2995174:OSC50 RS18135
gene id: 2995174:OSC50_RS18135
uniprot id: A0A9E8GL89
names: Subcellular Location Annotation
messages: Cytoplasm

2995174:OSC50 RS01720
gene id: 2995174:OSC50_RS01720
uniprot id: A0A9E8GQH7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

2995174:OSC50 RS01870
gene id: 2995174:OSC50_RS01870
uniprot id: A0A9E8GIG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

2995174:OSC50 RS06820
gene id: 2995174:OSC50_RS06820
uniprot id: A0A9E8GZF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgI family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

2995174:OSC50 RS25785
gene id: 2995174:OSC50_RS25785
uniprot id: A0A9E8K6X7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiD family.
messages: Binds 1 prenylated FMN (prenyl-FMN) per subunit.
messages: Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
messages: Cell membrane
messages: Homohexamer.

2995174:OSC50 RS01850
gene id: 2995174:OSC50_RS01850
uniprot id: A0A9E8GQL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

2995174:OSC50 RS09435
gene id: 2995174:OSC50_RS09435
uniprot id: A0A9E8GXC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HflD family.
messages: Cell membrane
messages: Cytoplasm

2995174:OSC50 RS14790
gene id: 2995174:OSC50_RS14790
uniprot id: A0A9E8GKK1
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

2995174:OSC50 RS01840
gene id: 2995174:OSC50_RS01840
uniprot id: A0A9E8GPV1
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

2995174:OSC50 RS19080
gene id: 2995174:OSC50_RS19080
uniprot id: A0A9E8GTF3
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.

2995174:OSC50 RS16415
gene id: 2995174:OSC50_RS16415
uniprot id: A0A9E8GV63
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

2995174:OSC50 RS01690
gene id: 2995174:OSC50_RS01690
uniprot id: A0A9E8GPT2
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

2995174:OSC50 RS03545
gene id: 2995174:OSC50_RS03545
uniprot id: A0A9E8GXQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
messages: Heterooctamer of two A chains, two B chains, two C chains and two D chains.
messages: Membrane

2995174:OSC50 RS25775
gene id: 2995174:OSC50_RS25775
uniprot id: A0A9E8K5X8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.

2995174:OSC50 RS01830
gene id: 2995174:OSC50_RS01830
uniprot id: A0A9E8GZH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

2995174:OSC50 RS03730
gene id: 2995174:OSC50_RS03730
uniprot id: A0A9E8GQE3
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.

2995174:OSC50 RS17260
gene id: 2995174:OSC50_RS17260
uniprot id: A0A9E8GZA9
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

2995174:OSC50 RS21050
gene id: 2995174:OSC50_RS21050
uniprot id: A0A9E8GT00
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein bS18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2995174:OSC50 RS09350
gene id: 2995174:OSC50_RS09350
uniprot id: A0A9E8GK77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

2995174:OSC50 RS24165
gene id: 2995174:OSC50_RS24165
uniprot id: A0A9E8GUY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0391 family.
messages: Cell membrane

2995174:OSC50 RS01800
gene id: 2995174:OSC50_RS01800
uniprot id: A0A9E8GK64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

2995174:OSC50 RS25265
gene id: 2995174:OSC50_RS25265
uniprot id: A0A9E8KHW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Cell membrane
messages: Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
messages: Membrane
messages: The accessory proteins ExbB and ExbD seem to form a complex with TonB.

2995174:OSC50 RS17965
gene id: 2995174:OSC50_RS17965
uniprot id: A0A9E8GX94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

2995174:OSC50 RS25925
gene id: 2995174:OSC50_RS25925
uniprot id: A0A9E8GZ01
names: Similarity
messages: Belongs to the band 7/mec-2 family.

2995174:OSC50 RS02295
gene id: 2995174:OSC50_RS02295
uniprot id: A0A9E8H850
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

2995174:OSC50 RS03670
gene id: 2995174:OSC50_RS03670
uniprot id: A0A9E8GJ43
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

2995174:OSC50 RS01780
gene id: 2995174:OSC50_RS01780
uniprot id: A0A9E8GRQ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

2995174:OSC50 RS05675
gene id: 2995174:OSC50_RS05675
uniprot id: A0A9E8H6X7
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

2995174:OSC50 RS08205
gene id: 2995174:OSC50_RS08205
uniprot id: A0A9E8K9L1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

2995174:OSC50 RS03695
gene id: 2995174:OSC50_RS03695
uniprot id: A0A9E8K8R4
names: Function
names: Similarity
messages: A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
messages: Belongs to the NifU family.

2995174:OSC50 RS21730
gene id: 2995174:OSC50_RS21730
uniprot id: A0A9E8GN13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

2995174:OSC50 RS25955
gene id: 2995174:OSC50_RS25955
uniprot id: A0A9E8K832
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. ArgA subfamily.
messages: Cytoplasm

2995174:OSC50 RS21835
gene id: 2995174:OSC50_RS21835
uniprot id: A0A9E8H6U1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

2995174:OSC50 RS16130
gene id: 2995174:OSC50_RS16130
uniprot id: A0A9E8H644
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

2995174:OSC50 RS01265
gene id: 2995174:OSC50_RS01265
uniprot id: A0A9E8GRW9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PqqD family.
messages: Functions as a PqqA binding protein and presents PqqA to PqqE, in the pyrroloquinoline quinone (PQQ) biosynthetic pathway.
messages: Monomer. Interacts with PqqE.

2995174:OSC50 RS25295
gene id: 2995174:OSC50_RS25295
uniprot id: A0A9E8GRA0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

2995174:OSC50 RS22810
gene id: 2995174:OSC50_RS22810
uniprot id: A0A9E8KFM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

2995174:OSC50 RS20280
gene id: 2995174:OSC50_RS20280
uniprot id: A0A9E8K4X4
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

2995174:OSC50 RS20135
gene id: 2995174:OSC50_RS20135
uniprot id: A0A9E8HBA7
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

2995174:OSC50 RS04395
gene id: 2995174:OSC50_RS04395
uniprot id: A0A9E8GRC3
names: Similarity
messages: Belongs to the UPF0234 family.

2995174:OSC50 RS20570
gene id: 2995174:OSC50_RS20570
uniprot id: A0A9E8H261
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PAPS reductase family. CysD subfamily.
messages: Heterodimer composed of CysD, the smaller subunit, and CysN.
messages: With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

2995174:OSC50 RS25080
gene id: 2995174:OSC50_RS25080
uniprot id: A0A9E8K297
names: Function
messages: This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.

2995174:OSC50 RS07985
gene id: 2995174:OSC50_RS07985
uniprot id: A0A9E8GNE5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

2995174:OSC50 RS25505
gene id: 2995174:OSC50_RS25505
uniprot id: A0A9E8GW98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiK family.
messages: Cytoplasm
messages: Required for efficient ubiquinone (coenzyme Q) biosynthesis. UbiK is probably an accessory factor of Ubi enzymes and facilitates ubiquinone biosynthesis by acting as an assembly factor, a targeting factor, or both.

2995174:OSC50 RS00030
gene id: 2995174:OSC50_RS00030
uniprot id: A0A9E8K5S2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2995174:OSC50 RS24105
gene id: 2995174:OSC50_RS24105
uniprot id: A0A9E8KI52
names: Subcellular Location Annotation
messages: Membrane

2995174:OSC50 RS15965
gene id: 2995174:OSC50_RS15965
uniprot id: A0A9E8KES3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ElaB/YgaM/YqjD family.
messages: Cell inner membrane
messages: Membrane

2995174:OSC50 RS04560
gene id: 2995174:OSC50_RS04560
uniprot id: A0A9E8GRA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

2995174:OSC50 RS19030
gene id: 2995174:OSC50_RS19030
uniprot id: A0A9E8KC77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

2995174:OSC50 RS13550
gene id: 2995174:OSC50_RS13550
uniprot id: A0A9E8GVA5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2995174:OSC50 RS25005
gene id: 2995174:OSC50_RS25005
uniprot id: A0A9E8H9C0
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

2995174:OSC50 RS17705
gene id: 2995174:OSC50_RS17705
uniprot id: A0A9E8GEP9
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

2995174:OSC50 RS20035
gene id: 2995174:OSC50_RS20035
uniprot id: A0A9E8H6A6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

2995174:OSC50 RS24250
gene id: 2995174:OSC50_RS24250
uniprot id: A0A9E8GNI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

2995174:OSC50 RS11575
gene id: 2995174:OSC50_RS11575
uniprot id: A0A9E8GKX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

2995174:OSC50 RS03980
gene id: 2995174:OSC50_RS03980
uniprot id: A0A9E8GJ93
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

2995174:OSC50 RS23795
gene id: 2995174:OSC50_RS23795
uniprot id: A0A9E8H668
names: Function
names: Similarity
messages: Belongs to the CsgG family.
messages: May be involved in the biogenesis of curli organelles.

2995174:OSC50 RS14025
gene id: 2995174:OSC50_RS14025
uniprot id: A0A9E8GGX8
names: Similarity
messages: Belongs to the HicA mRNA interferase family.

2995174:OSC50 RS03365
gene id: 2995174:OSC50_RS03365
uniprot id: A0A9E8H7R6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

2995174:OSC50 RS01710
gene id: 2995174:OSC50_RS01710
uniprot id: A0A9E8H3I5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

2995174:OSC50 RS21710
gene id: 2995174:OSC50_RS21710
uniprot id: A0A9E8GFN1
names: Similarity
messages: Belongs to the transcriptional regulatory Fis family.

2995174:OSC50 RS14985
gene id: 2995174:OSC50_RS14985
uniprot id: A0A9E8K0Q1
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

2995174:OSC50 RS20235
gene id: 2995174:OSC50_RS20235
uniprot id: A0A9E8H3C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

2995174:OSC50 RS02095
gene id: 2995174:OSC50_RS02095
uniprot id: A0A9E8GHM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

2995174:OSC50 RS07180
gene id: 2995174:OSC50_RS07180
uniprot id: A0A9E8GXQ7
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

2995174:OSC50 RS04470
gene id: 2995174:OSC50_RS04470
uniprot id: A0A9E8GZT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbB/TolQ family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

2995174:OSC50 RS19015
gene id: 2995174:OSC50_RS19015
uniprot id: A0A9E8KE90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

2995174:OSC50 RS00435
gene id: 2995174:OSC50_RS00435
uniprot id: A0A9E8GZZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

2995174:OSC50 RS08915
gene id: 2995174:OSC50_RS08915
uniprot id: A0A9E8GPI6
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.

2995174:OSC50 RS01815
gene id: 2995174:OSC50_RS01815
uniprot id: A0A9E8K2R1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

2995174:OSC50 RS08195
gene id: 2995174:OSC50_RS08195
uniprot id: A0A9E8K3U0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

2995174:OSC50 RS01835
gene id: 2995174:OSC50_RS01835
uniprot id: A0A9E8KER2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

2995174:OSC50 RS04455
gene id: 2995174:OSC50_RS04455
uniprot id: A0A9E8GZ54
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

2995174:OSC50 RS18045
gene id: 2995174:OSC50_RS18045
uniprot id: A0A9E8GVX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

2995174:OSC50 RS00085
gene id: 2995174:OSC50_RS00085
uniprot id: A0A9E8H5E8
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

2995174:OSC50 RS16855
gene id: 2995174:OSC50_RS16855
uniprot id: A0A9E8HCA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfur carrier protein TusA family.
messages: Cytoplasm
messages: Sulfur carrier protein which probably makes part of a sulfur-relay system.

2995174:OSC50 RS19860
gene id: 2995174:OSC50_RS19860
uniprot id: A0A9E8GEY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

2995174:OSC50 RS01745
gene id: 2995174:OSC50_RS01745
uniprot id: A0A9E8K8F2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

2995174:OSC50 RS24685
gene id: 2995174:OSC50_RS24685
uniprot id: A0A9E8KD67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

2995174:OSC50 RS16110
gene id: 2995174:OSC50_RS16110
uniprot id: A0A9E8H8L9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2995174:OSC50 RS01695
gene id: 2995174:OSC50_RS01695
uniprot id: A0A9E8GYE0
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

2995174:OSC50 RS19315
gene id: 2995174:OSC50_RS19315
uniprot id: A0A9E8KH21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

2995174:OSC50 RS24560
gene id: 2995174:OSC50_RS24560
uniprot id: A0A9E8KI19
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

2995174:OSC50 RS07375
gene id: 2995174:OSC50_RS07375
uniprot id: A0A9E8GJQ7
names: Subcellular Location Annotation
messages: Membrane

2995174:OSC50 RS07185
gene id: 2995174:OSC50_RS07185
uniprot id: A0A9E8K6V6
names: Function
names: Similarity
names: Subunit
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.
messages: Interacts with MinC and FtsZ.

2995174:OSC50 RS22705
gene id: 2995174:OSC50_RS22705
uniprot id: A0A9E8K558
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

2995174:OSC50 RS08225
gene id: 2995174:OSC50_RS08225
uniprot id: A0A9E8GZK1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

2995174:OSC50 RS24705
gene id: 2995174:OSC50_RS24705
uniprot id: A0A9E8GGG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

2995174:OSC50 RS24610
gene id: 2995174:OSC50_RS24610
uniprot id: A0A9E8H2W5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

2995174:OSC50 RS06055
gene id: 2995174:OSC50_RS06055
uniprot id: A0A9E8GNH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribosome modulation factor family.
messages: Cytoplasm
messages: During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes).

2995174:OSC50 RS01785
gene id: 2995174:OSC50_RS01785
uniprot id: A0A9E8GHI4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

2995174:OSC50 RS02045
gene id: 2995174:OSC50_RS02045
uniprot id: A0A9E8K5U2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

2995174:OSC50 RS19930
gene id: 2995174:OSC50_RS19930
uniprot id: A0A9E8GTG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptA family.
messages: Component of the lipopolysaccharide transport and assembly complex.
messages: Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.
messages: Periplasm

2995174:OSC50 RS01385
gene id: 2995174:OSC50_RS01385
uniprot id: A0A9E8K5Q2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

2995174:OSC50 RS00650
gene id: 2995174:OSC50_RS00650
uniprot id: A0A9E8GYR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0312 family. Type 1 subfamily.
messages: Periplasm

2995174:OSC50 RS21980
gene id: 2995174:OSC50_RS21980
uniprot id: A0A9E8GSF3
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

2995174:OSC50 RS20130
gene id: 2995174:OSC50_RS20130
uniprot id: A0A9E8H2T0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

2995174:OSC50 RS09390
gene id: 2995174:OSC50_RS09390
uniprot id: A0A9E8KG34
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

2995174:OSC50 RS02910
gene id: 2995174:OSC50_RS02910
uniprot id: A0A9E8GQ87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

2995174:OSC50 RS07795
gene id: 2995174:OSC50_RS07795
uniprot id: A0A9E8GZQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

2995174:OSC50 RS18005
gene id: 2995174:OSC50_RS18005
uniprot id: A0A9E8GE92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

2995174:OSC50 RS20230
gene id: 2995174:OSC50_RS20230
uniprot id: A0A9E8GWF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

2995174:OSC50 RS08185
gene id: 2995174:OSC50_RS08185
uniprot id: A0A9E8GXE8
names: Subcellular Location Annotation
messages: Cytoplasm

2995174:OSC50 RS00265
gene id: 2995174:OSC50_RS00265
uniprot id: A0A9E8H8V6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

2995174:OSC50 RS22990
gene id: 2995174:OSC50_RS22990
uniprot id: A0A9E8GTE5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm
messages: Oligomer of 12 subunits arranged in the form of two hexagons.

2995174:OSC50 RS01775
gene id: 2995174:OSC50_RS01775
uniprot id: A0A9E8GHH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

2995174:OSC50 RS00135
gene id: 2995174:OSC50_RS00135
uniprot id: A0A9E8KK38
names: Function
names: Similarity
messages: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
messages: Belongs to the Nudix hydrolase family. RppH subfamily.

2995174:OSC50 RS15635
gene id: 2995174:OSC50_RS15635
uniprot id: A0A9E8GKV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioester dehydratase family. FabA subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.

2995174:OSC50 RS02175
gene id: 2995174:OSC50_RS02175
uniprot id: A0A9E8GQH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

2995174:OSC50 RS20175
gene id: 2995174:OSC50_RS20175
uniprot id: A0A9E8GF22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZapG family.
messages: Cell inner membrane
messages: Membrane

2995174:OSC50 RS18015
gene id: 2995174:OSC50_RS18015
uniprot id: A0A9E8KBT3
names: Similarity
messages: Belongs to the Skp family.

2995174:OSC50 RS19935
gene id: 2995174:OSC50_RS19935
uniprot id: A0A9E8GEZ3
names: Function
names: Similarity
messages: Belongs to the ABC transporter superfamily. Outer membrane lipopolysaccharide export (TC 1.B.42) family.
messages: Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system.

2995174:OSC50 RS17895
gene id: 2995174:OSC50_RS17895
uniprot id: A0A9E8GE86
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2995174:OSC50 RS01880
gene id: 2995174:OSC50_RS01880
uniprot id: A0A9E8K6A9
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

2995174:OSC50 RS09475
gene id: 2995174:OSC50_RS09475
uniprot id: A0A9E8K9S6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

2995174:OSC50 RS01820
gene id: 2995174:OSC50_RS01820
uniprot id: A0A9E8KAJ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

2995174:OSC50 RS09360
gene id: 2995174:OSC50_RS09360
uniprot id: A0A9E8GXD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2995174:OSC50 RS24665
gene id: 2995174:OSC50_RS24665
uniprot id: A0A9E8H4M7
names: Function
names: Similarity
messages: Belongs to the ParB family.
messages: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.

2995174:OSC50 RS02975
gene id: 2995174:OSC50_RS02975
uniprot id: A0A9E8GHW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

2995174:OSC50 RS20460
gene id: 2995174:OSC50_RS20460
uniprot id: A0A9E8K4C0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

2995174:OSC50 RS05495
gene id: 2995174:OSC50_RS05495
uniprot id: A0A9E8GRE6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

2995174:OSC50 RS03725
gene id: 2995174:OSC50_RS03725
uniprot id: A0A9E8GI49
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

2995174:OSC50 RS01700
gene id: 2995174:OSC50_RS01700
uniprot id: A0A9E8GHG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

2995174:OSC50 RS00720
gene id: 2995174:OSC50_RS00720
uniprot id: A0A9E8GH56
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2995174:OSC50 RS04750
gene id: 2995174:OSC50_RS04750
uniprot id: A0A9E8KF15
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

2995174:OSC50 RS26005
gene id: 2995174:OSC50_RS26005
uniprot id: A0A9E8GHP3
names: Similarity
messages: Belongs to the glutamine synthetase family.

2995174:OSC50 RS02615
gene id: 2995174:OSC50_RS02615
uniprot id: A0A9E8GZQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

2995174:OSC50 RS00755
gene id: 2995174:OSC50_RS00755
uniprot id: A0A9E8H0C3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
messages: One is catalytic and the other provides a structural contribution.

2995174:OSC50 RS03550
gene id: 2995174:OSC50_RS03550
uniprot id: A0A9E8KF70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase bacterial subunit 4 family.
messages: Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
messages: Heterooctamer of two A chains, two B chains, two C chains and two D chains.
messages: Membrane

2995174:OSC50 RS02325
gene id: 2995174:OSC50_RS02325
uniprot id: A0A9E8KAY2
names: Similarity
messages: Belongs to the UPF0250 family.

2995174:OSC50 RS24680
gene id: 2995174:OSC50_RS24680
uniprot id: A0A9E8H178
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

2995174:OSC50 RS21940
gene id: 2995174:OSC50_RS21940
uniprot id: A0A9E8GFR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

2995174:OSC50 RS24710
gene id: 2995174:OSC50_RS24710
uniprot id: A0A9E8GTH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

2995174:OSC50 RS25510
gene id: 2995174:OSC50_RS25510
uniprot id: A0A9E8GRF5
names: Similarity
messages: Belongs to the P(II) protein family.

2995174:OSC50 RS15720
gene id: 2995174:OSC50_RS15720
uniprot id: A0A9E8GHK2
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

2995174:OSC50 RS08210
gene id: 2995174:OSC50_RS08210
uniprot id: A0A9E8KE86
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

2995174:OSC50 RS25030
gene id: 2995174:OSC50_RS25030
uniprot id: A0A9E8GGL1
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

2995174:OSC50 RS01770
gene id: 2995174:OSC50_RS01770
uniprot id: A0A9E8GI79
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

2995174:OSC50 RS06960
gene id: 2995174:OSC50_RS06960
uniprot id: A0A9E8GNQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

2995174:OSC50 RS03970
gene id: 2995174:OSC50_RS03970
uniprot id: A0A9E8GPR1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

2995174:OSC50 RS24670
gene id: 2995174:OSC50_RS24670
uniprot id: A0A9E8GH43
names: Subcellular Location Annotation
messages: Membrane

2995174:OSC50 RS01865
gene id: 2995174:OSC50_RS01865
uniprot id: A0A9E8GM07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

2995174:OSC50 RS25470
gene id: 2995174:OSC50_RS25470
uniprot id: A0A9E8H9C1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
messages: Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
messages: Cytoplasm
messages: Homodimer.

2995174:OSC50 RS20040
gene id: 2995174:OSC50_RS20040
uniprot id: A0A9E8GT49
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

2995174:OSC50 RS25320
gene id: 2995174:OSC50_RS25320
uniprot id: A0A9E8KB18
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

2995174:OSC50 RS05280
gene id: 2995174:OSC50_RS05280
uniprot id: A0A9E8GJS3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

2995174:OSC50 RS00850
gene id: 2995174:OSC50_RS00850
uniprot id: A0A9E8K895
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2995174:OSC50 RS18335
gene id: 2995174:OSC50_RS18335
uniprot id: A0A9E8KCC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2995174:OSC50 RS05210
gene id: 2995174:OSC50_RS05210
uniprot id: A0A9E8GU65
names: Similarity
messages: Belongs to the aspartokinase family.

2995174:OSC50 RS25815
gene id: 2995174:OSC50_RS25815
uniprot id: A0A9E8KHT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell inner membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

2995174:OSC50 RS04520
gene id: 2995174:OSC50_RS04520
uniprot id: A0A9E8H0T5
names: Subcellular Location Annotation
messages: Cytoplasm

2995174:OSC50 RS15700
gene id: 2995174:OSC50_RS15700
uniprot id: A0A9E8H2W3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

2995174:OSC50 RS19885
gene id: 2995174:OSC50_RS19885
uniprot id: A0A9E8H495
names: Similarity
messages: Belongs to the BolA/IbaG family.

2995174:OSC50 RS22300
gene id: 2995174:OSC50_RS22300
uniprot id: A0A9E8GSB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

2995174:OSC50 RS18685
gene id: 2995174:OSC50_RS18685
uniprot id: A0A9E8H4N2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

2995174:OSC50 RS22685
gene id: 2995174:OSC50_RS22685
uniprot id: A0A9E8H6J8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

2995174:OSC50 RS02025
gene id: 2995174:OSC50_RS02025
uniprot id: A0A9E8GM26
names: Caution
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

2995174:OSC50 RS19705
gene id: 2995174:OSC50_RS19705
uniprot id: A0A9E8H1F4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: Homotetramer.
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

2995174:OSC50 RS05515
gene id: 2995174:OSC50_RS05515
uniprot id: A0A9E8GLJ4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

2995174:OSC50 RS07300
gene id: 2995174:OSC50_RS07300
uniprot id: A0A9E8GZV7
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

2995174:OSC50 RS04100
gene id: 2995174:OSC50_RS04100
uniprot id: A0A9E8GPU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

2995174:OSC50 RS01875
gene id: 2995174:OSC50_RS01875
uniprot id: A0A9E8GK75
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

2995174:OSC50 RS08730
gene id: 2995174:OSC50_RS08730
uniprot id: A0A9E8H5E1
names: Function
names: Similarity
messages: Belongs to the PqqA family.
messages: Required for coenzyme pyrroloquinoline quinone (PQQ) biosynthesis. PQQ is probably formed by cross-linking a specific glutamate to a specific tyrosine residue and excising these residues from the peptide.

2995174:OSC50 RS20125
gene id: 2995174:OSC50_RS20125
uniprot id: A0A9E8K4W3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

2995174:OSC50 RS25330
gene id: 2995174:OSC50_RS25330
uniprot id: A0A9E8GT90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

2995174:OSC50 RS22910
gene id: 2995174:OSC50_RS22910
uniprot id: A0A9E8GFX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2995174:OSC50 RS00320
gene id: 2995174:OSC50_RS00320
uniprot id: A0A9E8KAC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.

2995174:OSC50 RS25110
gene id: 2995174:OSC50_RS25110
uniprot id: A0A9E8GH73
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.

2995174:OSC50 RS15900
gene id: 2995174:OSC50_RS15900
uniprot id: A0A9E8H683
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

2995174:OSC50 RS25310
gene id: 2995174:OSC50_RS25310
uniprot id: A0A9E8H0V8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

2995174:OSC50 RS22595
gene id: 2995174:OSC50_RS22595
uniprot id: A0A9E8H3E9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

2995174:OSC50 RS22190
gene id: 2995174:OSC50_RS22190
uniprot id: A0A9E8KFR1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

2995174:OSC50 RS01845
gene id: 2995174:OSC50_RS01845
uniprot id: A0A9E8GI88
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

2995174:OSC50 RS03975
gene id: 2995174:OSC50_RS03975
uniprot id: A0A9E8GZH4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

2995174:OSC50 RS13600
gene id: 2995174:OSC50_RS13600
uniprot id: A0A9E8KH89
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NfuA family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is presumably bound at the interface of two monomers.
messages: Homodimer.
messages: Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.

2995174:OSC50 RS03055
gene id: 2995174:OSC50_RS03055
uniprot id: A0A9E8GI77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DksA family.
messages: Cytoplasm
messages: Interacts directly with the RNA polymerase.
messages: Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression.

2995174:OSC50 RS21040
gene id: 2995174:OSC50_RS21040
uniprot id: A0A9E8GUW6
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

2995174:OSC50 RS01805
gene id: 2995174:OSC50_RS01805
uniprot id: A0A9E8H8F2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

2995174:OSC50 RS19605
gene id: 2995174:OSC50_RS19605
uniprot id: A0A9E8GF88
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

2995174:OSC50 RS17275
gene id: 2995174:OSC50_RS17275
uniprot id: A0A9E8KCP9
names: Function
names: Similarity
messages: An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.
messages: Belongs to the SdhE FAD assembly factor family.

2995174:OSC50 RS22075
gene id: 2995174:OSC50_RS22075
uniprot id: A0A9E8KBC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

2995174:OSC50 RS06200
gene id: 2995174:OSC50_RS06200
uniprot id: A0A9E8GRN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

2995174:OSC50 RS20260
gene id: 2995174:OSC50_RS20260
uniprot id: A0A9E8GUH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2995174:OSC50 RS00330
gene id: 2995174:OSC50_RS00330
uniprot id: A0A9E8K6U8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoH subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.

2995174:OSC50 RS22645
gene id: 2995174:OSC50_RS22645
uniprot id: A0A9E8KFN1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.

2995174:OSC50 RS25285
gene id: 2995174:OSC50_RS25285
uniprot id: A0A9E8GL29
names: Similarity
messages: Belongs to the RutC family.

2995174:OSC50 RS22815
gene id: 2995174:OSC50_RS22815
uniprot id: A0A9E8GSB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

2995174:OSC50 RS20140
gene id: 2995174:OSC50_RS20140
uniprot id: A0A9E8H2L8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

2995174:OSC50 RS03650
gene id: 2995174:OSC50_RS03650
uniprot id: A0A9E8GI39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane

2995174:OSC50 RS05385
gene id: 2995174:OSC50_RS05385
uniprot id: A0A9E8GQY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

2995174:OSC50 RS09430
gene id: 2995174:OSC50_RS09430
uniprot id: A0A9E8H5K9
names: Function
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.

2995174:OSC50 RS09405
gene id: 2995174:OSC50_RS09405
uniprot id: A0A9E8GK66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2995174:OSC50 RS03990
gene id: 2995174:OSC50_RS03990
uniprot id: A0A9E8K6N1
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

2995174:OSC50 RS17225
gene id: 2995174:OSC50_RS17225
uniprot id: A0A9E8KBX9
names: Subcellular Location Annotation
messages: Cytoplasm

2995174:OSC50 RS22790
gene id: 2995174:OSC50_RS22790
uniprot id: A0A9E8KB75
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

2995174:OSC50 RS25370
gene id: 2995174:OSC50_RS25370
uniprot id: A0A9E8GRZ1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

2995174:OSC50 RS01495
gene id: 2995174:OSC50_RS01495
uniprot id: A0A9E8KB21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

2995174:OSC50 RS05215
gene id: 2995174:OSC50_RS05215
uniprot id: A0A9E8GPD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

2995174:OSC50 RS15730
gene id: 2995174:OSC50_RS15730
uniprot id: A0A9E8H8T1
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD.
messages: The heme is bound between the two transmembrane subunits.

2995174:OSC50 RS16975
gene id: 2995174:OSC50_RS16975
uniprot id: A0A9E8H590
names: Similarity
messages: Belongs to the UPF0260 family.

2995174:OSC50 RS02970
gene id: 2995174:OSC50_RS02970
uniprot id: A0A9E8GT74
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

2995174:OSC50 RS03350
gene id: 2995174:OSC50_RS03350
uniprot id: A0A9E8H7V6
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

2995174:OSC50 RS25960
gene id: 2995174:OSC50_RS25960
uniprot id: A0A9E8K5R6
names: Similarity
messages: Belongs to the outer membrane porin (Opr) (TC 1.B.25) family.

2995174:OSC50 RS01750
gene id: 2995174:OSC50_RS01750
uniprot id: A0A9E8K627
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Methylated by PrmB.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

2995174:OSC50 RS17955
gene id: 2995174:OSC50_RS17955
uniprot id: A0A9E8H3E7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsB family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

2995174:OSC50 RS09655
gene id: 2995174:OSC50_RS09655
uniprot id: A0A9E8GKB7
names: Similarity
messages: Belongs to the UPF0434 family.

2995174:OSC50 RS04790
gene id: 2995174:OSC50_RS04790
uniprot id: A0A9E8H785
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2995174:OSC50 RS22215
gene id: 2995174:OSC50_RS22215
uniprot id: A0A9E8H0F1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.

2995174:OSC50 RS01685
gene id: 2995174:OSC50_RS01685
uniprot id: A0A9E8GHQ2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2995174:OSC50 RS16960
gene id: 2995174:OSC50_RS16960
uniprot id: A0A9E8GLC5
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

2995174:OSC50 RS08905
gene id: 2995174:OSC50_RS08905
uniprot id: A0A9E8GSM0
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

2995174:OSC50 RS18625
gene id: 2995174:OSC50_RS18625
uniprot id: A0A9E8K4L3
names: Similarity
messages: Belongs to the glutaredoxin family. Monothiol subfamily.

2995174:OSC50 RS22185
gene id: 2995174:OSC50_RS22185
uniprot id: A0A9E8GMQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

2995174:OSC50 RS07400
gene id: 2995174:OSC50_RS07400
uniprot id: A0A9E8GY36
names: Similarity
messages: Belongs to the UPF0270 family.

2995174:OSC50 RS13690
gene id: 2995174:OSC50_RS13690
uniprot id: A0A9E8H0L5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

2995174:OSC50 RS01810
gene id: 2995174:OSC50_RS01810
uniprot id: A0A9E8K5S8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

2995174:OSC50 RS01280
gene id: 2995174:OSC50_RS01280
uniprot id: A0A9E8GWT2
names: Function
names: Similarity
messages: Belongs to the PqqA family.
messages: Required for coenzyme pyrroloquinoline quinone (PQQ) biosynthesis. PQQ is probably formed by cross-linking a specific glutamate to a specific tyrosine residue and excising these residues from the peptide.

2995174:OSC50 RS01730
gene id: 2995174:OSC50_RS01730
uniprot id: A0A9E8K699
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

2995174:OSC50 RS01395
gene id: 2995174:OSC50_RS01395
uniprot id: A0A9E8K8D0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

2995174:OSC50 RS15640
gene id: 2995174:OSC50_RS15640
uniprot id: A0A9E8GDG2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

2995174:OSC50 RS20075
gene id: 2995174:OSC50_RS20075
uniprot id: A0A9E8GEY8
names: Similarity
messages: Belongs to the UxaA family.

2995174:OSC50 RS24320
gene id: 2995174:OSC50_RS24320
uniprot id: A0A9E8GGI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

2995174:OSC50 RS00350
gene id: 2995174:OSC50_RS00350
uniprot id: A0A9E8GH96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

2995174:OSC50 RS03380
gene id: 2995174:OSC50_RS03380
uniprot id: A0A9E8GUV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

2995174:OSC50 RS09370
gene id: 2995174:OSC50_RS09370
uniprot id: A0A9E8H5I8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2995174:OSC50 RS04620
gene id: 2995174:OSC50_RS04620
uniprot id: A0A9E8K9N2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YciB family.
messages: Cell inner membrane
messages: Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.

2995174:OSC50 RS09465
gene id: 2995174:OSC50_RS09465
uniprot id: A0A9E8GQV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

2995174:OSC50 RS03125
gene id: 2995174:OSC50_RS03125
uniprot id: A0A9E8GZ24
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

2995174:OSC50 RS20535
gene id: 2995174:OSC50_RS20535
uniprot id: A0A9E8H771
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

2995174:OSC50 RS02720
gene id: 2995174:OSC50_RS02720
uniprot id: A0A9E8KHA7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2995174:OSC50 RS24675
gene id: 2995174:OSC50_RS24675
uniprot id: A0A9E8GJ16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

2995174:OSC50 RS03370
gene id: 2995174:OSC50_RS03370
uniprot id: A0A9E8GT22
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

2995174:OSC50 RS19650
gene id: 2995174:OSC50_RS19650
uniprot id: A0A9E8K465
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

2995174:OSC50 RS08110
gene id: 2995174:OSC50_RS08110
uniprot id: A0A9E8GXF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

2995174:OSC50 RS17970
gene id: 2995174:OSC50_RS17970
uniprot id: A0A9E8GVX8
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2995174:OSC50 RS01760
gene id: 2995174:OSC50_RS01760
uniprot id: A0A9E8KER7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

2995174:OSC50 RS09735
gene id: 2995174:OSC50_RS09735
uniprot id: A0A9E8GXE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2995174:OSC50 RS08985
gene id: 2995174:OSC50_RS08985
uniprot id: A0A9E8GK22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

2995174:OSC50 RS08000
gene id: 2995174:OSC50_RS08000
uniprot id: A0A9E8GP67
names: Subcellular Location Annotation
messages: Membrane

2995174:OSC50 RS15695
gene id: 2995174:OSC50_RS15695
uniprot id: A0A9E8GKA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

2995174:OSC50 RS22145
gene id: 2995174:OSC50_RS22145
uniprot id: A0A9E8K593
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

2995174:OSC50 RS19875
gene id: 2995174:OSC50_RS19875
uniprot id: A0A9E8GJ42
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

2995174:OSC50 RS01765
gene id: 2995174:OSC50_RS01765
uniprot id: A0A9E8GPU1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

2995174:OSC50 RS22060
gene id: 2995174:OSC50_RS22060
uniprot id: A0A9E8H6R3
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.

2995174:OSC50 RS01795
gene id: 2995174:OSC50_RS01795
uniprot id: A0A9E8GIF0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

2995174:OSC50 RS02290
gene id: 2995174:OSC50_RS02290
uniprot id: A0A9E8KA59
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

2995174:OSC50 RS06790
gene id: 2995174:OSC50_RS06790
uniprot id: A0A9E8KDW5
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

2995174:OSC50 RS09400
gene id: 2995174:OSC50_RS09400
uniprot id: A0A9E8GMY0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2995174:OSC50 RS17900
gene id: 2995174:OSC50_RS17900
uniprot id: A0A9E8KGH3
names: Subcellular Location Annotation
messages: Cytoplasm

2995174:OSC50 RS07945
gene id: 2995174:OSC50_RS07945
uniprot id: A0A9E8KGC3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

2995174:OSC50 RS22955
gene id: 2995174:OSC50_RS22955
uniprot id: A0A9E8H2F7
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2995174:OSC50 RS19680
gene id: 2995174:OSC50_RS19680
uniprot id: A0A9E8HB89
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

2995174:OSC50 RS18050
gene id: 2995174:OSC50_RS18050
uniprot id: A0A9E8GEA7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2995174:OSC50 RS09365
gene id: 2995174:OSC50_RS09365
uniprot id: A0A9E8GPN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: Composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2995174:OSC50 RS23450
gene id: 2995174:OSC50_RS23450
uniprot id: A0A9E8KI97
names: Cofactor
names: Similarity
messages: Belongs to the RimK family.
messages: Binds 2 magnesium or manganese ions per subunit.

2995174:OSC50 RS01705
gene id: 2995174:OSC50_RS01705
uniprot id: A0A9E8GRR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

2995174:OSC50 RS17875
gene id: 2995174:OSC50_RS17875
uniprot id: A0A9E8KC75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

2995174:OSC50 RS20710
gene id: 2995174:OSC50_RS20710
uniprot id: A0A9E8K7U4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

2995174:OSC50 RS05995
gene id: 2995174:OSC50_RS05995
uniprot id: A0A9E8K6M4
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

2995174:OSC50 RS09410
gene id: 2995174:OSC50_RS09410
uniprot id: A0A9E8GMX1
names: Cofactor
messages: Can also use Mn(2+) ion.

2995174:OSC50 RS03810
gene id: 2995174:OSC50_RS03810
uniprot id: A0A9E8GI76
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

2995174:OSC50 RS25000
gene id: 2995174:OSC50_RS25000
uniprot id: A0A9E8H2R0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

2995174:OSC50 RS01255
gene id: 2995174:OSC50_RS01255
uniprot id: A0A9E8KB32
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

2995174:OSC50 RS01860
gene id: 2995174:OSC50_RS01860
uniprot id: A0A9E8GYB5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

2995174:OSC50 RS01605
gene id: 2995174:OSC50_RS01605
uniprot id: A0A9E8KCV5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HesB/IscA family.
messages: Binds 1 iron-sulfur cluster per subunit.
messages: Homodimer.
messages: Required for insertion of 4Fe-4S clusters for at least IspG.

2995174:OSC50 RS22065
gene id: 2995174:OSC50_RS22065
uniprot id: A0A9E8K4M3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

2995174:OSC50 RS11555
gene id: 2995174:OSC50_RS11555
uniprot id: A0A9E8KDT7
names: Similarity
messages: Belongs to the UDPGP type 2 family.

2995174:OSC50 RS17255
gene id: 2995174:OSC50_RS17255
uniprot id: A0A9E8GW61
names: Similarity
messages: Belongs to the RseA family.

2995174:OSC50 RS01825
gene id: 2995174:OSC50_RS01825
uniprot id: A0A9E8K631
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

2995174:OSC50 RS02835
gene id: 2995174:OSC50_RS02835
uniprot id: A0A9E8H976
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

2995174:OSC50 RS05195
gene id: 2995174:OSC50_RS05195
uniprot id: A0A9E8K9Y4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2995174:OSC50 RS20115
gene id: 2995174:OSC50_RS20115
uniprot id: A0A9E8GFL4
names: Similarity
messages: Belongs to the GST superfamily. HSP26 family.

2995174:OSC50 RS22130
gene id: 2995174:OSC50_RS22130
uniprot id: A0A9E8H0G1
names: Function
names: Similarity
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.

2995174:OSC50 RS17205
gene id: 2995174:OSC50_RS17205
uniprot id: A0A9E8KHM7
names: Similarity
messages: Belongs to the SAICAR synthetase family.

2995174:OSC50 RS05130
gene id: 2995174:OSC50_RS05130
uniprot id: A0A9E8K900
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane

2995174:OSC50 RS01510
gene id: 2995174:OSC50_RS01510
uniprot id: A0A9E8GHF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2995174:OSC50 RS01725
gene id: 2995174:OSC50_RS01725
uniprot id: A0A9E8GK54
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

2995174:OSC50 RS01790
gene id: 2995174:OSC50_RS01790
uniprot id: A0A9E8GLZ7
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

2995174:OSC50 RS02285
gene id: 2995174:OSC50_RS02285
uniprot id: A0A9E8GZU8
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

2995174:OSC50 RS01890
gene id: 2995174:OSC50_RS01890
uniprot id: A0A9E8KA83
names: Function
names: Similarity
messages: Belongs to the bacterioferritin family.
messages: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.

2995174:OSC50 RS09825
gene id: 2995174:OSC50_RS09825
uniprot id: A0A9E8H5F6
names: Similarity
names: Subunit
messages: Belongs to the glutaminase family.
messages: Homotetramer.

2995174:OSC50 RS18060
gene id: 2995174:OSC50_RS18060
uniprot id: A0A9E8GL78
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

2995174:OSC50 RS18040
gene id: 2995174:OSC50_RS18040
uniprot id: A0A9E8K6K6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2995174:OSC50 RS16775
gene id: 2995174:OSC50_RS16775
uniprot id: A0A9E8K6C6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

2995174:OSC50 RS24510
gene id: 2995174:OSC50_RS24510
uniprot id: A0A9E8H2T1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family. TsaC subfamily.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.

2995174:OSC50 RS24695
gene id: 2995174:OSC50_RS24695
uniprot id: A0A9E8KAU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

2995174:OSC50 RS03700
gene id: 2995174:OSC50_RS03700
uniprot id: A0A9E8GUR9
names: Similarity
messages: Belongs to the HesB/IscA family.

2995174:OSC50 RS19025
gene id: 2995174:OSC50_RS19025
uniprot id: A0A9E8KBZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

2995174:OSC50 RS21680
gene id: 2995174:OSC50_RS21680
uniprot id: A0A9E8KB67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

2995174:OSC50 RS01735
gene id: 2995174:OSC50_RS01735
uniprot id: A0A9E8H015
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

2995174:OSC50 RS18610
gene id: 2995174:OSC50_RS18610
uniprot id: A0A9E8GIP2
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

2995174:OSC50 RS09675
gene id: 2995174:OSC50_RS09675
uniprot id: A0A9E8GLE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

2995174:OSC50 RS01740
gene id: 2995174:OSC50_RS01740
uniprot id: A0A9E8KA93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

2995174:OSC50 RS02965
gene id: 2995174:OSC50_RS02965
uniprot id: A0A9E8KAC7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

2995174:OSC50 RS01755
gene id: 2995174:OSC50_RS01755
uniprot id: A0A9E8GZI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

2995174:OSC50 RS04830
gene id: 2995174:OSC50_RS04830
uniprot id: A0A9E8KF10
names: Similarity
messages: Belongs to the KHG/KDPG aldolase family.

2995174:OSC50 RS21705
gene id: 2995174:OSC50_RS21705
uniprot id: A0A9E8GFI2
names: Function
names: Similarity
messages: Belongs to the Dus family. DusB subfamily.
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

2995174:OSC50 RS22080
gene id: 2995174:OSC50_RS22080
uniprot id: A0A9E8H3W2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

2995174:OSC50 RS25260
gene id: 2995174:OSC50_RS25260
uniprot id: A0A9E8GWC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

2995174:OSC50 RS02150
gene id: 2995174:OSC50_RS02150
uniprot id: A0A9E8GTI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0719 family.
messages: Membrane

2995174:OSC50 RS00255
gene id: 2995174:OSC50_RS00255
uniprot id: A0A9E8K2I0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

2995174:OSC50 RS18765
gene id: 2995174:OSC50_RS18765
uniprot id: A0A9E8GF51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LysR transcriptional regulatory family.
messages: Cytoplasm

2995174:OSC50 RS01855
gene id: 2995174:OSC50_RS01855
uniprot id: A0A9E8GRP9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

2995174:OSC50 RS14785
gene id: 2995174:OSC50_RS14785
uniprot id: A0A9E8GD75
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit A family.

2995174:OSC50 RS03130
gene id: 2995174:OSC50_RS03130
uniprot id: A0A9E8GI86
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2995174:OSC50 RS03375
gene id: 2995174:OSC50_RS03375
uniprot id: A0A9E8GYZ7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

2995174:OSC50 RS03555
gene id: 2995174:OSC50_RS03555
uniprot id: A0A9E8GIT8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Membrane

2995174:OSC50 RS18590
gene id: 2995174:OSC50_RS18590
uniprot id: A0A9E8GEW5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

2995174:OSC50 RS15740
gene id: 2995174:OSC50_RS15740
uniprot id: A0A9E8K8M2
names: Similarity
messages: Belongs to the citrate synthase family.