4P6F0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

349967:HRD69 RS14385
gene id: 349967:HRD69_RS14385
uniprot id: A0A7D4T7K7
names: Similarity
messages: Belongs to the UPF0053 family.

349967:HRD69 RS02260
gene id: 349967:HRD69_RS02260
uniprot id: A0A7D4T509
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DoxX family.
messages: Membrane

349967:HRD69 RS10920
gene id: 349967:HRD69_RS10920
uniprot id: A0A7D4SW06
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

349967:HRD69 RS12900
gene id: 349967:HRD69_RS12900
uniprot id: A0A7D4P471
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

349967:HRD69 RS10975
gene id: 349967:HRD69_RS10975
uniprot id: A0A7D4PAV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GtrA family.
messages: Membrane

349967:HRD69 RS10670
gene id: 349967:HRD69_RS10670
uniprot id: A0A7D4P3S6
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. Cof family.
messages: Catalyzes the hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5-hydroxymethylpyrimidine phosphate (HMP-P).

349967:HRD69 RS10745
gene id: 349967:HRD69_RS10745
uniprot id: A0A7D4TZ10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS13305
gene id: 349967:HRD69_RS13305
uniprot id: A0A7D4PBE9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 2 subfamily.
messages: Cytoplasm
messages: Homotetramer.

349967:HRD69 RS11410
gene id: 349967:HRD69_RS11410
uniprot id: A0A7D4TGZ7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Allosterically activated by N-acetylglucosamine 6-phosphate (GlcNAc6P).
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS17895
gene id: 349967:HRD69_RS17895
uniprot id: A0A7D4U4V9
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS12480
gene id: 349967:HRD69_RS12480
uniprot id: A0A7D4PMA3
names: Similarity
messages: Belongs to the phosphate/phosphite/phosphonate binding protein family.

349967:HRD69 RS17080
gene id: 349967:HRD69_RS17080
uniprot id: A0A7D4PND6
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS12940
gene id: 349967:HRD69_RS12940
uniprot id: A0A7D4TNR7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

349967:HRD69 RS09035
gene id: 349967:HRD69_RS09035
uniprot id: A0A7D4P7V7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

349967:HRD69 RS14660
gene id: 349967:HRD69_RS14660
uniprot id: A0A7D4PCU6
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS06180
gene id: 349967:HRD69_RS06180
uniprot id: A0A7D4SV22
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS11780
gene id: 349967:HRD69_RS11780
uniprot id: A0A7D4U3B9
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS04815
gene id: 349967:HRD69_RS04815
uniprot id: A0A7D4T5N7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

349967:HRD69 RS05145
gene id: 349967:HRD69_RS05145
uniprot id: A0A7D4TFF3
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigB subfamily.
messages: Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.

349967:HRD69 RS05560
gene id: 349967:HRD69_RS05560
uniprot id: A0A7D4TLW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

349967:HRD69 RS03880
gene id: 349967:HRD69_RS03880
uniprot id: A0A7D4SUL9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC1 family. UbiB subfamily.
messages: Cell membrane
messages: Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS11330
gene id: 349967:HRD69_RS11330
uniprot id: A0A7D4PRL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS20465
gene id: 349967:HRD69_RS20465
uniprot id: A0A7D4U3A7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS03615
gene id: 349967:HRD69_RS03615
uniprot id: A0A7D4SV80
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

349967:HRD69 RS11980
gene id: 349967:HRD69_RS11980
uniprot id: A0A7D4TH50
names: Function
names: Similarity
messages: Belongs to the isochorismate synthase family.
messages: Catalyzes the conversion of chorismate to isochorismate.

349967:HRD69 RS16485
gene id: 349967:HRD69_RS16485
uniprot id: A0A7D4P4U0
names: Function
names: Similarity
names: Subunit
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.
messages: Interacts with MinC and FtsZ.

349967:HRD69 RS04640
gene id: 349967:HRD69_RS04640
uniprot id: A0A7D4P142
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. TrmA subfamily.
messages: Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).

349967:HRD69 RS09155
gene id: 349967:HRD69_RS09155
uniprot id: A0A7D4PRZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZapD family.
messages: Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
messages: Cytoplasm
messages: Interacts with FtsZ.

349967:HRD69 RS11520
gene id: 349967:HRD69_RS11520
uniprot id: A0A7D4TNC6
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Belongs to the DNA photolyase family.
messages: Binds 1 FAD per subunit.

349967:HRD69 RS00405
gene id: 349967:HRD69_RS00405
uniprot id: A0A7D4P623
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

349967:HRD69 RS20145
gene id: 349967:HRD69_RS20145
uniprot id: A0A7D4PU08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

349967:HRD69 RS18235
gene id: 349967:HRD69_RS18235
uniprot id: A0A7D4PDX0
names: Similarity
names: Subunit
messages: Belongs to the glutaredoxin family.
messages: Monomer.

349967:HRD69 RS09465
gene id: 349967:HRD69_RS09465
uniprot id: A0A7D4P298
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
messages: Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation.
messages: Homodimer.

349967:HRD69 RS03250
gene id: 349967:HRD69_RS03250
uniprot id: A0A7D4PKD2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MsrP family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.

349967:HRD69 RS05855
gene id: 349967:HRD69_RS05855
uniprot id: A0A7D4SV04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the formate dehydrogenase gamma subunit family.
messages: Membrane

349967:HRD69 RS05165
gene id: 349967:HRD69_RS05165
uniprot id: A0A7D4U1H4
names: Caution
names: Function
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS03315
gene id: 349967:HRD69_RS03315
uniprot id: A0A7D4P8P9
names: Subcellular Location Annotation
messages: Cytoplasm

349967:HRD69 RS17190
gene id: 349967:HRD69_RS17190
uniprot id: A0A7D4SXC1
names: Function
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family. NagK subfamily.
messages: Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.

349967:HRD69 RS08470
gene id: 349967:HRD69_RS08470
uniprot id: A0A7D4P1Z7
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.

349967:HRD69 RS17305
gene id: 349967:HRD69_RS17305
uniprot id: A0A7D4SXD1
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

349967:HRD69 RS11010
gene id: 349967:HRD69_RS11010
uniprot id: A0A7D4PFR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

349967:HRD69 RS05105
gene id: 349967:HRD69_RS05105
uniprot id: A0A7D4PEI0
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS20190
gene id: 349967:HRD69_RS20190
uniprot id: A0A7D4TJC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E.
messages: Belongs to the RseA family.
messages: Cell inner membrane
messages: Interacts 1:1 with ECF RNA polymerase sigma-E (RpoE); this inhibits the interaction of sigma-E with the RNA polymerase catalytic core and leads to a decreased expression of sigma-E-regulated genes. Interacts with RseB.

349967:HRD69 RS04955
gene id: 349967:HRD69_RS04955
uniprot id: A0A7D4P922
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.
messages: Binds 1 NADP(+) per subunit.
messages: Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
messages: Contains a large N-terminal NADP-binding domain, and a smaller C-terminal substrate-binding domain.
messages: Homopentamer.

349967:HRD69 RS02170
gene id: 349967:HRD69_RS02170
uniprot id: A0A7D4TWJ6
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

349967:HRD69 RS07960
gene id: 349967:HRD69_RS07960
uniprot id: A0A7D4PLC8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

349967:HRD69 RS16405
gene id: 349967:HRD69_RS16405
uniprot id: A0A7D4SXF1
names: Function
names: Similarity
messages: Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.
messages: Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.

349967:HRD69 RS15480
gene id: 349967:HRD69_RS15480
uniprot id: A0A7D4PC05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell inner membrane
messages: Membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

349967:HRD69 RS19345
gene id: 349967:HRD69_RS19345
uniprot id: A0A7D4U3N9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NapD family.
messages: Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin-arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export.
messages: Cytoplasm
messages: Interacts with the cytoplasmic NapA precursor.

349967:HRD69 RS03145
gene id: 349967:HRD69_RS03145
uniprot id: A0A7D4PKC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
messages: Cell membrane
messages: Forms an efflux pump with AaeB.

349967:HRD69 RS03395
gene id: 349967:HRD69_RS03395
uniprot id: A0A7D4TIN1
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS17200
gene id: 349967:HRD69_RS17200
uniprot id: A0A7D4TQ55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
messages: The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE).

349967:HRD69 RS10300
gene id: 349967:HRD69_RS10300
uniprot id: A0A7D4TGQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrDE/RnfAE family.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: Membrane
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

349967:HRD69 RS12115
gene id: 349967:HRD69_RS12115
uniprot id: A0A7D4U1B0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Gram-negative porin family.
messages: Cell outer membrane
messages: Homotrimer.
messages: Membrane

349967:HRD69 RS05690
gene id: 349967:HRD69_RS05690
uniprot id: A0A7D4U1M7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS09840
gene id: 349967:HRD69_RS09840
uniprot id: A0A7D4P835
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

349967:HRD69 RS06445
gene id: 349967:HRD69_RS06445
uniprot id: A0A7D4PAF3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Cell membrane
messages: Membrane
messages: Rhomboid-type serine protease that catalyzes intramembrane proteolysis.

349967:HRD69 RS05600
gene id: 349967:HRD69_RS05600
uniprot id: A0A7D4P1A7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

349967:HRD69 RS15455
gene id: 349967:HRD69_RS15455
uniprot id: A0A7D4TLP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RnfG family.
messages: Cell inner membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

349967:HRD69 RS10630
gene id: 349967:HRD69_RS10630
uniprot id: A0A7D4TZ00
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

349967:HRD69 RS19975
gene id: 349967:HRD69_RS19975
uniprot id: A0A7D4TJB0
names: Function
names: Similarity
messages: A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
messages: Belongs to the NifU family.

349967:HRD69 RS00410
gene id: 349967:HRD69_RS00410
uniprot id: A0A7D4P336
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

349967:HRD69 RS12040
gene id: 349967:HRD69_RS12040
uniprot id: A0A7D4P5Z5
names: Caution
names: Similarity
messages: Belongs to the peptidase S8 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS07975
gene id: 349967:HRD69_RS07975
uniprot id: A0A7D4T1R6
names: Subcellular Location Annotation
messages: Cell inner membrane

349967:HRD69 RS10350
gene id: 349967:HRD69_RS10350
uniprot id: A0A7D4P3Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

349967:HRD69 RS00495
gene id: 349967:HRD69_RS00495
uniprot id: A0A7D4P7X0
names: Similarity
messages: Belongs to the SufE family.

349967:HRD69 RS17515
gene id: 349967:HRD69_RS17515
uniprot id: A0A7D4T3M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS15980
gene id: 349967:HRD69_RS15980
uniprot id: A0A7D4SX38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS16590
gene id: 349967:HRD69_RS16590
uniprot id: A0A7D4P9I6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

349967:HRD69 RS02925
gene id: 349967:HRD69_RS02925
uniprot id: A0A7D4PQE0
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS01975
gene id: 349967:HRD69_RS01975
uniprot id: A0A7D4P203
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

349967:HRD69 RS19235
gene id: 349967:HRD69_RS19235
uniprot id: A0A7D4TMW6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

349967:HRD69 RS08420
gene id: 349967:HRD69_RS08420
uniprot id: A0A7D4SVG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arginine deiminase family.
messages: Cytoplasm

349967:HRD69 RS02060
gene id: 349967:HRD69_RS02060
uniprot id: A0A7D4TYS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Cell inner membrane
messages: FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

349967:HRD69 RS03815
gene id: 349967:HRD69_RS03815
uniprot id: A0A7D4TZ98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Cell inner membrane
messages: Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA.
messages: Membrane

349967:HRD69 RS06930
gene id: 349967:HRD69_RS06930
uniprot id: A0A7D4SV76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

349967:HRD69 RS00055
gene id: 349967:HRD69_RS00055
uniprot id: A0A7D4P1P7
names: Subcellular Location Annotation
messages: Cytoplasm

349967:HRD69 RS00040
gene id: 349967:HRD69_RS00040
uniprot id: A0A7D4P8K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

349967:HRD69 RS04200
gene id: 349967:HRD69_RS04200
uniprot id: A0A7D4SUP5
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

349967:HRD69 RS18265
gene id: 349967:HRD69_RS18265
uniprot id: A0A7D4PU52
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS09445
gene id: 349967:HRD69_RS09445
uniprot id: A0A7D4TYP6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HesB/IscA family.
messages: Binds 1 iron-sulfur cluster per subunit.
messages: Homodimer.
messages: Required for insertion of 4Fe-4S clusters for at least IspG.

349967:HRD69 RS07560
gene id: 349967:HRD69_RS07560
uniprot id: A0A7D4TG33
names: Function
names: Similarity
messages: Belongs to the HIBADH-related family. 2-hydroxy-3-oxopropionate reductase subfamily.
messages: Catalyzes the reduction of tatronate semialdehyde to D-glycerate.

349967:HRD69 RS03000
gene id: 349967:HRD69_RS03000
uniprot id: A0A7D4P9E4
names: Similarity
messages: Belongs to the RutC family.

349967:HRD69 RS03360
gene id: 349967:HRD69_RS03360
uniprot id: A0A7D4SV72
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

349967:HRD69 RS04170
gene id: 349967:HRD69_RS04170
uniprot id: A0A7D4P2F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

349967:HRD69 RS15715
gene id: 349967:HRD69_RS15715
uniprot id: A0A7D4PD38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane

349967:HRD69 RS04900
gene id: 349967:HRD69_RS04900
uniprot id: A0A7D4SVI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.

349967:HRD69 RS06805
gene id: 349967:HRD69_RS06805
uniprot id: A0A7D4PPW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DsrE/TusD family.
messages: Cytoplasm
messages: Heterohexamer, formed by a dimer of trimers. The hexameric TusBCD complex contains 2 copies each of TusB, TusC and TusD. The TusBCD complex interacts with TusE.
messages: Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE.

349967:HRD69 RS19610
gene id: 349967:HRD69_RS19610
uniprot id: A0A7D4P7R7
names: Similarity
messages: Belongs to the HipA Ser/Thr kinase family.

349967:HRD69 RS18920
gene id: 349967:HRD69_RS18920
uniprot id: A0A7D4PTN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPS (TC 1.B.20) family.
messages: Cell outer membrane
messages: Membrane

349967:HRD69 RS17075
gene id: 349967:HRD69_RS17075
uniprot id: A0A7D4PH43
names: Caution
names: Similarity
names: Subunit
messages: Belongs to the glutaminase family.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS03140
gene id: 349967:HRD69_RS03140
uniprot id: A0A7D4PDX4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family.
messages: Cell membrane
messages: Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS02590
gene id: 349967:HRD69_RS02590
uniprot id: A0A7D4PDP6
names: Similarity
messages: Belongs to the EcpB/EcpE family.

349967:HRD69 RS02025
gene id: 349967:HRD69_RS02025
uniprot id: A0A7D4TKY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliN/MopA/SpaO family.
messages: Cell membrane
messages: FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

349967:HRD69 RS05725
gene id: 349967:HRD69_RS05725
uniprot id: A0A7D4P2Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.
messages: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
messages: Cytoplasm
messages: Homodimer.

349967:HRD69 RS09220
gene id: 349967:HRD69_RS09220
uniprot id: A0A7D4P276
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 2 lipoyl cofactors covalently.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

349967:HRD69 RS08665
gene id: 349967:HRD69_RS08665
uniprot id: A0A7D4TK46
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

349967:HRD69 RS11115
gene id: 349967:HRD69_RS11115
uniprot id: A0A7D4PFR6
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

349967:HRD69 RS03500
gene id: 349967:HRD69_RS03500
uniprot id: A0A7D4TF61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiC family.
messages: Cytoplasm
messages: Monomer.
messages: Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.

349967:HRD69 RS03525
gene id: 349967:HRD69_RS03525
uniprot id: A0A7D4P0W9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (MalK), two transmembrane proteins (MalG and MalF) and a solute-binding protein (MalE).

349967:HRD69 RS11435
gene id: 349967:HRD69_RS11435
uniprot id: A0A7D4P2M7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

349967:HRD69 RS08495
gene id: 349967:HRD69_RS08495
uniprot id: A0A7D4P3B9
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS10535
gene id: 349967:HRD69_RS10535
uniprot id: A0A7D4U106
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

349967:HRD69 RS11485
gene id: 349967:HRD69_RS11485
uniprot id: A0A7D4SYC5
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS18310
gene id: 349967:HRD69_RS18310
uniprot id: A0A7D4TMG6
names: Similarity
messages: Belongs to the iron/ascorbate-dependent oxidoreductase family.

349967:HRD69 RS07915
gene id: 349967:HRD69_RS07915
uniprot id: A0A7D4P1V0
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS07660
gene id: 349967:HRD69_RS07660
uniprot id: A0A7D4TG43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Cell outer membrane
messages: Homodimer.
messages: Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids.

349967:HRD69 RS07730
gene id: 349967:HRD69_RS07730
uniprot id: A0A7D4PQA4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.

349967:HRD69 RS09580
gene id: 349967:HRD69_RS09580
uniprot id: A0A7D4PBI8
names: Similarity
messages: Belongs to the LacAB/RpiB family.

349967:HRD69 RS11490
gene id: 349967:HRD69_RS11490
uniprot id: A0A7D4PFU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpC family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

349967:HRD69 RS07795
gene id: 349967:HRD69_RS07795
uniprot id: A0A7D4U269
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the ribose of guanosine 2251 in 23S rRNA.

349967:HRD69 RS14635
gene id: 349967:HRD69_RS14635
uniprot id: A0A7D4U402
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS11240
gene id: 349967:HRD69_RS11240
uniprot id: A0A7D4PFS5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

349967:HRD69 RS09980
gene id: 349967:HRD69_RS09980
uniprot id: A0A7D4SWD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

349967:HRD69 RS03535
gene id: 349967:HRD69_RS03535
uniprot id: A0A7D4P9J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PsiE family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

349967:HRD69 RS16605
gene id: 349967:HRD69_RS16605
uniprot id: A0A7D4PSZ5
names: Cofactor
messages: Binds 1 Mg(2+) ion per subunit.

349967:HRD69 RS03420
gene id: 349967:HRD69_RS03420
uniprot id: A0A7D4P8Q5
names: Function
names: Subunit
messages: Homotetramer.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

349967:HRD69 RS08290
gene id: 349967:HRD69_RS08290
uniprot id: A0A7D4PLF2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptF/LptG family.
messages: Component of the lipopolysaccharide transport and assembly complex. The LptBFG transporter is composed of two ATP-binding proteins (LptB) and two transmembrane proteins (LptF and LptG).
messages: Membrane
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane.

349967:HRD69 RS01880
gene id: 349967:HRD69_RS01880
uniprot id: A0A7D4PJZ7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase class-III family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.

349967:HRD69 RS02345
gene id: 349967:HRD69_RS02345
uniprot id: A0A7D4PQ89
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

349967:HRD69 RS15565
gene id: 349967:HRD69_RS15565
uniprot id: A0A7D4TLQ0
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS09560
gene id: 349967:HRD69_RS09560
uniprot id: A0A7D4U2R2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PAPS reductase family. CysD subfamily.
messages: Heterodimer composed of CysD, the smaller subunit, and CysN.
messages: With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

349967:HRD69 RS12615
gene id: 349967:HRD69_RS12615
uniprot id: A0A7D4T2R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS16915
gene id: 349967:HRD69_RS16915
uniprot id: A0A7D4U2F8
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

349967:HRD69 RS18335
gene id: 349967:HRD69_RS18335
uniprot id: A0A7D4PCW8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS00360
gene id: 349967:HRD69_RS00360
uniprot id: A0A7D4T4N6
names: Similarity
messages: Belongs to the skp family.

349967:HRD69 RS19430
gene id: 349967:HRD69_RS19430
uniprot id: A0A7D4SXV6
names: Similarity
messages: Belongs to the SAICAR synthetase family.

349967:HRD69 RS09485
gene id: 349967:HRD69_RS09485
uniprot id: A0A7D4P802
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

349967:HRD69 RS16730
gene id: 349967:HRD69_RS16730
uniprot id: A0A7D4PTJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

349967:HRD69 RS15145
gene id: 349967:HRD69_RS15145
uniprot id: A0A7D4PCY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0259 family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

349967:HRD69 RS16420
gene id: 349967:HRD69_RS16420
uniprot id: A0A7D4TPP6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily.
messages: Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
messages: Homodimer.

349967:HRD69 RS15620
gene id: 349967:HRD69_RS15620
uniprot id: A0A7D4PTA4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS10815
gene id: 349967:HRD69_RS10815
uniprot id: A0A7D4SVZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

349967:HRD69 RS11545
gene id: 349967:HRD69_RS11545
uniprot id: A0A7D4U394
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LamB/PxpA family.
messages: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Forms a complex composed of PxpA, PxpB and PxpC.

349967:HRD69 RS14830
gene id: 349967:HRD69_RS14830
uniprot id: A0A7D4SX64
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

349967:HRD69 RS02720
gene id: 349967:HRD69_RS02720
uniprot id: A0A7D4T0T9
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS00080
gene id: 349967:HRD69_RS00080
uniprot id: A0A7D4SUN0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ElaB/YgaM/YqjD family.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS03115
gene id: 349967:HRD69_RS03115
uniprot id: A0A7D4P6J9
names: Similarity
messages: Belongs to the peptidase U62 family.

349967:HRD69 RS06885
gene id: 349967:HRD69_RS06885
uniprot id: A0A7D4PAJ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

349967:HRD69 RS16685
gene id: 349967:HRD69_RS16685
uniprot id: A0A7D4P401
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. DHA1 family. MdtH (TC 2.A.1.2.21) subfamily.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS16895
gene id: 349967:HRD69_RS16895
uniprot id: A0A7D4TIJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinylarginine dihydrolase family.
messages: Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2).
messages: Homodimer.

349967:HRD69 RS12790
gene id: 349967:HRD69_RS12790
uniprot id: A0A7D4P466
names: Similarity
messages: Belongs to the peptidase A31 family.

349967:HRD69 RS08125
gene id: 349967:HRD69_RS08125
uniprot id: A0A7D4PET6
names: Similarity
messages: Belongs to the UPF0213 family.

349967:HRD69 RS14970
gene id: 349967:HRD69_RS14970
uniprot id: A0A7D4U2M5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Binds two Mg(2+) per subunit.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

349967:HRD69 RS03355
gene id: 349967:HRD69_RS03355
uniprot id: A0A7D4PKE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxL/LpxM/LpxP family. LpxP subfamily.
messages: Catalyzes the transfer of an acyl chain from an acyl-[acyl-carrier-protein] (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(acyl)-lipid IV(A).
messages: Cell inner membrane

349967:HRD69 RS10390
gene id: 349967:HRD69_RS10390
uniprot id: A0A7D4T2A2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family. AroL subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.
messages: The LID domain closes over the active site upon ATP binding.

349967:HRD69 RS05730
gene id: 349967:HRD69_RS05730
uniprot id: A0A7D4PPI8
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS10340
gene id: 349967:HRD69_RS10340
uniprot id: A0A7D4P875
names: Function
names: Similarity
messages: Belongs to the FrsA family.
messages: Catalyzes the hydrolysis of esters.

349967:HRD69 RS17505
gene id: 349967:HRD69_RS17505
uniprot id: A0A7D4SXM5
names: Function
names: Similarity
messages: Belongs to the CcmH/CycL/Ccl2/NrfF family.
messages: Possible subunit of a heme lyase.

349967:HRD69 RS14430
gene id: 349967:HRD69_RS14430
uniprot id: A0A7D4PCS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Cytoplasm

349967:HRD69 RS15920
gene id: 349967:HRD69_RS15920
uniprot id: A0A7D4P3U0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

349967:HRD69 RS02165
gene id: 349967:HRD69_RS02165
uniprot id: A0A7D4TIC8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FlhD family.
messages: Cytoplasm
messages: Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.
messages: Homodimer; disulfide-linked. Forms a heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers.
messages: The C-terminal region contains a putative helix-turn-helix (HTH) motif, suggesting that this region may bind DNA.

349967:HRD69 RS08905
gene id: 349967:HRD69_RS08905
uniprot id: A0A7D4PAA3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PdxA family.
messages: Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+).
messages: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
messages: Cytoplasm
messages: Homodimer.
messages: The active site is located at the dimer interface.

349967:HRD69 RS04930
gene id: 349967:HRD69_RS04930
uniprot id: A0A7D4TJ14
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

349967:HRD69 RS10780
gene id: 349967:HRD69_RS10780
uniprot id: A0A7D4P5Q4
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

349967:HRD69 RS00470
gene id: 349967:HRD69_RS00470
uniprot id: A0A7D4THZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
messages: Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
messages: Cytoplasm
messages: Monomer.

349967:HRD69 RS08015
gene id: 349967:HRD69_RS08015
uniprot id: A0A7D4P1V7
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

349967:HRD69 RS04890
gene id: 349967:HRD69_RS04890
uniprot id: A0A7D4PEG3
names: Subcellular Location Annotation
messages: Cell inner membrane

349967:HRD69 RS01485
gene id: 349967:HRD69_RS01485
uniprot id: A0A7D4TEQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

349967:HRD69 RS12630
gene id: 349967:HRD69_RS12630
uniprot id: A0A7D4THC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Dps family.
messages: Cytoplasm
messages: During stationary phase, binds the chromosome non-specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction.
messages: Homododecamer. The 12 subunits form a hollow sphere into which the mineral iron core of up to 500 Fe(3+) can be deposited.

349967:HRD69 RS11090
gene id: 349967:HRD69_RS11090
uniprot id: A0A7D4P5S6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

349967:HRD69 RS04485
gene id: 349967:HRD69_RS04485
uniprot id: A0A7D4TZJ1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS17985
gene id: 349967:HRD69_RS17985
uniprot id: A0A7D4TIU5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS1 family.
messages: Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.

349967:HRD69 RS12120
gene id: 349967:HRD69_RS12120
uniprot id: A0A7D4P2V4
names: Similarity
messages: Belongs to the UPF0115 family.

349967:HRD69 RS06395
gene id: 349967:HRD69_RS06395
uniprot id: A0A7D4T1F7
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS14260
gene id: 349967:HRD69_RS14260
uniprot id: A0A7D4SX32
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS18210
gene id: 349967:HRD69_RS18210
uniprot id: A0A7D4U1I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

349967:HRD69 RS11765
gene id: 349967:HRD69_RS11765
uniprot id: A0A7D4TH27
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

349967:HRD69 RS12295
gene id: 349967:HRD69_RS12295
uniprot id: A0A7D4U3J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS19590
gene id: 349967:HRD69_RS19590
uniprot id: A0A7D4P4L8
names: Subcellular Location Annotation
messages: Cell inner membrane

349967:HRD69 RS03410
gene id: 349967:HRD69_RS03410
uniprot id: A0A7D4TZ73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

349967:HRD69 RS02605
gene id: 349967:HRD69_RS02605
uniprot id: A0A7D4SUA1
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

349967:HRD69 RS00990
gene id: 349967:HRD69_RS00990
uniprot id: A0A7D4SU23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Monomer.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

349967:HRD69 RS02180
gene id: 349967:HRD69_RS02180
uniprot id: A0A7D4TYT7
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Secreted

349967:HRD69 RS04395
gene id: 349967:HRD69_RS04395
uniprot id: A0A7D4P9S8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. UvrD subfamily.
messages: Homodimer.
messages: Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction.

349967:HRD69 RS08525
gene id: 349967:HRD69_RS08525
uniprot id: A0A7D4SVG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the porin LamB (TC 1.B.3) family.
messages: Membrane

349967:HRD69 RS15515
gene id: 349967:HRD69_RS15515
uniprot id: A0A7D4PGT2
names: Similarity
messages: Belongs to the ribulokinase family.

349967:HRD69 RS16085
gene id: 349967:HRD69_RS16085
uniprot id: A0A7D4TNT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Periplasm

349967:HRD69 RS19965
gene id: 349967:HRD69_RS19965
uniprot id: A0A7D4TQT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HscB family.
messages: Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA.
messages: Interacts with HscA and stimulates its ATPase activity. Interacts with IscU.

349967:HRD69 RS00885
gene id: 349967:HRD69_RS00885
uniprot id: A0A7D4SUT7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Cell inner membrane
messages: Homoheptamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.
messages: Membrane

349967:HRD69 RS09180
gene id: 349967:HRD69_RS09180
uniprot id: A0A7D4T222
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N-Me-Phe pilin family.
messages: Membrane

349967:HRD69 RS05885
gene id: 349967:HRD69_RS05885
uniprot id: A0A7D4TXN3
names: Similarity
messages: Belongs to the four-carbon acid sugar kinase family.

349967:HRD69 RS12390
gene id: 349967:HRD69_RS12390
uniprot id: A0A7D4SWC0
names: Similarity
names: Subunit
messages: Belongs to the MoaE family.
messages: Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis.

349967:HRD69 RS07575
gene id: 349967:HRD69_RS07575
uniprot id: A0A7D4U247
names: Function
names: Similarity
messages: Belongs to the UxaA family.
messages: Catalyzes the dehydration of galactarate to form 5-dehydro-4-deoxy-D-glucarate (5-KDG).

349967:HRD69 RS17225
gene id: 349967:HRD69_RS17225
uniprot id: A0A7D4U4N9
names: Similarity
messages: Belongs to the UPF0227 family.

349967:HRD69 RS19910
gene id: 349967:HRD69_RS19910
uniprot id: A0A7D4PAB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

349967:HRD69 RS07200
gene id: 349967:HRD69_RS07200
uniprot id: A0A7D4TFX5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GSP I family.
messages: Cell inner membrane
messages: Cleaved by prepilin peptidase.
messages: Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.
messages: Membrane
messages: Type II secretion is composed of four main components: the outer membrane complex, the inner membrane complex, the cytoplasmic secretion ATPase and the periplasm-spanning pseudopilus.

349967:HRD69 RS16525
gene id: 349967:HRD69_RS16525
uniprot id: A0A7D4T3D9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. MdtI subfamily.
messages: Catalyzes the excretion of spermidine.
messages: Cell membrane
messages: Forms a complex with MdtJ.
messages: Membrane

349967:HRD69 RS05410
gene id: 349967:HRD69_RS05410
uniprot id: A0A7D4P6Z9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

349967:HRD69 RS00550
gene id: 349967:HRD69_RS00550
uniprot id: A0A7D4PJK5
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.
messages: Belongs to the RecC family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

349967:HRD69 RS09185
gene id: 349967:HRD69_RS09185
uniprot id: A0A7D4TMV3
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

349967:HRD69 RS17860
gene id: 349967:HRD69_RS17860
uniprot id: A0A7D4T3N8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZapC family.
messages: Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ.
messages: Cytoplasm
messages: Interacts directly with FtsZ.

349967:HRD69 RS04650
gene id: 349967:HRD69_RS04650
uniprot id: A0A7D4P8Z4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer.

349967:HRD69 RS04475
gene id: 349967:HRD69_RS04475
uniprot id: A0A7D4TX73
names: Similarity
messages: Belongs to the phage antitermination Q type 1 family.

349967:HRD69 RS05450
gene id: 349967:HRD69_RS05450
uniprot id: A0A7D4SUX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

349967:HRD69 RS08745
gene id: 349967:HRD69_RS08745
uniprot id: A0A7D4SVL0
names: Similarity
names: Subunit
messages: Homotetramer.
messages: In the C-terminal section; belongs to the homoserine dehydrogenase family.
messages: In the N-terminal section; belongs to the aspartokinase family.

349967:HRD69 RS05610
gene id: 349967:HRD69_RS05610
uniprot id: A0A7D4PA49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

349967:HRD69 RS05280
gene id: 349967:HRD69_RS05280
uniprot id: A0A7D4P9C8
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

349967:HRD69 RS16025
gene id: 349967:HRD69_RS16025
uniprot id: A0A7D4U4A9
names: Cofactor
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.

349967:HRD69 RS02540
gene id: 349967:HRD69_RS02540
uniprot id: A0A7D4TYW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

349967:HRD69 RS13405
gene id: 349967:HRD69_RS13405
uniprot id: A0A7D4U3Q0
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT.
messages: Membrane

349967:HRD69 RS01680
gene id: 349967:HRD69_RS01680
uniprot id: A0A7D4SU54
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

349967:HRD69 RS06630
gene id: 349967:HRD69_RS06630
uniprot id: A0A7D4TXY2
names: Function
names: Similarity
messages: Belongs to the precorrin methyltransferase family.
messages: In the C-terminal section; belongs to the precorrin methyltransferase family.
messages: In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
messages: Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.

349967:HRD69 RS09135
gene id: 349967:HRD69_RS09135
uniprot id: A0A7D4P7W7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecM family.
messages: Periplasm
messages: Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation.
messages: cytosol

349967:HRD69 RS18350
gene id: 349967:HRD69_RS18350
uniprot id: A0A7D4P9V4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

349967:HRD69 RS16925
gene id: 349967:HRD69_RS16925
uniprot id: A0A7D4PIA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

349967:HRD69 RS10440
gene id: 349967:HRD69_RS10440
uniprot id: A0A7D4PAR4
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS11355
gene id: 349967:HRD69_RS11355
uniprot id: A0A7D4SWK6
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

349967:HRD69 RS05015
gene id: 349967:HRD69_RS05015
uniprot id: A0A7D4TLM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoid occlusion factor SlmA family.
messages: Homodimer. Interacts with FtsZ.
messages: Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
messages: nucleoid

349967:HRD69 RS08330
gene id: 349967:HRD69_RS08330
uniprot id: A0A7D4T6D6
names: Similarity
messages: Belongs to the ner transcriptional regulatory family.

349967:HRD69 RS13890
gene id: 349967:HRD69_RS13890
uniprot id: A0A7D4P4E2
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS20195
gene id: 349967:HRD69_RS20195
uniprot id: A0A7D4TNG6
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

349967:HRD69 RS01730
gene id: 349967:HRD69_RS01730
uniprot id: A0A7D4P0K8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
messages: Membrane

349967:HRD69 RS05465
gene id: 349967:HRD69_RS05465
uniprot id: A0A7D4T5T3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

349967:HRD69 RS06285
gene id: 349967:HRD69_RS06285
uniprot id: A0A7D4SV30
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS01945
gene id: 349967:HRD69_RS01945
uniprot id: A0A7D4TYR7
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS12815
gene id: 349967:HRD69_RS12815
uniprot id: A0A7D4PMF5
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS04115
gene id: 349967:HRD69_RS04115
uniprot id: A0A7D4TF93
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anaerobic G-3-P dehydrogenase subunit B family.
messages: Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.
messages: Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor.

349967:HRD69 RS08530
gene id: 349967:HRD69_RS08530
uniprot id: A0A7D4T1X8
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

349967:HRD69 RS02095
gene id: 349967:HRD69_RS02095
uniprot id: A0A7D4PNI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

349967:HRD69 RS11655
gene id: 349967:HRD69_RS11655
uniprot id: A0A7D4U3A6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TolB family.
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane.
messages: Periplasm
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

349967:HRD69 RS16600
gene id: 349967:HRD69_RS16600
uniprot id: A0A7D4P4U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

349967:HRD69 RS07015
gene id: 349967:HRD69_RS07015
uniprot id: A0A7D4PEY2
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

349967:HRD69 RS11055
gene id: 349967:HRD69_RS11055
uniprot id: A0A7D4TZ36
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

349967:HRD69 RS18440
gene id: 349967:HRD69_RS18440
uniprot id: A0A7D4P4D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

349967:HRD69 RS16945
gene id: 349967:HRD69_RS16945
uniprot id: A0A7D4P9L0
names: Similarity
messages: Belongs to the SIP oxidoreductase family.

349967:HRD69 RS07140
gene id: 349967:HRD69_RS07140
uniprot id: A0A7D4PQ58
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

349967:HRD69 RS16735
gene id: 349967:HRD69_RS16735
uniprot id: A0A7D4PH22
names: Similarity
messages: Belongs to the UPF0162 family.

349967:HRD69 RS13285
gene id: 349967:HRD69_RS13285
uniprot id: A0A7D4U3N8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS19880
gene id: 349967:HRD69_RS19880
uniprot id: A0A7D4U254
names: Similarity
messages: Belongs to the YfgM family.

349967:HRD69 RS07610
gene id: 349967:HRD69_RS07610
uniprot id: A0A7D4P356
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane
messages: Responsible for the transport of C4-dicarboxylates.

349967:HRD69 RS19575
gene id: 349967:HRD69_RS19575
uniprot id: A0A7D4U225
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
messages: Cell inner membrane
messages: Part of a tripartite efflux system composed of MdtA, MdtB and MdtC.

349967:HRD69 RS13610
gene id: 349967:HRD69_RS13610
uniprot id: A0A7D4SWJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CheZ family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P).

349967:HRD69 RS12330
gene id: 349967:HRD69_RS12330
uniprot id: A0A7D4P2X1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

349967:HRD69 RS16180
gene id: 349967:HRD69_RS16180
uniprot id: A0A7D4PGX7
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

349967:HRD69 RS14415
gene id: 349967:HRD69_RS14415
uniprot id: A0A7D4U1W0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DbpA subfamily.
messages: Contains an N-terminal domain that binds non-specifically to RNA and a C-terminal domain that binds specifically and tightly to hairpin 92 of 23S rRNA.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes.

349967:HRD69 RS00390
gene id: 349967:HRD69_RS00390
uniprot id: A0A7D4P0A7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

349967:HRD69 RS11600
gene id: 349967:HRD69_RS11600
uniprot id: A0A7D4PFV1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

349967:HRD69 RS02480
gene id: 349967:HRD69_RS02480
uniprot id: A0A7D4PQA2
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus membrane

349967:HRD69 RS02255
gene id: 349967:HRD69_RS02255
uniprot id: A0A7D4TL03
names: Similarity
messages: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.

349967:HRD69 RS13700
gene id: 349967:HRD69_RS13700
uniprot id: A0A7D4PMN3
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

349967:HRD69 RS20425
gene id: 349967:HRD69_RS20425
uniprot id: A0A7D4T460
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

349967:HRD69 RS18005
gene id: 349967:HRD69_RS18005
uniprot id: A0A7D4P8C6
names: Similarity
messages: Belongs to the asparaginase 1 family.

349967:HRD69 RS19270
gene id: 349967:HRD69_RS19270
uniprot id: A0A7D4PD54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ROK (NagC/XylR) family. NanK subfamily.
messages: Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P.
messages: Homodimer.

349967:HRD69 RS19445
gene id: 349967:HRD69_RS19445
uniprot id: A0A7D4P528
names: Subcellular Location Annotation
messages: Cytoplasm

349967:HRD69 RS11280
gene id: 349967:HRD69_RS11280
uniprot id: A0A7D4TKN7
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

349967:HRD69 RS10305
gene id: 349967:HRD69_RS10305
uniprot id: A0A7D4TKG5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrF family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.

349967:HRD69 RS18285
gene id: 349967:HRD69_RS18285
uniprot id: A0A7D4SXN3
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

349967:HRD69 RS08235
gene id: 349967:HRD69_RS08235
uniprot id: A0A7D4PAI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS17145
gene id: 349967:HRD69_RS17145
uniprot id: A0A7D4PDI0
names: Similarity
names: Subunit
messages: Belongs to the Nudix hydrolase family. NudJ subfamily.
messages: Monomer.

349967:HRD69 RS05375
gene id: 349967:HRD69_RS05375
uniprot id: A0A7D4TJ59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell membrane
messages: Membrane
messages: Responsible for the low-affinity transport of potassium into the cell. Likely operates as a K(+):H(+) symporter.

349967:HRD69 RS02875
gene id: 349967:HRD69_RS02875
uniprot id: A0A7D4U0H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZapG family.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS18095
gene id: 349967:HRD69_RS18095
uniprot id: A0A7D4TIV5
names: Subcellular Location Annotation
messages: Cytoplasm

349967:HRD69 RS08630
gene id: 349967:HRD69_RS08630
uniprot id: A0A7D4PLJ4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

349967:HRD69 RS19950
gene id: 349967:HRD69_RS19950
uniprot id: A0A7D4SY30
names: Function
names: Similarity
messages: Belongs to the IscX family.
messages: May function as iron donor in the assembly of iron-sulfur clusters.

349967:HRD69 RS10050
gene id: 349967:HRD69_RS10050
uniprot id: A0A7D4U0V3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

349967:HRD69 RS12425
gene id: 349967:HRD69_RS12425
uniprot id: A0A7D4U3H2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. RhlE subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA.

349967:HRD69 RS10830
gene id: 349967:HRD69_RS10830
uniprot id: A0A7D4T6W2
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

349967:HRD69 RS14215
gene id: 349967:HRD69_RS14215
uniprot id: A0A7D4PBM5
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

349967:HRD69 RS05445
gene id: 349967:HRD69_RS05445
uniprot id: A0A7D4SVL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

349967:HRD69 RS13240
gene id: 349967:HRD69_RS13240
uniprot id: A0A7D4SWX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

349967:HRD69 RS01405
gene id: 349967:HRD69_RS01405
uniprot id: A0A7D4P0I8
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

349967:HRD69 RS16320
gene id: 349967:HRD69_RS16320
uniprot id: A0A7D4T7Y0
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

349967:HRD69 RS19395
gene id: 349967:HRD69_RS19395
uniprot id: A0A7D4P7P7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M20A family. DapE subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
messages: Homodimer.

349967:HRD69 RS02970
gene id: 349967:HRD69_RS02970
uniprot id: A0A7D4TIJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RapZ-like family. RapZ subfamily.
messages: Homotrimer.
messages: Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6-phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS.

349967:HRD69 RS03890
gene id: 349967:HRD69_RS03890
uniprot id: A0A7D4TLD2
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

349967:HRD69 RS07700
gene id: 349967:HRD69_RS07700
uniprot id: A0A7D4P7J2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

349967:HRD69 RS09745
gene id: 349967:HRD69_RS09745
uniprot id: A0A7D4PFI9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

349967:HRD69 RS09055
gene id: 349967:HRD69_RS09055
uniprot id: A0A7D4PRZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

349967:HRD69 RS12185
gene id: 349967:HRD69_RS12185
uniprot id: A0A7D4T2P4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a regulator of flagellar gene expression by modulating the protein level of the anti sigma factor FlgM upon sensing ring completion or hook elongation. Flk could inhibit FlgM secretion by acting as a braking system for the flagellar-associated type III secretion system.
messages: Belongs to the flk family.
messages: Cell inner membrane

349967:HRD69 RS12545
gene id: 349967:HRD69_RS12545
uniprot id: A0A7D4PC83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

349967:HRD69 RS09775
gene id: 349967:HRD69_RS09775
uniprot id: A0A7D4T6P9
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

349967:HRD69 RS17450
gene id: 349967:HRD69_RS17450
uniprot id: A0A7D4U2K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

349967:HRD69 RS19305
gene id: 349967:HRD69_RS19305
uniprot id: A0A7D4PUB9
names: Similarity
messages: Belongs to the acetyltransferase family. YpeA subfamily.

349967:HRD69 RS18070
gene id: 349967:HRD69_RS18070
uniprot id: A0A7D4SXQ5
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS09175
gene id: 349967:HRD69_RS09175
uniprot id: A0A7D4SVP2
names: Similarity
messages: Belongs to the GSP E family.

349967:HRD69 RS16090
gene id: 349967:HRD69_RS16090
uniprot id: A0A7D4SXD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

349967:HRD69 RS09245
gene id: 349967:HRD69_RS09245
uniprot id: A0A7D4P5B9
names: Similarity
messages: Belongs to the UPF0231 family.

349967:HRD69 RS06865
gene id: 349967:HRD69_RS06865
uniprot id: A0A7D4U1Y6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

349967:HRD69 RS03130
gene id: 349967:HRD69_RS03130
uniprot id: A0A7D4PNS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease N1/T1 family.
messages: Secreted

349967:HRD69 RS14770
gene id: 349967:HRD69_RS14770
uniprot id: A0A7D4PCV5
names: Similarity
messages: Belongs to the transglycosylase Slt family.

349967:HRD69 RS05865
gene id: 349967:HRD69_RS05865
uniprot id: A0A7D4TLZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers. Binds only one seryl-tRNA(Sec) per dimer.

349967:HRD69 RS13565
gene id: 349967:HRD69_RS13565
uniprot id: A0A7D4P6C9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

349967:HRD69 RS01745
gene id: 349967:HRD69_RS01745
uniprot id: A0A7D4P6B1
names: Similarity
messages: Belongs to the peptidase A24 family.

349967:HRD69 RS09440
gene id: 349967:HRD69_RS09440
uniprot id: A0A7D4TKB1
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS07830
gene id: 349967:HRD69_RS07830
uniprot id: A0A7D4P4T7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

349967:HRD69 RS18785
gene id: 349967:HRD69_RS18785
uniprot id: A0A7D4PD07
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS16760
gene id: 349967:HRD69_RS16760
uniprot id: A0A7D4TPS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LolB family.
messages: Cell outer membrane
messages: Membrane
messages: Monomer.
messages: Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.

349967:HRD69 RS15180
gene id: 349967:HRD69_RS15180
uniprot id: A0A7D4PDX8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the anthranilate synthase component I family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

349967:HRD69 RS02935
gene id: 349967:HRD69_RS02935
uniprot id: A0A7D4PKA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate.
messages: Homotetramer.

349967:HRD69 RS15695
gene id: 349967:HRD69_RS15695
uniprot id: A0A7D4U484
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase family.

349967:HRD69 RS12975
gene id: 349967:HRD69_RS12975
uniprot id: A0A7D4P327
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
messages: Homodimer.

349967:HRD69 RS18180
gene id: 349967:HRD69_RS18180
uniprot id: A0A7D4T3Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane

349967:HRD69 RS00965
gene id: 349967:HRD69_RS00965
uniprot id: A0A7D4PN76
names: Similarity
messages: Belongs to the UPF0301 (AlgH) family.

349967:HRD69 RS16495
gene id: 349967:HRD69_RS16495
uniprot id: A0A7D4U5N4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase D family.
messages: Cytoplasm
messages: Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides.

349967:HRD69 RS07080
gene id: 349967:HRD69_RS07080
uniprot id: A0A7D4TFW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell inner membrane
messages: Membrane
messages: Transports acetate.

349967:HRD69 RS19890
gene id: 349967:HRD69_RS19890
uniprot id: A0A7D4U359
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

349967:HRD69 RS00660
gene id: 349967:HRD69_RS00660
uniprot id: A0A7D4SUR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Cell inner membrane

349967:HRD69 RS00535
gene id: 349967:HRD69_RS00535
uniprot id: A0A7D4PN33
names: Function
names: Similarity
names: Subunit
messages: A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD.
messages: Belongs to the RecD family.
messages: Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.

349967:HRD69 RS17045
gene id: 349967:HRD69_RS17045
uniprot id: A0A7D4PDG7
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

349967:HRD69 RS06220
gene id: 349967:HRD69_RS06220
uniprot id: A0A7D4U1S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal stress protein A family.
messages: Cytoplasm

349967:HRD69 RS16595
gene id: 349967:HRD69_RS16595
uniprot id: A0A7D4P714
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

349967:HRD69 RS01045
gene id: 349967:HRD69_RS01045
uniprot id: A0A7D4P810
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Monomer.

349967:HRD69 RS05840
gene id: 349967:HRD69_RS05840
uniprot id: A0A7D4PEP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

349967:HRD69 RS11955
gene id: 349967:HRD69_RS11955
uniprot id: A0A7D4SWN7
names: Similarity
messages: Belongs to the UPF0303 family.

349967:HRD69 RS05765
gene id: 349967:HRD69_RS05765
uniprot id: A0A7D4TLY7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

349967:HRD69 RS17810
gene id: 349967:HRD69_RS17810
uniprot id: A0A7D4PDP5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioester dehydratase family. FabA subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.

349967:HRD69 RS12180
gene id: 349967:HRD69_RS12180
uniprot id: A0A7D4SWA7
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS04455
gene id: 349967:HRD69_RS04455
uniprot id: A0A7D4TLH8
names: Function
messages: Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria.

349967:HRD69 RS06260
gene id: 349967:HRD69_RS06260
uniprot id: A0A7D4PPP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

349967:HRD69 RS01960
gene id: 349967:HRD69_RS01960
uniprot id: A0A7D4P965
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.
messages: Homooctamer.

349967:HRD69 RS20220
gene id: 349967:HRD69_RS20220
uniprot id: A0A7D4PDE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

349967:HRD69 RS03850
gene id: 349967:HRD69_RS03850
uniprot id: A0A7D4P2C9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RfaH family.
messages: Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound, RfaH suppresses pausing and inhibits Rho-dependent and intrinsic termination at a subset of sites. Termination signals are bypassed, which allows complete synthesis of long RNA chains.
messages: Interacts with both the nontemplate DNA and the RNA polymerase (RNAP).

349967:HRD69 RS09620
gene id: 349967:HRD69_RS09620
uniprot id: A0A7D4PLS6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Homodimer.

349967:HRD69 RS04730
gene id: 349967:HRD69_RS04730
uniprot id: A0A7D4TXC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

349967:HRD69 RS13805
gene id: 349967:HRD69_RS13805
uniprot id: A0A7D4PMN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

349967:HRD69 RS16585
gene id: 349967:HRD69_RS16585
uniprot id: A0A7D4P514
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

349967:HRD69 RS03300
gene id: 349967:HRD69_RS03300
uniprot id: A0A7D4PUM5
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS00475
gene id: 349967:HRD69_RS00475
uniprot id: A0A7D4TW26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0382 family.
messages: Membrane

349967:HRD69 RS15590
gene id: 349967:HRD69_RS15590
uniprot id: A0A7D4PC54
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

349967:HRD69 RS05770
gene id: 349967:HRD69_RS05770
uniprot id: A0A7D4T5V8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

349967:HRD69 RS19985
gene id: 349967:HRD69_RS19985
uniprot id: A0A7D4TND7
names: Cofactor
names: Function
messages: Binds 1 [2Fe-2S] cluster.
messages: Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins.

349967:HRD69 RS10345
gene id: 349967:HRD69_RS10345
uniprot id: A0A7D4P5L5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Crl family.
messages: Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32.
messages: Cytoplasm

349967:HRD69 RS05435
gene id: 349967:HRD69_RS05435
uniprot id: A0A7D4PEK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

349967:HRD69 RS17300
gene id: 349967:HRD69_RS17300
uniprot id: A0A7D4SXK9
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS05240
gene id: 349967:HRD69_RS05240
uniprot id: A0A7D4TLP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0761 family.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS10475
gene id: 349967:HRD69_RS10475
uniprot id: A0A7D4U5J0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

349967:HRD69 RS05490
gene id: 349967:HRD69_RS05490
uniprot id: A0A7D4TZS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

349967:HRD69 RS05270
gene id: 349967:HRD69_RS05270
uniprot id: A0A7D4TZQ4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

349967:HRD69 RS19405
gene id: 349967:HRD69_RS19405
uniprot id: A0A7D4PTT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0370 family.
messages: Cell membrane

349967:HRD69 RS09625
gene id: 349967:HRD69_RS09625
uniprot id: A0A7D4SWB7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).

349967:HRD69 RS06150
gene id: 349967:HRD69_RS06150
uniprot id: A0A7D4P2T0
names: Similarity
messages: Belongs to the peptidase M16 family.

349967:HRD69 RS08810
gene id: 349967:HRD69_RS08810
uniprot id: A0A7D4P7U0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS14890
gene id: 349967:HRD69_RS14890
uniprot id: A0A7D4PBW0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS10570
gene id: 349967:HRD69_RS10570
uniprot id: A0A7D4P3R7
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS01590
gene id: 349967:HRD69_RS01590
uniprot id: A0A7D4TI82
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

349967:HRD69 RS13830
gene id: 349967:HRD69_RS13830
uniprot id: A0A7D4TP29
names: Similarity
messages: Belongs to the ACC deaminase/D-cysteine desulfhydrase family.

349967:HRD69 RS11255
gene id: 349967:HRD69_RS11255
uniprot id: A0A7D4SW33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RlpA family.
messages: Cell membrane
messages: Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.

349967:HRD69 RS08910
gene id: 349967:HRD69_RS08910
uniprot id: A0A7D4PBC2
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
messages: Periplasm
messages: The PPIase activity resides only in the second parvulin domain. The N-terminal region and the C-terminal tail are necessary and sufficient for the chaperone activity of SurA. The PPIase activity is dispensable for SurA to function as a chaperone. The N-terminal region and the C-terminal tail are also required for porin recognition.

349967:HRD69 RS12405
gene id: 349967:HRD69_RS12405
uniprot id: A0A7D4T775
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS11125
gene id: 349967:HRD69_RS11125
uniprot id: A0A7D4SWJ3
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

349967:HRD69 RS03720
gene id: 349967:HRD69_RS03720
uniprot id: A0A7D4PKI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

349967:HRD69 RS15095
gene id: 349967:HRD69_RS15095
uniprot id: A0A7D4T356
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.
messages: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS08105
gene id: 349967:HRD69_RS08105
uniprot id: A0A7D4TG83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase U32 family. UbiV subfamily.
messages: Forms an heterodimer with UbiU.
messages: Required for O(2)-independent ubiquinone (coenzyme Q) biosynthesis. Together with UbiU, is essential for the C6-hydroxylation reaction in the oxygen-independent ubiquinone biosynthesis pathway.

349967:HRD69 RS08455
gene id: 349967:HRD69_RS08455
uniprot id: A0A7D4TYG4
names: Cofactor
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.

349967:HRD69 RS11275
gene id: 349967:HRD69_RS11275
uniprot id: A0A7D4TGY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

349967:HRD69 RS05005
gene id: 349967:HRD69_RS05005
uniprot id: A0A7D4SUU7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS15300
gene id: 349967:HRD69_RS15300
uniprot id: A0A7D4PMY4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LapA family.
messages: Cell inner membrane
messages: Involved in the assembly of lipopolysaccharide (LPS).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS09905
gene id: 349967:HRD69_RS09905
uniprot id: A0A7D4TKD9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Catalyzes the reversible hydration of fumarate to (S)-malate.
messages: Homodimer.

349967:HRD69 RS13190
gene id: 349967:HRD69_RS13190
uniprot id: A0A7D4P393
names: Similarity
messages: Belongs to the CobH/CbiC family.

349967:HRD69 RS06160
gene id: 349967:HRD69_RS06160
uniprot id: A0A7D4PR59
names: Similarity
messages: Belongs to the 4-oxalocrotonate tautomerase family.

349967:HRD69 RS10500
gene id: 349967:HRD69_RS10500
uniprot id: A0A7D4T2B0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

349967:HRD69 RS20100
gene id: 349967:HRD69_RS20100
uniprot id: A0A7D4U275
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).
messages: Homodimer.

349967:HRD69 RS04015
gene id: 349967:HRD69_RS04015
uniprot id: A0A7D4TF90
names: Similarity
messages: Belongs to the ABC transporter superfamily.

349967:HRD69 RS18900
gene id: 349967:HRD69_RS18900
uniprot id: A0A7D4PE91
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS18915
gene id: 349967:HRD69_RS18915
uniprot id: A0A7D4P5A8
uniprot id: C4SGN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms a 1:1 complex with cognate immunity protein CdiI.
messages: In the C-terminal section; belongs to the bacterial EndoU family.
messages: In the N-terminal section; belongs to the CdiA toxin family.
messages: Secreted
messages: The CdiA protein is thought to be exported from the cell through the central lumen of CdiB, the other half of its two-partner system (TPS). The TPS domain probably remains associated with CdiB while the FHA-1 domain forms an extended filament with the receptor-binding domain (RBD) at its extremity; in the secretion arrested state the C-terminus of the RBD and YP domains form a hairpin-like structure as the FHA-2, PT and CT domains are periplasmic. The YP domain is probably responsible for this arrest at the point where it re-enters the host cell periplasm. Upon binding to a target cell outer membrane receptor a signal is transmitted to activate secretion. The filament elongates slightly, the rest of CdiA is secreted and the FHA-2 domain becomes stably associated with the target cell's outer membrane where it facilitates entry of the toxic CT domain into the target cell periplasm. From there the toxic CT domain is cleaved and gains access to the target cell cytoplasm via an inner membrane protein.
messages: Toxic component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion. Targeting of the CT domain (residues 2824-2963) in the absence of immunity protein inhibits cell growth and causes tRNA(UUC-Glu) cleavage in the anticodon loop; expression of cognate immunity protein CdiI-43969 neutralizes growth inhibition and tRNA(UUC-Glu) remains intact, whereas non-cognate immunity proteins do not confer protection from the toxic effects.
messages: target cell cytoplasm

349967:HRD69 RS13345
gene id: 349967:HRD69_RS13345
uniprot id: A0A7D4PG84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

349967:HRD69 RS00865
gene id: 349967:HRD69_RS00865
uniprot id: A0A7D4PPX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

349967:HRD69 RS03575
gene id: 349967:HRD69_RS03575
uniprot id: A0A7D4PKG7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MetA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.

349967:HRD69 RS19165
gene id: 349967:HRD69_RS19165
uniprot id: A0A7D4PEB9
names: Subcellular Location Annotation
messages: Cell inner membrane

349967:HRD69 RS05350
gene id: 349967:HRD69_RS05350
uniprot id: A0A7D4SUW6
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

349967:HRD69 RS04355
gene id: 349967:HRD69_RS04355
uniprot id: A0A7D4TX64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. RhlB subfamily.
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA.

349967:HRD69 RS20150
gene id: 349967:HRD69_RS20150
uniprot id: A0A7D4PUJ0
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

349967:HRD69 RS03400
gene id: 349967:HRD69_RS03400
uniprot id: A0A7D4TWY4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS08045
gene id: 349967:HRD69_RS08045
uniprot id: A0A7D4P4Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

349967:HRD69 RS01015
gene id: 349967:HRD69_RS01015
uniprot id: A0A7D4TI41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

349967:HRD69 RS16745
gene id: 349967:HRD69_RS16745
uniprot id: A0A7D4SXH3
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

349967:HRD69 RS03820
gene id: 349967:HRD69_RS03820
uniprot id: A0A7D4P0Y2
names: Similarity
messages: Belongs to the IMPACT family.

349967:HRD69 RS05575
gene id: 349967:HRD69_RS05575
uniprot id: A0A7D4TFI5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TER reductase family.
messages: Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).
messages: Monomer.

349967:HRD69 RS13795
gene id: 349967:HRD69_RS13795
uniprot id: A0A7D4PSY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FliT family.
messages: Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD. As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus.
messages: Homodimer. Interacts with FliD and FlhC.
messages: cytosol

349967:HRD69 RS19540
gene id: 349967:HRD69_RS19540
uniprot id: A0A7D4PF07
names: Similarity
messages: Belongs to the heat shock protein 70 family.

349967:HRD69 RS00985
gene id: 349967:HRD69_RS00985
uniprot id: A0A7D4SUU5
names: Similarity
messages: Belongs to the GSP E family.

349967:HRD69 RS17230
gene id: 349967:HRD69_RS17230
uniprot id: A0A7D4U2I2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.
messages: Cytoplasm
messages: Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.

349967:HRD69 RS06935
gene id: 349967:HRD69_RS06935
uniprot id: A0A7D4T1J3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

349967:HRD69 RS06920
gene id: 349967:HRD69_RS06920
uniprot id: A0A7D4PL65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

349967:HRD69 RS15755
gene id: 349967:HRD69_RS15755
uniprot id: A0A7D4SXC5
names: Function
names: Similarity
messages: Belongs to the AMP nucleosidase family.
messages: Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations.

349967:HRD69 RS14855
gene id: 349967:HRD69_RS14855
uniprot id: A0A7D4T7N7
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

349967:HRD69 RS08790
gene id: 349967:HRD69_RS08790
uniprot id: A0A7D4U0J4
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

349967:HRD69 RS11445
gene id: 349967:HRD69_RS11445
uniprot id: A0A7D4PBY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Cell inner membrane

349967:HRD69 RS06265
gene id: 349967:HRD69_RS06265
uniprot id: A0A7D4PR68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fimbrial export usher family.
messages: Cell outer membrane
messages: Membrane

349967:HRD69 RS14950
gene id: 349967:HRD69_RS14950
uniprot id: A0A7D4T348
names: Similarity
messages: Belongs to the asparaginase 1 family.

349967:HRD69 RS11735
gene id: 349967:HRD69_RS11735
uniprot id: A0A7D4PM57
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 Fe cation per subunit.
messages: Binds 1 zinc ion per subunit.

349967:HRD69 RS10200
gene id: 349967:HRD69_RS10200
uniprot id: A0A7D4TYV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

349967:HRD69 RS15325
gene id: 349967:HRD69_RS15325
uniprot id: A0A7D4TPF2
names: Similarity
messages: Belongs to the SUI1 family.

349967:HRD69 RS12490
gene id: 349967:HRD69_RS12490
uniprot id: A0A7D4SWC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

349967:HRD69 RS12085
gene id: 349967:HRD69_RS12085
uniprot id: A0A7D4TNI6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RcsD family.
messages: Cell inner membrane
messages: Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB.
messages: Interacts with RcsC and RcsB.
messages: Phosphorylated by RcsC.

349967:HRD69 RS09510
gene id: 349967:HRD69_RS09510
uniprot id: A0A7D4PFH3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

349967:HRD69 RS10240
gene id: 349967:HRD69_RS10240
uniprot id: A0A7D4P865
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methylthioribose kinase family.
messages: Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate.
messages: Homodimer.

349967:HRD69 RS07605
gene id: 349967:HRD69_RS07605
uniprot id: A0A7D4P4R9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CutA family.
messages: Binds 1 copper ion per subunit.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in resistance toward heavy metals.

349967:HRD69 RS12765
gene id: 349967:HRD69_RS12765
uniprot id: A0A7D4P308
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Part of an ABC transporter complex involved in carbohydrate import. Could be involved in ribose, galactose and/or methyl galactoside import. Responsible for energy coupling to the transport system.

349967:HRD69 RS06555
gene id: 349967:HRD69_RS06555
uniprot id: A0A7D4P4F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IgaA family.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS04300
gene id: 349967:HRD69_RS04300
uniprot id: A0A7D4PP32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the polysaccharide transport (PST) (TC 2.A.66.2) family.
messages: Cell inner membrane
messages: Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA).
messages: Membrane
messages: Probably part of a complex composed of WzxE, WzyE and WzzE.

349967:HRD69 RS03100
gene id: 349967:HRD69_RS03100
uniprot id: A0A7D4P8M6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rnk family.
messages: Interacts with the RNA polymerase.
messages: May act as an anti-Gre factor.

349967:HRD69 RS18170
gene id: 349967:HRD69_RS18170
uniprot id: A0A7D4SXR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS00280
gene id: 349967:HRD69_RS00280
uniprot id: A0A7D4P7Z1
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

349967:HRD69 RS06975
gene id: 349967:HRD69_RS06975
uniprot id: A0A7D4P1P0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

349967:HRD69 RS11250
gene id: 349967:HRD69_RS11250
uniprot id: A0A7D4SWK0
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

349967:HRD69 RS12170
gene id: 349967:HRD69_RS12170
uniprot id: A0A7D4PM83
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

349967:HRD69 RS13340
gene id: 349967:HRD69_RS13340
uniprot id: A0A7D4PSV1
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

349967:HRD69 RS04765
gene id: 349967:HRD69_RS04765
uniprot id: A0A7D4P3Y1
names: Similarity
messages: Belongs to the FBPase class 2 family.

349967:HRD69 RS17445
gene id: 349967:HRD69_RS17445
uniprot id: A0A7D4U4Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS01595
gene id: 349967:HRD69_RS01595
uniprot id: A0A7D4TWE9
names: Similarity
messages: Belongs to the HupJ family.

349967:HRD69 RS14815
gene id: 349967:HRD69_RS14815
uniprot id: A0A7D4PGJ2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

349967:HRD69 RS06355
gene id: 349967:HRD69_RS06355
uniprot id: A0A7D4P4C8
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

349967:HRD69 RS01535
gene id: 349967:HRD69_RS01535
uniprot id: A0A7D4P1X3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial microcompartment
messages: Belongs to the EutB family.
messages: Binds between the large and small subunits.
messages: Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of vitamin B12.
messages: The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards.

349967:HRD69 RS00715
gene id: 349967:HRD69_RS00715
uniprot id: A0A7D4P7Y8
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS19100
gene id: 349967:HRD69_RS19100
uniprot id: A0A7D4T3V8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

349967:HRD69 RS07010
gene id: 349967:HRD69_RS07010
uniprot id: A0A7D4PRD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

349967:HRD69 RS02185
gene id: 349967:HRD69_RS02185
uniprot id: A0A7D4P0N9
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

349967:HRD69 RS11620
gene id: 349967:HRD69_RS11620
uniprot id: A0A7D4T2K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

349967:HRD69 RS02405
gene id: 349967:HRD69_RS02405
uniprot id: A0A7D4TIE5
names: Similarity
messages: Belongs to the pirin family.

349967:HRD69 RS16790
gene id: 349967:HRD69_RS16790
uniprot id: A0A7D4U2F1
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

349967:HRD69 RS14255
gene id: 349967:HRD69_RS14255
uniprot id: A0A7D4PMQ8
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

349967:HRD69 RS10095
gene id: 349967:HRD69_RS10095
uniprot id: A0A7D4PQZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamD family.
messages: Cell outer membrane
messages: Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery.

349967:HRD69 RS06475
gene id: 349967:HRD69_RS06475
uniprot id: A0A7D4PEU2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NfuA family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is presumably bound at the interface of two monomers.
messages: Homodimer.
messages: Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.

349967:HRD69 RS13475
gene id: 349967:HRD69_RS13475
uniprot id: A0A7D4PML5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtfA family.
messages: Cytoplasm
messages: Interacts with Mlc.
messages: Involved in the regulation of ptsG expression by binding and inactivating Mlc.

349967:HRD69 RS00490
gene id: 349967:HRD69_RS00490
uniprot id: A0A7D4P0B7
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

349967:HRD69 RS04280
gene id: 349967:HRD69_RS04280
uniprot id: A0A7D4P9S0
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS00645
gene id: 349967:HRD69_RS00645
uniprot id: A0A7D4PPT2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

349967:HRD69 RS15035
gene id: 349967:HRD69_RS15035
uniprot id: A0A7D4PCX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone-like protein H-NS family.
messages: nucleoid

349967:HRD69 RS00165
gene id: 349967:HRD69_RS00165
uniprot id: A0A7D4P608
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPS (TC 1.B.20) family.
messages: Cell outer membrane
messages: Membrane

349967:HRD69 RS05805
gene id: 349967:HRD69_RS05805
uniprot id: A0A7D4P9H3
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

349967:HRD69 RS15130
gene id: 349967:HRD69_RS15130
uniprot id: A0A7D4U204
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

349967:HRD69 RS20095
gene id: 349967:HRD69_RS20095
uniprot id: A0A7D4TNF6
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase Slt family.
messages: Cell outer membrane
messages: In the C-terminal section; belongs to the transglycosylase Slt family.
messages: In the N-terminal section; belongs to the bacterial solute-binding protein 3 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.
messages: The N-terminal domain does not have lytic activity and probably modulates enzymatic activity. The C-terminal domain is the catalytic active domain.

349967:HRD69 RS01920
gene id: 349967:HRD69_RS01920
uniprot id: A0A7D4TIA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiK family.
messages: Cytoplasm
messages: Required for efficient ubiquinone (coenzyme Q) biosynthesis. UbiK is probably an accessory factor of Ubi enzymes and facilitates ubiquinone biosynthesis by acting as an assembly factor, a targeting factor, or both.

349967:HRD69 RS10635
gene id: 349967:HRD69_RS10635
uniprot id: A0A7D4U312
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

349967:HRD69 RS02065
gene id: 349967:HRD69_RS02065
uniprot id: A0A7D4P0N3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The M ring is integral to the inner membrane of the cell and may be connected to the flagellar rod via the S ring. The S (supramembrane ring) lies just distal to the M ring. The L and P rings lie in the outer membrane and the periplasmic space, respectively.

349967:HRD69 RS09325
gene id: 349967:HRD69_RS09325
uniprot id: A0A7D4TGI5
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

349967:HRD69 RS08095
gene id: 349967:HRD69_RS08095
uniprot id: A0A7D4TML3
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS02800
gene id: 349967:HRD69_RS02800
uniprot id: A0A7D4P3K7
names: Similarity
messages: Belongs to the UPF0102 family.

349967:HRD69 RS06830
gene id: 349967:HRD69_RS06830
uniprot id: A0A7D4SV70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

349967:HRD69 RS16325
gene id: 349967:HRD69_RS16325
uniprot id: A0A7D4TIE9
names: Similarity
messages: Belongs to the HesB/IscA family.

349967:HRD69 RS08715
gene id: 349967:HRD69_RS08715
uniprot id: A0A7D4PQJ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YjjX NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

349967:HRD69 RS17390
gene id: 349967:HRD69_RS17390
uniprot id: A0A7D4PH68
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Homodimer.

349967:HRD69 RS18030
gene id: 349967:HRD69_RS18030
uniprot id: A0A7D4P9S5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. YcaD (TC 2.A.1.26) family.
messages: Cell inner membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

349967:HRD69 RS15890
gene id: 349967:HRD69_RS15890
uniprot id: A0A7D4T7V3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

349967:HRD69 RS05905
gene id: 349967:HRD69_RS05905
uniprot id: A0A7D4P9I3
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS13085
gene id: 349967:HRD69_RS13085
uniprot id: A0A7D4P338
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial microcompartment
messages: Belongs to the bacterial microcompartments protein family.

349967:HRD69 RS11400
gene id: 349967:HRD69_RS11400
uniprot id: A0A7D4TNC1
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.

349967:HRD69 RS14025
gene id: 349967:HRD69_RS14025
uniprot id: A0A7D4PGD5
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

349967:HRD69 RS10935
gene id: 349967:HRD69_RS10935
uniprot id: A0A7D4T6X1
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS08840
gene id: 349967:HRD69_RS08840
uniprot id: A0A7D4PFC2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

349967:HRD69 RS17745
gene id: 349967:HRD69_RS17745
uniprot id: A0A7D4PNJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RlmI family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA.

349967:HRD69 RS06545
gene id: 349967:HRD69_RS06545
uniprot id: A0A7D4PAG5
names: Similarity
messages: Belongs to the HSP15 family.

349967:HRD69 RS12445
gene id: 349967:HRD69_RS12445
uniprot id: A0A7D4PC74
names: Similarity
messages: Belongs to the peptidase S11 family.

349967:HRD69 RS16665
gene id: 349967:HRD69_RS16665
uniprot id: A0A7D4U0U8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

349967:HRD69 RS08055
gene id: 349967:HRD69_RS08055
uniprot id: A0A7D4PQD6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

349967:HRD69 RS18215
gene id: 349967:HRD69_RS18215
uniprot id: A0A7D4U4Y6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

349967:HRD69 RS08380
gene id: 349967:HRD69_RS08380
uniprot id: A0A7D4P7Q2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).

349967:HRD69 RS15385
gene id: 349967:HRD69_RS15385
uniprot id: A0A7D4P6S4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

349967:HRD69 RS18015
gene id: 349967:HRD69_RS18015
uniprot id: A0A7D4P496
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

349967:HRD69 RS03340
gene id: 349967:HRD69_RS03340
uniprot id: A0A7D4PNU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).

349967:HRD69 RS17845
gene id: 349967:HRD69_RS17845
uniprot id: A0A7D4PNK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily.
messages: Cytoplasm
messages: Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA and has ATPase activity.

349967:HRD69 RS08100
gene id: 349967:HRD69_RS08100
uniprot id: A0A7D4T6C0
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS02225
gene id: 349967:HRD69_RS02225
uniprot id: A0A7D4PQ78
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

349967:HRD69 RS04755
gene id: 349967:HRD69_RS04755
uniprot id: A0A7D4P9W3
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

349967:HRD69 RS05415
gene id: 349967:HRD69_RS05415
uniprot id: A0A7D4P448
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.

349967:HRD69 RS20215
gene id: 349967:HRD69_RS20215
uniprot id: A0A7D4P4S8
names: Function
messages: Acts as a radical domain for damaged PFL and possibly other radical proteins.

349967:HRD69 RS18295
gene id: 349967:HRD69_RS18295
uniprot id: A0A7D4TQE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

349967:HRD69 RS04335
gene id: 349967:HRD69_RS04335
uniprot id: A0A7D4TLG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WzzB/Cld/Rol family.
messages: Cell inner membrane
messages: Membrane
messages: Modulates the polysaccharide chain length of enterobacterial common antigen (ECA).
messages: Probably part of a complex composed of WzxE, WzyE and WzzE.

349967:HRD69 RS05140
gene id: 349967:HRD69_RS05140
uniprot id: A0A7D4T5R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

349967:HRD69 RS15585
gene id: 349967:HRD69_RS15585
uniprot id: A0A7D4P3R6
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

349967:HRD69 RS17335
gene id: 349967:HRD69_RS17335
uniprot id: A0A7D4U169
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

349967:HRD69 RS07940
gene id: 349967:HRD69_RS07940
uniprot id: A0A7D4P380
names: Similarity
messages: Belongs to the ner transcriptional regulatory family.

349967:HRD69 RS17380
gene id: 349967:HRD69_RS17380
uniprot id: A0A7D4PT63
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase E/G family. RNase E subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per homotetramer.
messages: Cell inner membrane
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation. Within the RNA degradosome, RNase E assembles into a homotetramer formed by a dimer of dimers.
messages: Cytoplasm
messages: Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs.

349967:HRD69 RS12505
gene id: 349967:HRD69_RS12505
uniprot id: A0A7D4T785
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).

349967:HRD69 RS14690
gene id: 349967:HRD69_RS14690
uniprot id: A0A7D4PGI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

349967:HRD69 RS05295
gene id: 349967:HRD69_RS05295
uniprot id: A0A7D4P440
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response.
messages: Belongs to the SrkA/RdoA protein kinase family.
messages: Cytoplasm
messages: Monomer.

349967:HRD69 RS00365
gene id: 349967:HRD69_RS00365
uniprot id: A0A7D4TEH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamA family.
messages: Cell outer membrane
messages: Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE.
messages: Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery.

349967:HRD69 RS05290
gene id: 349967:HRD69_RS05290
uniprot id: A0A7D4P6Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbA subfamily.
messages: Periplasm

349967:HRD69 RS06215
gene id: 349967:HRD69_RS06215
uniprot id: A0A7D4TXR4
names: Function
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.

349967:HRD69 RS06815
gene id: 349967:HRD69_RS06815
uniprot id: A0A7D4PEW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DsrH/TusB family.
messages: Cytoplasm
messages: Heterohexamer, formed by a dimer of trimers. The hexameric TusBCD complex contains 2 copies each of TusB, TusC and TusD. The TusBCD complex interacts with TusE.
messages: Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.

349967:HRD69 RS00970
gene id: 349967:HRD69_RS00970
uniprot id: A0A7D4PPY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

349967:HRD69 RS10530
gene id: 349967:HRD69_RS10530
uniprot id: A0A7D4U301
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).

349967:HRD69 RS00795
gene id: 349967:HRD69_RS00795
uniprot id: A0A7D4TEK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-modifying YgfZ family.
messages: Cytoplasm
messages: Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication.

349967:HRD69 RS17880
gene id: 349967:HRD69_RS17880
uniprot id: A0A7D4TMC4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

349967:HRD69 RS19885
gene id: 349967:HRD69_RS19885
uniprot id: A0A7D4U5A6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

349967:HRD69 RS03780
gene id: 349967:HRD69_RS03780
uniprot id: A0A7D4TIR1
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
messages: Belongs to the biotin--protein ligase family.

349967:HRD69 RS10575
gene id: 349967:HRD69_RS10575
uniprot id: A0A7D4PR98
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Membrane

349967:HRD69 RS19600
gene id: 349967:HRD69_RS19600
uniprot id: A0A7D4PEF3
names: Similarity
messages: Belongs to the UPF0339 family. Duplicated subfamily.

349967:HRD69 RS08980
gene id: 349967:HRD69_RS08980
uniprot id: A0A7D4T6I3
names: Similarity
messages: Belongs to the organic radical-activating enzymes family.

349967:HRD69 RS02210
gene id: 349967:HRD69_RS02210
uniprot id: A0A7D4P3G5
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

349967:HRD69 RS20065
gene id: 349967:HRD69_RS20065
uniprot id: A0A7D4SY10
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
messages: In the C-terminal section; belongs to the NAD synthetase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS10640
gene id: 349967:HRD69_RS10640
uniprot id: A0A7D4U114
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

349967:HRD69 RS20245
gene id: 349967:HRD69_RS20245
uniprot id: A0A7D4PU21
names: Similarity
messages: Belongs to the UPF0125 (RnfH) family.

349967:HRD69 RS00845
gene id: 349967:HRD69_RS00845
uniprot id: A0A7D4P372
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.
messages: Belongs to the ZapA family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

349967:HRD69 RS08000
gene id: 349967:HRD69_RS08000
uniprot id: A0A7D4TYC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

349967:HRD69 RS18705
gene id: 349967:HRD69_RS18705
uniprot id: A0A7D4P594
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities.
messages: Cytoplasm
messages: Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI).
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

349967:HRD69 RS15505
gene id: 349967:HRD69_RS15505
uniprot id: A0A7D4PSQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3.A.1.109) family.
messages: Membrane

349967:HRD69 RS12870
gene id: 349967:HRD69_RS12870
uniprot id: A0A7D4U1G6
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS14335
gene id: 349967:HRD69_RS14335
uniprot id: A0A7D4P6K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transpeptidase family. FtsI subfamily.
messages: Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.
messages: Cell inner membrane

349967:HRD69 RS06145
gene id: 349967:HRD69_RS06145
uniprot id: A0A7D4P4B0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate across the membrane.

349967:HRD69 RS02235
gene id: 349967:HRD69_RS02235
uniprot id: A0A7D4PK23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FlgA family.
messages: Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly.
messages: Periplasm

349967:HRD69 RS14600
gene id: 349967:HRD69_RS14600
uniprot id: A0A7D4SWR4
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS16380
gene id: 349967:HRD69_RS16380
uniprot id: A0A7D4P4T3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LplA family.
messages: Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.
messages: Cytoplasm
messages: In the transfer reaction, the free carboxyl group of lipoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.
messages: Monomer.

349967:HRD69 RS15195
gene id: 349967:HRD69_RS15195
uniprot id: A0A7D4SX85
names: Subcellular Location Annotation
messages: Cell outer membrane

349967:HRD69 RS15065
gene id: 349967:HRD69_RS15065
uniprot id: A0A7D4PGL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS17355
gene id: 349967:HRD69_RS17355
uniprot id: A0A7D4PCN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

349967:HRD69 RS17925
gene id: 349967:HRD69_RS17925
uniprot id: A0A7D4P7A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MukF family.
messages: Interacts, and probably forms a ternary complex, with MukE and MukB via its C-terminal region. The complex formation is stimulated by calcium or magnesium. It is required for an interaction between MukE and MukB.
messages: Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity.
messages: nucleoid

349967:HRD69 RS09300
gene id: 349967:HRD69_RS09300
uniprot id: A0A7D4SVP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

349967:HRD69 RS14805
gene id: 349967:HRD69_RS14805
uniprot id: A0A7D4PT47
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

349967:HRD69 RS04305
gene id: 349967:HRD69_RS04305
uniprot id: A0A7D4PQR8
names: Function
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.
messages: Catalyzes the synthesis of dTDP-4-amino-4,6-dideoxy-D-galactose (dTDP-Fuc4N) from dTDP-4-keto-6-deoxy-D-glucose (dTDP-D-Glc4O) and L-glutamate.

349967:HRD69 RS20460
gene id: 349967:HRD69_RS20460
uniprot id: A0A7D4U5E2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family. RcnA subfamily.
messages: Cell membrane
messages: Efflux system for nickel and cobalt.
messages: Membrane

349967:HRD69 RS16315
gene id: 349967:HRD69_RS16315
uniprot id: A0A7D4TPN6
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

349967:HRD69 RS12970
gene id: 349967:HRD69_RS12970
uniprot id: A0A7D4U1H3
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

349967:HRD69 RS08890
gene id: 349967:HRD69_RS08890
uniprot id: A0A7D4U2I9
names: Function
names: Similarity
messages: Belongs to the Ap4A hydrolase family.
messages: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.

349967:HRD69 RS18430
gene id: 349967:HRD69_RS18430
uniprot id: A0A7D4U501
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS20420
gene id: 349967:HRD69_RS20420
uniprot id: A0A7D4SY42
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

349967:HRD69 RS17345
gene id: 349967:HRD69_RS17345
uniprot id: A0A7D4U2J4
names: Similarity
messages: Belongs to the fabD family.

349967:HRD69 RS16570
gene id: 349967:HRD69_RS16570
uniprot id: A0A7D4P3Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 9 family.
messages: Periplasm

349967:HRD69 RS20300
gene id: 349967:HRD69_RS20300
uniprot id: A0A7D4TQX4
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

349967:HRD69 RS15605
gene id: 349967:HRD69_RS15605
uniprot id: A0A7D4P6T9
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS13640
gene id: 349967:HRD69_RS13640
uniprot id: A0A7D4TZW6
names: Function
names: Similarity
messages: Belongs to the FlgM family.
messages: Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA.

349967:HRD69 RS12725
gene id: 349967:HRD69_RS12725
uniprot id: A0A7D4T2R7
names: Function
names: Similarity
messages: Belongs to the esterase D family.
messages: Serine hydrolase involved in the detoxification of formaldehyde.

349967:HRD69 RS10940
gene id: 349967:HRD69_RS10940
uniprot id: A0A7D4TGW1
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS07465
gene id: 349967:HRD69_RS07465
uniprot id: A0A7D4P9U8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AcsB/BcsB family.
messages: Binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP).
messages: Cell inner membrane
messages: Tightly associated with the cellulose synthase catalytic subunit.

349967:HRD69 RS00115
gene id: 349967:HRD69_RS00115
uniprot id: A0A7D4TVW3
names: Similarity
messages: Belongs to the ABC transporter superfamily.

349967:HRD69 RS18195
gene id: 349967:HRD69_RS18195
uniprot id: A0A7D4PUE0
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.
messages: Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.

349967:HRD69 RS04910
gene id: 349967:HRD69_RS04910
uniprot id: A0A7D4T176
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

349967:HRD69 RS10600
gene id: 349967:HRD69_RS10600
uniprot id: A0A7D4SVY1
names: Similarity
messages: Belongs to the nucleoside-specific channel-forming outer membrane porin (Tsx) (TC 1.B.10) family.

349967:HRD69 RS09120
gene id: 349967:HRD69_RS09120
uniprot id: A0A7D4P268
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

349967:HRD69 RS00575
gene id: 349967:HRD69_RS00575
uniprot id: A0A7D4TKI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

349967:HRD69 RS06775
gene id: 349967:HRD69_RS06775
uniprot id: A0A7D4P9Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. KefB subfamily.
messages: Cell inner membrane
messages: Interacts with the regulatory subunit KefG.
messages: Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport.

349967:HRD69 RS17800
gene id: 349967:HRD69_RS17800
uniprot id: A0A7D4P479
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MatP family.
messages: Cytoplasm
messages: Homodimer.
messages: Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain.

349967:HRD69 RS13885
gene id: 349967:HRD69_RS13885
uniprot id: A0A7D4P6G9
names: Cofactor
names: Similarity
messages: Belongs to the WrbA family.
messages: Binds 1 FMN per monomer.

349967:HRD69 RS18835
gene id: 349967:HRD69_RS18835
uniprot id: A0A7D4SXV2
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

349967:HRD69 RS02045
gene id: 349967:HRD69_RS02045
uniprot id: A0A7D4TIB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Flagellar protein that affects chemotactic events.
messages: Membrane

349967:HRD69 RS12895
gene id: 349967:HRD69_RS12895
uniprot id: A0A7D4P667
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

349967:HRD69 RS04105
gene id: 349967:HRD69_RS04105
uniprot id: A0A7D4TLE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcrB family.
messages: Cell membrane
messages: Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis. Essential for lipoprotein maturation under conditions where membrane fluidity may be altered.

349967:HRD69 RS12965
gene id: 349967:HRD69_RS12965
uniprot id: A0A7D4U3L1
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: In the N-terminal section; belongs to the histidinol-phosphatase family.

349967:HRD69 RS04330
gene id: 349967:HRD69_RS04330
uniprot id: A0A7D4T139
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.
messages: Catalyzes the reversible epimerization at C-2 of UDP-N-acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues.
messages: Cytoplasm
messages: Homodimer.

349967:HRD69 RS19325
gene id: 349967:HRD69_RS19325
uniprot id: A0A7D4SXV0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Nudix hydrolase family. NudK subfamily.
messages: Homodimer.
messages: Nucleoside diphosphate sugar hydrolase that hydrolyzes GDP-mannose as its preferred substrate, yielding GMP and mannose-1-phosphate.

349967:HRD69 RS13645
gene id: 349967:HRD69_RS13645
uniprot id: A0A7D4U3R5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FlgA family.
messages: Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly.
messages: Periplasm

349967:HRD69 RS06210
gene id: 349967:HRD69_RS06210
uniprot id: A0A7D4TJD4
names: Similarity
messages: Belongs to the peptidase M10B family.

349967:HRD69 RS01605
gene id: 349967:HRD69_RS01605
uniprot id: A0A7D4TYP4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
messages: Cell membrane
messages: Heterodimer of a large and a small subunit.

349967:HRD69 RS01460
gene id: 349967:HRD69_RS01460
uniprot id: A0A7D4SUW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbA subfamily.
messages: Periplasm

349967:HRD69 RS14955
gene id: 349967:HRD69_RS14955
uniprot id: A0A7D4TPB9
names: Similarity
messages: Belongs to the peptidase S49 family.

349967:HRD69 RS18760
gene id: 349967:HRD69_RS18760
uniprot id: A0A7D4TMP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmE/CycJ family.
messages: Cell membrane
messages: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.

349967:HRD69 RS20255
gene id: 349967:HRD69_RS20255
uniprot id: A0A7D4PUJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

349967:HRD69 RS00505
gene id: 349967:HRD69_RS00505
uniprot id: A0A7D4P628
names: Function
messages: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division.

349967:HRD69 RS19250
gene id: 349967:HRD69_RS19250
uniprot id: A0A7D4U2Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family.
messages: Catalyzes the proton-dependent transport of sialic acid.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS05680
gene id: 349967:HRD69_RS05680
uniprot id: A0A7D4TJ86
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS18270
gene id: 349967:HRD69_RS18270
uniprot id: A0A7D4PHI8
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

349967:HRD69 RS09240
gene id: 349967:HRD69_RS09240
uniprot id: A0A7D4P7X4
names: Cofactor
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.

349967:HRD69 RS10230
gene id: 349967:HRD69_RS10230
uniprot id: A0A7D4PAP3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds 1 Fe(2+) cation per monomer.
messages: Binds 1 nickel ion per monomer.
messages: Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
messages: Monomer.

349967:HRD69 RS01965
gene id: 349967:HRD69_RS01965
uniprot id: A0A7D4P6C7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

349967:HRD69 RS10930
gene id: 349967:HRD69_RS10930
uniprot id: A0A7D4TN83
names: Similarity
messages: Belongs to the phosphohexose mutase family.

349967:HRD69 RS15985
gene id: 349967:HRD69_RS15985
uniprot id: A0A7D4T3A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS06205
gene id: 349967:HRD69_RS06205
uniprot id: A0A7D4TFP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmJ family.
messages: Cytoplasm
messages: Specifically methylates the guanosine in position 1516 of 16S rRNA.

349967:HRD69 RS06825
gene id: 349967:HRD69_RS06825
uniprot id: A0A7D4SVV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

349967:HRD69 RS07735
gene id: 349967:HRD69_RS07735
uniprot id: A0A7D4PRI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

349967:HRD69 RS17520
gene id: 349967:HRD69_RS17520
uniprot id: A0A7D4TQ78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

349967:HRD69 RS06965
gene id: 349967:HRD69_RS06965
uniprot id: A0A7D4U200
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

349967:HRD69 RS13585
gene id: 349967:HRD69_RS13585
uniprot id: A0A7D4PSW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS12315
gene id: 349967:HRD69_RS12315
uniprot id: A0A7D4TZE8
names: Similarity
messages: Belongs to the Nudix hydrolase family.

349967:HRD69 RS13195
gene id: 349967:HRD69_RS13195
uniprot id: A0A7D4PBD8
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

349967:HRD69 RS05895
gene id: 349967:HRD69_RS05895
uniprot id: A0A7D4TZW5
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS11725
gene id: 349967:HRD69_RS11725
uniprot id: A0A7D4PSK6
names: Similarity
messages: Belongs to the aldose epimerase family.

349967:HRD69 RS11340
gene id: 349967:HRD69_RS11340
uniprot id: A0A7D4PFT3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

349967:HRD69 RS16555
gene id: 349967:HRD69_RS16555
uniprot id: A0A7D4U0T4
names: Similarity
messages: Belongs to the pyruvate kinase family.

349967:HRD69 RS08835
gene id: 349967:HRD69_RS08835
uniprot id: A0A7D4PRY1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

349967:HRD69 RS04870
gene id: 349967:HRD69_RS04870
uniprot id: A0A7D4P2J3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.

349967:HRD69 RS18445
gene id: 349967:HRD69_RS18445
uniprot id: A0A7D4PCX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS18205
gene id: 349967:HRD69_RS18205
uniprot id: A0A7D4TMF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

349967:HRD69 RS18910
gene id: 349967:HRD69_RS18910
uniprot id: C4SGN8
names: Function
names: Subunit
messages: Forms a 1:1 complex with cognate toxin CdiA.
messages: Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion. Protects cells against the tRNA endonuclease activity of cognate toxin CdiA-43969 but not other non-cognate toxins, inhibits the tRNase activity of the isolated CT fragment of CdiA-43969.

349967:HRD69 RS07330
gene id: 349967:HRD69_RS07330
uniprot id: A0A7D4TY63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial secretin family. T3SS SctC subfamily.
messages: Cell outer membrane
messages: Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. Forms a ring-shaped multimeric structure with an apparent central pore in the outer membrane.
messages: Membrane
messages: The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle. This subunit is part of the base, which anchors the injectisome in the bacterial cell envelope. Forms a stable homooligomeric complex.

349967:HRD69 RS16560
gene id: 349967:HRD69_RS16560
uniprot id: A0A7D4U4F7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LpxL/LpxM/LpxP family. LpxM subfamily.
messages: Catalyzes the transfer of an acyl chain from an acyl-[acyl-carrier-protein] (ACP) to a Kdo(2)-(acyl)-lipid IV(A) to form a Kdo(2)-lipid A.
messages: Cell inner membrane

349967:HRD69 RS15335
gene id: 349967:HRD69_RS15335
uniprot id: A0A7D4TI65
names: Similarity
messages: Belongs to the aldolase class II family. AraD/FucA subfamily.

349967:HRD69 RS16200
gene id: 349967:HRD69_RS16200
uniprot id: A0A7D4T3B9
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS07195
gene id: 349967:HRD69_RS07195
uniprot id: A0A7D4T659
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP J family.
messages: Cell inner membrane
messages: Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Part of the pseudopilus tip complex that is critical for the recognition and binding of secretion substrates.
messages: Membrane

349967:HRD69 RS05115
gene id: 349967:HRD69_RS05115
uniprot id: A0A7D4PKT1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm

349967:HRD69 RS07905
gene id: 349967:HRD69_RS07905
uniprot id: A0A7D4U283
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

349967:HRD69 RS00215
gene id: 349967:HRD69_RS00215
uniprot id: A0A7D4STY0
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS09425
gene id: 349967:HRD69_RS09425
uniprot id: A0A7D4TMX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

349967:HRD69 RS17940
gene id: 349967:HRD69_RS17940
uniprot id: A0A7D4PU28
names: Similarity
messages: Belongs to the fructosamine kinase family.

349967:HRD69 RS14750
gene id: 349967:HRD69_RS14750
uniprot id: A0A7D4U408
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS12485
gene id: 349967:HRD69_RS12485
uniprot id: A0A7D4SWS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

349967:HRD69 RS01830
gene id: 349967:HRD69_RS01830
uniprot id: A0A7D4TYR1
names: Subunit
messages: Monomer.

349967:HRD69 RS08410
gene id: 349967:HRD69_RS08410
uniprot id: A0A7D4PLG2
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS20045
gene id: 349967:HRD69_RS20045
uniprot id: A0A7D4PUI1
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
messages: Binds 2 divalent metal cations per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS10415
gene id: 349967:HRD69_RS10415
uniprot id: A0A7D4TYX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

349967:HRD69 RS02365
gene id: 349967:HRD69_RS02365
uniprot id: A0A7D4SV17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS12830
gene id: 349967:HRD69_RS12830
uniprot id: A0A7D4T2S4
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS00375
gene id: 349967:HRD69_RS00375
uniprot id: A0A7D4TW18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

349967:HRD69 RS05935
gene id: 349967:HRD69_RS05935
uniprot id: A0A7D4PPL5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the xylose isomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

349967:HRD69 RS01950
gene id: 349967:HRD69_RS01950
uniprot id: A0A7D4P0M2
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Comprises two domains: an N-terminal domain containing the nucleotidyltransferase activity and a C-terminal HD domain associated with both phosphodiesterase and phosphatase activities.
messages: Magnesium is required for nucleotidyltransferase activity.
messages: Monomer. Can also form homodimers and oligomers.
messages: Nickel for phosphatase activity.

349967:HRD69 RS18380
gene id: 349967:HRD69_RS18380
uniprot id: A0A7D4PNP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
messages: Periplasm

349967:HRD69 RS15945
gene id: 349967:HRD69_RS15945
uniprot id: A0A7D4P4Q6
names: Similarity
messages: Belongs to the ner transcriptional regulatory family.

349967:HRD69 RS18400
gene id: 349967:HRD69_RS18400
uniprot id: A0A7D4T3R4
names: Function
names: Similarity
messages: Belongs to the mannonate dehydratase family.
messages: Catalyzes the dehydration of D-mannonate.

349967:HRD69 RS07625
gene id: 349967:HRD69_RS07625
uniprot id: A0A7D4PF23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

349967:HRD69 RS14020
gene id: 349967:HRD69_RS14020
uniprot id: A0A7D4PSZ8
names: Similarity
messages: Belongs to the myoviridae tail sheath protein family.

349967:HRD69 RS17155
gene id: 349967:HRD69_RS17155
uniprot id: A0A7D4P744
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HflD family.
messages: Cell membrane
messages: Cytoplasm

349967:HRD69 RS10545
gene id: 349967:HRD69_RS10545
uniprot id: A0A7D4U3I9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

349967:HRD69 RS11430
gene id: 349967:HRD69_RS11430
uniprot id: A0A7D4U162
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

349967:HRD69 RS18065
gene id: 349967:HRD69_RS18065
uniprot id: A0A7D4P5W5
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS05385
gene id: 349967:HRD69_RS05385
uniprot id: A0A7D4U1J6
names: Similarity
names: Subunit
messages: Belongs to the ViaA family.
messages: Possible formation of a ternary complex RavA-ViaA-CadA.

349967:HRD69 RS19530
gene id: 349967:HRD69_RS19530
uniprot id: A0A7D4PP18
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

349967:HRD69 RS12080
gene id: 349967:HRD69_RS12080
uniprot id: A0A7D4T2N7
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the RcsB family.
messages: Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions.
messages: Interacts with RcsD.
messages: Phosphorylated and activated by RcsD.

349967:HRD69 RS08520
gene id: 349967:HRD69_RS08520
uniprot id: A0A7D4SW60
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS10705
gene id: 349967:HRD69_RS10705
uniprot id: A0A7D4SVY9
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

349967:HRD69 RS01570
gene id: 349967:HRD69_RS01570
uniprot id: A0A7D4T0L8
names: Similarity
messages: Belongs to the HypE family.

349967:HRD69 RS06495
gene id: 349967:HRD69_RS06495
uniprot id: A0A7D4T1G5
names: Function
names: Similarity
messages: Belongs to the FeoC family.
messages: May function as a transcriptional regulator that controls feoABC expression.

349967:HRD69 RS00105
gene id: 349967:HRD69_RS00105
uniprot id: A0A7D4TEE8
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

349967:HRD69 RS04575
gene id: 349967:HRD69_RS04575
uniprot id: A0A7D4TFC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).

349967:HRD69 RS03775
gene id: 349967:HRD69_RS03775
uniprot id: A0A7D4TF74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic pantothenate kinase family.
messages: Cytoplasm

349967:HRD69 RS18185
gene id: 349967:HRD69_RS18185
uniprot id: A0A7D4TQD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS10355
gene id: 349967:HRD69_RS10355
uniprot id: A0A7D4TNP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

349967:HRD69 RS03530
gene id: 349967:HRD69_RS03530
uniprot id: A0A7D4P8R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

349967:HRD69 RS15360
gene id: 349967:HRD69_RS15360
uniprot id: A0A7D4P3Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

349967:HRD69 RS19390
gene id: 349967:HRD69_RS19390
uniprot id: A0A7D4PA76
names: Similarity
messages: Belongs to the ArsC family.

349967:HRD69 RS13280
gene id: 349967:HRD69_RS13280
uniprot id: A0A7D4TZP0
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

349967:HRD69 RS00345
gene id: 349967:HRD69_RS00345
uniprot id: A0A7D4STY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxA subfamily.
messages: Cytoplasm
messages: Homotrimer.
messages: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

349967:HRD69 RS10225
gene id: 349967:HRD69_RS10225
uniprot id: A0A7D4P2D9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Monomer.

349967:HRD69 RS13525
gene id: 349967:HRD69_RS13525
uniprot id: A0A7D4TLA4
names: Subcellular Location Annotation
messages: Cytoplasm

349967:HRD69 RS09100
gene id: 349967:HRD69_RS09100
uniprot id: A0A7D4TK82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

349967:HRD69 RS07850
gene id: 349967:HRD69_RS07850
uniprot id: A0A7D4PF37
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

349967:HRD69 RS06605
gene id: 349967:HRD69_RS06605
uniprot id: A0A7D4T1H2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DamX family.
messages: Cell inner membrane
messages: Non-essential cell division protein.
messages: The SPOR domain binds septal peptidoglycans and is required to target DamX to the septal ring.

349967:HRD69 RS08875
gene id: 349967:HRD69_RS08875
uniprot id: A0A7D4TGF4
names: Similarity
messages: Belongs to the ThrE exporter (TC 2.A.79) family.

349967:HRD69 RS14630
gene id: 349967:HRD69_RS14630
uniprot id: A0A7D4U053
names: Similarity
messages: Belongs to the peptidase S41A family.

349967:HRD69 RS11290
gene id: 349967:HRD69_RS11290
uniprot id: A0A7D4U373
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptE lipoprotein family.
messages: Cell outer membrane
messages: Component of the lipopolysaccharide transport and assembly complex. Interacts with LptD.
messages: Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.

349967:HRD69 RS10685
gene id: 349967:HRD69_RS10685
uniprot id: A0A7D4PFP2
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS12770
gene id: 349967:HRD69_RS12770
uniprot id: A0A7D4PB98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).

349967:HRD69 RS20455
gene id: 349967:HRD69_RS20455
uniprot id: A0A7D4U2A2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HdeB family.
messages: Periplasm
messages: Required for optimal acid stress protection, which is important for survival of enteric bacteria in the acidic environment of the host stomach. Exhibits a chaperone-like activity at acidic pH by preventing the aggregation of many different periplasmic proteins.

349967:HRD69 RS02125
gene id: 349967:HRD69_RS02125
uniprot id: A0A7D4PK16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

349967:HRD69 RS16755
gene id: 349967:HRD69_RS16755
uniprot id: A0A7D4T3F6
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

349967:HRD69 RS00910
gene id: 349967:HRD69_RS00910
uniprot id: A0A7D4TEL8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

349967:HRD69 RS11930
gene id: 349967:HRD69_RS11930
uniprot id: A0A7D4P413
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

349967:HRD69 RS11525
gene id: 349967:HRD69_RS11525
uniprot id: A0A7D4T709
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase class-II family.

349967:HRD69 RS15635
gene id: 349967:HRD69_RS15635
uniprot id: A0A7D4PN11
names: Similarity
messages: Belongs to the UPF0482 family.

349967:HRD69 RS12275
gene id: 349967:HRD69_RS12275
uniprot id: A0A7D4SWR2
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS03725
gene id: 349967:HRD69_RS03725
uniprot id: A0A7D4SV90
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

349967:HRD69 RS08860
gene id: 349967:HRD69_RS08860
uniprot id: A0A7D4T201
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

349967:HRD69 RS08885
gene id: 349967:HRD69_RS08885
uniprot id: A0A7D4TYJ5
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

349967:HRD69 RS01540
gene id: 349967:HRD69_RS01540
uniprot id: A0A7D4PNC3
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS15135
gene id: 349967:HRD69_RS15135
uniprot id: A0A7D4P3P0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YciB family.
messages: Cell inner membrane
messages: Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.

349967:HRD69 RS03200
gene id: 349967:HRD69_RS03200
uniprot id: A0A7D4TZ55
names: Similarity
messages: Belongs to the peptidase U62 family.

349967:HRD69 RS00570
gene id: 349967:HRD69_RS00570
uniprot id: A0A7D4T0F8
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS00465
gene id: 349967:HRD69_RS00465
uniprot id: A0A7D4TEI1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Xni family.
messages: Binds 1 K(+) per subunit. The potassium ion strongly increases the affinity for DNA.
messages: Binds 2 Mg(2+) per subunit. Only one magnesium ion has a direct interaction with the protein, the other interactions are indirect.
messages: Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.

349967:HRD69 RS09470
gene id: 349967:HRD69_RS09470
uniprot id: A0A7D4U2F7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dGTPase family. Type 1 subfamily.
messages: Homotetramer.
messages: dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs.

349967:HRD69 RS19550
gene id: 349967:HRD69_RS19550
uniprot id: A0A7D4T3Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

349967:HRD69 RS04550
gene id: 349967:HRD69_RS04550
uniprot id: A0A7D4SVF7
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

349967:HRD69 RS03740
gene id: 349967:HRD69_RS03740
uniprot id: A0A7D4TLC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

349967:HRD69 RS07930
gene id: 349967:HRD69_RS07930
uniprot id: A0A7D4P7L1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

349967:HRD69 RS19190
gene id: 349967:HRD69_RS19190
uniprot id: A0A7D4PUB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

349967:HRD69 RS06790
gene id: 349967:HRD69_RS06790
uniprot id: A0A7D4P785
names: Similarity
messages: Belongs to the SlyX family.

349967:HRD69 RS02335
gene id: 349967:HRD69_RS02335
uniprot id: A0A7D4P232
names: Similarity
messages: Belongs to the UxaA family.

349967:HRD69 RS17840
gene id: 349967:HRD69_RS17840
uniprot id: A0A7D4PHD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PqiA family.
messages: Component of a transport pathway that contributes to membrane integrity.
messages: Membrane

349967:HRD69 RS13180
gene id: 349967:HRD69_RS13180
uniprot id: A0A7D4U3N4
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

349967:HRD69 RS19510
gene id: 349967:HRD69_RS19510
uniprot id: A0A7D4P5E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

349967:HRD69 RS04685
gene id: 349967:HRD69_RS04685
uniprot id: A0A7D4PEE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

349967:HRD69 RS06410
gene id: 349967:HRD69_RS06410
uniprot id: A0A7D4TFR4
names: Function
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.
messages: Removes maltotriose and maltotetraose chains that are attached by 1,6-alpha-linkage to the limit dextrin main chain, generating a debranched limit dextrin.

349967:HRD69 RS02790
gene id: 349967:HRD69_RS02790
uniprot id: A0A7D4P9C3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

349967:HRD69 RS03630
gene id: 349967:HRD69_RS03630
uniprot id: A0A7D4T105
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

349967:HRD69 RS13820
gene id: 349967:HRD69_RS13820
uniprot id: A0A7D4T2Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sigma-70 factor family. FliA subfamily.
messages: Cytoplasm
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes.

349967:HRD69 RS03255
gene id: 349967:HRD69_RS03255
uniprot id: A0A7D4SV68
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MsrQ family.
messages: Binds 1 FMN per subunit.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Cell membrane
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Membrane
messages: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.

349967:HRD69 RS08180
gene id: 349967:HRD69_RS08180
uniprot id: A0A7D4PLE2
names: Function
names: Similarity
messages: Belongs to the PhnJ family.
messages: Catalyzes the breakage of the C-P bond in alpha-D-ribose 1-methylphosphonate 5-phosphate (PRPn) forming alpha-D-ribose.

349967:HRD69 RS09570
gene id: 349967:HRD69_RS09570
uniprot id: A0A7D4P2A7
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

349967:HRD69 RS17350
gene id: 349967:HRD69_RS17350
uniprot id: A0A7D4P453
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

349967:HRD69 RS01935
gene id: 349967:HRD69_RS01935
uniprot id: A0A7D4U3C1
names: Function
names: Similarity
messages: Belongs to the GlnE family.
messages: Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.

349967:HRD69 RS05830
gene id: 349967:HRD69_RS05830
uniprot id: A0A7D4PPK0
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

349967:HRD69 RS13430
gene id: 349967:HRD69_RS13430
uniprot id: A0A7D4P8S7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CitD family.
messages: Covalent carrier of the coenzyme of citrate lyase.
messages: Cytoplasm
messages: Oligomer with a subunit composition of (alpha,beta,gamma)6.

349967:HRD69 RS12230
gene id: 349967:HRD69_RS12230
uniprot id: A0A7D4PB48
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily.
messages: Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS12960
gene id: 349967:HRD69_RS12960
uniprot id: A0A7D4TZL3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

349967:HRD69 RS10495
gene id: 349967:HRD69_RS10495
uniprot id: A0A7D4SVX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

349967:HRD69 RS02510
gene id: 349967:HRD69_RS02510
uniprot id: A0A7D4TL25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the periplasmic pilus chaperone family.
messages: Periplasm

349967:HRD69 RS18365
gene id: 349967:HRD69_RS18365
uniprot id: A0A7D4PTJ4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport.

349967:HRD69 RS04845
gene id: 349967:HRD69_RS04845
uniprot id: A0A7D4P161
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

349967:HRD69 RS12140
gene id: 349967:HRD69_RS12140
uniprot id: A0A7D4P8J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

349967:HRD69 RS07555
gene id: 349967:HRD69_RS07555
uniprot id: A0A7D4T677
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible retro-aldol cleavage of both 5-keto-4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde.
messages: Homohexamer; trimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS00415
gene id: 349967:HRD69_RS00415
uniprot id: A0A7D4P1S0
names: Activity Regulation
names: Domain
names: Function
names: Similarity
messages: Belongs to the GlnD family.
messages: Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.
messages: Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.
messages: Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

349967:HRD69 RS14330
gene id: 349967:HRD69_RS14330
uniprot id: A0A7D4P8Z7
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

349967:HRD69 RS08635
gene id: 349967:HRD69_RS08635
uniprot id: A0A7D4SW64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
messages: Homohexamer; trimer of homodimers.

349967:HRD69 RS06860
gene id: 349967:HRD69_RS06860
uniprot id: A0A7D4TY27
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

349967:HRD69 RS18390
gene id: 349967:HRD69_RS18390
uniprot id: A0A7D4PIB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily.
messages: Cell inner membrane
messages: Involved in transporting aromatic amino acids across the cytoplasmic membrane.
messages: Membrane

349967:HRD69 RS19925
gene id: 349967:HRD69_RS19925
uniprot id: A0A7D4PTY9
names: Function
names: Similarity
messages: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
messages: Protects the bacterial cell from host peptidases.

349967:HRD69 RS05815
gene id: 349967:HRD69_RS05815
uniprot id: A0A7D4P724
names: Similarity
messages: Belongs to the VapB family.

349967:HRD69 RS12160
gene id: 349967:HRD69_RS12160
uniprot id: A0A7D4PSN5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

349967:HRD69 RS13960
gene id: 349967:HRD69_RS13960
uniprot id: A0A7D4U3U3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

349967:HRD69 RS13865
gene id: 349967:HRD69_RS13865
uniprot id: A0A7D4P3D8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Catalyzes the sodium-dependent uptake of extracellular L-proline.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS15815
gene id: 349967:HRD69_RS15815
uniprot id: A0A7D4P3T3
names: Cofactor
names: Similarity
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.

349967:HRD69 RS06600
gene id: 349967:HRD69_RS06600
uniprot id: A0A7D4SV51
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm

349967:HRD69 RS04790
gene id: 349967:HRD69_RS04790
uniprot id: A0A7D4PKQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

349967:HRD69 RS16875
gene id: 349967:HRD69_RS16875
uniprot id: A0A7D4P5V6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

349967:HRD69 RS00830
gene id: 349967:HRD69_RS00830
uniprot id: A0A7D4P7Z6
names: Similarity
messages: Belongs to the UbiH/COQ6 family.

349967:HRD69 RS16115
gene id: 349967:HRD69_RS16115
uniprot id: A0A7D4TID3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. DtpA subfamily.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-dependent permease that transports di- and tripeptides.

349967:HRD69 RS03335
gene id: 349967:HRD69_RS03335
uniprot id: A0A7D4P299
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
messages: Cell inner membrane
messages: Membrane
messages: Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).

349967:HRD69 RS03285
gene id: 349967:HRD69_RS03285
uniprot id: A0A7D4TIL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

349967:HRD69 RS10560
gene id: 349967:HRD69_RS10560
uniprot id: A0A7D4P892
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

349967:HRD69 RS16440
gene id: 349967:HRD69_RS16440
uniprot id: A0A7D4U0S4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: Multifunctional regulator of fatty acid metabolism.

349967:HRD69 RS07025
gene id: 349967:HRD69_RS07025
uniprot id: A0A7D4SVX5
names: Similarity
messages: Belongs to the DprA/Smf family.

349967:HRD69 RS00890
gene id: 349967:HRD69_RS00890
uniprot id: A0A7D4SU16
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

349967:HRD69 RS06905
gene id: 349967:HRD69_RS06905
uniprot id: A0A7D4PQ05
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

349967:HRD69 RS01525
gene id: 349967:HRD69_RS01525
uniprot id: A0A7D4P696
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS04190
gene id: 349967:HRD69_RS04190
uniprot id: A0A7D4PKL4
names: Similarity
messages: Belongs to the UPF0261 family.

349967:HRD69 RS06620
gene id: 349967:HRD69_RS06620
uniprot id: A0A7D4TFT1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
messages: Monomer.
messages: Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.

349967:HRD69 RS08755
gene id: 349967:HRD69_RS08755
uniprot id: A0A7D4TMR5
names: Similarity
messages: Belongs to the threonine synthase family.

349967:HRD69 RS12585
gene id: 349967:HRD69_RS12585
uniprot id: A0A7D4PSQ3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the helicase family. DinG subfamily. Type 1 sub-subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA-dependent ATPase and 5'-3' DNA helicase.

349967:HRD69 RS04095
gene id: 349967:HRD69_RS04095
uniprot id: A0A7D4SUN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sulfur carrier protein TusA family.
messages: Cytoplasm
messages: Interacts with IscS.
messages: Sulfur carrier protein involved in sulfur trafficking in the cell. Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA. Interacts with IscS and stimulates its cysteine desulfurase activity. Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation. Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin.

349967:HRD69 RS04530
gene id: 349967:HRD69_RS04530
uniprot id: A0A7D4PP53
names: Function
names: Similarity
names: Subunit
messages: Belongs to the serine/threonine dehydratase family.
messages: Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
messages: Homotetramer.

349967:HRD69 RS20160
gene id: 349967:HRD69_RS20160
uniprot id: A0A7D4PP69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

349967:HRD69 RS14965
gene id: 349967:HRD69_RS14965
uniprot id: A0A7D4T7P4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the selenophosphate synthase 1 family. Class I subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Homodimer.
messages: Synthesizes selenophosphate from selenide and ATP.

349967:HRD69 RS17320
gene id: 349967:HRD69_RS17320
uniprot id: A0A7D4T859
names: Function
names: Similarity
messages: Belongs to the transglycosylase MltG family.
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

349967:HRD69 RS12055
gene id: 349967:HRD69_RS12055
uniprot id: A0A7D4PSM9
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

349967:HRD69 RS10335
gene id: 349967:HRD69_RS10335
uniprot id: A0A7D4PBP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
messages: Cell membrane
messages: Homotetramer.
messages: Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine.

349967:HRD69 RS00205
gene id: 349967:HRD69_RS00205
uniprot id: A0A7D4PJI1
names: Subunit
messages: Monomer.

349967:HRD69 RS15510
gene id: 349967:HRD69_RS15510
uniprot id: A0A7D4PT98
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the arabinose isomerase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of L-arabinose to L-ribulose.
messages: Homohexamer.

349967:HRD69 RS11495
gene id: 349967:HRD69_RS11495
uniprot id: A0A7D4SYC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

349967:HRD69 RS02200
gene id: 349967:HRD69_RS02200
uniprot id: A0A7D4PUL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgH family.
messages: Cell outer membrane
messages: Membrane
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

349967:HRD69 RS12310
gene id: 349967:HRD69_RS12310
uniprot id: A0A7D4TKW2
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

349967:HRD69 RS19280
gene id: 349967:HRD69_RS19280
uniprot id: A0A7D4PEC7
names: Similarity
messages: Belongs to the DapA family.

349967:HRD69 RS06470
gene id: 349967:HRD69_RS06470
uniprot id: A0A7D4PR82
names: Similarity
messages: Belongs to the disproportionating enzyme family.

349967:HRD69 RS17315
gene id: 349967:HRD69_RS17315
uniprot id: A0A7D4TQ62
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

349967:HRD69 RS11845
gene id: 349967:HRD69_RS11845
uniprot id: A0A7D4SWN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

349967:HRD69 RS12850
gene id: 349967:HRD69_RS12850
uniprot id: A0A7D4THE6
names: Similarity
messages: Belongs to the HupF/HypC family.

349967:HRD69 RS18085
gene id: 349967:HRD69_RS18085
uniprot id: A0A7D4TQD2
names: Similarity
messages: Belongs to the ClpA/ClpB family.

349967:HRD69 RS05595
gene id: 349967:HRD69_RS05595
uniprot id: A0A7D4TZT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

349967:HRD69 RS01755
gene id: 349967:HRD69_RS01755
uniprot id: A0A7D4P1Y8
names: Similarity
messages: Belongs to the bacterial secretin family.

349967:HRD69 RS06320
gene id: 349967:HRD69_RS06320
uniprot id: A0A7D4TXV2
names: Similarity
messages: Belongs to the TPP enzyme family.

349967:HRD69 RS13155
gene id: 349967:HRD69_RS13155
uniprot id: A0A7D4TNT6
names: Similarity
messages: Belongs to the diol/glycerol dehydratase large subunit family.

349967:HRD69 RS02955
gene id: 349967:HRD69_RS02955
uniprot id: A0A7D4TL60
names: Function
names: Similarity
messages: Belongs to the sigma-54 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

349967:HRD69 RS05420
gene id: 349967:HRD69_RS05420
uniprot id: A0A7D4P2N2
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS11040
gene id: 349967:HRD69_RS11040
uniprot id: A0A7D4T6Y1
names: Subcellular Location Annotation
messages: Membrane

349967:HRD69 RS10285
gene id: 349967:HRD69_RS10285
uniprot id: A0A7D4T297
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NqrB/RnfD family.
messages: Cell membrane
messages: Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF.
messages: NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.

349967:HRD69 RS13535
gene id: 349967:HRD69_RS13535
uniprot id: A0A7D4U3Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS11270
gene id: 349967:HRD69_RS11270
uniprot id: A0A7D4T6Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

349967:HRD69 RS12760
gene id: 349967:HRD69_RS12760
uniprot id: A0A7D4U1F8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 2 family.
messages: Periplasm
messages: The ABC transporter complex is composed of one ATP-binding protein (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB).

349967:HRD69 RS09640
gene id: 349967:HRD69_RS09640
uniprot id: A0A7D4TMZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

349967:HRD69 RS10505
gene id: 349967:HRD69_RS10505
uniprot id: A0A7D4TN57
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

349967:HRD69 RS12625
gene id: 349967:HRD69_RS12625
uniprot id: A0A7D4T794
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

349967:HRD69 RS00610
gene id: 349967:HRD69_RS00610
uniprot id: A0A7D4P0C5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. LplT (TC 2.A.1.42) family.
messages: Catalyzes the facilitated diffusion of 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) into the cell.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS04995
gene id: 349967:HRD69_RS04995
uniprot id: A0A7D4PKS3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

349967:HRD69 RS13800
gene id: 349967:HRD69_RS13800
uniprot id: A0A7D4PGB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

349967:HRD69 RS20440
gene id: 349967:HRD69_RS20440
uniprot id: A0A7D4T8U9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

349967:HRD69 RS11560
gene id: 349967:HRD69_RS11560
uniprot id: A0A7D4PAZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Homotetramer.
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

349967:HRD69 RS18770
gene id: 349967:HRD69_RS18770
uniprot id: A0A7D4U533
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

349967:HRD69 RS13735
gene id: 349967:HRD69_RS13735
uniprot id: A0A7D4TLB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Cell inner membrane
messages: FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

349967:HRD69 RS10660
gene id: 349967:HRD69_RS10660
uniprot id: A0A7D4P8A2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

349967:HRD69 RS09900
gene id: 349967:HRD69_RS09900
uniprot id: A0A7D4TGN0
names: Similarity
messages: Belongs to the SorC transcriptional regulatory family.

349967:HRD69 RS18425
gene id: 349967:HRD69_RS18425
uniprot id: A0A7D4U1N6
names: Similarity
messages: Belongs to the peptidase C40 family.

349967:HRD69 RS17960
gene id: 349967:HRD69_RS17960
uniprot id: A0A7D4SXH7
names: Similarity
messages: Belongs to the 2-oxoadipate dioxygenase/decarboxylase family.

349967:HRD69 RS11760
gene id: 349967:HRD69_RS11760
uniprot id: A0A7D4T727
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.
messages: Belongs to the AcrZ family.
messages: Cell membrane
messages: Part of the AcrA-AcrB-AcrZ-TolC efflux pump, interacts directly with AcrB.

349967:HRD69 RS02815
gene id: 349967:HRD69_RS02815
uniprot id: A0A7D4PQC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 51 family.
messages: Cell inner membrane
messages: Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.

349967:HRD69 RS09525
gene id: 349967:HRD69_RS09525
uniprot id: A0A7D4SVR8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Alpha(8)-beta(8). The alpha component is a flavoprotein, the beta component is a hemoprotein.
messages: Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 FMN per subunit.
messages: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.

349967:HRD69 RS05425
gene id: 349967:HRD69_RS05425
uniprot id: A0A7D4PPF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

349967:HRD69 RS17180
gene id: 349967:HRD69_RS17180
uniprot id: A0A7D4PNE3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cleaves the N-terminal amino acid of tripeptides.
messages: Cytoplasm

349967:HRD69 RS15830
gene id: 349967:HRD69_RS15830
uniprot id: A0A7D4P9B5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA gyrase inhibitor family.
messages: Cytoplasm
messages: Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell.
messages: Interacts with DNA gyrase.

349967:HRD69 RS12130
gene id: 349967:HRD69_RS12130
uniprot id: A0A7D4PC44
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

349967:HRD69 RS11755
gene id: 349967:HRD69_RS11755
uniprot id: A0A7D4TNE7
names: Similarity
messages: Belongs to the ModE family.

349967:HRD69 RS15445
gene id: 349967:HRD69_RS15445
uniprot id: A0A7D4T7S6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

349967:HRD69 RS19915
gene id: 349967:HRD69_RS19915
uniprot id: A0A7D4P7U4
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.

349967:HRD69 RS18465
gene id: 349967:HRD69_RS18465
uniprot id: A0A7D4P577
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

349967:HRD69 RS14295
gene id: 349967:HRD69_RS14295
uniprot id: A0A7D4U021
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

349967:HRD69 RS05255
gene id: 349967:HRD69_RS05255
uniprot id: A0A7D4TJ47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

349967:HRD69 RS07040
gene id: 349967:HRD69_RS07040
uniprot id: A0A7D4PES9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family. TsaC subfamily.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.

349967:HRD69 RS05585
gene id: 349967:HRD69_RS05585
uniprot id: A0A7D4TXK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

349967:HRD69 RS10020
gene id: 349967:HRD69_RS10020
uniprot id: A0A7D4T6R2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Binds 1 Fe cation per subunit.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

349967:HRD69 RS03875
gene id: 349967:HRD69_RS03875
uniprot id: A0A7D4SV96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

349967:HRD69 RS13065
gene id: 349967:HRD69_RS13065
uniprot id: A0A7D4TZM2
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

349967:HRD69 RS16410
gene id: 349967:HRD69_RS16410
uniprot id: A0A7D4SX69
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
messages: Homohexamer, formed by a dimer of trimers.
messages: In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
messages: In the N-terminal section; belongs to the Fmt family. UDP-L-Ara4N formyltransferase subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

349967:HRD69 RS16150
gene id: 349967:HRD69_RS16150
uniprot id: A0A7D4PD77
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
messages: Homodimer.

349967:HRD69 RS01850
gene id: 349967:HRD69_RS01850
uniprot id: A0A7D4P6B9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

349967:HRD69 RS11615
gene id: 349967:HRD69_RS11615
uniprot id: A0A7D4SW53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS00010
gene id: 349967:HRD69_RS00010
uniprot id: A0A7D4THW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UreE family.
messages: Cytoplasm
messages: Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.

349967:HRD69 RS04320
gene id: 349967:HRD69_RS04320
uniprot id: A0A7D4SVC5
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

349967:HRD69 RS04290
gene id: 349967:HRD69_RS04290
uniprot id: A0A7D4P3U4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WzyE family.
messages: Cell inner membrane
messages: Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units.
messages: Probably part of a complex composed of WzxE, WzyE and WzzE.

349967:HRD69 RS01895
gene id: 349967:HRD69_RS01895
uniprot id: A0A7D4T0N1
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

349967:HRD69 RS07095
gene id: 349967:HRD69_RS07095
uniprot id: A0A7D4U205
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. GltP subfamily.
messages: Catalyzes the proton-dependent transport of glutamate and aspartate.
messages: Cell inner membrane
messages: Membrane

349967:HRD69 RS04655
gene id: 349967:HRD69_RS04655
uniprot id: A0A7D4P9V2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
messages: Cytoplasm

349967:HRD69 RS20165
gene id: 349967:HRD69_RS20165
uniprot id: A0A7D4SY47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

349967:HRD69 RS13390
gene id: 349967:HRD69_RS13390
uniprot id: A0A7D4THN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

349967:HRD69 RS16045
gene id: 349967:HRD69_RS16045
uniprot id: A0A7D4PD68
names: Similarity
messages: Belongs to the MbcT/ParT/Res family.

349967:HRD69 RS17050
gene id: 349967:HRD69_RS17050
uniprot id: A0A7D4P9L8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

349967:HRD69 RS18145
gene id: 349967:HRD69_RS18145
uniprot id: A0A7D4P553
names: Similarity
names: Subunit
messages: Belongs to the threonine aldolase family.
messages: Homotetramer.

349967:HRD69 RS04365
gene id: 349967:HRD69_RS04365
uniprot id: A0A7D4TZI2
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

349967:HRD69 RS03545
gene id: 349967:HRD69_RS03545
uniprot id: A0A7D4P3P7
names: Similarity
messages: Belongs to the aspartokinase family.