2991496:OJ254 RS11360
gene id: 2991496:OJ254_RS11360
uniprot id: A0A9E8EAA9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

2991496:OJ254 RS11365
gene id: 2991496:OJ254_RS11365
uniprot id: A0A9E8ECC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

2991496:OJ254 RS13890
gene id: 2991496:OJ254_RS13890
uniprot id: A0A9E8EK17
names: Similarity
messages: Belongs to the GroES chaperonin family.

2991496:OJ254 RS15005
gene id: 2991496:OJ254_RS15005
uniprot id: A0A9E8ECA6
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

2991496:OJ254 RS11220
gene id: 2991496:OJ254_RS11220
uniprot id: A0A9E8EBG9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

2991496:OJ254 RS07560
gene id: 2991496:OJ254_RS07560
uniprot id: A0A9E8IZQ8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

2991496:OJ254 RS01430
gene id: 2991496:OJ254_RS01430
uniprot id: A0A9E8E738
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

2991496:OJ254 RS03835
gene id: 2991496:OJ254_RS03835
uniprot id: A0A9E8E763
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

2991496:OJ254 RS04415
gene id: 2991496:OJ254_RS04415
uniprot id: A0A9E8IZ61
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

2991496:OJ254 RS29175
gene id: 2991496:OJ254_RS29175
uniprot id: A0A9E8EEZ4
names: Function
names: Similarity
messages: Belongs to the uricase family.
messages: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.

2991496:OJ254 RS09020
gene id: 2991496:OJ254_RS09020
uniprot id: A0A9E8E8I7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CrgA family.
messages: Cell membrane
messages: Involved in cell division.

2991496:OJ254 RS11130
gene id: 2991496:OJ254_RS11130
uniprot id: A0A9E8EBF8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

2991496:OJ254 RS29180
gene id: 2991496:OJ254_RS29180
uniprot id: A0A9E8EFJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
messages: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
messages: Homotetramer.

2991496:OJ254 RS01470
gene id: 2991496:OJ254_RS01470
uniprot id: A0A9E8E8N0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

2991496:OJ254 RS18955
gene id: 2991496:OJ254_RS18955
uniprot id: A0A9E8EDG2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

2991496:OJ254 RS08870
gene id: 2991496:OJ254_RS08870
uniprot id: A0A9E8IZQ1
names: Similarity
messages: Belongs to the thioredoxin family.

2991496:OJ254 RS11370
gene id: 2991496:OJ254_RS11370
uniprot id: A0A9E8E934
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

2991496:OJ254 RS02720
gene id: 2991496:OJ254_RS02720
uniprot id: A0A9E8J211
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

2991496:OJ254 RS10810
gene id: 2991496:OJ254_RS10810
uniprot id: A0A9E8EB50
names: Subcellular Location Annotation
messages: Cytoplasm

2991496:OJ254 RS25565
gene id: 2991496:OJ254_RS25565
uniprot id: A0A9E8EDK0
names: Subcellular Location Annotation
messages: Cytoplasm

2991496:OJ254 RS13615
gene id: 2991496:OJ254_RS13615
uniprot id: A0A9E8J3N7
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

2991496:OJ254 RS05595
gene id: 2991496:OJ254_RS05595
uniprot id: A0A9E8E896
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

2991496:OJ254 RS22070
gene id: 2991496:OJ254_RS22070
uniprot id: A0A9E8EDF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the gas vesicle GvpA family.
messages: Gas vesicle shell
messages: Gas vesicles are hollow, gas filled proteinaceous nanostructures found in some microorganisms. During planktonic growth they allow positioning of the organism at a favorable depth for light or nutrient acquisition. GvpA forms the protein shell.
messages: The gas vesicle shell is 2 nm thick and consists of a single layer of this protein. It forms helical ribs nearly perpendicular to the long axis of the vesicle.

2991496:OJ254 RS20220
gene id: 2991496:OJ254_RS20220
uniprot id: A0A9E8EDX3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic ubiquitin-like protein family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.
messages: Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half. There is one Pup binding site per ARC hexamer ring.
messages: The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome.

2991496:OJ254 RS01870
gene id: 2991496:OJ254_RS01870
uniprot id: A0A9E8E8R8
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

2991496:OJ254 RS11175
gene id: 2991496:OJ254_RS11175
uniprot id: A0A9E8E945
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

2991496:OJ254 RS20460
gene id: 2991496:OJ254_RS20460
uniprot id: A0A9E8EBU5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

2991496:OJ254 RS15110
gene id: 2991496:OJ254_RS15110
uniprot id: A0A9E8ED10
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

2991496:OJ254 RS03285
gene id: 2991496:OJ254_RS03285
uniprot id: A0A9E8E6X7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

2991496:OJ254 RS24835
gene id: 2991496:OJ254_RS24835
uniprot id: A0A9E8J2H3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2991496:OJ254 RS25645
gene id: 2991496:OJ254_RS25645
uniprot id: A0A9E8J2H5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase-binding protein RbpA family.
messages: Bind 1 Zn(2+) per subunit.
messages: Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
messages: Forms a complex with the RNAP catalytic core and with free principal sigma factors.

2991496:OJ254 RS00495
gene id: 2991496:OJ254_RS00495
uniprot id: A0A9E8IYP9
names: Subcellular Location Annotation
messages: Cytoplasm

2991496:OJ254 RS20150
gene id: 2991496:OJ254_RS20150
uniprot id: A0A9E8J1K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

2991496:OJ254 RS05980
gene id: 2991496:OJ254_RS05980
uniprot id: A0A9E8E7P8
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

2991496:OJ254 RS07980
gene id: 2991496:OJ254_RS07980
uniprot id: A0A9E8EAD3
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

2991496:OJ254 RS10925
gene id: 2991496:OJ254_RS10925
uniprot id: A0A9E8EB57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2991496:OJ254 RS10090
gene id: 2991496:OJ254_RS10090
uniprot id: A0A9E8IZV7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2991496:OJ254 RS11250
gene id: 2991496:OJ254_RS11250
uniprot id: A0A9E8E901
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

2991496:OJ254 RS01630
gene id: 2991496:OJ254_RS01630
uniprot id: A0A9E8J114
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

2991496:OJ254 RS11275
gene id: 2991496:OJ254_RS11275
uniprot id: A0A9E8EAA0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

2991496:OJ254 RS07415
gene id: 2991496:OJ254_RS07415
uniprot id: A0A9E8J2R5
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

2991496:OJ254 RS20250
gene id: 2991496:OJ254_RS20250
uniprot id: A0A9E8J1L1
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.
messages: Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
messages: The reaction mechanism probably proceeds via the activation of Pup by phosphorylation of its C-terminal glutamate, which is then subject to nucleophilic attack by the substrate lysine, resulting in an isopeptide bond and the release of phosphate as a good leaving group.

2991496:OJ254 RS11255
gene id: 2991496:OJ254_RS11255
uniprot id: A0A9E8E954
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

2991496:OJ254 RS11295
gene id: 2991496:OJ254_RS11295
uniprot id: A0A9E8EB94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

2991496:OJ254 RS17710
gene id: 2991496:OJ254_RS17710
uniprot id: A0A9E8J3C3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

2991496:OJ254 RS13210
gene id: 2991496:OJ254_RS13210
uniprot id: A0A9E8EAB1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
messages: Belongs to the WhiB family.
messages: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
messages: Cytoplasm
messages: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
messages: Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

2991496:OJ254 RS11570
gene id: 2991496:OJ254_RS11570
uniprot id: A0A9E8EBC5
names: Similarity
messages: Belongs to the IMPDH/GMPR family.

2991496:OJ254 RS11300
gene id: 2991496:OJ254_RS11300
uniprot id: A0A9E8EBH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

2991496:OJ254 RS13355
gene id: 2991496:OJ254_RS13355
uniprot id: A0A9E8E9N9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

2991496:OJ254 RS06850
gene id: 2991496:OJ254_RS06850
uniprot id: A0A9E8J2N7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DisA family.
messages: Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.
messages: Homooctamer.
messages: Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, DisA pauses at the lesion site. This triggers a cellular response that culminates in a temporary block in sporulation initiation.

2991496:OJ254 RS20205
gene id: 2991496:OJ254_RS20205
uniprot id: A0A9E8EEJ7
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

2991496:OJ254 RS11960
gene id: 2991496:OJ254_RS11960
uniprot id: A0A9E8J3E7
names: Subcellular Location Annotation
messages: Cytoplasm

2991496:OJ254 RS20785
gene id: 2991496:OJ254_RS20785
uniprot id: A0A9E8EER1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SsgA family.
messages: Cell septum

2991496:OJ254 RS11215
gene id: 2991496:OJ254_RS11215
uniprot id: A0A9E8EB86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

2991496:OJ254 RS11265
gene id: 2991496:OJ254_RS11265
uniprot id: A0A9E8J3F1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

2991496:OJ254 RS11290
gene id: 2991496:OJ254_RS11290
uniprot id: A0A9E8EBX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

2991496:OJ254 RS10110
gene id: 2991496:OJ254_RS10110
uniprot id: A0A9E8E8Q0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2991496:OJ254 RS01150
gene id: 2991496:OJ254_RS01150
uniprot id: A0A9E8E9J2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

2991496:OJ254 RS02770
gene id: 2991496:OJ254_RS02770
uniprot id: A0A9E8E7G8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

2991496:OJ254 RS15380
gene id: 2991496:OJ254_RS15380
uniprot id: A0A9E8EDI2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

2991496:OJ254 RS08785
gene id: 2991496:OJ254_RS08785
uniprot id: A0A9E8J224
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

2991496:OJ254 RS02845
gene id: 2991496:OJ254_RS02845
uniprot id: A0A9E8EB91
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

2991496:OJ254 RS20465
gene id: 2991496:OJ254_RS20465
uniprot id: A0A9E8EGE8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

2991496:OJ254 RS28000
gene id: 2991496:OJ254_RS28000
uniprot id: A0A9E8J297
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

2991496:OJ254 RS07690
gene id: 2991496:OJ254_RS07690
uniprot id: A0A9E8E9B9
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

2991496:OJ254 RS13045
gene id: 2991496:OJ254_RS13045
uniprot id: A0A9E8J0J6
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

2991496:OJ254 RS02800
gene id: 2991496:OJ254_RS02800
uniprot id: A0A9E8E995
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

2991496:OJ254 RS11165
gene id: 2991496:OJ254_RS11165
uniprot id: A0A9E8J086
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

2991496:OJ254 RS03130
gene id: 2991496:OJ254_RS03130
uniprot id: A0A9E8IZ39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2991496:OJ254 RS08775
gene id: 2991496:OJ254_RS08775
uniprot id: A0A9E8IZP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

2991496:OJ254 RS08905
gene id: 2991496:OJ254_RS08905
uniprot id: A0A9E8E8H6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

2991496:OJ254 RS17355
gene id: 2991496:OJ254_RS17355
uniprot id: A0A9E8J164
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with subunits I, II and III to form cytochrome c oxidase.
messages: Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
messages: Cell membrane
messages: Membrane
messages: Part of cytochrome c oxidase, its function is unknown.

2991496:OJ254 RS08915
gene id: 2991496:OJ254_RS08915
uniprot id: A0A9E8ECX2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

2991496:OJ254 RS16090
gene id: 2991496:OJ254_RS16090
uniprot id: A0A9E8EBQ2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

2991496:OJ254 RS07065
gene id: 2991496:OJ254_RS07065
uniprot id: A0A9E8EA62
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

2991496:OJ254 RS07095
gene id: 2991496:OJ254_RS07095
uniprot id: A0A9E8J045
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

2991496:OJ254 RS22590
gene id: 2991496:OJ254_RS22590
uniprot id: A0A9E8EH62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sbp family.
messages: Cell membrane

2991496:OJ254 RS05515
gene id: 2991496:OJ254_RS05515
uniprot id: A0A9E8J2G4
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

2991496:OJ254 RS21375
gene id: 2991496:OJ254_RS21375
uniprot id: A0A9E8EGR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

2991496:OJ254 RS01115
gene id: 2991496:OJ254_RS01115
uniprot id: A0A9E8E6B0
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

2991496:OJ254 RS01300
gene id: 2991496:OJ254_RS01300
uniprot id: A0A9E8J0Z9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

2991496:OJ254 RS07040
gene id: 2991496:OJ254_RS07040
uniprot id: A0A9E8EB64
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

2991496:OJ254 RS11235
gene id: 2991496:OJ254_RS11235
uniprot id: A0A9E8J0L4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

2991496:OJ254 RS17715
gene id: 2991496:OJ254_RS17715
uniprot id: A0A9E8J184
names: Similarity
messages: Belongs to the YggT family.

2991496:OJ254 RS24935
gene id: 2991496:OJ254_RS24935
uniprot id: A0A9E8J2H8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

2991496:OJ254 RS00840
gene id: 2991496:OJ254_RS00840
uniprot id: A0A9E8E8Y8
names: Similarity
messages: Belongs to the WXG100 family.

2991496:OJ254 RS06875
gene id: 2991496:OJ254_RS06875
uniprot id: A0A9E8EH66
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

2991496:OJ254 RS18415
gene id: 2991496:OJ254_RS18415
uniprot id: A0A9E8J0Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

2991496:OJ254 RS30345
gene id: 2991496:OJ254_RS30345
uniprot id: A0A9E8EJJ5
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

2991496:OJ254 RS11380
gene id: 2991496:OJ254_RS11380
uniprot id: A0A9E8EBA5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

2991496:OJ254 RS28120
gene id: 2991496:OJ254_RS28120
uniprot id: A0A9E8EG97
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
messages: Cell membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.

2991496:OJ254 RS11330
gene id: 2991496:OJ254_RS11330
uniprot id: A0A9E8J096
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

2991496:OJ254 RS01760
gene id: 2991496:OJ254_RS01760
uniprot id: A0A9E8E6I4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

2991496:OJ254 RS06955
gene id: 2991496:OJ254_RS06955
uniprot id: A0A9E8J2P2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2991496:OJ254 RS18395
gene id: 2991496:OJ254_RS18395
uniprot id: A0A9E8EE04
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

2991496:OJ254 RS11535
gene id: 2991496:OJ254_RS11535
uniprot id: A0A9E8E9U9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

2991496:OJ254 RS11285
gene id: 2991496:OJ254_RS11285
uniprot id: A0A9E8E921
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

2991496:OJ254 RS00735
gene id: 2991496:OJ254_RS00735
uniprot id: A0A9E8EAM2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

2991496:OJ254 RS11280
gene id: 2991496:OJ254_RS11280
uniprot id: A0A9E8ECB8
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

2991496:OJ254 RS11310
gene id: 2991496:OJ254_RS11310
uniprot id: A0A9E8J3B0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

2991496:OJ254 RS00075
gene id: 2991496:OJ254_RS00075
uniprot id: A0A9E8E8A8
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

2991496:OJ254 RS01445
gene id: 2991496:OJ254_RS01445
uniprot id: A0A9E8E9M0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

2991496:OJ254 RS12680
gene id: 2991496:OJ254_RS12680
uniprot id: A0A9E8EA58
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

2991496:OJ254 RS11305
gene id: 2991496:OJ254_RS11305
uniprot id: A0A9E8EER3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

2991496:OJ254 RS11355
gene id: 2991496:OJ254_RS11355
uniprot id: A0A9E8E9S9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

2991496:OJ254 RS11270
gene id: 2991496:OJ254_RS11270
uniprot id: A0A9E8E9R9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

2991496:OJ254 RS05900
gene id: 2991496:OJ254_RS05900
uniprot id: A0A9E8E8U2
names: Subcellular Location Annotation
messages: Cytoplasm

2991496:OJ254 RS11240
gene id: 2991496:OJ254_RS11240
uniprot id: A0A9E8J2D6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

2991496:OJ254 RS11325
gene id: 2991496:OJ254_RS11325
uniprot id: A0A9E8J2E1
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

2991496:OJ254 RS15170
gene id: 2991496:OJ254_RS15170
uniprot id: A0A9E8EAU7
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

2991496:OJ254 RS15050
gene id: 2991496:OJ254_RS15050
uniprot id: A0A9E8EGB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

2991496:OJ254 RS07680
gene id: 2991496:OJ254_RS07680
uniprot id: A0A9E8ECM1
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.

2991496:OJ254 RS21105
gene id: 2991496:OJ254_RS21105
uniprot id: A0A9E8J3V4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.