2781774:ISP08 RS06045
gene id: 2781774:ISP08_RS06045
uniprot id: A0A7T1B201
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

2781774:ISP08 RS11455
gene id: 2781774:ISP08_RS11455
uniprot id: A0A7T1AZI6
names: Similarity
messages: Belongs to the RutC family.

2781774:ISP08 RS07005
gene id: 2781774:ISP08_RS07005
uniprot id: A0A7T1F8I4
names: Similarity
messages: Belongs to the UPF0403 family.

2781774:ISP08 RS11240
gene id: 2781774:ISP08_RS11240
uniprot id: A0A7T1AZD3
names: Caution
names: Function
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.
messages: Catalyzes the specific phosphorylation of arginine residues in proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2781774:ISP08 RS03505
gene id: 2781774:ISP08_RS03505
uniprot id: A0A7T1FAA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

2781774:ISP08 RS10550
gene id: 2781774:ISP08_RS10550
uniprot id: A0A7T1AZ45
names: Similarity
messages: Belongs to the DtxR/MntR family.

2781774:ISP08 RS12680
gene id: 2781774:ISP08_RS12680
uniprot id: A0A7T1F9M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

2781774:ISP08 RS03965
gene id: 2781774:ISP08_RS03965
uniprot id: A0A7T1FA31
names: Similarity
messages: Belongs to the peptidase M20A family.

2781774:ISP08 RS03155
gene id: 2781774:ISP08_RS03155
uniprot id: A0A7T1B0Z9
names: Subcellular Location Annotation
messages: Membrane

2781774:ISP08 RS10090
gene id: 2781774:ISP08_RS10090
uniprot id: A0A7T1AYZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

2781774:ISP08 RS12470
gene id: 2781774:ISP08_RS12470
uniprot id: A0A7T1AZR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

2781774:ISP08 RS06460
gene id: 2781774:ISP08_RS06460
uniprot id: A0A7T1AXP9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

2781774:ISP08 RS02330
gene id: 2781774:ISP08_RS02330
uniprot id: A0A7T1B0N7
names: Caution
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. TarI subfamily.
messages: Catalyzes the transfer of the cytidylyl group of CTP to D-ribitol 5-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2781774:ISP08 RS03545
gene id: 2781774:ISP08_RS03545
uniprot id: A0A7T1FAJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

2781774:ISP08 RS05695
gene id: 2781774:ISP08_RS05695
uniprot id: A0A7T1B1U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

2781774:ISP08 RS11480
gene id: 2781774:ISP08_RS11480
uniprot id: A0A7T1F9E9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease M5 family.
messages: Cytoplasm
messages: Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step.

2781774:ISP08 RS09140
gene id: 2781774:ISP08_RS09140
uniprot id: A0A7T1AYM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily.
messages: Catalyzes the interconversion of ornithine to glutamate semialdehyde.
messages: Cytoplasm

2781774:ISP08 RS06445
gene id: 2781774:ISP08_RS06445
uniprot id: A0A7T1AXN8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

2781774:ISP08 RS04075
gene id: 2781774:ISP08_RS04075
uniprot id: A0A7T1B1M0
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
messages: Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi.

2781774:ISP08 RS07850
gene id: 2781774:ISP08_RS07850
uniprot id: A0A7T1AY59
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

2781774:ISP08 RS11175
gene id: 2781774:ISP08_RS11175
uniprot id: A0A7T1AZC7
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

2781774:ISP08 RS07495
gene id: 2781774:ISP08_RS07495
uniprot id: A0A7T1AY62
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

2781774:ISP08 RS06035
gene id: 2781774:ISP08_RS06035
uniprot id: A0A7T1B1Z7
names: Similarity
messages: Belongs to the UPF0735 family.

2781774:ISP08 RS02655
gene id: 2781774:ISP08_RS02655
uniprot id: A0A7T1B0X3
names: Similarity
messages: Belongs to the ABC transporter superfamily.

2781774:ISP08 RS06085
gene id: 2781774:ISP08_RS06085
uniprot id: A0A7T1B204
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

2781774:ISP08 RS08600
gene id: 2781774:ISP08_RS08600
uniprot id: A0A7T1F8P5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.

2781774:ISP08 RS05380
gene id: 2781774:ISP08_RS05380
uniprot id: A0A7T1FAR9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

2781774:ISP08 RS11235
gene id: 2781774:ISP08_RS11235
uniprot id: A0A7T1AZQ8
names: Similarity
messages: Belongs to the ClpA/ClpB family. ClpC subfamily.

2781774:ISP08 RS11225
gene id: 2781774:ISP08_RS11225
uniprot id: A0A7T1AZC0
names: Similarity
messages: Belongs to the ycf81 family.

2781774:ISP08 RS07755
gene id: 2781774:ISP08_RS07755
uniprot id: A0A7T1AY37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

2781774:ISP08 RS07420
gene id: 2781774:ISP08_RS07420
uniprot id: A0A7T1AY08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0154 family.
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS03535
gene id: 2781774:ISP08_RS03535
uniprot id: A0A7T1B155
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

2781774:ISP08 RS09050
gene id: 2781774:ISP08_RS09050
uniprot id: A0A7T1F900
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

2781774:ISP08 RS07930
gene id: 2781774:ISP08_RS07930
uniprot id: A0A7T1AY61
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

2781774:ISP08 RS03910
gene id: 2781774:ISP08_RS03910
uniprot id: A0A7T1B1B7
names: Cofactor
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.

2781774:ISP08 RS08780
gene id: 2781774:ISP08_RS08780
uniprot id: A0A7T1AYW9
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2781774:ISP08 RS05880
gene id: 2781774:ISP08_RS05880
uniprot id: A0A7T1FAM4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

2781774:ISP08 RS03655
gene id: 2781774:ISP08_RS03655
uniprot id: A0A7T1FAB2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

2781774:ISP08 RS08705
gene id: 2781774:ISP08_RS08705
uniprot id: A0A7T1AYF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Catalyzes quinol oxidation with the concomitant reduction of oxygen to water. Subunit II transfers the electrons from a quinol to the binuclear center of the catalytic subunit I.
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS08230
gene id: 2781774:ISP08_RS08230
uniprot id: A0A7T1F8V3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

2781774:ISP08 RS06595
gene id: 2781774:ISP08_RS06595
uniprot id: A0A7T1F8U9
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

2781774:ISP08 RS11260
gene id: 2781774:ISP08_RS11260
uniprot id: A0A7T1AZD4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

2781774:ISP08 RS06915
gene id: 2781774:ISP08_RS06915
uniprot id: A0A7T1AXT5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

2781774:ISP08 RS08975
gene id: 2781774:ISP08_RS08975
uniprot id: A0A7T1AYP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein required for efficient degradation of Spx by ClpXP under non-stress conditions. Interaction with Spx stabilizes Spx and exposes the C-terminus of Spx for recognition and proteolysis by ClpXP.
messages: Belongs to the SpxH family.
messages: Cytoplasm
messages: Interacts with Spx.

2781774:ISP08 RS11125
gene id: 2781774:ISP08_RS11125
uniprot id: A0A7T1F948
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

2781774:ISP08 RS01135
gene id: 2781774:ISP08_RS01135
uniprot id: A0A7T1B0E6
names: Similarity
messages: Belongs to the MQO family.

2781774:ISP08 RS06675
gene id: 2781774:ISP08_RS06675
uniprot id: A0A7T1AXQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

2781774:ISP08 RS11265
gene id: 2781774:ISP08_RS11265
uniprot id: A0A7T1AZG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.

2781774:ISP08 RS00050
gene id: 2781774:ISP08_RS00050
uniprot id: A0A7T1AZW1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2781774:ISP08 RS11810
gene id: 2781774:ISP08_RS11810
uniprot id: A0A7T1AZM7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

2781774:ISP08 RS07830
gene id: 2781774:ISP08_RS07830
uniprot id: A0A7T1AY49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

2781774:ISP08 RS10600
gene id: 2781774:ISP08_RS10600
uniprot id: A0A7T1F996
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit B family.
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS00725
gene id: 2781774:ISP08_RS00725
uniprot id: A0A7T1F9T3
names: Similarity
messages: Belongs to the alpha-acetolactate decarboxylase family.

2781774:ISP08 RS06095
gene id: 2781774:ISP08_RS06095
uniprot id: A0A7T1B2A4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

2781774:ISP08 RS06440
gene id: 2781774:ISP08_RS06440
uniprot id: A0A7T1F8T9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. CshB subfamily.
messages: Cytoplasm
messages: Probable DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures.

2781774:ISP08 RS09345
gene id: 2781774:ISP08_RS09345
uniprot id: A0A7T1AYP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

2781774:ISP08 RS03775
gene id: 2781774:ISP08_RS03775
uniprot id: A0A7T1FAL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

2781774:ISP08 RS08565
gene id: 2781774:ISP08_RS08565
uniprot id: A0A7T1AYF3
names: Function
names: Similarity
names: Subunit
messages: A non-essential component of RNA polymerase (RNAP).
messages: Belongs to the RNA polymerase subunit epsilon family.
messages: RNAP is composed of a core of 2 alpha, a beta and a beta' subunit. The core is associated with a delta subunit, and at least one of epsilon or omega. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

2781774:ISP08 RS06730
gene id: 2781774:ISP08_RS06730
uniprot id: A0A7T1AXR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

2781774:ISP08 RS10645
gene id: 2781774:ISP08_RS10645
uniprot id: A0A7T1F9K8
names: Subcellular Location Annotation
messages: Cell membrane

2781774:ISP08 RS02160
gene id: 2781774:ISP08_RS02160
uniprot id: A0A7T1B0K5
names: Function
names: Subcellular Location Annotation
messages: Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-exporting P-type ATPase A (CopA).
messages: Cytoplasm

2781774:ISP08 RS03590
gene id: 2781774:ISP08_RS03590
uniprot id: A0A7T1FAK1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

2781774:ISP08 RS10580
gene id: 2781774:ISP08_RS10580
uniprot id: A0A7T1AZ55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS05065
gene id: 2781774:ISP08_RS05065
uniprot id: A0A7T1FAI5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

2781774:ISP08 RS03520
gene id: 2781774:ISP08_RS03520
uniprot id: A0A7T1B169
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

2781774:ISP08 RS10425
gene id: 2781774:ISP08_RS10425
uniprot id: A0A7T1AZ66
names: Similarity
messages: Belongs to the UPF0111 family.

2781774:ISP08 RS05755
gene id: 2781774:ISP08_RS05755
uniprot id: A0A7T1B1W6
names: Similarity
messages: Belongs to the universal stress protein A family.

2781774:ISP08 RS03940
gene id: 2781774:ISP08_RS03940
uniprot id: A0A7T1FAM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

2781774:ISP08 RS04720
gene id: 2781774:ISP08_RS04720
uniprot id: A0A7T1B1I5
names: Subcellular Location Annotation
messages: Cell membrane

2781774:ISP08 RS08190
gene id: 2781774:ISP08_RS08190
uniprot id: A0A7T1F8N5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

2781774:ISP08 RS10985
gene id: 2781774:ISP08_RS10985
uniprot id: A0A7T1AZA0
names: Subcellular Location Annotation
messages: Membrane

2781774:ISP08 RS07355
gene id: 2781774:ISP08_RS07355
uniprot id: A0A7T1F8P7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

2781774:ISP08 RS06065
gene id: 2781774:ISP08_RS06065
uniprot id: A0A7T1FAG4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

2781774:ISP08 RS06305
gene id: 2781774:ISP08_RS06305
uniprot id: A0A7T1F8G5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

2781774:ISP08 RS05105
gene id: 2781774:ISP08_RS05105
uniprot id: A0A7T1FAQ8
names: Similarity
messages: Belongs to the UPF0342 family.

2781774:ISP08 RS11220
gene id: 2781774:ISP08_RS11220
uniprot id: A0A7T1AZH0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

2781774:ISP08 RS02535
gene id: 2781774:ISP08_RS02535
uniprot id: A0A7T1F9T5
names: Similarity
messages: Belongs to the FGGY kinase family.

2781774:ISP08 RS03935
gene id: 2781774:ISP08_RS03935
uniprot id: A0A7T1B1D1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
messages: Homohexamer; trimer of homodimers.

2781774:ISP08 RS00380
gene id: 2781774:ISP08_RS00380
uniprot id: A0A7T1FA05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family. Thioredoxin-coupled ArsC subfamily.
messages: Catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)].
messages: Cytoplasm

2781774:ISP08 RS11510
gene id: 2781774:ISP08_RS11510
uniprot id: A0A7T1AZE4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YabA family.
messages: Interacts with both DnaA and DnaN, acting as a bridge between these two proteins.
messages: Involved in initiation control of chromosome replication.

2781774:ISP08 RS00190
gene id: 2781774:ISP08_RS00190
uniprot id: A0A7T1AZX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS06830
gene id: 2781774:ISP08_RS06830
uniprot id: A0A7T1AXS7
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

2781774:ISP08 RS10530
gene id: 2781774:ISP08_RS10530
uniprot id: A0A7T1AZ68
names: Similarity
messages: Belongs to the ABC transporter superfamily.

2781774:ISP08 RS06100
gene id: 2781774:ISP08_RS06100
uniprot id: A0A7T1B215
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2781774:ISP08 RS06940
gene id: 2781774:ISP08_RS06940
uniprot id: A0A7T1AXY2
names: Similarity
messages: Belongs to the UPF0398 family.

2781774:ISP08 RS08005
gene id: 2781774:ISP08_RS08005
uniprot id: A0A7T1AY82
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

2781774:ISP08 RS07365
gene id: 2781774:ISP08_RS07365
uniprot id: A0A7T1AXZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

2781774:ISP08 RS06150
gene id: 2781774:ISP08_RS06150
uniprot id: A0A7T1FAU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm

2781774:ISP08 RS03750
gene id: 2781774:ISP08_RS03750
uniprot id: A0A7T1B192
names: Similarity
messages: Belongs to the UDPGP type 1 family.

2781774:ISP08 RS10125
gene id: 2781774:ISP08_RS10125
uniprot id: A0A7T1AZ06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS04140
gene id: 2781774:ISP08_RS04140
uniprot id: A0A7T1B1B1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

2781774:ISP08 RS06015
gene id: 2781774:ISP08_RS06015
uniprot id: A0A7T1B1Y4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

2781774:ISP08 RS06330
gene id: 2781774:ISP08_RS06330
uniprot id: A0A7T1AXM7
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

2781774:ISP08 RS11255
gene id: 2781774:ISP08_RS11255
uniprot id: A0A7T1F9Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

2781774:ISP08 RS03765
gene id: 2781774:ISP08_RS03765
uniprot id: A0A7T1B183
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multidrug resistance efflux pump SepA family.
messages: Cell membrane
messages: Involved in multidrug efflux.

2781774:ISP08 RS03295
gene id: 2781774:ISP08_RS03295
uniprot id: A0A7T1B125
names: Subcellular Location Annotation
messages: Membrane

2781774:ISP08 RS02140
gene id: 2781774:ISP08_RS02140
uniprot id: A0A7T1FAA9
names: Subcellular Location Annotation
messages: Membrane

2781774:ISP08 RS08360
gene id: 2781774:ISP08_RS08360
uniprot id: A0A7T1F8N1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

2781774:ISP08 RS03950
gene id: 2781774:ISP08_RS03950
uniprot id: A0A7T1B1A4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

2781774:ISP08 RS04465
gene id: 2781774:ISP08_RS04465
uniprot id: A0A7T1FAN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

2781774:ISP08 RS03620
gene id: 2781774:ISP08_RS03620
uniprot id: A0A7T1FAK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

2781774:ISP08 RS05355
gene id: 2781774:ISP08_RS05355
uniprot id: A0A7T1B1S0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.

2781774:ISP08 RS03580
gene id: 2781774:ISP08_RS03580
uniprot id: A0A7T1FAA7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

2781774:ISP08 RS10830
gene id: 2781774:ISP08_RS10830
uniprot id: A0A7T1AZ80
names: Similarity
messages: Belongs to the ThiD family.

2781774:ISP08 RS06765
gene id: 2781774:ISP08_RS06765
uniprot id: A0A7T1AXT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family.
messages: Cell membrane
messages: Membrane
messages: Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex.

2781774:ISP08 RS09880
gene id: 2781774:ISP08_RS09880
uniprot id: A0A7T1F8X1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

2781774:ISP08 RS11610
gene id: 2781774:ISP08_RS11610
uniprot id: A0A7T1AZG7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

2781774:ISP08 RS08970
gene id: 2781774:ISP08_RS08970
uniprot id: A0A7T1F8Z4
names: Similarity
messages: Belongs to the truncated hemoglobin family. Group II subfamily.

2781774:ISP08 RS03605
gene id: 2781774:ISP08_RS03605
uniprot id: A0A7T1B162
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

2781774:ISP08 RS04820
gene id: 2781774:ISP08_RS04820
uniprot id: A0A7T1B1J8
names: Similarity
messages: Belongs to the UPF0421 family.

2781774:ISP08 RS00010
gene id: 2781774:ISP08_RS00010
uniprot id: A0A7T1AZV8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA which binds and tethers DNA polymerases and other proteins to the DNA. The DNA replisome complex has a single clamp-loading complex (3 tau and 1 each of delta, delta', psi and chi subunits) which binds 3 Pol III cores (1 core on the leading strand and 2 on the lagging strand) each with a beta sliding clamp dimer. Additional proteins in the replisome are other copies of gamma, psi and chi, Ssb, DNA helicase and RNA primase.

2781774:ISP08 RS06770
gene id: 2781774:ISP08_RS06770
uniprot id: A0A7T1F8H9
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

2781774:ISP08 RS03115
gene id: 2781774:ISP08_RS03115
uniprot id: A0A7T1B1A2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

2781774:ISP08 RS04840
gene id: 2781774:ISP08_RS04840
uniprot id: A0A7T1B1N3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

2781774:ISP08 RS04040
gene id: 2781774:ISP08_RS04040
uniprot id: A0A7T1B1B6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

2781774:ISP08 RS03350
gene id: 2781774:ISP08_RS03350
uniprot id: A0A7T1B124
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

2781774:ISP08 RS10790
gene id: 2781774:ISP08_RS10790
uniprot id: A0A7T1AZ74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

2781774:ISP08 RS08720
gene id: 2781774:ISP08_RS08720
uniprot id: A0A7T1F9A5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase bacterial subunit 4 family.
messages: Catalyzes quinol oxidation with the concomitant reduction of oxygen to water.
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS10725
gene id: 2781774:ISP08_RS10725
uniprot id: A0A7T1F920
names: Similarity
messages: Belongs to the UPF0741 family.

2781774:ISP08 RS03890
gene id: 2781774:ISP08_RS03890
uniprot id: A0A7T1FA19
names: Subcellular Location Annotation
messages: Membrane

2781774:ISP08 RS06025
gene id: 2781774:ISP08_RS06025
uniprot id: A0A7T1B1Z8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

2781774:ISP08 RS03770
gene id: 2781774:ISP08_RS03770
uniprot id: A0A7T1FA14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. EmrB family.
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS06470
gene id: 2781774:ISP08_RS06470
uniprot id: A0A7T1F8S3
names: Similarity
messages: Belongs to the transpeptidase family.

2781774:ISP08 RS00125
gene id: 2781774:ISP08_RS00125
uniprot id: A0A7T1F9Z0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS11180
gene id: 2781774:ISP08_RS11180
uniprot id: A0A7T1AZE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

2781774:ISP08 RS04610
gene id: 2781774:ISP08_RS04610
uniprot id: A0A7T1B1K4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.
messages: Homodimer and homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

2781774:ISP08 RS11385
gene id: 2781774:ISP08_RS11385
uniprot id: A0A7T1AZE7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

2781774:ISP08 RS04110
gene id: 2781774:ISP08_RS04110
uniprot id: A0A7T1B1C7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

2781774:ISP08 RS11555
gene id: 2781774:ISP08_RS11555
uniprot id: A0A7T1F963
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

2781774:ISP08 RS11205
gene id: 2781774:ISP08_RS11205
uniprot id: A0A7T1B295
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MrnC RNase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.

2781774:ISP08 RS07740
gene id: 2781774:ISP08_RS07740
uniprot id: A0A7T1AY48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

2781774:ISP08 RS11430
gene id: 2781774:ISP08_RS11430
uniprot id: A0A7T1AZD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

2781774:ISP08 RS10835
gene id: 2781774:ISP08_RS10835
uniprot id: A0A7T1AZ77
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

2781774:ISP08 RS09175
gene id: 2781774:ISP08_RS09175
uniprot id: A0A7T1F8S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit C family.
messages: Membrane

2781774:ISP08 RS08015
gene id: 2781774:ISP08_RS08015
uniprot id: A0A7T1AY69
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

2781774:ISP08 RS01505
gene id: 2781774:ISP08_RS01505
uniprot id: A0A7T1F9L9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

2781774:ISP08 RS05750
gene id: 2781774:ISP08_RS05750
uniprot id: A0A7T1B1U4
names: Similarity
messages: Belongs to the UPF0173 family.

2781774:ISP08 RS06310
gene id: 2781774:ISP08_RS06310
uniprot id: A0A7T1F8R3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

2781774:ISP08 RS03165
gene id: 2781774:ISP08_RS03165
uniprot id: A0A7T1FAH0
names: Subcellular Location Annotation
messages: Membrane

2781774:ISP08 RS07910
gene id: 2781774:ISP08_RS07910
uniprot id: A0A7T1F8S9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

2781774:ISP08 RS03595
gene id: 2781774:ISP08_RS03595
uniprot id: A0A7T1B178
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

2781774:ISP08 RS08995
gene id: 2781774:ISP08_RS08995
uniprot id: A0A7T1AYJ2
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MecA family.
messages: Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.
messages: Homodimer.
messages: The N-terminal domain probably binds unfolded/aggregated proteins; the C-terminal domain interacts with ClpC.

2781774:ISP08 RS07925
gene id: 2781774:ISP08_RS07925
uniprot id: A0A7T1AY80
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

2781774:ISP08 RS07145
gene id: 2781774:ISP08_RS07145
uniprot id: A0A7T1AXX1
names: Subcellular Location Annotation
messages: Cytoplasm

2781774:ISP08 RS09375
gene id: 2781774:ISP08_RS09375
uniprot id: A0A7T1AYP6
names: Similarity
messages: Belongs to the ArsC family.

2781774:ISP08 RS02275
gene id: 2781774:ISP08_RS02275
uniprot id: A0A7T1B0Q5
names: Similarity
messages: Belongs to the TPP enzyme family.

2781774:ISP08 RS03565
gene id: 2781774:ISP08_RS03565
uniprot id: A0A7T1B143
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

2781774:ISP08 RS12475
gene id: 2781774:ISP08_RS12475
uniprot id: A0A7T1AZR9
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

2781774:ISP08 RS03560
gene id: 2781774:ISP08_RS03560
uniprot id: A0A7T1B159
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

2781774:ISP08 RS04810
gene id: 2781774:ISP08_RS04810
uniprot id: A0A7T1B1J3
names: Similarity
messages: Belongs to the UPF0374 family.

2781774:ISP08 RS01260
gene id: 2781774:ISP08_RS01260
uniprot id: A0A7T1B0B5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for heme-iron. Responsible for the translocation of the substrate across the membrane.

2781774:ISP08 RS10925
gene id: 2781774:ISP08_RS10925
uniprot id: A0A7T1F9C1
names: Similarity
messages: Belongs to the DCK/DGK family.

2781774:ISP08 RS08880
gene id: 2781774:ISP08_RS08880
uniprot id: A0A7T1AYX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

2781774:ISP08 RS09385
gene id: 2781774:ISP08_RS09385
uniprot id: A0A7T1AYN6
names: Similarity
messages: Belongs to the nitroreductase family.

2781774:ISP08 RS04830
gene id: 2781774:ISP08_RS04830
uniprot id: A0A7T1B1N4
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Homodimer; disulfide-linked, upon oxidation. 5 homodimers assemble to form a ring-like decamer.

2781774:ISP08 RS06365
gene id: 2781774:ISP08_RS06365
uniprot id: A0A7T1AXM8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flotillin-like FloA family.
messages: Cell membrane
messages: Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.
messages: Homooligomerizes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane raft

2781774:ISP08 RS08095
gene id: 2781774:ISP08_RS08095
uniprot id: A0A7T1AY84
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS00825
gene id: 2781774:ISP08_RS00825
uniprot id: A0A7T1B044
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRP transporter (TC 2.A.7.5) family.
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS03490
gene id: 2781774:ISP08_RS03490
uniprot id: A0A7T1B135
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

2781774:ISP08 RS10585
gene id: 2781774:ISP08_RS10585
uniprot id: A0A7T1AZ51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS11460
gene id: 2781774:ISP08_RS11460
uniprot id: A0A7T1AZD9
names: Function
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi.

2781774:ISP08 RS11450
gene id: 2781774:ISP08_RS11450
uniprot id: A0A7T1F958
names: Function
names: Similarity
messages: Belongs to the SpoVG family.
messages: Could be involved in septation.

2781774:ISP08 RS10385
gene id: 2781774:ISP08_RS10385
uniprot id: A0A7T1F9K1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

2781774:ISP08 RS05675
gene id: 2781774:ISP08_RS05675
uniprot id: A0A7T1B1V7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

2781774:ISP08 RS01880
gene id: 2781774:ISP08_RS01880
uniprot id: A0A7T1B0L6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS03265
gene id: 2781774:ISP08_RS03265
uniprot id: A0A7T1B109
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS03260
gene id: 2781774:ISP08_RS03260
uniprot id: A0A7T1B115
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS03100
gene id: 2781774:ISP08_RS03100
uniprot id: A0A7T1B0Z7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide.

2781774:ISP08 RS08450
gene id: 2781774:ISP08_RS08450
uniprot id: A0A7T1AYI4
names: Similarity
messages: Belongs to the UPF0358 family.

2781774:ISP08 RS03540
gene id: 2781774:ISP08_RS03540
uniprot id: A0A7T1FA02
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

2781774:ISP08 RS10235
gene id: 2781774:ISP08_RS10235
uniprot id: A0A7T1F9J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0053 family.
messages: Membrane

2781774:ISP08 RS04410
gene id: 2781774:ISP08_RS04410
uniprot id: A0A7T1B1D6
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

2781774:ISP08 RS07810
gene id: 2781774:ISP08_RS07810
uniprot id: A0A7T1AYA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

2781774:ISP08 RS11375
gene id: 2781774:ISP08_RS11375
uniprot id: A0A7T1AZI0
names: Similarity
names: Subunit
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.
messages: Homodimer.

2781774:ISP08 RS04125
gene id: 2781774:ISP08_RS04125
uniprot id: A0A7T1FAM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

2781774:ISP08 RS02260
gene id: 2781774:ISP08_RS02260
uniprot id: A0A7T1FA22
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

2781774:ISP08 RS03145
gene id: 2781774:ISP08_RS03145
uniprot id: A0A7T1B102
names: Similarity
messages: Belongs to the AHA1 family.

2781774:ISP08 RS07835
gene id: 2781774:ISP08_RS07835
uniprot id: A0A7T1F8S2
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

2781774:ISP08 RS04045
gene id: 2781774:ISP08_RS04045
uniprot id: A0A7T1FA34
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

2781774:ISP08 RS06355
gene id: 2781774:ISP08_RS06355
uniprot id: A0A7T1F8T7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

2781774:ISP08 RS05730
gene id: 2781774:ISP08_RS05730
uniprot id: A0A7T1B1X2
names: Similarity
messages: Belongs to the universal stress protein A family.

2781774:ISP08 RS02500
gene id: 2781774:ISP08_RS02500
uniprot id: A0A7T1FA32
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS08930
gene id: 2781774:ISP08_RS08930
uniprot id: A0A7T1F8R9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

2781774:ISP08 RS08220
gene id: 2781774:ISP08_RS08220
uniprot id: A0A7T1AYQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsL family.
messages: Cell membrane
messages: Essential cell division protein.
messages: Membrane

2781774:ISP08 RS12785
gene id: 2781774:ISP08_RS12785
uniprot id: A0A7T1AZU7
names: Similarity
messages: Belongs to the ParB family.

2781774:ISP08 RS04010
gene id: 2781774:ISP08_RS04010
uniprot id: A0A7T1B1E4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

2781774:ISP08 RS04270
gene id: 2781774:ISP08_RS04270
uniprot id: A0A7T1B1F1
names: Function
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.
messages: Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B.

2781774:ISP08 RS06905
gene id: 2781774:ISP08_RS06905
uniprot id: A0A7T1AXT3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

2781774:ISP08 RS06625
gene id: 2781774:ISP08_RS06625
uniprot id: A0A7T1F8T4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

2781774:ISP08 RS09340
gene id: 2781774:ISP08_RS09340
uniprot id: A0A7T1AYP7
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

2781774:ISP08 RS05785
gene id: 2781774:ISP08_RS05785
uniprot id: A0A7T1B1U5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

2781774:ISP08 RS06125
gene id: 2781774:ISP08_RS06125
uniprot id: A0A7T1B213
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

2781774:ISP08 RS06390
gene id: 2781774:ISP08_RS06390
uniprot id: A0A7T1F8R8
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

2781774:ISP08 RS03610
gene id: 2781774:ISP08_RS03610
uniprot id: A0A7T1B164
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

2781774:ISP08 RS05805
gene id: 2781774:ISP08_RS05805
uniprot id: A0A7T1B1X7
names: Similarity
messages: Belongs to the citrate synthase family.

2781774:ISP08 RS02870
gene id: 2781774:ISP08_RS02870
uniprot id: A0A7T1B177
names: Function
messages: Repressor of the lactose catabolism operon. Galactose-6-phosphate is the inducer.

2781774:ISP08 RS10880
gene id: 2781774:ISP08_RS10880
uniprot id: A0A7T1AZ98
names: Function
names: Similarity
messages: Belongs to the HPS/KGPDC family. HPS subfamily.
messages: Catalyzes the condensation of ribulose 5-phosphate with formaldehyde to form 3-hexulose 6-phosphate.

2781774:ISP08 RS09930
gene id: 2781774:ISP08_RS09930
uniprot id: A0A7T1AYV3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

2781774:ISP08 RS06205
gene id: 2781774:ISP08_RS06205
uniprot id: A0A7T1B206
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

2781774:ISP08 RS07950
gene id: 2781774:ISP08_RS07950
uniprot id: A0A7T1F922
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

2781774:ISP08 RS03510
gene id: 2781774:ISP08_RS03510
uniprot id: A0A7T1B186
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

2781774:ISP08 RS04745
gene id: 2781774:ISP08_RS04745
uniprot id: A0A7T1FAH7
names: Similarity
messages: Belongs to the UPF0435 family.

2781774:ISP08 RS09890
gene id: 2781774:ISP08_RS09890
uniprot id: A0A7T1AYV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

2781774:ISP08 RS00775
gene id: 2781774:ISP08_RS00775
uniprot id: A0A7T1B056
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

2781774:ISP08 RS00165
gene id: 2781774:ISP08_RS00165
uniprot id: A0A7T1F9E1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family. Thioredoxin-coupled ArsC subfamily.
messages: Catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)].
messages: Cytoplasm

2781774:ISP08 RS07820
gene id: 2781774:ISP08_RS07820
uniprot id: A0A7T1AY51
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

2781774:ISP08 RS07425
gene id: 2781774:ISP08_RS07425
uniprot id: A0A7T1AY00
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

2781774:ISP08 RS03185
gene id: 2781774:ISP08_RS03185
uniprot id: A0A7T1B0Z8
names: Subcellular Location Annotation
messages: Membrane

2781774:ISP08 RS07560
gene id: 2781774:ISP08_RS07560
uniprot id: A0A7T1F8K3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback-inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation. Under conditions of nitrogen excess, feedback-inhibited GlnA forms a stable complex with TnrA, which inhibits its DNA-binding activity. In contrast, feedback-inhibited GlnA acts as a chaperone to stabilize the DNA-binding activity of GlnR, which represses the transcription of nitrogen assimilation genes.
messages: Oligomer of 12 subunits arranged in the form of two hexagons. In its feedback-inhibited form, interacts with TnrA in order to block its DNA-binding activity.

2781774:ISP08 RS02505
gene id: 2781774:ISP08_RS02505
uniprot id: A0A7T1B0V0
names: Similarity
messages: Belongs to the TRAP family.

2781774:ISP08 RS07350
gene id: 2781774:ISP08_RS07350
uniprot id: A0A7T1AXZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS07680
gene id: 2781774:ISP08_RS07680
uniprot id: A0A7T1F8R4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

2781774:ISP08 RS03325
gene id: 2781774:ISP08_RS03325
uniprot id: A0A7T1F9Y1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

2781774:ISP08 RS07390
gene id: 2781774:ISP08_RS07390
uniprot id: A0A7T1AXZ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

2781774:ISP08 RS12675
gene id: 2781774:ISP08_RS12675
uniprot id: A0A7T1AZT0
names: Subcellular Location Annotation
messages: Membrane

2781774:ISP08 RS00365
gene id: 2781774:ISP08_RS00365
uniprot id: A0A7T1B004
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

2781774:ISP08 RS08430
gene id: 2781774:ISP08_RS08430
uniprot id: A0A7T1AYC3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Interacts with CtaA.
messages: Membrane

2781774:ISP08 RS04085
gene id: 2781774:ISP08_RS04085
uniprot id: A0A7T1FAD8
names: Subcellular Location Annotation
messages: Membrane

2781774:ISP08 RS03515
gene id: 2781774:ISP08_RS03515
uniprot id: A0A7T1FAJ6
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

2781774:ISP08 RS03840
gene id: 2781774:ISP08_RS03840
uniprot id: A0A7T1B175
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

2781774:ISP08 RS10115
gene id: 2781774:ISP08_RS10115
uniprot id: A0A7T1F9H0
names: Similarity
messages: Belongs to the EamA transporter family.

2781774:ISP08 RS12630
gene id: 2781774:ISP08_RS12630
uniprot id: A0A7T1F9X9
names: Subcellular Location Annotation
messages: Membrane

2781774:ISP08 RS07905
gene id: 2781774:ISP08_RS07905
uniprot id: A0A7T1AY56
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

2781774:ISP08 RS10715
gene id: 2781774:ISP08_RS10715
uniprot id: A0A7T1AZ63
names: Similarity
names: Subunit
messages: Belongs to the azoreductase type 2 family.
messages: Homotetramer.

2781774:ISP08 RS04250
gene id: 2781774:ISP08_RS04250
uniprot id: A0A7T1B1G4
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

2781774:ISP08 RS03845
gene id: 2781774:ISP08_RS03845
uniprot id: A0A7T1B1I4
names: Similarity
messages: Belongs to the mannitol dehydrogenase family.

2781774:ISP08 RS01865
gene id: 2781774:ISP08_RS01865
uniprot id: A0A7T1B0N8
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

2781774:ISP08 RS09950
gene id: 2781774:ISP08_RS09950
uniprot id: A0A7T1F8X0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

2781774:ISP08 RS03045
gene id: 2781774:ISP08_RS03045
uniprot id: A0A7T1B118
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.
messages: Catalyzes the sodium-dependent transport of glutamate.
messages: Cell membrane

2781774:ISP08 RS10535
gene id: 2781774:ISP08_RS10535
uniprot id: A0A7T1F9L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS09335
gene id: 2781774:ISP08_RS09335
uniprot id: A0A7T1AYT2
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

2781774:ISP08 RS00945
gene id: 2781774:ISP08_RS00945
uniprot id: A0A7T1B078
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the staphylococcal hemolytic protein family.
messages: Secreted

2781774:ISP08 RS03735
gene id: 2781774:ISP08_RS03735
uniprot id: A0A7T1FAB8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta-bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.
messages: Belongs to the TRAP family.
messages: Belongs to the antibiotic biosynthesis monooxygenase family. Heme-degrading monooxygenase IsdG subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2781774:ISP08 RS05830
gene id: 2781774:ISP08_RS05830
uniprot id: A0A7T1B1X4
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Monomer.

2781774:ISP08 RS04685
gene id: 2781774:ISP08_RS04685
uniprot id: A0A7T1B1L1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

2781774:ISP08 RS11440
gene id: 2781774:ISP08_RS11440
uniprot id: A0A7T1F959
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
messages: Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi.

2781774:ISP08 RS05655
gene id: 2781774:ISP08_RS05655
uniprot id: A0A7T1FAT9
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

2781774:ISP08 RS08205
gene id: 2781774:ISP08_RS08205
uniprot id: A0A7T1AYF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

2781774:ISP08 RS06080
gene id: 2781774:ISP08_RS06080
uniprot id: A0A7T1B1Y5
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp.

2781774:ISP08 RS07430
gene id: 2781774:ISP08_RS07430
uniprot id: A0A7T1AYC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0291 family.
messages: Cytoplasm

2781774:ISP08 RS06465
gene id: 2781774:ISP08_RS06465
uniprot id: A0A7T1F8G8
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

2781774:ISP08 RS04595
gene id: 2781774:ISP08_RS04595
uniprot id: A0A7T1FAG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

2781774:ISP08 RS03495
gene id: 2781774:ISP08_RS03495
uniprot id: A0A7T1B1E1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

2781774:ISP08 RS10340
gene id: 2781774:ISP08_RS10340
uniprot id: A0A7T1F9I8
names: Similarity
messages: Belongs to the LOG family.

2781774:ISP08 RS12810
gene id: 2781774:ISP08_RS12810
uniprot id: A0A7T1AZX9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

2781774:ISP08 RS02645
gene id: 2781774:ISP08_RS02645
uniprot id: A0A7T1B0T3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. L-carnitine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3-dehydrocarnitine.
messages: Cytoplasm
messages: Homodimer.

2781774:ISP08 RS08370
gene id: 2781774:ISP08_RS08370
uniprot id: A0A7T1AYH5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

2781774:ISP08 RS07500
gene id: 2781774:ISP08_RS07500
uniprot id: A0A7T1AY15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.
messages: Cytoplasm

2781774:ISP08 RS05715
gene id: 2781774:ISP08_RS05715
uniprot id: A0A7T1B267
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peroxiredoxin family. Tpx subfamily.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

2781774:ISP08 RS11215
gene id: 2781774:ISP08_RS11215
uniprot id: A0A7T1B266
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

2781774:ISP08 RS06640
gene id: 2781774:ISP08_RS06640
uniprot id: A0A7T1AXP0
names: Function
names: Similarity
messages: Belongs to the BCKDHA family.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

2781774:ISP08 RS02745
gene id: 2781774:ISP08_RS02745
uniprot id: A0A7T1B0W0
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

2781774:ISP08 RS03625
gene id: 2781774:ISP08_RS03625
uniprot id: A0A7T1FA07
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

2781774:ISP08 RS07920
gene id: 2781774:ISP08_RS07920
uniprot id: A0A7T1F949
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

2781774:ISP08 RS07965
gene id: 2781774:ISP08_RS07965
uniprot id: A0A7T1AYD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

2781774:ISP08 RS01965
gene id: 2781774:ISP08_RS01965
uniprot id: A0A7T1B0M3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.

2781774:ISP08 RS07730
gene id: 2781774:ISP08_RS07730
uniprot id: A0A7T1F8K2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

2781774:ISP08 RS01705
gene id: 2781774:ISP08_RS01705
uniprot id: A0A7T1F9Z3
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2781774:ISP08 RS01855
gene id: 2781774:ISP08_RS01855
uniprot id: A0A7T1B0G9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

2781774:ISP08 RS06395
gene id: 2781774:ISP08_RS06395
uniprot id: A0A7T1F8F2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

2781774:ISP08 RS04135
gene id: 2781774:ISP08_RS04135
uniprot id: A0A7T1B254
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2781774:ISP08 RS07840
gene id: 2781774:ISP08_RS07840
uniprot id: A0A7T1AY68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CodY family.
messages: Cytoplasm
messages: DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability. During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion.

2781774:ISP08 RS10690
gene id: 2781774:ISP08_RS10690
uniprot id: A0A7T1F9A2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

2781774:ISP08 RS07790
gene id: 2781774:ISP08_RS07790
uniprot id: A0A7T1AY40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

2781774:ISP08 RS06945
gene id: 2781774:ISP08_RS06945
uniprot id: A0A7T1AXS8
names: Subcellular Location Annotation
messages: Cytoplasm

2781774:ISP08 RS00080
gene id: 2781774:ISP08_RS00080
uniprot id: A0A7T1AZW2
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

2781774:ISP08 RS02335
gene id: 2781774:ISP08_RS02335
uniprot id: A0A7T1FA25
names: Function
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Catalyzes the NADPH dependent reduction of D-ribulose 5-phosphate to D-ribitol 5-phosphate.

2781774:ISP08 RS06820
gene id: 2781774:ISP08_RS06820
uniprot id: A0A7T1AXT8
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

2781774:ISP08 RS04280
gene id: 2781774:ISP08_RS04280
uniprot id: A0A7T1FAW1
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

2781774:ISP08 RS08785
gene id: 2781774:ISP08_RS08785
uniprot id: A0A7T1AYF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MenH family.
messages: Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).
messages: Monomer.

2781774:ISP08 RS09195
gene id: 2781774:ISP08_RS09195
uniprot id: A0A7T1AZ10
names: Similarity
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit G family.

2781774:ISP08 RS06840
gene id: 2781774:ISP08_RS06840
uniprot id: A0A7T1AXS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

2781774:ISP08 RS04440
gene id: 2781774:ISP08_RS04440
uniprot id: A0A7T1B1I6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AgrB family.
messages: Cell membrane
messages: Essential for the production of a quorum sensing system signal molecule, the autoinducing peptide (AIP). This quorum sensing system is responsible for the regulation of the expression of virulence factor genes. Involved in the proteolytic processing of AgrD, the precursor of AIP.

2781774:ISP08 RS08255
gene id: 2781774:ISP08_RS08255
uniprot id: A0A7T1AYA0
names: Similarity
messages: Belongs to the TRAP family.

2781774:ISP08 RS06810
gene id: 2781774:ISP08_RS06810
uniprot id: A0A7T1AXS5
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

2781774:ISP08 RS09300
gene id: 2781774:ISP08_RS09300
uniprot id: A0A7T1AYL0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

2781774:ISP08 RS08075
gene id: 2781774:ISP08_RS08075
uniprot id: A0A7T1AY97
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

2781774:ISP08 RS07185
gene id: 2781774:ISP08_RS07185
uniprot id: A0A7T1AXX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.
messages: Cytoplasm

2781774:ISP08 RS12805
gene id: 2781774:ISP08_RS12805
uniprot id: A0A7T1F9D3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

2781774:ISP08 RS09945
gene id: 2781774:ISP08_RS09945
uniprot id: A0A7T1AYV9
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

2781774:ISP08 RS07690
gene id: 2781774:ISP08_RS07690
uniprot id: A0A7T1F935
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane
messages: This protein catalyzes the committed step to the synthesis of the acidic phospholipids.

2781774:ISP08 RS09855
gene id: 2781774:ISP08_RS09855
uniprot id: A0A7T1AYU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

2781774:ISP08 RS04340
gene id: 2781774:ISP08_RS04340
uniprot id: A0A7T1B1Q5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
messages: Homodimer.

2781774:ISP08 RS06200
gene id: 2781774:ISP08_RS06200
uniprot id: A0A7T1B217
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

2781774:ISP08 RS05905
gene id: 2781774:ISP08_RS05905
uniprot id: A0A7T1B1W2
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

2781774:ISP08 RS04035
gene id: 2781774:ISP08_RS04035
uniprot id: A0A7T1B1B9
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

2781774:ISP08 RS06600
gene id: 2781774:ISP08_RS06600
uniprot id: A0A7T1AXQ0
names: Function
names: Similarity
messages: Belongs to the asp23 family.
messages: May play a key role in alkaline pH tolerance.

2781774:ISP08 RS07825
gene id: 2781774:ISP08_RS07825
uniprot id: A0A7T1AYJ1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2781774:ISP08 RS07815
gene id: 2781774:ISP08_RS07815
uniprot id: A0A7T1AY64
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

2781774:ISP08 RS08140
gene id: 2781774:ISP08_RS08140
uniprot id: A0A7T1AYN4
names: Function
names: Similarity
names: Subunit
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Homodimer and homohexamer; in equilibrium.
messages: Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi.
messages: Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.

2781774:ISP08 RS00375
gene id: 2781774:ISP08_RS00375
uniprot id: A0A7T1B058
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

2781774:ISP08 RS02265
gene id: 2781774:ISP08_RS02265
uniprot id: A0A7T1B0S5
names: Subcellular Location Annotation
messages: Membrane

2781774:ISP08 RS03600
gene id: 2781774:ISP08_RS03600
uniprot id: A0A7T1B154
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

2781774:ISP08 RS06090
gene id: 2781774:ISP08_RS06090
uniprot id: A0A7T1B1Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family.
messages: Probably involved in cell-wall metabolism.
messages: Secreted

2781774:ISP08 RS09280
gene id: 2781774:ISP08_RS09280
uniprot id: A0A7T1F913
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. NagD family.
messages: Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro.
messages: Divalent metal ions. Mg(2+) is the most effective.

2781774:ISP08 RS09190
gene id: 2781774:ISP08_RS09190
uniprot id: A0A7T1AYK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS08170
gene id: 2781774:ISP08_RS08170
uniprot id: A0A7T1AYA5
names: Similarity
messages: Belongs to the YggT family.

2781774:ISP08 RS03530
gene id: 2781774:ISP08_RS03530
uniprot id: A0A7T1B142
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

2781774:ISP08 RS01885
gene id: 2781774:ISP08_RS01885
uniprot id: A0A7T1B0H2
names: Subcellular Location Annotation
messages: Membrane

2781774:ISP08 RS10970
gene id: 2781774:ISP08_RS10970
uniprot id: A0A7T1F936
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

2781774:ISP08 RS10100
gene id: 2781774:ISP08_RS10100
uniprot id: A0A7T1AYY5
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Tetramer of two alpha and two beta subunits.

2781774:ISP08 RS07015
gene id: 2781774:ISP08_RS07015
uniprot id: A0A7T1F8G9
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

2781774:ISP08 RS03575
gene id: 2781774:ISP08_RS03575
uniprot id: A0A7T1B150
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

2781774:ISP08 RS03690
gene id: 2781774:ISP08_RS03690
uniprot id: A0A7T1B174
names: Function
names: Similarity
messages: Belongs to the asp23 family.
messages: May play a key role in alkaline pH tolerance.

2781774:ISP08 RS09185
gene id: 2781774:ISP08_RS09185
uniprot id: A0A7T1AYM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS04645
gene id: 2781774:ISP08_RS04645
uniprot id: A0A7T1B1H1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

2781774:ISP08 RS10945
gene id: 2781774:ISP08_RS10945
uniprot id: A0A7T1AZA9
names: Similarity
messages: Belongs to the 4-oxalocrotonate tautomerase family.

2781774:ISP08 RS02045
gene id: 2781774:ISP08_RS02045
uniprot id: A0A7T1B0J4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

2781774:ISP08 RS03630
gene id: 2781774:ISP08_RS03630
uniprot id: A0A7T1B163
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

2781774:ISP08 RS08950
gene id: 2781774:ISP08_RS08950
uniprot id: A0A7T1AYL5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2781774:ISP08 RS04350
gene id: 2781774:ISP08_RS04350
uniprot id: A0A7T1FAF3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

2781774:ISP08 RS07605
gene id: 2781774:ISP08_RS07605
uniprot id: A0A7T1AY24
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the FGGY kinase family.
messages: Homotetramer and homodimer (in equilibrium).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), including enzyme I, and histidine-containing protein (HPr) are required for the phosphorylation, which leads to the activation of the enzyme.

2781774:ISP08 RS11160
gene id: 2781774:ISP08_RS11160
uniprot id: A0A7T1F9D4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

2781774:ISP08 RS10590
gene id: 2781774:ISP08_RS10590
uniprot id: A0A7T1AZI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family.
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS11130
gene id: 2781774:ISP08_RS11130
uniprot id: A0A7T1AZF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

2781774:ISP08 RS00930
gene id: 2781774:ISP08_RS00930
uniprot id: A0A7T1F9I7
names: Subcellular Location Annotation
messages: Membrane

2781774:ISP08 RS06175
gene id: 2781774:ISP08_RS06175
uniprot id: A0A7T1B2B0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

2781774:ISP08 RS03500
gene id: 2781774:ISP08_RS03500
uniprot id: A0A7T1B144
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

2781774:ISP08 RS09155
gene id: 2781774:ISP08_RS09155
uniprot id: A0A7T1B2D3
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

2781774:ISP08 RS09395
gene id: 2781774:ISP08_RS09395
uniprot id: A0A7T1F8U4
names: Similarity
messages: Belongs to the OsmC/Ohr family.

2781774:ISP08 RS08465
gene id: 2781774:ISP08_RS08465
uniprot id: A0A7T1AYS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

2781774:ISP08 RS08905
gene id: 2781774:ISP08_RS08905
uniprot id: A0A7T1F9B3
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. YjcG family.

2781774:ISP08 RS05595
gene id: 2781774:ISP08_RS05595
uniprot id: A0A7T1B1S2
names: Function
messages: Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions.

2781774:ISP08 RS03105
gene id: 2781774:ISP08_RS03105
uniprot id: A0A7T1B0Z1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

2781774:ISP08 RS03525
gene id: 2781774:ISP08_RS03525
uniprot id: A0A7T1B149
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

2781774:ISP08 RS08000
gene id: 2781774:ISP08_RS08000
uniprot id: A0A7T1F956
names: Function
names: Similarity
messages: Belongs to the asp23 family.
messages: May play a key role in alkaline pH tolerance.

2781774:ISP08 RS06040
gene id: 2781774:ISP08_RS06040
uniprot id: A0A7T1FAV5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

2781774:ISP08 RS02220
gene id: 2781774:ISP08_RS02220
uniprot id: A0A7T1FAB3
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family. RocA subfamily.

2781774:ISP08 RS09425
gene id: 2781774:ISP08_RS09425
uniprot id: A0A7T1B273
names: Subcellular Location Annotation
messages: Membrane

2781774:ISP08 RS11860
gene id: 2781774:ISP08_RS11860
uniprot id: A0A7T1AZK0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein.

2781774:ISP08 RS05800
gene id: 2781774:ISP08_RS05800
uniprot id: A0A7T1FAM2
names: Subcellular Location Annotation
messages: Membrane

2781774:ISP08 RS03040
gene id: 2781774:ISP08_RS03040
uniprot id: A0A7T1FA68
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2781774:ISP08 RS11170
gene id: 2781774:ISP08_RS11170
uniprot id: A0A7T1F9Q2
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

2781774:ISP08 RS09000
gene id: 2781774:ISP08_RS09000
uniprot id: A0A7T1AYI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArsC family. Spx subfamily.
messages: Cytoplasm
messages: Global transcriptional regulator that plays a key role in stress response and exerts either positive or negative regulation of genes. Acts by interacting with the C-terminal domain of the alpha subunit of the RNA polymerase (RNAP). This interaction can enhance binding of RNAP to the promoter region of target genes and stimulate their transcription, or block interaction of RNAP with activator.
messages: Interacts with the C-terminal domain of the alpha subunit of the RNAP.

2781774:ISP08 RS00605
gene id: 2781774:ISP08_RS00605
uniprot id: A0A7T1B035
names: Similarity
messages: Belongs to the alpha-acetolactate decarboxylase family.

2781774:ISP08 RS06835
gene id: 2781774:ISP08_RS06835
uniprot id: A0A7T1AXU5
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

2781774:ISP08 RS11690
gene id: 2781774:ISP08_RS11690
uniprot id: A0A7T1F9S4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IcaD family.
messages: Cell membrane
messages: Necessary for the synthesis of poly-beta-1,6-N-acetyl-D-glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide. Is required for full IcaA N-acetylglucosaminyltransferase activity.

2781774:ISP08 RS11560
gene id: 2781774:ISP08_RS11560
uniprot id: A0A7T1AZJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

2781774:ISP08 RS04655
gene id: 2781774:ISP08_RS04655
uniprot id: A0A7T1B1H4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

2781774:ISP08 RS00085
gene id: 2781774:ISP08_RS00085
uniprot id: A0A7T1AZW6
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

2781774:ISP08 RS08675
gene id: 2781774:ISP08_RS08675
uniprot id: A0A7T1F970
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

2781774:ISP08 RS05810
gene id: 2781774:ISP08_RS05810
uniprot id: A0A7T1FAU4
names: Cofactor
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

2781774:ISP08 RS08865
gene id: 2781774:ISP08_RS08865
uniprot id: A0A7T1AYK8
names: Subcellular Location Annotation
messages: Membrane

2781774:ISP08 RS10210
gene id: 2781774:ISP08_RS10210
uniprot id: A0A7T1AZ00
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2781774:ISP08 RS02050
gene id: 2781774:ISP08_RS02050
uniprot id: A0A7T1B0J0
names: Similarity
messages: Belongs to the ThrE exporter (TC 2.A.79) family.

2781774:ISP08 RS12160
gene id: 2781774:ISP08_RS12160
uniprot id: A0A7T1F9J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS12480
gene id: 2781774:ISP08_RS12480
uniprot id: A0A7T1B065
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

2781774:ISP08 RS05845
gene id: 2781774:ISP08_RS05845
uniprot id: A0A7T1FAD2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

2781774:ISP08 RS08940
gene id: 2781774:ISP08_RS08940
uniprot id: A0A7T1F8R2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

2781774:ISP08 RS12230
gene id: 2781774:ISP08_RS12230
uniprot id: A0A7T1AZM9
names: Similarity
messages: Belongs to the CapA family.

2781774:ISP08 RS00830
gene id: 2781774:ISP08_RS00830
uniprot id: A0A7T1B088
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbsD / FucU family. RbsD subfamily.
messages: Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
messages: Cytoplasm
messages: Homodecamer.

2781774:ISP08 RS02280
gene id: 2781774:ISP08_RS02280
uniprot id: A0A7T1B0R4
names: Subcellular Location Annotation
messages: Membrane

2781774:ISP08 RS07245
gene id: 2781774:ISP08_RS07245
uniprot id: A0A7T1F8X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FemABX family.
messages: Cytoplasm

2781774:ISP08 RS06475
gene id: 2781774:ISP08_RS06475
uniprot id: A0A7T1F8F3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

2781774:ISP08 RS08800
gene id: 2781774:ISP08_RS08800
uniprot id: A0A7T1AYI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

2781774:ISP08 RS11230
gene id: 2781774:ISP08_RS11230
uniprot id: A0A7T1AZC2
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

2781774:ISP08 RS11120
gene id: 2781774:ISP08_RS11120
uniprot id: A0A7T1F9N5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

2781774:ISP08 RS07490
gene id: 2781774:ISP08_RS07490
uniprot id: A0A7T1B275
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

2781774:ISP08 RS04120
gene id: 2781774:ISP08_RS04120
uniprot id: A0A7T1FA37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

2781774:ISP08 RS11400
gene id: 2781774:ISP08_RS11400
uniprot id: A0A7T1AZE0
names: Function
messages: Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.

2781774:ISP08 RS05790
gene id: 2781774:ISP08_RS05790
uniprot id: A0A7T1B281
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2781774:ISP08 RS11145
gene id: 2781774:ISP08_RS11145
uniprot id: A0A7T1AZB3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

2781774:ISP08 RS04330
gene id: 2781774:ISP08_RS04330
uniprot id: A0A7T1B1G0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

2781774:ISP08 RS05780
gene id: 2781774:ISP08_RS05780
uniprot id: A0A7T1B1V5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

2781774:ISP08 RS08715
gene id: 2781774:ISP08_RS08715
uniprot id: A0A7T1AYH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Catalyzes quinol oxidation with the concomitant reduction of oxygen to water.
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS09005
gene id: 2781774:ISP08_RS09005
uniprot id: A0A7T1B256
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

2781774:ISP08 RS04100
gene id: 2781774:ISP08_RS04100
uniprot id: A0A7T1B1E7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

2781774:ISP08 RS04375
gene id: 2781774:ISP08_RS04375
uniprot id: A0A7T1B1G2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein bS18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm

2781774:ISP08 RS09860
gene id: 2781774:ISP08_RS09860
uniprot id: A0A7T1AYU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.
messages: Cytoplasm

2781774:ISP08 RS04325
gene id: 2781774:ISP08_RS04325
uniprot id: A0A7T1B1D2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 1 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

2781774:ISP08 RS07465
gene id: 2781774:ISP08_RS07465
uniprot id: A0A7T1AY04
names: Similarity
names: Subunit
messages: Belongs to the catalase family.
messages: Homodimer.

2781774:ISP08 RS03480
gene id: 2781774:ISP08_RS03480
uniprot id: A0A7T1B147
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS05580
gene id: 2781774:ISP08_RS05580
uniprot id: A0A7T1FAT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0478 family.
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS07985
gene id: 2781774:ISP08_RS07985
uniprot id: A0A7T1AY66
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

2781774:ISP08 RS06990
gene id: 2781774:ISP08_RS06990
uniprot id: A0A7T1AXW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

2781774:ISP08 RS03850
gene id: 2781774:ISP08_RS03850
uniprot id: A0A7T1B180
names: Function
names: Subunit
messages: Homodimer or homotrimer. Seems to be a monomer when not phosphorylated.
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport.

2781774:ISP08 RS08210
gene id: 2781774:ISP08_RS08210
uniprot id: A0A7T1AYC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS00320
gene id: 2781774:ISP08_RS00320
uniprot id: A0A7T1AZZ7
names: Function
names: Similarity
messages: Belongs to the phytoene/squalene synthase family. CrtM subfamily.
messages: Involved in the biosynthesis of the yellow-orange carotenoid staphyloxanthin, which plays a role in the virulence via its protective function against oxidative stress. Catalyzes the head-to-head condensation of two molecules of farnesyl diphosphate (FPP) into the colorless C(30) carotenoid 4,4'-diapophytoene (dehydrosqualene).

2781774:ISP08 RS07205
gene id: 2781774:ISP08_RS07205
uniprot id: A0A7T1AXX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PstS family.
messages: Cell membrane
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

2781774:ISP08 RS09960
gene id: 2781774:ISP08_RS09960
uniprot id: A0A7T1F8X7
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

2781774:ISP08 RS06800
gene id: 2781774:ISP08_RS06800
uniprot id: A0A7T1AXS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

2781774:ISP08 RS04740
gene id: 2781774:ISP08_RS04740
uniprot id: A0A7T1B1J1
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

2781774:ISP08 RS04260
gene id: 2781774:ISP08_RS04260
uniprot id: A0A7T1B1F8
names: Function
names: Similarity
messages: Belongs to the PemK/MazF family.
messages: Toxic component of a type II toxin-antitoxin (TA) system.

2781774:ISP08 RS06275
gene id: 2781774:ISP08_RS06275
uniprot id: A0A7T1AXL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

2781774:ISP08 RS07040
gene id: 2781774:ISP08_RS07040
uniprot id: A0A7T1AXU8
names: Similarity
messages: Belongs to the UPF0346 family.

2781774:ISP08 RS11635
gene id: 2781774:ISP08_RS11635
uniprot id: A0A7T1F9R3
names: Similarity
messages: Belongs to the Nudix hydrolase family.

2781774:ISP08 RS07615
gene id: 2781774:ISP08_RS07615
uniprot id: A0A7T1AY36
names: Function
messages: Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA.

2781774:ISP08 RS03550
gene id: 2781774:ISP08_RS03550
uniprot id: A0A7T1FA01
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

2781774:ISP08 RS02185
gene id: 2781774:ISP08_RS02185
uniprot id: A0A7T1B0R9
names: Subcellular Location Annotation
messages: Membrane

2781774:ISP08 RS08790
gene id: 2781774:ISP08_RS08790
uniprot id: A0A7T1F8Y7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

2781774:ISP08 RS11155
gene id: 2781774:ISP08_RS11155
uniprot id: A0A7T1AZC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

2781774:ISP08 RS00310
gene id: 2781774:ISP08_RS00310
uniprot id: A0A7T1AZY4
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

2781774:ISP08 RS08310
gene id: 2781774:ISP08_RS08310
uniprot id: A0A7T1AYA6
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

2781774:ISP08 RS10595
gene id: 2781774:ISP08_RS10595
uniprot id: A0A7T1AZ42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit C family.
messages: Membrane

2781774:ISP08 RS06960
gene id: 2781774:ISP08_RS06960
uniprot id: A0A7T1AY74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

2781774:ISP08 RS07645
gene id: 2781774:ISP08_RS07645
uniprot id: A0A7T1F901
names: Similarity
messages: Belongs to the UPF0045 family.

2781774:ISP08 RS09990
gene id: 2781774:ISP08_RS09990
uniprot id: A0A7T1AYV7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

2781774:ISP08 RS09135
gene id: 2781774:ISP08_RS09135
uniprot id: A0A7T1F9C7
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

2781774:ISP08 RS03215
gene id: 2781774:ISP08_RS03215
uniprot id: A0A7T1FAG9
names: Function
messages: Repressor of the lactose catabolism operon. Galactose-6-phosphate is the inducer.

2781774:ISP08 RS02670
gene id: 2781774:ISP08_RS02670
uniprot id: A0A7T1B0U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS03555
gene id: 2781774:ISP08_RS03555
uniprot id: A0A7T1B157
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

2781774:ISP08 RS10325
gene id: 2781774:ISP08_RS10325
uniprot id: A0A7T1AZ14
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS06170
gene id: 2781774:ISP08_RS06170
uniprot id: A0A7T1B200
names: Similarity
messages: Belongs to the UPF0297 family.

2781774:ISP08 RS09170
gene id: 2781774:ISP08_RS09170
uniprot id: A0A7T1F998
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit B family.
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS08080
gene id: 2781774:ISP08_RS08080
uniprot id: A0A7T1F961
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

2781774:ISP08 RS07320
gene id: 2781774:ISP08_RS07320
uniprot id: A0A7T1F8Y2
names: Similarity
messages: Belongs to the 4-oxalocrotonate tautomerase family.

2781774:ISP08 RS10110
gene id: 2781774:ISP08_RS10110
uniprot id: A0A7T1F8X8
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

2781774:ISP08 RS08325
gene id: 2781774:ISP08_RS08325
uniprot id: A0A7T1F980
names: Function
names: Similarity
messages: Belongs to the thioredoxin family.
messages: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.

2781774:ISP08 RS06605
gene id: 2781774:ISP08_RS06605
uniprot id: A0A7T1AXR3
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

2781774:ISP08 RS07135
gene id: 2781774:ISP08_RS07135
uniprot id: A0A7T1AXW1
names: Similarity
messages: Belongs to the acylphosphatase family.

2781774:ISP08 RS07990
gene id: 2781774:ISP08_RS07990
uniprot id: A0A7T1F8T3
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

2781774:ISP08 RS04090
gene id: 2781774:ISP08_RS04090
uniprot id: A0A7T1B1E6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

2781774:ISP08 RS12635
gene id: 2781774:ISP08_RS12635
uniprot id: A0A7T1F9C5
names: Subcellular Location Annotation
messages: Membrane

2781774:ISP08 RS06060
gene id: 2781774:ISP08_RS06060
uniprot id: A0A7T1B205
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

2781774:ISP08 RS04095
gene id: 2781774:ISP08_RS04095
uniprot id: A0A7T1FAN0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

2781774:ISP08 RS02370
gene id: 2781774:ISP08_RS02370
uniprot id: A0A7T1B223
names: Function
names: Similarity
messages: Belongs to the NanE family.
messages: Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).

2781774:ISP08 RS00065
gene id: 2781774:ISP08_RS00065
uniprot id: A0A7T1F9Z1
names: Similarity
messages: Belongs to the AB hydrolase superfamily.

2781774:ISP08 RS06590
gene id: 2781774:ISP08_RS06590
uniprot id: A0A7T1AXP5
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

2781774:ISP08 RS11820
gene id: 2781774:ISP08_RS11820
uniprot id: A0A7T1AZJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
messages: Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi.

2781774:ISP08 RS04225
gene id: 2781774:ISP08_RS04225
uniprot id: A0A7T1B1F2
names: Similarity
messages: Belongs to the DEAD box helicase family.

2781774:ISP08 RS09870
gene id: 2781774:ISP08_RS09870
uniprot id: A0A7T1F8W5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

2781774:ISP08 RS06425
gene id: 2781774:ISP08_RS06425
uniprot id: A0A7T1AXM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

2781774:ISP08 RS03570
gene id: 2781774:ISP08_RS03570
uniprot id: A0A7T1B1F4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

2781774:ISP08 RS08175
gene id: 2781774:ISP08_RS08175
uniprot id: A0A7T1AY94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepF family.
messages: Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
messages: Cytoplasm
messages: Homodimer. Interacts with FtsZ.

2781774:ISP08 RS10140
gene id: 2781774:ISP08_RS10140
uniprot id: A0A7T1AZB9
names: Function
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.
messages: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides.

2781774:ISP08 RS07935
gene id: 2781774:ISP08_RS07935
uniprot id: A0A7T1AY65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

2781774:ISP08 RS10920
gene id: 2781774:ISP08_RS10920
uniprot id: A0A7T1AZ84
names: Similarity
messages: Belongs to the DCK/DGK family.

2781774:ISP08 RS02890
gene id: 2781774:ISP08_RS02890
uniprot id: A0A7T1B0Z6
names: Similarity
messages: Belongs to the LacAB/RpiB family.

2781774:ISP08 RS06725
gene id: 2781774:ISP08_RS06725
uniprot id: A0A7T1AY44
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

2781774:ISP08 RS10525
gene id: 2781774:ISP08_RS10525
uniprot id: A0A7T1F993
names: Subcellular Location Annotation
messages: Membrane

2781774:ISP08 RS11115
gene id: 2781774:ISP08_RS11115
uniprot id: A0A7T1F943
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

2781774:ISP08 RS08595
gene id: 2781774:ISP08_RS08595
uniprot id: A0A7T1F964
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

2781774:ISP08 RS05875
gene id: 2781774:ISP08_RS05875
uniprot id: A0A7T1B1W4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

2781774:ISP08 RS09900
gene id: 2781774:ISP08_RS09900
uniprot id: A0A7T1AZ94
names: Function
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.

2781774:ISP08 RS10220
gene id: 2781774:ISP08_RS10220
uniprot id: A0A7T1AYZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

2781774:ISP08 RS00090
gene id: 2781774:ISP08_RS00090
uniprot id: A0A7T1B230
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

2781774:ISP08 RS03960
gene id: 2781774:ISP08_RS03960
uniprot id: A0A7T1B199
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Binds 1 Fe cation per subunit.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

2781774:ISP08 RS10405
gene id: 2781774:ISP08_RS10405
uniprot id: A0A7T1AZ37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family. YeeN subfamily.
messages: Cytoplasm

2781774:ISP08 RS10490
gene id: 2781774:ISP08_RS10490
uniprot id: A0A7T1F9J4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS06380
gene id: 2781774:ISP08_RS06380
uniprot id: A0A7T1AXP3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

2781774:ISP08 RS09980
gene id: 2781774:ISP08_RS09980
uniprot id: A0A7T1AYW8
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
messages: Homohexamer.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

2781774:ISP08 RS07675
gene id: 2781774:ISP08_RS07675
uniprot id: A0A7T1AY22
names: Function
names: Similarity
messages: Belongs to the RNase Y family.
messages: Endoribonuclease that initiates mRNA decay.

2781774:ISP08 RS11165
gene id: 2781774:ISP08_RS11165
uniprot id: A0A7T1AZE9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

2781774:ISP08 RS03585
gene id: 2781774:ISP08_RS03585
uniprot id: A0A7T1B189
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

2781774:ISP08 RS02970
gene id: 2781774:ISP08_RS02970
uniprot id: A0A7T1B106
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. HrtA family.
messages: Cell membrane
messages: Membrane
messages: Part of the ABC transporter complex hrt involved in hemin import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (HrtA), two transmembrane proteins (HrtB) and a solute-binding protein.

2781774:ISP08 RS01615
gene id: 2781774:ISP08_RS01615
uniprot id: A0A7T1B0T7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

2781774:ISP08 RS09120
gene id: 2781774:ISP08_RS09120
uniprot id: A0A7T1AYK4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2781774:ISP08 RS07855
gene id: 2781774:ISP08_RS07855
uniprot id: A0A7T1AY53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

2781774:ISP08 RS01960
gene id: 2781774:ISP08_RS01960
uniprot id: A0A7T1B0L7
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

2781774:ISP08 RS11390
gene id: 2781774:ISP08_RS11390
uniprot id: A0A7T1B2D5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm
messages: Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi.

2781774:ISP08 RS00325
gene id: 2781774:ISP08_RS00325
uniprot id: A0A7T1AZY6
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

2781774:ISP08 RS08300
gene id: 2781774:ISP08_RS08300
uniprot id: A0A7T1AYA2
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

2781774:ISP08 RS09150
gene id: 2781774:ISP08_RS09150
uniprot id: A0A7T1AYK7
names: Function
messages: Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.

2781774:ISP08 RS03615
gene id: 2781774:ISP08_RS03615
uniprot id: A0A7T1FA06
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

2781774:ISP08 RS09320
gene id: 2781774:ISP08_RS09320
uniprot id: A0A7T1F8U0
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

2781774:ISP08 RS10020
gene id: 2781774:ISP08_RS10020
uniprot id: A0A7T1AYX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

2781774:ISP08 RS07340
gene id: 2781774:ISP08_RS07340
uniprot id: A0A7T1AXZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

2781774:ISP08 RS09455
gene id: 2781774:ISP08_RS09455
uniprot id: A0A7T1F9F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

2781774:ISP08 RS07485
gene id: 2781774:ISP08_RS07485
uniprot id: A0A7T1F8I8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

2781774:ISP08 RS06705
gene id: 2781774:ISP08_RS06705
uniprot id: A0A7T1F8F8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm