348780:NP RS10780
gene id: 348780:NP_RS10780
uniprot id: A0A1U7EYH7
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS13475
gene id: 348780:NP_RS13475
uniprot id: Q3IM30
names: Function
messages: Part of a potassium transport system.

348780:NP RS12985
gene id: 348780:NP_RS12985
uniprot id: A0A1U7EZH7
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

348780:NP RS00070
gene id: 348780:NP_RS00070
uniprot id: Q3IUS6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

348780:NP RS05900
gene id: 348780:NP_RS05900
uniprot id: Q3IRF7
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

348780:NP RS05415
gene id: 348780:NP_RS05415
uniprot id: A0A1U7EVU5
names: Function
names: Similarity
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

348780:NP RS11640
gene id: 348780:NP_RS11640
uniprot id: A0A1U7EYY4
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS11310
gene id: 348780:NP_RS11310
uniprot id: A0A1U7EYR1
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

348780:NP RS05500
gene id: 348780:NP_RS05500
uniprot id: A0A1U7EVW6
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS01690
gene id: 348780:NP_RS01690
uniprot id: A0A1U7EU12
names: Similarity
messages: Belongs to the thioesterase PaaI family.

348780:NP RS12310
gene id: 348780:NP_RS12310
uniprot id: A0A1U7EZ60
names: Similarity
messages: Belongs to the SAICAR synthetase family.

348780:NP RS03125
gene id: 348780:NP_RS03125
uniprot id: A0A1U7EUQ1
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS11170
gene id: 348780:NP_RS11170
uniprot id: Q3INF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

348780:NP RS00545
gene id: 348780:NP_RS00545
uniprot id: Q3IUI0
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

348780:NP RS02535
gene id: 348780:NP_RS02535
uniprot id: A0A1U7EUF8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

348780:NP RS01570
gene id: 348780:NP_RS01570
uniprot id: Q3ITY5
names: Similarity
messages: Belongs to the UPF0440 family.

348780:NP RS02420
gene id: 348780:NP_RS02420
uniprot id: A0A1U7EUD1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

348780:NP RS12055
gene id: 348780:NP_RS12055
uniprot id: Q3IMX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

348780:NP RS02600
gene id: 348780:NP_RS02600
uniprot id: A0A1U7EUI7
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

348780:NP RS13315
gene id: 348780:NP_RS13315
uniprot id: Q3IM62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

348780:NP RS02570
gene id: 348780:NP_RS02570
uniprot id: A0A1U7EUF9
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

348780:NP RS12030
gene id: 348780:NP_RS12030
uniprot id: Q3IMX5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

348780:NP RS05015
gene id: 348780:NP_RS05015
uniprot id: Q3IRY6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.

348780:NP RS01925
gene id: 348780:NP_RS01925
uniprot id: A0A1U7EU55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

348780:NP RS09195
gene id: 348780:NP_RS09195
uniprot id: Q3IPK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

348780:NP RS09690
gene id: 348780:NP_RS09690
uniprot id: A0A1U7EXX6
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS03920
gene id: 348780:NP_RS03920
uniprot id: A0A1U7EV58
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

348780:NP RS12045
gene id: 348780:NP_RS12045
uniprot id: Q3IMX2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

348780:NP RS02910
gene id: 348780:NP_RS02910
uniprot id: A0A1U7EUL4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

348780:NP RS01770
gene id: 348780:NP_RS01770
uniprot id: A0A1U7EU14
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

348780:NP RS13580
gene id: 348780:NP_RS13580
uniprot id: Q3IM07
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

348780:NP RS00305
gene id: 348780:NP_RS00305
uniprot id: Q3IUM8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

348780:NP RS14955
gene id: 348780:NP_RS14955
uniprot id: A0A1U7EV21
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

348780:NP RS02045
gene id: 348780:NP_RS02045
uniprot id: A0A1U7EU75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

348780:NP RS12480
gene id: 348780:NP_RS12480
uniprot id: Q3IMN2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

348780:NP RS09865
gene id: 348780:NP_RS09865
uniprot id: Q3IP66
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).

348780:NP RS01195
gene id: 348780:NP_RS01195
uniprot id: Q3IU61
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

348780:NP RS01230
gene id: 348780:NP_RS01230
uniprot id: Q3IU54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).

348780:NP RS04550
gene id: 348780:NP_RS04550
uniprot id: A0A1U7EVG0
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS01560
gene id: 348780:NP_RS01560
uniprot id: Q3ITY7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

348780:NP RS13455
gene id: 348780:NP_RS13455
uniprot id: Q3IM34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

348780:NP RS06930
gene id: 348780:NP_RS06930
uniprot id: A0A1U7EWM9
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS02620
gene id: 348780:NP_RS02620
uniprot id: A0A1U7EUH0
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.

348780:NP RS05965
gene id: 348780:NP_RS05965
uniprot id: A0A1U7EW48
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.

348780:NP RS04720
gene id: 348780:NP_RS04720
uniprot id: A0A1U7EVJ5
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

348780:NP RS00355
gene id: 348780:NP_RS00355
uniprot id: A0A1U7ETE5
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS02705
gene id: 348780:NP_RS02705
uniprot id: A0A1U7EUH8
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

348780:NP RS10115
gene id: 348780:NP_RS10115
uniprot id: A0A1U7EY52
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

348780:NP RS06915
gene id: 348780:NP_RS06915
uniprot id: A0A1U7EWN5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

348780:NP RS07765
gene id: 348780:NP_RS07765
uniprot id: A0A1U7EX16
names: Similarity
messages: Belongs to the SCO1/2 family.

348780:NP RS01890
gene id: 348780:NP_RS01890
uniprot id: A0A1U7EU42
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

348780:NP RS12035
gene id: 348780:NP_RS12035
uniprot id: Q3IMX4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

348780:NP RS04495
gene id: 348780:NP_RS04495
uniprot id: A0A1U7EVE9
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS11060
gene id: 348780:NP_RS11060
uniprot id: A0A1U7EYM8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

348780:NP RS10805
gene id: 348780:NP_RS10805
uniprot id: A0A1U7EYG3
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS12950
gene id: 348780:NP_RS12950
uniprot id: A0A1U7EZJ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in both the arginine and lysine biosynthetic pathways.

348780:NP RS00220
gene id: 348780:NP_RS00220
uniprot id: A0A1U7ETC1
names: Similarity
messages: Belongs to the UPF0215 family.

348780:NP RS13645
gene id: 348780:NP_RS13645
uniprot id: Q3ILZ3
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS07955
gene id: 348780:NP_RS07955
uniprot id: Q3IQA0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

348780:NP RS00270
gene id: 348780:NP_RS00270
uniprot id: A0A1U7ETD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

348780:NP RS02905
gene id: 348780:NP_RS02905
uniprot id: Q3IT64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

348780:NP RS07375
gene id: 348780:NP_RS07375
uniprot id: Q3IQL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

348780:NP RS03575
gene id: 348780:NP_RS03575
uniprot id: A0A1U7EUX3
names: Similarity
messages: Belongs to the AOR/FOR family.

348780:NP RS02365
gene id: 348780:NP_RS02365
uniprot id: A0A1U7EUB8
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

348780:NP RS07115
gene id: 348780:NP_RS07115
uniprot id: A0A1U7EWP6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

348780:NP RS05435
gene id: 348780:NP_RS05435
uniprot id: A0A1U7EVX4
names: Similarity
messages: Belongs to the acetolactate synthase small subunit family.

348780:NP RS11975
gene id: 348780:NP_RS11975
uniprot id: Q3IMY6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

348780:NP RS00480
gene id: 348780:NP_RS00480
uniprot id: A0A1U7ETG2
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS10585
gene id: 348780:NP_RS10585
uniprot id: A0A1U7EYB5
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

348780:NP RS04880
gene id: 348780:NP_RS04880
uniprot id: Q3IS14
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

348780:NP RS00685
gene id: 348780:NP_RS00685
uniprot id: Q3IUF3
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

348780:NP RS09260
gene id: 348780:NP_RS09260
uniprot id: Q3IPI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

348780:NP RS09270
gene id: 348780:NP_RS09270
uniprot id: Q3IPI5
names: Similarity
messages: Belongs to the acylphosphatase family.

348780:NP RS04035
gene id: 348780:NP_RS04035
uniprot id: Q3ISI7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

348780:NP RS04365
gene id: 348780:NP_RS04365
uniprot id: A0A1U7EVD0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

348780:NP RS04455
gene id: 348780:NP_RS04455
uniprot id: A0A1U7EVD1
names: Similarity
messages: Belongs to the glutamate synthase family.

348780:NP RS00170
gene id: 348780:NP_RS00170
uniprot id: Q3IUQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

348780:NP RS00155
gene id: 348780:NP_RS00155
uniprot id: A0A1U7ETB0
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

348780:NP RS07045
gene id: 348780:NP_RS07045
uniprot id: A0A1U7EWP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

348780:NP RS03515
gene id: 348780:NP_RS03515
uniprot id: Q3ISU0
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

348780:NP RS11015
gene id: 348780:NP_RS11015
uniprot id: A0A1U7EYK4
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

348780:NP RS01765
gene id: 348780:NP_RS01765
uniprot id: Q3ITU5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

348780:NP RS13820
gene id: 348780:NP_RS13820
uniprot id: Q3ILV6
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

348780:NP RS06600
gene id: 348780:NP_RS06600
uniprot id: A0A1U7EWG5
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS05350
gene id: 348780:NP_RS05350
uniprot id: A0A1U7EVT8
names: Function
names: Subunit
messages: Interacts with chemotaxis (Che) proteins as well as flagella accessory (Fla) proteins.
messages: Involved in taxis signal transduction.

348780:NP RS06635
gene id: 348780:NP_RS06635
uniprot id: A0A1U7EWH3
names: Similarity
messages: Belongs to the CutA family.

348780:NP RS09720
gene id: 348780:NP_RS09720
uniprot id: A0A1U7EXW7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

348780:NP RS04700
gene id: 348780:NP_RS04700
uniprot id: A0A1U7EVJ2
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

348780:NP RS08860
gene id: 348780:NP_RS08860
uniprot id: A0A1U7EXH6
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS03530
gene id: 348780:NP_RS03530
uniprot id: A0A1U7EUZ8
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS01145
gene id: 348780:NP_RS01145
uniprot id: A0A1U7ETQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm

348780:NP RS06490
gene id: 348780:NP_RS06490
uniprot id: A0A1U7EWF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-H(4)MPT.
messages: Cytoplasm

348780:NP RS11660
gene id: 348780:NP_RS11660
uniprot id: A0A1U7EYY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

348780:NP RS13585
gene id: 348780:NP_RS13585
uniprot id: Q3IM05
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

348780:NP RS12025
gene id: 348780:NP_RS12025
uniprot id: Q3IMX6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

348780:NP RS12335
gene id: 348780:NP_RS12335
uniprot id: Q3IMR2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

348780:NP RS01850
gene id: 348780:NP_RS01850
uniprot id: Q3ITS6
names: Function
names: Similarity
messages: Belongs to the archaeal IMP cyclohydrolase family.
messages: Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.

348780:NP RS05455
gene id: 348780:NP_RS05455
uniprot id: Q3IRP7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

348780:NP RS12105
gene id: 348780:NP_RS12105
uniprot id: Q3IMW0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.

348780:NP RS10675
gene id: 348780:NP_RS10675
uniprot id: A0A1U7EYF6
names: Similarity
messages: Belongs to the UPF0212 family.

348780:NP RS06400
gene id: 348780:NP_RS06400
uniprot id: A0A1U7EWD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

348780:NP RS11205
gene id: 348780:NP_RS11205
uniprot id: Q3INE3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Binds two Mg(2+) per subunit.
messages: Forms a ternary complex with MCM helicase and DNA.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

348780:NP RS07890
gene id: 348780:NP_RS07890
uniprot id: A0A1U7EX32
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

348780:NP RS03940
gene id: 348780:NP_RS03940
uniprot id: A0A1U7EV45
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS08105
gene id: 348780:NP_RS08105
uniprot id: A0A1U7EX70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

348780:NP RS13630
gene id: 348780:NP_RS13630
uniprot id: Q3ILZ6
names: Similarity
messages: Belongs to the AOR/FOR family.

348780:NP RS00540
gene id: 348780:NP_RS00540
uniprot id: Q3IUI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

348780:NP RS00055
gene id: 348780:NP_RS00055
uniprot id: A0A1U7ET95
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.

348780:NP RS11860
gene id: 348780:NP_RS11860
uniprot id: A0A1U7EYZ3
names: Similarity
messages: Belongs to the MoaB/Mog family.

348780:NP RS08555
gene id: 348780:NP_RS08555
uniprot id: A0A1U7EXC1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

348780:NP RS12320
gene id: 348780:NP_RS12320
uniprot id: A0A1U7EZ81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

348780:NP RS03725
gene id: 348780:NP_RS03725
uniprot id: Q3ISQ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

348780:NP RS12350
gene id: 348780:NP_RS12350
uniprot id: A0A1U7EZ98
names: Similarity
messages: Belongs to the AOR/FOR family.

348780:NP RS05650
gene id: 348780:NP_RS05650
uniprot id: A0A1U7EVY0
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

348780:NP RS03520
gene id: 348780:NP_RS03520
uniprot id: A0A1U7EUW3
names: Similarity
messages: Belongs to the IMPACT family.

348780:NP RS04210
gene id: 348780:NP_RS04210
uniprot id: A0A1U7EV99
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

348780:NP RS04985
gene id: 348780:NP_RS04985
uniprot id: Q3IRZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreD family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

348780:NP RS05155
gene id: 348780:NP_RS05155
uniprot id: A0A1U7EVQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

348780:NP RS09940
gene id: 348780:NP_RS09940
uniprot id: A0A1U7EY27
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS12960
gene id: 348780:NP_RS12960
uniprot id: A0A1U7EZJ6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

348780:NP RS07100
gene id: 348780:NP_RS07100
uniprot id: A0A1U7EWQ1
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

348780:NP RS05540
gene id: 348780:NP_RS05540
uniprot id: A0A1U7EVZ5
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

348780:NP RS01660
gene id: 348780:NP_RS01660
uniprot id: A0A1U7ETZ9
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS06050
gene id: 348780:NP_RS06050
uniprot id: A0A1U7EW66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

348780:NP RS09350
gene id: 348780:NP_RS09350
uniprot id: A0A1U7EXS0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

348780:NP RS11385
gene id: 348780:NP_RS11385
uniprot id: A0A1U7EYT4
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS07640
gene id: 348780:NP_RS07640
uniprot id: A0A1U7EWZ6
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

348780:NP RS05520
gene id: 348780:NP_RS05520
uniprot id: Q3IRN3
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

348780:NP RS04330
gene id: 348780:NP_RS04330
uniprot id: A0A1U7EVB9
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

348780:NP RS04750
gene id: 348780:NP_RS04750
uniprot id: A0A1U7EVL3
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the NOS family. Bacterial NOS oxygenase subfamily.
messages: Catalyzes the production of nitric oxide.
messages: Homodimer.
messages: This protein is similar to the oxygenase domain of eukaryotic nitric oxide synthases but lacks the reductase domain which, in eukaryotes, is responsible for transfer of electrons to the ferric heme during nitric oxide synthesis.

348780:NP RS02320
gene id: 348780:NP_RS02320
uniprot id: A0A1U7EUA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P(II) protein family.
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Membrane

348780:NP RS04245
gene id: 348780:NP_RS04245
uniprot id: A0A1U7EVB6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

348780:NP RS02460
gene id: 348780:NP_RS02460
uniprot id: A0A1U7EUG3
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

348780:NP RS02970
gene id: 348780:NP_RS02970
uniprot id: A0A1U7EUN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

348780:NP RS03120
gene id: 348780:NP_RS03120
uniprot id: Q3IT20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

348780:NP RS00615
gene id: 348780:NP_RS00615
uniprot id: Q3IUG6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

348780:NP RS03830
gene id: 348780:NP_RS03830
uniprot id: Q3ISN0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

348780:NP RS01865
gene id: 348780:NP_RS01865
uniprot id: A0A1U7EU45
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

348780:NP RS02110
gene id: 348780:NP_RS02110
uniprot id: Q3ITM2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

348780:NP RS00050
gene id: 348780:NP_RS00050
uniprot id: A0A1U7ET92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

348780:NP RS06755
gene id: 348780:NP_RS06755
uniprot id: Q3IQY5
names: Function
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
messages: Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).

348780:NP RS11470
gene id: 348780:NP_RS11470
uniprot id: A0A1U7EYU8
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

348780:NP RS01370
gene id: 348780:NP_RS01370
uniprot id: A0A1U7ETV1
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

348780:NP RS09115
gene id: 348780:NP_RS09115
uniprot id: A0A1U7EXN7
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 zinc ion.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

348780:NP RS10160
gene id: 348780:NP_RS10160
uniprot id: Q3IP06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

348780:NP RS05980
gene id: 348780:NP_RS05980
uniprot id: A0A1U7EW53
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

348780:NP RS13810
gene id: 348780:NP_RS13810
uniprot id: Q3ILV8
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS02425
gene id: 348780:NP_RS02425
uniprot id: A0A1U7EUE3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

348780:NP RS12115
gene id: 348780:NP_RS12115
uniprot id: Q3IMV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

348780:NP RS01545
gene id: 348780:NP_RS01545
uniprot id: A0A1U7ETY1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

348780:NP RS00580
gene id: 348780:NP_RS00580
uniprot id: Q3IUH3
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

348780:NP RS11760
gene id: 348780:NP_RS11760
uniprot id: Q3IN28
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

348780:NP RS07835
gene id: 348780:NP_RS07835
uniprot id: A0A1U7EX21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

348780:NP RS07085
gene id: 348780:NP_RS07085
uniprot id: A0A1U7EWP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

348780:NP RS00655
gene id: 348780:NP_RS00655
uniprot id: A0A1U7ETI9
names: Subcellular Location Annotation
messages: Cell membrane

348780:NP RS02415
gene id: 348780:NP_RS02415
uniprot id: A0A1U7EUD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

348780:NP RS06805
gene id: 348780:NP_RS06805
uniprot id: A0A1U7EWJ8
names: Similarity
messages: Belongs to the thioesterase PaaI family.

348780:NP RS12405
gene id: 348780:NP_RS12405
uniprot id: A0A1U7EZA6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

348780:NP RS01290
gene id: 348780:NP_RS01290
uniprot id: A0A1U7ETU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

348780:NP RS02660
gene id: 348780:NP_RS02660
uniprot id: Q3ITB2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

348780:NP RS01655
gene id: 348780:NP_RS01655
uniprot id: A0A1U7EU06
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Brp/Blh beta-carotene diooxygenase family.
messages: Catalyzes the cleavage of beta-carotene at its central double bond (15,15') to yield two molecules of all-trans-retinal.
messages: Cell membrane

348780:NP RS12070
gene id: 348780:NP_RS12070
uniprot id: Q3IMW7
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

348780:NP RS03950
gene id: 348780:NP_RS03950
uniprot id: A0A1U7EV49
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

348780:NP RS02310
gene id: 348780:NP_RS02310
uniprot id: A0A1U7EUC3
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

348780:NP RS00430
gene id: 348780:NP_RS00430
uniprot id: A0A1U7ETF4
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS12040
gene id: 348780:NP_RS12040
uniprot id: Q3IMX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

348780:NP RS11300
gene id: 348780:NP_RS11300
uniprot id: A0A1U7EYR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

348780:NP RS05570
gene id: 348780:NP_RS05570
uniprot id: Q3IRM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

348780:NP RS09080
gene id: 348780:NP_RS09080
uniprot id: A0A1U7EXL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

348780:NP RS10955
gene id: 348780:NP_RS10955
uniprot id: A0A1U7EYK1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

348780:NP RS08340
gene id: 348780:NP_RS08340
uniprot id: Q3IQ21
names: Function
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
messages: Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC), the main low-molecular-weight thiol compound instead of glutathione in halophilic archaea.

348780:NP RS07215
gene id: 348780:NP_RS07215
uniprot id: A0A1U7EWR9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.

348780:NP RS09740
gene id: 348780:NP_RS09740
uniprot id: A0A1U7EXY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

348780:NP RS00035
gene id: 348780:NP_RS00035
uniprot id: Q3IUT3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

348780:NP RS05390
gene id: 348780:NP_RS05390
uniprot id: A0A1U7EVU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

348780:NP RS02900
gene id: 348780:NP_RS02900
uniprot id: A0A1U7EUM1
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS05255
gene id: 348780:NP_RS05255
uniprot id: Q3IRT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

348780:NP RS03100
gene id: 348780:NP_RS03100
uniprot id: Q3IT24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

348780:NP RS02545
gene id: 348780:NP_RS02545
uniprot id: Q3ITD5
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

348780:NP RS02710
gene id: 348780:NP_RS02710
uniprot id: A0A1U7EUH5
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS12275
gene id: 348780:NP_RS12275
uniprot id: Q3IMS5
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

348780:NP RS10375
gene id: 348780:NP_RS10375
uniprot id: A0A1U7EY89
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

348780:NP RS10920
gene id: 348780:NP_RS10920
uniprot id: A0A1U7EYJ0
names: Similarity
messages: Belongs to the HAM1 NTPase family.

348780:NP RS06800
gene id: 348780:NP_RS06800
uniprot id: A0A1U7EWJ0
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

348780:NP RS01040
gene id: 348780:NP_RS01040
uniprot id: A0A1U7ETP6
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

348780:NP RS03720
gene id: 348780:NP_RS03720
uniprot id: A0A1U7EV14
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

348780:NP RS03500
gene id: 348780:NP_RS03500
uniprot id: A0A1U7EUW7
names: Similarity
messages: Belongs to the thioesterase PaaI family.

348780:NP RS13690
gene id: 348780:NP_RS13690
uniprot id: Q3ILY4
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase family.
messages: Binds 1 FAD per subunit.

348780:NP RS13055
gene id: 348780:NP_RS13055
uniprot id: A0A1U7EZM2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

348780:NP RS04360
gene id: 348780:NP_RS04360
uniprot id: A0A1U7EVD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

348780:NP RS02265
gene id: 348780:NP_RS02265
uniprot id: Q3ITJ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

348780:NP RS11215
gene id: 348780:NP_RS11215
uniprot id: A0A1U7EYM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

348780:NP RS06195
gene id: 348780:NP_RS06195
uniprot id: Q3IR98
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

348780:NP RS03800
gene id: 348780:NP_RS03800
uniprot id: Q3ISN6
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

348780:NP RS03370
gene id: 348780:NP_RS03370
uniprot id: A0A1U7EUV0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

348780:NP RS12485
gene id: 348780:NP_RS12485
uniprot id: A0A1U7EZA7
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Part of the 30S ribosomal subunit.

348780:NP RS07570
gene id: 348780:NP_RS07570
uniprot id: A0A1U7EWX9
names: Similarity
messages: Belongs to the Ahb/Nir family.

348780:NP RS01960
gene id: 348780:NP_RS01960
uniprot id: Q3ITQ4
names: Similarity
messages: Belongs to the UPF0213 family.

348780:NP RS10530
gene id: 348780:NP_RS10530
uniprot id: A0A1U7EYC8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

348780:NP RS04340
gene id: 348780:NP_RS04340
uniprot id: A0A1U7EVB1
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

348780:NP RS03730
gene id: 348780:NP_RS03730
uniprot id: Q3ISP9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

348780:NP RS00425
gene id: 348780:NP_RS00425
uniprot id: A0A1U7ETE7
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS09830
gene id: 348780:NP_RS09830
uniprot id: Q3IP72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

348780:NP RS06725
gene id: 348780:NP_RS06725
uniprot id: A0A1U7EWJ1
names: Similarity
messages: Belongs to the isochorismate synthase family.

348780:NP RS04460
gene id: 348780:NP_RS04460
uniprot id: Q3IS99
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

348780:NP RS11720
gene id: 348780:NP_RS11720
uniprot id: A0A1U7EYZ5
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS00720
gene id: 348780:NP_RS00720
uniprot id: Q3IUE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NAD to NADH.
messages: Homotetramer.

348780:NP RS10685
gene id: 348780:NP_RS10685
uniprot id: A0A1U7EYD4
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

348780:NP RS09425
gene id: 348780:NP_RS09425
uniprot id: Q3IPF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

348780:NP RS04370
gene id: 348780:NP_RS04370
uniprot id: A0A1U7EVC5
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

348780:NP RS12615
gene id: 348780:NP_RS12615
uniprot id: A0A1U7EZC8
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

348780:NP RS09005
gene id: 348780:NP_RS09005
uniprot id: A0A1U7EXJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

348780:NP RS09095
gene id: 348780:NP_RS09095
uniprot id: A0A1U7EXM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

348780:NP RS10765
gene id: 348780:NP_RS10765
uniprot id: Q3INN3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

348780:NP RS09825
gene id: 348780:NP_RS09825
uniprot id: Q3IP73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

348780:NP RS13095
gene id: 348780:NP_RS13095
uniprot id: A0A1U7EZM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

348780:NP RS02930
gene id: 348780:NP_RS02930
uniprot id: Q3IT59
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.

348780:NP RS05665
gene id: 348780:NP_RS05665
uniprot id: A0A1U7EW14
names: Similarity
messages: In the C-terminal section; belongs to the complex I 49 kDa subunit family.

348780:NP RS06030
gene id: 348780:NP_RS06030
uniprot id: A0A1U7EW63
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

348780:NP RS10665
gene id: 348780:NP_RS10665
uniprot id: Q3INQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

348780:NP RS11740
gene id: 348780:NP_RS11740
uniprot id: A0A1U7EYX3
names: Subcellular Location Annotation
messages: Cell membrane

348780:NP RS09815
gene id: 348780:NP_RS09815
uniprot id: A0A1U7EY08
names: Similarity
messages: Belongs to the GARS family.

348780:NP RS06920
gene id: 348780:NP_RS06920
uniprot id: A0A1U7EWM4
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

348780:NP RS12500
gene id: 348780:NP_RS12500
uniprot id: A0A1U7EZB1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

348780:NP RS05575
gene id: 348780:NP_RS05575
uniprot id: A0A1U7EVY3
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

348780:NP RS10195
gene id: 348780:NP_RS10195
uniprot id: A0A1U7EY78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

348780:NP RS03195
gene id: 348780:NP_RS03195
uniprot id: A0A1U7EUT4
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS09075
gene id: 348780:NP_RS09075
uniprot id: A0A1U7EXL9
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

348780:NP RS11475
gene id: 348780:NP_RS11475
uniprot id: A0A1U7EYS6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

348780:NP RS04485
gene id: 348780:NP_RS04485
uniprot id: A0A1U7EVE4
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

348780:NP RS01150
gene id: 348780:NP_RS01150
uniprot id: Q3IU70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp (By similarity).
messages: Homodimer.

348780:NP RS02990
gene id: 348780:NP_RS02990
uniprot id: Q3IT47
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

348780:NP RS05625
gene id: 348780:NP_RS05625
uniprot id: A0A1U7EVY8
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

348780:NP RS02015
gene id: 348780:NP_RS02015
uniprot id: A0A1U7EU73
names: Subunit
messages: Tetramer of two components I and two components II.

348780:NP RS07040
gene id: 348780:NP_RS07040
uniprot id: Q3IQS9
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

348780:NP RS06320
gene id: 348780:NP_RS06320
uniprot id: A0A1U7EWA0
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

348780:NP RS12180
gene id: 348780:NP_RS12180
uniprot id: A0A1U7EZ34
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

348780:NP RS03490
gene id: 348780:NP_RS03490
uniprot id: A0A1U7EUW6
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS04930
gene id: 348780:NP_RS04930
uniprot id: Q3IS04
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

348780:NP RS08490
gene id: 348780:NP_RS08490
uniprot id: A0A1U7EXC9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

348780:NP RS12940
gene id: 348780:NP_RS12940
uniprot id: Q3IMD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways.

348780:NP RS06255
gene id: 348780:NP_RS06255
uniprot id: A0A1U7EW98
names: Similarity
messages: Belongs to the glutaredoxin family.

348780:NP RS00300
gene id: 348780:NP_RS00300
uniprot id: A0A1U7ETD0
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS07615
gene id: 348780:NP_RS07615
uniprot id: A0A1U7EX14
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

348780:NP RS08695
gene id: 348780:NP_RS08695
uniprot id: Q3IPU8
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

348780:NP RS09205
gene id: 348780:NP_RS09205
uniprot id: A0A1U7EXP7
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS12895
gene id: 348780:NP_RS12895
uniprot id: A0A1U7EZJ0
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

348780:NP RS02435
gene id: 348780:NP_RS02435
uniprot id: Q3ITF7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.

348780:NP RS03005
gene id: 348780:NP_RS03005
uniprot id: A0A1U7EUN0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

348780:NP RS04805
gene id: 348780:NP_RS04805
uniprot id: A0A1U7EVK7
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

348780:NP RS04915
gene id: 348780:NP_RS04915
uniprot id: Q3IS07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
messages: Cell membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

348780:NP RS00455
gene id: 348780:NP_RS00455
uniprot id: A0A1U7ETF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

348780:NP RS04920
gene id: 348780:NP_RS04920
uniprot id: Q3IS06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

348780:NP RS08650
gene id: 348780:NP_RS08650
uniprot id: A0A1U7EXE3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

348780:NP RS05370
gene id: 348780:NP_RS05370
uniprot id: Q3IRR4
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

348780:NP RS12765
gene id: 348780:NP_RS12765
uniprot id: Q3IMH6
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

348780:NP RS06590
gene id: 348780:NP_RS06590
uniprot id: A0A1U7EWI8
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

348780:NP RS04220
gene id: 348780:NP_RS04220
uniprot id: A0A1U7EV91
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

348780:NP RS05095
gene id: 348780:NP_RS05095
uniprot id: A0A1U7EVP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

348780:NP RS02635
gene id: 348780:NP_RS02635
uniprot id: Q3ITB6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofE family.
messages: Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.
messages: Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
messages: Homodimer.
messages: Monovalent cation. The ion could be potassium.

348780:NP RS08385
gene id: 348780:NP_RS08385
uniprot id: A0A1U7EXA7
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

348780:NP RS05440
gene id: 348780:NP_RS05440
uniprot id: A0A1U7EVW2
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

348780:NP RS05065
gene id: 348780:NP_RS05065
uniprot id: A0A1U7EVR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane

348780:NP RS06690
gene id: 348780:NP_RS06690
uniprot id: A0A1U7EWH7
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

348780:NP RS10760
gene id: 348780:NP_RS10760
uniprot id: A0A1U7EYG8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

348780:NP RS00595
gene id: 348780:NP_RS00595
uniprot id: A0A1U7ETI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

348780:NP RS04965
gene id: 348780:NP_RS04965
uniprot id: Q3IRZ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

348780:NP RS03000
gene id: 348780:NP_RS03000
uniprot id: A0A1U7EUM2
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

348780:NP RS03045
gene id: 348780:NP_RS03045
uniprot id: A0A1U7EUN2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for chromosome condensation and partitioning.

348780:NP RS07935
gene id: 348780:NP_RS07935
uniprot id: Q3IQA4
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

348780:NP RS00240
gene id: 348780:NP_RS00240
uniprot id: Q3IUP1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

348780:NP RS07470
gene id: 348780:NP_RS07470
uniprot id: A0A1U7EWX2
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

348780:NP RS07455
gene id: 348780:NP_RS07455
uniprot id: A0A1U7EWW5
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

348780:NP RS11070
gene id: 348780:NP_RS11070
uniprot id: A0A1U7EYM5
names: Similarity
messages: Belongs to the PdaD family.

348780:NP RS03060
gene id: 348780:NP_RS03060
uniprot id: A0A1U7EUR4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

348780:NP RS12000
gene id: 348780:NP_RS12000
uniprot id: Q3IMY1
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

348780:NP RS12710
gene id: 348780:NP_RS12710
uniprot id: A0A1U7EZD4
names: Similarity
messages: Belongs to the phosphohexose mutase family.

348780:NP RS01200
gene id: 348780:NP_RS01200
uniprot id: Q3IU60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

348780:NP RS12220
gene id: 348780:NP_RS12220
uniprot id: A0A1U7EZ74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

348780:NP RS04375
gene id: 348780:NP_RS04375
uniprot id: A0A1U7EVD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal/bacterial/fungal opsin family.
messages: Membrane

348780:NP RS04910
gene id: 348780:NP_RS04910
uniprot id: A0A1U7EVL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

348780:NP RS08990
gene id: 348780:NP_RS08990
uniprot id: A0A1U7EXM0
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

348780:NP RS11910
gene id: 348780:NP_RS11910
uniprot id: A0A1U7EZ03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal/bacterial/fungal opsin family.
messages: Membrane

348780:NP RS08965
gene id: 348780:NP_RS08965
uniprot id: A0A1U7EXK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

348780:NP RS05580
gene id: 348780:NP_RS05580
uniprot id: Q3IRM1
names: Similarity
messages: In the N-terminal section; belongs to the ChdC family.

348780:NP RS00840
gene id: 348780:NP_RS00840
uniprot id: A0A1U7ETL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

348780:NP RS00325
gene id: 348780:NP_RS00325
uniprot id: Q3IUM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

348780:NP RS02145
gene id: 348780:NP_RS02145
uniprot id: A0A1U7EU92
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

348780:NP RS07925
gene id: 348780:NP_RS07925
uniprot id: A0A1U7EX46
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

348780:NP RS09435
gene id: 348780:NP_RS09435
uniprot id: A0A1U7EXS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

348780:NP RS12790
gene id: 348780:NP_RS12790
uniprot id: A0A1U7EZE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

348780:NP RS10280
gene id: 348780:NP_RS10280
uniprot id: Q3INY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

348780:NP RS12020
gene id: 348780:NP_RS12020
uniprot id: Q3IMX7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

348780:NP RS03560
gene id: 348780:NP_RS03560
uniprot id: Q3IST1
names: Function
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: May catalyze a purine salvage reaction, the substrate is unknown.

348780:NP RS07015
gene id: 348780:NP_RS07015
uniprot id: Q3IQT4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

348780:NP RS04345
gene id: 348780:NP_RS04345
uniprot id: A0A1U7EVC8
names: Similarity
messages: Belongs to the pyruvate kinase family.
messages: In the C-terminal section; belongs to the PEP-utilizing enzyme family.

348780:NP RS12515
gene id: 348780:NP_RS12515
uniprot id: Q3IMM5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

348780:NP RS07195
gene id: 348780:NP_RS07195
uniprot id: A0A1U7EWS2
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS06680
gene id: 348780:NP_RS06680
uniprot id: Q3IQZ9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.

348780:NP RS07590
gene id: 348780:NP_RS07590
uniprot id: A0A1U7EWY7
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

348780:NP RS05285
gene id: 348780:NP_RS05285
uniprot id: Q3IRT1
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

348780:NP RS02440
gene id: 348780:NP_RS02440
uniprot id: A0A1U7EUE1
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

348780:NP RS06740
gene id: 348780:NP_RS06740
uniprot id: Q3IQY8
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

348780:NP RS09045
gene id: 348780:NP_RS09045
uniprot id: Q3IPM8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

348780:NP RS13505
gene id: 348780:NP_RS13505
uniprot id: Q3IM24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
messages: Cell membrane
messages: Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PhnC), two transmembrane proteins (PhnE) and a solute-binding protein (PhnD).

348780:NP RS11335
gene id: 348780:NP_RS11335
uniprot id: Q3INB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

348780:NP RS05560
gene id: 348780:NP_RS05560
uniprot id: Q3IRM5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

348780:NP RS05335
gene id: 348780:NP_RS05335
uniprot id: A0A1U7EVT6
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS08345
gene id: 348780:NP_RS08345
uniprot id: A0A1U7EX85
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

348780:NP RS13500
gene id: 348780:NP_RS13500
uniprot id: Q3IM25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

348780:NP RS12700
gene id: 348780:NP_RS12700
uniprot id: Q3IMJ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

348780:NP RS13800
gene id: 348780:NP_RS13800
uniprot id: Q3ILW0
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS09855
gene id: 348780:NP_RS09855
uniprot id: A0A1U7EY01
names: Similarity
messages: Belongs to the archease family.

348780:NP RS07840
gene id: 348780:NP_RS07840
uniprot id: A0A1U7EX27
names: Similarity
messages: Belongs to the TrpC family.

348780:NP RS06115
gene id: 348780:NP_RS06115
uniprot id: Q3IRB3
names: Similarity
messages: Belongs to the thymidylate kinase family.

348780:NP RS10470
gene id: 348780:NP_RS10470
uniprot id: A0A1U7EYB1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

348780:NP RS02510
gene id: 348780:NP_RS02510
uniprot id: Q3ITE2
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

348780:NP RS11180
gene id: 348780:NP_RS11180
uniprot id: Q3INE8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

348780:NP RS15030
gene id: 348780:NP_RS15030
uniprot id: Q3ILZ0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

348780:NP RS00030
gene id: 348780:NP_RS00030
uniprot id: A0A1U7ET89
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

348780:NP RS01950
gene id: 348780:NP_RS01950
uniprot id: A0A1U7EU68
names: Similarity
messages: Belongs to the UPF0146 family.

348780:NP RS07810
gene id: 348780:NP_RS07810
uniprot id: A0A1U7EX25
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

348780:NP RS02630
gene id: 348780:NP_RS02630
uniprot id: Q3ITB7
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

348780:NP RS04265
gene id: 348780:NP_RS04265
uniprot id: A0A1U7EVA7
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

348780:NP RS07480
gene id: 348780:NP_RS07480
uniprot id: A0A1U7EWX1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

348780:NP RS00110
gene id: 348780:NP_RS00110
uniprot id: A0A1U7ET98
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS01375
gene id: 348780:NP_RS01375
uniprot id: A0A1U7ETU6
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA.

348780:NP RS06855
gene id: 348780:NP_RS06855
uniprot id: A0A1U7EWL3
names: Similarity
messages: Belongs to the peptidase S45 family.

348780:NP RS12925
gene id: 348780:NP_RS12925
uniprot id: Q3IME1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

348780:NP RS08485
gene id: 348780:NP_RS08485
uniprot id: A0A1U7EXC4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

348780:NP RS13480
gene id: 348780:NP_RS13480
uniprot id: Q3IM29
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS02725
gene id: 348780:NP_RS02725
uniprot id: Q3ITA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

348780:NP RS08255
gene id: 348780:NP_RS08255
uniprot id: Q3IQ38
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

348780:NP RS03945
gene id: 348780:NP_RS03945
uniprot id: Q3ISK5
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.

348780:NP RS08685
gene id: 348780:NP_RS08685
uniprot id: A0A1U7EXE5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

348780:NP RS11645
gene id: 348780:NP_RS11645
uniprot id: A0A1U7EYY7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

348780:NP RS02560
gene id: 348780:NP_RS02560
uniprot id: A0A1U7EUG1
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS04190
gene id: 348780:NP_RS04190
uniprot id: A0A1U7EVA0
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

348780:NP RS12505
gene id: 348780:NP_RS12505
uniprot id: A0A1U7EZC2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

348780:NP RS03395
gene id: 348780:NP_RS03395
uniprot id: Q3ISW4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe).

348780:NP RS05070
gene id: 348780:NP_RS05070
uniprot id: Q3IRX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

348780:NP RS04525
gene id: 348780:NP_RS04525
uniprot id: A0A1U7EVH4
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

348780:NP RS01240
gene id: 348780:NP_RS01240
uniprot id: A0A1U7ETT3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

348780:NP RS08330
gene id: 348780:NP_RS08330
uniprot id: A0A1U7EX98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

348780:NP RS10475
gene id: 348780:NP_RS10475
uniprot id: A0A1U7EYB7
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

348780:NP RS06985
gene id: 348780:NP_RS06985
uniprot id: Q3IQT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

348780:NP RS11020
gene id: 348780:NP_RS11020
uniprot id: A0A1U7EYL1
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS02675
gene id: 348780:NP_RS02675
uniprot id: A0A1U7EUI4
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

348780:NP RS05735
gene id: 348780:NP_RS05735
uniprot id: Q3IRJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

348780:NP RS10605
gene id: 348780:NP_RS10605
uniprot id: Q3INR7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.

348780:NP RS09340
gene id: 348780:NP_RS09340
uniprot id: A0A1U7EXR9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

348780:NP RS07875
gene id: 348780:NP_RS07875
uniprot id: A0A1U7EX36
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS03585
gene id: 348780:NP_RS03585
uniprot id: A0A1U7EUY1
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS06540
gene id: 348780:NP_RS06540
uniprot id: A0A1U7EWG4
names: Similarity
messages: Belongs to the peptidase S8 family.

348780:NP RS12545
gene id: 348780:NP_RS12545
uniprot id: A0A1U7EZC0
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

348780:NP RS02995
gene id: 348780:NP_RS02995
uniprot id: Q3IT46
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-aspartate to produce beta-alanine.

348780:NP RS08470
gene id: 348780:NP_RS08470
uniprot id: A0A1U7EXB3
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS06965
gene id: 348780:NP_RS06965
uniprot id: A0A1U7EWQ5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

348780:NP RS08280
gene id: 348780:NP_RS08280
uniprot id: A0A1U7EX71
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS09170
gene id: 348780:NP_RS09170
uniprot id: A0A1U7EXN1
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

348780:NP RS02965
gene id: 348780:NP_RS02965
uniprot id: A0A1U7EUM5
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

348780:NP RS08645
gene id: 348780:NP_RS08645
uniprot id: A0A1U7EXE0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

348780:NP RS07885
gene id: 348780:NP_RS07885
uniprot id: A0A1U7EX42
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

348780:NP RS13485
gene id: 348780:NP_RS13485
uniprot id: Q3IM28
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

348780:NP RS00275
gene id: 348780:NP_RS00275
uniprot id: A0A1U7ETD3
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Part of the RNA polymerase complex.

348780:NP RS00855
gene id: 348780:NP_RS00855
uniprot id: A0A1U7ETM5
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

348780:NP RS00395
gene id: 348780:NP_RS00395
uniprot id: Q3IUL0
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS09950
gene id: 348780:NP_RS09950
uniprot id: A0A1U7EY22
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

348780:NP RS01860
gene id: 348780:NP_RS01860
uniprot id: A0A1U7EU40
names: Similarity
messages: Belongs to the UPF0284 family.

348780:NP RS09050
gene id: 348780:NP_RS09050
uniprot id: A0A1U7EXM6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds to the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

348780:NP RS05080
gene id: 348780:NP_RS05080
uniprot id: Q3IRX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

348780:NP RS04355
gene id: 348780:NP_RS04355
uniprot id: Q3ISC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.
messages: Cell membrane
messages: Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PhnC), two transmembrane proteins (PhnE) and a solute-binding protein (PhnD).

348780:NP RS03465
gene id: 348780:NP_RS03465
uniprot id: A0A1U7EUV2
names: Subcellular Location Annotation
messages: Cytoplasm

348780:NP RS10430
gene id: 348780:NP_RS10430
uniprot id: A0A1U7EY90
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

348780:NP RS10465
gene id: 348780:NP_RS10465
uniprot id: A0A1U7EYA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Membrane

348780:NP RS05865
gene id: 348780:NP_RS05865
uniprot id: A0A1U7EW24
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

348780:NP RS06695
gene id: 348780:NP_RS06695
uniprot id: A0A1U7EWI5
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

348780:NP RS06205
gene id: 348780:NP_RS06205
uniprot id: Q3IR96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

348780:NP RS05380
gene id: 348780:NP_RS05380
uniprot id: A0A1U7EVV2
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

348780:NP RS01800
gene id: 348780:NP_RS01800
uniprot id: Q3ITT7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

348780:NP RS12440
gene id: 348780:NP_RS12440
uniprot id: A0A1U7EZ84
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

348780:NP RS05035
gene id: 348780:NP_RS05035
uniprot id: A0A1U7EVP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Membrane

348780:NP RS10985
gene id: 348780:NP_RS10985
uniprot id: Q3INI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

348780:NP RS00675
gene id: 348780:NP_RS00675
uniprot id: A0A1U7ETI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

348780:NP RS10900
gene id: 348780:NP_RS10900
uniprot id: Q3INK4
names: Similarity
messages: Belongs to the PDCD5 family.

348780:NP RS12890
gene id: 348780:NP_RS12890
uniprot id: Q3IMF0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

348780:NP RS10220
gene id: 348780:NP_RS10220
uniprot id: A0A1U7EY54
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS07605
gene id: 348780:NP_RS07605
uniprot id: Q3IQG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

348780:NP RS12875
gene id: 348780:NP_RS12875
uniprot id: Q3IMF3
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

348780:NP RS04005
gene id: 348780:NP_RS04005
uniprot id: A0A1U7EV55
names: Similarity
messages: Belongs to the SCO1/2 family.

348780:NP RS04230
gene id: 348780:NP_RS04230
uniprot id: Q3ISE6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

348780:NP RS02085
gene id: 348780:NP_RS02085
uniprot id: A0A1U7EU69
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS11510
gene id: 348780:NP_RS11510
uniprot id: A0A1U7EYU3
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

348780:NP RS09040
gene id: 348780:NP_RS09040
uniprot id: Q3IPM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

348780:NP RS12110
gene id: 348780:NP_RS12110
uniprot id: A0A1U7EZ40
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS09210
gene id: 348780:NP_RS09210
uniprot id: Q3IPJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

348780:NP RS08585
gene id: 348780:NP_RS08585
uniprot id: Q3IPX0
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

348780:NP RS12190
gene id: 348780:NP_RS12190
uniprot id: A0A1U7EZ68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

348780:NP RS01930
gene id: 348780:NP_RS01930
uniprot id: A0A1U7EU54
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

348780:NP RS01110
gene id: 348780:NP_RS01110
uniprot id: Q3IU78
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

348780:NP RS03990
gene id: 348780:NP_RS03990
uniprot id: A0A1U7EV61
names: Subunit
messages: Homotrimer.

348780:NP RS01955
gene id: 348780:NP_RS01955
uniprot id: Q3ITQ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M54 family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.
messages: Monomer.
messages: Probable zinc metalloprotease whose natural substrate is unknown.

348780:NP RS01415
gene id: 348780:NP_RS01415
uniprot id: Q3IU15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

348780:NP RS12050
gene id: 348780:NP_RS12050
uniprot id: A0A1U7EZ46
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

348780:NP RS00995
gene id: 348780:NP_RS00995
uniprot id: Q3IU96
names: Similarity
messages: Belongs to the SUI1 family.

348780:NP RS00190
gene id: 348780:NP_RS00190
uniprot id: A0A1U7ETA7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

348780:NP RS11755
gene id: 348780:NP_RS11755
uniprot id: Q3IN29
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

348780:NP RS01500
gene id: 348780:NP_RS01500
uniprot id: A0A1U7ETW5
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.
messages: Has ATPase and non-specific DNA-binding activities.

348780:NP RS10730
gene id: 348780:NP_RS10730
uniprot id: Q3INN9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

348780:NP RS00255
gene id: 348780:NP_RS00255
uniprot id: A0A1U7ETC5
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS11150
gene id: 348780:NP_RS11150
uniprot id: A0A1U7EYL4
names: Subcellular Location Annotation
messages: Cytoplasm

348780:NP RS01745
gene id: 348780:NP_RS01745
uniprot id: A0A1U7EU18
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

348780:NP RS00710
gene id: 348780:NP_RS00710
uniprot id: Q3IUE8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

348780:NP RS04980
gene id: 348780:NP_RS04980
uniprot id: Q3IRZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

348780:NP RS04425
gene id: 348780:NP_RS04425
uniprot id: A0A1U7EVE0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

348780:NP RS11250
gene id: 348780:NP_RS11250
uniprot id: A0A1U7EYP5
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

348780:NP RS12120
gene id: 348780:NP_RS12120
uniprot id: A0A1U7EZ53
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

348780:NP RS08865
gene id: 348780:NP_RS08865
uniprot id: A0A1U7EXJ9
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

348780:NP RS00140
gene id: 348780:NP_RS00140
uniprot id: A0A1U7ETB1
names: Similarity
messages: Belongs to the NAD synthetase family.

348780:NP RS05040
gene id: 348780:NP_RS05040
uniprot id: A0A1U7EVP1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

348780:NP RS12910
gene id: 348780:NP_RS12910
uniprot id: A0A1U7EZH5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

348780:NP RS12955
gene id: 348780:NP_RS12955
uniprot id: A0A1U7EZK3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family. LysK subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
messages: Cytoplasm

348780:NP RS02480
gene id: 348780:NP_RS02480
uniprot id: Q3ITE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

348780:NP RS11900
gene id: 348780:NP_RS11900
uniprot id: A0A1U7EZ20
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

348780:NP RS10595
gene id: 348780:NP_RS10595
uniprot id: A0A1U7EYC5
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

348780:NP RS00620
gene id: 348780:NP_RS00620
uniprot id: A0A1U7ETI2
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

348780:NP RS09055
gene id: 348780:NP_RS09055
uniprot id: Q3IPM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

348780:NP RS09330
gene id: 348780:NP_RS09330
uniprot id: Q3IPH3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

348780:NP RS12085
gene id: 348780:NP_RS12085
uniprot id: A0A1U7EZ49
names: Function
messages: Part of a potassium transport system.

348780:NP RS11590
gene id: 348780:NP_RS11590
uniprot id: A0A1U7EYX5
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS08605
gene id: 348780:NP_RS08605
uniprot id: Q3IPW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

348780:NP RS07730
gene id: 348780:NP_RS07730
uniprot id: A0A1U7EX00
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

348780:NP RS02130
gene id: 348780:NP_RS02130
uniprot id: A0A1U7EU83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

348780:NP RS10150
gene id: 348780:NP_RS10150
uniprot id: Q3IP08
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

348780:NP RS12330
gene id: 348780:NP_RS12330
uniprot id: A0A1U7EZ64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

348780:NP RS10890
gene id: 348780:NP_RS10890
uniprot id: A0A1U7EYH4
names: Caution
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

348780:NP RS00105
gene id: 348780:NP_RS00105
uniprot id: A0A1U7ET96
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS03480
gene id: 348780:NP_RS03480
uniprot id: A0A1U7EUX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

348780:NP RS02035
gene id: 348780:NP_RS02035
uniprot id: A0A1U7EU71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

348780:NP RS07230
gene id: 348780:NP_RS07230
uniprot id: A0A1U7EWT1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

348780:NP RS11105
gene id: 348780:NP_RS11105
uniprot id: A0A1U7EYN6
names: Similarity
messages: Belongs to the Ahb/Nir family.

348780:NP RS08680
gene id: 348780:NP_RS08680
uniprot id: A0A1U7EXE2
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

348780:NP RS13590
gene id: 348780:NP_RS13590
uniprot id: Q3IM04
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.

348780:NP RS08545
gene id: 348780:NP_RS08545
uniprot id: Q3IPX9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.
messages: Binds 1 FAD per subunit.
messages: May have a photoreceptor function. Binds DNA; probably functions as a transcriptional repressor (By similarity).

348780:NP RS03485
gene id: 348780:NP_RS03485
uniprot id: A0A1U7EUX0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

348780:NP RS05885
gene id: 348780:NP_RS05885
uniprot id: A0A1U7EW37
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

348780:NP RS11175
gene id: 348780:NP_RS11175
uniprot id: A0A1U7EYQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsbB family. BdbC subfamily.
messages: Membrane

348780:NP RS01265
gene id: 348780:NP_RS01265
uniprot id: Q3IU46
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

348780:NP RS12060
gene id: 348780:NP_RS12060
uniprot id: Q3IMW9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

348780:NP RS04430
gene id: 348780:NP_RS04430
uniprot id: A0A1U7EVD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

348780:NP RS08845
gene id: 348780:NP_RS08845
uniprot id: A0A1U7EXI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

348780:NP RS07255
gene id: 348780:NP_RS07255
uniprot id: A0A1U7EWS7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

348780:NP RS07380
gene id: 348780:NP_RS07380
uniprot id: A0A1U7EWV2
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS09250
gene id: 348780:NP_RS09250
uniprot id: A0A1U7EXP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

348780:NP RS10680
gene id: 348780:NP_RS10680
uniprot id: A0A1U7EYF5
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS00650
gene id: 348780:NP_RS00650
uniprot id: Q3IUF9
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

348780:NP RS11965
gene id: 348780:NP_RS11965
uniprot id: Q3IMY8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

348780:NP RS08840
gene id: 348780:NP_RS08840
uniprot id: A0A1U7EXH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

348780:NP RS13650
gene id: 348780:NP_RS13650
uniprot id: Q3ILZ2
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS04970
gene id: 348780:NP_RS04970
uniprot id: Q3IRZ5
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

348780:NP RS05535
gene id: 348780:NP_RS05535
uniprot id: A0A1U7EVX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Membrane

348780:NP RS11595
gene id: 348780:NP_RS11595
uniprot id: A0A1U7EYX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

348780:NP RS06840
gene id: 348780:NP_RS06840
uniprot id: A0A1U7EWL2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

348780:NP RS10655
gene id: 348780:NP_RS10655
uniprot id: Q3INQ6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.

348780:NP RS11820
gene id: 348780:NP_RS11820
uniprot id: A0A1U7EZ16
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

348780:NP RS05705
gene id: 348780:NP_RS05705
uniprot id: A0A1U7EVZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

348780:NP RS09610
gene id: 348780:NP_RS09610
uniprot id: A0A1U7EXX0
names: Similarity
messages: Belongs to the MCM family.

348780:NP RS01170
gene id: 348780:NP_RS01170
uniprot id: A0A1U7ETS4
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

348780:NP RS01260
gene id: 348780:NP_RS01260
uniprot id: A0A1U7ETT5
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

348780:NP RS07940
gene id: 348780:NP_RS07940
uniprot id: Q3IQA3
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

348780:NP RS07080
gene id: 348780:NP_RS07080
uniprot id: A0A1U7EWP3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

348780:NP RS06610
gene id: 348780:NP_RS06610
uniprot id: A0A1U7EWH0
names: Subcellular Location Annotation
messages: Cytoplasm

348780:NP RS07830
gene id: 348780:NP_RS07830
uniprot id: Q3IQC4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

348780:NP RS08575
gene id: 348780:NP_RS08575
uniprot id: A0A1U7EXD2
names: Similarity
messages: Belongs to the UPF0212 family.

348780:NP RS06040
gene id: 348780:NP_RS06040
uniprot id: Q3IRC9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.

348780:NP RS08540
gene id: 348780:NP_RS08540
uniprot id: A0A1U7EXD9
names: Similarity
messages: Belongs to the UPF0047 family.

348780:NP RS05920
gene id: 348780:NP_RS05920
uniprot id: A0A1U7EW29
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

348780:NP RS12920
gene id: 348780:NP_RS12920
uniprot id: Q3IME2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

348780:NP RS04100
gene id: 348780:NP_RS04100
uniprot id: A0A1U7EV81
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

348780:NP RS00020
gene id: 348780:NP_RS00020
uniprot id: A0A1U7ET82
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

348780:NP RS04395
gene id: 348780:NP_RS04395
uniprot id: Q3ISB3
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

348780:NP RS05115
gene id: 348780:NP_RS05115
uniprot id: A0A1U7EVP8
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Probably part of the ribosome quality control system (RQC). May mediate the addition of alanine residues (Ala tailing) to incompletely synthesized nascent chains from stalled ribosomes, leading to their degradation.

348780:NP RS05605
gene id: 348780:NP_RS05605
uniprot id: Q3IRL6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.

348780:NP RS13450
gene id: 348780:NP_RS13450
uniprot id: Q3IM35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

348780:NP RS13440
gene id: 348780:NP_RS13440
uniprot id: Q3IM37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

348780:NP RS04420
gene id: 348780:NP_RS04420
uniprot id: A0A1U7EVE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

348780:NP RS11980
gene id: 348780:NP_RS11980
uniprot id: Q3IMY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

348780:NP RS08260
gene id: 348780:NP_RS08260
uniprot id: Q3IQ37
names: Similarity
messages: Belongs to the TrpF family.

348780:NP RS09885
gene id: 348780:NP_RS09885
uniprot id: A0A1U7EY17
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

348780:NP RS13080
gene id: 348780:NP_RS13080
uniprot id: A0A1U7EZM0
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

348780:NP RS10815
gene id: 348780:NP_RS10815
uniprot id: A0A1U7EYH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

348780:NP RS10980
gene id: 348780:NP_RS10980
uniprot id: Q3INI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

348780:NP RS01595
gene id: 348780:NP_RS01595
uniprot id: A0A1U7ETY9
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

348780:NP RS06455
gene id: 348780:NP_RS06455
uniprot id: A0A1U7EWE0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

348780:NP RS13495
gene id: 348780:NP_RS13495
uniprot id: Q3IM26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

348780:NP RS12775
gene id: 348780:NP_RS12775
uniprot id: A0A1U7EZG9
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

348780:NP RS01920
gene id: 348780:NP_RS01920
uniprot id: A0A1U7EU50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

348780:NP RS00215
gene id: 348780:NP_RS00215
uniprot id: A0A1U7ETC3
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

348780:NP RS03365
gene id: 348780:NP_RS03365
uniprot id: A0A1U7EUV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

348780:NP RS05730
gene id: 348780:NP_RS05730
uniprot id: A0A1U7EW07
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

348780:NP RS01585
gene id: 348780:NP_RS01585
uniprot id: Q3ITY2
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

348780:NP RS05670
gene id: 348780:NP_RS05670
uniprot id: A0A1U7EW03
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS04865
gene id: 348780:NP_RS04865
uniprot id: Q3IS17
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

348780:NP RS02090
gene id: 348780:NP_RS02090
uniprot id: A0A1U7EU81
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS06235
gene id: 348780:NP_RS06235
uniprot id: A0A1U7EWB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

348780:NP RS04905
gene id: 348780:NP_RS04905
uniprot id: A0A1U7EVL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

348780:NP RS02580
gene id: 348780:NP_RS02580
uniprot id: Q3ITC8
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

348780:NP RS02605
gene id: 348780:NP_RS02605
uniprot id: A0A1U7EUH4
names: Similarity
messages: Belongs to the MoaB/Mog family.

348780:NP RS01735
gene id: 348780:NP_RS01735
uniprot id: A0A1U7EU24
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

348780:NP RS12620
gene id: 348780:NP_RS12620
uniprot id: Q3IMK4
names: Caution
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

348780:NP RS07270
gene id: 348780:NP_RS07270
uniprot id: A0A1U7EWT2
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

348780:NP RS03760
gene id: 348780:NP_RS03760
uniprot id: A0A1U7EV12
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

348780:NP RS09840
gene id: 348780:NP_RS09840
uniprot id: A0A1U7EY02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

348780:NP RS07025
gene id: 348780:NP_RS07025
uniprot id: Q3IQT2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

348780:NP RS02565
gene id: 348780:NP_RS02565
uniprot id: Q3ITD1
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

348780:NP RS04310
gene id: 348780:NP_RS04310
uniprot id: Q3ISC9
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

348780:NP RS00905
gene id: 348780:NP_RS00905
uniprot id: Q3IUB3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

348780:NP RS12600
gene id: 348780:NP_RS12600
uniprot id: Q3IMK8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

348780:NP RS10210
gene id: 348780:NP_RS10210
uniprot id: Q3INZ6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

348780:NP RS11875
gene id: 348780:NP_RS11875
uniprot id: A0A1U7EZ27
names: Similarity
messages: Belongs to the PrpD family.

348780:NP RS04740
gene id: 348780:NP_RS04740
uniprot id: A0A1U7EVI2
names: Similarity
messages: Belongs to the TPP enzyme family.

348780:NP RS11990
gene id: 348780:NP_RS11990
uniprot id: Q3IMY3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

348780:NP RS09110
gene id: 348780:NP_RS09110
uniprot id: A0A1U7EXL4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

348780:NP RS01730
gene id: 348780:NP_RS01730
uniprot id: A0A1U7EU26
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.

348780:NP RS08005
gene id: 348780:NP_RS08005
uniprot id: Q3IQ90
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

348780:NP RS03645
gene id: 348780:NP_RS03645
uniprot id: Q3ISR6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

348780:NP RS05620
gene id: 348780:NP_RS05620
uniprot id: A0A1U7EVZ2
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS12885
gene id: 348780:NP_RS12885
uniprot id: Q3IMF1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

348780:NP RS09440
gene id: 348780:NP_RS09440
uniprot id: A0A1U7EXS6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

348780:NP RS04400
gene id: 348780:NP_RS04400
uniprot id: Q3ISB2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.
messages: Unlike some other archaeal S14P proteins, this is unable to bind zinc.

348780:NP RS03310
gene id: 348780:NP_RS03310
uniprot id: A0A1U7EUV4
names: Similarity
messages: Belongs to the HMBS family.

348780:NP RS08365
gene id: 348780:NP_RS08365
uniprot id: A0A1U7EX76
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

348780:NP RS04680
gene id: 348780:NP_RS04680
uniprot id: Q3IS55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

348780:NP RS04825
gene id: 348780:NP_RS04825
uniprot id: A0A1U7EVL1
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS10695
gene id: 348780:NP_RS10695
uniprot id: A0A1U7EYE3
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

348780:NP RS04645
gene id: 348780:NP_RS04645
uniprot id: A0A1U7EVH6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

348780:NP RS10825
gene id: 348780:NP_RS10825
uniprot id: A0A1U7EYH0
names: Similarity
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.

348780:NP RS00610
gene id: 348780:NP_RS00610
uniprot id: A0A1U7ETI0
names: Similarity
messages: Belongs to the HypE family.

348780:NP RS08275
gene id: 348780:NP_RS08275
uniprot id: A0A1U7EX89
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

348780:NP RS02225
gene id: 348780:NP_RS02225
uniprot id: A0A1U7EUA4
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

348780:NP RS02665
gene id: 348780:NP_RS02665
uniprot id: Q3ITB1
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

348780:NP RS02585
gene id: 348780:NP_RS02585
uniprot id: Q3ITC7
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

348780:NP RS06405
gene id: 348780:NP_RS06405
uniprot id: Q3IR53
names: Similarity
messages: Belongs to the UPF0145 family.

348780:NP RS12415
gene id: 348780:NP_RS12415
uniprot id: Q3IMP6
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.

348780:NP RS12495
gene id: 348780:NP_RS12495
uniprot id: Q3IMM9
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

348780:NP RS07440
gene id: 348780:NP_RS07440
uniprot id: A0A1U7EWY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Membrane

348780:NP RS03035
gene id: 348780:NP_RS03035
uniprot id: A0A1U7EUN8
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

348780:NP RS09990
gene id: 348780:NP_RS09990
uniprot id: A0A1U7EY38
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

348780:NP RS07225
gene id: 348780:NP_RS07225
uniprot id: A0A1U7EWR6
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

348780:NP RS04110
gene id: 348780:NP_RS04110
uniprot id: A0A1U7EV83
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

348780:NP RS04945
gene id: 348780:NP_RS04945
uniprot id: A0A1U7EVM9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

348780:NP RS10415
gene id: 348780:NP_RS10415
uniprot id: Q3INV7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

348780:NP RS05420
gene id: 348780:NP_RS05420
uniprot id: Q3IRQ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

348780:NP RS01420
gene id: 348780:NP_RS01420
uniprot id: A0A1U7ETW6
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

348780:NP RS00780
gene id: 348780:NP_RS00780
uniprot id: Q3IUD6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Catalyzes the NAD-dependent oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
messages: Homodimer.

348780:NP RS06045
gene id: 348780:NP_RS06045
uniprot id: A0A1U7EW54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Membrane

348780:NP RS07825
gene id: 348780:NP_RS07825
uniprot id: A0A1U7EX33
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

348780:NP RS12935
gene id: 348780:NP_RS12935
uniprot id: Q3IMD9
names: Similarity
messages: Belongs to the RimK family. LysX subfamily.

348780:NP RS03525
gene id: 348780:NP_RS03525
uniprot id: A0A1U7EUX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

348780:NP RS00100
gene id: 348780:NP_RS00100
uniprot id: Q3IUS0
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

348780:NP RS02575
gene id: 348780:NP_RS02575
uniprot id: A0A1U7EUF2
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

348780:NP RS09130
gene id: 348780:NP_RS09130
uniprot id: Q3IPL0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

348780:NP RS01880
gene id: 348780:NP_RS01880
uniprot id: Q3ITS0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

348780:NP RS04780
gene id: 348780:NP_RS04780
uniprot id: A0A1U7EVJ8
names: Similarity
messages: Belongs to the CDP-glycerol glycerophosphotransferase family.

348780:NP RS12080
gene id: 348780:NP_RS12080
uniprot id: A0A1U7EZ47
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

348780:NP RS10025
gene id: 348780:NP_RS10025
uniprot id: Q3IP34
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

348780:NP RS11915
gene id: 348780:NP_RS11915
uniprot id: A0A1U7EZ17
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.

348780:NP RS11970
gene id: 348780:NP_RS11970
uniprot id: Q3IMY7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

348780:NP RS11995
gene id: 348780:NP_RS11995
uniprot id: Q3IMY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

348780:NP RS01475
gene id: 348780:NP_RS01475
uniprot id: Q3IU04
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

348780:NP RS04950
gene id: 348780:NP_RS04950
uniprot id: A0A1U7EVM6
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS01045
gene id: 348780:NP_RS01045
uniprot id: A0A1U7ETP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

348780:NP RS13615
gene id: 348780:NP_RS13615
uniprot id: Q3ILZ9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

348780:NP RS09995
gene id: 348780:NP_RS09995
uniprot id: A0A1U7EY18
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase family.
messages: Binds 1 FAD per subunit.

348780:NP RS15025
gene id: 348780:NP_RS15025
uniprot id: Q3ILZ1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

348780:NP RS11050
gene id: 348780:NP_RS11050
uniprot id: A0A1U7EYM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

348780:NP RS03135
gene id: 348780:NP_RS03135
uniprot id: A0A1U7EUR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

348780:NP RS05600
gene id: 348780:NP_RS05600
uniprot id: Q3IRL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

348780:NP RS10225
gene id: 348780:NP_RS10225
uniprot id: A0A1U7EY72
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

348780:NP RS13400
gene id: 348780:NP_RS13400
uniprot id: Q3IM45
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS07000
gene id: 348780:NP_RS07000
uniprot id: Q3IQT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

348780:NP RS00705
gene id: 348780:NP_RS00705
uniprot id: A0A1U7ETK3
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

348780:NP RS04275
gene id: 348780:NP_RS04275
uniprot id: A0A1U7EVA1
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

348780:NP RS03795
gene id: 348780:NP_RS03795
uniprot id: A0A1U7EV18
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

348780:NP RS11035
gene id: 348780:NP_RS11035
uniprot id: Q3INH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

348780:NP RS00560
gene id: 348780:NP_RS00560
uniprot id: A0A1U7ETH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

348780:NP RS03175
gene id: 348780:NP_RS03175
uniprot id: A0A1U7EUQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

348780:NP RS00530
gene id: 348780:NP_RS00530
uniprot id: A0A1U7ETH5
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

348780:NP RS00770
gene id: 348780:NP_RS00770
uniprot id: Q3IUD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

348780:NP RS09245
gene id: 348780:NP_RS09245
uniprot id: A0A1U7EXN8
names: Similarity
messages: Belongs to the SDO1/SBDS family.

348780:NP RS01945
gene id: 348780:NP_RS01945
uniprot id: A0A1U7EU51
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

348780:NP RS10710
gene id: 348780:NP_RS10710
uniprot id: Q3INP4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

348780:NP RS12750
gene id: 348780:NP_RS12750
uniprot id: Q3IMI0
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: During the catalytic reaction, a sulfide is transferred from Cys-166 to a reaction intermediate, generating a dehydroalanine residue.
messages: Homooctamer; tetramer of dimers.
messages: Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.

348780:NP RS10380
gene id: 348780:NP_RS10380
uniprot id: A0A1U7EYA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

348780:NP RS03150
gene id: 348780:NP_RS03150
uniprot id: Q3IT14
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

348780:NP RS07920
gene id: 348780:NP_RS07920
uniprot id: A0A1U7EX45
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS07515
gene id: 348780:NP_RS07515
uniprot id: Q3IQI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

348780:NP RS00080
gene id: 348780:NP_RS00080
uniprot id: A0A1U7ETA2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

348780:NP RS12945
gene id: 348780:NP_RS12945
uniprot id: A0A1U7EZH4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. LysZ subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

348780:NP RS11490
gene id: 348780:NP_RS11490
uniprot id: A0A1U7EYV7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

348780:NP RS08955
gene id: 348780:NP_RS08955
uniprot id: A0A1U7EXJ8
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS08700
gene id: 348780:NP_RS08700
uniprot id: Q3IPU7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

348780:NP RS11420
gene id: 348780:NP_RS11420
uniprot id: A0A1U7EYR7
names: Similarity
messages: Belongs to the peptidase S8 family.

348780:NP RS09315
gene id: 348780:NP_RS09315
uniprot id: Q3IPH6
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

348780:NP RS08670
gene id: 348780:NP_RS08670
uniprot id: A0A1U7EXF9
names: Subcellular Location Annotation
messages: Cytoplasm

348780:NP RS02100
gene id: 348780:NP_RS02100
uniprot id: A0A1U7EU84
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

348780:NP RS11770
gene id: 348780:NP_RS11770
uniprot id: A0A1U7EZ09
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS05655
gene id: 348780:NP_RS05655
uniprot id: A0A1U7EVY6
names: Similarity
messages: Belongs to the complex I subunit 3 family.

348780:NP RS07660
gene id: 348780:NP_RS07660
uniprot id: Q3IQF5
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

348780:NP RS05205
gene id: 348780:NP_RS05205
uniprot id: Q3IRU8
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

348780:NP RS10350
gene id: 348780:NP_RS10350
uniprot id: A0A1U7EY92
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

348780:NP RS03330
gene id: 348780:NP_RS03330
uniprot id: A0A1U7EUU8
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

348780:NP RS05265
gene id: 348780:NP_RS05265
uniprot id: Q3IRT5
names: Similarity
messages: Belongs to the UPF0173 family.

348780:NP RS13030
gene id: 348780:NP_RS13030
uniprot id: A0A1U7EZK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal/bacterial/fungal opsin family.
messages: Membrane

348780:NP RS06190
gene id: 348780:NP_RS06190
uniprot id: A0A1U7EW92
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

348780:NP RS03815
gene id: 348780:NP_RS03815
uniprot id: A0A1U7EV22
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

348780:NP RS10660
gene id: 348780:NP_RS10660
uniprot id: A0A1U7EYD9
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

348780:NP RS06025
gene id: 348780:NP_RS06025
uniprot id: A0A1U7EW62
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS00920
gene id: 348780:NP_RS00920
uniprot id: Q3IUB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).

348780:NP RS03055
gene id: 348780:NP_RS03055
uniprot id: Q3IT33
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

348780:NP RS00715
gene id: 348780:NP_RS00715
uniprot id: A0A1U7ETJ8
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

348780:NP RS04445
gene id: 348780:NP_RS04445
uniprot id: A0A1U7EVD9
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

348780:NP RS12005
gene id: 348780:NP_RS12005
uniprot id: A0A1U7EZ14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

348780:NP RS10070
gene id: 348780:NP_RS10070
uniprot id: A0A1U7EY41
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

348780:NP RS09100
gene id: 348780:NP_RS09100
uniprot id: Q3IPL7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

348780:NP RS08770
gene id: 348780:NP_RS08770
uniprot id: A0A1U7EXF6
names: Similarity
messages: Belongs to the HypE family.

348780:NP RS03715
gene id: 348780:NP_RS03715
uniprot id: A0A1U7EV06
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

348780:NP RS11710
gene id: 348780:NP_RS11710
uniprot id: A0A1U7EZM7
names: Similarity
messages: Belongs to the arginase family.

348780:NP RS05955
gene id: 348780:NP_RS05955
uniprot id: A0A1U7EW51
names: Similarity
messages: Belongs to the PspA/IM30 family.

348780:NP RS01725
gene id: 348780:NP_RS01725
uniprot id: A0A1U7EU09
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

348780:NP RS01065
gene id: 348780:NP_RS01065
uniprot id: Q3IU82
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

348780:NP RS04040
gene id: 348780:NP_RS04040
uniprot id: A0A1U7EV87
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

348780:NP RS00765
gene id: 348780:NP_RS00765
uniprot id: Q3IUD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

348780:NP RS12450
gene id: 348780:NP_RS12450
uniprot id: Q3IMN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the inorganic carbon transporter (TC 9.A.2) DabA family.
messages: Cell membrane
messages: Forms a complex with DabB.
messages: Part of an energy-coupled inorganic carbon pump.

348780:NP RS04940
gene id: 348780:NP_RS04940
uniprot id: A0A1U7EVN2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

348780:NP RS07650
gene id: 348780:NP_RS07650
uniprot id: A0A1U7EWZ3
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

348780:NP RS08580
gene id: 348780:NP_RS08580
uniprot id: Q3IPX1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

348780:NP RS05880
gene id: 348780:NP_RS05880
uniprot id: A0A1U7EW41
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS04410
gene id: 348780:NP_RS04410
uniprot id: A0A1U7EVD8
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

348780:NP RS12300
gene id: 348780:NP_RS12300
uniprot id: Q3IMS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

348780:NP RS13540
gene id: 348780:NP_RS13540
uniprot id: Q3IM17
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

348780:NP RS06935
gene id: 348780:NP_RS06935
uniprot id: Q3IQU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

348780:NP RS00630
gene id: 348780:NP_RS00630
uniprot id: Q3IUG3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

348780:NP RS09715
gene id: 348780:NP_RS09715
uniprot id: A0A1U7EXZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

348780:NP RS06995
gene id: 348780:NP_RS06995
uniprot id: Q3IQT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

348780:NP RS06355
gene id: 348780:NP_RS06355
uniprot id: A0A1U7EWC0
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

348780:NP RS01980
gene id: 348780:NP_RS01980
uniprot id: Q3ITP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

348780:NP RS08600
gene id: 348780:NP_RS08600
uniprot id: Q3IPW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

348780:NP RS00295
gene id: 348780:NP_RS00295
uniprot id: A0A1U7ETC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

348780:NP RS06210
gene id: 348780:NP_RS06210
uniprot id: Q3IR95
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

348780:NP RS02530
gene id: 348780:NP_RS02530
uniprot id: Q3ITD8
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

348780:NP RS05280
gene id: 348780:NP_RS05280
uniprot id: Q3IRT2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

348780:NP RS10485
gene id: 348780:NP_RS10485
uniprot id: Q3INU3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

348780:NP RS00725
gene id: 348780:NP_RS00725
uniprot id: Q3IUE5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

348780:NP RS05290
gene id: 348780:NP_RS05290
uniprot id: Q3IRT0
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

348780:NP RS01885
gene id: 348780:NP_RS01885
uniprot id: A0A1U7EU38
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS00800
gene id: 348780:NP_RS00800
uniprot id: A0A1U7ETK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

348780:NP RS09235
gene id: 348780:NP_RS09235
uniprot id: Q3IPJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

348780:NP RS05710
gene id: 348780:NP_RS05710
uniprot id: A0A1U7EW04
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS11090
gene id: 348780:NP_RS11090
uniprot id: Q3ING6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

348780:NP RS03980
gene id: 348780:NP_RS03980
uniprot id: Q3ISJ8
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

348780:NP RS12420
gene id: 348780:NP_RS12420
uniprot id: Q3IMP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

348780:NP RS11305
gene id: 348780:NP_RS11305
uniprot id: A0A1U7EYQ5
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

348780:NP RS05160
gene id: 348780:NP_RS05160
uniprot id: A0A1U7EVR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

348780:NP RS02025
gene id: 348780:NP_RS02025
uniprot id: Q3ITN9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

348780:NP RS09035
gene id: 348780:NP_RS09035
uniprot id: A0A1U7EXK6
names: Similarity
messages: Belongs to the Dps family.

348780:NP RS05960
gene id: 348780:NP_RS05960
uniprot id: A0A1U7EW47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

348780:NP RS00460
gene id: 348780:NP_RS00460
uniprot id: Q3IUJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

348780:NP RS07220
gene id: 348780:NP_RS07220
uniprot id: A0A1U7EWR0
names: Function
messages: Part of a potassium transport system.

348780:NP RS00260
gene id: 348780:NP_RS00260
uniprot id: A0A1U7ETB7
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: The active site is a redox-active disulfide bond.

348780:NP RS05950
gene id: 348780:NP_RS05950
uniprot id: Q3IRE7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.

348780:NP RS05695
gene id: 348780:NP_RS05695
uniprot id: A0A1U7EW01
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS07050
gene id: 348780:NP_RS07050
uniprot id: A0A1U7EWN0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the phosphorylation of isopentenyl phosphate (IP) to isopentenyl diphosphate (IPP). Functions in an alternate mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Homodimer.

348780:NP RS12155
gene id: 348780:NP_RS12155
uniprot id: A0A1U7EZ31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the beta-RFA-P synthase family.
messages: Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
messages: Homodimer.

348780:NP RS02030
gene id: 348780:NP_RS02030
uniprot id: Q3ITN8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

348780:NP RS09770
gene id: 348780:NP_RS09770
uniprot id: A0A1U7EXX7
names: Cofactor
messages: Binds 1 copper ion per subunit.

348780:NP RS01160
gene id: 348780:NP_RS01160
uniprot id: A0A1U7ETR0
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.

348780:NP RS06475
gene id: 348780:NP_RS06475
uniprot id: A0A1U7EWD6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

348780:NP RS10975
gene id: 348780:NP_RS10975
uniprot id: A0A1U7EYL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

348780:NP RS11890
gene id: 348780:NP_RS11890
uniprot id: A0A1U7EZ24
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.

348780:NP RS06265
gene id: 348780:NP_RS06265
uniprot id: A0A1U7EWA2
names: Similarity
messages: Belongs to the cytochrome P450 family.

348780:NP RS00785
gene id: 348780:NP_RS00785
uniprot id: A0A1U7ETK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

348780:NP RS03675
gene id: 348780:NP_RS03675
uniprot id: A0A1U7EUZ5
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS10020
gene id: 348780:NP_RS10020
uniprot id: Q3IP35
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

348780:NP RS11685
gene id: 348780:NP_RS11685
uniprot id: A0A1U7EYZ4
names: Cofactor
messages: Binds 1 copper ion per subunit.

348780:NP RS02595
gene id: 348780:NP_RS02595
uniprot id: A0A1U7EUG0
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

348780:NP RS07110
gene id: 348780:NP_RS07110
uniprot id: Q3IQR5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

348780:NP RS01445
gene id: 348780:NP_RS01445
uniprot id: Q3IU09
names: Similarity
messages: Belongs to the RutC family.

348780:NP RS11100
gene id: 348780:NP_RS11100
uniprot id: A0A1U7EYL9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

348780:NP RS01565
gene id: 348780:NP_RS01565
uniprot id: Q3ITY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

348780:NP RS09465
gene id: 348780:NP_RS09465
uniprot id: A0A1U7EXT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

348780:NP RS13725
gene id: 348780:NP_RS13725
uniprot id: Q3ILX7
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

348780:NP RS06120
gene id: 348780:NP_RS06120
uniprot id: A0A1U7EW78
names: Similarity
messages: Belongs to the mandelate racemase/muconate lactonizing enzyme family.

348780:NP RS13395
gene id: 348780:NP_RS13395
uniprot id: Q3IM46
names: Similarity
messages: Belongs to the SELO family.

348780:NP RS01975
gene id: 348780:NP_RS01975
uniprot id: A0A1U7EU61
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS00930
gene id: 348780:NP_RS00930
uniprot id: A0A1U7ETM6
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

348780:NP RS13680
gene id: 348780:NP_RS13680
uniprot id: Q3ILY6
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

348780:NP RS13610
gene id: 348780:NP_RS13610
uniprot id: Q3IM00
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

348780:NP RS09085
gene id: 348780:NP_RS09085
uniprot id: Q3IPM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

348780:NP RS07930
gene id: 348780:NP_RS07930
uniprot id: Q3IQA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

348780:NP RS09355
gene id: 348780:NP_RS09355
uniprot id: Q3IPG8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

348780:NP RS10990
gene id: 348780:NP_RS10990
uniprot id: Q3INI5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

348780:NP RS10645
gene id: 348780:NP_RS10645
uniprot id: A0A1U7EYF0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

348780:NP RS03155
gene id: 348780:NP_RS03155
uniprot id: A0A1U7EUQ5
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

348780:NP RS09470
gene id: 348780:NP_RS09470
uniprot id: A0A1U7EXR5
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

348780:NP RS00330
gene id: 348780:NP_RS00330
uniprot id: A0A1U7ETD8
names: Similarity
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the malic enzymes family.

348780:NP RS09705
gene id: 348780:NP_RS09705
uniprot id: A0A1U7EXY7
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS06065
gene id: 348780:NP_RS06065
uniprot id: A0A1U7EW67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

348780:NP RS13365
gene id: 348780:NP_RS13365
uniprot id: Q3IM53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

348780:NP RS04710
gene id: 348780:NP_RS04710
uniprot id: A0A1U7EVI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

348780:NP RS03280
gene id: 348780:NP_RS03280
uniprot id: A0A1U7EUS1
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

348780:NP RS10290
gene id: 348780:NP_RS10290
uniprot id: Q3INY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

348780:NP RS01215
gene id: 348780:NP_RS01215
uniprot id: Q3IU57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

348780:NP RS00940
gene id: 348780:NP_RS00940
uniprot id: A0A1U7ETN0
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

348780:NP RS12235
gene id: 348780:NP_RS12235
uniprot id: A0A1U7EZ79
names: Similarity
messages: Belongs to the AOR/FOR family.

348780:NP RS04185
gene id: 348780:NP_RS04185
uniprot id: A0A1U7EVA6
names: Similarity
messages: Belongs to the peptidase S8 family.

348780:NP RS04045
gene id: 348780:NP_RS04045
uniprot id: A0A1U7EV78
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

348780:NP RS11115
gene id: 348780:NP_RS11115
uniprot id: Q3ING1
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

348780:NP RS11780
gene id: 348780:NP_RS11780
uniprot id: A0A1U7EYY1
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

348780:NP RS06075
gene id: 348780:NP_RS06075
uniprot id: A0A1U7EW72
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS07880
gene id: 348780:NP_RS07880
uniprot id: A0A1U7EX41
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

348780:NP RS12065
gene id: 348780:NP_RS12065
uniprot id: Q3IMW8
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

348780:NP RS09780
gene id: 348780:NP_RS09780
uniprot id: Q3IP82
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

348780:NP RS05430
gene id: 348780:NP_RS05430
uniprot id: Q3IRQ2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.

348780:NP RS03550
gene id: 348780:NP_RS03550
uniprot id: A0A1U7EUY5
names: Similarity
messages: Belongs to the truncated hemoglobin family. Group I subfamily.

348780:NP RS00660
gene id: 348780:NP_RS00660
uniprot id: Q3IUF7
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

348780:NP RS03010
gene id: 348780:NP_RS03010
uniprot id: A0A1U7EUQ4
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS00445
gene id: 348780:NP_RS00445
uniprot id: A0A1U7ETG1
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.

348780:NP RS07035
gene id: 348780:NP_RS07035
uniprot id: Q3IQT0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

348780:NP RS06230
gene id: 348780:NP_RS06230
uniprot id: A0A1U7EW94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

348780:NP RS04030
gene id: 348780:NP_RS04030
uniprot id: Q3ISI8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

348780:NP RS02975
gene id: 348780:NP_RS02975
uniprot id: A0A1U7EUM7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

348780:NP RS13445
gene id: 348780:NP_RS13445
uniprot id: Q3IM36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
messages: Cell membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

348780:NP RS04135
gene id: 348780:NP_RS04135
uniprot id: A0A1U7EV84
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

348780:NP RS03640
gene id: 348780:NP_RS03640
uniprot id: A0A1U7EUZ1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

348780:NP RS07020
gene id: 348780:NP_RS07020
uniprot id: A0A1U7EWN9
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

348780:NP RS10015
gene id: 348780:NP_RS10015
uniprot id: A0A1U7EY33
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

348780:NP RS02120
gene id: 348780:NP_RS02120
uniprot id: A0A1U7EU77
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

348780:NP RS02625
gene id: 348780:NP_RS02625
uniprot id: A0A1U7EUG8
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

348780:NP RS12015
gene id: 348780:NP_RS12015
uniprot id: Q3IMX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

348780:NP RS11945
gene id: 348780:NP_RS11945
uniprot id: A0A1U7EZ26
names: Similarity
messages: Belongs to the UPF0045 family.

348780:NP RS00235
gene id: 348780:NP_RS00235
uniprot id: Q3IUP2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

348780:NP RS00210
gene id: 348780:NP_RS00210
uniprot id: Q3IUP8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

348780:NP RS05630
gene id: 348780:NP_RS05630
uniprot id: A0A1U7EVY9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

348780:NP RS02285
gene id: 348780:NP_RS02285
uniprot id: A0A1U7EUB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

348780:NP RS03270
gene id: 348780:NP_RS03270
uniprot id: A0A1U7EUS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.
messages: Membrane

348780:NP RS11480
gene id: 348780:NP_RS11480
uniprot id: A0A1U7EYT9
names: Similarity
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

348780:NP RS09560
gene id: 348780:NP_RS09560
uniprot id: A0A1U7EXW0
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

348780:NP RS04990
gene id: 348780:NP_RS04990
uniprot id: Q3IRZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UreE family.
messages: Cytoplasm
messages: Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.

348780:NP RS01505
gene id: 348780:NP_RS01505
uniprot id: A0A1U7ETW8
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

348780:NP RS02700
gene id: 348780:NP_RS02700
uniprot id: A0A1U7EUI0
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

348780:NP RS03315
gene id: 348780:NP_RS03315
uniprot id: A0A1U7EUU9
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

348780:NP RS02810
gene id: 348780:NP_RS02810
uniprot id: A0A1U7EUK7
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

348780:NP RS00485
gene id: 348780:NP_RS00485
uniprot id: Q3IUJ2
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

348780:NP RS09065
gene id: 348780:NP_RS09065
uniprot id: A0A1U7EXM9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal MetE family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown.

348780:NP RS08420
gene id: 348780:NP_RS08420
uniprot id: Q3IQ04
names: Similarity
messages: Belongs to the UPF0179 family.

348780:NP RS05480
gene id: 348780:NP_RS05480
uniprot id: A0A1U7EVV8
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

348780:NP RS02210
gene id: 348780:NP_RS02210
uniprot id: A0A1U7EUA0
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

348780:NP RS09265
gene id: 348780:NP_RS09265
uniprot id: A0A1U7EXM3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

348780:NP RS03065
gene id: 348780:NP_RS03065
uniprot id: Q3IT31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group I subfamily.
messages: Cytoplasm
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

348780:NP RS03415
gene id: 348780:NP_RS03415
uniprot id: Q3ISW0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

348780:NP RS01895
gene id: 348780:NP_RS01895
uniprot id: Q3ITR7
names: Function
names: Similarity
messages: Belongs to the FAU-1 family.
messages: Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.

348780:NP RS08475
gene id: 348780:NP_RS08475
uniprot id: A0A1U7EX97
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS07425
gene id: 348780:NP_RS07425
uniprot id: A0A1U7EWW2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

348780:NP RS00515
gene id: 348780:NP_RS00515
uniprot id: A0A1U7ETG8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Brp/Blh beta-carotene diooxygenase family.
messages: Catalyzes the cleavage of beta-carotene at its central double bond (15,15') to yield two molecules of all-trans-retinal.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

348780:NP RS09015
gene id: 348780:NP_RS09015
uniprot id: A0A1U7EXK8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

348780:NP RS02005
gene id: 348780:NP_RS02005
uniprot id: A0A1U7EU78
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

348780:NP RS11715
gene id: 348780:NP_RS11715
uniprot id: Q3IN37
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

348780:NP RS00290
gene id: 348780:NP_RS00290
uniprot id: A0A1U7ETD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

348780:NP RS11705
gene id: 348780:NP_RS11705
uniprot id: Q3IN38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

348780:NP RS03170
gene id: 348780:NP_RS03170
uniprot id: Q3IT10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

348780:NP RS05820
gene id: 348780:NP_RS05820
uniprot id: A0A1U7EW25
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

348780:NP RS08675
gene id: 348780:NP_RS08675
uniprot id: A0A1U7EXF8
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

348780:NP RS03075
gene id: 348780:NP_RS03075
uniprot id: A0A1U7EUQ0
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

348780:NP RS02280
gene id: 348780:NP_RS02280
uniprot id: A0A1U7EUB4
names: Similarity
messages: Belongs to the SAM hydrolase / SAM-dependent halogenase family.

348780:NP RS12400
gene id: 348780:NP_RS12400
uniprot id: A0A1U7EZA9
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

348780:NP RS12090
gene id: 348780:NP_RS12090
uniprot id: A0A1U7EZ22
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS01100
gene id: 348780:NP_RS01100
uniprot id: A0A1U7ETQ1
names: Function
messages: Protects DNA against thermal denaturation and modulates transcription.

348780:NP RS05935
gene id: 348780:NP_RS05935
uniprot id: Q3IRF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

348780:NP RS04435
gene id: 348780:NP_RS04435
uniprot id: Q3ISA5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

348780:NP RS00185
gene id: 348780:NP_RS00185
uniprot id: Q3IUQ3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).

348780:NP RS11195
gene id: 348780:NP_RS11195
uniprot id: A0A1U7EYN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

348780:NP RS04875
gene id: 348780:NP_RS04875
uniprot id: Q3IS15
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

348780:NP RS03430
gene id: 348780:NP_RS03430
uniprot id: A0A1U7EUW0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

348780:NP RS01645
gene id: 348780:NP_RS01645
uniprot id: A0A1U7ETZ7
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS03985
gene id: 348780:NP_RS03985
uniprot id: A0A1U7EV68
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

348780:NP RS11835
gene id: 348780:NP_RS11835
uniprot id: A0A1U7EZ13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

348780:NP RS00465
gene id: 348780:NP_RS00465
uniprot id: Q3IUJ6
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

348780:NP RS01275
gene id: 348780:NP_RS01275
uniprot id: Q3IU43
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

348780:NP RS03285
gene id: 348780:NP_RS03285
uniprot id: Q3ISY7
names: Similarity
messages: Belongs to the citrate synthase family.

348780:NP RS02220
gene id: 348780:NP_RS02220
uniprot id: Q3ITK1
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

348780:NP RS12730
gene id: 348780:NP_RS12730
uniprot id: Q3IMI4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.

348780:NP RS03975
gene id: 348780:NP_RS03975
uniprot id: Q3ISJ9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.

348780:NP RS09515
gene id: 348780:NP_RS09515
uniprot id: A0A1U7EXU8
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

348780:NP RS10480
gene id: 348780:NP_RS10480
uniprot id: A0A1U7EYA0
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A 'suicide' enzyme that participates in biotin synthesis. Catalyzes the formation of (S)-8-amino-7-oxononanoate (DAN-carbamic acid) from (7R,8S)-8-amino-7-(carboxyamino)nonanoate (DAN), a function equivalent to the cannonical BioA reaction and the first half-reaction of BioD. The cellular requirement for biotin is thought be low enough that this single turnover enzyme supplies a sufficient amount of the cofactor. Overall it catalyzes three reactions: formation of a covalent linkage with 8-amino-7-oxononanoate to yield a BioU-DAN conjugate at the epsilon-amino group of Lys124 of BioU using NAD(P)H, carboxylation of the conjugate to form BioU-DAN-carbamic acid, and release of DAN-carbamic acid using NAD(P)+.
messages: Belongs to the BioU family.
messages: In cannonical biotin synthesis a pimeloyl-conjugate is transformed into biotin by the subsequent action of BioF, BioA, BioD and BioB. This enzyme replaces BioA and performs the first half-reaction of BioD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

348780:NP RS05075
gene id: 348780:NP_RS05075
uniprot id: A0A1U7EVQ2
names: Subcellular Location Annotation
messages: Cytoplasm

348780:NP RS12175
gene id: 348780:NP_RS12175
uniprot id: A0A1U7EZ63
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

348780:NP RS10870
gene id: 348780:NP_RS10870
uniprot id: A0A1U7EYI0
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS03745
gene id: 348780:NP_RS03745
uniprot id: A0A1U7EV08
names: Similarity
messages: Belongs to the DtxR/MntR family.

348780:NP RS03145
gene id: 348780:NP_RS03145
uniprot id: Q3IT15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

348780:NP RS07845
gene id: 348780:NP_RS07845
uniprot id: A0A1U7EX37
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

348780:NP RS03660
gene id: 348780:NP_RS03660
uniprot id: A0A1U7EV02
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

348780:NP RS06000
gene id: 348780:NP_RS06000
uniprot id: A0A1U7EW76
names: Cofactor
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

348780:NP RS05925
gene id: 348780:NP_RS05925
uniprot id: Q3IRF2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

348780:NP RS04975
gene id: 348780:NP_RS04975
uniprot id: Q3IRZ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

348780:NP RS06970
gene id: 348780:NP_RS06970
uniprot id: A0A1U7EWP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

348780:NP RS04325
gene id: 348780:NP_RS04325
uniprot id: Q3ISC7
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

348780:NP RS02370
gene id: 348780:NP_RS02370
uniprot id: A0A1U7EUC8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

348780:NP RS04935
gene id: 348780:NP_RS04935
uniprot id: A0A1U7EVP4
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.

348780:NP RS12150
gene id: 348780:NP_RS12150
uniprot id: Q3IMV2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.

348780:NP RS07275
gene id: 348780:NP_RS07275
uniprot id: A0A1U7EWT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Nucleus

348780:NP RS07010
gene id: 348780:NP_RS07010
uniprot id: A0A1U7EWN6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

348780:NP RS11125
gene id: 348780:NP_RS11125
uniprot id: A0A1U7EYL2
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

348780:NP RS01405
gene id: 348780:NP_RS01405
uniprot id: A0A1U7ETV6
names: Similarity
messages: Belongs to the aspartokinase family.

348780:NP RS08265
gene id: 348780:NP_RS08265
uniprot id: A0A1U7EX67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.
messages: Tetramer of two components I and two components II.

348780:NP RS13045
gene id: 348780:NP_RS13045
uniprot id: A0A1U7EZJ4
names: Function
messages: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.

348780:NP RS05165
gene id: 348780:NP_RS05165
uniprot id: A0A1U7EVR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

348780:NP RS09550
gene id: 348780:NP_RS09550
uniprot id: A0A1U7EXV8
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

348780:NP RS11985
gene id: 348780:NP_RS11985
uniprot id: Q3IMY4
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

348780:NP RS05340
gene id: 348780:NP_RS05340
uniprot id: A0A1U7EVU2
names: Function
names: Subunit
messages: Interacts with chemotaxis (Che) proteins as well as flagella accessory (Fla) proteins.
messages: Involved in taxis signal transduction.

348780:NP RS10450
gene id: 348780:NP_RS10450
uniprot id: A0A1U7EYB4
names: Similarity
messages: Belongs to the Nth/MutY family.

348780:NP RS05295
gene id: 348780:NP_RS05295
uniprot id: Q3IRS9
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

348780:NP RS13060
gene id: 348780:NP_RS13060
uniprot id: A0A1U7EZL4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

348780:NP RS09120
gene id: 348780:NP_RS09120
uniprot id: Q3IPL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

348780:NP RS05555
gene id: 348780:NP_RS05555
uniprot id: A0A1U7EVX8
names: Similarity
messages: Belongs to the AAA ATPase family.

348780:NP RS05635
gene id: 348780:NP_RS05635
uniprot id: A0A1U7EVY7
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS02645
gene id: 348780:NP_RS02645
uniprot id: Q3IUT9
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS10240
gene id: 348780:NP_RS10240
uniprot id: Q3INZ0
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

348780:NP RS05660
gene id: 348780:NP_RS05660
uniprot id: A0A1U7EVZ4
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

348780:NP RS00810
gene id: 348780:NP_RS00810
uniprot id: A0A1U7ETL0
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

348780:NP RS00280
gene id: 348780:NP_RS00280
uniprot id: A0A1U7ETC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

348780:NP RS09125
gene id: 348780:NP_RS09125
uniprot id: Q3IPL1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FPP/GGPP synthase family.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Probably involved in biosynthesis of the precursor for C25 (sesterterpanyl chain) moiety of C20-C25 diether (2-O-sesterterpanyl-3-O-phytanyl-sn-glycer) membrane lipid. Catalyzes the condensation of isopentenyl pyrophosphate with the allylic pyrophosphates to yield geranylfarnesyl diphosphate (GFPP). Geranylgeranyl diphosphate (GGPP) is the preferred substrate, but dimethylallyl diphosphate (DMAPP) and farnesyl diphosphate (FPP) can also be used as allylic substrate.

348780:NP RS00885
gene id: 348780:NP_RS00885
uniprot id: Q3IUB7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

348780:NP RS02540
gene id: 348780:NP_RS02540
uniprot id: Q3ITD6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

348780:NP RS10230
gene id: 348780:NP_RS10230
uniprot id: A0A1U7EY64
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

348780:NP RS04405
gene id: 348780:NP_RS04405
uniprot id: A0A1U7EVC1
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS07680
gene id: 348780:NP_RS07680
uniprot id: Q3IQF1
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS06155
gene id: 348780:NP_RS06155
uniprot id: A0A1U7EW84
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

348780:NP RS03295
gene id: 348780:NP_RS03295
uniprot id: A0A1U7EUT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

348780:NP RS07905
gene id: 348780:NP_RS07905
uniprot id: A0A1U7EX61
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

348780:NP RS00065
gene id: 348780:NP_RS00065
uniprot id: Q3IUS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.

348780:NP RS01935
gene id: 348780:NP_RS01935
uniprot id: A0A1U7EU46
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

348780:NP RS01840
gene id: 348780:NP_RS01840
uniprot id: Q3ITS8
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

348780:NP RS09240
gene id: 348780:NP_RS09240
uniprot id: Q3IPJ1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

348780:NP RS09685
gene id: 348780:NP_RS09685
uniprot id: A0A1U7EXX1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

348780:NP RS00195
gene id: 348780:NP_RS00195
uniprot id: A0A1U7ETB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

348780:NP RS05700
gene id: 348780:NP_RS05700
uniprot id: A0A1U7EVZ0
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS06990
gene id: 348780:NP_RS06990
uniprot id: Q3IQT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

348780:NP RS02315
gene id: 348780:NP_RS02315
uniprot id: A0A1U7EUB9
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

348780:NP RS02745
gene id: 348780:NP_RS02745
uniprot id: A0A1U7EUJ7
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

348780:NP RS10215
gene id: 348780:NP_RS10215
uniprot id: A0A1U7EY76
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS10770
gene id: 348780:NP_RS10770
uniprot id: A0A1U7EYE7
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

348780:NP RS06100
gene id: 348780:NP_RS06100
uniprot id: A0A1U7EW96
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

348780:NP RS02640
gene id: 348780:NP_RS02640
uniprot id: A0A1U7EUG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the oxidation of methyl-H(4)MPT to methylene-H(4)MPT.
messages: Cytoplasm

348780:NP RS07980
gene id: 348780:NP_RS07980
uniprot id: Q3IQ95
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

348780:NP RS00250
gene id: 348780:NP_RS00250
uniprot id: A0A1U7ETB8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

348780:NP RS06905
gene id: 348780:NP_RS06905
uniprot id: A0A1U7EWM3
names: Subcellular Location Annotation
messages: Membrane

348780:NP RS01550
gene id: 348780:NP_RS01550
uniprot id: A0A1U7ETX5
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

348780:NP RS09105
gene id: 348780:NP_RS09105
uniprot id: Q3IPL6
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

348780:NP RS02040
gene id: 348780:NP_RS02040
uniprot id: Q3ITN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

348780:NP RS12490
gene id: 348780:NP_RS12490
uniprot id: Q3IMN0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

348780:NP RS11235
gene id: 348780:NP_RS11235
uniprot id: A0A1U7EYR0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

348780:NP RS05640
gene id: 348780:NP_RS05640
uniprot id: A0A1U7EVZ3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.