323259:MHUN RS11895
gene id: 323259:MHUN_RS11895
uniprot id: Q2FU59
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

323259:MHUN RS05905
gene id: 323259:MHUN_RS05905
uniprot id: Q2FPD4
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

323259:MHUN RS11270
gene id: 323259:MHUN_RS11270
uniprot id: Q2FRN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

323259:MHUN RS08330
gene id: 323259:MHUN_RS08330
uniprot id: Q2FQX9
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS12515
gene id: 323259:MHUN_RS12515
uniprot id: Q2FT79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

323259:MHUN RS00855
gene id: 323259:MHUN_RS00855
uniprot id: Q2FMX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

323259:MHUN RS16005
gene id: 323259:MHUN_RS16005
uniprot id: Q2FRS4
names: Similarity
messages: Belongs to the acylphosphatase family.

323259:MHUN RS16510
gene id: 323259:MHUN_RS16510
uniprot id: Q2FNE9
names: Similarity
messages: Belongs to the acylphosphatase family.

323259:MHUN RS13065
gene id: 323259:MHUN_RS13065
uniprot id: Q2FS32
names: Similarity
messages: Belongs to the P(II) protein family.

323259:MHUN RS02965
gene id: 323259:MHUN_RS02965
uniprot id: Q2FLF0
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

323259:MHUN RS13705
gene id: 323259:MHUN_RS13705
uniprot id: Q2FTX7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

323259:MHUN RS02440
gene id: 323259:MHUN_RS02440
uniprot id: Q2FMN3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

323259:MHUN RS11105
gene id: 323259:MHUN_RS11105
uniprot id: Q2FN66
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

323259:MHUN RS00300
gene id: 323259:MHUN_RS00300
uniprot id: Q2FPJ8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

323259:MHUN RS00725
gene id: 323259:MHUN_RS00725
uniprot id: Q2FMZ1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.

323259:MHUN RS07980
gene id: 323259:MHUN_RS07980
uniprot id: Q2FP36
names: Similarity
messages: Belongs to the UPF0047 family.

323259:MHUN RS12925
gene id: 323259:MHUN_RS12925
uniprot id: Q2FU09
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

323259:MHUN RS00390
gene id: 323259:MHUN_RS00390
uniprot id: Q2FLN5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

323259:MHUN RS00275
gene id: 323259:MHUN_RS00275
uniprot id: Q2FQ27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

323259:MHUN RS14275
gene id: 323259:MHUN_RS14275
uniprot id: Q2FNB9
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

323259:MHUN RS13625
gene id: 323259:MHUN_RS13625
uniprot id: Q2FSD2
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.

323259:MHUN RS12130
gene id: 323259:MHUN_RS12130
uniprot id: Q2FNB8
names: Similarity
messages: Belongs to the HepT RNase toxin family.

323259:MHUN RS15095
gene id: 323259:MHUN_RS15095
uniprot id: Q2FTP1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

323259:MHUN RS09450
gene id: 323259:MHUN_RS09450
uniprot id: Q2FKY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

323259:MHUN RS01875
gene id: 323259:MHUN_RS01875
uniprot id: Q2FMI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

323259:MHUN RS12910
gene id: 323259:MHUN_RS12910
uniprot id: Q2FU15
names: Similarity
messages: Belongs to the peptidase S8 family.

323259:MHUN RS13435
gene id: 323259:MHUN_RS13435
uniprot id: Q2FRX2
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

323259:MHUN RS01110
gene id: 323259:MHUN_RS01110
uniprot id: Q2FN00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

323259:MHUN RS15520
gene id: 323259:MHUN_RS15520
uniprot id: Q2FSC7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: Consists of two subunits, CofG and CofH.

323259:MHUN RS05160
gene id: 323259:MHUN_RS05160
uniprot id: Q2FQU2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

323259:MHUN RS04425
gene id: 323259:MHUN_RS04425
uniprot id: Q2FQL8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

323259:MHUN RS05280
gene id: 323259:MHUN_RS05280
uniprot id: Q2FQM6
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

323259:MHUN RS03605
gene id: 323259:MHUN_RS03605
uniprot id: Q2FQG1
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).

323259:MHUN RS11610
gene id: 323259:MHUN_RS11610
uniprot id: Q2FSG3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

323259:MHUN RS09230
gene id: 323259:MHUN_RS09230
uniprot id: Q2FQE2
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

323259:MHUN RS14995
gene id: 323259:MHUN_RS14995
uniprot id: Q2FS43
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

323259:MHUN RS11285
gene id: 323259:MHUN_RS11285
uniprot id: Q2FRN1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Belongs to the MtrG family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

323259:MHUN RS09195
gene id: 323259:MHUN_RS09195
uniprot id: Q2FL51
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

323259:MHUN RS10110
gene id: 323259:MHUN_RS10110
uniprot id: Q2FMC1
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS11735
gene id: 323259:MHUN_RS11735
uniprot id: Q2FTS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

323259:MHUN RS16815
gene id: 323259:MHUN_RS16815
uniprot id: Q2FRR2
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

323259:MHUN RS15160
gene id: 323259:MHUN_RS15160
uniprot id: Q2FT97
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

323259:MHUN RS15260
gene id: 323259:MHUN_RS15260
uniprot id: Q2FRT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

323259:MHUN RS06515
gene id: 323259:MHUN_RS06515
uniprot id: Q2FLX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

323259:MHUN RS05865
gene id: 323259:MHUN_RS05865
uniprot id: Q2FUA5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

323259:MHUN RS11240
gene id: 323259:MHUN_RS11240
uniprot id: Q2FSU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

323259:MHUN RS04725
gene id: 323259:MHUN_RS04725
uniprot id: Q2FQ93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

323259:MHUN RS14520
gene id: 323259:MHUN_RS14520
uniprot id: Q2FSK3
names: Similarity
messages: Belongs to the HsdR family.

323259:MHUN RS08435
gene id: 323259:MHUN_RS08435
uniprot id: Q2FRG4
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS07735
gene id: 323259:MHUN_RS07735
uniprot id: Q2FNX7
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS13185
gene id: 323259:MHUN_RS13185
uniprot id: Q2FSE6
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

323259:MHUN RS06365
gene id: 323259:MHUN_RS06365
uniprot id: Q2FNI8
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS16060
gene id: 323259:MHUN_RS16060
uniprot id: Q2FS12
names: Similarity
messages: Belongs to the UDPGP type 2 family.

323259:MHUN RS09905
gene id: 323259:MHUN_RS09905
uniprot id: Q2FRB3
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS11410
gene id: 323259:MHUN_RS11410
uniprot id: Q2FSX5
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS10180
gene id: 323259:MHUN_RS10180
uniprot id: Q2FRM3
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS05045
gene id: 323259:MHUN_RS05045
uniprot id: Q2FPE4
names: Similarity
messages: Belongs to the hemerythrin family.

323259:MHUN RS04275
gene id: 323259:MHUN_RS04275
uniprot id: Q2FMV5
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

323259:MHUN RS05500
gene id: 323259:MHUN_RS05500
uniprot id: Q2FR36
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.

323259:MHUN RS11145
gene id: 323259:MHUN_RS11145
uniprot id: Q2FSN0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

323259:MHUN RS08135
gene id: 323259:MHUN_RS08135
uniprot id: Q2FRJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

323259:MHUN RS03460
gene id: 323259:MHUN_RS03460
uniprot id: Q2FQ31
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

323259:MHUN RS11705
gene id: 323259:MHUN_RS11705
uniprot id: Q2FU92
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

323259:MHUN RS12740
gene id: 323259:MHUN_RS12740
uniprot id: Q2FRU6
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

323259:MHUN RS12905
gene id: 323259:MHUN_RS12905
uniprot id: Q2FU16
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

323259:MHUN RS17175
gene id: 323259:MHUN_RS17175
uniprot id: Q2FRC3
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

323259:MHUN RS13470
gene id: 323259:MHUN_RS13470
uniprot id: Q2FU35
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS17430
gene id: 323259:MHUN_RS17430
uniprot id: Q2FP17
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

323259:MHUN RS06150
gene id: 323259:MHUN_RS06150
uniprot id: Q2FNP7
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS12895
gene id: 323259:MHUN_RS12895
uniprot id: Q2FN74
names: Similarity
messages: Belongs to the DMRL synthase family.

323259:MHUN RS01150
gene id: 323259:MHUN_RS01150
uniprot id: Q2FMJ3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS06085
gene id: 323259:MHUN_RS06085
uniprot id: Q2FPB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

323259:MHUN RS03455
gene id: 323259:MHUN_RS03455
uniprot id: Q2FQ32
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

323259:MHUN RS12165
gene id: 323259:MHUN_RS12165
uniprot id: Q2FNB1
names: Similarity
messages: Belongs to the peptidase M24B family.

323259:MHUN RS00110
gene id: 323259:MHUN_RS00110
uniprot id: Q2FLH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

323259:MHUN RS15940
gene id: 323259:MHUN_RS15940
uniprot id: Q2FT49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

323259:MHUN RS16045
gene id: 323259:MHUN_RS16045
uniprot id: Q2FRR9
names: Function
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.

323259:MHUN RS07805
gene id: 323259:MHUN_RS07805
uniprot id: Q2FNQ8
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

323259:MHUN RS01335
gene id: 323259:MHUN_RS01335
uniprot id: Q2FLR7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS13485
gene id: 323259:MHUN_RS13485
uniprot id: Q2FU29
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS00900
gene id: 323259:MHUN_RS00900
uniprot id: Q2FPG8
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS08370
gene id: 323259:MHUN_RS08370
uniprot id: Q2FQX2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

323259:MHUN RS15220
gene id: 323259:MHUN_RS15220
uniprot id: Q2FTC8
names: Similarity
messages: Belongs to the SUI1 family.

323259:MHUN RS00785
gene id: 323259:MHUN_RS00785
uniprot id: Q2FPH4
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

323259:MHUN RS06185
gene id: 323259:MHUN_RS06185
uniprot id: Q2FNK3
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

323259:MHUN RS12900
gene id: 323259:MHUN_RS12900
uniprot id: Q2FU18
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

323259:MHUN RS04020
gene id: 323259:MHUN_RS04020
uniprot id: Q2FPB2
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS05940
gene id: 323259:MHUN_RS05940
uniprot id: Q2FPC7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

323259:MHUN RS01530
gene id: 323259:MHUN_RS01530
uniprot id: Q2FMY4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS00680
gene id: 323259:MHUN_RS00680
uniprot id: Q2FQP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

323259:MHUN RS16765
gene id: 323259:MHUN_RS16765
uniprot id: Q2FRU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

323259:MHUN RS11625
gene id: 323259:MHUN_RS11625
uniprot id: Q2FSG6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

323259:MHUN RS03335
gene id: 323259:MHUN_RS03335
uniprot id: Q2FLJ1
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS04965
gene id: 323259:MHUN_RS04965
uniprot id: Q2FQJ9
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

323259:MHUN RS04795
gene id: 323259:MHUN_RS04795
uniprot id: Q2FN17
names: Similarity
messages: Belongs to the MtxX family.

323259:MHUN RS19205
gene id: 323259:MHUN_RS19205
uniprot id: Q2FNN7
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

323259:MHUN RS01695
gene id: 323259:MHUN_RS01695
uniprot id: Q2FMU1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS05415
gene id: 323259:MHUN_RS05415
uniprot id: Q2FQ49
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

323259:MHUN RS11585
gene id: 323259:MHUN_RS11585
uniprot id: Q2FTU8
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS06930
gene id: 323259:MHUN_RS06930
uniprot id: Q2FNY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

323259:MHUN RS05190
gene id: 323259:MHUN_RS05190
uniprot id: Q2FQT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

323259:MHUN RS10240
gene id: 323259:MHUN_RS10240
uniprot id: Q2FM99
names: Similarity
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

323259:MHUN RS04805
gene id: 323259:MHUN_RS04805
uniprot id: Q2FN13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

323259:MHUN RS07000
gene id: 323259:MHUN_RS07000
uniprot id: Q2FNW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

323259:MHUN RS05260
gene id: 323259:MHUN_RS05260
uniprot id: Q2FPK9
names: Similarity
messages: Belongs to the AOR/FOR family.

323259:MHUN RS15100
gene id: 323259:MHUN_RS15100
uniprot id: Q2FTP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

323259:MHUN RS06610
gene id: 323259:MHUN_RS06610
uniprot id: Q2FPM6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

323259:MHUN RS08570
gene id: 323259:MHUN_RS08570
uniprot id: Q2FMD4
names: Similarity
messages: Belongs to the P(II) protein family.

323259:MHUN RS12050
gene id: 323259:MHUN_RS12050
uniprot id: Q2FSY4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

323259:MHUN RS16595
gene id: 323259:MHUN_RS16595
uniprot id: Q2FUK7
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

323259:MHUN RS13085
gene id: 323259:MHUN_RS13085
uniprot id: Q2FS33
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

323259:MHUN RS06055
gene id: 323259:MHUN_RS06055
uniprot id: Q2FP82
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

323259:MHUN RS15295
gene id: 323259:MHUN_RS15295
uniprot id: Q2FRS8
names: Similarity
messages: Belongs to the UPF0175 family.

323259:MHUN RS00820
gene id: 323259:MHUN_RS00820
uniprot id: Q2FQA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

323259:MHUN RS03610
gene id: 323259:MHUN_RS03610
uniprot id: Q2FQG0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhD family.
messages: Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex.

323259:MHUN RS11885
gene id: 323259:MHUN_RS11885
uniprot id: Q2FU62
names: Similarity
messages: Belongs to the SDO1/SBDS family.

323259:MHUN RS09500
gene id: 323259:MHUN_RS09500
uniprot id: Q2FKS6
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS12730
gene id: 323259:MHUN_RS12730
uniprot id: Q2FRU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.

323259:MHUN RS12235
gene id: 323259:MHUN_RS12235
uniprot id: Q2FSL1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

323259:MHUN RS12075
gene id: 323259:MHUN_RS12075
uniprot id: Q2FSY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Membrane

323259:MHUN RS05105
gene id: 323259:MHUN_RS05105
uniprot id: Q2FQV5
names: Similarity
messages: Belongs to the peptidase U62 family.

323259:MHUN RS12970
gene id: 323259:MHUN_RS12970
uniprot id: Q2FU48
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

323259:MHUN RS00935
gene id: 323259:MHUN_RS00935
uniprot id: Q2FPF1
names: Similarity
messages: Belongs to the GrpE family.

323259:MHUN RS01820
gene id: 323259:MHUN_RS01820
uniprot id: Q2FLA5
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

323259:MHUN RS05085
gene id: 323259:MHUN_RS05085
uniprot id: Q2FPD8
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

323259:MHUN RS14750
gene id: 323259:MHUN_RS14750
uniprot id: Q2FU77
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

323259:MHUN RS09390
gene id: 323259:MHUN_RS09390
uniprot id: Q2FKT9
names: Similarity
messages: Belongs to the LeuD family. LeuD type 2 subfamily.

323259:MHUN RS00840
gene id: 323259:MHUN_RS00840
uniprot id: Q2FQA1
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS12865
gene id: 323259:MHUN_RS12865
uniprot id: Q2FN80
names: Similarity
messages: Belongs to the MoaB/Mog family.

323259:MHUN RS05550
gene id: 323259:MHUN_RS05550
uniprot id: Q2FPN0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

323259:MHUN RS01090
gene id: 323259:MHUN_RS01090
uniprot id: Q2FPU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

323259:MHUN RS18700
gene id: 323259:MHUN_RS18700
uniprot id: Q2FRD9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

323259:MHUN RS08365
gene id: 323259:MHUN_RS08365
uniprot id: Q2FQX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

323259:MHUN RS05035
gene id: 323259:MHUN_RS05035
uniprot id: Q2FPE7
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

323259:MHUN RS11675
gene id: 323259:MHUN_RS11675
uniprot id: Q2FT30
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

323259:MHUN RS02280
gene id: 323259:MHUN_RS02280
uniprot id: Q2FQH4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

323259:MHUN RS14615
gene id: 323259:MHUN_RS14615
uniprot id: Q2FT21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

323259:MHUN RS01510
gene id: 323259:MHUN_RS01510
uniprot id: Q2FMX9
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

323259:MHUN RS03590
gene id: 323259:MHUN_RS03590
uniprot id: Q2FQG6
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS00420
gene id: 323259:MHUN_RS00420
uniprot id: Q2FQN7
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

323259:MHUN RS00285
gene id: 323259:MHUN_RS00285
uniprot id: Q2FPK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

323259:MHUN RS01225
gene id: 323259:MHUN_RS01225
uniprot id: Q2FMX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

323259:MHUN RS15140
gene id: 323259:MHUN_RS15140
uniprot id: Q2FTN5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

323259:MHUN RS01045
gene id: 323259:MHUN_RS01045
uniprot id: Q2FLA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

323259:MHUN RS10425
gene id: 323259:MHUN_RS10425
uniprot id: Q2FMF7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS15810
gene id: 323259:MHUN_RS15810
uniprot id: Q2FSA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

323259:MHUN RS16390
gene id: 323259:MHUN_RS16390
uniprot id: Q2FUM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

323259:MHUN RS15785
gene id: 323259:MHUN_RS15785
uniprot id: Q2FS92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

323259:MHUN RS09590
gene id: 323259:MHUN_RS09590
uniprot id: Q2FKZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

323259:MHUN RS10075
gene id: 323259:MHUN_RS10075
uniprot id: Q2FRH4
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

323259:MHUN RS06195
gene id: 323259:MHUN_RS06195
uniprot id: Q2FP53
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

323259:MHUN RS08150
gene id: 323259:MHUN_RS08150
uniprot id: Q2FRI6
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

323259:MHUN RS05920
gene id: 323259:MHUN_RS05920
uniprot id: Q2FPD1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).

323259:MHUN RS11255
gene id: 323259:MHUN_RS11255
uniprot id: Q2FRN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

323259:MHUN RS01270
gene id: 323259:MHUN_RS01270
uniprot id: Q2FUE4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS14820
gene id: 323259:MHUN_RS14820
uniprot id: Q2FSR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

323259:MHUN RS12080
gene id: 323259:MHUN_RS12080
uniprot id: Q2FSY1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

323259:MHUN RS06730
gene id: 323259:MHUN_RS06730
uniprot id: Q2FP25
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

323259:MHUN RS13560
gene id: 323259:MHUN_RS13560
uniprot id: Q2FSV8
names: Similarity
messages: Belongs to the archaeal-type GPI family.

323259:MHUN RS05505
gene id: 323259:MHUN_RS05505
uniprot id: Q2FR34
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

323259:MHUN RS08575
gene id: 323259:MHUN_RS08575
uniprot id: Q2FRH1
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

323259:MHUN RS04650
gene id: 323259:MHUN_RS04650
uniprot id: Q2FQ01
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

323259:MHUN RS03470
gene id: 323259:MHUN_RS03470
uniprot id: Q2FPX5
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS13620
gene id: 323259:MHUN_RS13620
uniprot id: Q2FSD4
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

323259:MHUN RS04355
gene id: 323259:MHUN_RS04355
uniprot id: Q2FUA8
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

323259:MHUN RS08925
gene id: 323259:MHUN_RS08925
uniprot id: Q2FQY4
names: Similarity
messages: Belongs to the UPF0147 family.

323259:MHUN RS11840
gene id: 323259:MHUN_RS11840
uniprot id: Q2FT61
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

323259:MHUN RS04310
gene id: 323259:MHUN_RS04310
uniprot id: Q2FMU6
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

323259:MHUN RS15775
gene id: 323259:MHUN_RS15775
uniprot id: Q2FS95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

323259:MHUN RS01500
gene id: 323259:MHUN_RS01500
uniprot id: Q2FQQ8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS11615
gene id: 323259:MHUN_RS11615
uniprot id: Q2FSH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

323259:MHUN RS05805
gene id: 323259:MHUN_RS05805
uniprot id: Q2FPQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

323259:MHUN RS16555
gene id: 323259:MHUN_RS16555
uniprot id: Q2FUL4
names: Subunit
messages: Homotetramer.

323259:MHUN RS06870
gene id: 323259:MHUN_RS06870
uniprot id: Q2FNM4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

323259:MHUN RS01690
gene id: 323259:MHUN_RS01690
uniprot id: Q2FMU3
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS06065
gene id: 323259:MHUN_RS06065
uniprot id: Q2FPC2
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

323259:MHUN RS05285
gene id: 323259:MHUN_RS05285
uniprot id: Q2FQM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group I subfamily.
messages: Cytoplasm
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

323259:MHUN RS05800
gene id: 323259:MHUN_RS05800
uniprot id: Q2FLB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

323259:MHUN RS12090
gene id: 323259:MHUN_RS12090
uniprot id: Q2FTH0
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

323259:MHUN RS04715
gene id: 323259:MHUN_RS04715
uniprot id: Q2FQ95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

323259:MHUN RS13040
gene id: 323259:MHUN_RS13040
uniprot id: Q2FSN9
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

323259:MHUN RS16790
gene id: 323259:MHUN_RS16790
uniprot id: Q2FRU2
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

323259:MHUN RS17290
gene id: 323259:MHUN_RS17290
uniprot id: Q2FP24
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

323259:MHUN RS13150
gene id: 323259:MHUN_RS13150
uniprot id: Q2FNC9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

323259:MHUN RS01850
gene id: 323259:MHUN_RS01850
uniprot id: Q2FLA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

323259:MHUN RS14700
gene id: 323259:MHUN_RS14700
uniprot id: Q2FTI5
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS13080
gene id: 323259:MHUN_RS13080
uniprot id: Q2FS35
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

323259:MHUN RS05925
gene id: 323259:MHUN_RS05925
uniprot id: Q2FPD0
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

323259:MHUN RS14975
gene id: 323259:MHUN_RS14975
uniprot id: Q2FTM8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

323259:MHUN RS06845
gene id: 323259:MHUN_RS06845
uniprot id: Q2FNZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0182 family.
messages: Cell membrane

323259:MHUN RS01115
gene id: 323259:MHUN_RS01115
uniprot id: Q2FMZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

323259:MHUN RS15350
gene id: 323259:MHUN_RS15350
uniprot id: Q2FS75
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

323259:MHUN RS03215
gene id: 323259:MHUN_RS03215
uniprot id: Q2FPJ6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

323259:MHUN RS09675
gene id: 323259:MHUN_RS09675
uniprot id: Q2FQQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

323259:MHUN RS09110
gene id: 323259:MHUN_RS09110
uniprot id: Q2FL36
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

323259:MHUN RS15145
gene id: 323259:MHUN_RS15145
uniprot id: Q2FTA2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

323259:MHUN RS10470
gene id: 323259:MHUN_RS10470
uniprot id: Q2FME4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

323259:MHUN RS17635
gene id: 323259:MHUN_RS17635
uniprot id: Q2FLU8
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

323259:MHUN RS13725
gene id: 323259:MHUN_RS13725
uniprot id: Q2FS89
names: Similarity
messages: Belongs to the HisA/HisF family.

323259:MHUN RS09265
gene id: 323259:MHUN_RS09265
uniprot id: Q2FM53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

323259:MHUN RS04785
gene id: 323259:MHUN_RS04785
uniprot id: Q2FQR4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

323259:MHUN RS10350
gene id: 323259:MHUN_RS10350
uniprot id: Q2FRL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

323259:MHUN RS06760
gene id: 323259:MHUN_RS06760
uniprot id: Q2FKQ9
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS08310
gene id: 323259:MHUN_RS08310
uniprot id: Q2FRI5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

323259:MHUN RS11690
gene id: 323259:MHUN_RS11690
uniprot id: Q2FT35
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

323259:MHUN RS05115
gene id: 323259:MHUN_RS05115
uniprot id: Q2FQV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.

323259:MHUN RS12965
gene id: 323259:MHUN_RS12965
uniprot id: Q2FU50
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

323259:MHUN RS05525
gene id: 323259:MHUN_RS05525
uniprot id: Q2FPN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

323259:MHUN RS10830
gene id: 323259:MHUN_RS10830
uniprot id: Q2FM88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

323259:MHUN RS09515
gene id: 323259:MHUN_RS09515
uniprot id: Q2FKT3
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

323259:MHUN RS01685
gene id: 323259:MHUN_RS01685
uniprot id: Q2FMU4
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS01665
gene id: 323259:MHUN_RS01665
uniprot id: Q2FLF5
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS13360
gene id: 323259:MHUN_RS13360
uniprot id: Q2FTL0
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

323259:MHUN RS15975
gene id: 323259:MHUN_RS15975
uniprot id: Q2FSJ3
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

323259:MHUN RS05855
gene id: 323259:MHUN_RS05855
uniprot id: Q2FPP2
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

323259:MHUN RS03970
gene id: 323259:MHUN_RS03970
uniprot id: Q2FN31
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS10820
gene id: 323259:MHUN_RS10820
uniprot id: Q2FM90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

323259:MHUN RS15340
gene id: 323259:MHUN_RS15340
uniprot id: Q2FS73
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS12780
gene id: 323259:MHUN_RS12780
uniprot id: Q2FSR3
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.

323259:MHUN RS17240
gene id: 323259:MHUN_RS17240
uniprot id: Q2FQT7
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

323259:MHUN RS05345
gene id: 323259:MHUN_RS05345
uniprot id: Q2FPI0
names: Similarity
messages: Belongs to the UPF0111 family.

323259:MHUN RS07455
gene id: 323259:MHUN_RS07455
uniprot id: Q2FP69
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS02970
gene id: 323259:MHUN_RS02970
uniprot id: Q2FLE9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

323259:MHUN RS00610
gene id: 323259:MHUN_RS00610
uniprot id: Q2FLD9
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

323259:MHUN RS15085
gene id: 323259:MHUN_RS15085
uniprot id: Q2FTH3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

323259:MHUN RS17555
gene id: 323259:MHUN_RS17555
uniprot id: Q2FQI2
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS08195
gene id: 323259:MHUN_RS08195
uniprot id: Q2FL18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

323259:MHUN RS17310
gene id: 323259:MHUN_RS17310
uniprot id: Q2FNI7
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

323259:MHUN RS05275
gene id: 323259:MHUN_RS05275
uniprot id: Q2FQM7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

323259:MHUN RS11700
gene id: 323259:MHUN_RS11700
uniprot id: Q2FU93
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

323259:MHUN RS12135
gene id: 323259:MHUN_RS12135
uniprot id: Q2FNB7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

323259:MHUN RS12195
gene id: 323259:MHUN_RS12195
uniprot id: Q2FRZ1
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

323259:MHUN RS00905
gene id: 323259:MHUN_RS00905
uniprot id: Q2FLH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 2 family.
messages: Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

323259:MHUN RS09400
gene id: 323259:MHUN_RS09400
uniprot id: Q2FKU8
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

323259:MHUN RS11510
gene id: 323259:MHUN_RS11510
uniprot id: Q2FNE6
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: In Archaea the pyridoxal phosphate cofactor is not covalently bound to Lys but ligated by other amino acids.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

323259:MHUN RS05955
gene id: 323259:MHUN_RS05955
uniprot id: Q2FLY5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

323259:MHUN RS03365
gene id: 323259:MHUN_RS03365
uniprot id: Q2FLJ6
names: Function
messages: Part of a potassium transport system.

323259:MHUN RS08010
gene id: 323259:MHUN_RS08010
uniprot id: Q2FP35
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Membrane

323259:MHUN RS00920
gene id: 323259:MHUN_RS00920
uniprot id: Q2FLH0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS15375
gene id: 323259:MHUN_RS15375
uniprot id: Q2FU42
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

323259:MHUN RS01050
gene id: 323259:MHUN_RS01050
uniprot id: Q2FL99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

323259:MHUN RS00215
gene id: 323259:MHUN_RS00215
uniprot id: Q2FQD6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

323259:MHUN RS16115
gene id: 323259:MHUN_RS16115
uniprot id: Q2FTQ9
names: Similarity
messages: Belongs to the polysaccharide synthase family.

323259:MHUN RS07460
gene id: 323259:MHUN_RS07460
uniprot id: Q2FP68
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS00475
gene id: 323259:MHUN_RS00475
uniprot id: Q2FLD3
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

323259:MHUN RS06980
gene id: 323259:MHUN_RS06980
uniprot id: Q2FNW5
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

323259:MHUN RS12835
gene id: 323259:MHUN_RS12835
uniprot id: Q2FNA0
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

323259:MHUN RS15290
gene id: 323259:MHUN_RS15290
uniprot id: Q2FRS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

323259:MHUN RS13565
gene id: 323259:MHUN_RS13565
uniprot id: Q2FSW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

323259:MHUN RS04195
gene id: 323259:MHUN_RS04195
uniprot id: Q2FPG2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

323259:MHUN RS00290
gene id: 323259:MHUN_RS00290
uniprot id: Q2FPK0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

323259:MHUN RS17155
gene id: 323259:MHUN_RS17155
uniprot id: Q2FLP1
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS05755
gene id: 323259:MHUN_RS05755
uniprot id: Q2FLB8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

323259:MHUN RS11380
gene id: 323259:MHUN_RS11380
uniprot id: Q2FU73
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

323259:MHUN RS00980
gene id: 323259:MHUN_RS00980
uniprot id: Q2FMP2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS03960
gene id: 323259:MHUN_RS03960
uniprot id: Q2FN33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

323259:MHUN RS13630
gene id: 323259:MHUN_RS13630
uniprot id: Q2FSD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

323259:MHUN RS14365
gene id: 323259:MHUN_RS14365
uniprot id: Q2FTQ2
names: Similarity
messages: Belongs to the hemerythrin family.

323259:MHUN RS11580
gene id: 323259:MHUN_RS11580
uniprot id: Q2FTU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

323259:MHUN RS06525
gene id: 323259:MHUN_RS06525
uniprot id: Q2FM36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

323259:MHUN RS13195
gene id: 323259:MHUN_RS13195
uniprot id: Q2FSE4
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

323259:MHUN RS14930
gene id: 323259:MHUN_RS14930
uniprot id: Q2FRV7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

323259:MHUN RS00580
gene id: 323259:MHUN_RS00580
uniprot id: Q2FMT2
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

323259:MHUN RS12825
gene id: 323259:MHUN_RS12825
uniprot id: Q2FNA2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

323259:MHUN RS13130
gene id: 323259:MHUN_RS13130
uniprot id: Q2FND3
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS05270
gene id: 323259:MHUN_RS05270
uniprot id: Q2FPK3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.
messages: The N-terminal domain is an archaea-specific tRNA-editing domain that hydrolyzes incorrectly charged L-seryl-tRNA(Thr). Catalysis of tRNA editing is performed by the charged tRNA itself.

323259:MHUN RS06720
gene id: 323259:MHUN_RS06720
uniprot id: Q2FP29
names: Similarity
messages: Belongs to the pirin family.

323259:MHUN RS11440
gene id: 323259:MHUN_RS11440
uniprot id: Q2FSW9
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS01755
gene id: 323259:MHUN_RS01755
uniprot id: Q2FR39
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

323259:MHUN RS15280
gene id: 323259:MHUN_RS15280
uniprot id: Q2FRT1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

323259:MHUN RS03320
gene id: 323259:MHUN_RS03320
uniprot id: Q2FN41
names: Function
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

323259:MHUN RS03200
gene id: 323259:MHUN_RS03200
uniprot id: Q2FPJ2
names: Similarity
messages: Belongs to the tRNA(His) guanylyltransferase family.

323259:MHUN RS05300
gene id: 323259:MHUN_RS05300
uniprot id: Q2FQM9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

323259:MHUN RS06190
gene id: 323259:MHUN_RS06190
uniprot id: Q2FNK2
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

323259:MHUN RS02335
gene id: 323259:MHUN_RS02335
uniprot id: Q2FR28
names: Similarity
messages: Belongs to the UPF0285 family.

323259:MHUN RS08380
gene id: 323259:MHUN_RS08380
uniprot id: Q2FRE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

323259:MHUN RS02310
gene id: 323259:MHUN_RS02310
uniprot id: Q2FR24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

323259:MHUN RS01025
gene id: 323259:MHUN_RS01025
uniprot id: Q2FPT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

323259:MHUN RS10015
gene id: 323259:MHUN_RS10015
uniprot id: Q2FM65
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

323259:MHUN RS14775
gene id: 323259:MHUN_RS14775
uniprot id: Q2FS69
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

323259:MHUN RS08900
gene id: 323259:MHUN_RS08900
uniprot id: Q2FR07
names: Similarity
messages: Belongs to the UPF0173 family.

323259:MHUN RS03450
gene id: 323259:MHUN_RS03450
uniprot id: Q2FQ33
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

323259:MHUN RS02435
gene id: 323259:MHUN_RS02435
uniprot id: Q2FMN5
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS10745
gene id: 323259:MHUN_RS10745
uniprot id: Q2FME9
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

323259:MHUN RS15150
gene id: 323259:MHUN_RS15150
uniprot id: Q2FTA0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

323259:MHUN RS04880
gene id: 323259:MHUN_RS04880
uniprot id: Q2FQV9
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

323259:MHUN RS14990
gene id: 323259:MHUN_RS14990
uniprot id: Q2FS44
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 30S ribosomal subunit.

323259:MHUN RS14605
gene id: 323259:MHUN_RS14605
uniprot id: Q2FT22
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

323259:MHUN RS12025
gene id: 323259:MHUN_RS12025
uniprot id: Q2FRQ0
names: Similarity
messages: Belongs to the UPF0288 family.

323259:MHUN RS15120
gene id: 323259:MHUN_RS15120
uniprot id: Q2FTN3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

323259:MHUN RS05100
gene id: 323259:MHUN_RS05100
uniprot id: Q2FQV6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

323259:MHUN RS00590
gene id: 323259:MHUN_RS00590
uniprot id: Q2FMT0
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

323259:MHUN RS14765
gene id: 323259:MHUN_RS14765
uniprot id: Q2FU74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

323259:MHUN RS11860
gene id: 323259:MHUN_RS11860
uniprot id: Q2FT56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

323259:MHUN RS15540
gene id: 323259:MHUN_RS15540
uniprot id: Q2FSC2
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

323259:MHUN RS03615
gene id: 323259:MHUN_RS03615
uniprot id: Q2FQF9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CdhC family.
messages: Binds 1 [Ni-Fe-S] cluster.
messages: Monomer. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
messages: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex).

323259:MHUN RS06115
gene id: 323259:MHUN_RS06115
uniprot id: Q2FP45
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

323259:MHUN RS15175
gene id: 323259:MHUN_RS15175
uniprot id: Q2FT95
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

323259:MHUN RS03005
gene id: 323259:MHUN_RS03005
uniprot id: Q2FLE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

323259:MHUN RS17085
gene id: 323259:MHUN_RS17085
uniprot id: Q2FN52
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

323259:MHUN RS04215
gene id: 323259:MHUN_RS04215
uniprot id: Q2FPF8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS15115
gene id: 323259:MHUN_RS15115
uniprot id: Q2FTN4
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

323259:MHUN RS16110
gene id: 323259:MHUN_RS16110
uniprot id: Q2FTR0
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS11330
gene id: 323259:MHUN_RS11330
uniprot id: Q2FTY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

323259:MHUN RS00915
gene id: 323259:MHUN_RS00915
uniprot id: Q2FLG8
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS12885
gene id: 323259:MHUN_RS12885
uniprot id: Q2FN76
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

323259:MHUN RS04390
gene id: 323259:MHUN_RS04390
uniprot id: Q2FR71
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

323259:MHUN RS01015
gene id: 323259:MHUN_RS01015
uniprot id: Q2FMP5
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

323259:MHUN RS00470
gene id: 323259:MHUN_RS00470
uniprot id: Q2FLD4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS05055
gene id: 323259:MHUN_RS05055
uniprot id: Q2FPE2
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS05850
gene id: 323259:MHUN_RS05850
uniprot id: Q2FPP3
names: Subcellular Location Annotation
messages: Cytoplasm

323259:MHUN RS13020
gene id: 323259:MHUN_RS13020
uniprot id: Q2FSN8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

323259:MHUN RS00985
gene id: 323259:MHUN_RS00985
uniprot id: Q2FMP1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS04810
gene id: 323259:MHUN_RS04810
uniprot id: Q2FN18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

323259:MHUN RS10910
gene id: 323259:MHUN_RS10910
uniprot id: Q2FLM0
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS09645
gene id: 323259:MHUN_RS09645
uniprot id: Q2FQ67
names: Similarity
messages: Belongs to the thioesterase PaaI family.

323259:MHUN RS01190
gene id: 323259:MHUN_RS01190
uniprot id: Q2FR48
names: Similarity
messages: Belongs to the UPF0254 family.

323259:MHUN RS03245
gene id: 323259:MHUN_RS03245
uniprot id: Q2FN12
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

323259:MHUN RS17135
gene id: 323259:MHUN_RS17135
uniprot id: Q2FMR5
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

323259:MHUN RS13180
gene id: 323259:MHUN_RS13180
uniprot id: Q2FSE7
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

323259:MHUN RS00250
gene id: 323259:MHUN_RS00250
uniprot id: Q2FQC8
names: Similarity
messages: Belongs to the glutamate synthase family.

323259:MHUN RS07185
gene id: 323259:MHUN_RS07185
uniprot id: Q2FNT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

323259:MHUN RS06690
gene id: 323259:MHUN_RS06690
uniprot id: Q2FP99
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: CODH oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (possibly CooH).
messages: Homodimer.

323259:MHUN RS11590
gene id: 323259:MHUN_RS11590
uniprot id: Q2FTU6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

323259:MHUN RS04680
gene id: 323259:MHUN_RS04680
uniprot id: Q2FUH4
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS01490
gene id: 323259:MHUN_RS01490
uniprot id: Q2FQR1
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS15690
gene id: 323259:MHUN_RS15690
uniprot id: Q2FSQ3
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

323259:MHUN RS06210
gene id: 323259:MHUN_RS06210
uniprot id: Q2FP50
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

323259:MHUN RS15255
gene id: 323259:MHUN_RS15255
uniprot id: Q2FTC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

323259:MHUN RS14810
gene id: 323259:MHUN_RS14810
uniprot id: Q2FS66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

323259:MHUN RS01000
gene id: 323259:MHUN_RS01000
uniprot id: Q2FMN8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS16845
gene id: 323259:MHUN_RS16845
uniprot id: Q2FRR5
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

323259:MHUN RS13165
gene id: 323259:MHUN_RS13165
uniprot id: Q2FSF0
names: Caution
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

323259:MHUN RS00305
gene id: 323259:MHUN_RS00305
uniprot id: Q2FPJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

323259:MHUN RS13295
gene id: 323259:MHUN_RS13295
uniprot id: Q2FTL9
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

323259:MHUN RS05355
gene id: 323259:MHUN_RS05355
uniprot id: Q2FPI6
names: Similarity
messages: Belongs to the UPF0111 family.

323259:MHUN RS10440
gene id: 323259:MHUN_RS10440
uniprot id: Q2FMG0
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS12485
gene id: 323259:MHUN_RS12485
uniprot id: Q2FSZ9
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

323259:MHUN RS11065
gene id: 323259:MHUN_RS11065
uniprot id: Q2FN95
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

323259:MHUN RS05340
gene id: 323259:MHUN_RS05340
uniprot id: Q2FPI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

323259:MHUN RS08635
gene id: 323259:MHUN_RS08635
uniprot id: Q2FRF5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS08300
gene id: 323259:MHUN_RS08300
uniprot id: Q2FL30
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

323259:MHUN RS06240
gene id: 323259:MHUN_RS06240
uniprot id: Q2FM26
names: Similarity
messages: Belongs to the UPF0175 family.

323259:MHUN RS04885
gene id: 323259:MHUN_RS04885
uniprot id: Q2FN60
names: Similarity
messages: Belongs to the HypE family.

323259:MHUN RS03445
gene id: 323259:MHUN_RS03445
uniprot id: Q2FQ36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

323259:MHUN RS11870
gene id: 323259:MHUN_RS11870
uniprot id: Q2FT54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

323259:MHUN RS04815
gene id: 323259:MHUN_RS04815
uniprot id: Q2FN16
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

323259:MHUN RS16530
gene id: 323259:MHUN_RS16530
uniprot id: Q2FNH1
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS10480
gene id: 323259:MHUN_RS10480
uniprot id: Q2FME6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

323259:MHUN RS08975
gene id: 323259:MHUN_RS08975
uniprot id: Q2FLK9
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS04655
gene id: 323259:MHUN_RS04655
uniprot id: Q2FQ00
names: Similarity
messages: Belongs to the RuvC family.

323259:MHUN RS07795
gene id: 323259:MHUN_RS07795
uniprot id: Q2FNR0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

323259:MHUN RS02840
gene id: 323259:MHUN_RS02840
uniprot id: Q2FLQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0316 family.
messages: Cell membrane

323259:MHUN RS07810
gene id: 323259:MHUN_RS07810
uniprot id: Q2FNQ7
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Homodimer.

323259:MHUN RS08935
gene id: 323259:MHUN_RS08935
uniprot id: Q2FQY7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

323259:MHUN RS00160
gene id: 323259:MHUN_RS00160
uniprot id: Q2FQF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

323259:MHUN RS04345
gene id: 323259:MHUN_RS04345
uniprot id: Q2FUB2
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway (PubMed:23200110). ATP is the best phosphate donor. Can be replaced with UTP, with lower efficiency (PubMed:23200110).

323259:MHUN RS12775
gene id: 323259:MHUN_RS12775
uniprot id: Q2FSR4
names: Similarity
messages: Belongs to the LarC family.

323259:MHUN RS11890
gene id: 323259:MHUN_RS11890
uniprot id: Q2FU60
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

323259:MHUN RS03340
gene id: 323259:MHUN_RS03340
uniprot id: Q2FLK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

323259:MHUN RS01660
gene id: 323259:MHUN_RS01660
uniprot id: Q2FLF6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS01155
gene id: 323259:MHUN_RS01155
uniprot id: Q2FMJ2
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS12890
gene id: 323259:MHUN_RS12890
uniprot id: Q2FN75
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

323259:MHUN RS14905
gene id: 323259:MHUN_RS14905
uniprot id: Q2FRW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

323259:MHUN RS05935
gene id: 323259:MHUN_RS05935
uniprot id: Q2FPC8
names: Similarity
messages: Belongs to the UPF0179 family.

323259:MHUN RS02265
gene id: 323259:MHUN_RS02265
uniprot id: Q2FQG8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS13875
gene id: 323259:MHUN_RS13875
uniprot id: Q2FTF1
names: Similarity
messages: Belongs to the UPF0210 family.

323259:MHUN RS02885
gene id: 323259:MHUN_RS02885
uniprot id: Q2FNI2
names: Similarity
messages: Belongs to the disproportionating enzyme family.

323259:MHUN RS03280
gene id: 323259:MHUN_RS03280
uniprot id: Q2FN44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

323259:MHUN RS08640
gene id: 323259:MHUN_RS08640
uniprot id: Q2FRF1
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS03475
gene id: 323259:MHUN_RS03475
uniprot id: Q2FPX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

323259:MHUN RS16195
gene id: 323259:MHUN_RS16195
uniprot id: Q2FNG2
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

323259:MHUN RS17875
gene id: 323259:MHUN_RS17875
uniprot id: Q2FSC1
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

323259:MHUN RS00425
gene id: 323259:MHUN_RS00425
uniprot id: Q2FQN9
names: Similarity
messages: Belongs to the UPF0212 family.

323259:MHUN RS04920
gene id: 323259:MHUN_RS04920
uniprot id: Q2FN53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

323259:MHUN RS04780
gene id: 323259:MHUN_RS04780
uniprot id: Q2FQR5
names: Similarity
messages: Belongs to the UPF0146 family.

323259:MHUN RS09180
gene id: 323259:MHUN_RS09180
uniprot id: Q2FL44
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

323259:MHUN RS11495
gene id: 323259:MHUN_RS11495
uniprot id: Q2FSH7
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

323259:MHUN RS06695
gene id: 323259:MHUN_RS06695
uniprot id: Q2FP98
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.

323259:MHUN RS05410
gene id: 323259:MHUN_RS05410
uniprot id: Q2FQ50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

323259:MHUN RS13060
gene id: 323259:MHUN_RS13060
uniprot id: Q2FS34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

323259:MHUN RS05145
gene id: 323259:MHUN_RS05145
uniprot id: Q2FML6
names: Similarity
messages: Belongs to the MCM family.

323259:MHUN RS15240
gene id: 323259:MHUN_RS15240
uniprot id: Q2FTC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

323259:MHUN RS06095
gene id: 323259:MHUN_RS06095
uniprot id: Q2FPC5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

323259:MHUN RS04090
gene id: 323259:MHUN_RS04090
uniprot id: Q2FQ44
names: Similarity
messages: Belongs to the glutamate synthase family.

323259:MHUN RS00455
gene id: 323259:MHUN_RS00455
uniprot id: Q2FR16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

323259:MHUN RS02585
gene id: 323259:MHUN_RS02585
uniprot id: Q2FQ15
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

323259:MHUN RS14805
gene id: 323259:MHUN_RS14805
uniprot id: Q2FS61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

323259:MHUN RS12685
gene id: 323259:MHUN_RS12685
uniprot id: Q2FSF9
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).
messages: This protein undergoes a protein self splicing that involves a post-translational excision of the intervening region (intein) followed by peptide ligation.

323259:MHUN RS05825
gene id: 323259:MHUN_RS05825
uniprot id: Q2FPP8
names: Similarity
messages: Belongs to the GARS family.

323259:MHUN RS11005
gene id: 323259:MHUN_RS11005
uniprot id: Q2FTA7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS05965
gene id: 323259:MHUN_RS05965
uniprot id: Q2FLY2
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.

323259:MHUN RS00710
gene id: 323259:MHUN_RS00710
uniprot id: Q2FMZ3
names: Similarity
messages: Belongs to the UPF0280 family.

323259:MHUN RS01145
gene id: 323259:MHUN_RS01145
uniprot id: Q2FMJ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS13170
gene id: 323259:MHUN_RS13170
uniprot id: Q2FSE9
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

323259:MHUN RS08815
gene id: 323259:MHUN_RS08815
uniprot id: Q2FQI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

323259:MHUN RS05780
gene id: 323259:MHUN_RS05780
uniprot id: Q2FLB2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Binds two Mg(2+) per subunit.
messages: Forms a ternary complex with MCM helicase and DNA.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

323259:MHUN RS07800
gene id: 323259:MHUN_RS07800
uniprot id: Q2FNQ9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

323259:MHUN RS05830
gene id: 323259:MHUN_RS05830
uniprot id: Q2FPP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.

323259:MHUN RS13160
gene id: 323259:MHUN_RS13160
uniprot id: Q2FSF1
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

323259:MHUN RS07790
gene id: 323259:MHUN_RS07790
uniprot id: Q2FNR1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

323259:MHUN RS01085
gene id: 323259:MHUN_RS01085
uniprot id: Q2FPU3
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

323259:MHUN RS11865
gene id: 323259:MHUN_RS11865
uniprot id: Q2FT55
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

323259:MHUN RS05380
gene id: 323259:MHUN_RS05380
uniprot id: Q2FQ57
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

323259:MHUN RS12565
gene id: 323259:MHUN_RS12565
uniprot id: Q2FN87
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Requires K(+) for maximal activity.
messages: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.

323259:MHUN RS06320
gene id: 323259:MHUN_RS06320
uniprot id: Q2FM13
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

323259:MHUN RS12415
gene id: 323259:MHUN_RS12415
uniprot id: Q2FT11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

323259:MHUN RS10985
gene id: 323259:MHUN_RS10985
uniprot id: Q2FTA9
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS09255
gene id: 323259:MHUN_RS09255
uniprot id: Q2FQE3
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

323259:MHUN RS11605
gene id: 323259:MHUN_RS11605
uniprot id: Q2FSG4
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

323259:MHUN RS09190
gene id: 323259:MHUN_RS09190
uniprot id: Q2FL40
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

323259:MHUN RS01455
gene id: 323259:MHUN_RS01455
uniprot id: Q2FLM7
names: Similarity
messages: Belongs to the NifH/BchL/ChlL family.

323259:MHUN RS07765
gene id: 323259:MHUN_RS07765
uniprot id: Q2FNW9
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

323259:MHUN RS05425
gene id: 323259:MHUN_RS05425
uniprot id: Q2FQ56
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

323259:MHUN RS09685
gene id: 323259:MHUN_RS09685
uniprot id: Q2FQQ1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

323259:MHUN RS03360
gene id: 323259:MHUN_RS03360
uniprot id: Q2FLJ8
names: Function
messages: Part of a potassium transport system.

323259:MHUN RS14665
gene id: 323259:MHUN_RS14665
uniprot id: Q2FTJ3
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

323259:MHUN RS06700
gene id: 323259:MHUN_RS06700
uniprot id: Q2FP97
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

323259:MHUN RS08120
gene id: 323259:MHUN_RS08120
uniprot id: Q2FRJ1
names: Similarity
messages: In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.

323259:MHUN RS11430
gene id: 323259:MHUN_RS11430
uniprot id: Q2FSX0
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS03480
gene id: 323259:MHUN_RS03480
uniprot id: Q2FPX3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

323259:MHUN RS16225
gene id: 323259:MHUN_RS16225
uniprot id: Q2FUK4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

323259:MHUN RS02315
gene id: 323259:MHUN_RS02315
uniprot id: Q2FR23
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

323259:MHUN RS15800
gene id: 323259:MHUN_RS15800
uniprot id: Q2FS93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

323259:MHUN RS08355
gene id: 323259:MHUN_RS08355
uniprot id: Q2FQX4
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS13480
gene id: 323259:MHUN_RS13480
uniprot id: Q2FU32
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS00765
gene id: 323259:MHUN_RS00765
uniprot id: Q2FPH7
names: Similarity
messages: Belongs to the malic enzymes family.

323259:MHUN RS12555
gene id: 323259:MHUN_RS12555
uniprot id: Q2FT72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

323259:MHUN RS00990
gene id: 323259:MHUN_RS00990
uniprot id: Q2FMP0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS13535
gene id: 323259:MHUN_RS13535
uniprot id: Q2FTV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

323259:MHUN RS05490
gene id: 323259:MHUN_RS05490
uniprot id: Q2FR30
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

323259:MHUN RS09345
gene id: 323259:MHUN_RS09345
uniprot id: Q2FKX7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

323259:MHUN RS13575
gene id: 323259:MHUN_RS13575
uniprot id: Q2FSW1
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

323259:MHUN RS13350
gene id: 323259:MHUN_RS13350
uniprot id: Q2FTK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

323259:MHUN RS16500
gene id: 323259:MHUN_RS16500
uniprot id: Q2FNF2
names: Caution
names: Similarity
messages: Belongs to the acylphosphatase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

323259:MHUN RS00670
gene id: 323259:MHUN_RS00670
uniprot id: Q2FQP6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

323259:MHUN RS09330
gene id: 323259:MHUN_RS09330
uniprot id: Q2FKX5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

323259:MHUN RS15005
gene id: 323259:MHUN_RS15005
uniprot id: Q2FS38
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

323259:MHUN RS16775
gene id: 323259:MHUN_RS16775
uniprot id: Q2FRT8
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS11135
gene id: 323259:MHUN_RS11135
uniprot id: Q2FSN2
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

323259:MHUN RS10060
gene id: 323259:MHUN_RS10060
uniprot id: Q2FRH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

323259:MHUN RS01215
gene id: 323259:MHUN_RS01215
uniprot id: Q2FMW8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS15585
gene id: 323259:MHUN_RS15585
uniprot id: Q2FTF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
messages: Cell membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

323259:MHUN RS01100
gene id: 323259:MHUN_RS01100
uniprot id: Q2FN01
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS15740
gene id: 323259:MHUN_RS15740
uniprot id: Q2FTJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

323259:MHUN RS07825
gene id: 323259:MHUN_RS07825
uniprot id: Q2FNQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

323259:MHUN RS12520
gene id: 323259:MHUN_RS12520
uniprot id: Q2FT77
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

323259:MHUN RS02915
gene id: 323259:MHUN_RS02915
uniprot id: Q2FNH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

323259:MHUN RS11880
gene id: 323259:MHUN_RS11880
uniprot id: Q2FTS2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

323259:MHUN RS16995
gene id: 323259:MHUN_RS16995
uniprot id: Q2FQA2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

323259:MHUN RS11415
gene id: 323259:MHUN_RS11415
uniprot id: Q2FSX4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS06605
gene id: 323259:MHUN_RS06605
uniprot id: Q2FQI8
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS01020
gene id: 323259:MHUN_RS01020
uniprot id: Q2FPT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

323259:MHUN RS07530
gene id: 323259:MHUN_RS07530
uniprot id: Q2FLZ4
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

323259:MHUN RS11350
gene id: 323259:MHUN_RS11350
uniprot id: Q2FTY3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

323259:MHUN RS01765
gene id: 323259:MHUN_RS01765
uniprot id: Q2FN37
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS08400
gene id: 323259:MHUN_RS08400
uniprot id: Q2FRE1
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS12100
gene id: 323259:MHUN_RS12100
uniprot id: Q2FTG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

323259:MHUN RS12940
gene id: 323259:MHUN_RS12940
uniprot id: Q2FU14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

323259:MHUN RS09290
gene id: 323259:MHUN_RS09290
uniprot id: Q2FM58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

323259:MHUN RS12950
gene id: 323259:MHUN_RS12950
uniprot id: Q2FU12
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

323259:MHUN RS02725
gene id: 323259:MHUN_RS02725
uniprot id: Q2FMK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

323259:MHUN RS11765
gene id: 323259:MHUN_RS11765
uniprot id: Q2FTS5
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

323259:MHUN RS02345
gene id: 323259:MHUN_RS02345
uniprot id: Q2FUC6
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

323259:MHUN RS14945
gene id: 323259:MHUN_RS14945
uniprot id: Q2FTM7
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.

323259:MHUN RS11725
gene id: 323259:MHUN_RS11725
uniprot id: Q2FU89
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

323259:MHUN RS13460
gene id: 323259:MHUN_RS13460
uniprot id: Q2FU37
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS11600
gene id: 323259:MHUN_RS11600
uniprot id: Q2FSG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

323259:MHUN RS11165
gene id: 323259:MHUN_RS11165
uniprot id: Q2FSM6
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

323259:MHUN RS12070
gene id: 323259:MHUN_RS12070
uniprot id: Q2FSY9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

323259:MHUN RS15380
gene id: 323259:MHUN_RS15380
uniprot id: Q2FU41
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

323259:MHUN RS15105
gene id: 323259:MHUN_RS15105
uniprot id: Q2FTN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

323259:MHUN RS12325
gene id: 323259:MHUN_RS12325
uniprot id: Q2FSZ0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

323259:MHUN RS17215
gene id: 323259:MHUN_RS17215
uniprot id: Q2FLI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

323259:MHUN RS15080
gene id: 323259:MHUN_RS15080
uniprot id: Q2FTH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

323259:MHUN RS02905
gene id: 323259:MHUN_RS02905
uniprot id: Q2FNI3
names: Subcellular Location Annotation
messages: Cytoplasm

323259:MHUN RS05305
gene id: 323259:MHUN_RS05305
uniprot id: Q2FQM8
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

323259:MHUN RS06545
gene id: 323259:MHUN_RS06545
uniprot id: Q2FM37
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.

323259:MHUN RS07830
gene id: 323259:MHUN_RS07830
uniprot id: Q2FNQ3
names: Similarity
messages: Belongs to the HupF/HypC family.

323259:MHUN RS15555
gene id: 323259:MHUN_RS15555
uniprot id: Q2FSC3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the threonine synthase family. Cysteate synthase subfamily.
messages: Homotrimer.
messages: Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate.

323259:MHUN RS12145
gene id: 323259:MHUN_RS12145
uniprot id: Q2FNB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

323259:MHUN RS03530
gene id: 323259:MHUN_RS03530
uniprot id: Q2FR98
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

323259:MHUN RS12770
gene id: 323259:MHUN_RS12770
uniprot id: Q2FSR5
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

323259:MHUN RS13935
gene id: 323259:MHUN_RS13935
uniprot id: Q2FRY1
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

323259:MHUN RS11260
gene id: 323259:MHUN_RS11260
uniprot id: Q2FRN5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

323259:MHUN RS07645
gene id: 323259:MHUN_RS07645
uniprot id: Q2FLW1
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS01620
gene id: 323259:MHUN_RS01620
uniprot id: Q2FMT6
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS09370
gene id: 323259:MHUN_RS09370
uniprot id: Q2FKU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
messages: Monomer.

323259:MHUN RS17080
gene id: 323259:MHUN_RS17080
uniprot id: Q2FMT9
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

323259:MHUN RS09495
gene id: 323259:MHUN_RS09495
uniprot id: Q2FKS7
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS15360
gene id: 323259:MHUN_RS15360
uniprot id: Q2FU45
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

323259:MHUN RS04155
gene id: 323259:MHUN_RS04155
uniprot id: Q2FUB5
names: Similarity
messages: Belongs to the phosphoribulokinase family.

323259:MHUN RS11685
gene id: 323259:MHUN_RS11685
uniprot id: Q2FT36
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

323259:MHUN RS11295
gene id: 323259:MHUN_RS11295
uniprot id: Q2FRM8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

323259:MHUN RS05765
gene id: 323259:MHUN_RS05765
uniprot id: Q2FLB6
names: Similarity
messages: Belongs to the UPF0166 family.

323259:MHUN RS00970
gene id: 323259:MHUN_RS00970
uniprot id: Q2FMP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

323259:MHUN RS05405
gene id: 323259:MHUN_RS05405
uniprot id: Q2FQ51
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

323259:MHUN RS00465
gene id: 323259:MHUN_RS00465
uniprot id: Q2FR14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

323259:MHUN RS00605
gene id: 323259:MHUN_RS00605
uniprot id: Q2FLE0
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

323259:MHUN RS04340
gene id: 323259:MHUN_RS04340
uniprot id: Q2FUB0
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

323259:MHUN RS09235
gene id: 323259:MHUN_RS09235
uniprot id: Q2FQF0
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

323259:MHUN RS07775
gene id: 323259:MHUN_RS07775
uniprot id: Q2FNX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.

323259:MHUN RS12830
gene id: 323259:MHUN_RS12830
uniprot id: Q2FNA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

323259:MHUN RS11960
gene id: 323259:MHUN_RS11960
uniprot id: Q2FTR4
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

323259:MHUN RS12045
gene id: 323259:MHUN_RS12045
uniprot id: Q2FSY5
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

323259:MHUN RS06060
gene id: 323259:MHUN_RS06060
uniprot id: Q2FPC3
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

323259:MHUN RS16590
gene id: 323259:MHUN_RS16590
uniprot id: Q2FUK8
names: Similarity
messages: Belongs to the archease family.

323259:MHUN RS14790
gene id: 323259:MHUN_RS14790
uniprot id: Q2FS65
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

323259:MHUN RS11905
gene id: 323259:MHUN_RS11905
uniprot id: Q2FU57
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

323259:MHUN RS14950
gene id: 323259:MHUN_RS14950
uniprot id: Q2FTM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

323259:MHUN RS07780
gene id: 323259:MHUN_RS07780
uniprot id: Q2FNR3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

323259:MHUN RS01505
gene id: 323259:MHUN_RS01505
uniprot id: Q2FMY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

323259:MHUN RS02620
gene id: 323259:MHUN_RS02620
uniprot id: Q2FMR2
names: Similarity
messages: Belongs to the HypD family.

323259:MHUN RS13445
gene id: 323259:MHUN_RS13445
uniprot id: Q2FRW7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

323259:MHUN RS15795
gene id: 323259:MHUN_RS15795
uniprot id: Q2FS99
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

323259:MHUN RS16620
gene id: 323259:MHUN_RS16620
uniprot id: Q2FUL5
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

323259:MHUN RS07720
gene id: 323259:MHUN_RS07720
uniprot id: Q2FKR6
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS13735
gene id: 323259:MHUN_RS13735
uniprot id: Q2FS86
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

323259:MHUN RS13525
gene id: 323259:MHUN_RS13525
uniprot id: Q2FTW0
names: Similarity
messages: Belongs to the NAPRTase family.

323259:MHUN RS11695
gene id: 323259:MHUN_RS11695
uniprot id: Q2FU94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

323259:MHUN RS04565
gene id: 323259:MHUN_RS04565
uniprot id: Q2FR88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

323259:MHUN RS10835
gene id: 323259:MHUN_RS10835
uniprot id: Q2FM97
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS11115
gene id: 323259:MHUN_RS11115
uniprot id: Q2FSE0
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

323259:MHUN RS12160
gene id: 323259:MHUN_RS12160
uniprot id: Q2FNB2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

323259:MHUN RS06355
gene id: 323259:MHUN_RS06355
uniprot id: Q2FNJ0
names: Similarity
messages: Belongs to the acylphosphatase family.

323259:MHUN RS15165
gene id: 323259:MHUN_RS15165
uniprot id: Q2FT96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

323259:MHUN RS06175
gene id: 323259:MHUN_RS06175
uniprot id: Q2FNK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

323259:MHUN RS10795
gene id: 323259:MHUN_RS10795
uniprot id: Q2FMB7
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.

323259:MHUN RS15725
gene id: 323259:MHUN_RS15725
uniprot id: Q2FTJ8
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS11680
gene id: 323259:MHUN_RS11680
uniprot id: Q2FT39
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

323259:MHUN RS14660
gene id: 323259:MHUN_RS14660
uniprot id: Q2FS48
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

323259:MHUN RS01495
gene id: 323259:MHUN_RS01495
uniprot id: Q2FQR0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS13305
gene id: 323259:MHUN_RS13305
uniprot id: Q2FTL6
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

323259:MHUN RS00995
gene id: 323259:MHUN_RS00995
uniprot id: Q2FMN9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS02295
gene id: 323259:MHUN_RS02295
uniprot id: Q2FR27
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

323259:MHUN RS10045
gene id: 323259:MHUN_RS10045
uniprot id: Q2FM63
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

323259:MHUN RS09020
gene id: 323259:MHUN_RS09020
uniprot id: Q2FLL1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

323259:MHUN RS13515
gene id: 323259:MHUN_RS13515
uniprot id: Q2FTW3
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS06380
gene id: 323259:MHUN_RS06380
uniprot id: Q2FP80
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

323259:MHUN RS19240
gene id: 323259:MHUN_RS19240
uniprot id: Q2FT07
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

323259:MHUN RS15745
gene id: 323259:MHUN_RS15745
uniprot id: Q2FTJ7
names: Similarity
messages: Belongs to the PDCD5 family.

323259:MHUN RS02920
gene id: 323259:MHUN_RS02920
uniprot id: Q2FNH7
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS09175
gene id: 323259:MHUN_RS09175
uniprot id: Q2FL45
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

323259:MHUN RS06580
gene id: 323259:MHUN_RS06580
uniprot id: Q2FP90
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

323259:MHUN RS14770
gene id: 323259:MHUN_RS14770
uniprot id: Q2FS70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

323259:MHUN RS07990
gene id: 323259:MHUN_RS07990
uniprot id: Q2FP41
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS01180
gene id: 323259:MHUN_RS01180
uniprot id: Q2FPY1
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

323259:MHUN RS06200
gene id: 323259:MHUN_RS06200
uniprot id: Q2FP52
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

323259:MHUN RS00685
gene id: 323259:MHUN_RS00685
uniprot id: Q2FMS7
names: Similarity
messages: Belongs to the peptidase M3 family.

323259:MHUN RS08610
gene id: 323259:MHUN_RS08610
uniprot id: Q2FQZ1
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

323259:MHUN RS00485
gene id: 323259:MHUN_RS00485
uniprot id: Q2FLD1
names: Similarity
messages: Belongs to the class-I fumarase family.

323259:MHUN RS10400
gene id: 323259:MHUN_RS10400
uniprot id: Q2FMG6
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS11460
gene id: 323259:MHUN_RS11460
uniprot id: Q2FSH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

323259:MHUN RS11265
gene id: 323259:MHUN_RS11265
uniprot id: Q2FRN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

323259:MHUN RS16105
gene id: 323259:MHUN_RS16105
uniprot id: Q2FTR1
names: Similarity
messages: Belongs to the ABC transporter superfamily.

323259:MHUN RS05080
gene id: 323259:MHUN_RS05080
uniprot id: Q2FPE0
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

323259:MHUN RS06530
gene id: 323259:MHUN_RS06530
uniprot id: Q2FM35
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

323259:MHUN RS04110
gene id: 323259:MHUN_RS04110
uniprot id: Q2FQ40
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

323259:MHUN RS04520
gene id: 323259:MHUN_RS04520
uniprot id: Q2FUC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

323259:MHUN RS03975
gene id: 323259:MHUN_RS03975
uniprot id: Q2FPB7
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS04045
gene id: 323259:MHUN_RS04045
uniprot id: Q2FQT1
names: Cofactor
names: Similarity
messages: Belongs to the desulfoferrodoxin family.
messages: Binds 1 Fe(2+) ion per subunit. The iron ion 2 is coordinated via four histidines and one cysteine residue.
messages: Binds 1 Fe(3+) ion per subunit. The iron ion 1 is coordinated via 4 cysteine residues.

323259:MHUN RS05440
gene id: 323259:MHUN_RS05440
uniprot id: Q2FUD8
names: Similarity
messages: Belongs to the UPF0107 family.

323259:MHUN RS00675
gene id: 323259:MHUN_RS00675
uniprot id: Q2FQP2
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

323259:MHUN RS10945
gene id: 323259:MHUN_RS10945
uniprot id: Q2FLM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

323259:MHUN RS01065
gene id: 323259:MHUN_RS01065
uniprot id: Q2FL97
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS13280
gene id: 323259:MHUN_RS13280
uniprot id: Q2FTM2
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

323259:MHUN RS14440
gene id: 323259:MHUN_RS14440
uniprot id: Q2FU24
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

323259:MHUN RS17855
gene id: 323259:MHUN_RS17855
uniprot id: Q2FU40
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

323259:MHUN RS06615
gene id: 323259:MHUN_RS06615
uniprot id: Q2FPM5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).

323259:MHUN RS11445
gene id: 323259:MHUN_RS11445
uniprot id: Q2FSW8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

323259:MHUN RS10290
gene id: 323259:MHUN_RS10290
uniprot id: Q2FRC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

323259:MHUN RS07665
gene id: 323259:MHUN_RS07665
uniprot id: Q2FP88
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

323259:MHUN RS16770
gene id: 323259:MHUN_RS16770
uniprot id: Q2FRT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

323259:MHUN RS05460
gene id: 323259:MHUN_RS05460
uniprot id: Q2FUD5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

323259:MHUN RS11035
gene id: 323259:MHUN_RS11035
uniprot id: Q2FN94
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

323259:MHUN RS15825
gene id: 323259:MHUN_RS15825
uniprot id: Q2FSA5
names: Similarity
messages: Belongs to the PurH family.

323259:MHUN RS08460
gene id: 323259:MHUN_RS08460
uniprot id: Q2FRF7
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

323259:MHUN RS12200
gene id: 323259:MHUN_RS12200
uniprot id: Q2FRY8
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

323259:MHUN RS05290
gene id: 323259:MHUN_RS05290
uniprot id: Q2FQM2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

323259:MHUN RS15590
gene id: 323259:MHUN_RS15590
uniprot id: Q2FTF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

323259:MHUN RS03140
gene id: 323259:MHUN_RS03140
uniprot id: Q2FLP2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

323259:MHUN RS08910
gene id: 323259:MHUN_RS08910
uniprot id: Q2FR06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

323259:MHUN RS00480
gene id: 323259:MHUN_RS00480
uniprot id: Q2FLD2
names: Similarity
messages: Belongs to the class-I fumarase family.

323259:MHUN RS00515
gene id: 323259:MHUN_RS00515
uniprot id: Q2FPT7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

323259:MHUN RS06265
gene id: 323259:MHUN_RS06265
uniprot id: Q2FM22
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

323259:MHUN RS14300
gene id: 323259:MHUN_RS14300
uniprot id: Q2FT43
names: Similarity
messages: Belongs to the UPF0758 family.

323259:MHUN RS08325
gene id: 323259:MHUN_RS08325
uniprot id: Q2FRI1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

323259:MHUN RS00870
gene id: 323259:MHUN_RS00870
uniprot id: Q2FPH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Probably functions as a manganese efflux pump.

323259:MHUN RS04015
gene id: 323259:MHUN_RS04015
uniprot id: Q2FPB3
names: Similarity
messages: Belongs to the HepT RNase toxin family.

323259:MHUN RS11665
gene id: 323259:MHUN_RS11665
uniprot id: Q2FT32
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

323259:MHUN RS14980
gene id: 323259:MHUN_RS14980
uniprot id: Q2FTM6
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

323259:MHUN RS08320
gene id: 323259:MHUN_RS08320
uniprot id: Q2FRI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

323259:MHUN RS15790
gene id: 323259:MHUN_RS15790
uniprot id: Q2FSA0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

323259:MHUN RS05840
gene id: 323259:MHUN_RS05840
uniprot id: Q2FPP5
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS09025
gene id: 323259:MHUN_RS09025
uniprot id: Q2FLL0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

323259:MHUN RS11770
gene id: 323259:MHUN_RS11770
uniprot id: Q2FTS3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: S-layer

323259:MHUN RS12870
gene id: 323259:MHUN_RS12870
uniprot id: Q2FN79
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

323259:MHUN RS17435
gene id: 323259:MHUN_RS17435
uniprot id: Q2FP12
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

323259:MHUN RS12290
gene id: 323259:MHUN_RS12290
uniprot id: Q2FSZ4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

323259:MHUN RS10330
gene id: 323259:MHUN_RS10330
uniprot id: Q2FRL8
names: Similarity
messages: Belongs to the FwdC/FmdC family.

323259:MHUN RS04150
gene id: 323259:MHUN_RS04150
uniprot id: Q2FUB7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the NifH/BchL/ChlL family.
messages: Binds 1 [4Fe-4S] cluster per dimer.
messages: Homodimer.
messages: The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
messages: The reversible ADP-ribosylation of Arg-98 inactivates the nitrogenase reductase and regulates nitrogenase activity.

323259:MHUN RS04530
gene id: 323259:MHUN_RS04530
uniprot id: Q2FR94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

323259:MHUN RS12270
gene id: 323259:MHUN_RS12270
uniprot id: Q2FSL3
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

323259:MHUN RS01320
gene id: 323259:MHUN_RS01320
uniprot id: Q2FMK4
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

323259:MHUN RS13730
gene id: 323259:MHUN_RS13730
uniprot id: Q2FS88
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

323259:MHUN RS04405
gene id: 323259:MHUN_RS04405
uniprot id: Q2FR68
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

323259:MHUN RS04080
gene id: 323259:MHUN_RS04080
uniprot id: Q2FQ47
names: Similarity
messages: Belongs to the glutamine synthetase family.

323259:MHUN RS16570
gene id: 323259:MHUN_RS16570
uniprot id: Q2FUL1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

323259:MHUN RS11910
gene id: 323259:MHUN_RS11910
uniprot id: Q2FU56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

323259:MHUN RS08175
gene id: 323259:MHUN_RS08175
uniprot id: Q2FL22
names: Similarity
messages: Belongs to the UPF0215 family.

323259:MHUN RS03180
gene id: 323259:MHUN_RS03180
uniprot id: Q2FPJ4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

323259:MHUN RS09040
gene id: 323259:MHUN_RS09040
uniprot id: Q2FKW3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

323259:MHUN RS12495
gene id: 323259:MHUN_RS12495
uniprot id: Q2FT01
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

323259:MHUN RS11670
gene id: 323259:MHUN_RS11670
uniprot id: Q2FT31
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

323259:MHUN RS15065
gene id: 323259:MHUN_RS15065
uniprot id: Q2FTH4
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

323259:MHUN RS11630
gene id: 323259:MHUN_RS11630
uniprot id: Q2FSG5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

323259:MHUN RS17030
gene id: 323259:MHUN_RS17030
uniprot id: Q2FLV5
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

323259:MHUN RS00615
gene id: 323259:MHUN_RS00615
uniprot id: Q2FLD8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

323259:MHUN RS13720
gene id: 323259:MHUN_RS13720
uniprot id: Q2FS90
names: Similarity
messages: Belongs to the thymidylate kinase family.

323259:MHUN RS01095
gene id: 323259:MHUN_RS01095
uniprot id: Q2FPU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

323259:MHUN RS12055
gene id: 323259:MHUN_RS12055
uniprot id: Q2FSY3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

323259:MHUN RS05860
gene id: 323259:MHUN_RS05860
uniprot id: Q2FUA6
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

323259:MHUN RS15945
gene id: 323259:MHUN_RS15945
uniprot id: Q2FT48
names: Similarity
messages: Belongs to the ZPR1 family.

323259:MHUN RS06590
gene id: 323259:MHUN_RS06590
uniprot id: Q2FQJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

323259:MHUN RS09240
gene id: 323259:MHUN_RS09240
uniprot id: Q2FQE9
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

323259:MHUN RS06995
gene id: 323259:MHUN_RS06995
uniprot id: Q2FNW2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS12030
gene id: 323259:MHUN_RS12030
uniprot id: Q2FRP6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS07655
gene id: 323259:MHUN_RS07655
uniprot id: Q2FLW5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS13490
gene id: 323259:MHUN_RS13490
uniprot id: Q2FU34
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS06050
gene id: 323259:MHUN_RS06050
uniprot id: Q2FP83
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

323259:MHUN RS12285
gene id: 323259:MHUN_RS12285
uniprot id: Q2FSZ6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

323259:MHUN RS03265
gene id: 323259:MHUN_RS03265
uniprot id: Q2FN47
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

323259:MHUN RS12745
gene id: 323259:MHUN_RS12745
uniprot id: Q2FRU5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.

323259:MHUN RS06170
gene id: 323259:MHUN_RS06170
uniprot id: Q2FNK6
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

323259:MHUN RS08155
gene id: 323259:MHUN_RS08155
uniprot id: Q2FRF0
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

323259:MHUN RS06205
gene id: 323259:MHUN_RS06205
uniprot id: Q2FP51
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

323259:MHUN RS03465
gene id: 323259:MHUN_RS03465
uniprot id: Q2FPX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

323259:MHUN RS08430
gene id: 323259:MHUN_RS08430
uniprot id: Q2FRG5
names: Similarity
messages: Belongs to the band 7/mec-2 family.

323259:MHUN RS09585
gene id: 323259:MHUN_RS09585
uniprot id: Q2FKZ2
names: Similarity
messages: Belongs to the HdrB family.

323259:MHUN RS00410
gene id: 323259:MHUN_RS00410
uniprot id: Q2FLN1
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS10640
gene id: 323259:MHUN_RS10640
uniprot id: Q2FPA5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

323259:MHUN RS04665
gene id: 323259:MHUN_RS04665
uniprot id: Q2FPZ8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

323259:MHUN RS09350
gene id: 323259:MHUN_RS09350
uniprot id: Q2FKX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

323259:MHUN RS05770
gene id: 323259:MHUN_RS05770
uniprot id: Q2FLB5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

323259:MHUN RS15225
gene id: 323259:MHUN_RS15225
uniprot id: Q2FTC7
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

323259:MHUN RS05520
gene id: 323259:MHUN_RS05520
uniprot id: Q2FPN6
names: Similarity
messages: Belongs to the GroES chaperonin family.

323259:MHUN RS14915
gene id: 323259:MHUN_RS14915
uniprot id: Q2FRW0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

323259:MHUN RS02325
gene id: 323259:MHUN_RS02325
uniprot id: Q2FR21
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

323259:MHUN RS15025
gene id: 323259:MHUN_RS15025
uniprot id: Q2FS40
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

323259:MHUN RS13345
gene id: 323259:MHUN_RS13345
uniprot id: Q2FTK7
names: Similarity
messages: Belongs to the HMBS family.

323259:MHUN RS14680
gene id: 323259:MHUN_RS14680
uniprot id: Q2FTI9
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS12670
gene id: 323259:MHUN_RS12670
uniprot id: Q2FSF4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the peroxidase family. Peroxidase/catalase subfamily.
messages: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.
messages: Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
messages: Homodimer or homotetramer.

323259:MHUN RS04125
gene id: 323259:MHUN_RS04125
uniprot id: Q2FQ45
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

323259:MHUN RS02220
gene id: 323259:MHUN_RS02220
uniprot id: Q2FQH3
names: Similarity
messages: Belongs to the HepT RNase toxin family.

323259:MHUN RS13075
gene id: 323259:MHUN_RS13075
uniprot id: Q2FS27
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

323259:MHUN RS15920
gene id: 323259:MHUN_RS15920
uniprot id: Q2FT65
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

323259:MHUN RS11455
gene id: 323259:MHUN_RS11455
uniprot id: Q2FSX1
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

323259:MHUN RS00120
gene id: 323259:MHUN_RS00120
uniprot id: Q2FLH3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

323259:MHUN RS06020
gene id: 323259:MHUN_RS06020
uniprot id: Q2FP84
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS15000
gene id: 323259:MHUN_RS15000
uniprot id: Q2FS42
names: Similarity
messages: Belongs to the HAM1 NTPase family.

323259:MHUN RS09285
gene id: 323259:MHUN_RS09285
uniprot id: Q2FM59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

323259:MHUN RS08375
gene id: 323259:MHUN_RS08375
uniprot id: Q2FQX1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

323259:MHUN RS12805
gene id: 323259:MHUN_RS12805
uniprot id: Q2FNA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

323259:MHUN RS05760
gene id: 323259:MHUN_RS05760
uniprot id: Q2FLB7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

323259:MHUN RS06070
gene id: 323259:MHUN_RS06070
uniprot id: Q2FPC1
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

323259:MHUN RS14970
gene id: 323259:MHUN_RS14970
uniprot id: Q2FTM9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

323259:MHUN RS04315
gene id: 323259:MHUN_RS04315
uniprot id: Q2FMU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

323259:MHUN RS03435
gene id: 323259:MHUN_RS03435
uniprot id: Q2FQ35
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

323259:MHUN RS13095
gene id: 323259:MHUN_RS13095
uniprot id: Q2FS30
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

323259:MHUN RS09185
gene id: 323259:MHUN_RS09185
uniprot id: Q2FL43
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

323259:MHUN RS09095
gene id: 323259:MHUN_RS09095
uniprot id: Q2FL39
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS09435
gene id: 323259:MHUN_RS09435
uniprot id: Q2FKY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

323259:MHUN RS15755
gene id: 323259:MHUN_RS15755
uniprot id: Q2FS98
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

323259:MHUN RS11650
gene id: 323259:MHUN_RS11650
uniprot id: Q2FT37
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

323259:MHUN RS07770
gene id: 323259:MHUN_RS07770
uniprot id: Q2FNX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

323259:MHUN RS14815
gene id: 323259:MHUN_RS14815
uniprot id: Q2FS62
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

323259:MHUN RS11635
gene id: 323259:MHUN_RS11635
uniprot id: Q2FSG2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

323259:MHUN RS09245
gene id: 323259:MHUN_RS09245
uniprot id: Q2FQE7
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

323259:MHUN RS09580
gene id: 323259:MHUN_RS09580
uniprot id: Q2FKZ3
names: Similarity
messages: Belongs to the HdrC family.

323259:MHUN RS12245
gene id: 323259:MHUN_RS12245
uniprot id: Q2FSK9
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

323259:MHUN RS00345
gene id: 323259:MHUN_RS00345
uniprot id: Q2FMI4
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

323259:MHUN RS07995
gene id: 323259:MHUN_RS07995
uniprot id: Q2FP39
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS00165
gene id: 323259:MHUN_RS00165
uniprot id: Q2FQF3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS13340
gene id: 323259:MHUN_RS13340
uniprot id: Q2FTK8
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

323259:MHUN RS05325
gene id: 323259:MHUN_RS05325
uniprot id: Q2FQL9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

323259:MHUN RS01255
gene id: 323259:MHUN_RS01255
uniprot id: Q2FUE2
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS05880
gene id: 323259:MHUN_RS05880
uniprot id: Q2FUA4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

323259:MHUN RS04740
gene id: 323259:MHUN_RS04740
uniprot id: Q2FQ90
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

323259:MHUN RS10080
gene id: 323259:MHUN_RS10080
uniprot id: Q2FRH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

323259:MHUN RS06935
gene id: 323259:MHUN_RS06935
uniprot id: Q2FNY3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS11365
gene id: 323259:MHUN_RS11365
uniprot id: Q2FU69
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

323259:MHUN RS11710
gene id: 323259:MHUN_RS11710
uniprot id: Q2FU91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

323259:MHUN RS04505
gene id: 323259:MHUN_RS04505
uniprot id: Q2FUD1
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

323259:MHUN RS09395
gene id: 323259:MHUN_RS09395
uniprot id: Q2FKT8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

323259:MHUN RS11855
gene id: 323259:MHUN_RS11855
uniprot id: Q2FT57
names: Cofactor
names: Function
names: Similarity
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity).
messages: Binds 1 potassium ion per subunit.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.

323259:MHUN RS14285
gene id: 323259:MHUN_RS14285
uniprot id: Q2FT41
names: Cofactor
messages: Binds 2 irons ions per subunit via 4 cysteine residues per iron.

323259:MHUN RS05095
gene id: 323259:MHUN_RS05095
uniprot id: Q2FQV7
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

323259:MHUN RS04350
gene id: 323259:MHUN_RS04350
uniprot id: Q2FUA9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

323259:MHUN RS09960
gene id: 323259:MHUN_RS09960
uniprot id: Q2FLU0
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

323259:MHUN RS05775
gene id: 323259:MHUN_RS05775
uniprot id: Q2FLB4
names: Similarity
messages: Belongs to the UPF0235 family.

323259:MHUN RS16780
gene id: 323259:MHUN_RS16780
uniprot id: Q2FRT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).

323259:MHUN RS03290
gene id: 323259:MHUN_RS03290
uniprot id: Q2FN43
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

323259:MHUN RS14435
gene id: 323259:MHUN_RS14435
uniprot id: Q2FU26
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

323259:MHUN RS04990
gene id: 323259:MHUN_RS04990
uniprot id: Q2FPV2
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

323259:MHUN RS00600
gene id: 323259:MHUN_RS00600
uniprot id: Q2FMS8
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

323259:MHUN RS11925
gene id: 323259:MHUN_RS11925
uniprot id: Q2FU63
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

323259:MHUN RS06180
gene id: 323259:MHUN_RS06180
uniprot id: Q2FNK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane

323259:MHUN RS13770
gene id: 323259:MHUN_RS13770
uniprot id: Q2FST8
names: Similarity
messages: Belongs to the methylamine corrinoid protein family.

323259:MHUN RS04820
gene id: 323259:MHUN_RS04820
uniprot id: Q2FN14
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

323259:MHUN RS07005
gene id: 323259:MHUN_RS07005
uniprot id: Q2FNW0
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

323259:MHUN RS16615
gene id: 323259:MHUN_RS16615
uniprot id: Q2FUL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

323259:MHUN RS04035
gene id: 323259:MHUN_RS04035
uniprot id: Q2FQT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

323259:MHUN RS00205
gene id: 323259:MHUN_RS00205
uniprot id: Q2FQD8
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

323259:MHUN RS07480
gene id: 323259:MHUN_RS07480
uniprot id: Q2FLX1
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

323259:MHUN RS04610
gene id: 323259:MHUN_RS04610
uniprot id: Q2FQC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAK/KUP transporter (TC 2.A.72) family.
messages: Cell membrane
messages: Transport of potassium into the cell. Likely operates as a K(+):H(+) symporter.

323259:MHUN RS00280
gene id: 323259:MHUN_RS00280
uniprot id: Q2FPK1
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Part of the RNA polymerase complex.

323259:MHUN RS04995
gene id: 323259:MHUN_RS04995
uniprot id: Q2FPV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

323259:MHUN RS07055
gene id: 323259:MHUN_RS07055
uniprot id: Q2FNP3
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS11595
gene id: 323259:MHUN_RS11595
uniprot id: Q2FSG8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

323259:MHUN RS03855
gene id: 323259:MHUN_RS03855
uniprot id: Q2FL78
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

323259:MHUN RS02975
gene id: 323259:MHUN_RS02975
uniprot id: Q2FLE8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

323259:MHUN RS03850
gene id: 323259:MHUN_RS03850
uniprot id: Q2FL79
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

323259:MHUN RS11125
gene id: 323259:MHUN_RS11125
uniprot id: Q2FSD8
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

323259:MHUN RS04200
gene id: 323259:MHUN_RS04200
uniprot id: Q2FPG1
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

323259:MHUN RS13455
gene id: 323259:MHUN_RS13455
uniprot id: Q2FU38
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS19690
gene id: 323259:MHUN_RS19690
uniprot id: Q2FLC7
names: Similarity
messages: Belongs to the peptidase C1 family.

323259:MHUN RS03255
gene id: 323259:MHUN_RS03255
uniprot id: Q2FN09
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic CoaD family.
messages: Cytoplasm
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

323259:MHUN RS12705
gene id: 323259:MHUN_RS12705
uniprot id: Q2FRV1
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

323259:MHUN RS17160
gene id: 323259:MHUN_RS17160
uniprot id: Q2FLJ4
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS15780
gene id: 323259:MHUN_RS15780
uniprot id: Q2FS94
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

323259:MHUN RS05910
gene id: 323259:MHUN_RS05910
uniprot id: Q2FPD3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

323259:MHUN RS11645
gene id: 323259:MHUN_RS11645
uniprot id: Q2FT38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

323259:MHUN RS16895
gene id: 323259:MHUN_RS16895
uniprot id: Q2FTZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

323259:MHUN RS04615
gene id: 323259:MHUN_RS04615
uniprot id: Q2FQB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

323259:MHUN RS01340
gene id: 323259:MHUN_RS01340
uniprot id: Q2FLR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

323259:MHUN RS12155
gene id: 323259:MHUN_RS12155
uniprot id: Q2FNB3
names: Similarity
messages: Belongs to the AAA ATPase family.

323259:MHUN RS12140
gene id: 323259:MHUN_RS12140
uniprot id: Q2FNB6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

323259:MHUN RS03250
gene id: 323259:MHUN_RS03250
uniprot id: Q2FN10
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

323259:MHUN RS05350
gene id: 323259:MHUN_RS05350
uniprot id: Q2FPH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

323259:MHUN RS10320
gene id: 323259:MHUN_RS10320
uniprot id: Q2FRM0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FwdB family.
messages: Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
messages: This enzyme is composed of six subunits FwdA, FwdC, FwdD, FwdE, FwdF and FwdG.

323259:MHUN RS10815
gene id: 323259:MHUN_RS10815
uniprot id: Q2FM91
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS00105
gene id: 323259:MHUN_RS00105
uniprot id: Q2FR55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

323259:MHUN RS05295
gene id: 323259:MHUN_RS05295
uniprot id: Q2FQM1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

323259:MHUN RS16575
gene id: 323259:MHUN_RS16575
uniprot id: Q2FUL0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

323259:MHUN RS16795
gene id: 323259:MHUN_RS16795
uniprot id: Q2FRU0
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

323259:MHUN RS14960
gene id: 323259:MHUN_RS14960
uniprot id: Q2FTN2
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.

323259:MHUN RS15075
gene id: 323259:MHUN_RS15075
uniprot id: Q2FTH8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

323259:MHUN RS00085
gene id: 323259:MHUN_RS00085
uniprot id: Q2FR54
names: Similarity
messages: Belongs to the peptidase S8 family.

323259:MHUN RS13585
gene id: 323259:MHUN_RS13585
uniprot id: Q2FSV9
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

323259:MHUN RS15770
gene id: 323259:MHUN_RS15770
uniprot id: Q2FS96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

323259:MHUN RS16870
gene id: 323259:MHUN_RS16870
uniprot id: Q2FU05
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

323259:MHUN RS07705
gene id: 323259:MHUN_RS07705
uniprot id: Q2FKR9
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS04230
gene id: 323259:MHUN_RS04230
uniprot id: Q2FLI6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

323259:MHUN RS17935
gene id: 323259:MHUN_RS17935
uniprot id: Q2FUI5
names: Similarity
messages: Belongs to the acylphosphatase family.

323259:MHUN RS11275
gene id: 323259:MHUN_RS11275
uniprot id: Q2FRN2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

323259:MHUN RS11620
gene id: 323259:MHUN_RS11620
uniprot id: Q2FSG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

323259:MHUN RS08855
gene id: 323259:MHUN_RS08855
uniprot id: Q2FR12
names: Similarity
messages: Belongs to the acylphosphatase family.

323259:MHUN RS01525
gene id: 323259:MHUN_RS01525
uniprot id: Q2FMX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

323259:MHUN RS14985
gene id: 323259:MHUN_RS14985
uniprot id: Q2FS46
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

323259:MHUN RS15090
gene id: 323259:MHUN_RS15090
uniprot id: Q2FTP2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

323259:MHUN RS04765
gene id: 323259:MHUN_RS04765
uniprot id: Q2FQR8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

323259:MHUN RS03225
gene id: 323259:MHUN_RS03225
uniprot id: Q2FPI8
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

323259:MHUN RS16875
gene id: 323259:MHUN_RS16875
uniprot id: Q2FU04
names: Caution
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

323259:MHUN RS05390
gene id: 323259:MHUN_RS05390
uniprot id: Q2FQ54
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

323259:MHUN RS01680
gene id: 323259:MHUN_RS01680
uniprot id: Q2FMU2
names: Similarity
messages: Belongs to the leucine-binding protein family.

323259:MHUN RS15995
gene id: 323259:MHUN_RS15995
uniprot id: Q2FSJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

323259:MHUN RS08510
gene id: 323259:MHUN_RS08510
uniprot id: Q2FQ74
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

323259:MHUN RS15320
gene id: 323259:MHUN_RS15320
uniprot id: Q2FS78
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS04840
gene id: 323259:MHUN_RS04840
uniprot id: Q2FQW1
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

323259:MHUN RS15760
gene id: 323259:MHUN_RS15760
uniprot id: Q2FS97
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

323259:MHUN RS16035
gene id: 323259:MHUN_RS16035
uniprot id: Q2FRS6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

323259:MHUN RS06090
gene id: 323259:MHUN_RS06090
uniprot id: Q2FPC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

323259:MHUN RS04220
gene id: 323259:MHUN_RS04220
uniprot id: Q2FLI8
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

323259:MHUN RS10975
gene id: 323259:MHUN_RS10975
uniprot id: Q2FTB1
names: Similarity
messages: Belongs to the UDPGP type 2 family.

323259:MHUN RS07725
gene id: 323259:MHUN_RS07725
uniprot id: Q2FNX9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).

323259:MHUN RS00450
gene id: 323259:MHUN_RS00450
uniprot id: Q2FR17
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

323259:MHUN RS00690
gene id: 323259:MHUN_RS00690
uniprot id: Q2FMS4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Dps family.
messages: Homododecamer. The 12 identical subunits form a hollow sphere into which the mineral iron core of up to 300 Fe(3+) can be deposited.
messages: Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction.
messages: nucleoid

323259:MHUN RS11660
gene id: 323259:MHUN_RS11660
uniprot id: Q2FT33
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

323259:MHUN RS15110
gene id: 323259:MHUN_RS15110
uniprot id: Q2FTN8
names: Similarity
messages: Belongs to the MEMO1 family.

323259:MHUN RS15325
gene id: 323259:MHUN_RS15325
uniprot id: Q2FS77
names: Subcellular Location Annotation
messages: Membrane

323259:MHUN RS04800
gene id: 323259:MHUN_RS04800
uniprot id: Q2FN15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

323259:MHUN RS04140
gene id: 323259:MHUN_RS04140
uniprot id: Q2FUB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

323259:MHUN RS11140
gene id: 323259:MHUN_RS11140
uniprot id: Q2FSN1
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

323259:MHUN RS08340
gene id: 323259:MHUN_RS08340
uniprot id: Q2FQX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

323259:MHUN RS16190
gene id: 323259:MHUN_RS16190
uniprot id: Q2FNG3
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.

323259:MHUN RS01140
gene id: 323259:MHUN_RS01140
uniprot id: Q2FMJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

323259:MHUN RS05900
gene id: 323259:MHUN_RS05900
uniprot id: Q2FPD5
names: Similarity
messages: Belongs to the eIF-2-alpha family.

323259:MHUN RS02720
gene id: 323259:MHUN_RS02720
uniprot id: Q2FMK2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

323259:MHUN RS11335
gene id: 323259:MHUN_RS11335
uniprot id: Q2FTY2
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

323259:MHUN RS05435
gene id: 323259:MHUN_RS05435
uniprot id: Q2FUD9
names: Similarity
messages: Belongs to the AAA ATPase family.

323259:MHUN RS06665
gene id: 323259:MHUN_RS06665
uniprot id: Q2FNU7
names: Similarity
messages: Belongs to the UPF0305 family.