273063:STK RS04685
gene id: 273063:STK_RS04685
uniprot id: Q973Q6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

273063:STK RS06880
gene id: 273063:STK_RS06880
uniprot id: Q971Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm
messages: Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.

273063:STK RS02620
gene id: 273063:STK_RS02620
uniprot id: F9VMZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

273063:STK RS02485
gene id: 273063:STK_RS02485
uniprot id: P50455
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homotetramer.

273063:STK RS06635
gene id: 273063:STK_RS06635
uniprot id: Q972C8
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

273063:STK RS08360
gene id: 273063:STK_RS08360
uniprot id: F9VNF5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

273063:STK RS07070
gene id: 273063:STK_RS07070
uniprot id: Q971U4
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

273063:STK RS01840
gene id: 273063:STK_RS01840
uniprot id: Q975U7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

273063:STK RS00380
gene id: 273063:STK_RS00380
uniprot id: F9VMJ4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

273063:STK RS00360
gene id: 273063:STK_RS00360
uniprot id: Q976X3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

273063:STK RS02315
gene id: 273063:STK_RS02315
uniprot id: F9VMX1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M54 family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.
messages: Monomer.
messages: Probable zinc metalloprotease whose natural substrate is unknown.

273063:STK RS01045
gene id: 273063:STK_RS01045
uniprot id: Q976K2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.

273063:STK RS06620
gene id: 273063:STK_RS06620
uniprot id: F9VNX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

273063:STK RS01865
gene id: 273063:STK_RS01865
uniprot id: Q975U2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

273063:STK RS13080
gene id: 273063:STK_RS13080
uniprot id: Q96XZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

273063:STK RS06940
gene id: 273063:STK_RS06940
uniprot id: Q971X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

273063:STK RS12415
gene id: 273063:STK_RS12415
uniprot id: Q96YC2
names: Function
names: Similarity
messages: Belongs to the PGI/PMI family.
messages: Involved in the synthesis of UDP-N-acetylgalactosamine (UDP-GalNAc). Catalyzes the conversion of glucosamine-6-phosphate (GlcN-6-P) to galactosamine-6-phosphate (GalN-6-P).

273063:STK RS11950
gene id: 273063:STK_RS11950
uniprot id: Q96YL0
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

273063:STK RS05230
gene id: 273063:STK_RS05230
uniprot id: Q973F1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

273063:STK RS07665
gene id: 273063:STK_RS07665
uniprot id: Q971J1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

273063:STK RS02230
gene id: 273063:STK_RS02230
uniprot id: Q975M6
names: Similarity
messages: Belongs to the DMRL synthase family.

273063:STK RS00125
gene id: 273063:STK_RS00125
uniprot id: Q977C2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

273063:STK RS05695
gene id: 273063:STK_RS05695
uniprot id: Q972W3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

273063:STK RS07720
gene id: 273063:STK_RS07720
uniprot id: Q971H9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

273063:STK RS14470
gene id: 273063:STK_RS14470
uniprot id: F9VPJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

273063:STK RS00330
gene id: 273063:STK_RS00330
uniprot id: Q976Y0
names: Similarity
messages: Belongs to the selenium-binding protein family.

273063:STK RS10450
gene id: 273063:STK_RS10450
uniprot id: Q96ZF4
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

273063:STK RS00455
gene id: 273063:STK_RS00455
uniprot id: Q976V3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

273063:STK RS11685
gene id: 273063:STK_RS11685
uniprot id: Q96YR4
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NurA family.
messages: Homodimer (PubMed:21197557). Interacts with the single-stranded DNA-binding protein (SSB) (PubMed:18194801).
messages: Involved in DNA double-strand break (DSB) repair (By similarity). Acts probably with HerA to stimulate resection of the 5' strand and produce the long 3' single-strand that is required for RadA loading (By similarity). Exhibits both single-stranded endonuclease activity and 5'-3' exonuclease activity on single-stranded and double-stranded DNA (PubMed:18194801).
messages: The 5'-3' ssDNA and dsDNA exonuclease and ssDNA endonuclease activities are inhibited by SSB.
messages: The C-terminus is required for interaction with SSB.

273063:STK RS00155
gene id: 273063:STK_RS00155
uniprot id: Q977B4
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

273063:STK RS02555
gene id: 273063:STK_RS02555
uniprot id: Q975G6
names: Similarity
messages: Belongs to the SDO1/SBDS family.

273063:STK RS02990
gene id: 273063:STK_RS02990
uniprot id: Q974Y8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.
messages: Maximal activity at 95 Celsius degrees.

273063:STK RS06665
gene id: 273063:STK_RS06665
uniprot id: F9VNX5
names: Similarity
messages: Belongs to the GcvT family.

273063:STK RS02715
gene id: 273063:STK_RS02715
uniprot id: Q975D5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

273063:STK RS02140
gene id: 273063:STK_RS02140
uniprot id: Q975P6
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Binds two Mg(2+) per subunit.
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

273063:STK RS04430
gene id: 273063:STK_RS04430
uniprot id: Q973V2
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS12000
gene id: 273063:STK_RS12000
uniprot id: Q96YK0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.

273063:STK RS13835
gene id: 273063:STK_RS13835
uniprot id: Q96XJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

273063:STK RS02450
gene id: 273063:STK_RS02450
uniprot id: Q975I5
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

273063:STK RS03065
gene id: 273063:STK_RS03065
uniprot id: Q974X3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). Carries out the first step of the leucine biosynthesis pathway.
messages: Homodimer.

273063:STK RS10115
gene id: 273063:STK_RS10115
uniprot id: F9VNM6
names: Function
names: Similarity
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
messages: Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.

273063:STK RS01790
gene id: 273063:STK_RS01790
uniprot id: F9VMT6
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Can also use Zn(2+) or Mn(2+) in vitro, although with much less efficiency than Mg(2+).
messages: Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
messages: Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.
messages: Homooctamer; dimer of tetramers.

273063:STK RS02935
gene id: 273063:STK_RS02935
uniprot id: Q974Z9
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).

273063:STK RS04530
gene id: 273063:STK_RS04530
uniprot id: Q973T6
names: Similarity
messages: Belongs to the RutC family.

273063:STK RS06795
gene id: 273063:STK_RS06795
uniprot id: Q971Z9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

273063:STK RS04775
gene id: 273063:STK_RS04775
uniprot id: Q973P1
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS13645
gene id: 273063:STK_RS13645
uniprot id: Q96XN6
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS08220
gene id: 273063:STK_RS08220
uniprot id: Q970Y4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

273063:STK RS02350
gene id: 273063:STK_RS02350
uniprot id: Q975K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

273063:STK RS12955
gene id: 273063:STK_RS12955
uniprot id: Q96Y18
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

273063:STK RS11655
gene id: 273063:STK_RS11655
uniprot id: Q96YS0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

273063:STK RS12410
gene id: 273063:STK_RS12410
uniprot id: Q96YC3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

273063:STK RS05180
gene id: 273063:STK_RS05180
uniprot id: Q973G1
names: Function
names: Similarity
messages: Belongs to the NOP10 family.
messages: Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.

273063:STK RS14115
gene id: 273063:STK_RS14115
uniprot id: Q96XE0
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Homodimer and homotetramer.

273063:STK RS02165
gene id: 273063:STK_RS02165
uniprot id: Q975P0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

273063:STK RS02735
gene id: 273063:STK_RS02735
uniprot id: Q975D1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

273063:STK RS08290
gene id: 273063:STK_RS08290
uniprot id: Q970X1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

273063:STK RS02065
gene id: 273063:STK_RS02065
uniprot id: Q975R0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.

273063:STK RS02665
gene id: 273063:STK_RS02665
uniprot id: Q975E5
names: Function
messages: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.

273063:STK RS08535
gene id: 273063:STK_RS08535
uniprot id: Q970S3
names: Similarity
messages: Belongs to the peptidase M20A family.

273063:STK RS02550
gene id: 273063:STK_RS02550
uniprot id: Q975G7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.

273063:STK RS01740
gene id: 273063:STK_RS01740
uniprot id: Q975W6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm

273063:STK RS09695
gene id: 273063:STK_RS09695
uniprot id: F9VNK3
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS02025
gene id: 273063:STK_RS02025
uniprot id: Q975R8
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

273063:STK RS02725
gene id: 273063:STK_RS02725
uniprot id: Q975D3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

273063:STK RS12585
gene id: 273063:STK_RS12585
uniprot id: Q96Y92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.
messages: Cytoplasm

273063:STK RS05650
gene id: 273063:STK_RS05650
uniprot id: Q972X2
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS08465
gene id: 273063:STK_RS08465
uniprot id: Q970T7
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

273063:STK RS01600
gene id: 273063:STK_RS01600
uniprot id: Q975Z3
names: Similarity
messages: Belongs to the HTP reductase family.

273063:STK RS11805
gene id: 273063:STK_RS11805
uniprot id: Q96YN9
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 2 family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

273063:STK RS01935
gene id: 273063:STK_RS01935
uniprot id: Q975T0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.
messages: Cytoplasm
messages: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.

273063:STK RS02750
gene id: 273063:STK_RS02750
uniprot id: Q975C8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Monomer.
messages: Plays a role in autotrophic carbon fixation via the 3-hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the acryloyl-CoA dependent NADPH oxidation and formation of propionyl-CoA. Inactive towards 3-hydroxypropionyl-CoA, NADH and crotonyl-CoA.

273063:STK RS05350
gene id: 273063:STK_RS05350
uniprot id: Q973C8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also activates L-serine and transfers it to tRNA(Thr) but cannot deacylate incorrectly charged amino acid; unlike most archaea the editing function is found in a freestanding protein.
messages: Cytoplasm
messages: Homodimer (By similarity). Probably interacts with its editing subunit (By similarity).

273063:STK RS02480
gene id: 273063:STK_RS02480
uniprot id: Q975H9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

273063:STK RS01040
gene id: 273063:STK_RS01040
uniprot id: Q976K3
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

273063:STK RS02205
gene id: 273063:STK_RS02205
uniprot id: Q975N2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication (By similarity). The trimeric complex inhibits DNA ligase and both 3'-5' and 5'-3' activity of Hel308 (Hjm) helicase, but stimulates Hjc, the Holliday junction cleavage enzyme.
messages: The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA (By similarity). Forms a dimeric complex with PCNA3 and a trimeric complex with PCNA2 and PCNA3; does not form homotrimers (PubMed:18782564).

273063:STK RS05175
gene id: 273063:STK_RS05175
uniprot id: Q973G2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

273063:STK RS12615
gene id: 273063:STK_RS12615
uniprot id: Q96Y87
names: Similarity
messages: Belongs to the glutaredoxin family.

273063:STK RS06190
gene id: 273063:STK_RS06190
uniprot id: F9VNV5
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

273063:STK RS12570
gene id: 273063:STK_RS12570
uniprot id: Q96Y96
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm

273063:STK RS07690
gene id: 273063:STK_RS07690
uniprot id: Q971I6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

273063:STK RS01815
gene id: 273063:STK_RS01815
uniprot id: O24735
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Forms a Heterooligomeric complex of two stacked nine-membered rings; one of alpha and the other of beta subunits.
messages: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.
messages: The N-terminus is blocked.

273063:STK RS08850
gene id: 273063:STK_RS08850
uniprot id: Q970L2
names: Similarity
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily.
messages: Monomer.

273063:STK RS13565
gene id: 273063:STK_RS13565
uniprot id: Q96XQ1
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS01535
gene id: 273063:STK_RS01535
uniprot id: Q976A6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

273063:STK RS12820
gene id: 273063:STK_RS12820
uniprot id: Q96Y44
names: Similarity
messages: Belongs to the UPF0282 family.

273063:STK RS02780
gene id: 273063:STK_RS02780
uniprot id: F9VN03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Homohexamer. Dimer of a homotrimer.

273063:STK RS10155
gene id: 273063:STK_RS10155
uniprot id: Q96ZL7
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

273063:STK RS13960
gene id: 273063:STK_RS13960
uniprot id: Q96XG9
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.

273063:STK RS05625
gene id: 273063:STK_RS05625
uniprot id: Q972X7
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS00890
gene id: 273063:STK_RS00890
uniprot id: P55907
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 zinc ion.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

273063:STK RS07805
gene id: 273063:STK_RS07805
uniprot id: Q971G3
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs.

273063:STK RS04355
gene id: 273063:STK_RS04355
uniprot id: Q973W5
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Plays a role in the autotrophic CO(2) fixation pathway. Activates 3-hydroxypropionate to its CoA ester. Can also activate propionate, and to a lesser extent acrylate, acetate and butyrate.

273063:STK RS05685
gene id: 273063:STK_RS05685
uniprot id: Q972W5
names: Function
names: Similarity
messages: Belongs to the cyanase family.
messages: Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.

273063:STK RS08320
gene id: 273063:STK_RS08320
uniprot id: Q970W5
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

273063:STK RS02390
gene id: 273063:STK_RS02390
uniprot id: Q975J6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

273063:STK RS03640
gene id: 273063:STK_RS03640
uniprot id: Q974L3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

273063:STK RS04835
gene id: 273063:STK_RS04835
uniprot id: F9VNA8
names: Similarity
messages: Belongs to the WrbA family.

273063:STK RS12925
gene id: 273063:STK_RS12925
uniprot id: F9VPE1
names: Caution
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

273063:STK RS01570
gene id: 273063:STK_RS01570
uniprot id: Q975Z9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

273063:STK RS06785
gene id: 273063:STK_RS06785
uniprot id: Q972A1
names: Similarity
messages: Belongs to the TrpC family.

273063:STK RS07765
gene id: 273063:STK_RS07765
uniprot id: Q971H1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.

273063:STK RS10380
gene id: 273063:STK_RS10380
uniprot id: Q96ZG9
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

273063:STK RS06290
gene id: 273063:STK_RS06290
uniprot id: F9VNW0
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS09840
gene id: 273063:STK_RS09840
uniprot id: Q96ZS8
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS03030
gene id: 273063:STK_RS03030
uniprot id: Q974Y0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

273063:STK RS12575
gene id: 273063:STK_RS12575
uniprot id: Q96Y95
names: Similarity
messages: Belongs to the shikimate dehydrogenase family.

273063:STK RS01200
gene id: 273063:STK_RS01200
uniprot id: F9VMQ1
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

273063:STK RS08330
gene id: 273063:STK_RS08330
uniprot id: Q970W3
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.

273063:STK RS02335
gene id: 273063:STK_RS02335
uniprot id: Q975K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

273063:STK RS11465
gene id: 273063:STK_RS11465
uniprot id: Q96YV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

273063:STK RS07680
gene id: 273063:STK_RS07680
uniprot id: Q971I8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

273063:STK RS12540
gene id: 273063:STK_RS12540
uniprot id: Q96YA2
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS04630
gene id: 273063:STK_RS04630
uniprot id: Q973R6
names: Function
names: Similarity
messages: Belongs to the FAU-1 family.
messages: Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.

273063:STK RS06860
gene id: 273063:STK_RS06860
uniprot id: F9VNY7
names: Similarity
messages: Belongs to the aspartokinase family.

273063:STK RS03650
gene id: 273063:STK_RS03650
uniprot id: Q974L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

273063:STK RS05600
gene id: 273063:STK_RS05600
uniprot id: Q972Y1
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

273063:STK RS11675
gene id: 273063:STK_RS11675
uniprot id: Q96YR6
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MRE11/RAD32 family.
messages: Binds 2 manganese ions per subunit.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits (By similarity). Interacts with HerA (PubMed:18243819).
messages: Nuclease activity is regulated by Rad50.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.

273063:STK RS01130
gene id: 273063:STK_RS01130
uniprot id: F9VMP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

273063:STK RS12865
gene id: 273063:STK_RS12865
uniprot id: F9VPD8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

273063:STK RS03940
gene id: 273063:STK_RS03940
uniprot id: Q974E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

273063:STK RS08020
gene id: 273063:STK_RS08020
uniprot id: Q971C1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

273063:STK RS12920
gene id: 273063:STK_RS12920
uniprot id: Q96Y25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.

273063:STK RS11870
gene id: 273063:STK_RS11870
uniprot id: F9VP97
names: Similarity
messages: Belongs to the AP endonuclease 2 family.

273063:STK RS03155
gene id: 273063:STK_RS03155
uniprot id: Q974V5
names: Similarity
messages: Belongs to the ZPR1 family.

273063:STK RS08495
gene id: 273063:STK_RS08495
uniprot id: Q970T1
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.

273063:STK RS09370
gene id: 273063:STK_RS09370
uniprot id: Q970B4
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS01065
gene id: 273063:STK_RS01065
uniprot id: Q976J8
names: Function
names: Miscellaneous
names: PTM
names: Subunit
messages: Binds zinc ions via its zinc finger domain, as shown by X-ray crystallography (PubMed:23434852). In contrast, the absorption spectrum of the ortholog from Thermophilus suggests that it may bind iron ions, possibly via the predicted zinc finger domain.
messages: Carrier protein that bears the covalently bound substrates for arginine and lysine biosynthesis; bound L-glutamate is sequentially converted to L-ornithine, while bound alpha-aminoadipate (AAA) is sequentially converted to L-lysine.
messages: Formation of an isopeptide bond between the gamma-carboxyl group of the C-terminal glutamate and the amino group of alpha-aminoadipate (AAA) is catalyzed by LysX. The bound AAA is then converted to L-lysine in a series of reactions catalyzed by LysZ, LysY and LysJ. Release of the product L-lysine is catalyzed by LysK. Formation of an isopeptide bond between the gamma-carboxyl group of the C-terminal glutamate and the amino group of L-glutamate is catalyzed by ArgX. The bound substrate is then sequentially converted to ornithine which is eventually converted to L-arginine (PubMed:23434852).
messages: Monomer.

273063:STK RS08055
gene id: 273063:STK_RS08055
uniprot id: P62019
names: Caution
names: Similarity
names: Subunit
messages: Sul-ATPase is composed of six (or maybe five) subunits: alpha, beta, delta, gamma, C (proteolipid), and possibly epsilon.
messages: To E.hirae NtpH.
messages: Was originally reported as originating from S.acidocaldarius.

273063:STK RS07045
gene id: 273063:STK_RS07045
uniprot id: Q971V1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

273063:STK RS02400
gene id: 273063:STK_RS02400
uniprot id: Q975J4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

273063:STK RS02590
gene id: 273063:STK_RS02590
uniprot id: Q975F9
names: Activity Regulation
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Bifunctional enzyme involved in the synthesis of UDP-N-acetylglucosamine (UDP-GlcNAc) and UDP-N-acetylgalactosamine (UDP-GalNAc). It has multiple amino-sugar-1-phosphate acetyltransferase activities, including glucosamine-1-phosphate (GlcN-1-P) acetyltransferase and galactosamine-1-phosphate (GalN-1-P) acetyltransferase activities, and multiple sugar-1-phosphate nucleotidylyltransferase activities, including N-acetylglucosamine-1-phosphate (GlcNAc-1-P) uridyltransferase and N-acetylgalactosamine-1-phosphate (GalNAc-1-P) uridyltransferase activities (PubMed:15598657, PubMed:20400541, PubMed:25567746). Also catalyzes the formation of dTDP-glucose from dTTP and glucose-1-phosphate (Glc-1-P), and the reverse reaction, which produces dTTP from dTDP-glucose and diphosphate (PubMed:15598657). Can also catalyze the formation of UDP-glucose from UTP and glucose-1-phosphate (PubMed:27864169, PubMed:30291121).
messages: Can also use Mg(2+) and Zn(2+), with lower efficiency. Important for nucleotidylyltransferase activity.
messages: GlcN-1-P acetyltransferase activity is inhibited by divalent cations. GalN-1-P acetyltransferase activity is enhanced by Co(2+), Mg(2+) and Ca(2+), but inhibited by Zn(2+) or Mn(2+).
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: The C-terminal domain is essential for the formation of the trimer and the high thermostability of the entire protein. The C-terminal 11 residues are important for GalN-1-P AcTase activity, but they have an inhibitory effect on the GlcN-1-P AcTase activity.

273063:STK RS03895
gene id: 273063:STK_RS03895
uniprot id: Q974F7
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS02435
gene id: 273063:STK_RS02435
uniprot id: Q975I8
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

273063:STK RS00995
gene id: 273063:STK_RS00995
uniprot id: Q976K8
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.

273063:STK RS08190
gene id: 273063:STK_RS08190
uniprot id: Q970Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).

273063:STK RS06950
gene id: 273063:STK_RS06950
uniprot id: F9VNZ1
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase class-2 family.
messages: Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.

273063:STK RS12630
gene id: 273063:STK_RS12630
uniprot id: Q96Y84
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

273063:STK RS12965
gene id: 273063:STK_RS12965
uniprot id: Q96Y16
names: Similarity
messages: Belongs to the UDPGP type 2 family.

273063:STK RS13865
gene id: 273063:STK_RS13865
uniprot id: Q96XJ0
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS01060
gene id: 273063:STK_RS01060
uniprot id: Q976J9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RimK family. LysX subfamily.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the ATP-dependent formation of a covalent bond between the amino group of alpha-aminoadipate (AAA) and the gamma-carboxyl group of the C-terminal glutamate residue in LysW.
messages: Homodimer.

273063:STK RS03915
gene id: 273063:STK_RS03915
uniprot id: Q974F3
names: Function
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

273063:STK RS00275
gene id: 273063:STK_RS00275
uniprot id: Q976Z3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

273063:STK RS07990
gene id: 273063:STK_RS07990
uniprot id: F9VP58
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

273063:STK RS11505
gene id: 273063:STK_RS11505
uniprot id: Q96YU9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

273063:STK RS02185
gene id: 273063:STK_RS02185
uniprot id: Q975N6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CbiX family. CbiXS subfamily.
messages: Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis.
messages: Homotetramer; dimer of dimers.

273063:STK RS05250
gene id: 273063:STK_RS05250
uniprot id: Q973E7
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.
messages: Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs are marked with CCACCA and rapidly degraded.
messages: Homodimer.

273063:STK RS07560
gene id: 273063:STK_RS07560
uniprot id: Q971K9
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Heterooctamer of four alpha and four beta chains arranged as a tetramer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.
messages: Specifically catalyzes the decarboxylation of L-arginine to agmatine. Has no S-adenosylmethionine decarboxylase (AdoMetDC) activity.

273063:STK RS01565
gene id: 273063:STK_RS01565
uniprot id: Q976A0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

273063:STK RS11645
gene id: 273063:STK_RS11645
uniprot id: Q96YS2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 2 family.
messages: Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

273063:STK RS08335
gene id: 273063:STK_RS08335
uniprot id: F9VNF3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

273063:STK RS12960
gene id: 273063:STK_RS12960
uniprot id: Q96Y17
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS06125
gene id: 273063:STK_RS06125
uniprot id: Q972M6
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS01585
gene id: 273063:STK_RS01585
uniprot id: Q975Z6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

273063:STK RS10005
gene id: 273063:STK_RS10005
uniprot id: F9VNM1
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

273063:STK RS03145
gene id: 273063:STK_RS03145
uniprot id: Q974V7
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

273063:STK RS08210
gene id: 273063:STK_RS08210
uniprot id: Q970Y6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

273063:STK RS12070
gene id: 273063:STK_RS12070
uniprot id: Q96YI6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

273063:STK RS07105
gene id: 273063:STK_RS07105
uniprot id: Q971T8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity (By similarity).
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes (By similarity).
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

273063:STK RS02250
gene id: 273063:STK_RS02250
uniprot id: Q975M2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication (By similarity). Both trimeric complexes inhibit DNA ligase and both 3'-5' and 5'-3' activity of Hel308 (Hjm) helicase, but stimulate Hjc, the Holliday junction cleavage enzyme.
messages: The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA (By similarity). Forms a dimeric complex with PCNA3 and trimeric complexes PCNA123 and PCNA323; does not form homotrimers (PubMed:18782564). Crystal structures show a heterotetramer of 2 PCNA2 and 2 PCNA3, which would be large enough to clamp a Holliday junction (PubMed:21352919).

273063:STK RS01310
gene id: 273063:STK_RS01310
uniprot id: Q976E9
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

273063:STK RS08185
gene id: 273063:STK_RS08185
uniprot id: Q970Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

273063:STK RS06720
gene id: 273063:STK_RS06720
uniprot id: Q972B2
names: Similarity
messages: Belongs to the type IA topoisomerase family.

273063:STK RS11815
gene id: 273063:STK_RS11815
uniprot id: Q96YN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

273063:STK RS09995
gene id: 273063:STK_RS09995
uniprot id: F9VNM0
names: Function
names: Subunit
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

273063:STK RS07150
gene id: 273063:STK_RS07150
uniprot id: Q971T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

273063:STK RS11855
gene id: 273063:STK_RS11855
uniprot id: Q96YM7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

273063:STK RS07670
gene id: 273063:STK_RS07670
uniprot id: Q971J0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

273063:STK RS03040
gene id: 273063:STK_RS03040
uniprot id: Q974X7
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS03270
gene id: 273063:STK_RS03270
uniprot id: Q974T4
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

273063:STK RS08525
gene id: 273063:STK_RS08525
uniprot id: Q970S5
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

273063:STK RS02210
gene id: 273063:STK_RS02210
uniprot id: Q975N0
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

273063:STK RS10025
gene id: 273063:STK_RS10025
uniprot id: Q96ZP3
names: Similarity
messages: Belongs to the thioesterase PaaI family.

273063:STK RS11765
gene id: 273063:STK_RS11765
uniprot id: Q96YP8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the YjjX NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Homodimer.
messages: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

273063:STK RS10260
gene id: 273063:STK_RS10260
uniprot id: Q96ZJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NrfD family.
messages: Membrane

273063:STK RS11435
gene id: 273063:STK_RS11435
uniprot id: Q96YW3
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

273063:STK RS14490
gene id: 273063:STK_RS14490
uniprot id: Q96X69
names: Function
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

273063:STK RS08385
gene id: 273063:STK_RS08385
uniprot id: Q970V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

273063:STK RS07655
gene id: 273063:STK_RS07655
uniprot id: F9VP34
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

273063:STK RS10620
gene id: 273063:STK_RS10620
uniprot id: Q96ZC0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

273063:STK RS11625
gene id: 273063:STK_RS11625
uniprot id: F9VP86
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

273063:STK RS10120
gene id: 273063:STK_RS10120
uniprot id: Q96ZM3
names: Similarity
messages: Belongs to the PrpD family.

273063:STK RS02010
gene id: 273063:STK_RS02010
uniprot id: Q975S1
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

273063:STK RS13275
gene id: 273063:STK_RS13275
uniprot id: Q96XV7
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS01510
gene id: 273063:STK_RS01510
uniprot id: Q976B0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
messages: Part of the 30S ribosomal subunit.

273063:STK RS13990
gene id: 273063:STK_RS13990
uniprot id: Q96XG3
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

273063:STK RS08265
gene id: 273063:STK_RS08265
uniprot id: F9VNE9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

273063:STK RS12515
gene id: 273063:STK_RS12515
uniprot id: Q96YA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSL4 family.
messages: Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.

273063:STK RS13740
gene id: 273063:STK_RS13740
uniprot id: Q96XL5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

273063:STK RS11240
gene id: 273063:STK_RS11240
uniprot id: Q96Z02
names: Similarity
messages: Belongs to the esterase D family.

273063:STK RS09515
gene id: 273063:STK_RS09515
uniprot id: Q96ZY7
names: Caution
names: Function
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.
messages: Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

273063:STK RS07140
gene id: 273063:STK_RS07140
uniprot id: Q971T2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

273063:STK RS02460
gene id: 273063:STK_RS02460
uniprot id: Q975I3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

273063:STK RS02190
gene id: 273063:STK_RS02190
uniprot id: Q975N5
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

273063:STK RS13620
gene id: 273063:STK_RS13620
uniprot id: Q96XP1
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS12550
gene id: 273063:STK_RS12550
uniprot id: Q96YA0
names: Function
names: Subunit
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

273063:STK RS01350
gene id: 273063:STK_RS01350
uniprot id: Q976E1
names: Similarity
messages: Belongs to the UPF0210 family.

273063:STK RS00335
gene id: 273063:STK_RS00335
uniprot id: Q976X8
names: Similarity
messages: Belongs to the thioesterase PaaI family.

273063:STK RS12180
gene id: 273063:STK_RS12180
uniprot id: Q96YG7
names: Subcellular Location Annotation
messages: Cell membrane

273063:STK RS08980
gene id: 273063:STK_RS08980
uniprot id: Q970I8
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS11770
gene id: 273063:STK_RS11770
uniprot id: Q96YP7
names: Caution
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

273063:STK RS06730
gene id: 273063:STK_RS06730
uniprot id: F9VNX9
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

273063:STK RS04935
gene id: 273063:STK_RS04935
uniprot id: F9VNB1
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase family.
messages: Binds 1 FAD per subunit.

273063:STK RS10520
gene id: 273063:STK_RS10520
uniprot id: Q96ZD9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

273063:STK RS03580
gene id: 273063:STK_RS03580
uniprot id: Q974M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

273063:STK RS03565
gene id: 273063:STK_RS03565
uniprot id: Q974M6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sirtuin family. Class U subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.

273063:STK RS07600
gene id: 273063:STK_RS07600
uniprot id: Q971K1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

273063:STK RS09065
gene id: 273063:STK_RS09065
uniprot id: F9VNH9
names: Similarity
messages: Belongs to the HypE family.

273063:STK RS07775
gene id: 273063:STK_RS07775
uniprot id: Q971G9
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Toroid-shaped homodecamer, composed of two pentamers of five dimers.

273063:STK RS12580
gene id: 273063:STK_RS12580
uniprot id: Q96Y94
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Reduced FMN (FMNH(2)).

273063:STK RS12830
gene id: 273063:STK_RS12830
uniprot id: F9VPD7
names: Similarity
messages: Belongs to the peptidase M24B family.

273063:STK RS01195
gene id: 273063:STK_RS01195
uniprot id: Q976H4
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

273063:STK RS07970
gene id: 273063:STK_RS07970
uniprot id: Q971D0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

273063:STK RS10655
gene id: 273063:STK_RS10655
uniprot id: Q96ZB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

273063:STK RS10530
gene id: 273063:STK_RS10530
uniprot id: Q96ZD7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

273063:STK RS03970
gene id: 273063:STK_RS03970
uniprot id: P58469
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

273063:STK RS03020
gene id: 273063:STK_RS03020
uniprot id: Q974Y2
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

273063:STK RS12150
gene id: 273063:STK_RS12150
uniprot id: F9VPA8
names: Similarity
messages: Belongs to the glutamate synthase family.

273063:STK RS10105
gene id: 273063:STK_RS10105
uniprot id: Q96ZM7
names: Similarity
messages: Belongs to the citrate synthase family.

273063:STK RS08350
gene id: 273063:STK_RS08350
uniprot id: Q970V9
names: Similarity
messages: Belongs to the SAICAR synthetase family.

273063:STK RS01170
gene id: 273063:STK_RS01170
uniprot id: Q976H8
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

273063:STK RS13240
gene id: 273063:STK_RS13240
uniprot id: Q96XW4
names: Similarity
messages: Belongs to the pirin family.

273063:STK RS08470
gene id: 273063:STK_RS08470
uniprot id: F9VNG3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

273063:STK RS01295
gene id: 273063:STK_RS01295
uniprot id: Q976F3
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase 2 family.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

273063:STK RS02520
gene id: 273063:STK_RS02520
uniprot id: Q975H2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity).

273063:STK RS06805
gene id: 273063:STK_RS06805
uniprot id: Q971Z7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

273063:STK RS07650
gene id: 273063:STK_RS07650
uniprot id: Q971J4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

273063:STK RS01210
gene id: 273063:STK_RS01210
uniprot id: Q976H1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

273063:STK RS01835
gene id: 273063:STK_RS01835
uniprot id: Q975U8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

273063:STK RS11475
gene id: 273063:STK_RS11475
uniprot id: Q96YV5
names: Similarity
messages: Belongs to the UPF0047 family.

273063:STK RS02930
gene id: 273063:STK_RS02930
uniprot id: F9VN16
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

273063:STK RS12815
gene id: 273063:STK_RS12815
uniprot id: Q96Y45
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS01890
gene id: 273063:STK_RS01890
uniprot id: Q975T7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.

273063:STK RS07705
gene id: 273063:STK_RS07705
uniprot id: Q971I2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

273063:STK RS03260
gene id: 273063:STK_RS03260
uniprot id: Q974T6
names: Similarity
messages: Belongs to the RuvB family.

273063:STK RS02505
gene id: 273063:STK_RS02505
uniprot id: Q975H5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
messages: Cytoplasm

273063:STK RS12275
gene id: 273063:STK_RS12275
uniprot id: Q96YE9
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS02850
gene id: 273063:STK_RS02850
uniprot id: F9VN10
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

273063:STK RS13395
gene id: 273063:STK_RS13395
uniprot id: Q96XT4
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 Mg(2+) per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

273063:STK RS04080
gene id: 273063:STK_RS04080
uniprot id: Q974C0
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer composed of an alpha and a beta subunit.
messages: Heterodimer of the IorA and IorB subunits.

273063:STK RS02535
gene id: 273063:STK_RS02535
uniprot id: Q975H0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

273063:STK RS07965
gene id: 273063:STK_RS07965
uniprot id: F9VP56
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

273063:STK RS08015
gene id: 273063:STK_RS08015
uniprot id: Q971C2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

273063:STK RS02430
gene id: 273063:STK_RS02430
uniprot id: P60834
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

273063:STK RS07060
gene id: 273063:STK_RS07060
uniprot id: Q971U7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

273063:STK RS02465
gene id: 273063:STK_RS02465
uniprot id: Q975I2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

273063:STK RS02545
gene id: 273063:STK_RS02545
uniprot id: Q975G8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp41 subfamily.
messages: Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteromeric RNA-tails.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm

273063:STK RS12525
gene id: 273063:STK_RS12525
uniprot id: Q96YA4
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

273063:STK RS00295
gene id: 273063:STK_RS00295
uniprot id: F9VMI9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

273063:STK RS10150
gene id: 273063:STK_RS10150
uniprot id: F9VNM8
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

273063:STK RS01435
gene id: 273063:STK_RS01435
uniprot id: Q976C3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetyltransferase family. ARD1 subfamily.
messages: Cytoplasm
messages: Displays alpha (N-terminal) acetyltransferase activity. Catalyzes the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein.
messages: Homodimer.
messages: NAT does not require a binding partner for activity.

273063:STK RS09760
gene id: 273063:STK_RS09760
uniprot id: Q96ZT9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

273063:STK RS02895
gene id: 273063:STK_RS02895
uniprot id: Q975A7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

273063:STK RS01520
gene id: 273063:STK_RS01520
uniprot id: Q976A8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

273063:STK RS01735
gene id: 273063:STK_RS01735
uniprot id: Q975W7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SEC61-beta family.
messages: Cell membrane
messages: Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer (By similarity).
messages: Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex (By similarity).

273063:STK RS08740
gene id: 273063:STK_RS08740
uniprot id: Q970N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

273063:STK RS03890
gene id: 273063:STK_RS03890
uniprot id: Q974F8
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

273063:STK RS00900
gene id: 273063:STK_RS00900
uniprot id: Q976M5
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

273063:STK RS01970
gene id: 273063:STK_RS01970
uniprot id: Q975S6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.

273063:STK RS05070
gene id: 273063:STK_RS05070
uniprot id: Q973I4
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

273063:STK RS01245
gene id: 273063:STK_RS01245
uniprot id: Q976G4
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
messages: Inhibited by PCNA123 and PCNA323.

273063:STK RS04215
gene id: 273063:STK_RS04215
uniprot id: Q973Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

273063:STK RS12665
gene id: 273063:STK_RS12665
uniprot id: Q96Y77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NucS endonuclease family.
messages: Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
messages: Cytoplasm

273063:STK RS04090
gene id: 273063:STK_RS04090
uniprot id: F9VN77
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

273063:STK RS01705
gene id: 273063:STK_RS01705
uniprot id: Q975X3
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

273063:STK RS03710
gene id: 273063:STK_RS03710
uniprot id: Q974J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

273063:STK RS08045
gene id: 273063:STK_RS08045
uniprot id: Q971B6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.
messages: Sul-ATPase is composed of six (or maybe five) subunits: alpha, beta, delta, gamma, C (proteolipid), and possibly epsilon.
messages: Was originally reported as originating from S.acidocaldarius.

273063:STK RS01830
gene id: 273063:STK_RS01830
uniprot id: Q975U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

273063:STK RS12465
gene id: 273063:STK_RS12465
uniprot id: Q96YB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

273063:STK RS02420
gene id: 273063:STK_RS02420
uniprot id: Q975J0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

273063:STK RS11425
gene id: 273063:STK_RS11425
uniprot id: Q96YW5
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

273063:STK RS11295
gene id: 273063:STK_RS11295
uniprot id: Q96YZ1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DtxR/MntR family.
messages: Cytoplasm
messages: Homodimer.

273063:STK RS07940
gene id: 273063:STK_RS07940
uniprot id: Q971D4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

273063:STK RS08270
gene id: 273063:STK_RS08270
uniprot id: Q970X5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

273063:STK RS02070
gene id: 273063:STK_RS02070
uniprot id: Q975Q9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

273063:STK RS06610
gene id: 273063:STK_RS06610
uniprot id: Q972D2
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+) (PubMed:18226609, PubMed:23371294). Can also use L-asparagine, but not L-phenylalanine, L-glutamate, glycine, L-proline, L-alanine and D-aspartate (PubMed:23371294).
messages: Cytoplasm
messages: Folds into three domains: the FAD-binding domain, the capping domain and the C-terminal helical domain.
messages: Monomer.

273063:STK RS05690
gene id: 273063:STK_RS05690
uniprot id: Q972W4
names: Similarity
messages: Belongs to the UreD family.

273063:STK RS09230
gene id: 273063:STK_RS09230
uniprot id: Q970E1
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS11680
gene id: 273063:STK_RS11680
uniprot id: Q96YR5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. RAD50 subfamily.
messages: Binds 1 zinc ion per homodimer.
messages: Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.
messages: Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.
messages: The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer.

273063:STK RS02360
gene id: 273063:STK_RS02360
uniprot id: Q975K2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

273063:STK RS10135
gene id: 273063:STK_RS10135
uniprot id: Q96ZM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
messages: Cell membrane

273063:STK RS04505
gene id: 273063:STK_RS04505
uniprot id: Q973U0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

273063:STK RS10585
gene id: 273063:STK_RS10585
uniprot id: Q96ZC6
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

273063:STK RS07130
gene id: 273063:STK_RS07130
uniprot id: Q971T4
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.
messages: Monomer.

273063:STK RS06820
gene id: 273063:STK_RS06820
uniprot id: Q971Z4
names: Similarity
messages: Belongs to the acylphosphatase family.

273063:STK RS11460
gene id: 273063:STK_RS11460
uniprot id: Q96YV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

273063:STK RS03325
gene id: 273063:STK_RS03325
uniprot id: Q974S3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

273063:STK RS00925
gene id: 273063:STK_RS00925
uniprot id: Q976M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

273063:STK RS00135
gene id: 273063:STK_RS00135
uniprot id: F9VMH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

273063:STK RS02195
gene id: 273063:STK_RS02195
uniprot id: Q975N4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeal MetE family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown.

273063:STK RS06555
gene id: 273063:STK_RS06555
uniprot id: Q972E1
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS10160
gene id: 273063:STK_RS10160
uniprot id: Q96ZL5
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. Archaeal-type CbiT family.
messages: Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.

273063:STK RS10090
gene id: 273063:STK_RS10090
uniprot id: Q96ZN0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

273063:STK RS01260
gene id: 273063:STK_RS01260
uniprot id: F9VMQ7
names: Similarity
messages: Belongs to the glutaredoxin family.

273063:STK RS01055
gene id: 273063:STK_RS01055
uniprot id: Q976K0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in both the arginine and lysine biosynthetic pathways.

273063:STK RS02790
gene id: 273063:STK_RS02790
uniprot id: Q975C1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

273063:STK RS02235
gene id: 273063:STK_RS02235
uniprot id: Q975M5
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

273063:STK RS03430
gene id: 273063:STK_RS03430
uniprot id: F9VN55
names: Similarity
messages: Belongs to the HypE family.

273063:STK RS07585
gene id: 273063:STK_RS07585
uniprot id: Q971K4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

273063:STK RS08840
gene id: 273063:STK_RS08840
uniprot id: Q970L4
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS04575
gene id: 273063:STK_RS04575
uniprot id: F9VN97
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

273063:STK RS08565
gene id: 273063:STK_RS08565
uniprot id: Q970R8
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS12395
gene id: 273063:STK_RS12395
uniprot id: Q96YC6
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

273063:STK RS06825
gene id: 273063:STK_RS06825
uniprot id: Q971Z3
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

273063:STK RS10345
gene id: 273063:STK_RS10345
uniprot id: Q96ZH6
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS02375
gene id: 273063:STK_RS02375
uniprot id: Q975J9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

273063:STK RS13635
gene id: 273063:STK_RS13635
uniprot id: F9VPG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DapA family. KDPG aldolase subfamily.
messages: Homotetramer; dimer of dimers.
messages: Involved in the degradation of glucose and galactose via the Entner-Doudoroff pathway. Catalyzes the reversible cleavage of 2-keto-3-deoxy-6-phosphogluconate (KDPG) and 2-keto-3-deoxygluconate (KDG) forming pyruvate and glyceraldehyde 3-phosphate or glyceraldehyde, respectively. It is also able to catalyze the reversible cleavage of 2-keto-3-deoxy-6-phosphogalactonate (KDPGal) and 2-keto-3-deoxygalactonate (KDGal).

273063:STK RS12795
gene id: 273063:STK_RS12795
uniprot id: Q96Y49
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

273063:STK RS12930
gene id: 273063:STK_RS12930
uniprot id: Q96Y23
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

273063:STK RS05520
gene id: 273063:STK_RS05520
uniprot id: Q972Z8
names: Subcellular Location Annotation
messages: Encapsulin nanocompartment

273063:STK RS03300
gene id: 273063:STK_RS03300
uniprot id: Q974S8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

273063:STK RS10030
gene id: 273063:STK_RS10030
uniprot id: F9VNM3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

273063:STK RS05860
gene id: 273063:STK_RS05860
uniprot id: Q972S9
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

273063:STK RS04185
gene id: 273063:STK_RS04185
uniprot id: F9VN79
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Divalent metal cations; Mn(2+) and Mg(2+) are preferred over Co(2+) or Ni(2+).
messages: Monomer.
messages: Nuclease that specifically degrades the RNA of RNA-DNA hybrids. Endonucleolytically removes RNA primers from the Okazaki fragments of lagging strand synthesis on its own. In the presence of Mn(2+) or Co(2+) can also cleave an RNA-RNA hybrid; the dsRNase activity is 10- 100-fold lower than RNase H activity. Complements the temperature-sensitive phenotype of an E.coli double rnhA/rnhB (RNase H) disruption mutant.
messages: The disulfide bond confers considerable stability to the protein.
messages: The protein is hyperthermostable, melting temperature (TM) for wild-type is 102 degrees Celsius, for the double Cys mutant is 93 degrees Celsius and for a C-terminal deletion of 6 residues is 77 degrees Celsius.

273063:STK RS11905
gene id: 273063:STK_RS11905
uniprot id: Q96YL7
names: Function
names: Similarity
messages: Belongs to the THEP1 NTPase family.
messages: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.

273063:STK RS06815
gene id: 273063:STK_RS06815
uniprot id: Q971Z5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

273063:STK RS07925
gene id: 273063:STK_RS07925
uniprot id: Q971D8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

273063:STK RS00960
gene id: 273063:STK_RS00960
uniprot id: Q976L5
names: Function
names: Similarity
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.

273063:STK RS11670
gene id: 273063:STK_RS11670
uniprot id: Q96YR7
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: ATPase activity is slightly stimulated by either circular single- or double-stranded DNA with a weak preference for double-stranded DNA (PubMed:18243819). Helicase activity is stimulated by Mre11 (PubMed:18243819).
messages: Belongs to the HerA family.
messages: Forms a hexamer or a heptamer (PubMed:18243819). Interacts with Mre11 (PubMed:18243819).
messages: Involved in DNA double-strand break (DSB) repair (PubMed:18243819). Acts probably with NurA to stimulate resection of the 5' strand and produce the long 3' single-strand that is required for RadA loading (By similarity). Exhibits DNA-dependent ATPase activity and DNA helicase activity (PubMed:18243819). Loads on either a 3' or a 5' DNA tail for subsequent DNA unwinding (PubMed:18243819). Can also unwind blunt-ended dsDNA, Holliday junction and splayed-arm DNA (PubMed:18243819).

273063:STK RS12745
gene id: 273063:STK_RS12745
uniprot id: Q96Y60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Homodimer.
messages: Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.

273063:STK RS02015
gene id: 273063:STK_RS02015
uniprot id: Q975S0
names: Similarity
messages: Belongs to the SUI1 family.

273063:STK RS07675
gene id: 273063:STK_RS07675
uniprot id: Q971I9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SPT5 family.
messages: Belongs to the archaeal Spt5 family.
messages: Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).
messages: Stimulates transcription elongation.

273063:STK RS08755
gene id: 273063:STK_RS08755
uniprot id: Q970N1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

273063:STK RS02385
gene id: 273063:STK_RS02385
uniprot id: Q975J7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

273063:STK RS08550
gene id: 273063:STK_RS08550
uniprot id: F9VNG8
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

273063:STK RS08375
gene id: 273063:STK_RS08375
uniprot id: F9VNF7
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

273063:STK RS03725
gene id: 273063:STK_RS03725
uniprot id: Q974J4
names: Similarity
messages: Belongs to the peptidase U62 family.

273063:STK RS03440
gene id: 273063:STK_RS03440
uniprot id: Q974Q0
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS02440
gene id: 273063:STK_RS02440
uniprot id: Q975I7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

273063:STK RS01500
gene id: 273063:STK_RS01500
uniprot id: Q976B2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

273063:STK RS07770
gene id: 273063:STK_RS07770
uniprot id: F9VP42
names: Similarity
messages: Belongs to the peptidase M24B family.

273063:STK RS08370
gene id: 273063:STK_RS08370
uniprot id: F9VNF6
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

273063:STK RS00965
gene id: 273063:STK_RS00965
uniprot id: F9VMM8
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS08625
gene id: 273063:STK_RS08625
uniprot id: Q970Q8
names: Similarity
messages: Belongs to the thymidylate kinase family.

273063:STK RS08080
gene id: 273063:STK_RS08080
uniprot id: Q971B2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

273063:STK RS05710
gene id: 273063:STK_RS05710
uniprot id: Q972W0
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterohexamer of 3 UreC (alpha) and 3 UreAB (gamma/beta) subunits.

273063:STK RS13120
gene id: 273063:STK_RS13120
uniprot id: Q96XY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

273063:STK RS03150
gene id: 273063:STK_RS03150
uniprot id: Q974V6
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

273063:STK RS11400
gene id: 273063:STK_RS11400
uniprot id: Q96YX1
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS00410
gene id: 273063:STK_RS00410
uniprot id: Q976W3
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

273063:STK RS12915
gene id: 273063:STK_RS12915
uniprot id: F9VPE0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

273063:STK RS07595
gene id: 273063:STK_RS07595
uniprot id: Q971K2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

273063:STK RS07085
gene id: 273063:STK_RS07085
uniprot id: Q971U1
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

273063:STK RS13895
gene id: 273063:STK_RS13895
uniprot id: Q96XI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

273063:STK RS06460
gene id: 273063:STK_RS06460
uniprot id: Q972G5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S41B family.
messages: Cytoplasm
messages: Degrades oligopeptides in a sequential manner.
messages: Tricorn seems to be split into two ORFs in S.tokodaii, encoded on opposite strands and separated by approximately 279 kb.

273063:STK RS01155
gene id: 273063:STK_RS01155
uniprot id: Q976I3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.

273063:STK RS05115
gene id: 273063:STK_RS05115
uniprot id: Q973H3
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

273063:STK RS12245
gene id: 273063:STK_RS12245
uniprot id: Q96YF5
names: Similarity
messages: Belongs to the complex I subunit 3 family.

273063:STK RS06670
gene id: 273063:STK_RS06670
uniprot id: Q972C1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

273063:STK RS06970
gene id: 273063:STK_RS06970
uniprot id: Q971W5
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

273063:STK RS02995
gene id: 273063:STK_RS02995
uniprot id: Q974Y7
names: Subunit
messages: Homodimer.

273063:STK RS08620
gene id: 273063:STK_RS08620
uniprot id: F9VNH0
names: Similarity
messages: Belongs to the thymidylate kinase family.

273063:STK RS05420
gene id: 273063:STK_RS05420
uniprot id: F9VNS6
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.

273063:STK RS01095
gene id: 273063:STK_RS01095
uniprot id: F9VMN9
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

273063:STK RS01885
gene id: 273063:STK_RS01885
uniprot id: Q975T8
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

273063:STK RS05235
gene id: 273063:STK_RS05235
uniprot id: Q973F0
names: Similarity
messages: Belongs to the UPF0201 family.

273063:STK RS07565
gene id: 273063:STK_RS07565
uniprot id: Q971K8
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

273063:STK RS02500
gene id: 273063:STK_RS02500
uniprot id: Q975H6
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

273063:STK RS01530
gene id: 273063:STK_RS01530
uniprot id: P58376
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

273063:STK RS02130
gene id: 273063:STK_RS02130
uniprot id: Q975P8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

273063:STK RS12175
gene id: 273063:STK_RS12175
uniprot id: Q96YG8
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

273063:STK RS09380
gene id: 273063:STK_RS09380
uniprot id: F9VNJ5
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

273063:STK RS08560
gene id: 273063:STK_RS08560
uniprot id: F9VNG9
names: Function
names: Subunit
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

273063:STK RS08250
gene id: 273063:STK_RS08250
uniprot id: Q970X9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

273063:STK RS04650
gene id: 273063:STK_RS04650
uniprot id: Q973R2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane

273063:STK RS05090
gene id: 273063:STK_RS05090
uniprot id: Q973H9
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

273063:STK RS12905
gene id: 273063:STK_RS12905
uniprot id: Q96Y28
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

273063:STK RS12510
gene id: 273063:STK_RS12510
uniprot id: Q96YA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

273063:STK RS04895
gene id: 273063:STK_RS04895
uniprot id: Q973L6
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

273063:STK RS12710
gene id: 273063:STK_RS12710
uniprot id: Q96Y68
names: Activity Regulation
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 Mg(2+) per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.
messages: Inhibited by low concentration of 4-fluoro-7-nitrobenzofurazan (NBD-F).

273063:STK RS05990
gene id: 273063:STK_RS05990
uniprot id: Q972Q3
names: Similarity
messages: Belongs to the UPF0145 family.

273063:STK RS03530
gene id: 273063:STK_RS03530
uniprot id: Q974N3
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

273063:STK RS11255
gene id: 273063:STK_RS11255
uniprot id: Q96YZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

273063:STK RS08095
gene id: 273063:STK_RS08095
uniprot id: Q971A9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.

273063:STK RS08105
gene id: 273063:STK_RS08105
uniprot id: Q971A7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

273063:STK RS10210
gene id: 273063:STK_RS10210
uniprot id: Q96ZK3
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS03525
gene id: 273063:STK_RS03525
uniprot id: Q974N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

273063:STK RS03905
gene id: 273063:STK_RS03905
uniprot id: Q974F5
names: Similarity
messages: Belongs to the UPF0248 family.

273063:STK RS01975
gene id: 273063:STK_RS01975
uniprot id: Q975S5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Cytoplasm
messages: Homodimer or homotetramer.

273063:STK RS05355
gene id: 273063:STK_RS05355
uniprot id: Q973C7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

273063:STK RS11395
gene id: 273063:STK_RS11395
uniprot id: Q96YX2
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

273063:STK RS11450
gene id: 273063:STK_RS11450
uniprot id: Q96YW0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.
messages: X-ray crystallography in other archaea shows this protein binds a 3Fe-4S cluster, although a 4Fe-4S cluster has been suggested to be present in this protein.

273063:STK RS02020
gene id: 273063:STK_RS02020
uniprot id: Q975R9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

273063:STK RS00140
gene id: 273063:STK_RS00140
uniprot id: Q977B7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

273063:STK RS12555
gene id: 273063:STK_RS12555
uniprot id: Q96Y99
names: Function
names: Subunit
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

273063:STK RS04195
gene id: 273063:STK_RS04195
uniprot id: F9VN80
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS01635
gene id: 273063:STK_RS01635
uniprot id: Q975Y7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

273063:STK RS02175
gene id: 273063:STK_RS02175
uniprot id: Q975N8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

273063:STK RS08520
gene id: 273063:STK_RS08520
uniprot id: Q970S6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Monomer.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity). Probably catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Shows ATP hydrolysis activity in vitro, producing AMP.

273063:STK RS01080
gene id: 273063:STK_RS01080
uniprot id: Q976J5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways.

273063:STK RS03315
gene id: 273063:STK_RS03315
uniprot id: Q974S5
names: Similarity
messages: Belongs to the citrate synthase family.

273063:STK RS08125
gene id: 273063:STK_RS08125
uniprot id: Q971A3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

273063:STK RS01285
gene id: 273063:STK_RS01285
uniprot id: Q976F5
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

273063:STK RS02145
gene id: 273063:STK_RS02145
uniprot id: F9VMV9
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

273063:STK RS06220
gene id: 273063:STK_RS06220
uniprot id: Q972K9
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.

273063:STK RS08415
gene id: 273063:STK_RS08415
uniprot id: Q970U7
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

273063:STK RS06855
gene id: 273063:STK_RS06855
uniprot id: Q971Y8
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

273063:STK RS08555
gene id: 273063:STK_RS08555
uniprot id: Q970S0
names: Function
names: Subunit
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

273063:STK RS03515
gene id: 273063:STK_RS03515
uniprot id: Q974N6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

273063:STK RS02605
gene id: 273063:STK_RS02605
uniprot id: Q975F6
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

273063:STK RS06810
gene id: 273063:STK_RS06810
uniprot id: Q971Z6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

273063:STK RS08195
gene id: 273063:STK_RS08195
uniprot id: Q970Y9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

273063:STK RS02610
gene id: 273063:STK_RS02610
uniprot id: Q975F5
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

273063:STK RS12995
gene id: 273063:STK_RS12995
uniprot id: Q96Y10
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcA family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: nucleolus

273063:STK RS09225
gene id: 273063:STK_RS09225
uniprot id: Q970E2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

273063:STK RS06965
gene id: 273063:STK_RS06965
uniprot id: Q971W7
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

273063:STK RS03240
gene id: 273063:STK_RS03240
uniprot id: Q974U1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

273063:STK RS01655
gene id: 273063:STK_RS01655
uniprot id: Q975Y3
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

273063:STK RS11230
gene id: 273063:STK_RS11230
uniprot id: F9VP66
names: Subcellular Location Annotation
messages: Nucleus

273063:STK RS12260
gene id: 273063:STK_RS12260
uniprot id: F9VPB4
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS00640
gene id: 273063:STK_RS00640
uniprot id: Q976R6
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

273063:STK RS03380
gene id: 273063:STK_RS03380
uniprot id: Q974R1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

273063:STK RS07695
gene id: 273063:STK_RS07695
uniprot id: Q971I5
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

273063:STK RS01250
gene id: 273063:STK_RS01250
uniprot id: Q976G3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.

273063:STK RS04015
gene id: 273063:STK_RS04015
uniprot id: Q9HH83
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDX family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Cytoplasm
messages: Homooligomeric.
messages: Not yet known.

273063:STK RS02320
gene id: 273063:STK_RS02320
uniprot id: Q975L0
names: Function
names: Similarity
messages: Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity).
messages: Belongs to the archease family.

273063:STK RS08205
gene id: 273063:STK_RS08205
uniprot id: Q970Y7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

273063:STK RS03025
gene id: 273063:STK_RS03025
uniprot id: Q974Y1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.

273063:STK RS02410
gene id: 273063:STK_RS02410
uniprot id: Q975J2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

273063:STK RS02045
gene id: 273063:STK_RS02045
uniprot id: Q975R4
names: Similarity
messages: Belongs to the UPF0111 family.

273063:STK RS12185
gene id: 273063:STK_RS12185
uniprot id: Q96YG6
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.

273063:STK RS02395
gene id: 273063:STK_RS02395
uniprot id: Q975J5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

273063:STK RS06185
gene id: 273063:STK_RS06185
uniprot id: Q972L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

273063:STK RS00430
gene id: 273063:STK_RS00430
uniprot id: Q976V8
names: Similarity
messages: In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

273063:STK RS01545
gene id: 273063:STK_RS01545
uniprot id: Q976A4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

273063:STK RS07000
gene id: 273063:STK_RS07000
uniprot id: Q971V9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

273063:STK RS05185
gene id: 273063:STK_RS05185
uniprot id: Q973G0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-alpha family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

273063:STK RS11275
gene id: 273063:STK_RS11275
uniprot id: Q96YZ5
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.

273063:STK RS01580
gene id: 273063:STK_RS01580
uniprot id: Q975Z7
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

273063:STK RS11970
gene id: 273063:STK_RS11970
uniprot id: Q96YK6
names: Cofactor
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

273063:STK RS07065
gene id: 273063:STK_RS07065
uniprot id: Q971U6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

273063:STK RS04180
gene id: 273063:STK_RS04180
uniprot id: Q973Z9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

273063:STK RS07930
gene id: 273063:STK_RS07930
uniprot id: Q971D7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

273063:STK RS05210
gene id: 273063:STK_RS05210
uniprot id: Q973F5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication (By similarity). Both trimeric complexes inhibit DNA ligase and both 3'-5' and 5'-3' activity of Hel308 (Hjm) helicase, but stimulate Hjc, the Holliday junction cleavage enzyme.
messages: The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA (By similarity). Forms dimeric complexes with PCNA1 and PCNA2, and trimeric complexes with PCNA123 and PCNA323; does not form homotrimers (PubMed:18782564). Crystal structures show a heterotetramer of 2 PCNA2 and 2 PCNA3, which would be large enough to clamp a Holliday junction (PubMed:21352919).

273063:STK RS10795
gene id: 273063:STK_RS10795
uniprot id: Q96Z87
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

273063:STK RS14480
gene id: 273063:STK_RS14480
uniprot id: Q96X73
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

273063:STK RS02625
gene id: 273063:STK_RS02625
uniprot id: Q975F2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

273063:STK RS07975
gene id: 273063:STK_RS07975
uniprot id: Q971C9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

273063:STK RS00375
gene id: 273063:STK_RS00375
uniprot id: F9VMJ3
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

273063:STK RS02365
gene id: 273063:STK_RS02365
uniprot id: Q975K1
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

273063:STK RS03385
gene id: 273063:STK_RS03385
uniprot id: Q974R0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

273063:STK RS08410
gene id: 273063:STK_RS08410
uniprot id: Q970U8
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

273063:STK RS01725
gene id: 273063:STK_RS01725
uniprot id: F9VMT3
names: Subcellular Location Annotation
messages: Nucleus

273063:STK RS07075
gene id: 273063:STK_RS07075
uniprot id: Q971U3
names: Similarity
messages: Belongs to the CutA family.

273063:STK RS09915
gene id: 273063:STK_RS09915
uniprot id: Q96ZR4
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS06735
gene id: 273063:STK_RS06735
uniprot id: Q972A9
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

273063:STK RS00595
gene id: 273063:STK_RS00595
uniprot id: F9VMK8
names: Similarity
messages: Belongs to the malic enzymes family.

273063:STK RS03285
gene id: 273063:STK_RS03285
uniprot id: Q974T1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

273063:STK RS10930
gene id: 273063:STK_RS10930
uniprot id: Q96Z62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
messages: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
messages: Homodimer.

273063:STK RS05190
gene id: 273063:STK_RS05190
uniprot id: Q973F9
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

273063:STK RS02150
gene id: 273063:STK_RS02150
uniprot id: Q975P3
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

273063:STK RS04755
gene id: 273063:STK_RS04755
uniprot id: Q973P6
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS08010
gene id: 273063:STK_RS08010
uniprot id: Q971C3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Binds 2 Mg(2+) or Mn(2+) ions per subunit.
messages: Catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an ether-type inositol phospholipid ubiquitously distributed in archaea membranes and essential for glycolipid biosynthesis in archaea.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

273063:STK RS02340
gene id: 273063:STK_RS02340
uniprot id: Q975K6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

273063:STK RS06740
gene id: 273063:STK_RS06740
uniprot id: Q972A8
names: Function
names: Similarity
messages: Belongs to the type-2 OGG1 family.
messages: Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites).

273063:STK RS10460
gene id: 273063:STK_RS10460
uniprot id: F9VNN7
names: Similarity
messages: Belongs to the glutaredoxin family.

273063:STK RS07915
gene id: 273063:STK_RS07915
uniprot id: Q971E0
names: Similarity
messages: Belongs to the CinA family.

273063:STK RS10610
gene id: 273063:STK_RS10610
uniprot id: F9VNP2
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

273063:STK RS03280
gene id: 273063:STK_RS03280
uniprot id: F9VN40
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

273063:STK RS12715
gene id: 273063:STK_RS12715
uniprot id: Q96Y66
names: Activity Regulation
names: Domain
names: Function
names: Subunit
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.
messages: Inhibited by low concentration of 4-fluoro-7-nitrobenzofurazan (NBD-F).
messages: The Tyr-Pro-Ile-Thr-Pro (YPITP) motif is important for the turnover of the reaction, presumably through its flexibility and mobility.

273063:STK RS13460
gene id: 273063:STK_RS13460
uniprot id: Q96XS0
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

273063:STK RS06295
gene id: 273063:STK_RS06295
uniprot id: Q972J5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).

273063:STK RS06495
gene id: 273063:STK_RS06495
uniprot id: P58331
names: Cofactor
names: Function
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 zinc ion.
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

273063:STK RS11710
gene id: 273063:STK_RS11710
uniprot id: Q96YQ9
names: Similarity
messages: Belongs to the UPF0045 family.

273063:STK RS12375
gene id: 273063:STK_RS12375
uniprot id: Q96YD0
names: Function
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.
messages: Removes uracil bases that are present in DNA as a result of either deamination of cytosine or misincorporation of dUMP instead of dTMP.

273063:STK RS10125
gene id: 273063:STK_RS10125
uniprot id: P58407
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

273063:STK RS01560
gene id: 273063:STK_RS01560
uniprot id: Q976A1
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

273063:STK RS08175
gene id: 273063:STK_RS08175
uniprot id: Q970Z3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

273063:STK RS02695
gene id: 273063:STK_RS02695
uniprot id: F9VMZ7
names: Similarity
messages: Belongs to the MCM family.

273063:STK RS12595
gene id: 273063:STK_RS12595
uniprot id: Q96Y90
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.

273063:STK RS12240
gene id: 273063:STK_RS12240
uniprot id: Q96YF6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.

273063:STK RS02270
gene id: 273063:STK_RS02270
uniprot id: Q975L7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

273063:STK RS11490
gene id: 273063:STK_RS11490
uniprot id: Q96YV2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Binds two Mg(2+) per subunit.
messages: Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome.

273063:STK RS13435
gene id: 273063:STK_RS13435
uniprot id: Q96XS5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

273063:STK RS08990
gene id: 273063:STK_RS08990
uniprot id: Q970I7
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS05410
gene id: 273063:STK_RS05410
uniprot id: F9VNS5
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.

273063:STK RS00440
gene id: 273063:STK_RS00440
uniprot id: Q976V6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

273063:STK RS06800
gene id: 273063:STK_RS06800
uniprot id: F9VNY3
names: Similarity
messages: Belongs to the TrpF family.

273063:STK RS07935
gene id: 273063:STK_RS07935
uniprot id: Q971D5
names: Similarity
messages: Belongs to the UPF0173 family.

273063:STK RS05945
gene id: 273063:STK_RS05945
uniprot id: F9VNU4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Homodimer.
messages: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0).

273063:STK RS12195
gene id: 273063:STK_RS12195
uniprot id: F9VPB1
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS08430
gene id: 273063:STK_RS08430
uniprot id: F9VNG2
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

273063:STK RS10535
gene id: 273063:STK_RS10535
uniprot id: Q96ZD6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

273063:STK RS02080
gene id: 273063:STK_RS02080
uniprot id: Q975Q7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.

273063:STK RS02975
gene id: 273063:STK_RS02975
uniprot id: F9VN23
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS07710
gene id: 273063:STK_RS07710
uniprot id: Q971I1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

273063:STK RS03255
gene id: 273063:STK_RS03255
uniprot id: Q974T7
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

273063:STK RS03605
gene id: 273063:STK_RS03605
uniprot id: Q96X56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 7 kDa DNA-binding/endoribonuclease P2 family.
messages: Can constrain negative DNA supercoils. May be involved in maintaining the integrity of the genome at high temperature.
messages: Cytoplasm
messages: Monomer.

273063:STK RS02595
gene id: 273063:STK_RS02595
uniprot id: Q975F8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

273063:STK RS06915
gene id: 273063:STK_RS06915
uniprot id: O24734
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Forms a Heterooligomeric complex of two stacked nine-membered rings; one of alpha and the other of beta subunits.
messages: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity.

273063:STK RS01525
gene id: 273063:STK_RS01525
uniprot id: F9VMS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

273063:STK RS13090
gene id: 273063:STK_RS13090
uniprot id: Q96XZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

273063:STK RS02965
gene id: 273063:STK_RS02965
uniprot id: Q974Z3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

273063:STK RS02445
gene id: 273063:STK_RS02445
uniprot id: Q975I6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

273063:STK RS08200
gene id: 273063:STK_RS08200
uniprot id: Q970Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

273063:STK RS13930
gene id: 273063:STK_RS13930
uniprot id: F9VPH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

273063:STK RS10965
gene id: 273063:STK_RS10965
uniprot id: Q96Z55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRISPR system Cmr5 family.
messages: Cytoplasm

273063:STK RS13010
gene id: 273063:STK_RS13010
uniprot id: Q96Y07
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS02355
gene id: 273063:STK_RS02355
uniprot id: Q975K3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

273063:STK RS08115
gene id: 273063:STK_RS08115
uniprot id: Q971A5
names: Similarity
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.

273063:STK RS12520
gene id: 273063:STK_RS12520
uniprot id: Q96YA5
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family.
messages: Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).

273063:STK RS01430
gene id: 273063:STK_RS01430
uniprot id: F9VMR7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

273063:STK RS08060
gene id: 273063:STK_RS08060
uniprot id: P62021
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Cell membrane
messages: Sul-ATPase is composed of six (or maybe five) subunits: alpha, beta, delta, gamma, C (proteolipid), and possibly epsilon.
messages: The C chain is a proteolipid, and one of the membranous subunits of the nonenzymatic component of the Sul-ATPase complex.
messages: Was originally reported as originating from S.acidocaldarius.

273063:STK RS08355
gene id: 273063:STK_RS08355
uniprot id: F9VNF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

273063:STK RS12500
gene id: 273063:STK_RS12500
uniprot id: Q96YA8
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

273063:STK RS01550
gene id: 273063:STK_RS01550
uniprot id: Q976A3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

273063:STK RS07155
gene id: 273063:STK_RS07155
uniprot id: Q971S9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

273063:STK RS06115
gene id: 273063:STK_RS06115
uniprot id: F9VNV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

273063:STK RS07110
gene id: 273063:STK_RS07110
uniprot id: Q971T7
names: Caution
names: Cofactor
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Binds two Mg(2+) per subunit.
messages: Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.
messages: In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
messages: In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.
messages: Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
messages: Monomer.
messages: Ser-186 is present instead of the conserved Val which is part of the DDVD box.
messages: This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.

273063:STK RS02470
gene id: 273063:STK_RS02470
uniprot id: Q975I1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

273063:STK RS06985
gene id: 273063:STK_RS06985
uniprot id: Q971W2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

273063:STK RS09275
gene id: 273063:STK_RS09275
uniprot id: Q970D2
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS11285
gene id: 273063:STK_RS11285
uniprot id: Q96YZ3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycerate kinase type-1 family.
messages: Catalyzes the ATP-dependent phosphorylation of D-glycerate to 2-phosphoglycerate. It can also utilize GTP, CTP, UTP, ADP, AMP or pyrophosphate as phosphate donor.
messages: Homodimer.
messages: Magnesium. It could be replaced to some extent by nickel, manganese, cobalt, calcium, zinc or strontium.

273063:STK RS08280
gene id: 273063:STK_RS08280
uniprot id: Q970X3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

273063:STK RS04940
gene id: 273063:STK_RS04940
uniprot id: Q973K8
names: Similarity
messages: Belongs to the peptidase C56 family.

273063:STK RS08030
gene id: 273063:STK_RS08030
uniprot id: F9VNC4
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

273063:STK RS02600
gene id: 273063:STK_RS02600
uniprot id: Q975F7
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

273063:STK RS03390
gene id: 273063:STK_RS03390
uniprot id: Q974Q9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

273063:STK RS10375
gene id: 273063:STK_RS10375
uniprot id: Q96ZH0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

273063:STK RS14080
gene id: 273063:STK_RS14080
uniprot id: Q96XE7
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.

273063:STK RS12075
gene id: 273063:STK_RS12075
uniprot id: F9VPA4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

273063:STK RS01850
gene id: 273063:STK_RS01850
uniprot id: Q975U5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

273063:STK RS01505
gene id: 273063:STK_RS01505
uniprot id: Q976B1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

273063:STK RS08065
gene id: 273063:STK_RS08065
uniprot id: Q971B5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

273063:STK RS11745
gene id: 273063:STK_RS11745
uniprot id: Q96YQ2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

273063:STK RS06835
gene id: 273063:STK_RS06835
uniprot id: F9VNY5
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

273063:STK RS05195
gene id: 273063:STK_RS05195
uniprot id: Q973F8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

273063:STK RS08285
gene id: 273063:STK_RS08285
uniprot id: Q970X2
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

273063:STK RS06660
gene id: 273063:STK_RS06660
uniprot id: Q972C3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

273063:STK RS01145
gene id: 273063:STK_RS01145
uniprot id: Q976I5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL40 family.

273063:STK RS05215
gene id: 273063:STK_RS05215
uniprot id: Q973F4
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

273063:STK RS02425
gene id: 273063:STK_RS02425
uniprot id: Q975I9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

273063:STK RS09240
gene id: 273063:STK_RS09240
uniprot id: Q970D9
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

273063:STK RS03790
gene id: 273063:STK_RS03790
uniprot id: Q974I0
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

273063:STK RS01795
gene id: 273063:STK_RS01795
uniprot id: Q975V4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

273063:STK RS04370
gene id: 273063:STK_RS04370
uniprot id: Q973W2
names: Similarity
messages: Belongs to the HepT RNase toxin family.

273063:STK RS02380
gene id: 273063:STK_RS02380
uniprot id: Q975J8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

273063:STK RS10040
gene id: 273063:STK_RS10040
uniprot id: F9VNM4
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.

273063:STK RS11900
gene id: 273063:STK_RS11900
uniprot id: Q96YL8
names: Similarity
messages: Belongs to the BtpA family.

273063:STK RS07700
gene id: 273063:STK_RS07700
uniprot id: Q971I4
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

273063:STK RS06675
gene id: 273063:STK_RS06675
uniprot id: Q972C0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

273063:STK RS12855
gene id: 273063:STK_RS12855
uniprot id: Q96Y38
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

273063:STK RS02680
gene id: 273063:STK_RS02680
uniprot id: Q975E2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-archaeol synthase family.
messages: Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
messages: Cell membrane

273063:STK RS12295
gene id: 273063:STK_RS12295
uniprot id: Q96YE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity).
messages: Cytoplasm

273063:STK RS12590
gene id: 273063:STK_RS12590
uniprot id: Q96Y91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

273063:STK RS11420
gene id: 273063:STK_RS11420
uniprot id: Q96YW6
names: Similarity
messages: Belongs to the MEMO1 family.

273063:STK RS10785
gene id: 273063:STK_RS10785
uniprot id: Q96Z89
names: Function
names: Similarity
messages: Belongs to the UPF0330 family.
messages: Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC21 (Potential).

273063:STK RS00780
gene id: 273063:STK_RS00780
uniprot id: Q976P1
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS12935
gene id: 273063:STK_RS12935
uniprot id: Q96Y22
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane

273063:STK RS02160
gene id: 273063:STK_RS02160
uniprot id: Q975P1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

273063:STK RS09470
gene id: 273063:STK_RS09470
uniprot id: Q96ZZ6
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS11455
gene id: 273063:STK_RS11455
uniprot id: Q96YV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

273063:STK RS11440
gene id: 273063:STK_RS11440
uniprot id: Q96YW2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

273063:STK RS11865
gene id: 273063:STK_RS11865
uniprot id: Q96YM5
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

273063:STK RS06775
gene id: 273063:STK_RS06775
uniprot id: Q972A3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

273063:STK RS05850
gene id: 273063:STK_RS05850
uniprot id: P58432
names: Similarity
messages: Belongs to the SfsA family.

273063:STK RS02050
gene id: 273063:STK_RS02050
uniprot id: Q975R3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.
messages: Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
messages: Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers.

273063:STK RS08040
gene id: 273063:STK_RS08040
uniprot id: Q971B7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.
messages: Sul-ATPase is composed of six (or maybe five) subunits: alpha, beta, delta, gamma, C (proteolipid), and possibly epsilon.
messages: Was originally reported as originating from S.acidocaldarius.

273063:STK RS08365
gene id: 273063:STK_RS08365
uniprot id: Q970V6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

273063:STK RS14495
gene id: 273063:STK_RS14495
uniprot id: Q96X68
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas5 family. Subtype I-A/Apern subfamily.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

273063:STK RS01165
gene id: 273063:STK_RS01165
uniprot id: Q976I0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTH2 family.
messages: Cytoplasm
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

273063:STK RS07175
gene id: 273063:STK_RS07175
uniprot id: Q971S6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.

273063:STK RS11845
gene id: 273063:STK_RS11845
uniprot id: Q96YM9
names: Similarity
messages: Belongs to the UPF0284 family.

273063:STK RS14370
gene id: 273063:STK_RS14370
uniprot id: Q96X90
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

273063:STK RS02560
gene id: 273063:STK_RS02560
uniprot id: Q975G5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

273063:STK RS01345
gene id: 273063:STK_RS01345
uniprot id: F9VMR2
names: Similarity
messages: Belongs to the UPF0237 family.

273063:STK RS01050
gene id: 273063:STK_RS01050
uniprot id: Q976K1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family. LysK subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.
messages: Cytoplasm

273063:STK RS00575
gene id: 273063:STK_RS00575
uniprot id: F9VMK7
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS01335
gene id: 273063:STK_RS01335
uniprot id: Q976E4
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Involved in the synthesis of UDP-N-acetylglucosamine (UDP-GlcNAc) and UDP-N-acetylgalactosamine (UDP-GalNAc). Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate and of galactosamine-6-phosphate to galactosamine-1-phosphate.

273063:STK RS02455
gene id: 273063:STK_RS02455
uniprot id: Q975I4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

273063:STK RS03335
gene id: 273063:STK_RS03335
uniprot id: Q974S1
names: Activity Regulation
names: Domain
names: Function
names: Similarity
names: Subunit
messages: An ATP, Mg(2+)-dependent DNA 3'-5' and 5'-3' helicase that may be involved in repair of stalled replication forks. Stimulated by both ss and dsDNA. Unwinds both leading and lagging strands in replication fork structures, unlike orthologs in P. furiosus and M. thermautotrophicus which only unwind the lagging strand and only have 3'-5' helicase activity. Preferentially binds dsDNA with overhangs or branched DNA. Able to anneal DNA substrates that could form a replication fork-like structure, has replication fork reversal activity (at least in vitro).
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-binding occurs via the first 2 N-terminal domains, which are also responsible for ATPase.
messages: Helicase activity is inhibited by Hjc (PubMed:18296528) and by PCNA123 and PCNA323 (PubMed:18782564).
messages: Monomer; forms a 1:2 complex with Hjc, which may form a complex with Holliday junction DNA.
messages: The C-terminal region (646-704) inhibits ATPase and helicase activity.
messages: The central region (432-645) which is structurally composed of 2 domains (432-500 and 501-645) is necessary for helicase activity.

273063:STK RS02415
gene id: 273063:STK_RS02415
uniprot id: Q975J1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

273063:STK RS03360
gene id: 273063:STK_RS03360
uniprot id: F9VN48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

273063:STK RS07785
gene id: 273063:STK_RS07785
uniprot id: F9VP44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

273063:STK RS11405
gene id: 273063:STK_RS11405
uniprot id: F9VP77
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

273063:STK RS08180
gene id: 273063:STK_RS08180
uniprot id: Q970Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

273063:STK RS02660
gene id: 273063:STK_RS02660
uniprot id: Q975E6
names: Similarity
messages: Belongs to the thymidylate kinase family.

273063:STK RS11390
gene id: 273063:STK_RS11390
uniprot id: Q96YX3
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

273063:STK RS14475
gene id: 273063:STK_RS14475
uniprot id: F9VPJ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

273063:STK RS01070
gene id: 273063:STK_RS01070
uniprot id: Q976J7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homotetramer.
messages: In the absence or at low concentrations of lysine, activates the biosynthesis of this amino acid via the alpha-aminoadipate (AAA) pathway.

273063:STK RS02650
gene id: 273063:STK_RS02650
uniprot id: Q975E9
names: Similarity
messages: Belongs to the UPF0147 family.

273063:STK RS06695
gene id: 273063:STK_RS06695
uniprot id: Q972B6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

273063:STK RS09550
gene id: 273063:STK_RS09550
uniprot id: Q96ZY0
names: Similarity
messages: Belongs to the AAA ATPase family.

273063:STK RS09045
gene id: 273063:STK_RS09045
uniprot id: Q970H8
names: Similarity
messages: Belongs to the pyruvate kinase family.

273063:STK RS04700
gene id: 273063:STK_RS04700
uniprot id: Q973Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

273063:STK RS11965
gene id: 273063:STK_RS11965
uniprot id: Q96YK7
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

273063:STK RS02540
gene id: 273063:STK_RS02540
uniprot id: Q975G9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase PH family. Rrp42 subfamily.
messages: Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.
messages: Cytoplasm
messages: Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.

273063:STK RS11430
gene id: 273063:STK_RS11430
uniprot id: Q96YW4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

273063:STK RS12205
gene id: 273063:STK_RS12205
uniprot id: Q96YG3
names: Similarity
messages: Belongs to the band 7/mec-2 family.

273063:STK RS06375
gene id: 273063:STK_RS06375
uniprot id: Q972I2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Binds 1 heme group per subunit.
messages: Cytoplasm

273063:STK RS06780
gene id: 273063:STK_RS06780
uniprot id: Q972A2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Cytoplasm
messages: Homodimer.

273063:STK RS05010
gene id: 273063:STK_RS05010
uniprot id: Q973J4
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS01575
gene id: 273063:STK_RS01575
uniprot id: Q975Z8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

273063:STK RS11495
gene id: 273063:STK_RS11495
uniprot id: F9VP80
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

273063:STK RS13870
gene id: 273063:STK_RS13870
uniprot id: F9VPH0
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

273063:STK RS10205
gene id: 273063:STK_RS10205
uniprot id: Q96ZK5
names: Similarity
messages: Belongs to the UPF0273 family.

273063:STK RS13270
gene id: 273063:STK_RS13270
uniprot id: Q96XV8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family.
messages: Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as 2-oxoglutarate, pyruvate and 2-oxobutyrate to form their CoA derivatives.
messages: Heterodimer composed of an alpha and a beta subunit.

273063:STK RS04300
gene id: 273063:STK_RS04300
uniprot id: Q973X5
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

273063:STK RS01960
gene id: 273063:STK_RS01960
uniprot id: P58460
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm
messages: Homodimer.

273063:STK RS02240
gene id: 273063:STK_RS02240
uniprot id: Q975M4
names: Function
names: Similarity
messages: Belongs to the archaeal-type GTP cyclohydrolase family.
messages: Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.

273063:STK RS13195
gene id: 273063:STK_RS13195
uniprot id: Q96XX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

273063:STK RS02580
gene id: 273063:STK_RS02580
uniprot id: Q975G1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

273063:STK RS14065
gene id: 273063:STK_RS14065
uniprot id: F9VPH9
names: Function
messages: Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.

273063:STK RS11445
gene id: 273063:STK_RS11445
uniprot id: Q96YW1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

273063:STK RS01625
gene id: 273063:STK_RS01625
uniprot id: Q975Y9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.

273063:STK RS07135
gene id: 273063:STK_RS07135
uniprot id: Q971T3
names: Function
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.
messages: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.

273063:STK RS08090
gene id: 273063:STK_RS08090
uniprot id: F9VND5
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products. Inhibits the helicase activity of Hel308 (Hjm).
messages: Belongs to the Holliday junction resolvase Hjc family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cleavage stimulated by PCNA123 and PCNA323 (PubMed:18782564) and by RadC2 (PubMed:22437993).
messages: Homodimer; forms a 2:1 complex with Hel308 (Hjm). May form a complex with Holliday junction DNA, Hjc and Hjm.

273063:STK RS00555
gene id: 273063:STK_RS00555
uniprot id: F9VMK5
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 2 family.

273063:STK RS07145
gene id: 273063:STK_RS07145
uniprot id: Q971T1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

273063:STK RS03250
gene id: 273063:STK_RS03250
uniprot id: Q974T8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.

273063:STK RS11610
gene id: 273063:STK_RS11610
uniprot id: Q96X56
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 7 kDa DNA-binding/endoribonuclease P2 family.
messages: Can constrain negative DNA supercoils. May be involved in maintaining the integrity of the genome at high temperature.
messages: Cytoplasm
messages: Monomer.

273063:STK RS04500
gene id: 273063:STK_RS04500
uniprot id: Q973U1
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

273063:STK RS06165
gene id: 273063:STK_RS06165
uniprot id: Q972L8
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

273063:STK RS13630
gene id: 273063:STK_RS13630
uniprot id: Q96XN9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Homotetramer.
messages: Involved in the degradation of glucose via the semi-phosphorylative Entner-Doudoroff pathway. Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG). Can also use GTP, but not ADP or AMP, as a phosphoryl donor and 2-keto-D-gluconate (KG) as a phosphoryl acceptor.
messages: Mg(2+) is the most effective ion, but it can be replaced with Co(2+), Ni(2+), Zn(2+) or Mn(2+).

273063:STK RS12365
gene id: 273063:STK_RS12365
uniprot id: Q96YD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

273063:STK RS01540
gene id: 273063:STK_RS01540
uniprot id: F9VMS2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

273063:STK RS08400
gene id: 273063:STK_RS08400
uniprot id: Q970V0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

273063:STK RS06425
gene id: 273063:STK_RS06425
uniprot id: Q972H0
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.

273063:STK RS05220
gene id: 273063:STK_RS05220
uniprot id: Q973F3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

273063:STK RS07115
gene id: 273063:STK_RS07115
uniprot id: Q971T6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity (By similarity).
messages: Belongs to the histone-like Alba family.
messages: Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes (By similarity).
messages: Chromosome
messages: Cytoplasm
messages: Homotetramer.

273063:STK RS14175
gene id: 273063:STK_RS14175
uniprot id: F9VPI2
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

273063:STK RS13410
gene id: 273063:STK_RS13410
uniprot id: Q96XS9
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS07820
gene id: 273063:STK_RS07820
uniprot id: Q971G0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerA subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

273063:STK RS02370
gene id: 273063:STK_RS02370
uniprot id: Q975K0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

273063:STK RS11225
gene id: 273063:STK_RS11225
uniprot id: F9VP65
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.

273063:STK RS02180
gene id: 273063:STK_RS02180
uniprot id: Q975N7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

273063:STK RS08420
gene id: 273063:STK_RS08420
uniprot id: Q970U6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RimK family. LysX subfamily.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the ATP-dependent formation of a covalent bond between the amino group of glutamate and the gamma-carboxyl group of the C-terminal glutamate residue in LysW.
messages: Homotetramer. Interacts with LysW.

273063:STK RS01075
gene id: 273063:STK_RS01075
uniprot id: Q976J6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. LysZ subfamily.
messages: Cytoplasm
messages: Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).

273063:STK RS07580
gene id: 273063:STK_RS07580
uniprot id: F9VP30
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

273063:STK RS05490
gene id: 273063:STK_RS05490
uniprot id: Q973A3
names: Caution
names: Function
names: Similarity
messages: Belongs to the Nre family.
messages: Involved in DNA damage repair.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

273063:STK RS11785
gene id: 273063:STK_RS11785
uniprot id: Q96YP4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.
messages: Homodimer.
messages: Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.

273063:STK RS03095
gene id: 273063:STK_RS03095
uniprot id: F9VN30
names: Cofactor
messages: Binds 1 zinc ion per subunit.

273063:STK RS01965
gene id: 273063:STK_RS01965
uniprot id: Q975S7
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

273063:STK RS02090
gene id: 273063:STK_RS02090
uniprot id: F9VMV5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

273063:STK RS02720
gene id: 273063:STK_RS02720
uniprot id: Q975D4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcL subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

273063:STK RS09685
gene id: 273063:STK_RS09685
uniprot id: Q96ZV1
names: Subcellular Location Annotation
messages: Membrane

273063:STK RS03845
gene id: 273063:STK_RS03845
uniprot id: Q974G8
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

273063:STK RS08050
gene id: 273063:STK_RS08050
uniprot id: P62017
names: Caution
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.
messages: Sul-ATPase is composed of six (or maybe five) subunits: alpha, beta, delta, gamma, C (proteolipid), and possibly epsilon.
messages: The N-terminus is blocked.
messages: Was originally reported as originating from S.acidocaldarius.