273075:TA RS06335
gene id: 273075:TA_RS06335
uniprot id: Q9HIV2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

273075:TA RS04905
gene id: 273075:TA_RS04905
uniprot id: Q9HJL8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

273075:TA RS01105
gene id: 273075:TA_RS01105
uniprot id: Q9HLK8
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

273075:TA RS03275
gene id: 273075:TA_RS03275
uniprot id: Q9HKG3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CDC6/cdc18 family.
messages: Interacts with MCM.
messages: Involved in regulation of DNA replication. Stimulates the helicase activity of MCM via stimulation of its ATPase activity. Binding to MCM may result in conformational changes in MCM, leading to catalytic ATP hydrolysis by the helicase. Directly stimulates MCM movement along single-stranded and double-stranded DNA. Does not bind DNA.
messages: The N-terminal AAA+ ATPase domain and the C-terminal winged-helix (WH) domain are both required for stimulation of MCM activity.

273075:TA RS05365
gene id: 273075:TA_RS05365
uniprot id: Q9HJD3
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family. RadB subfamily.
messages: Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange (By similarity).

273075:TA RS00670
gene id: 273075:TA_RS00670
uniprot id: Q9HLU1
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

273075:TA RS01455
gene id: 273075:TA_RS01455
uniprot id: Q9HLE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

273075:TA RS02560
gene id: 273075:TA_RS02560
uniprot id: Q9HKV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

273075:TA RS07735
gene id: 273075:TA_RS07735
uniprot id: Q9HI54
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

273075:TA RS07325
gene id: 273075:TA_RS07325
uniprot id: Q9HI35
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

273075:TA RS01350
gene id: 273075:TA_RS01350
uniprot id: Q9HLG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

273075:TA RS00715
gene id: 273075:TA_RS00715
uniprot id: Q9HLT2
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS01230
gene id: 273075:TA_RS01230
uniprot id: Q9HLI9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm

273075:TA RS01860
gene id: 273075:TA_RS01860
uniprot id: Q9HL71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

273075:TA RS01210
gene id: 273075:TA_RS01210
uniprot id: Q9HLJ3
names: Similarity
messages: Belongs to the peptidase M20A family.

273075:TA RS05710
gene id: 273075:TA_RS05710
uniprot id: Q9HJ69
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

273075:TA RS03560
gene id: 273075:TA_RS03560
uniprot id: Q9HKB0
names: Similarity
messages: Belongs to the TPP enzyme family.

273075:TA RS07490
gene id: 273075:TA_RS07490
uniprot id: Q9HI95
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

273075:TA RS06560
gene id: 273075:TA_RS06560
uniprot id: Q9HIQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

273075:TA RS05150
gene id: 273075:TA_RS05150
uniprot id: P57706
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

273075:TA RS01225
gene id: 273075:TA_RS01225
uniprot id: Q9HLJ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

273075:TA RS05085
gene id: 273075:TA_RS05085
uniprot id: Q9HJI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

273075:TA RS05030
gene id: 273075:TA_RS05030
uniprot id: Q9HJJ3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

273075:TA RS04445
gene id: 273075:TA_RS04445
uniprot id: Q9HJV2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane

273075:TA RS04595
gene id: 273075:TA_RS04595
uniprot id: Q9HJS3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

273075:TA RS06485
gene id: 273075:TA_RS06485
uniprot id: Q9HIS2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

273075:TA RS01100
gene id: 273075:TA_RS01100
uniprot id: Q9HLK9
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnA subfamily.
messages: Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

273075:TA RS06510
gene id: 273075:TA_RS06510
uniprot id: Q9HIR8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

273075:TA RS07415
gene id: 273075:TA_RS07415
uniprot id: Q9HIB0
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

273075:TA RS06675
gene id: 273075:TA_RS06675
uniprot id: Q9HIP0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

273075:TA RS01865
gene id: 273075:TA_RS01865
uniprot id: Q9HL70
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

273075:TA RS04340
gene id: 273075:TA_RS04340
uniprot id: Q9HJX3
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS01600
gene id: 273075:TA_RS01600
uniprot id: Q9HLB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.

273075:TA RS07650
gene id: 273075:TA_RS07650
uniprot id: Q9HI67
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

273075:TA RS02960
gene id: 273075:TA_RS02960
uniprot id: Q9HKM3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

273075:TA RS05480
gene id: 273075:TA_RS05480
uniprot id: Q9HJB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

273075:TA RS06530
gene id: 273075:TA_RS06530
uniprot id: Q9HIR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

273075:TA RS05570
gene id: 273075:TA_RS05570
uniprot id: Q9HJ94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity).

273075:TA RS04785
gene id: 273075:TA_RS04785
uniprot id: Q9HJN8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

273075:TA RS00890
gene id: 273075:TA_RS00890
uniprot id: Q9HLQ1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

273075:TA RS02045
gene id: 273075:TA_RS02045
uniprot id: Q03587
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Binds 1 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is involved in DNA promoter recognition.
messages: Part of the RNA polymerase complex.

273075:TA RS01835
gene id: 273075:TA_RS01835
uniprot id: Q9HL75
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Cytoplasm
messages: Homodimer or homotetramer.

273075:TA RS00475
gene id: 273075:TA_RS00475
uniprot id: P02345
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
messages: Homotetramer.

273075:TA RS00480
gene id: 273075:TA_RS00480
uniprot id: Q9HLY0
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS04555
gene id: 273075:TA_RS04555
uniprot id: Q9HJT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

273075:TA RS07125
gene id: 273075:TA_RS07125
uniprot id: Q9HIG1
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS00050
gene id: 273075:TA_RS00050
uniprot id: Q9HM60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

273075:TA RS01665
gene id: 273075:TA_RS01665
uniprot id: Q9HLA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

273075:TA RS00465
gene id: 273075:TA_RS00465
uniprot id: Q9HLY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

273075:TA RS00520
gene id: 273075:TA_RS00520
uniprot id: Q9HLX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).

273075:TA RS05185
gene id: 273075:TA_RS05185
uniprot id: Q08717
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD.
messages: The heme is bound between the two transmembrane subunits.

273075:TA RS01170
gene id: 273075:TA_RS01170
uniprot id: Q9HLJ8
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

273075:TA RS04170
gene id: 273075:TA_RS04170
uniprot id: Q9HK01
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aldehyde dehydrogenase family. Glyceraldehyde dehydrogenase subfamily.
messages: Homotetramer. Dimer of dimers.
messages: Inhibited by calcium, cadmium, copper and mercury ions. Stable for 2 hours at 60 degrees Celsius but activity is decreased to less than 50 percent within 20 minutes at 80 degrees Celsius. Two folds activity enhancement in the presence of 1 mM glutathione, DTT, or 2-mercaptoethanol. Complete activity inhibition by thiol-modifying reagents such as p-chloromercuribenzoic acid or p-hydroxy-mercuribenzoic acid.
messages: NADP-dependent dehydrogenase of the nED (non-phosphorylated Entner-Doudoroff) pathway with highest activity towards glyceraldehydes (e.g. D,L-glyceraldehyde and D-glyceraldehyde), to a lesser extent towards D,L-glyceraldehyde-3-phosphate and glycolaldehyde, but no activity towards aliphatic or aromatic aldehydes.

273075:TA RS02705
gene id: 273075:TA_RS02705
uniprot id: Q9HKS3
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

273075:TA RS02680
gene id: 273075:TA_RS02680
uniprot id: P82853
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

273075:TA RS06160
gene id: 273075:TA_RS06160
uniprot id: Q9HIY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal long subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp (By similarity).
messages: Homodimer.

273075:TA RS04800
gene id: 273075:TA_RS04800
uniprot id: Q9HJN5
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.

273075:TA RS00385
gene id: 273075:TA_RS00385
uniprot id: Q9HLZ9
names: Similarity
messages: Belongs to the peptidase S49 family.

273075:TA RS01070
gene id: 273075:TA_RS01070
uniprot id: Q9HLL5
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

273075:TA RS00310
gene id: 273075:TA_RS00310
uniprot id: Q9HM11
names: Similarity
messages: Belongs to the PurH family.

273075:TA RS03385
gene id: 273075:TA_RS03385
uniprot id: Q9HKE5
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

273075:TA RS01470
gene id: 273075:TA_RS01470
uniprot id: Q9HLE4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

273075:TA RS03530
gene id: 273075:TA_RS03530
uniprot id: Q9HKB6
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

273075:TA RS02600
gene id: 273075:TA_RS02600
uniprot id: Q9HKU4
names: Similarity
messages: Belongs to the TPP enzyme family.

273075:TA RS06470
gene id: 273075:TA_RS06470
uniprot id: Q9HIS5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

273075:TA RS07585
gene id: 273075:TA_RS07585
uniprot id: Q9HI81
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS00020
gene id: 273075:TA_RS00020
uniprot id: Q9HM66
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

273075:TA RS01855
gene id: 273075:TA_RS01855
uniprot id: P57692
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

273075:TA RS03120
gene id: 273075:TA_RS03120
uniprot id: Q9HKJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

273075:TA RS06410
gene id: 273075:TA_RS06410
uniprot id: P57670
names: Similarity
messages: Belongs to the snRNP Sm proteins family.

273075:TA RS05980
gene id: 273075:TA_RS05980
uniprot id: Q9HJ17
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Cytoplasm
messages: Homotetramer.

273075:TA RS04220
gene id: 273075:TA_RS04220
uniprot id: Q9HJZ2
names: Similarity
messages: Belongs to the citrate synthase family.

273075:TA RS04525
gene id: 273075:TA_RS04525
uniprot id: Q9HJT6
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS02420
gene id: 273075:TA_RS02420
uniprot id: Q9HKX9
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

273075:TA RS06740
gene id: 273075:TA_RS06740
uniprot id: Q9HIN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GHMP kinase family.
messages: Catalyzes the phosphorylation of mevalonate (MVA) to yield mevalonate-3-phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3-phosphate rather than mevalonate 5-phosphate.
messages: Homodimer.

273075:TA RS03230
gene id: 273075:TA_RS03230
uniprot id: Q9HKH2
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

273075:TA RS06220
gene id: 273075:TA_RS06220
uniprot id: Q9HIX2
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

273075:TA RS03915
gene id: 273075:TA_RS03915
uniprot id: Q9HK44
names: Function
names: Miscellaneous
messages: It is proposed that Thermoplasmatales adapted the classical archaeal mevalonate pathway by replacing mevalonate 5-phosphate decarboxylase (MMD) with two specialized enzymes (mevalonate-3-phosphate 5-kinase and mevalonate 3,5-bisphosphate decarboxylase) in order to produce isoprenoids in extremely acidic environments. It was found that at low pH, the dual function enzyme MMD is unable to carry out the first phosphorylation step, yet retains its ability to perform decarboxylation.
messages: Phosphorylates mevalonate 3-phosphate to form mevalonate 3,5-bisphosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3-phosphate rather than mevalonate 5-phosphate.

273075:TA RS03190
gene id: 273075:TA_RS03190
uniprot id: Q9HKH9
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS00275
gene id: 273075:TA_RS00275
uniprot id: Q9HM18
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

273075:TA RS04120
gene id: 273075:TA_RS04120
uniprot id: Q9HK10
names: Similarity
messages: Belongs to the MCM family.

273075:TA RS00280
gene id: 273075:TA_RS00280
uniprot id: Q9HM17
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

273075:TA RS00230
gene id: 273075:TA_RS00230
uniprot id: Q9HM27
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

273075:TA RS03940
gene id: 273075:TA_RS03940
uniprot id: Q9HK40
names: Similarity
messages: Belongs to the UPF0150 family.

273075:TA RS04610
gene id: 273075:TA_RS04610
uniprot id: Q9HJS1
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the mevalonate 3,5-bisphosphate decarboxylase family.
messages: Catalyzes the ATP-independent decarboxylation of (R)-mevalonate 3,5-bisphosphate to isopentenyl phosphate. Functions in an alternative mevalonate pathway, only present in extreme acidophiles of the Thermoplasmatales order, which passes through mevalonate 3-phosphate rather than mevalonate 5-phosphate.
messages: Homodimer.
messages: It is proposed that Thermoplasmatales adapted the classical archaeal mevalonate pathway by replacing mevalonate 5-phosphate decarboxylase (MMD) with two specialized enzymes (mevalonate-3-phosphate 5-kinase and mevalonate 3,5-bisphosphate decarboxylase) in order to produce isoprenoids in extremely acidic environments. It was found that at low pH, the dual function enzyme MMD is unable to carry out the first phosphorylation step, yet retains its ability to perform decarboxylation.

273075:TA RS06450
gene id: 273075:TA_RS06450
uniprot id: Q9HIS9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

273075:TA RS02090
gene id: 273075:TA_RS02090
uniprot id: P37981
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

273075:TA RS06085
gene id: 273075:TA_RS06085
uniprot id: Q9HIZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

273075:TA RS01040
gene id: 273075:TA_RS01040
uniprot id: Q9HLM1
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

273075:TA RS02055
gene id: 273075:TA_RS02055
uniprot id: Q03586
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

273075:TA RS03410
gene id: 273075:TA_RS03410
uniprot id: Q9HKE0
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS05560
gene id: 273075:TA_RS05560
uniprot id: Q9HJ96
names: Similarity
messages: Belongs to the UDPGP type 2 family.

273075:TA RS06585
gene id: 273075:TA_RS06585
uniprot id: Q9HIQ5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

273075:TA RS05520
gene id: 273075:TA_RS05520
uniprot id: Q9HJA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

273075:TA RS05670
gene id: 273075:TA_RS05670
uniprot id: Q9HJ76
names: Similarity
messages: Belongs to the FGGY kinase family.

273075:TA RS06425
gene id: 273075:TA_RS06425
uniprot id: Q9HIT4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
messages: Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

273075:TA RS06440
gene id: 273075:TA_RS06440
uniprot id: Q9HIT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

273075:TA RS02065
gene id: 273075:TA_RS02065
uniprot id: Q03590
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).

273075:TA RS04200
gene id: 273075:TA_RS04200
uniprot id: O93655
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Part of the tricorn proteolytic complex.
messages: Proteases F1, F2 and F3 degrade oligopeptides produced by Tricorn (themselves probably produced by the proteasome), yielding free amino acids.

273075:TA RS02945
gene id: 273075:TA_RS02945
uniprot id: Q9HKM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

273075:TA RS05890
gene id: 273075:TA_RS05890
uniprot id: Q9HJ36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity).

273075:TA RS02255
gene id: 273075:TA_RS02255
uniprot id: Q9HL09
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

273075:TA RS00100
gene id: 273075:TA_RS00100
uniprot id: Q9HM50
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

273075:TA RS04530
gene id: 273075:TA_RS04530
uniprot id: Q9HJT5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

273075:TA RS05775
gene id: 273075:TA_RS05775
uniprot id: Q9HJ56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

273075:TA RS04350
gene id: 273075:TA_RS04350
uniprot id: Q9HJX2
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

273075:TA RS05370
gene id: 273075:TA_RS05370
uniprot id: Q9HJD2
names: Similarity
messages: Belongs to the peptidase M24B family.

273075:TA RS00600
gene id: 273075:TA_RS00600
uniprot id: Q9HLV6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

273075:TA RS07020
gene id: 273075:TA_RS07020
uniprot id: Q9HII2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

273075:TA RS05020
gene id: 273075:TA_RS05020
uniprot id: Q9HJJ5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

273075:TA RS00750
gene id: 273075:TA_RS00750
uniprot id: Q9HLS7
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS02115
gene id: 273075:TA_RS02115
uniprot id: Q9HL35
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
messages: Cytoplasm
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.

273075:TA RS05915
gene id: 273075:TA_RS05915
uniprot id: Q9HJ31
names: Similarity
messages: Belongs to the AOR/FOR family.

273075:TA RS01530
gene id: 273075:TA_RS01530
uniprot id: Q9HLD2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

273075:TA RS04060
gene id: 273075:TA_RS04060
uniprot id: Q9HK19
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS02660
gene id: 273075:TA_RS02660
uniprot id: Q9HKT2
names: Function
names: Miscellaneous
names: Subunit
messages: Heterodimer composed of LplA and LplB.
messages: In contrast to E.coli, where the lipoate-protein ligase is encoded by a single gene product (LplA) with a large N-terminal domain and a small C-terminal domain, the same activity in T.acidophilum is dependent on two separate proteins, corresponding to the two domains of E.coli LplA, respectively.
messages: Part of a lipoate-protein ligase complex that catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. Can also use octanoate as substrate.

273075:TA RS06265
gene id: 273075:TA_RS06265
uniprot id: Q9HIW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

273075:TA RS01460
gene id: 273075:TA_RS01460
uniprot id: Q9HLE6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

273075:TA RS04345
gene id: 273075:TA_RS04345
uniprot id: O05209
names: Similarity
names: Subunit
messages: Belongs to the AAA ATPase family. CDC48 subfamily.
messages: Homohexamer. Forms a ring-shaped particle.

273075:TA RS05545
gene id: 273075:TA_RS05545
uniprot id: Q9HJ99
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS05640
gene id: 273075:TA_RS05640
uniprot id: Q9HJ81
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

273075:TA RS03615
gene id: 273075:TA_RS03615
uniprot id: Q9HK98
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS06590
gene id: 273075:TA_RS06590
uniprot id: P48425
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Forms a Heterooligomeric complex of two stacked eight-membered rings.
messages: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.
messages: The N-terminus is blocked.

273075:TA RS00205
gene id: 273075:TA_RS00205
uniprot id: Q9HM29
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

273075:TA RS04205
gene id: 273075:TA_RS04205
uniprot id: Q9HJZ5
names: Similarity
messages: Belongs to the TPP enzyme family.

273075:TA RS01050
gene id: 273075:TA_RS01050
uniprot id: Q9HLL9
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

273075:TA RS01445
gene id: 273075:TA_RS01445
uniprot id: Q9HLE9
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

273075:TA RS06495
gene id: 273075:TA_RS06495
uniprot id: Q56230
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

273075:TA RS04590
gene id: 273075:TA_RS04590
uniprot id: Q9HJS4
names: Similarity
messages: Belongs to the transcriptional regulator TrmB family.

273075:TA RS06925
gene id: 273075:TA_RS06925
uniprot id: Q9HIJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Homodimer.
messages: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0).

273075:TA RS01560
gene id: 273075:TA_RS01560
uniprot id: Q9HLC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

273075:TA RS03850
gene id: 273075:TA_RS03850
uniprot id: Q9HK56
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

273075:TA RS05595
gene id: 273075:TA_RS05595
uniprot id: Q9HJ89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.

273075:TA RS04885
gene id: 273075:TA_RS04885
uniprot id: Q9HJM1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.

273075:TA RS06730
gene id: 273075:TA_RS06730
uniprot id: P60466
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer (By similarity).
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex (By similarity).

273075:TA RS06050
gene id: 273075:TA_RS06050
uniprot id: Q9HI35
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

273075:TA RS04245
gene id: 273075:TA_RS04245
uniprot id: Q9HJY7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Reduced FMN (FMNH(2)).

273075:TA RS00540
gene id: 273075:TA_RS00540
uniprot id: Q9HLW8
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

273075:TA RS05125
gene id: 273075:TA_RS05125
uniprot id: Q9HJH6
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS06785
gene id: 273075:TA_RS06785
uniprot id: Q9HIM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

273075:TA RS05860
gene id: 273075:TA_RS05860
uniprot id: Q9HJ42
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

273075:TA RS00090
gene id: 273075:TA_RS00090
uniprot id: Q9HM52
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

273075:TA RS06340
gene id: 273075:TA_RS06340
uniprot id: Q9HIV1
names: Similarity
messages: Belongs to the PrpD family.

273075:TA RS06765
gene id: 273075:TA_RS06765
uniprot id: P57685
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpA family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

273075:TA RS02320
gene id: 273075:TA_RS02320
uniprot id: P19486
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

273075:TA RS02050
gene id: 273075:TA_RS02050
uniprot id: Q03585
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: Part of the RNA polymerase complex.

273075:TA RS02535
gene id: 273075:TA_RS02535
uniprot id: Q9HKV6
names: Similarity
messages: Belongs to the CinA family.

273075:TA RS00625
gene id: 273075:TA_RS00625
uniprot id: Q9HLV0
names: Similarity
messages: Belongs to the glutaredoxin family.

273075:TA RS00125
gene id: 273075:TA_RS00125
uniprot id: Q9HM46
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm

273075:TA RS02440
gene id: 273075:TA_RS02440
uniprot id: Q9HKX5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

273075:TA RS06415
gene id: 273075:TA_RS06415
uniprot id: Q9HIT6
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

273075:TA RS00290
gene id: 273075:TA_RS00290
uniprot id: Q9HM15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

273075:TA RS04540
gene id: 273075:TA_RS04540
uniprot id: Q9HJT3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Can use Mg(2+) and Co(2+) with equal efficiency in vitro, and to a lesser extent, Mn(2+), but not Ni(2+).
messages: Homodimer.
messages: Nucleoside kinase with broad substrate specificity. Catalyzes the phosphorylation of a variety of nucleosides to the corresponding nucleoside 5'-mono-phosphate in the presence of phosphate donors and divalent cations. Displays the most efficient activity with guanosine, followed by inosine, cytidine, and adenosine. Negligible enzymatic activity is detected with thymidine, uridine, and 2-deoxyadenosine. ATP is the most efficient phosphate donor, but can also use GTP and ITP. Shows no sugar kinase activity, since it is unable to phosphorylate ribose, fructose-1-phosphate, or fructose-6-phosphate.

273075:TA RS04070
gene id: 273075:TA_RS04070
uniprot id: Q9HK17
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

273075:TA RS03010
gene id: 273075:TA_RS03010
uniprot id: Q9HKL4
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thermophilic archaeal actin family.
messages: Mg(2+) is required for polymerization. 4 mM MgCl(2) is sufficient to enhance the polymerization; however, higher concentrations of MgCl(2) suppresses polymerization. Polymerization is also suppressed by addition of NaCl, KCl or CaCl(2), with half suppression by about 100 mM, 10 mM and 18 mM, respectively.
messages: Polymerizes into bundles of filaments, forming a helix with a filament width of 5.5 nm and an axial repeating unit of 5.5 nm. Polymerization of Ta0583 requires NTP and is optimal with ATP, but GTP, UTP, CTP, and even the deoxy form of NTP can also support the polymerization reaction. Nucleoside diphosphate or AMP-PNP does not support polymerization.

273075:TA RS06540
gene id: 273075:TA_RS06540
uniprot id: Q9HIR3
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

273075:TA RS07065
gene id: 273075:TA_RS07065
uniprot id: Q9HIH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

273075:TA RS03500
gene id: 273075:TA_RS03500
uniprot id: Q9HKC2
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

273075:TA RS02820
gene id: 273075:TA_RS02820
uniprot id: Q9HKQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

273075:TA RS07535
gene id: 273075:TA_RS07535
uniprot id: Q9HI87
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

273075:TA RS00615
gene id: 273075:TA_RS00615
uniprot id: Q9HLV2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
messages: Cytoplasm

273075:TA RS05655
gene id: 273075:TA_RS05655
uniprot id: Q9HJ78
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS31 family.
messages: Binds 1 zinc ion per subunit.
messages: Part of the 30S ribosomal subunit.

273075:TA RS04625
gene id: 273075:TA_RS04625
uniprot id: P32044
names: Caution
names: Similarity
names: Subunit
messages: Belongs to the pyruvate kinase family.
messages: Homotetramer.
messages: PubMed:1426985 has published some partial sequence, these sequences do not originate from T.acidophilum, rather they seem to be contaminated with human samples.

273075:TA RS00315
gene id: 273075:TA_RS00315
uniprot id: Q9HM10
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

273075:TA RS07910
gene id: 273075:TA_RS07910
uniprot id: Q9HI74
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

273075:TA RS05565
gene id: 273075:TA_RS05565
uniprot id: Q9HJ95
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

273075:TA RS00795
gene id: 273075:TA_RS00795
uniprot id: Q9HLR8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

273075:TA RS03930
gene id: 273075:TA_RS03930
uniprot id: Q9HK41
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

273075:TA RS00500
gene id: 273075:TA_RS00500
uniprot id: Q9HLX6
names: Caution
names: Similarity
messages: Belongs to the peptidase S16 family.
messages: Lacks the conserved Ser-Lys catalytic dyad essential for proteolytic activity. Its enzyme activity is therefore unsure.

273075:TA RS03525
gene id: 273075:TA_RS03525
uniprot id: Q9HKB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

273075:TA RS06975
gene id: 273075:TA_RS06975
uniprot id: Q9HII9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carbamate kinase family.
messages: Cytoplasm

273075:TA RS07030
gene id: 273075:TA_RS07030
uniprot id: Q9HII0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.

273075:TA RS04490
gene id: 273075:TA_RS04490
uniprot id: Q9HJU3
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS00065
gene id: 273075:TA_RS00065
uniprot id: Q9HM56
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

273075:TA RS02850
gene id: 273075:TA_RS02850
uniprot id: P57694
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

273075:TA RS06780
gene id: 273075:TA_RS06780
uniprot id: Q9HIM6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

273075:TA RS00105
gene id: 273075:TA_RS00105
uniprot id: Q9HM49
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

273075:TA RS01475
gene id: 273075:TA_RS01475
uniprot id: Q9HLE3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm

273075:TA RS04850
gene id: 273075:TA_RS04850
uniprot id: Q9HJM7
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

273075:TA RS06195
gene id: 273075:TA_RS06195
uniprot id: Q9HIX8
names: Subcellular Location Annotation
messages: Cell membrane

273075:TA RS00025
gene id: 273075:TA_RS00025
uniprot id: Q9P997
names: Function
names: Miscellaneous
names: PTM
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.
messages: The intein interrupts the ATP-binding site.
messages: This protein undergoes a protein self splicing that involves a post-translational excision of the VDE intervening region (intein) followed by peptide ligation.

273075:TA RS06155
gene id: 273075:TA_RS06155
uniprot id: P57712
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

273075:TA RS02655
gene id: 273075:TA_RS02655
uniprot id: Q9HKT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

273075:TA RS05630
gene id: 273075:TA_RS05630
uniprot id: Q9HJ83
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

273075:TA RS05445
gene id: 273075:TA_RS05445
uniprot id: Q9HJB8
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.

273075:TA RS07390
gene id: 273075:TA_RS07390
uniprot id: Q9HIB3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

273075:TA RS05895
gene id: 273075:TA_RS05895
uniprot id: Q9HJ35
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

273075:TA RS04385
gene id: 273075:TA_RS04385
uniprot id: Q9HJW4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

273075:TA RS05755
gene id: 273075:TA_RS05755
uniprot id: Q9HJ60
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity).

273075:TA RS05360
gene id: 273075:TA_RS05360
uniprot id: Q9HJD4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity).

273075:TA RS06710
gene id: 273075:TA_RS06710
uniprot id: Q9HIN4
names: Similarity
messages: Belongs to the band 7/mec-2 family.

273075:TA RS05375
gene id: 273075:TA_RS05375
uniprot id: Q9HJD1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

273075:TA RS00015
gene id: 273075:TA_RS00015
uniprot id: Q9HM67
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

273075:TA RS06650
gene id: 273075:TA_RS06650
uniprot id: P25156
names: Activity Regulation
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The T.acidophilum proteasome is able to cleave oligopeptides after Tyr, Leu, Phe, and to a lesser extent after Glu and Arg. Thus, displays chymotrypsin-like activity and low level of caspase-like and trypsin-like activities.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The N-terminus is blocked.
messages: The configuration of the closed gate contains an opening large enough to allow rapid entry of tetrapeptides but able to impede the entry of proteins and longer peptides.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

273075:TA RS06270
gene id: 273075:TA_RS06270
uniprot id: Q9HIW4
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

273075:TA RS05695
gene id: 273075:TA_RS05695
uniprot id: Q9HJ72
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.

273075:TA RS06695
gene id: 273075:TA_RS06695
uniprot id: Q9HIN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

273075:TA RS01850
gene id: 273075:TA_RS01850
uniprot id: Q9HL72
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

273075:TA RS07045
gene id: 273075:TA_RS07045
uniprot id: Q9HIH8
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

273075:TA RS00710
gene id: 273075:TA_RS00710
uniprot id: Q9HLT3
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS01315
gene id: 273075:TA_RS01315
uniprot id: Q9HLH2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.

273075:TA RS04935
gene id: 273075:TA_RS04935
uniprot id: Q9HJL2
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

273075:TA RS05475
gene id: 273075:TA_RS05475
uniprot id: Q9HJB2
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

273075:TA RS02265
gene id: 273075:TA_RS02265
uniprot id: Q9HL07
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

273075:TA RS02315
gene id: 273075:TA_RS02315
uniprot id: Q9HKZ7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.

273075:TA RS03085
gene id: 273075:TA_RS03085
uniprot id: Q9HKK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.

273075:TA RS00265
gene id: 273075:TA_RS00265
uniprot id: Q9HM21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

273075:TA RS00190
gene id: 273075:TA_RS00190
uniprot id: Q9HM32
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

273075:TA RS05385
gene id: 273075:TA_RS05385
uniprot id: Q9HJD0
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

273075:TA RS06550
gene id: 273075:TA_RS06550
uniprot id: Q9HIR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

273075:TA RS06770
gene id: 273075:TA_RS06770
uniprot id: Q9HIM8
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

273075:TA RS04795
gene id: 273075:TA_RS04795
uniprot id: Q9HJN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

273075:TA RS07635
gene id: 273075:TA_RS07635
uniprot id: Q9HI70
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: 5'-deoxyadenosylcobalamine (coenzyme B12).
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Monomer.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

273075:TA RS03115
gene id: 273075:TA_RS03115
uniprot id: Q9HKJ4
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS03155
gene id: 273075:TA_RS03155
uniprot id: P28061
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. The T.acidophilum proteasome is able to cleave oligopeptides after Tyr, Leu, Phe, and to a lesser extent after Glu and Arg. Thus, displays chymotrypsin-like activity and low level of caspase-like and trypsin-like activities.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The configuration of the closed gate contains an opening large enough to allow rapid entry of tetrapeptides but able to impede the entry of proteins and longer peptides.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

273075:TA RS00585
gene id: 273075:TA_RS00585
uniprot id: Q9HLV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.

273075:TA RS05015
gene id: 273075:TA_RS05015
uniprot id: Q9HJJ6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

273075:TA RS04460
gene id: 273075:TA_RS04460
uniprot id: Q9HJU9
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

273075:TA RS06835
gene id: 273075:TA_RS06835
uniprot id: Q9HIL6
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

273075:TA RS04355
gene id: 273075:TA_RS04355
uniprot id: Q9HJX1
names: Similarity
messages: Belongs to the DtxR/MntR family.

273075:TA RS07440
gene id: 273075:TA_RS07440
uniprot id: Q9HIA5
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

273075:TA RS04685
gene id: 273075:TA_RS04685
uniprot id: Q9HJQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

273075:TA RS00450
gene id: 273075:TA_RS00450
uniprot id: Q9HLY6
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS01680
gene id: 273075:TA_RS01680
uniprot id: Q9HLA4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

273075:TA RS05930
gene id: 273075:TA_RS05930
uniprot id: Q9HJ28
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Although this protein is stated to be a nicotinate phosphoribosyltransferase, it has not been functionally characterized, and it might be a quinolinate phosphoribosyltransferase (QPRTase).
messages: Belongs to the NAPRTase family. Highly divergent.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Consists of three domains, an N-terminal domain, a central functional domain, and a unique C-terminal domain containing a zinc knuckle-like motif containing 4 cysteines.
messages: Homodimer. Forms a trimer of dimers in the crystal.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

273075:TA RS05765
gene id: 273075:TA_RS05765
uniprot id: Q9HJ58
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

273075:TA RS07590
gene id: 273075:TA_RS07590
uniprot id: Q9HI80
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

273075:TA RS02450
gene id: 273075:TA_RS02450
uniprot id: Q9HKX3
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS02285
gene id: 273075:TA_RS02285
uniprot id: Q9HL03
names: Similarity
messages: Belongs to the arsA ATPase family.

273075:TA RS02965
gene id: 273075:TA_RS02965
uniprot id: Q9HKM2
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

273075:TA RS03840
gene id: 273075:TA_RS03840
uniprot id: Q9HK58
names: Function
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Involved in the non-phosphorylated metabolic pathway of L-rhamnose catabolism. Catalyzes the oxidation of L-rhamnose to yield L-rhamnono-1,4-lactone. It can also oxidize L-lyxose and L-mannose, and uses only NADP.

273075:TA RS02690
gene id: 273075:TA_RS02690
uniprot id: Q9HKS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

273075:TA RS04700
gene id: 273075:TA_RS04700
uniprot id: Q9HJQ5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

273075:TA RS02530
gene id: 273075:TA_RS02530
uniprot id: Q9HKV7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.

273075:TA RS03925
gene id: 273075:TA_RS03925
uniprot id: Q9HK42
names: Similarity
messages: Belongs to the UPF0173 family.

273075:TA RS00880
gene id: 273075:TA_RS00880
uniprot id: Q9HLQ3
names: Caution
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

273075:TA RS04915
gene id: 273075:TA_RS04915
uniprot id: Q9HJL6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

273075:TA RS00595
gene id: 273075:TA_RS00595
uniprot id: P57718
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase (By similarity).

273075:TA RS03170
gene id: 273075:TA_RS03170
uniprot id: Q9HKI3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

273075:TA RS06660
gene id: 273075:TA_RS06660
uniprot id: Q9HIP3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

273075:TA RS07820
gene id: 273075:TA_RS07820
uniprot id: Q9HI38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

273075:TA RS00920
gene id: 273075:TA_RS00920
uniprot id: Q9HLP5
names: Similarity
messages: Belongs to the UPF0145 family.

273075:TA RS05440
gene id: 273075:TA_RS05440
uniprot id: Q9HJB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

273075:TA RS03770
gene id: 273075:TA_RS03770
uniprot id: Q9HK70
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS06480
gene id: 273075:TA_RS06480
uniprot id: Q9HIS3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

273075:TA RS05585
gene id: 273075:TA_RS05585
uniprot id: Q9HJ91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.

273075:TA RS04920
gene id: 273075:TA_RS04920
uniprot id: Q9HJL5
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

273075:TA RS00325
gene id: 273075:TA_RS00325
uniprot id: Q9HM08
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Binds two Mg(2+) per subunit.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

273075:TA RS05460
gene id: 273075:TA_RS05460
uniprot id: Q9HJB5
names: Similarity
messages: Belongs to the type II topoisomerase GyrB family.

273075:TA RS00590
gene id: 273075:TA_RS00590
uniprot id: Q9HLV8
names: Cofactor
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

273075:TA RS01005
gene id: 273075:TA_RS01005
uniprot id: Q9HLM8
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity).

273075:TA RS05685
gene id: 273075:TA_RS05685
uniprot id: Q9HJ74
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

273075:TA RS06635
gene id: 273075:TA_RS06635
uniprot id: P49403
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

273075:TA RS07495
gene id: 273075:TA_RS07495
uniprot id: Q9HI94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

273075:TA RS05170
gene id: 273075:TA_RS05170
uniprot id: Q9HJG7
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

273075:TA RS06790
gene id: 273075:TA_RS06790
uniprot id: Q9HIM4
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.

273075:TA RS01085
gene id: 273075:TA_RS01085
uniprot id: Q9HLL2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnC family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).

273075:TA RS05155
gene id: 273075:TA_RS05155
uniprot id: Q9HJH0
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

273075:TA RS05625
gene id: 273075:TA_RS05625
uniprot id: P50023
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

273075:TA RS07550
gene id: 273075:TA_RS07550
uniprot id: P57673
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

273075:TA RS05045
gene id: 273075:TA_RS05045
uniprot id: P57704
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal MetE family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown.

273075:TA RS04550
gene id: 273075:TA_RS04550
uniprot id: Q9HJT1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

273075:TA RS04875
gene id: 273075:TA_RS04875
uniprot id: Q9HJM3
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

273075:TA RS05255
gene id: 273075:TA_RS05255
uniprot id: Q9HJF3
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

273075:TA RS05880
gene id: 273075:TA_RS05880
uniprot id: Q9HJ37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

273075:TA RS07760
gene id: 273075:TA_RS07760
uniprot id: Q9HI47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

273075:TA RS02465
gene id: 273075:TA_RS02465
uniprot id: Q9HKX0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

273075:TA RS00525
gene id: 273075:TA_RS00525
uniprot id: Q9HLX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. Has lower activity with isopentenyl thiolophosphate (ISP). Has low activity with dimethylallyl phosphate (DMAP), 1-butyl phosphate (BP) and 3-buten-1-yl phosphate (BEP). Has no significant activity with geranyl phosphate (in vitro).
messages: Homodimer.

273075:TA RS01705
gene id: 273075:TA_RS01705
uniprot id: Q9HL99
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.

273075:TA RS06505
gene id: 273075:TA_RS06505
uniprot id: Q9HIR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

273075:TA RS06215
gene id: 273075:TA_RS06215
uniprot id: Q9HIX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

273075:TA RS02160
gene id: 273075:TA_RS02160
uniprot id: Q9HL27
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

273075:TA RS06345
gene id: 273075:TA_RS06345
uniprot id: Q9HIV0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
messages: Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.
messages: Homotetramer; dimer of dimers.
messages: Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

273075:TA RS01605
gene id: 273075:TA_RS01605
uniprot id: Q9HLB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

273075:TA RS02485
gene id: 273075:TA_RS02485
uniprot id: Q9HKW6
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.

273075:TA RS00610
gene id: 273075:TA_RS00610
uniprot id: Q9HLV3
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type N-acetylglucosamine kinase family.
messages: Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG). Is specific for KDG.
messages: Homooctamer.
messages: Probably activated by phosphorylation and inhibited by dephosphorylation.

273075:TA RS07640
gene id: 273075:TA_RS07640
uniprot id: Q9HI69
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the formiminotransferase family.
messages: Catalyzes the transfer of the formyl group from N-formylglutamate to tetrahydrofolate (THF) to yield 5-formyltetrahydrofolate (5-CHO-THF) and glutamate (Glu). The triglutamate form of 5-CHO-THF (5-CHO-THF-Glu3) can also be used as substrate. It can also catalyzes the transfer of the formimino group from N-formiminoglutamate to tetrahydrofolate (THF) to yield 5-formiminotetrahydrofolate (5-NH=CH-THF) and glutamate (Glu). It can replace YgfA to catalyzes the irreversible ATP-dependent transformation of 5-CHO-THF to form 5,10-methenyltetrahydrofolate (5,10-CH=THF).
messages: Cytoplasm

273075:TA RS04105
gene id: 273075:TA_RS04105
uniprot id: Q9HK13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

273075:TA RS06030
gene id: 273075:TA_RS06030
uniprot id: Q9HJ08
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

273075:TA RS05940
gene id: 273075:TA_RS05940
uniprot id: Q9HJ26
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

273075:TA RS00885
gene id: 273075:TA_RS00885
uniprot id: Q9HLQ2
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. Archaeal SPP-like hydrolase family.
messages: Binds 5 Mg(2+) ions per homodimer.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate. Also has significant, but less efficient, pyrophosphatase activity, since it is able to catalyze the release of phosphate from inorganic pyrophosphate (PPi).
messages: Homodimer.
messages: Inhibited by Ca(2+) ions and by high chloride ion concentration. By contrast, low chloride concentration (up to 50 mM) slightly activate the enzyme.

273075:TA RS06150
gene id: 273075:TA_RS06150
uniprot id: Q9HIY7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

273075:TA RS04450
gene id: 273075:TA_RS04450
uniprot id: Q9HJV1
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS06955
gene id: 273075:TA_RS06955
uniprot id: Q9HIJ2
names: Caution
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate mutase family.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Homodimer.
messages: Inhibited by vanadate. Inhibition can partially be relieved by EDTA.
messages: The original start site is 14 aa downstream of the start site shown here. Experiments from PubMed:17576516 were carried out with the original sequence.

273075:TA RS02610
gene id: 273075:TA_RS02610
uniprot id: Q9HKU2
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS07335
gene id: 273075:TA_RS07335
uniprot id: Q9HIC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

273075:TA RS02110
gene id: 273075:TA_RS02110
uniprot id: Q9HL36
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

273075:TA RS01555
gene id: 273075:TA_RS01555
uniprot id: O93654
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Part of the Tricorn proteolytic complex.
messages: Proteases F1, F2 and F3 degrade oligopeptides produced by Tricorn (themselves probably produced by the proteasome), yielding free amino acids.

273075:TA RS06015
gene id: 273075:TA_RS06015
uniprot id: Q9HJ11
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

273075:TA RS04000
gene id: 273075:TA_RS04000
uniprot id: Q9HK29
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

273075:TA RS02630
gene id: 273075:TA_RS02630
uniprot id: Q9HKT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

273075:TA RS03550
gene id: 273075:TA_RS03550
uniprot id: Q9HKB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

273075:TA RS01245
gene id: 273075:TA_RS01245
uniprot id: Q9HLI6
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.
messages: Cytoplasm

273075:TA RS04420
gene id: 273075:TA_RS04420
uniprot id: Q9HJV7
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS05275
gene id: 273075:TA_RS05275
uniprot id: Q9HJE9
names: Similarity
messages: Belongs to the TFIIB family.

273075:TA RS00375
gene id: 273075:TA_RS00375
uniprot id: O59635
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

273075:TA RS00635
gene id: 273075:TA_RS00635
uniprot id: Q9HLU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

273075:TA RS02040
gene id: 273075:TA_RS02040
uniprot id: Q03588
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

273075:TA RS01465
gene id: 273075:TA_RS01465
uniprot id: Q9HLE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

273075:TA RS07075
gene id: 273075:TA_RS07075
uniprot id: Q9HIH2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

273075:TA RS04410
gene id: 273075:TA_RS04410
uniprot id: Q9HJV9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

273075:TA RS07025
gene id: 273075:TA_RS07025
uniprot id: Q9HII1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

273075:TA RS01150
gene id: 273075:TA_RS01150
uniprot id: Q9HLK2
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS05540
gene id: 273075:TA_RS05540
uniprot id: Q9HJA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

273075:TA RS00420
gene id: 273075:TA_RS00420
uniprot id: Q9HLZ2
names: Similarity
messages: Belongs to the thymidylate kinase family.

273075:TA RS00700
gene id: 273075:TA_RS00700
uniprot id: Q9HLT5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDX family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Cytoplasm

273075:TA RS00570
gene id: 273075:TA_RS00570
uniprot id: Q9HLW2
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

273075:TA RS00035
gene id: 273075:TA_RS00035
uniprot id: Q9HM63
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

273075:TA RS04285
gene id: 273075:TA_RS04285
uniprot id: Q9HJY2
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

273075:TA RS05935
gene id: 273075:TA_RS05935
uniprot id: Q9HJ27
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

273075:TA RS02675
gene id: 273075:TA_RS02675
uniprot id: Q9HKS9
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Cell membrane
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. Can use both NADH and NADPH as electron donors. Also catalyzes the reduction of the naturally occurring 2,3-di-O-geranylgeranylglyceryl phosphate derivatives such as 2,3-di-O-phytyl-sn-glyceryl phosphate (DPHGP), 3-O-(2,3-di-O-phytyl-sn-glycero-phospho)-sn-glycerol (DPHGPG) and 2,3-di-O-phytyl-sn-glycero-phosphoethanolamine (DPHGPE). Is not active toward 2,3-di-O-geranylgeranylglycerol.
messages: Monomer.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

273075:TA RS01615
gene id: 273075:TA_RS01615
uniprot id: Q9HLB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

273075:TA RS02665
gene id: 273075:TA_RS02665
uniprot id: Q9HKT1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LplA family.
messages: Cytoplasm
messages: Heterodimer composed of LplA and LplB.
messages: In contrast to E.coli, where the lipoate-protein ligase is encoded by a single gene product (LplA) with a large N-terminal domain and a small C-terminal domain, the same activity in T.acidophilum is dependent on two separate proteins, corresponding to the two domains of E.coli LplA, respectively.
messages: Part of a lipoate-protein ligase complex that catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. Can also use octanoate as substrate.

273075:TA RS03355
gene id: 273075:TA_RS03355
uniprot id: Q9HKF1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

273075:TA RS05060
gene id: 273075:TA_RS05060
uniprot id: P48424
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Forms a Heterooligomeric complex of two stacked eight-membered rings.
messages: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.
messages: The N-terminus is blocked.

273075:TA RS05345
gene id: 273075:TA_RS05345
uniprot id: Q9HJD7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

273075:TA RS02085
gene id: 273075:TA_RS02085
uniprot id: Q9HL40
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

273075:TA RS01675
gene id: 273075:TA_RS01675
uniprot id: Q9HLA5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

273075:TA RS07575
gene id: 273075:TA_RS07575
uniprot id: Q9HI83
names: Similarity
messages: Belongs to the peptidase S45 family.

273075:TA RS00905
gene id: 273075:TA_RS00905
uniprot id: Q9HLP8
names: Similarity
messages: Belongs to the UPF0200 family.

273075:TA RS04825
gene id: 273075:TA_RS04825
uniprot id: Q9HJN0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

273075:TA RS04050
gene id: 273075:TA_RS04050
uniprot id: Q9HK21
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible SMC hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

273075:TA RS02950
gene id: 273075:TA_RS02950
uniprot id: Q9HKM5
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

273075:TA RS04630
gene id: 273075:TA_RS04630
uniprot id: P13203
names: Function
names: Similarity
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.
messages: Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Is also significantly active with galactose as substrate, but not with mannose or glucose 6-phosphate. Can utilize both NAD(+) and NADP(+) as electron acceptor, with a marked preference for NADP(+). Physiologically, may be involved in the degradation of both glucose and galactose through a non-phosphorylative variant of the Entner-Doudoroff pathway.
messages: Homotetramer.

273075:TA RS05760
gene id: 273075:TA_RS05760
uniprot id: Q9HJ59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

273075:TA RS06185
gene id: 273075:TA_RS06185
uniprot id: Q9HIY0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

273075:TA RS04880
gene id: 273075:TA_RS04880
uniprot id: Q9HJM2
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

273075:TA RS01515
gene id: 273075:TA_RS01515
uniprot id: Q9HLD5
names: Similarity
messages: Belongs to the thioesterase PaaI family.

273075:TA RS00270
gene id: 273075:TA_RS00270
uniprot id: Q9HM19
names: Similarity
messages: Belongs to the PDCD5 family.

273075:TA RS00650
gene id: 273075:TA_RS00650
uniprot id: Q9HLU5
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS01310
gene id: 273075:TA_RS01310
uniprot id: Q9HLH3
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

273075:TA RS04180
gene id: 273075:TA_RS04180
uniprot id: Q9HJZ9
names: Similarity
messages: Belongs to the SHMT family.

273075:TA RS03200
gene id: 273075:TA_RS03200
uniprot id: Q9HKH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

273075:TA RS02670
gene id: 273075:TA_RS02670
uniprot id: Q9HKT0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

273075:TA RS00285
gene id: 273075:TA_RS00285
uniprot id: Q9HM16
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

273075:TA RS03040
gene id: 273075:TA_RS03040
uniprot id: Q9HKK8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

273075:TA RS06685
gene id: 273075:TA_RS06685
uniprot id: Q9HIN9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

273075:TA RS06670
gene id: 273075:TA_RS06670
uniprot id: Q9HIP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

273075:TA RS06455
gene id: 273075:TA_RS06455
uniprot id: Q9HIS8
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

273075:TA RS00120
gene id: 273075:TA_RS00120
uniprot id: Q9HM47
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

273075:TA RS03450
gene id: 273075:TA_RS03450
uniprot id: Q9HKD2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

273075:TA RS02350
gene id: 273075:TA_RS02350
uniprot id: Q9HKZ3
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

273075:TA RS04865
gene id: 273075:TA_RS04865
uniprot id: Q9HJM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

273075:TA RS06005
gene id: 273075:TA_RS06005
uniprot id: Q9HJ12
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

273075:TA RS05620
gene id: 273075:TA_RS05620
uniprot id: Q9HJ84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

273075:TA RS01955
gene id: 273075:TA_RS01955
uniprot id: Q9HL57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family.
messages: Involved in the protection against polyamine toxicity by regulating their concentration. Could also be involved in the negative control of sporulation as well as production of degradative enzymes such as alpha-amylase, levansucrase and alkaline phosphatase. Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and release both CoA and the acetylated product. It can use a variety of substrates including spermidine, L-tryptophan, L-leucine, L-lysine, dopamine and tyramine.
messages: Monomer or homodimer.

273075:TA RS02230
gene id: 273075:TA_RS02230
uniprot id: Q9HL13
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS04165
gene id: 273075:TA_RS04165
uniprot id: Q9HK02
names: Similarity
messages: Belongs to the TrpC family.

273075:TA RS03995
gene id: 273075:TA_RS03995
uniprot id: Q9HK30
names: Cofactor
names: Similarity
messages: Belongs to the PdaD family.
messages: Binds 1 pyruvoyl group covalently per subunit.

273075:TA RS04955
gene id: 273075:TA_RS04955
uniprot id: Q9HJK8
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS06690
gene id: 273075:TA_RS06690
uniprot id: Q9HIN8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

273075:TA RS06855
gene id: 273075:TA_RS06855
uniprot id: Q9HIL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

273075:TA RS05990
gene id: 273075:TA_RS05990
uniprot id: Q9HJ15
names: Similarity
messages: Belongs to the UPF0179 family.

273075:TA RS02445
gene id: 273075:TA_RS02445
uniprot id: Q9HKX4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

273075:TA RS01840
gene id: 273075:TA_RS01840
uniprot id: Q9HL74
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

273075:TA RS06595
gene id: 273075:TA_RS06595
uniprot id: Q9HIQ4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

273075:TA RS01595
gene id: 273075:TA_RS01595
uniprot id: Q9HLC0
names: Similarity
messages: Belongs to the SAICAR synthetase family.

273075:TA RS04535
gene id: 273075:TA_RS04535
uniprot id: Q9HJT4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

273075:TA RS00855
gene id: 273075:TA_RS00855
uniprot id: P21553
names: Activity Regulation
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically inhibited by NADH.
messages: Belongs to the citrate synthase family.
messages: Citrate synthase is found in nearly all cells capable of oxidative metabolism.
messages: Homodimer.

273075:TA RS06500
gene id: 273075:TA_RS06500
uniprot id: P60746
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

273075:TA RS06460
gene id: 273075:TA_RS06460
uniprot id: Q9HIS7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

273075:TA RS06490
gene id: 273075:TA_RS06490
uniprot id: Q56231
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

273075:TA RS00030
gene id: 273075:TA_RS00030
uniprot id: Q9HM64
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

273075:TA RS00405
gene id: 273075:TA_RS00405
uniprot id: Q9HLZ5
names: Similarity
messages: Belongs to the UPF0284 family.

273075:TA RS04320
gene id: 273075:TA_RS04320
uniprot id: Q9HJX7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

273075:TA RS01235
gene id: 273075:TA_RS01235
uniprot id: Q9HLI8
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS02330
gene id: 273075:TA_RS02330
uniprot id: P26752
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
messages: Cytoplasm

273075:TA RS02895
gene id: 273075:TA_RS02895
uniprot id: Q9HKN7
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS06545
gene id: 273075:TA_RS06545
uniprot id: Q9HIR2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

273075:TA RS05985
gene id: 273075:TA_RS05985
uniprot id: Q9HJ16
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm

273075:TA RS06175
gene id: 273075:TA_RS06175
uniprot id: Q9HIY2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: In the C-terminal section; belongs to the YjjX NTPase family.
messages: In the N-terminal section; belongs to the eukaryotic CoaD family.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

273075:TA RS07435
gene id: 273075:TA_RS07435
uniprot id: Q9HIA6
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

273075:TA RS00010
gene id: 273075:TA_RS00010
uniprot id: Q9HM68
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

273075:TA RS05470
gene id: 273075:TA_RS05470
uniprot id: Q9HJB3
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

273075:TA RS05335
gene id: 273075:TA_RS05335
uniprot id: Q9HJD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

273075:TA RS00305
gene id: 273075:TA_RS00305
uniprot id: Q9HM12
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

273075:TA RS04765
gene id: 273075:TA_RS04765
uniprot id: Q9HJP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeosine synthase type 1 family.
messages: Forms a robust complex with the archaeosine synthase beta subunit RaSEA, likely an alpha(2)beta(2) heterotetrameric structure. Formation of this complex highly increases lysine transfer activity.
messages: Functions in the biosynthesis of archaeosine, a modified nucleoside present in the dihydrouridine loop (D-loop) of archaeal tRNAs. Catalyzes the addition of L-lysine to the cyano group of 7-cyano-7-deazaguanine (preQ0)-modified tRNAs at position 15, to generate q0kN15-tRNA, a q0N lysine adduct identified as 7-N-[(5S)-5-amino-5-carboxypentyl]formamidino-7-deazaguanosine.

273075:TA RS02925
gene id: 273075:TA_RS02925
uniprot id: Q9HKN1
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

273075:TA RS00380
gene id: 273075:TA_RS00380
uniprot id: O74110
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

273075:TA RS04680
gene id: 273075:TA_RS04680
uniprot id: Q9HJR0
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

273075:TA RS05900
gene id: 273075:TA_RS05900
uniprot id: Q9HJ34
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

273075:TA RS04890
gene id: 273075:TA_RS04890
uniprot id: Q9HJM0
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

273075:TA RS02825
gene id: 273075:TA_RS02825
uniprot id: Q9HKQ0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.

273075:TA RS05575
gene id: 273075:TA_RS05575
uniprot id: Q9HJ93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

273075:TA RS02325
gene id: 273075:TA_RS02325
uniprot id: P28079
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

273075:TA RS07720
gene id: 273075:TA_RS07720
uniprot id: P96086
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S41B family.
messages: Cytoplasm
messages: It is thought that substrate reaches the active site through the seven-bladed beta propeller channel, while products exit via the six-bladed beta propeller channel.
messages: Part of the Tricorn proteolytic complex. Assembles to form a hexameric toroid, 20 copies of which may then assemble to form an icosahedral supermolecule of 14.6 MDa.
messages: Tricorn degrades oligopeptides (probably derived from the proteasome) and channels the products to F1, F2 and F3 proteases, which then catalyze the terminal degradation step, yielding free amino acids.

273075:TA RS05510
gene id: 273075:TA_RS05510
uniprot id: Q9HJA6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).

273075:TA RS07420
gene id: 273075:TA_RS07420
uniprot id: Q9HIA9
names: Similarity
messages: Belongs to the ComB family.

273075:TA RS02905
gene id: 273075:TA_RS02905
uniprot id: Q9HKN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

273075:TA RS00460
gene id: 273075:TA_RS00460
uniprot id: Q9HLY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

273075:TA RS05235
gene id: 273075:TA_RS05235
uniprot id: Q9HJF7
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

273075:TA RS05995
gene id: 273075:TA_RS05995
uniprot id: Q9HJ14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

273075:TA RS05770
gene id: 273075:TA_RS05770
uniprot id: P57711
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

273075:TA RS02275
gene id: 273075:TA_RS02275
uniprot id: Q9HL05
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.

273075:TA RS00345
gene id: 273075:TA_RS00345
uniprot id: Q9HM04
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS00550
gene id: 273075:TA_RS00550
uniprot id: Q9HLW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

273075:TA RS06870
gene id: 273075:TA_RS06870
uniprot id: Q9HIK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.

273075:TA RS03000
gene id: 273075:TA_RS03000
uniprot id: Q9HKL5
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

273075:TA RS00070
gene id: 273075:TA_RS00070
uniprot id: Q9HM55
names: Function
names: Similarity
messages: Belongs to the type-2 OGG1 family.
messages: Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites).

273075:TA RS05825
gene id: 273075:TA_RS05825
uniprot id: Q9HJ48
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

273075:TA RS03545
gene id: 273075:TA_RS03545
uniprot id: Q9HKB3
names: Subcellular Location Annotation
messages: Membrane

273075:TA RS00215
gene id: 273075:TA_RS00215
uniprot id: Q9HM28
names: Similarity
messages: Belongs to the UPF0215 family.

273075:TA RS06205
gene id: 273075:TA_RS06205
uniprot id: Q9HIX6
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

273075:TA RS06430
gene id: 273075:TA_RS06430
uniprot id: Q9HIT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

273075:TA RS02695
gene id: 273075:TA_RS02695
uniprot id: Q9HKS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

273075:TA RS02425
gene id: 273075:TA_RS02425
uniprot id: Q9HKX8
names: Similarity
messages: Belongs to the peptidase C56 family.

273075:TA RS01205
gene id: 273075:TA_RS01205
uniprot id: Q9HLJ4
names: Similarity
messages: Belongs to the peptidase S66 family.

273075:TA RS06810
gene id: 273075:TA_RS06810
uniprot id: Q9HIM1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

273075:TA RS00505
gene id: 273075:TA_RS00505
uniprot id: Q9HLX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

273075:TA RS01220
gene id: 273075:TA_RS01220
uniprot id: Q9HLJ1
names: Similarity
messages: Belongs to the MEMO1 family.

273075:TA RS05970
gene id: 273075:TA_RS05970
uniprot id: Q9HJ19
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.