315358:SERIO RS01045
gene id: 315358:SERIO_RS01045
uniprot id: A0A0H3XJ32
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

315358:SERIO RS01385
gene id: 315358:SERIO_RS01385
uniprot id: A0A0H3XHP1
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

315358:SERIO RS03575
gene id: 315358:SERIO_RS03575
uniprot id: A0A0H3XK82
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

315358:SERIO RS05600
gene id: 315358:SERIO_RS05600
uniprot id: A0A0H3XNA0
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

315358:SERIO RS04830
gene id: 315358:SERIO_RS04830
uniprot id: A0A0H3XLT0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

315358:SERIO RS01290
gene id: 315358:SERIO_RS01290
uniprot id: A0A0H3XH12
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

315358:SERIO RS03785
gene id: 315358:SERIO_RS03785
uniprot id: A0A0H3XHS6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

315358:SERIO RS02215
gene id: 315358:SERIO_RS02215
uniprot id: A0A0H3XHY2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

315358:SERIO RS06005
gene id: 315358:SERIO_RS06005
uniprot id: A0A0H3XLD9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

315358:SERIO RS06200
gene id: 315358:SERIO_RS06200
uniprot id: A0A0H3XMD8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

315358:SERIO RS05145
gene id: 315358:SERIO_RS05145
uniprot id: A0A0H3XJ38
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

315358:SERIO RS05905
gene id: 315358:SERIO_RS05905
uniprot id: A0A0H3XLC4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

315358:SERIO RS02185
gene id: 315358:SERIO_RS02185
uniprot id: A0A0H3XHA4
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS04260
gene id: 315358:SERIO_RS04260
uniprot id: A0A0H3XHX8
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

315358:SERIO RS01470
gene id: 315358:SERIO_RS01470
uniprot id: A0A0H3XM08
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

315358:SERIO RS01840
gene id: 315358:SERIO_RS01840
uniprot id: A0A0H3XM62
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS05230
gene id: 315358:SERIO_RS05230
uniprot id: A0A0H3XN59
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

315358:SERIO RS04010
gene id: 315358:SERIO_RS04010
uniprot id: A0A0H3XKE2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

315358:SERIO RS03195
gene id: 315358:SERIO_RS03195
uniprot id: A0A0H3XML9
names: Subcellular Location Annotation
messages: Cytoplasm

315358:SERIO RS03700
gene id: 315358:SERIO_RS03700
uniprot id: A0A0H3XIK6
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS06230
gene id: 315358:SERIO_RS06230
uniprot id: A0A0H3XGT8
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS02375
gene id: 315358:SERIO_RS02375
uniprot id: A0A0H3XJM7
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

315358:SERIO RS04895
gene id: 315358:SERIO_RS04895
uniprot id: A0A0H3XN26
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

315358:SERIO RS05915
gene id: 315358:SERIO_RS05915
uniprot id: A0A0H3XIL9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

315358:SERIO RS00065
gene id: 315358:SERIO_RS00065
uniprot id: A0A0H3XIQ5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

315358:SERIO RS05330
gene id: 315358:SERIO_RS05330
uniprot id: A0A0H3XN70
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Homodimer.

315358:SERIO RS00190
gene id: 315358:SERIO_RS00190
uniprot id: A0A0H3XIS4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

315358:SERIO RS01485
gene id: 315358:SERIO_RS01485
uniprot id: A0A0H3XHQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

315358:SERIO RS02420
gene id: 315358:SERIO_RS02420
uniprot id: A0A0H3XI12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

315358:SERIO RS01345
gene id: 315358:SERIO_RS01345
uniprot id: A0A0H3XKE0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

315358:SERIO RS05820
gene id: 315358:SERIO_RS05820
uniprot id: A0A0H3XLA8
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.

315358:SERIO RS01515
gene id: 315358:SERIO_RS01515
uniprot id: A0A0H3XJ94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

315358:SERIO RS06165
gene id: 315358:SERIO_RS06165
uniprot id: A0A0H3XIQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

315358:SERIO RS01415
gene id: 315358:SERIO_RS01415
uniprot id: A0A0H3XJ75
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

315358:SERIO RS00010
gene id: 315358:SERIO_RS00010
uniprot id: A0A0H3XH90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA which binds and tethers DNA polymerases and other proteins to the DNA. The DNA replisome complex has a single clamp-loading complex (3 tau and 1 each of delta, delta', psi and chi subunits) which binds 3 Pol III cores (1 core on the leading strand and 2 on the lagging strand) each with a beta sliding clamp dimer. Additional proteins in the replisome are other copies of gamma, psi and chi, Ssb, DNA helicase and RNA primase.

315358:SERIO RS02885
gene id: 315358:SERIO_RS02885
uniprot id: A0A0H3XMI8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

315358:SERIO RS05950
gene id: 315358:SERIO_RS05950
uniprot id: A0A0H3XJH1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

315358:SERIO RS00395
gene id: 315358:SERIO_RS00395
uniprot id: A0A0H3XHE1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

315358:SERIO RS04285
gene id: 315358:SERIO_RS04285
uniprot id: A0A0H3XHY1
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

315358:SERIO RS02840
gene id: 315358:SERIO_RS02840
uniprot id: A0A0H3XHH3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

315358:SERIO RS02690
gene id: 315358:SERIO_RS02690
uniprot id: A0A0H3XJS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

315358:SERIO RS03800
gene id: 315358:SERIO_RS03800
uniprot id: A0A0H3XKB0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

315358:SERIO RS02255
gene id: 315358:SERIO_RS02255
uniprot id: A0A0H3XHB2
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

315358:SERIO RS00320
gene id: 315358:SERIO_RS00320
uniprot id: A0A0H3XK10
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

315358:SERIO RS03695
gene id: 315358:SERIO_RS03695
uniprot id: A0A0H3XLC7
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

315358:SERIO RS00795
gene id: 315358:SERIO_RS00795
uniprot id: A0A0H3XHJ1
names: Similarity
messages: Belongs to the peptidase M17 family.

315358:SERIO RS02780
gene id: 315358:SERIO_RS02780
uniprot id: A0A0H3XJT6
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS01845
gene id: 315358:SERIO_RS01845
uniprot id: A0A0H3XH70
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.
messages: Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
messages: Homodimer.
messages: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.

315358:SERIO RS00860
gene id: 315358:SERIO_RS00860
uniprot id: M1LEI4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

315358:SERIO RS02395
gene id: 315358:SERIO_RS02395
uniprot id: A0A0H3XKT3
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

315358:SERIO RS00370
gene id: 315358:SERIO_RS00370
uniprot id: A0A0H3XK17
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS01625
gene id: 315358:SERIO_RS01625
uniprot id: A0A0H3XH47
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

315358:SERIO RS00550
gene id: 315358:SERIO_RS00550
uniprot id: A0A0H3XGU3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

315358:SERIO RS02105
gene id: 315358:SERIO_RS02105
uniprot id: A0A0H3XM89
names: Function
names: Similarity
messages: Belongs to the OMP decarboxylase family.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).

315358:SERIO RS04000
gene id: 315358:SERIO_RS04000
uniprot id: A0A0H3XLH9
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

315358:SERIO RS00840
gene id: 315358:SERIO_RS00840
uniprot id: A0A0H3XK84
names: Similarity
messages: Belongs to the ClpA/ClpB family.

315358:SERIO RS01540
gene id: 315358:SERIO_RS01540
uniprot id: A0A0H3XJA0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

315358:SERIO RS02465
gene id: 315358:SERIO_RS02465
uniprot id: A0A0H3XHD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

315358:SERIO RS05325
gene id: 315358:SERIO_RS05325
uniprot id: A0A0H3XKY5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

315358:SERIO RS01230
gene id: 315358:SERIO_RS01230
uniprot id: A0A0H3XJ52
names: Function
names: Similarity
messages: Belongs to the mannonate dehydratase family.
messages: Catalyzes the dehydration of D-mannonate.

315358:SERIO RS01595
gene id: 315358:SERIO_RS01595
uniprot id: A0A0H3XM25
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

315358:SERIO RS00305
gene id: 315358:SERIO_RS00305
uniprot id: A0A0H3XIT8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

315358:SERIO RS03690
gene id: 315358:SERIO_RS03690
uniprot id: A0A0H3XHR8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. RnhC subfamily.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

315358:SERIO RS01465
gene id: 315358:SERIO_RS01465
uniprot id: A0A0H3XJ84
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

315358:SERIO RS06190
gene id: 315358:SERIO_RS06190
uniprot id: A0A0H3XIQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Cell membrane
messages: Membrane

315358:SERIO RS01450
gene id: 315358:SERIO_RS01450
uniprot id: A0A0H3XH28
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

315358:SERIO RS00640
gene id: 315358:SERIO_RS00640
uniprot id: A0A0H3XIZ0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated Cas9 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer; Cas9 is inactive in the absence of the 2 guide RNAs (gRNA). Cas9 recognizes the protospacer adjacent motif (PAM) in the CRISPR repeat sequences to help distinguish self versus nonself, as targets within the bacterial CRISPR locus do not have PAMs. PAM recognition is also required for catalytic activity.
messages: Has 2 endonuclease domains. The discontinuous RuvC-like domain cleaves the target DNA noncomplementary to crRNA while the HNH nuclease domain cleaves the target DNA complementary to crRNA.
messages: Monomer. Binds crRNA and tracrRNA.

315358:SERIO RS00770
gene id: 315358:SERIO_RS00770
uniprot id: A0A0H3XK74
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

315358:SERIO RS05960
gene id: 315358:SERIO_RS05960
uniprot id: A0A0H3XNE3
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

315358:SERIO RS04080
gene id: 315358:SERIO_RS04080
uniprot id: A0A0H3XHV8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

315358:SERIO RS06075
gene id: 315358:SERIO_RS06075
uniprot id: A0A0H3XJJ2
names: Similarity
messages: Belongs to the TPP enzyme family.

315358:SERIO RS05720
gene id: 315358:SERIO_RS05720
uniprot id: A0A0H3XNB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

315358:SERIO RS00210
gene id: 315358:SERIO_RS00210
uniprot id: A0A0H3XHB7
names: Caution
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

315358:SERIO RS04510
gene id: 315358:SERIO_RS04510
uniprot id: A0A0H3XI16
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

315358:SERIO RS04840
gene id: 315358:SERIO_RS04840
uniprot id: A0A0H3XKR6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

315358:SERIO RS01080
gene id: 315358:SERIO_RS01080
uniprot id: A0A0H3XGZ1
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

315358:SERIO RS00705
gene id: 315358:SERIO_RS00705
uniprot id: A0A0H3XLS3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

315358:SERIO RS01420
gene id: 315358:SERIO_RS01420
uniprot id: A0A0H3XM01
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

315358:SERIO RS04050
gene id: 315358:SERIO_RS04050
uniprot id: A0A0H3XLI3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

315358:SERIO RS01475
gene id: 315358:SERIO_RS01475
uniprot id: A0A0H3XH31
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

315358:SERIO RS01060
gene id: 315358:SERIO_RS01060
uniprot id: A0A0H3XKA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

315358:SERIO RS01605
gene id: 315358:SERIO_RS01605
uniprot id: A0A0H3XKH3
names: Subcellular Location Annotation
messages: Cytoplasm

315358:SERIO RS04280
gene id: 315358:SERIO_RS04280
uniprot id: A0A0H3XMX0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

315358:SERIO RS00005
gene id: 315358:SERIO_RS00005
uniprot id: A0A0H3XJX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

315358:SERIO RS02895
gene id: 315358:SERIO_RS02895
uniprot id: A0A0H3XL02
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase family. ParE type 2 subfamily.
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

315358:SERIO RS00615
gene id: 315358:SERIO_RS00615
uniprot id: A0A0H3XIY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

315358:SERIO RS03935
gene id: 315358:SERIO_RS03935
uniprot id: A0A0H3XMT5
names: Function
names: Similarity
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.

315358:SERIO RS04310
gene id: 315358:SERIO_RS04310
uniprot id: A0A0H3XHY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

315358:SERIO RS00845
gene id: 315358:SERIO_RS00845
uniprot id: A0A0H3XHJ7
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

315358:SERIO RS02920
gene id: 315358:SERIO_RS02920
uniprot id: A0A0H3XL07
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

315358:SERIO RS00825
gene id: 315358:SERIO_RS00825
uniprot id: A0A0H3XJ11
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS03265
gene id: 315358:SERIO_RS03265
uniprot id: A0A0H3XK37
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS04575
gene id: 315358:SERIO_RS04575
uniprot id: A0A0H3XLN9
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 2 family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

315358:SERIO RS00875
gene id: 315358:SERIO_RS00875
uniprot id: A0A0H3XJ17
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

315358:SERIO RS00405
gene id: 315358:SERIO_RS00405
uniprot id: A0A0H3XLM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

315358:SERIO RS03130
gene id: 315358:SERIO_RS03130
uniprot id: A0A0H3XL64
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS03155
gene id: 315358:SERIO_RS03155
uniprot id: A0A0H3XL68
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

315358:SERIO RS02520
gene id: 315358:SERIO_RS02520
uniprot id: A0A0H3XKU9
names: Similarity
messages: Belongs to the TlyA family.

315358:SERIO RS01190
gene id: 315358:SERIO_RS01190
uniprot id: A0A0H3XH03
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS05810
gene id: 315358:SERIO_RS05810
uniprot id: A0A0H3XM91
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

315358:SERIO RS06175
gene id: 315358:SERIO_RS06175
uniprot id: A0A0H3XJL0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

315358:SERIO RS04350
gene id: 315358:SERIO_RS04350
uniprot id: A0A0H3XKI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

315358:SERIO RS02100
gene id: 315358:SERIO_RS02100
uniprot id: A0A0H3XJH9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm

315358:SERIO RS03185
gene id: 315358:SERIO_RS03185
uniprot id: A0A0H3XID3
names: Subcellular Location Annotation
messages: Cytoplasm

315358:SERIO RS00375
gene id: 315358:SERIO_RS00375
uniprot id: A0A0H3XHD8
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS03385
gene id: 315358:SERIO_RS03385
uniprot id: A0A0H3XMN6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

315358:SERIO RS06125
gene id: 315358:SERIO_RS06125
uniprot id: A0A0H3XJK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease M5 family.
messages: Cytoplasm
messages: Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step.

315358:SERIO RS01120
gene id: 315358:SERIO_RS01120
uniprot id: A0A0H3XJ42
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

315358:SERIO RS01315
gene id: 315358:SERIO_RS01315
uniprot id: A0A0H3XH15
names: Similarity
messages: Belongs to the FtsK/SpoIIIE/SftA family.

315358:SERIO RS01395
gene id: 315358:SERIO_RS01395
uniprot id: A0A0H3XLZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

315358:SERIO RS01490
gene id: 315358:SERIO_RS01490
uniprot id: A0A0H3XJ89
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

315358:SERIO RS01690
gene id: 315358:SERIO_RS01690
uniprot id: A0A0H3XJC6
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

315358:SERIO RS00535
gene id: 315358:SERIO_RS00535
uniprot id: A0A0H3XHG6
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

315358:SERIO RS03960
gene id: 315358:SERIO_RS03960
uniprot id: A0A0H3XMT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

315358:SERIO RS04695
gene id: 315358:SERIO_RS04695
uniprot id: A0A0H3XN08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

315358:SERIO RS02250
gene id: 315358:SERIO_RS02250
uniprot id: A0A0H3XMB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

315358:SERIO RS05150
gene id: 315358:SERIO_RS05150
uniprot id: A0A0H3XKV7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

315358:SERIO RS02640
gene id: 315358:SERIO_RS02640
uniprot id: A0A0H3XMG1
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

315358:SERIO RS00790
gene id: 315358:SERIO_RS00790
uniprot id: A0A0H3XGW4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

315358:SERIO RS03445
gene id: 315358:SERIO_RS03445
uniprot id: A0A0H3XK66
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS00945
gene id: 315358:SERIO_RS00945
uniprot id: A0A0H3XK92
names: Similarity
messages: Belongs to the thioredoxin family.

315358:SERIO RS01535
gene id: 315358:SERIO_RS01535
uniprot id: A0A0H3XHQ8
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

315358:SERIO RS03270
gene id: 315358:SERIO_RS03270
uniprot id: A0A0H3XMM5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

315358:SERIO RS01500
gene id: 315358:SERIO_RS01500
uniprot id: A0A0H3XH34
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

315358:SERIO RS00390
gene id: 315358:SERIO_RS00390
uniprot id: A0A0H3XK21
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

315358:SERIO RS05455
gene id: 315358:SERIO_RS05455
uniprot id: A0A0H3XN85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

315358:SERIO RS04440
gene id: 315358:SERIO_RS04440
uniprot id: A0A0H3XLM6
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS05025
gene id: 315358:SERIO_RS05025
uniprot id: A0A0H3XN33
names: Similarity
messages: Belongs to the SIS family. AgaS subfamily.

315358:SERIO RS01460
gene id: 315358:SERIO_RS01460
uniprot id: A0A0H3XHP9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

315358:SERIO RS04275
gene id: 315358:SERIO_RS04275
uniprot id: A0A0H3XKH6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

315358:SERIO RS06110
gene id: 315358:SERIO_RS06110
uniprot id: A0A0H3XNF8
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

315358:SERIO RS03525
gene id: 315358:SERIO_RS03525
uniprot id: A0A0H3XII1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

315358:SERIO RS01245
gene id: 315358:SERIO_RS01245
uniprot id: A0A0H3XKC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

315358:SERIO RS00015
gene id: 315358:SERIO_RS00015
uniprot id: A0A0H3XIP5
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

315358:SERIO RS01800
gene id: 315358:SERIO_RS01800
uniprot id: A0A0H3XH65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

315358:SERIO RS03455
gene id: 315358:SERIO_RS03455
uniprot id: A0A0H3XHQ0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

315358:SERIO RS05175
gene id: 315358:SERIO_RS05175
uniprot id: A0A0H3XKW2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

315358:SERIO RS04290
gene id: 315358:SERIO_RS04290
uniprot id: A0A0H3XLK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

315358:SERIO RS05900
gene id: 315358:SERIO_RS05900
uniprot id: A0A0H3XJG5
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

315358:SERIO RS05305
gene id: 315358:SERIO_RS05305
uniprot id: A0A0H3XN67
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

315358:SERIO RS02480
gene id: 315358:SERIO_RS02480
uniprot id: A0A0H3XJP3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

315358:SERIO RS04330
gene id: 315358:SERIO_RS04330
uniprot id: A0A0H3XMX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

315358:SERIO RS05155
gene id: 315358:SERIO_RS05155
uniprot id: A0A0H3XN49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

315358:SERIO RS06080
gene id: 315358:SERIO_RS06080
uniprot id: A0A0H3XLF2
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

315358:SERIO RS01250
gene id: 315358:SERIO_RS01250
uniprot id: A0A0H3XHM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

315358:SERIO RS00630
gene id: 315358:SERIO_RS00630
uniprot id: A0A0H3XK60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

315358:SERIO RS05590
gene id: 315358:SERIO_RS05590
uniprot id: A0A0H3XJA1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

315358:SERIO RS01525
gene id: 315358:SERIO_RS01525
uniprot id: A0A0H3XH37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

315358:SERIO RS01435
gene id: 315358:SERIO_RS01435
uniprot id: A0A0H3XHP6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

315358:SERIO RS05760
gene id: 315358:SERIO_RS05760
uniprot id: A0A0H3XJE8
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

315358:SERIO RS01510
gene id: 315358:SERIO_RS01510
uniprot id: A0A0H3XHQ5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

315358:SERIO RS02315
gene id: 315358:SERIO_RS02315
uniprot id: A0A0H3XKS3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

315358:SERIO RS05875
gene id: 315358:SERIO_RS05875
uniprot id: A0A0H3XJG1
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

315358:SERIO RS00675
gene id: 315358:SERIO_RS00675
uniprot id: A0A0H3XIZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

315358:SERIO RS00025
gene id: 315358:SERIO_RS00025
uniprot id: A0A0H3XGN1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

315358:SERIO RS01150
gene id: 315358:SERIO_RS01150
uniprot id: A0A0H3XHL5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

315358:SERIO RS02495
gene id: 315358:SERIO_RS02495
uniprot id: A0A0H3XKU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

315358:SERIO RS02260
gene id: 315358:SERIO_RS02260
uniprot id: A0A0H3XKR5
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

315358:SERIO RS04385
gene id: 315358:SERIO_RS04385
uniprot id: A0A0H3XHZ6
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS05220
gene id: 315358:SERIO_RS05220
uniprot id: A0A0H3XJ46
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

315358:SERIO RS01085
gene id: 315358:SERIO_RS01085
uniprot id: A0A0H3XKA6
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.

315358:SERIO RS04005
gene id: 315358:SERIO_RS04005
uniprot id: A0A0H3XIR0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane
messages: Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents.

315358:SERIO RS04530
gene id: 315358:SERIO_RS04530
uniprot id: A0A0H3XMZ4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

315358:SERIO RS05740
gene id: 315358:SERIO_RS05740
uniprot id: A0A0H3XL94
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.

315358:SERIO RS00525
gene id: 315358:SERIO_RS00525
uniprot id: A0A0H3XK48
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

315358:SERIO RS00855
gene id: 315358:SERIO_RS00855
uniprot id: M1LJI1
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

315358:SERIO RS04415
gene id: 315358:SERIO_RS04415
uniprot id: A0A0H3XLM3
names: Similarity
messages: Belongs to the peptidase M17 family.

315358:SERIO RS01405
gene id: 315358:SERIO_RS01405
uniprot id: A0A0H3XKE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

315358:SERIO RS03570
gene id: 315358:SERIO_RS03570
uniprot id: A0A0H3XII7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

315358:SERIO RS04925
gene id: 315358:SERIO_RS04925
uniprot id: A0A0H3XI71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

315358:SERIO RS04020
gene id: 315358:SERIO_RS04020
uniprot id: A0A0H3XHV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

315358:SERIO RS05280
gene id: 315358:SERIO_RS05280
uniprot id: A0A0H3XN64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

315358:SERIO RS05750
gene id: 315358:SERIO_RS05750
uniprot id: A0A0H3XIK0
names: Similarity
messages: Belongs to the agmatine deiminase family.

315358:SERIO RS00985
gene id: 315358:SERIO_RS00985
uniprot id: A0A0H3XLV2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

315358:SERIO RS02320
gene id: 315358:SERIO_RS02320
uniprot id: A0A0H3XHZ5
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

315358:SERIO RS00450
gene id: 315358:SERIO_RS00450
uniprot id: A0A0H3XIX0
names: Similarity
messages: Belongs to the IMPACT family.

315358:SERIO RS02095
gene id: 315358:SERIO_RS02095
uniprot id: A0A0H3XHW8
names: Cofactor
names: Similarity
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.

315358:SERIO RS00815
gene id: 315358:SERIO_RS00815
uniprot id: A0A0H3XK81
names: Similarity
messages: Belongs to the FBPase class 2 family.

315358:SERIO RS03650
gene id: 315358:SERIO_RS03650
uniprot id: A0A0H3XIJ7
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

315358:SERIO RS04920
gene id: 315358:SERIO_RS04920
uniprot id: A0A0H3XN28
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS01550
gene id: 315358:SERIO_RS01550
uniprot id: A0A0H3XH40
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS00880
gene id: 315358:SERIO_RS00880
uniprot id: A0A0H3XLU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

315358:SERIO RS01590
gene id: 315358:SERIO_RS01590
uniprot id: A0A0H3XJA8
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS03775
gene id: 315358:SERIO_RS03775
uniprot id: A0A0H3XKA5
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS04255
gene id: 315358:SERIO_RS04255
uniprot id: A0A0H3XMW7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

315358:SERIO RS02955
gene id: 315358:SERIO_RS02955
uniprot id: A0A0H3XJW5
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS05675
gene id: 315358:SERIO_RS05675
uniprot id: A0A0H3XNA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

315358:SERIO RS02205
gene id: 315358:SERIO_RS02205
uniprot id: A0A0H3XHA6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

315358:SERIO RS03885
gene id: 315358:SERIO_RS03885
uniprot id: A0A0H3XHT7
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Tetramer of two alpha and two beta subunits.

315358:SERIO RS01110
gene id: 315358:SERIO_RS01110
uniprot id: A0A0H3XKA9
names: Similarity
messages: Belongs to the ParB family.

315358:SERIO RS03355
gene id: 315358:SERIO_RS03355
uniprot id: A0A0H3XK51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

315358:SERIO RS00090
gene id: 315358:SERIO_RS00090
uniprot id: A0A0H3XLH5
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

315358:SERIO RS05080
gene id: 315358:SERIO_RS05080
uniprot id: A0A0H3XN40
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

315358:SERIO RS00680
gene id: 315358:SERIO_RS00680
uniprot id: A0A0H3XLS0
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

315358:SERIO RS02400
gene id: 315358:SERIO_RS02400
uniprot id: A0A0H3XI07
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.

315358:SERIO RS00560
gene id: 315358:SERIO_RS00560
uniprot id: A0A0H3XHG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

315358:SERIO RS05430
gene id: 315358:SERIO_RS05430
uniprot id: A0A0H3XN82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.
messages: Cell inner membrane
messages: Mediates magnesium influx to the cytosol.
messages: Membrane

315358:SERIO RS00020
gene id: 315358:SERIO_RS00020
uniprot id: A0A0H3XLG0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

315358:SERIO RS01340
gene id: 315358:SERIO_RS01340
uniprot id: A0A0H3XH18
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS00575
gene id: 315358:SERIO_RS00575
uniprot id: A0A0H3XGU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

315358:SERIO RS06025
gene id: 315358:SERIO_RS06025
uniprot id: A0A0H3XJI4
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS04885
gene id: 315358:SERIO_RS04885
uniprot id: A0A0H3XJ13
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

315358:SERIO RS03625
gene id: 315358:SERIO_RS03625
uniprot id: A0A0H3XIJ4
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS00725
gene id: 315358:SERIO_RS00725
uniprot id: A0A0H3XIZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

315358:SERIO RS00760
gene id: 315358:SERIO_RS00760
uniprot id: A0A0H3XLS9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

315358:SERIO RS06000
gene id: 315358:SERIO_RS06000
uniprot id: A0A0H3XJI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

315358:SERIO RS03865
gene id: 315358:SERIO_RS03865
uniprot id: A0A0H3XLG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

315358:SERIO RS06035
gene id: 315358:SERIO_RS06035
uniprot id: A0A0H3XNF0
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS04845
gene id: 315358:SERIO_RS04845
uniprot id: A0A0H3XN23
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS03220
gene id: 315358:SERIO_RS03220
uniprot id: A0A0H3XK31
names: Function
messages: Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase.

315358:SERIO RS04465
gene id: 315358:SERIO_RS04465
uniprot id: A0A0H3XLM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

315358:SERIO RS01180
gene id: 315358:SERIO_RS01180
uniprot id: A0A0H3XJ48
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

315358:SERIO RS00570
gene id: 315358:SERIO_RS00570
uniprot id: A0A0H3XLQ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

315358:SERIO RS00415
gene id: 315358:SERIO_RS00415
uniprot id: A0A0H3XK25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

315358:SERIO RS04770
gene id: 315358:SERIO_RS04770
uniprot id: A0A0H3XN16
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

315358:SERIO RS00690
gene id: 315358:SERIO_RS00690
uniprot id: A0A0H3XK65
names: Similarity
messages: Belongs to the lipase/esterase LIP3/BchO family.

315358:SERIO RS04570
gene id: 315358:SERIO_RS04570
uniprot id: A0A0H3XI23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

315358:SERIO RS05755
gene id: 315358:SERIO_RS05755
uniprot id: A0A0H3XM84
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

315358:SERIO RS03280
gene id: 315358:SERIO_RS03280
uniprot id: A0A0H3XL82
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

315358:SERIO RS05210
gene id: 315358:SERIO_RS05210
uniprot id: A0A0H3XIA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

315358:SERIO RS02645
gene id: 315358:SERIO_RS02645
uniprot id: A0A0H3XHF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

315358:SERIO RS02935
gene id: 315358:SERIO_RS02935
uniprot id: A0A0H3XMJ3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

315358:SERIO RS05205
gene id: 315358:SERIO_RS05205
uniprot id: A0A0H3XN56
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

315358:SERIO RS02410
gene id: 315358:SERIO_RS02410
uniprot id: A0A0H3XHC9
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS04315
gene id: 315358:SERIO_RS04315
uniprot id: A0A0H3XLL1
names: Caution
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

315358:SERIO RS05540
gene id: 315358:SERIO_RS05540
uniprot id: A0A0H3XL26
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

315358:SERIO RS02220
gene id: 315358:SERIO_RS02220
uniprot id: A0A0H3XJK2
names: Similarity
messages: Belongs to the RutC family.

315358:SERIO RS02330
gene id: 315358:SERIO_RS02330
uniprot id: A0A0H3XMC4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm

315358:SERIO RS06330
gene id: 315358:SERIO_RS06330
uniprot id: A0A0H3XJ43
names: Similarity
messages: Belongs to the DprA/Smf family.

315358:SERIO RS01445
gene id: 315358:SERIO_RS01445
uniprot id: A0A0H3XM04
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

315358:SERIO RS00230
gene id: 315358:SERIO_RS00230
uniprot id: A0A0H3XGQ4
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

315358:SERIO RS04380
gene id: 315358:SERIO_RS04380
uniprot id: A0A0H3XMX9
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

315358:SERIO RS01220
gene id: 315358:SERIO_RS01220
uniprot id: A0A0H3XKC3
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.

315358:SERIO RS06085
gene id: 315358:SERIO_RS06085
uniprot id: A0A0H3XNF5
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS05780
gene id: 315358:SERIO_RS05780
uniprot id: A0A0H3XM88
names: Similarity
messages: Belongs to the lipase/esterase LIP3/BchO family.

315358:SERIO RS04390
gene id: 315358:SERIO_RS04390
uniprot id: A0A0H3XLM0
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

315358:SERIO RS05395
gene id: 315358:SERIO_RS05395
uniprot id: A0A0H3XJ69
names: Similarity
messages: Belongs to the LacAB/RpiB family.

315358:SERIO RS01630
gene id: 315358:SERIO_RS01630
uniprot id: A0A0H3XKH7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

315358:SERIO RS06130
gene id: 315358:SERIO_RS06130
uniprot id: A0A0H3XLG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

315358:SERIO RS01380
gene id: 315358:SERIO_RS01380
uniprot id: A0A0H3XKE4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

315358:SERIO RS01975
gene id: 315358:SERIO_RS01975
uniprot id: A0A0H3XJG2
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS00400
gene id: 315358:SERIO_RS00400
uniprot id: A0A0H3XIV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

315358:SERIO RS05320
gene id: 315358:SERIO_RS05320
uniprot id: A0A0H3XJ57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

315358:SERIO RS02280
gene id: 315358:SERIO_RS02280
uniprot id: A0A0H3XHB6
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

315358:SERIO RS00800
gene id: 315358:SERIO_RS00800
uniprot id: A0A0H3XJ08
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

315358:SERIO RS02800
gene id: 315358:SERIO_RS02800
uniprot id: A0A0H3XI69
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS04900
gene id: 315358:SERIO_RS04900
uniprot id: A0A0H3XI68
names: Similarity
messages: Belongs to the CutC family.

315358:SERIO RS01710
gene id: 315358:SERIO_RS01710
uniprot id: A0A0H3XHS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

315358:SERIO RS06105
gene id: 315358:SERIO_RS06105
uniprot id: A0A0H3XLF5
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS02345
gene id: 315358:SERIO_RS02345
uniprot id: A0A0H3XI00
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

315358:SERIO RS04890
gene id: 315358:SERIO_RS04890
uniprot id: A0A0H3XKS4
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

315358:SERIO RS00955
gene id: 315358:SERIO_RS00955
uniprot id: A0A0H3XJ24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

315358:SERIO RS06225
gene id: 315358:SERIO_RS06225
uniprot id: A0A0H3XLP7
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS00625
gene id: 315358:SERIO_RS00625
uniprot id: A0A0H3XGU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

315358:SERIO RS06070
gene id: 315358:SERIO_RS06070
uniprot id: A0A0H3XMC3
names: Similarity
messages: Belongs to the alpha-acetolactate decarboxylase family.

315358:SERIO RS04515
gene id: 315358:SERIO_RS04515
uniprot id: A0A0H3XLN4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

315358:SERIO RS05050
gene id: 315358:SERIO_RS05050
uniprot id: A0A0H3XKU1
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

315358:SERIO RS00170
gene id: 315358:SERIO_RS00170
uniprot id: A0A0H3XLI6
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS05085
gene id: 315358:SERIO_RS05085
uniprot id: A0A0H3XI85
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS05120
gene id: 315358:SERIO_RS05120
uniprot id: A0A0H3XJ36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

315358:SERIO RS00410
gene id: 315358:SERIO_RS00410
uniprot id: A0A0H3XGS2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

315358:SERIO RS01805
gene id: 315358:SERIO_RS01805
uniprot id: A0A0H3XKK3
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

315358:SERIO RS05180
gene id: 315358:SERIO_RS05180
uniprot id: A0A0H3XN53
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

315358:SERIO RS00850
gene id: 315358:SERIO_RS00850
uniprot id: L0L9Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

315358:SERIO RS04710
gene id: 315358:SERIO_RS04710
uniprot id: A0A0H3XIZ2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

315358:SERIO RS01440
gene id: 315358:SERIO_RS01440
uniprot id: A0A0H3XJ80
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

315358:SERIO RS02415
gene id: 315358:SERIO_RS02415
uniprot id: A0A0H3XKT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

315358:SERIO RS00670
gene id: 315358:SERIO_RS00670
uniprot id: A0A0H3XHH9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

315358:SERIO RS06150
gene id: 315358:SERIO_RS06150
uniprot id: A0A0H3XJK5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

315358:SERIO RS02090
gene id: 315358:SERIO_RS02090
uniprot id: A0A0H3XKP0
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

315358:SERIO RS01425
gene id: 315358:SERIO_RS01425
uniprot id: A0A0H3XH25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

315358:SERIO RS01240
gene id: 315358:SERIO_RS01240
uniprot id: A0A0H3XH08
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

315358:SERIO RS03925
gene id: 315358:SERIO_RS03925
uniprot id: A0A0H3XIP7
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

315358:SERIO RS00045
gene id: 315358:SERIO_RS00045
uniprot id: A0A0H3XLG5
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

315358:SERIO RS05000
gene id: 315358:SERIO_RS05000
uniprot id: A0A0H3XI74
names: Similarity
messages: Belongs to the asp23 family.

315358:SERIO RS00480
gene id: 315358:SERIO_RS00480
uniprot id: A0A0H3XIX3
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

315358:SERIO RS00035
gene id: 315358:SERIO_RS00035
uniprot id: A0A0H3XH94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

315358:SERIO RS00430
gene id: 315358:SERIO_RS00430
uniprot id: A0A0H3XLM7
names: Cofactor
messages: Binds 1 zinc ion per subunit.

315358:SERIO RS05295
gene id: 315358:SERIO_RS05295
uniprot id: A0A0H3XJ55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

315358:SERIO RS05570
gene id: 315358:SERIO_RS05570
uniprot id: A0A0H3XL32
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS01860
gene id: 315358:SERIO_RS01860
uniprot id: A0A0H3XKK8
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

315358:SERIO RS01810
gene id: 315358:SERIO_RS01810
uniprot id: A0A0H3XHT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

315358:SERIO RS02975
gene id: 315358:SERIO_RS02975
uniprot id: A0A0H3XI91
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS03790
gene id: 315358:SERIO_RS03790
uniprot id: A0A0H3XLE9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

315358:SERIO RS04555
gene id: 315358:SERIO_RS04555
uniprot id: A0A0H3XIX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

315358:SERIO RS02290
gene id: 315358:SERIO_RS02290
uniprot id: A0A0H3XHZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

315358:SERIO RS02165
gene id: 315358:SERIO_RS02165
uniprot id: A0A0H3XKQ2
names: Similarity
messages: Belongs to the DEAD box helicase family.

315358:SERIO RS03315
gene id: 315358:SERIO_RS03315
uniprot id: A0A0H3XK45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

315358:SERIO RS04860
gene id: 315358:SERIO_RS04860
uniprot id: A0A0H3XJ10
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS01335
gene id: 315358:SERIO_RS01335
uniprot id: A0A0H3XLZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).

315358:SERIO RS00270
gene id: 315358:SERIO_RS00270
uniprot id: A0A0H3XK03
names: Similarity
messages: Belongs to the LacAB/RpiB family.

315358:SERIO RS04215
gene id: 315358:SERIO_RS04215
uniprot id: A0A0H3XLJ8
names: Subcellular Location Annotation
messages: cytosol

315358:SERIO RS03930
gene id: 315358:SERIO_RS03930
uniprot id: A0A0H3XKD0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

315358:SERIO RS03560
gene id: 315358:SERIO_RS03560
uniprot id: A0A0H3XHQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

315358:SERIO RS04755
gene id: 315358:SERIO_RS04755
uniprot id: A0A0H3XLR7
names: Subcellular Location Annotation
messages: Cytoplasm

315358:SERIO RS02265
gene id: 315358:SERIO_RS02265
uniprot id: A0A0H3XHY9
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.

315358:SERIO RS03660
gene id: 315358:SERIO_RS03660
uniprot id: A0A0H3XMQ6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

315358:SERIO RS03335
gene id: 315358:SERIO_RS03335
uniprot id: A0A0H3XMN1
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS04370
gene id: 315358:SERIO_RS04370
uniprot id: A0A0H3XIV5
names: Similarity
messages: Belongs to the Lgt family.

315358:SERIO RS02905
gene id: 315358:SERIO_RS02905
uniprot id: A0A0H3XJV5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

315358:SERIO RS04100
gene id: 315358:SERIO_RS04100
uniprot id: A0A0H3XMV1
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS03705
gene id: 315358:SERIO_RS03705
uniprot id: A0A0H3XK98
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

315358:SERIO RS05225
gene id: 315358:SERIO_RS05225
uniprot id: A0A0H3XKW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

315358:SERIO RS04305
gene id: 315358:SERIO_RS04305
uniprot id: A0A0H3XMX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. PolC subfamily.
messages: Cytoplasm
messages: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

315358:SERIO RS03580
gene id: 315358:SERIO_RS03580
uniprot id: A0A0H3XMP8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

315358:SERIO RS00620
gene id: 315358:SERIO_RS00620
uniprot id: A0A0H3XLR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

315358:SERIO RS03710
gene id: 315358:SERIO_RS03710
uniprot id: A0A0H3XMR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

315358:SERIO RS03460
gene id: 315358:SERIO_RS03460
uniprot id: A0A0H3XLA0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

315358:SERIO RS03035
gene id: 315358:SERIO_RS03035
uniprot id: A0A0H3XMK2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

315358:SERIO RS00510
gene id: 315358:SERIO_RS00510
uniprot id: A0A0H3XIX7
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

315358:SERIO RS05355
gene id: 315358:SERIO_RS05355
uniprot id: A0A0H3XN73
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS01885
gene id: 315358:SERIO_RS01885
uniprot id: A0A0H3XKL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VirD4/TraG family.
messages: Membrane

315358:SERIO RS01430
gene id: 315358:SERIO_RS01430
uniprot id: A0A0H3XKF0
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

315358:SERIO RS04850
gene id: 315358:SERIO_RS04850
uniprot id: A0A0H3XI61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

315358:SERIO RS02085
gene id: 315358:SERIO_RS02085
uniprot id: A0A0H3XH93
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

315358:SERIO RS00040
gene id: 315358:SERIO_RS00040
uniprot id: A0A0H3XIQ0
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

315358:SERIO RS02845
gene id: 315358:SERIO_RS02845
uniprot id: A0A0H3XKZ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

315358:SERIO RS01115
gene id: 315358:SERIO_RS01115
uniprot id: A0A0H3XHL3
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

315358:SERIO RS05310
gene id: 315358:SERIO_RS05310
uniprot id: A0A0H3XIB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

315358:SERIO RS05335
gene id: 315358:SERIO_RS05335
uniprot id: A0A0H3XIB5
names: Similarity
messages: Belongs to the Lgt family.

315358:SERIO RS01035
gene id: 315358:SERIO_RS01035
uniprot id: A0A0H3XK99
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS00205
gene id: 315358:SERIO_RS00205
uniprot id: A0A0H3XJZ6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

315358:SERIO RS04335
gene id: 315358:SERIO_RS04335
uniprot id: A0A0H3XHY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

315358:SERIO RS05805
gene id: 315358:SERIO_RS05805
uniprot id: A0A0H3XIK7
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

315358:SERIO RS01980
gene id: 315358:SERIO_RS01980
uniprot id: A0A0H3XM74
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS03875
gene id: 315358:SERIO_RS03875
uniprot id: A0A0H3XKC1
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

315358:SERIO RS00960
gene id: 315358:SERIO_RS00960
uniprot id: A0A0H3XLV1
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS03985
gene id: 315358:SERIO_RS03985
uniprot id: A0A0H3XKD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

315358:SERIO RS02460
gene id: 315358:SERIO_RS02460
uniprot id: A0A0H3XME2
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS05130
gene id: 315358:SERIO_RS05130
uniprot id: A0A0H3XN46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

315358:SERIO RS04800
gene id: 315358:SERIO_RS04800
uniprot id: A0A0H3XI55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

315358:SERIO RS02360
gene id: 315358:SERIO_RS02360
uniprot id: A0A0H3XHC3
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS03795
gene id: 315358:SERIO_RS03795
uniprot id: A0A0H3XIM4
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS00325
gene id: 315358:SERIO_RS00325
uniprot id: A0A0H3XHD2
names: Function
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

315358:SERIO RS05240
gene id: 315358:SERIO_RS05240
uniprot id: A0A0H3XLY9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

315358:SERIO RS02335
gene id: 315358:SERIO_RS02335
uniprot id: A0A0H3XHC0
names: Similarity
messages: In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
messages: In the N-terminal section; belongs to the aldehyde dehydrogenase family.

315358:SERIO RS00260
gene id: 315358:SERIO_RS00260
uniprot id: A0A0H3XLK0
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

315358:SERIO RS00185
gene id: 315358:SERIO_RS00185
uniprot id: A0A0H3XHB4
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

315358:SERIO RS05055
gene id: 315358:SERIO_RS05055
uniprot id: A0A0H3XN37
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

315358:SERIO RS00435
gene id: 315358:SERIO_RS00435
uniprot id: A0A0H3XGS5
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

315358:SERIO RS05490
gene id: 315358:SERIO_RS05490
uniprot id: A0A0H3XM30
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

315358:SERIO RS00730
gene id: 315358:SERIO_RS00730
uniprot id: A0A0H3XLS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

315358:SERIO RS01305
gene id: 315358:SERIO_RS01305
uniprot id: A0A0H3XJ59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

315358:SERIO RS00265
gene id: 315358:SERIO_RS00265
uniprot id: A0A0H3XGQ5
names: Similarity
messages: Belongs to the LacAB/RpiB family.

315358:SERIO RS05745
gene id: 315358:SERIO_RS05745
uniprot id: A0A0H3XNC8
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS02685
gene id: 315358:SERIO_RS02685
uniprot id: A0A0H3XI50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

315358:SERIO RS06045
gene id: 315358:SERIO_RS06045
uniprot id: A0A0H3XMB9
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS00215
gene id: 315358:SERIO_RS00215
uniprot id: A0A0H3XIS8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

315358:SERIO RS03675
gene id: 315358:SERIO_RS03675
uniprot id: A0A0H3XIK2
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

315358:SERIO RS04825
gene id: 315358:SERIO_RS04825
uniprot id: A0A0H3XI58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

315358:SERIO RS05830
gene id: 315358:SERIO_RS05830
uniprot id: A0A0H3XIL0
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

315358:SERIO RS03150
gene id: 315358:SERIO_RS03150
uniprot id: A0A0H3XHM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

315358:SERIO RS01300
gene id: 315358:SERIO_RS01300
uniprot id: A0A0H3XHN3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

315358:SERIO RS04520
gene id: 315358:SERIO_RS04520
uniprot id: A0A0H3XIW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

315358:SERIO RS01505
gene id: 315358:SERIO_RS01505
uniprot id: A0A0H3XKF9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

315358:SERIO RS01610
gene id: 315358:SERIO_RS01610
uniprot id: A0A0H3XHR6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

315358:SERIO RS03670
gene id: 315358:SERIO_RS03670
uniprot id: A0A0H3XLC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

315358:SERIO RS00950
gene id: 315358:SERIO_RS00950
uniprot id: A0A0H3XHK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arginine deiminase family.
messages: Cytoplasm

315358:SERIO RS05725
gene id: 315358:SERIO_RS05725
uniprot id: A0A0H3XIH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

315358:SERIO RS04435
gene id: 315358:SERIO_RS04435
uniprot id: A0A0H3XI03
names: Similarity
messages: Belongs to the peptidase M17 family.

315358:SERIO RS03655
gene id: 315358:SERIO_RS03655
uniprot id: A0A0H3XK91
names: Similarity
messages: Belongs to the pyruvate kinase family.

315358:SERIO RS04780
gene id: 315358:SERIO_RS04780
uniprot id: A0A0H3XLS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

315358:SERIO RS02110
gene id: 315358:SERIO_RS02110
uniprot id: A0A0H3XH96
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

315358:SERIO RS02620
gene id: 315358:SERIO_RS02620
uniprot id: A0A0H3XHE9
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

315358:SERIO RS04915
gene id: 315358:SERIO_RS04915
uniprot id: A0A0H3XKS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

315358:SERIO RS05605
gene id: 315358:SERIO_RS05605
uniprot id: A0A0H3XIF6
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

315358:SERIO RS04705
gene id: 315358:SERIO_RS04705
uniprot id: A0A0H3XLQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

315358:SERIO RS05940
gene id: 315358:SERIO_RS05940
uniprot id: A0A0H3XIM3
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

315358:SERIO RS00385
gene id: 315358:SERIO_RS00385
uniprot id: A0A0H3XGS0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

315358:SERIO RS05520
gene id: 315358:SERIO_RS05520
uniprot id: A0A0H3XN91
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

315358:SERIO RS03540
gene id: 315358:SERIO_RS03540
uniprot id: A0A0H3XHQ4
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS05955
gene id: 315358:SERIO_RS05955
uniprot id: A0A0H3XLD2
names: Similarity
messages: Belongs to the IMPACT family.

315358:SERIO RS04605
gene id: 315358:SERIO_RS04605
uniprot id: A0A0H3XIX8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

315358:SERIO RS00565
gene id: 315358:SERIO_RS00565
uniprot id: A0A0H3XIY2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

315358:SERIO RS04340
gene id: 315358:SERIO_RS04340
uniprot id: A0A0H3XLL5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

315358:SERIO RS06095
gene id: 315358:SERIO_RS06095
uniprot id: A0A0H3XMC7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

315358:SERIO RS02605
gene id: 315358:SERIO_RS02605
uniprot id: A0A0H3XI39
names: Similarity
messages: Belongs to the type IA topoisomerase family.

315358:SERIO RS02700
gene id: 315358:SERIO_RS02700
uniprot id: A0A0H3XHF6
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Homodimer.

315358:SERIO RS01675
gene id: 315358:SERIO_RS01675
uniprot id: A0A0H3XH53
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

315358:SERIO RS05340
gene id: 315358:SERIO_RS05340
uniprot id: A0A0H3XM06
names: Similarity
messages: Belongs to the HPrK/P family.

315358:SERIO RS01520
gene id: 315358:SERIO_RS01520
uniprot id: A0A0H3XM15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

315358:SERIO RS00885
gene id: 315358:SERIO_RS00885
uniprot id: A0A0H3XGX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

315358:SERIO RS05115
gene id: 315358:SERIO_RS05115
uniprot id: A0A0H3XLW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

315358:SERIO RS05550
gene id: 315358:SERIO_RS05550
uniprot id: A0A0H3XIE8
names: Subcellular Location Annotation
messages: Membrane

315358:SERIO RS05035
gene id: 315358:SERIO_RS05035
uniprot id: A0A0H3XLV4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

315358:SERIO RS04930
gene id: 315358:SERIO_RS04930
uniprot id: A0A0H3XLU5
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

315358:SERIO RS01530
gene id: 315358:SERIO_RS01530
uniprot id: A0A0H3XKG2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

315358:SERIO RS03715
gene id: 315358:SERIO_RS03715
uniprot id: A0A0H3XHS0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

315358:SERIO RS01685
gene id: 315358:SERIO_RS01685
uniprot id: A0A0H3XHS3
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

315358:SERIO RS00735
gene id: 315358:SERIO_RS00735
uniprot id: A0A0H3XGV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

315358:SERIO RS00965
gene id: 315358:SERIO_RS00965
uniprot id: A0A0H3XGY0
names: Similarity
messages: Belongs to the carbamate kinase family.

315358:SERIO RS03880
gene id: 315358:SERIO_RS03880
uniprot id: A0A0H3XMT0
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

315358:SERIO RS05100
gene id: 315358:SERIO_RS05100
uniprot id: A0A0H3XKU8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

315358:SERIO RS05715
gene id: 315358:SERIO_RS05715
uniprot id: A0A0H3XL63
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

315358:SERIO RS02860
gene id: 315358:SERIO_RS02860
uniprot id: A0A0H3XMI5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

315358:SERIO RS03755
gene id: 315358:SERIO_RS03755
uniprot id: A0A0H3XKA3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

315358:SERIO RS01165
gene id: 315358:SERIO_RS01165
uniprot id: A0A0H3XH00
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

315358:SERIO RS02500
gene id: 315358:SERIO_RS02500
uniprot id: A0A0H3XI24
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.