333146:FACI RS08595
gene id: 333146:FACI_RS08595
uniprot id: S0ARU5
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

333146:FACI RS03735
gene id: 333146:FACI_RS03735
uniprot id: S0APB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

333146:FACI RS01020
gene id: 333146:FACI_RS01020
uniprot id: S0AN58
names: Similarity
messages: Belongs to the PrpD family.

333146:FACI RS03210
gene id: 333146:FACI_RS03210
uniprot id: S0ANZ6
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

333146:FACI RS07245
gene id: 333146:FACI_RS07245
uniprot id: S0ATK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

333146:FACI RS02675
gene id: 333146:FACI_RS02675
uniprot id: S0AQS5
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

333146:FACI RS00835
gene id: 333146:FACI_RS00835
uniprot id: S0AN24
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS09455
gene id: 333146:FACI_RS09455
uniprot id: S0AU38
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

333146:FACI RS03495
gene id: 333146:FACI_RS03495
uniprot id: S0AN43
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

333146:FACI RS02095
gene id: 333146:FACI_RS02095
uniprot id: S0AQF7
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

333146:FACI RS00675
gene id: 333146:FACI_RS00675
uniprot id: S0APX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

333146:FACI RS03290
gene id: 333146:FACI_RS03290
uniprot id: S0AN02
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

333146:FACI RS05470
gene id: 333146:FACI_RS05470
uniprot id: S0AQ62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.

333146:FACI RS02075
gene id: 333146:FACI_RS02075
uniprot id: S0AQQ9
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS09450
gene id: 333146:FACI_RS09450
uniprot id: S0AU47
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

333146:FACI RS07365
gene id: 333146:FACI_RS07365
uniprot id: S0AQE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

333146:FACI RS04525
gene id: 333146:FACI_RS04525
uniprot id: S0APS3
names: Similarity
messages: Belongs to the UMP kinase family.

333146:FACI RS06460
gene id: 333146:FACI_RS06460
uniprot id: S0AQS9
names: Similarity
messages: Belongs to the archease family.

333146:FACI RS06830
gene id: 333146:FACI_RS06830
uniprot id: S0ATG0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

333146:FACI RS05660
gene id: 333146:FACI_RS05660
uniprot id: S0ASQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

333146:FACI RS05810
gene id: 333146:FACI_RS05810
uniprot id: S0ASU5
names: Similarity
messages: Belongs to the HMBS family.

333146:FACI RS04620
gene id: 333146:FACI_RS04620
uniprot id: S0APT9
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

333146:FACI RS02090
gene id: 333146:FACI_RS02090
uniprot id: S0AM91
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

333146:FACI RS00760
gene id: 333146:FACI_RS00760
uniprot id: S0AN10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

333146:FACI RS07270
gene id: 333146:FACI_RS07270
uniprot id: S0AQB9
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

333146:FACI RS06125
gene id: 333146:FACI_RS06125
uniprot id: S0APL2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

333146:FACI RS04660
gene id: 333146:FACI_RS04660
uniprot id: S0ASC3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

333146:FACI RS05065
gene id: 333146:FACI_RS05065
uniprot id: S0AQE7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

333146:FACI RS05005
gene id: 333146:FACI_RS05005
uniprot id: S0ASA4
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

333146:FACI RS02640
gene id: 333146:FACI_RS02640
uniprot id: S0AP19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

333146:FACI RS07790
gene id: 333146:FACI_RS07790
uniprot id: S0AQM6
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

333146:FACI RS09260
gene id: 333146:FACI_RS09260
uniprot id: S0AU30
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

333146:FACI RS05715
gene id: 333146:FACI_RS05715
uniprot id: S0AQA8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

333146:FACI RS09025
gene id: 333146:FACI_RS09025
uniprot id: S0ASP8
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

333146:FACI RS04060
gene id: 333146:FACI_RS04060
uniprot id: S0ANH7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

333146:FACI RS02555
gene id: 333146:FACI_RS02555
uniprot id: S0AQQ6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

333146:FACI RS03655
gene id: 333146:FACI_RS03655
uniprot id: S0ARF7
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

333146:FACI RS04055
gene id: 333146:FACI_RS04055
uniprot id: S0APJ9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

333146:FACI RS06495
gene id: 333146:FACI_RS06495
uniprot id: S0APV5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

333146:FACI RS07395
gene id: 333146:FACI_RS07395
uniprot id: S0ATM8
names: Similarity
messages: Belongs to the ferrochelatase family.

333146:FACI RS06080
gene id: 333146:FACI_RS06080
uniprot id: S0ASZ7
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

333146:FACI RS07775
gene id: 333146:FACI_RS07775
uniprot id: S0ATQ1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

333146:FACI RS03535
gene id: 333146:FACI_RS03535
uniprot id: S0ARI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

333146:FACI RS01385
gene id: 333146:FACI_RS01385
uniprot id: S0AQE9
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

333146:FACI RS04800
gene id: 333146:FACI_RS04800
uniprot id: S0APW0
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

333146:FACI RS04735
gene id: 333146:FACI_RS04735
uniprot id: S0ANU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

333146:FACI RS05615
gene id: 333146:FACI_RS05615
uniprot id: S0AQ89
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Membrane

333146:FACI RS02405
gene id: 333146:FACI_RS02405
uniprot id: S0AMF2
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS00285
gene id: 333146:FACI_RS00285
uniprot id: S0APB9
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS00815
gene id: 333146:FACI_RS00815
uniprot id: S0APM0
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

333146:FACI RS03610
gene id: 333146:FACI_RS03610
uniprot id: S0ARJ7
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 2 family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

333146:FACI RS01115
gene id: 333146:FACI_RS01115
uniprot id: S0AMH6
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS08035
gene id: 333146:FACI_RS08035
uniprot id: S0ATT8
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

333146:FACI RS05170
gene id: 333146:FACI_RS05170
uniprot id: S0AQG4
names: Similarity
messages: Belongs to the carbamate kinase family.

333146:FACI RS08090
gene id: 333146:FACI_RS08090
uniprot id: S0ATS6
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

333146:FACI RS04940
gene id: 333146:FACI_RS04940
uniprot id: S0AQC9
names: Similarity
messages: Belongs to the thymidylate kinase family.

333146:FACI RS03770
gene id: 333146:FACI_RS03770
uniprot id: S0AN93
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

333146:FACI RS05860
gene id: 333146:FACI_RS05860
uniprot id: S0ASV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

333146:FACI RS01810
gene id: 333146:FACI_RS01810
uniprot id: S0AQM9
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

333146:FACI RS01670
gene id: 333146:FACI_RS01670
uniprot id: S0ANJ9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

333146:FACI RS05230
gene id: 333146:FACI_RS05230
uniprot id: S0ASL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

333146:FACI RS04730
gene id: 333146:FACI_RS04730
uniprot id: S0AQA0
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

333146:FACI RS05040
gene id: 333146:FACI_RS05040
uniprot id: S0AQE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

333146:FACI RS07670
gene id: 333146:FACI_RS07670
uniprot id: S0ART7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpA family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

333146:FACI RS06675
gene id: 333146:FACI_RS06675
uniprot id: S0APY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Membrane

333146:FACI RS07740
gene id: 333146:FACI_RS07740
uniprot id: S0AQL6
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

333146:FACI RS09440
gene id: 333146:FACI_RS09440
uniprot id: S0ASW0
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS02915
gene id: 333146:FACI_RS02915
uniprot id: S0ANT8
names: Similarity
messages: Belongs to the TPP enzyme family.

333146:FACI RS07655
gene id: 333146:FACI_RS07655
uniprot id: S0ATQ3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

333146:FACI RS09645
gene id: 333146:FACI_RS09645
uniprot id: S0ASG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

333146:FACI RS09835
gene id: 333146:FACI_RS09835
uniprot id: S0AQ51
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

333146:FACI RS08660
gene id: 333146:FACI_RS08660
uniprot id: S0ATY5
names: Similarity
messages: Belongs to the LDH/MDH superfamily.

333146:FACI RS01150
gene id: 333146:FACI_RS01150
uniprot id: S0ALK7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

333146:FACI RS05750
gene id: 333146:FACI_RS05750
uniprot id: S0APE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

333146:FACI RS05630
gene id: 333146:FACI_RS05630
uniprot id: S0ASU8
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

333146:FACI RS04835
gene id: 333146:FACI_RS04835
uniprot id: S0APW2
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

333146:FACI RS08025
gene id: 333146:FACI_RS08025
uniprot id: S0ARJ0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

333146:FACI RS06035
gene id: 333146:FACI_RS06035
uniprot id: S0AQG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

333146:FACI RS04380
gene id: 333146:FACI_RS04380
uniprot id: S0AQ44
names: Function
messages: Catalyzes the synthesis of GMP from XMP.

333146:FACI RS05640
gene id: 333146:FACI_RS05640
uniprot id: S0AQ96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

333146:FACI RS08155
gene id: 333146:FACI_RS08155
uniprot id: S0AQX4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

333146:FACI RS01225
gene id: 333146:FACI_RS01225
uniprot id: S0APV4
names: Similarity
messages: Belongs to the citrate synthase family.

333146:FACI RS05260
gene id: 333146:FACI_RS05260
uniprot id: S0AQ27
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

333146:FACI RS03325
gene id: 333146:FACI_RS03325
uniprot id: S0ARC7
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

333146:FACI RS09510
gene id: 333146:FACI_RS09510
uniprot id: S0ASX1
names: Similarity
messages: In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

333146:FACI RS05225
gene id: 333146:FACI_RS05225
uniprot id: S0AP30
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

333146:FACI RS02215
gene id: 333146:FACI_RS02215
uniprot id: S0ANU2
names: Similarity
messages: Belongs to the UDPGP type 2 family.

333146:FACI RS05910
gene id: 333146:FACI_RS05910
uniprot id: S0AQX2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Membrane

333146:FACI RS08620
gene id: 333146:FACI_RS08620
uniprot id: S0ARU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

333146:FACI RS05665
gene id: 333146:FACI_RS05665
uniprot id: S0AQ99
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

333146:FACI RS01395
gene id: 333146:FACI_RS01395
uniprot id: S0AND3
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

333146:FACI RS02000
gene id: 333146:FACI_RS02000
uniprot id: S0AQD7
names: Similarity
messages: Belongs to the PurH family.

333146:FACI RS09235
gene id: 333146:FACI_RS09235
uniprot id: S0AU28
names: Similarity
messages: Belongs to the group II decarboxylase family.

333146:FACI RS05725
gene id: 333146:FACI_RS05725
uniprot id: S0APD5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

333146:FACI RS04825
gene id: 333146:FACI_RS04825
uniprot id: S0ASE7
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

333146:FACI RS01605
gene id: 333146:FACI_RS01605
uniprot id: S0AQ67
names: Similarity
messages: Belongs to the HepT RNase toxin family.

333146:FACI RS04655
gene id: 333146:FACI_RS04655
uniprot id: S0ANT2
names: Similarity
messages: Belongs to the ZPR1 family.

333146:FACI RS04600
gene id: 333146:FACI_RS04600
uniprot id: S0APT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

333146:FACI RS01575
gene id: 333146:FACI_RS01575
uniprot id: S0ALY6
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.

333146:FACI RS00020
gene id: 333146:FACI_RS00020
uniprot id: S0AP60
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

333146:FACI RS04420
gene id: 333146:FACI_RS04420
uniprot id: S0ARY9
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

333146:FACI RS07665
gene id: 333146:FACI_RS07665
uniprot id: S0ARC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

333146:FACI RS01555
gene id: 333146:FACI_RS01555
uniprot id: S0AQ47
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

333146:FACI RS01855
gene id: 333146:FACI_RS01855
uniprot id: S0AQA3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

333146:FACI RS05655
gene id: 333146:FACI_RS05655
uniprot id: S0ASV6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

333146:FACI RS03455
gene id: 333146:FACI_RS03455
uniprot id: S0ARG5
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

333146:FACI RS08475
gene id: 333146:FACI_RS08475
uniprot id: S0ASB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

333146:FACI RS01125
gene id: 333146:FACI_RS01125
uniprot id: S0ALK0
names: Similarity
messages: Belongs to the MoaD family.

333146:FACI RS02085
gene id: 333146:FACI_RS02085
uniprot id: S0ANS4
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

333146:FACI RS04640
gene id: 333146:FACI_RS04640
uniprot id: S0AS21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

333146:FACI RS00775
gene id: 333146:FACI_RS00775
uniprot id: S0AQ00
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS08490
gene id: 333146:FACI_RS08490
uniprot id: S0ATW0
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

333146:FACI RS09425
gene id: 333146:FACI_RS09425
uniprot id: S0AU45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

333146:FACI RS08590
gene id: 333146:FACI_RS08590
uniprot id: S0ATX1
names: Similarity
messages: Belongs to the malic enzymes family.

333146:FACI RS05730
gene id: 333146:FACI_RS05730
uniprot id: S0ASX0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

333146:FACI RS08990
gene id: 333146:FACI_RS08990
uniprot id: S0AU04
names: Similarity
messages: Belongs to the peptidase M20A family.

333146:FACI RS06355
gene id: 333146:FACI_RS06355
uniprot id: S0AT57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

333146:FACI RS07350
gene id: 333146:FACI_RS07350
uniprot id: S0ATK3
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

333146:FACI RS05185
gene id: 333146:FACI_RS05185
uniprot id: S0ASE0
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

333146:FACI RS08940
gene id: 333146:FACI_RS08940
uniprot id: S0AS34
names: Similarity
messages: Belongs to the peptidase C56 family.

333146:FACI RS09190
gene id: 333146:FACI_RS09190
uniprot id: S0ASR8
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

333146:FACI RS05990
gene id: 333146:FACI_RS05990
uniprot id: S0AQY6
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

333146:FACI RS01775
gene id: 333146:FACI_RS01775
uniprot id: S0AM24
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

333146:FACI RS00805
gene id: 333146:FACI_RS00805
uniprot id: S0AN18
names: Similarity
messages: Belongs to the TPP enzyme family.

333146:FACI RS08835
gene id: 333146:FACI_RS08835
uniprot id: S0ATZ6
names: Similarity
messages: Belongs to the TPP enzyme family.

333146:FACI RS07635
gene id: 333146:FACI_RS07635
uniprot id: S0ATN6
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

333146:FACI RS03185
gene id: 333146:FACI_RS03185
uniprot id: S0ANZ2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

333146:FACI RS02685
gene id: 333146:FACI_RS02685
uniprot id: S0ANN2
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

333146:FACI RS05690
gene id: 333146:FACI_RS05690
uniprot id: S0AQA5
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

333146:FACI RS04405
gene id: 333146:FACI_RS04405
uniprot id: S0AQ50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

333146:FACI RS05255
gene id: 333146:FACI_RS05255
uniprot id: S0ASM0
names: Caution
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

333146:FACI RS05205
gene id: 333146:FACI_RS05205
uniprot id: S0ASL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

333146:FACI RS04885
gene id: 333146:FACI_RS04885
uniprot id: S0APX2
names: Similarity
messages: Belongs to the UPF0215 family.

333146:FACI RS08030
gene id: 333146:FACI_RS08030
uniprot id: S0AQU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

333146:FACI RS05670
gene id: 333146:FACI_RS05670
uniprot id: S0AQS3
names: Similarity
messages: Belongs to the SUI1 family.

333146:FACI RS03055
gene id: 333146:FACI_RS03055
uniprot id: S0APA5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

333146:FACI RS07030
gene id: 333146:FACI_RS07030
uniprot id: S0AR20
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS03650
gene id: 333146:FACI_RS03650
uniprot id: S0AN68
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

333146:FACI RS07025
gene id: 333146:FACI_RS07025
uniprot id: S0ATG4
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

333146:FACI RS08425
gene id: 333146:FACI_RS08425
uniprot id: S0ATV4
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

333146:FACI RS08200
gene id: 333146:FACI_RS08200
uniprot id: S0AS43
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS01310
gene id: 333146:FACI_RS01310
uniprot id: S0AQD4
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).

333146:FACI RS01930
gene id: 333146:FACI_RS01930
uniprot id: S0ANQ0
names: Similarity
messages: Belongs to the UbiD family.

333146:FACI RS03560
gene id: 333146:FACI_RS03560
uniprot id: S0ARI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

333146:FACI RS07830
gene id: 333146:FACI_RS07830
uniprot id: S0ARF1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

333146:FACI RS05345
gene id: 333146:FACI_RS05345
uniprot id: S0AP53
names: Similarity
messages: Belongs to the TrpF family.

333146:FACI RS02520
gene id: 333146:FACI_RS02520
uniprot id: S0ANJ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

333146:FACI RS02595
gene id: 333146:FACI_RS02595
uniprot id: S0AP10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

333146:FACI RS03730
gene id: 333146:FACI_RS03730
uniprot id: S0ARM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

333146:FACI RS04290
gene id: 333146:FACI_RS04290
uniprot id: S0AS62
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

333146:FACI RS06580
gene id: 333146:FACI_RS06580
uniprot id: S0ATB0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

333146:FACI RS07995
gene id: 333146:FACI_RS07995
uniprot id: S0ATR9
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS01600
gene id: 333146:FACI_RS01600
uniprot id: S0ALZ3
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

333146:FACI RS06395
gene id: 333146:FACI_RS06395
uniprot id: S0APS4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

333146:FACI RS01830
gene id: 333146:FACI_RS01830
uniprot id: S0AQ98
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS05510
gene id: 333146:FACI_RS05510
uniprot id: S0ASR7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

333146:FACI RS03555
gene id: 333146:FACI_RS03555
uniprot id: S0ARE0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

333146:FACI RS02720
gene id: 333146:FACI_RS02720
uniprot id: S0AQT4
names: Subcellular Location Annotation
messages: Cytoplasm

333146:FACI RS06310
gene id: 333146:FACI_RS06310
uniprot id: S0AT43
names: Similarity
messages: Belongs to the peptidase M20A family.

333146:FACI RS07785
gene id: 333146:FACI_RS07785
uniprot id: S0ARW4
names: Similarity
messages: Belongs to the TPP enzyme family.

333146:FACI RS01535
gene id: 333146:FACI_RS01535
uniprot id: S0AQI9
names: Similarity
messages: Belongs to the DtxR/MntR family.

333146:FACI RS05355
gene id: 333146:FACI_RS05355
uniprot id: S0ASI5
names: Function
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

333146:FACI RS00895
gene id: 333146:FACI_RS00895
uniprot id: S0ALD9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

333146:FACI RS02205
gene id: 333146:FACI_RS02205
uniprot id: S0AQS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

333146:FACI RS02590
gene id: 333146:FACI_RS02590
uniprot id: S0ANL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

333146:FACI RS07160
gene id: 333146:FACI_RS07160
uniprot id: S0ATK0
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

333146:FACI RS03670
gene id: 333146:FACI_RS03670
uniprot id: S0APP7
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

333146:FACI RS02705
gene id: 333146:FACI_RS02705
uniprot id: S0ANN6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

333146:FACI RS05700
gene id: 333146:FACI_RS05700
uniprot id: S0APC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

333146:FACI RS03580
gene id: 333146:FACI_RS03580
uniprot id: S0ARE5
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

333146:FACI RS07170
gene id: 333146:FACI_RS07170
uniprot id: S0AR44
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

333146:FACI RS05915
gene id: 333146:FACI_RS05915
uniprot id: S0APH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

333146:FACI RS06995
gene id: 333146:FACI_RS06995
uniprot id: S0ATI1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

333146:FACI RS05085
gene id: 333146:FACI_RS05085
uniprot id: S0APZ8
names: Similarity
messages: Belongs to the band 7/mec-2 family.

333146:FACI RS00905
gene id: 333146:FACI_RS00905
uniprot id: S0AQ31
names: Similarity
messages: Belongs to the citrate synthase family.

333146:FACI RS03465
gene id: 333146:FACI_RS03465
uniprot id: S0APJ6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

333146:FACI RS05875
gene id: 333146:FACI_RS05875
uniprot id: S0AQW5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

333146:FACI RS01320
gene id: 333146:FACI_RS01320
uniprot id: S0ANB9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

333146:FACI RS07990
gene id: 333146:FACI_RS07990
uniprot id: S0ATT3
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS08310
gene id: 333146:FACI_RS08310
uniprot id: S0ATU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

333146:FACI RS09105
gene id: 333146:FACI_RS09105
uniprot id: S0AU19
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS02290
gene id: 333146:FACI_RS02290
uniprot id: S0AQJ0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

333146:FACI RS03570
gene id: 333146:FACI_RS03570
uniprot id: S0APM3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

333146:FACI RS00035
gene id: 333146:FACI_RS00035
uniprot id: S0AMK9
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

333146:FACI RS06465
gene id: 333146:FACI_RS06465
uniprot id: S0AR88
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

333146:FACI RS07430
gene id: 333146:FACI_RS07430
uniprot id: S0AR83
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

333146:FACI RS05385
gene id: 333146:FACI_RS05385
uniprot id: S0ASJ2
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

333146:FACI RS06680
gene id: 333146:FACI_RS06680
uniprot id: S0ATE6
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

333146:FACI RS02740
gene id: 333146:FACI_RS02740
uniprot id: S0AMN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

333146:FACI RS07425
gene id: 333146:FACI_RS07425
uniprot id: S0ATL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

333146:FACI RS02395
gene id: 333146:FACI_RS02395
uniprot id: S0ANG5
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

333146:FACI RS04570
gene id: 333146:FACI_RS04570
uniprot id: S0AS08
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

333146:FACI RS08665
gene id: 333146:FACI_RS08665
uniprot id: S0ATX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

333146:FACI RS07020
gene id: 333146:FACI_RS07020
uniprot id: S0ATI4
names: Subcellular Location Annotation
messages: Cytoplasm

333146:FACI RS02010
gene id: 333146:FACI_RS02010
uniprot id: S0AN88
names: Similarity
messages: Belongs to the peptidase S45 family.

333146:FACI RS04950
gene id: 333146:FACI_RS04950
uniprot id: S0ASH0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

333146:FACI RS05720
gene id: 333146:FACI_RS05720
uniprot id: S0AQT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

333146:FACI RS04875
gene id: 333146:FACI_RS04875
uniprot id: S0ASF6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

333146:FACI RS07945
gene id: 333146:FACI_RS07945
uniprot id: S0ATR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Homodimer.
messages: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0).

333146:FACI RS01740
gene id: 333146:FACI_RS01740
uniprot id: S0AMZ7
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

333146:FACI RS02715
gene id: 333146:FACI_RS02715
uniprot id: S0AMN0
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS07480
gene id: 333146:FACI_RS07480
uniprot id: S0ATN3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

333146:FACI RS02160
gene id: 333146:FACI_RS02160
uniprot id: S0ANC0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

333146:FACI RS05045
gene id: 333146:FACI_RS05045
uniprot id: S0AP02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

333146:FACI RS07965
gene id: 333146:FACI_RS07965
uniprot id: S0ATT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

333146:FACI RS03040
gene id: 333146:FACI_RS03040
uniprot id: S0AR13
names: Similarity
messages: Belongs to the UPF0111 family.

333146:FACI RS01340
gene id: 333146:FACI_RS01340
uniprot id: S0AMM9
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

333146:FACI RS02830
gene id: 333146:FACI_RS02830
uniprot id: S0AMQ0
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

333146:FACI RS02115
gene id: 333146:FACI_RS02115
uniprot id: S0AM98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Membrane

333146:FACI RS05920
gene id: 333146:FACI_RS05920
uniprot id: S0ASW8
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

333146:FACI RS04295
gene id: 333146:FACI_RS04295
uniprot id: S0ARX0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Cytoplasm
messages: In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

333146:FACI RS07340
gene id: 333146:FACI_RS07340
uniprot id: S0ARN4
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS06130
gene id: 333146:FACI_RS06130
uniprot id: S0AT45
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

333146:FACI RS07890
gene id: 333146:FACI_RS07890
uniprot id: S0AQQ2
names: Similarity
messages: Belongs to the PGI/PMI family.

333146:FACI RS04385
gene id: 333146:FACI_RS04385
uniprot id: S0ANN0
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

333146:FACI RS08995
gene id: 333146:FACI_RS08995
uniprot id: S0AS42
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

333146:FACI RS08955
gene id: 333146:FACI_RS08955
uniprot id: S0AU08
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

333146:FACI RS09275
gene id: 333146:FACI_RS09275
uniprot id: S0AST3
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS04285
gene id: 333146:FACI_RS04285
uniprot id: S0ANL5
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

333146:FACI RS07860
gene id: 333146:FACI_RS07860
uniprot id: S0ARX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

333146:FACI RS05035
gene id: 333146:FACI_RS05035
uniprot id: S0APY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

333146:FACI RS08150
gene id: 333146:FACI_RS08150
uniprot id: S0AS32
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

333146:FACI RS06000
gene id: 333146:FACI_RS06000
uniprot id: S0AT23
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS02610
gene id: 333146:FACI_RS02610
uniprot id: S0AQZ4
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.

333146:FACI RS06905
gene id: 333146:FACI_RS06905
uniprot id: S0ATE9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

333146:FACI RS06370
gene id: 333146:FACI_RS06370
uniprot id: S0APR9
names: Similarity
messages: Belongs to the UPF0179 family.

333146:FACI RS01450
gene id: 333146:FACI_RS01450
uniprot id: S0ALV6
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

333146:FACI RS05840
gene id: 333146:FACI_RS05840
uniprot id: S0AQD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

333146:FACI RS07240
gene id: 333146:FACI_RS07240
uniprot id: S0AQB4
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

333146:FACI RS09445
gene id: 333146:FACI_RS09445
uniprot id: S0ARP4
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS02580
gene id: 333146:FACI_RS02580
uniprot id: S0AQR0
names: Similarity
messages: Belongs to the group II decarboxylase family.

333146:FACI RS04610
gene id: 333146:FACI_RS04610
uniprot id: S0ASB3
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

333146:FACI RS09385
gene id: 333146:FACI_RS09385
uniprot id: S0AU33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

333146:FACI RS08885
gene id: 333146:FACI_RS08885
uniprot id: S0AU00
names: Similarity
messages: Belongs to the heat shock protein 70 family.

333146:FACI RS06235
gene id: 333146:FACI_RS06235
uniprot id: S0AT30
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

333146:FACI RS02180
gene id: 333146:FACI_RS02180
uniprot id: S0AQS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

333146:FACI RS01105
gene id: 333146:FACI_RS01105
uniprot id: S0APT3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

333146:FACI RS05435
gene id: 333146:FACI_RS05435
uniprot id: S0ASK4
names: Similarity
messages: Belongs to the glutaredoxin family.

333146:FACI RS01300
gene id: 333146:FACI_RS01300
uniprot id: S0ALQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

333146:FACI RS00525
gene id: 333146:FACI_RS00525
uniprot id: S0APG4
names: Function
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.
messages: Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway.

333146:FACI RS05320
gene id: 333146:FACI_RS05320
uniprot id: S0AP49
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

333146:FACI RS05050
gene id: 333146:FACI_RS05050
uniprot id: S0ASI7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

333146:FACI RS06380
gene id: 333146:FACI_RS06380
uniprot id: S0AT67
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

333146:FACI RS06470
gene id: 333146:FACI_RS06470
uniprot id: S0APU9
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

333146:FACI RS07685
gene id: 333146:FACI_RS07685
uniprot id: S0ARC5
names: Similarity
messages: Belongs to the MEMO1 family.

333146:FACI RS00755
gene id: 333146:FACI_RS00755
uniprot id: S0AM99
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS01440
gene id: 333146:FACI_RS01440
uniprot id: S0AMR0
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS05155
gene id: 333146:FACI_RS05155
uniprot id: S0ASK3
names: Similarity
messages: Belongs to the UPF0147 family.

333146:FACI RS00800
gene id: 333146:FACI_RS00800
uniprot id: S0AMA9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

333146:FACI RS01500
gene id: 333146:FACI_RS01500
uniprot id: S0ALX3
names: Subcellular Location Annotation
messages: Cell membrane

333146:FACI RS01090
gene id: 333146:FACI_RS01090
uniprot id: S0AMH0
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS02065
gene id: 333146:FACI_RS02065
uniprot id: S0AM87
names: Similarity
messages: Belongs to the carbamate kinase family.

333146:FACI RS07760
gene id: 333146:FACI_RS07760
uniprot id: S0ARV8
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

333146:FACI RS08305
gene id: 333146:FACI_RS08305
uniprot id: S0ATV6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

333146:FACI RS00330
gene id: 333146:FACI_RS00330
uniprot id: S0APC7
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

333146:FACI RS06330
gene id: 333146:FACI_RS06330
uniprot id: S0AT78
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

333146:FACI RS06655
gene id: 333146:FACI_RS06655
uniprot id: S0ATE2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

333146:FACI RS03385
gene id: 333146:FACI_RS03385
uniprot id: S0APH8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

333146:FACI RS06250
gene id: 333146:FACI_RS06250
uniprot id: S0APP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

333146:FACI RS01380
gene id: 333146:FACI_RS01380
uniprot id: S0APZ1
names: Similarity
messages: Belongs to the DMRL synthase family.

333146:FACI RS02300
gene id: 333146:FACI_RS02300
uniprot id: S0ANE8
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

333146:FACI RS07055
gene id: 333146:FACI_RS07055
uniprot id: S0AR25
names: Similarity
messages: Belongs to the HsdR family.

333146:FACI RS04425
gene id: 333146:FACI_RS04425
uniprot id: S0APQ1
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

333146:FACI RS02260
gene id: 333146:FACI_RS02260
uniprot id: S0AND9
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

333146:FACI RS06245
gene id: 333146:FACI_RS06245
uniprot id: S0AR36
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the RNA polymerase complex.

333146:FACI RS04590
gene id: 333146:FACI_RS04590
uniprot id: S0ASB0
names: Similarity
messages: Belongs to the UPF0045 family.

333146:FACI RS03520
gene id: 333146:FACI_RS03520
uniprot id: S0AN48
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

333146:FACI RS05415
gene id: 333146:FACI_RS05415
uniprot id: S0AQ53
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

333146:FACI RS07935
gene id: 333146:FACI_RS07935
uniprot id: S0AQR4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

333146:FACI RS00710
gene id: 333146:FACI_RS00710
uniprot id: S0AMZ5
names: Similarity
messages: Belongs to the 4HPPD family.

333146:FACI RS00660
gene id: 333146:FACI_RS00660
uniprot id: S0AMY6
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

333146:FACI RS03565
gene id: 333146:FACI_RS03565
uniprot id: S0AP73
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

333146:FACI RS08875
gene id: 333146:FACI_RS08875
uniprot id: S0ASK8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GmhB family.
messages: Cytoplasm
messages: Monomer.

333146:FACI RS06545
gene id: 333146:FACI_RS06545
uniprot id: S0APW3
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

333146:FACI RS08980
gene id: 333146:FACI_RS08980
uniprot id: S0ARH7
names: Similarity
messages: Belongs to the cytochrome P450 family.

333146:FACI RS07940
gene id: 333146:FACI_RS07940
uniprot id: S0ATS7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

333146:FACI RS01280
gene id: 333146:FACI_RS01280
uniprot id: S0APW6
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS04435
gene id: 333146:FACI_RS04435
uniprot id: S0ANN8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

333146:FACI RS07625
gene id: 333146:FACI_RS07625
uniprot id: S0AQI5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family. LysK subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
messages: Cytoplasm

333146:FACI RS00430
gene id: 333146:FACI_RS00430
uniprot id: S0APS8
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS05645
gene id: 333146:FACI_RS05645
uniprot id: S0AQR8
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

333146:FACI RS05060
gene id: 333146:FACI_RS05060
uniprot id: S0APZ3
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.

333146:FACI RS04630
gene id: 333146:FACI_RS04630
uniprot id: S0ANS5
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.

333146:FACI RS08080
gene id: 333146:FACI_RS08080
uniprot id: S0AQV5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

333146:FACI RS03890
gene id: 333146:FACI_RS03890
uniprot id: S0APF4
names: Similarity
messages: Belongs to the proline racemase family.

333146:FACI RS02370
gene id: 333146:FACI_RS02370
uniprot id: S0ANG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Cytoplasm

333146:FACI RS04360
gene id: 333146:FACI_RS04360
uniprot id: S0ANM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

333146:FACI RS07835
gene id: 333146:FACI_RS07835
uniprot id: S0ARX2
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

333146:FACI RS03110
gene id: 333146:FACI_RS03110
uniprot id: S0ANX4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

333146:FACI RS01825
gene id: 333146:FACI_RS01825
uniprot id: S0AM33
names: Cofactor
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

333146:FACI RS03075
gene id: 333146:FACI_RS03075
uniprot id: S0ANX0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

333146:FACI RS05805
gene id: 333146:FACI_RS05805
uniprot id: S0ASY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

333146:FACI RS05855
gene id: 333146:FACI_RS05855
uniprot id: S0ASZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

333146:FACI RS03195
gene id: 333146:FACI_RS03195
uniprot id: S0AMX6
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

333146:FACI RS05350
gene id: 333146:FACI_RS05350
uniprot id: S0ASN7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

333146:FACI RS07310
gene id: 333146:FACI_RS07310
uniprot id: S0AR64
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS03745
gene id: 333146:FACI_RS03745
uniprot id: S0AN87
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

333146:FACI RS01525
gene id: 333146:FACI_RS01525
uniprot id: S0ALX9
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

333146:FACI RS09805
gene id: 333146:FACI_RS09805
uniprot id: S0AQZ2
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

333146:FACI RS07415
gene id: 333146:FACI_RS07415
uniprot id: S0AQF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

333146:FACI RS09120
gene id: 333146:FACI_RS09120
uniprot id: S0ASQ8
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS06420
gene id: 333146:FACI_RS06420
uniprot id: S0APT1
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

333146:FACI RS02070
gene id: 333146:FACI_RS02070
uniprot id: S0AQF5
names: Similarity
messages: Belongs to the cytochrome P450 family.

333146:FACI RS06810
gene id: 333146:FACI_RS06810
uniprot id: S0ATD6
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS00655
gene id: 333146:FACI_RS00655
uniprot id: S0AM79
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

333146:FACI RS04695
gene id: 333146:FACI_RS04695
uniprot id: S0AS30
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

333146:FACI RS03120
gene id: 333146:FACI_RS03120
uniprot id: S0AMV6
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

333146:FACI RS05680
gene id: 333146:FACI_RS05680
uniprot id: S0ASW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

333146:FACI RS07360
gene id: 333146:FACI_RS07360
uniprot id: S0ARN9
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

333146:FACI RS02755
gene id: 333146:FACI_RS02755
uniprot id: S0ANP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

333146:FACI RS09500
gene id: 333146:FACI_RS09500
uniprot id: S0AU42
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

333146:FACI RS08060
gene id: 333146:FACI_RS08060
uniprot id: S0ATT9
names: Similarity
messages: Belongs to the HypE family.

333146:FACI RS05090
gene id: 333146:FACI_RS05090
uniprot id: S0AQF3
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

333146:FACI RS04160
gene id: 333146:FACI_RS04160
uniprot id: S0ANJ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

333146:FACI RS06390
gene id: 333146:FACI_RS06390
uniprot id: S0AR63
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

333146:FACI RS00050
gene id: 333146:FACI_RS00050
uniprot id: S0APK4
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

333146:FACI RS05985
gene id: 333146:FACI_RS05985
uniprot id: S0AQF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

333146:FACI RS05735
gene id: 333146:FACI_RS05735
uniprot id: S0ASS3
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

333146:FACI RS07380
gene id: 333146:FACI_RS07380
uniprot id: S0AR74
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

333146:FACI RS06915
gene id: 333146:FACI_RS06915
uniprot id: S0ARG1
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

333146:FACI RS07010
gene id: 333146:FACI_RS07010
uniprot id: S0ARH6
names: Similarity
messages: Belongs to the peptidase M24B family.

333146:FACI RS01655
gene id: 333146:FACI_RS01655
uniprot id: S0AQ74
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS04110
gene id: 333146:FACI_RS04110
uniprot id: S0AS36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

333146:FACI RS08130
gene id: 333146:FACI_RS08130
uniprot id: S0AQW8
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS01665
gene id: 333146:FACI_RS01665
uniprot id: S0AMX7
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

333146:FACI RS00510
gene id: 333146:FACI_RS00510
uniprot id: S0AM46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

333146:FACI RS00085
gene id: 333146:FACI_RS00085
uniprot id: S0AP77
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

333146:FACI RS04935
gene id: 333146:FACI_RS04935
uniprot id: S0APX8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

333146:FACI RS05760
gene id: 333146:FACI_RS05760
uniprot id: S0AST1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

333146:FACI RS08075
gene id: 333146:FACI_RS08075
uniprot id: S0AS15
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

333146:FACI RS05490
gene id: 333146:FACI_RS05490
uniprot id: S0ASL8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

333146:FACI RS03615
gene id: 333146:FACI_RS03615
uniprot id: S0AP85
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

333146:FACI RS05210
gene id: 333146:FACI_RS05210
uniprot id: S0ASE8
names: Similarity
messages: Belongs to the PDCD5 family.

333146:FACI RS08465
gene id: 333146:FACI_RS08465
uniprot id: S0ATW9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

333146:FACI RS08205
gene id: 333146:FACI_RS08205
uniprot id: S0AQY8
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane

333146:FACI RS06320
gene id: 333146:FACI_RS06320
uniprot id: S0AR47
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS04495
gene id: 333146:FACI_RS04495
uniprot id: S0ARZ9
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS02585
gene id: 333146:FACI_RS02585
uniprot id: S0AQY9
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

333146:FACI RS02515
gene id: 333146:FACI_RS02515
uniprot id: S0AQX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

333146:FACI RS05850
gene id: 333146:FACI_RS05850
uniprot id: S0APG2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

333146:FACI RS00570
gene id: 333146:FACI_RS00570
uniprot id: S0AL56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 2 family.
messages: Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

333146:FACI RS02615
gene id: 333146:FACI_RS02615
uniprot id: S0ANL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm

333146:FACI RS04690
gene id: 333146:FACI_RS04690
uniprot id: S0ASC7
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

333146:FACI RS01585
gene id: 333146:FACI_RS01585
uniprot id: S0AQJ8
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS04235
gene id: 333146:FACI_RS04235
uniprot id: S0ANK6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

333146:FACI RS05330
gene id: 333146:FACI_RS05330
uniprot id: S0ASI1
names: Similarity
messages: Belongs to the TrpC family.

333146:FACI RS08655
gene id: 333146:FACI_RS08655
uniprot id: S0ARA0
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

333146:FACI RS04440
gene id: 333146:FACI_RS04440
uniprot id: S0AS85
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

333146:FACI RS01710
gene id: 333146:FACI_RS01710
uniprot id: S0AQL8
names: Similarity
messages: Belongs to the UPF0173 family.

333146:FACI RS00810
gene id: 333146:FACI_RS00810
uniprot id: S0ALC0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

333146:FACI RS02035
gene id: 333146:FACI_RS02035
uniprot id: S0AN92
names: Similarity
messages: Belongs to the acetyltransferase family. MAK3 subfamily.

333146:FACI RS05515
gene id: 333146:FACI_RS05515
uniprot id: S0ASM6
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.

333146:FACI RS04645
gene id: 333146:FACI_RS04645
uniprot id: S0APU2
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS05610
gene id: 333146:FACI_RS05610
uniprot id: S0ASP6
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 2 family.

333146:FACI RS06605
gene id: 333146:FACI_RS06605
uniprot id: S0ATD5
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

333146:FACI RS01490
gene id: 333146:FACI_RS01490
uniprot id: S0AMT8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.

333146:FACI RS02045
gene id: 333146:FACI_RS02045
uniprot id: S0AM81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

333146:FACI RS05495
gene id: 333146:FACI_RS05495
uniprot id: S0AQ66
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

333146:FACI RS05745
gene id: 333146:FACI_RS05745
uniprot id: S0AQT7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

333146:FACI RS06060
gene id: 333146:FACI_RS06060
uniprot id: S0AQH2
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

333146:FACI RS04575
gene id: 333146:FACI_RS04575
uniprot id: S0APT2
names: Function
names: Similarity
messages: Belongs to the type-2 OGG1 family.
messages: Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites).

333146:FACI RS05395
gene id: 333146:FACI_RS05395
uniprot id: S0AQL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

333146:FACI RS05390
gene id: 333146:FACI_RS05390
uniprot id: S0AQ48
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

333146:FACI RS08180
gene id: 333146:FACI_RS08180
uniprot id: S0AQY0
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS07765
gene id: 333146:FACI_RS07765
uniprot id: S0AQM1
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS03485
gene id: 333146:FACI_RS03485
uniprot id: S0AP55
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

333146:FACI RS01255
gene id: 333146:FACI_RS01255
uniprot id: S0AQC2
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

333146:FACI RS05870
gene id: 333146:FACI_RS05870
uniprot id: S0AQD8
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

333146:FACI RS08005
gene id: 333146:FACI_RS08005
uniprot id: S0AS03
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

333146:FACI RS03760
gene id: 333146:FACI_RS03760
uniprot id: S0APC0
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

333146:FACI RS03335
gene id: 333146:FACI_RS03335
uniprot id: S0APG7
names: Similarity
messages: Belongs to the HerA family.

333146:FACI RS06025
gene id: 333146:FACI_RS06025
uniprot id: S0AT27
names: Similarity
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.

333146:FACI RS07370
gene id: 333146:FACI_RS07370
uniprot id: S0ATM3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

333146:FACI RS08395
gene id: 333146:FACI_RS08395
uniprot id: S0AS93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S41B family.
messages: Cytoplasm
messages: Degrades oligopeptides.

333146:FACI RS05500
gene id: 333146:FACI_RS05500
uniprot id: S0AQP4
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

333146:FACI RS04820
gene id: 333146:FACI_RS04820
uniprot id: S0ANW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

333146:FACI RS05030
gene id: 333146:FACI_RS05030
uniprot id: S0ASA8
names: Similarity
messages: Belongs to the SDO1/SBDS family.

333146:FACI RS05755
gene id: 333146:FACI_RS05755
uniprot id: S0ASY2
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS06795
gene id: 333146:FACI_RS06795
uniprot id: S0ARE2
names: Similarity
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.

333146:FACI RS01175
gene id: 333146:FACI_RS01175
uniprot id: S0APU5
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

333146:FACI RS04100
gene id: 333146:FACI_RS04100
uniprot id: S0AQ08
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

333146:FACI RS05080
gene id: 333146:FACI_RS05080
uniprot id: S0ASB9
names: Caution
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

333146:FACI RS00915
gene id: 333146:FACI_RS00915
uniprot id: S0AN41
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS06100
gene id: 333146:FACI_RS06100
uniprot id: S0APK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

333146:FACI RS06105
gene id: 333146:FACI_RS06105
uniprot id: S0AT40
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

333146:FACI RS03490
gene id: 333146:FACI_RS03490
uniprot id: S0APK2
names: Similarity
messages: Belongs to the pyruvate kinase family.

333146:FACI RS05240
gene id: 333146:FACI_RS05240
uniprot id: S0AQ21
names: Similarity
messages: Belongs to the peptidase S49 family.

333146:FACI RS00150
gene id: 333146:FACI_RS00150
uniprot id: S0AMN2
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS03820
gene id: 333146:FACI_RS03820
uniprot id: S0ANA2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

333146:FACI RS01180
gene id: 333146:FACI_RS01180
uniprot id: S0AQA1
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

333146:FACI RS03515
gene id: 333146:FACI_RS03515
uniprot id: S0APK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

333146:FACI RS04120
gene id: 333146:FACI_RS04120
uniprot id: S0APL0
names: Subcellular Location Annotation
messages: Cell membrane

333146:FACI RS04780
gene id: 333146:FACI_RS04780
uniprot id: S0AQA6
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 zinc ion.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

333146:FACI RS04005
gene id: 333146:FACI_RS04005
uniprot id: S0ARS9
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

333146:FACI RS02050
gene id: 333146:FACI_RS02050
uniprot id: S0AQQ7
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS04115
gene id: 333146:FACI_RS04115
uniprot id: S0ARU6
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

333146:FACI RS05215
gene id: 333146:FACI_RS05215
uniprot id: S0AQ19
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

333146:FACI RS04520
gene id: 333146:FACI_RS04520
uniprot id: S0AS01
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS01015
gene id: 333146:FACI_RS01015
uniprot id: S0AMF1
names: Function
names: Similarity
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
messages: Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.

333146:FACI RS00015
gene id: 333146:FACI_RS00015
uniprot id: S0AKU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

333146:FACI RS07730
gene id: 333146:FACI_RS07730
uniprot id: S0ARD4
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

333146:FACI RS09480
gene id: 333146:FACI_RS09480
uniprot id: S0AU40
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Homodimer.
messages: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0).

333146:FACI RS06865
gene id: 333146:FACI_RS06865
uniprot id: S0AQZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

333146:FACI RS04530
gene id: 333146:FACI_RS04530
uniprot id: S0AQ68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

333146:FACI RS04750
gene id: 333146:FACI_RS04750
uniprot id: S0APV2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

333146:FACI RS05250
gene id: 333146:FACI_RS05250
uniprot id: S0AP34
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

333146:FACI RS08265
gene id: 333146:FACI_RS08265
uniprot id: S0ATT7
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS03420
gene id: 333146:FACI_RS03420
uniprot id: S0ARA9
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

333146:FACI RS09140
gene id: 333146:FACI_RS09140
uniprot id: S0AS64
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

333146:FACI RS09145
gene id: 333146:FACI_RS09145
uniprot id: S0ASR0
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

333146:FACI RS00700
gene id: 333146:FACI_RS00700
uniprot id: S0APY2
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

333146:FACI RS08165
gene id: 333146:FACI_RS08165
uniprot id: S0ATT1
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

333146:FACI RS06140
gene id: 333146:FACI_RS06140
uniprot id: S0AQI8
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

333146:FACI RS00575
gene id: 333146:FACI_RS00575
uniprot id: S0APH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

333146:FACI RS05595
gene id: 333146:FACI_RS05595
uniprot id: S0AQR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

333146:FACI RS04700
gene id: 333146:FACI_RS04700
uniprot id: S0APU7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

333146:FACI RS04540
gene id: 333146:FACI_RS04540
uniprot id: S0ASA2
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

333146:FACI RS08160
gene id: 333146:FACI_RS08160
uniprot id: S0ATU6
names: Similarity
messages: Belongs to the complex I subunit 3 family.

333146:FACI RS03025
gene id: 333146:FACI_RS03025
uniprot id: S0ANV8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

333146:FACI RS00480
gene id: 333146:FACI_RS00480
uniprot id: S0APT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

333146:FACI RS03390
gene id: 333146:FACI_RS03390
uniprot id: S0AN25
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

333146:FACI RS00555
gene id: 333146:FACI_RS00555
uniprot id: S0APV3
names: Similarity
messages: Belongs to the glutamate synthase family.

333146:FACI RS03165
gene id: 333146:FACI_RS03165
uniprot id: S0ANY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

333146:FACI RS00025
gene id: 333146:FACI_RS00025
uniprot id: S0APJ8
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

333146:FACI RS00610
gene id: 333146:FACI_RS00610
uniprot id: S0AM68
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm

333146:FACI RS05110
gene id: 333146:FACI_RS05110
uniprot id: S0AQ02
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS08670
gene id: 333146:FACI_RS08670
uniprot id: S0ARV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

333146:FACI RS06260
gene id: 333146:FACI_RS06260
uniprot id: S0AT37
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

333146:FACI RS08210
gene id: 333146:FACI_RS08210
uniprot id: S0ATV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

333146:FACI RS08215
gene id: 333146:FACI_RS08215
uniprot id: S0ATT4
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS03475
gene id: 333146:FACI_RS03475
uniprot id: S0ARC6
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

333146:FACI RS05635
gene id: 333146:FACI_RS05635
uniprot id: S0ASQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

333146:FACI RS07605
gene id: 333146:FACI_RS07605
uniprot id: S0ATP8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

333146:FACI RS03620
gene id: 333146:FACI_RS03620
uniprot id: S0APN4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

333146:FACI RS07515
gene id: 333146:FACI_RS07515
uniprot id: S0ATL8
names: Similarity
messages: Belongs to the AAA ATPase family.

333146:FACI RS04675
gene id: 333146:FACI_RS04675
uniprot id: S0APU3
names: Similarity
messages: Belongs to the GcvT family.

333146:FACI RS05055
gene id: 333146:FACI_RS05055
uniprot id: S0ASB4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

333146:FACI RS08240
gene id: 333146:FACI_RS08240
uniprot id: S0ATT6
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS03295
gene id: 333146:FACI_RS03295
uniprot id: S0AR79
names: Similarity
messages: Belongs to the acylphosphatase family.

333146:FACI RS06775
gene id: 333146:FACI_RS06775
uniprot id: S0AQ03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

333146:FACI RS06985
gene id: 333146:FACI_RS06985
uniprot id: S0ARH2
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS06220
gene id: 333146:FACI_RS06220
uniprot id: S0AR30
names: Similarity
messages: Belongs to the MCM family.

333146:FACI RS05995
gene id: 333146:FACI_RS05995
uniprot id: S0API3
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

333146:FACI RS07615
gene id: 333146:FACI_RS07615
uniprot id: S0ARB2
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

333146:FACI RS05780
gene id: 333146:FACI_RS05780
uniprot id: S0ASY4
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

333146:FACI RS03070
gene id: 333146:FACI_RS03070
uniprot id: S0AR77
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

333146:FACI RS06910
gene id: 333146:FACI_RS06910
uniprot id: S0AR00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

333146:FACI RS05890
gene id: 333146:FACI_RS05890
uniprot id: S0AT04
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

333146:FACI RS06240
gene id: 333146:FACI_RS06240
uniprot id: S0AQK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

333146:FACI RS02865
gene id: 333146:FACI_RS02865
uniprot id: S0ANS9
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS08525
gene id: 333146:FACI_RS08525
uniprot id: S0ASC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

333146:FACI RS01185
gene id: 333146:FACI_RS01185
uniprot id: S0AMJ3
names: Similarity
messages: Belongs to the Nth/MutY family.

333146:FACI RS03755
gene id: 333146:FACI_RS03755
uniprot id: S0ARM7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

333146:FACI RS09230
gene id: 333146:FACI_RS09230
uniprot id: S0ARL4
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.

333146:FACI RS02600
gene id: 333146:FACI_RS02600
uniprot id: S0AMJ5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

333146:FACI RS07650
gene id: 333146:FACI_RS07650
uniprot id: S0AQJ2
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

333146:FACI RS01120
gene id: 333146:FACI_RS01120
uniprot id: S0AN79
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

333146:FACI RS05765
gene id: 333146:FACI_RS05765
uniprot id: S0AQB7
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

333146:FACI RS03320
gene id: 333146:FACI_RS03320
uniprot id: S0AR84
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

333146:FACI RS08800
gene id: 333146:FACI_RS08800
uniprot id: S0ASJ0
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

333146:FACI RS03450
gene id: 333146:FACI_RS03450
uniprot id: S0ARB7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

333146:FACI RS04745
gene id: 333146:FACI_RS04745
uniprot id: S0AS41
names: Similarity
messages: Belongs to the glutamine synthetase family.

333146:FACI RS08280
gene id: 333146:FACI_RS08280
uniprot id: S0ATV5
names: Similarity
messages: Belongs to the UPF0235 family.

333146:FACI RS07215
gene id: 333146:FACI_RS07215
uniprot id: S0ATJ0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

333146:FACI RS03145
gene id: 333146:FACI_RS03145
uniprot id: S0APC2
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

333146:FACI RS03725
gene id: 333146:FACI_RS03725
uniprot id: S0ARH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

333146:FACI RS05220
gene id: 333146:FACI_RS05220
uniprot id: S0AQH5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

333146:FACI RS02005
gene id: 333146:FACI_RS02005
uniprot id: S0AQQ1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

333146:FACI RS09435
gene id: 333146:FACI_RS09435
uniprot id: S0ASC1
names: Similarity
messages: Belongs to the UPF0145 family.

333146:FACI RS01965
gene id: 333146:FACI_RS01965
uniprot id: S0AM66
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

333146:FACI RS08985
gene id: 333146:FACI_RS08985
uniprot id: S0AU10
names: Similarity
messages: Belongs to the SfsA family.

333146:FACI RS04625
gene id: 333146:FACI_RS04625
uniprot id: S0AQ84
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

333146:FACI RS06410
gene id: 333146:FACI_RS06410
uniprot id: S0AQQ5
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

333146:FACI RS00865
gene id: 333146:FACI_RS00865
uniprot id: S0AN28
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

333146:FACI RS07570
gene id: 333146:FACI_RS07570
uniprot id: S0ARA3
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.

333146:FACI RS06650
gene id: 333146:FACI_RS06650
uniprot id: S0APY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

333146:FACI RS05650
gene id: 333146:FACI_RS05650
uniprot id: S0APB8
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

333146:FACI RS04840
gene id: 333146:FACI_RS04840
uniprot id: S0AQB5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

333146:FACI RS02315
gene id: 333146:FACI_RS02315
uniprot id: S0AQJ5
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

333146:FACI RS03370
gene id: 333146:FACI_RS03370
uniprot id: S0AR94
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS02495
gene id: 333146:FACI_RS02495
uniprot id: S0ANZ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

333146:FACI RS06665
gene id: 333146:FACI_RS06665
uniprot id: S0AQW2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

333146:FACI RS05190
gene id: 333146:FACI_RS05190
uniprot id: S0AQ13
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS03645
gene id: 333146:FACI_RS03645
uniprot id: S0APP1
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS00045
gene id: 333146:FACI_RS00045
uniprot id: S0AP67
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

333146:FACI RS01470
gene id: 333146:FACI_RS01470
uniprot id: S0ANG2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

333146:FACI RS00565
gene id: 333146:FACI_RS00565
uniprot id: S0AMW4
names: Similarity
messages: Belongs to the glutamine synthetase family.

333146:FACI RS05460
gene id: 333146:FACI_RS05460
uniprot id: S0ASQ7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

333146:FACI RS02490
gene id: 333146:FACI_RS02490
uniprot id: S0ANI9
names: Caution
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

333146:FACI RS03945
gene id: 333146:FACI_RS03945
uniprot id: S0ANF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

333146:FACI RS05505
gene id: 333146:FACI_RS05505
uniprot id: S0AP88
names: Similarity
messages: Belongs to the HAM1 NTPase family.

333146:FACI RS02485
gene id: 333146:FACI_RS02485
uniprot id: S0AQX1
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

333146:FACI RS03065
gene id: 333146:FACI_RS03065
uniprot id: S0AR18
names: Similarity
messages: Belongs to the arsA ATPase family.

333146:FACI RS02880
gene id: 333146:FACI_RS02880
uniprot id: S0AQY3
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

333146:FACI RS03330
gene id: 333146:FACI_RS03330
uniprot id: S0AP21
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

333146:FACI RS06305
gene id: 333146:FACI_RS06305
uniprot id: S0AT76
names: Similarity
messages: Belongs to the peptidase S66 family.

333146:FACI RS08145
gene id: 333146:FACI_RS08145
uniprot id: S0ARL3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

333146:FACI RS05135
gene id: 333146:FACI_RS05135
uniprot id: S0ASD0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

333146:FACI RS03460
gene id: 333146:FACI_RS03460
uniprot id: S0AP50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

333146:FACI RS06280
gene id: 333146:FACI_RS06280
uniprot id: S0AT72
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

333146:FACI RS07870
gene id: 333146:FACI_RS07870
uniprot id: S0ATS0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

333146:FACI RS04880
gene id: 333146:FACI_RS04880
uniprot id: S0AS75
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

333146:FACI RS02535
gene id: 333146:FACI_RS02535
uniprot id: S0AQX9
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

333146:FACI RS06340
gene id: 333146:FACI_RS06340
uniprot id: S0AR52
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

333146:FACI RS09370
gene id: 333146:FACI_RS09370
uniprot id: S0ASV0
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

333146:FACI RS03575
gene id: 333146:FACI_RS03575
uniprot id: S0AN56
names: Similarity
messages: Belongs to the ComB family.

333146:FACI RS01635
gene id: 333146:FACI_RS01635
uniprot id: S0AQK6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

333146:FACI RS05835
gene id: 333146:FACI_RS05835
uniprot id: S0ASV2
names: Subcellular Location Annotation
messages: Membrane

333146:FACI RS06230
gene id: 333146:FACI_RS06230
uniprot id: S0AT64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

333146:FACI RS05685
gene id: 333146:FACI_RS05685
uniprot id: S0ASR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

333146:FACI RS09840
gene id: 333146:FACI_RS09840
uniprot id: S0AR51
names: Similarity
messages: Belongs to the ice-binding protein family.

333146:FACI RS05830
gene id: 333146:FACI_RS05830
uniprot id: S0ASZ1
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.