27291:SPAR D05300
gene id: 27291:SPAR_D05300
uniprot id: A0A8B8UP78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

27291:SPAR M02420
gene id: 27291:SPAR_M02420
uniprot id: A0A8B8UXD0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DLT1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Required for growth under high-pressure and low-temperature conditions.

27291:SPAR E00110
gene id: 27291:SPAR_E00110
uniprot id: A0A8B8UPR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Vacuole membrane

27291:SPAR M02060
gene id: 27291:SPAR_M02060
uniprot id: A0A8B8UXE1
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

27291:SPAR L00290
gene id: 27291:SPAR_L00290
uniprot id: A0A8B8UVF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR D02780
gene id: 27291:SPAR_D02780
uniprot id: A0A8B8UNT3
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

27291:SPAR I01580
gene id: 27291:SPAR_I01580
uniprot id: A0A8B8UTJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.
messages: Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.
messages: Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.
messages: Nucleus

27291:SPAR J01910
gene id: 27291:SPAR_J01910
uniprot id: A0A8B8UU81
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

27291:SPAR E00940
gene id: 27291:SPAR_E00940
uniprot id: A0A8B8UPZ3
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

27291:SPAR K00500
gene id: 27291:SPAR_K00500
uniprot id: A0A8B8UUM8
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

27291:SPAR J02040
gene id: 27291:SPAR_J02040
uniprot id: A0A8B8UU43
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGM family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.
messages: Membrane

27291:SPAR B02860
gene id: 27291:SPAR_B02860
uniprot id: A0A8B8ULY2
names: Similarity
messages: Belongs to the AAA ATPase family. PCH2 subfamily.

27291:SPAR M03860
gene id: 27291:SPAR_M03860
uniprot id: A0A8B8UXX8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

27291:SPAR G03640
gene id: 27291:SPAR_G03640
uniprot id: A0A8B8US28
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

27291:SPAR P01280
gene id: 27291:SPAR_P01280
uniprot id: A0A8B8V0T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OSBP family.
messages: Membrane

27291:SPAR O03700
gene id: 27291:SPAR_O03700
uniprot id: A0A8B8V036
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR N00480
gene id: 27291:SPAR_N00480
uniprot id: A0A8B8UY33
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

27291:SPAR A00700
gene id: 27291:SPAR_A00700
uniprot id: A0A8B8UL33
names: Similarity
messages: Belongs to the protein kinase superfamily.

27291:SPAR P02970
gene id: 27291:SPAR_P02970
uniprot id: A0A8B8V1A3
names: Similarity
names: Subunit
messages: Belongs to the glutamine synthetase family.
messages: Homooctamer.

27291:SPAR H00800
gene id: 27291:SPAR_H00800
uniprot id: A0A8B8USI9
names: Function
names: Similarity
messages: Belongs to the RRF family.
messages: Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.

27291:SPAR K01620
gene id: 27291:SPAR_K01620
uniprot id: A0A8B8UUX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H3 family.
messages: Nucleus

27291:SPAR B03050
gene id: 27291:SPAR_B03050
uniprot id: A0A8B8UM09
names: Similarity
messages: Belongs to the glycosyltransferase 15 family.

27291:SPAR O03660
gene id: 27291:SPAR_O03660
uniprot id: A0A8B8V027
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Clp1 family. Clp1 subfamily.
messages: Belongs to the Clp1 family. NOL9/GRC3 subfamily.
messages: Component of the cleavage factor IA (CF IA) complex, which is a heterohexameric complex with 2:2:1:1 stoichiometry of RNA14, RNA15, PCF11 and CLP1. It contains 2 copies of a RNA14-RNA15 dimer and 1 copy of CLP1-PCF11. The complex interacts with the cleavage factor HRB1/CF IB to form the cleavage factor I (CF I) complex, and binds to RNA. Interacts directly with PCF11. Interacts with the CPF components CFT1, PTA1, PFS2, YSH1 and SSU72.
messages: Component of the cleavage factor IA (CF IA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation. Associates with HRB1/CF IB to form the cleavage factor I (CF I) complex. CF I is required for correct positioning of a larger protein complex, the cleavage and polyadenylation factor (CPF) complex, which contains the catalytic subunits executing mRNA cleavage and polyadenylation. CLP1 mediates interactions between CF IA and CPF factors. CLP1 is also involved in maintaining the CF IA interaction with the C-terminal domain of RNA Pol II largest subunit via PCF11, which links pre-mRNA 3'-end processing to transcription termination.
messages: Nucleus

27291:SPAR D01550
gene id: 27291:SPAR_D01550
uniprot id: A0A8B8UN46
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.

27291:SPAR I00960
gene id: 27291:SPAR_I00960
uniprot id: A0A8B8UTF5
names: Similarity
messages: Belongs to the SEC6 family.

27291:SPAR N03640
gene id: 27291:SPAR_N03640
uniprot id: A0A8B8UYZ9
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR K00090
gene id: 27291:SPAR_K00090
uniprot id: A0A8B8UUI2
names: Similarity
messages: Belongs to the oxoprolinase family.

27291:SPAR E00880
gene id: 27291:SPAR_E00880
uniprot id: A0A8B8UQ90
names: Subcellular Location Annotation
messages: Nucleus
messages: kinetochore

27291:SPAR P00600
gene id: 27291:SPAR_P00600
uniprot id: A0A8B8V0M1
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR O04890
gene id: 27291:SPAR_O04890
uniprot id: A0A8B8V0J4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.
messages: Membrane

27291:SPAR L03220
gene id: 27291:SPAR_L03220
uniprot id: A0A8B8UWG5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Mitochondrion

27291:SPAR M03460
gene id: 27291:SPAR_M03460
uniprot id: A0A8B8UXT5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

27291:SPAR H02240
gene id: 27291:SPAR_H02240
uniprot id: A0A8B8UT25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

27291:SPAR O02820
gene id: 27291:SPAR_O02820
uniprot id: A0A8B8UZZ1
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR G00530
gene id: 27291:SPAR_G00530
uniprot id: A0A8B8UQW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

27291:SPAR N01300
gene id: 27291:SPAR_N01300
uniprot id: A0A8B8UYG9
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR F01180
gene id: 27291:SPAR_F01180
uniprot id: A0A8B8UQR7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

27291:SPAR E02190
gene id: 27291:SPAR_E02190
uniprot id: A0A8B8UQB6
names: Similarity
messages: Belongs to the peptidase C19 family.

27291:SPAR P01710
gene id: 27291:SPAR_P01710
uniprot id: A0A8B8V116
names: Similarity
messages: Belongs to the MGR2 family.

27291:SPAR D03460
gene id: 27291:SPAR_D03460
uniprot id: A0A8B8UNN5
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR G02620
gene id: 27291:SPAR_G02620
uniprot id: A0A8B8URL5
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

27291:SPAR O02210
gene id: 27291:SPAR_O02210
uniprot id: A0A8B8UZP0
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR G00400
gene id: 27291:SPAR_G00400
uniprot id: A0A8B8UQV8
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

27291:SPAR D03030
gene id: 27291:SPAR_D03030
uniprot id: A0A8B8UNW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR C00620
gene id: 27291:SPAR_C00620
uniprot id: A0A8B8UMF3
names: Similarity
messages: Belongs to the WrbA family.

27291:SPAR H02380
gene id: 27291:SPAR_H02380
uniprot id: A0A8B8USU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RIX1/PELP1 family.
messages: Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-60S ribosomal subunits. Regulates pre-60S association of the critical remodeling factor MDN1.
messages: Nucleus

27291:SPAR O00770
gene id: 27291:SPAR_O00770
uniprot id: A0A8B8UZE0
names: Similarity
messages: Belongs to the MDM20/NAA25 family.

27291:SPAR H00240
gene id: 27291:SPAR_H00240
uniprot id: A0A8B8USA6
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

27291:SPAR L00830
gene id: 27291:SPAR_L00830
uniprot id: A0A8B8UVK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

27291:SPAR L02100
gene id: 27291:SPAR_L02100
uniprot id: A0A8B8UVY7
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

27291:SPAR G03330
gene id: 27291:SPAR_G03330
uniprot id: A0A8B8URP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex DAM1 family.
messages: Nucleus
messages: kinetochore
messages: spindle

27291:SPAR O01580
gene id: 27291:SPAR_O01580
uniprot id: A0A8B8UZG8
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR J03240
gene id: 27291:SPAR_J03240
uniprot id: A0A8B8UUG2
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

27291:SPAR B01940
gene id: 27291:SPAR_B01940
uniprot id: A0A8B8ULP6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

27291:SPAR J02550
gene id: 27291:SPAR_J02550
uniprot id: A0A8B8UUA1
names: Similarity
messages: Belongs to the MOG1 family.

27291:SPAR M02470
gene id: 27291:SPAR_M02470
uniprot id: A0A8B8UXD5
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR D06340
gene id: 27291:SPAR_D06340
uniprot id: A0A8B8UPS7
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

27291:SPAR G01940
gene id: 27291:SPAR_G01940
uniprot id: A0A8B8URK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFS-II family.
messages: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.
messages: Nucleus

27291:SPAR B03870
gene id: 27291:SPAR_B03870
uniprot id: A0A8B8UM57
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR G01650
gene id: 27291:SPAR_G01650
uniprot id: A0A8B8UR82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KXD1 family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.
messages: Endosome

27291:SPAR D00900
gene id: 27291:SPAR_D00900
uniprot id: A0A8B8UMX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP14 family.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.
messages: nucleolus

27291:SPAR B01850
gene id: 27291:SPAR_B01850
uniprot id: A0A8B8ULN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TEC1 family.
messages: Nucleus

27291:SPAR O01270
gene id: 27291:SPAR_O01270
uniprot id: A0A8B8UZI9
names: Similarity
messages: Belongs to the RNR ribonuclease family.

27291:SPAR L04320
gene id: 27291:SPAR_L04320
uniprot id: A0A8B8UWS6
names: Subcellular Location Annotation
messages: Cytoplasm

27291:SPAR L03670
gene id: 27291:SPAR_L03670
uniprot id: A0A8B8UWL0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Mitochondrion

27291:SPAR K01290
gene id: 27291:SPAR_K01290
uniprot id: A0A8B8UUU9
names: Similarity
messages: Belongs to the SURF6 family.

27291:SPAR O01510
gene id: 27291:SPAR_O01510
uniprot id: A0A8B8UZG7
names: Subcellular Location Annotation
messages: nucleolus

27291:SPAR K01100
gene id: 27291:SPAR_K01100
uniprot id: A0A8B8UUT4
names: Similarity
messages: Belongs to the peptidase M18 family.

27291:SPAR B00540
gene id: 27291:SPAR_B00540
uniprot id: A0A8B8ULA2
names: Similarity
messages: Belongs to the MYST (SAS/MOZ) family.

27291:SPAR D05690
gene id: 27291:SPAR_D05690
uniprot id: A0A8B8UPA4
names: Similarity
messages: Belongs to the complex I LYR family. SDHAF1 subfamily.

27291:SPAR D00030
gene id: 27291:SPAR_D00030
uniprot id: A0A8B8UN02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR L04270
gene id: 27291:SPAR_L04270
uniprot id: A0A8B8UWR9
names: Similarity
messages: Belongs to the DOCK family.

27291:SPAR J01840
gene id: 27291:SPAR_J01840
uniprot id: A0A8B8UU28
names: Similarity
messages: Belongs to the cyclin family.

27291:SPAR K00710
gene id: 27291:SPAR_K00710
uniprot id: A0A8B8UUU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Vacuole membrane

27291:SPAR G02810
gene id: 27291:SPAR_G02810
uniprot id: A0A8B8URN5
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR F00420
gene id: 27291:SPAR_F00420
uniprot id: A0A8B8UQU2
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR L02440
gene id: 27291:SPAR_L02440
uniprot id: A0A8B8UW64
names: Function
names: Similarity
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome.

27291:SPAR D05820
gene id: 27291:SPAR_D05820
uniprot id: A0A8B8UPA8
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR D06320
gene id: 27291:SPAR_D06320
uniprot id: A0A8B8UPG7
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR D06590
gene id: 27291:SPAR_D06590
uniprot id: A0A8B8UPV1
names: Cofactor
names: Similarity
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.

27291:SPAR E00490
gene id: 27291:SPAR_E00490
uniprot id: A0A8B8UPU6
names: Similarity
messages: Belongs to the OMP decarboxylase family.

27291:SPAR L00740
gene id: 27291:SPAR_L00740
uniprot id: A0A8B8UVK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus

27291:SPAR H02220
gene id: 27291:SPAR_H02220
uniprot id: A0A8B8USY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVP26 family.
messages: Membrane

27291:SPAR O02700
gene id: 27291:SPAR_O02700
uniprot id: A0A8B8UZS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

27291:SPAR E01810
gene id: 27291:SPAR_E01810
uniprot id: A0A8B8UQ86
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS8 family.

27291:SPAR J02740
gene id: 27291:SPAR_J02740
uniprot id: A0A8B8UUB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR L02670
gene id: 27291:SPAR_L02670
uniprot id: A0A8B8UWA8
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

27291:SPAR O04030
gene id: 27291:SPAR_O04030
uniprot id: A0A8B8V065
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

27291:SPAR O02960
gene id: 27291:SPAR_O02960
uniprot id: A0A8B8UZW4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

27291:SPAR N02140
gene id: 27291:SPAR_N02140
uniprot id: A0A8B8UYK0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

27291:SPAR E00580
gene id: 27291:SPAR_E00580
uniprot id: A0A8B8UQ58
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

27291:SPAR M03930
gene id: 27291:SPAR_M03930
uniprot id: A0A8B8UXT6
names: Similarity
messages: Belongs to the phosphohexose mutase family.

27291:SPAR P02650
gene id: 27291:SPAR_P02650
uniprot id: A0A8B8V181
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

27291:SPAR I00840
gene id: 27291:SPAR_I00840
uniprot id: A0A8B8UTA1
names: Similarity
messages: Belongs to the PPC synthetase family.

27291:SPAR E01600
gene id: 27291:SPAR_E01600
uniprot id: A0A8B8UQ69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GET2 family.
messages: Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in DNA replication and DNA damage response and also in cell wall function.

27291:SPAR M00180
gene id: 27291:SPAR_M00180
uniprot id: A0A8B8UWR0
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR P01920
gene id: 27291:SPAR_P01920
uniprot id: A0A8B8V0Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGC family.
messages: Membrane

27291:SPAR N01740
gene id: 27291:SPAR_N01740
uniprot id: A0A8B8UYG7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.
messages: Cytoplasm
messages: Nucleus

27291:SPAR G01060
gene id: 27291:SPAR_G01060
uniprot id: A0A8B8UR58
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

27291:SPAR M01450
gene id: 27291:SPAR_M01450
uniprot id: A0A8B8UX40
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR M00360
gene id: 27291:SPAR_M00360
uniprot id: A0A8B8UWX4
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR C00470
gene id: 27291:SPAR_C00470
uniprot id: A0A8B8UMD7
names: Similarity
messages: Belongs to the DCC1 family.

27291:SPAR M01390
gene id: 27291:SPAR_M01390
uniprot id: A0A8B8UX89
names: Similarity
messages: Belongs to the cytochrome P450 family.

27291:SPAR F01160
gene id: 27291:SPAR_F01160
uniprot id: A0A8B8UQQ6
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

27291:SPAR B02340
gene id: 27291:SPAR_B02340
uniprot id: A0A8B8ULT9
names: Function
names: Similarity
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.

27291:SPAR H02560
gene id: 27291:SPAR_H02560
uniprot id: A0A8B8UL51
names: Similarity
messages: Belongs to the histidine acid phosphatase family.

27291:SPAR O00680
gene id: 27291:SPAR_O00680
uniprot id: A0A8B8UZ80
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

27291:SPAR O03900
gene id: 27291:SPAR_O03900
uniprot id: A0A8B8V053
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1 and EAP1 for binding to eIF4E and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA.
messages: Belongs to the CAF20 family.
messages: Cytoplasm

27291:SPAR O03400
gene id: 27291:SPAR_O03400
uniprot id: A0A8B8V009
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the activator 1 large subunit family.
messages: Nucleus

27291:SPAR L00850
gene id: 27291:SPAR_L00850
uniprot id: A0A8B8UVS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PurH family.
messages: cytosol

27291:SPAR A00660
gene id: 27291:SPAR_A00660
uniprot id: A0A8B8UL16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.
messages: Belongs to the replication factor A protein 1 family.
messages: Component of the heterotrimeric canonical replication protein A complex (RPA).
messages: Nucleus

27291:SPAR J02450
gene id: 27291:SPAR_J02450
uniprot id: A0A8B8UU88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

27291:SPAR D05100
gene id: 27291:SPAR_D05100
uniprot id: A0A8B8UP56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIT family. Yeast FIT2A/YFT2 subfamily.
messages: Endoplasmic reticulum membrane
messages: Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization). Involved in phospholipid biosynthesis.
messages: Membrane

27291:SPAR K00040
gene id: 27291:SPAR_K00040
uniprot id: A0A8B8UUH7
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR L03610
gene id: 27291:SPAR_L03610
uniprot id: A0A8B8UWD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

27291:SPAR H01370
gene id: 27291:SPAR_H01370
uniprot id: A0A8B8USK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR A00460
gene id: 27291:SPAR_A00460
uniprot id: A0A8B8UKZ0
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR D04340
gene id: 27291:SPAR_D04340
uniprot id: A0A8B8UNX3
names: Function
names: Similarity
messages: Belongs to the flavokinase family.
messages: Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.

27291:SPAR P00040
gene id: 27291:SPAR_P00040
uniprot id: A0A8B8V0K8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.
messages: Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

27291:SPAR J00120
gene id: 27291:SPAR_J00120
uniprot id: A0A8B8UTJ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.
messages: Membrane
messages: Peroxisome membrane

27291:SPAR D04240
gene id: 27291:SPAR_D04240
uniprot id: A0A8B8UNW4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

27291:SPAR J01820
gene id: 27291:SPAR_J01820
uniprot id: A0A8B8UU21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NOP9 family.
messages: Component of the 90S pre-ribosome. Component of the pre-40S ribosome.
messages: RNA-binding nucleolar protein required for pre-rRNA processing. Component of the 90S pre-ribosome involved in production of 18S rRNA and assembly of small ribosomal subunit. Component of the pre-40S ribosome required for release from the nucleolus.

27291:SPAR L04250
gene id: 27291:SPAR_L04250
uniprot id: A0A8B8UWK7
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.

27291:SPAR D02070
gene id: 27291:SPAR_D02070
uniprot id: A0A8B8UN80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OSBP family.
messages: Membrane

27291:SPAR G03240
gene id: 27291:SPAR_G03240
uniprot id: A0A8B8URY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pescadillo family.
messages: Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.
messages: Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

27291:SPAR D02300
gene id: 27291:SPAR_D02300
uniprot id: A0A8B8UNC3
names: Similarity
messages: Belongs to the TrpF family.

27291:SPAR A00090
gene id: 27291:SPAR_A00090
uniprot id: A0A8B8UKT5
names: Similarity
messages: Belongs to the calreticulin family.

27291:SPAR G03710
gene id: 27291:SPAR_G03710
uniprot id: A0A8B8URX6
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR M04380
gene id: 27291:SPAR_M04380
uniprot id: A0A8B8UXY3
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR D04780
gene id: 27291:SPAR_D04780
uniprot id: A0A8B8UPC9
names: Similarity
messages: Belongs to the glutaredoxin family.

27291:SPAR N02980
gene id: 27291:SPAR_N02980
uniprot id: A0A8B8UYY4
names: Similarity
messages: Belongs to the WD repeat LST8 family.

27291:SPAR M01350
gene id: 27291:SPAR_M01350
uniprot id: A0A8B8UX29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR G02050
gene id: 27291:SPAR_G02050
uniprot id: A0A8B8URB8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

27291:SPAR E01630
gene id: 27291:SPAR_E01630
uniprot id: A0A8B8UQF3
names: Similarity
messages: Belongs to the serine/threonine dehydratase family.

27291:SPAR B02970
gene id: 27291:SPAR_B02970
uniprot id: A0A8B8ULW4
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

27291:SPAR G00030
gene id: 27291:SPAR_G00030
uniprot id: A0A8B8UQQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VEL1 family.
messages: cytosol

27291:SPAR D05230
gene id: 27291:SPAR_D05230
uniprot id: A0A8B8UPH5
names: Similarity
messages: Belongs to the peptidase C13 family.

27291:SPAR G03650
gene id: 27291:SPAR_G03650
uniprot id: A0A8B8URS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPC1 family.
messages: Membrane

27291:SPAR N03500
gene id: 27291:SPAR_N03500
uniprot id: A0A8B8UYZ0
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

27291:SPAR D00570
gene id: 27291:SPAR_D00570
uniprot id: A0A8B8UMS9
names: Similarity
messages: Belongs to the PPP phosphatase family.

27291:SPAR B03020
gene id: 27291:SPAR_B03020
uniprot id: A0A8B8ULX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Nucleus

27291:SPAR K03080
gene id: 27291:SPAR_K03080
uniprot id: A0A8B8UVI0
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR F01060
gene id: 27291:SPAR_F01060
uniprot id: A0A8B8UQP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR J01240
gene id: 27291:SPAR_J01240
uniprot id: A0A8B8UTX3
names: Similarity
messages: Belongs to the actin family.

27291:SPAR G04560
gene id: 27291:SPAR_G04560
uniprot id: A0A8B8US60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2H phosphoesterase superfamily. CPD1 family.
messages: Golgi apparatus
messages: Involved in the metabolism of ADP-ribose 1',2'-cyclic phosphate which is produced as a consequence of tRNA splicing.

27291:A560 mgp06
gene id: 27291:A560_mgp06
uniprot id: I1Z687
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR M01060
gene id: 27291:SPAR_M01060
uniprot id: A0A8B8UX47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
messages: Mitochondrion
messages: Nucleus

27291:SPAR P03950
gene id: 27291:SPAR_P03950
uniprot id: A0A8B8V1L1
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR K00460
gene id: 27291:SPAR_K00460
uniprot id: A0A8B8UUS2
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR D04640
gene id: 27291:SPAR_D04640
uniprot id: A0A8B8UP01
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

27291:SPAR D05720
gene id: 27291:SPAR_D05720
uniprot id: A0A8B8UP99
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.

27291:SPAR M01630
gene id: 27291:SPAR_M01630
uniprot id: A0A8B8UX54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcriptional coactivator PC4 family.
messages: Nucleus

27291:SPAR F00860
gene id: 27291:SPAR_F00860
uniprot id: A0A8B8UQM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. ECO subfamily.
messages: Nucleus

27291:SPAR F00060
gene id: 27291:SPAR_F00060
uniprot id: A0A8B8UQF0
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR N03170
gene id: 27291:SPAR_N03170
uniprot id: A0A8B8UYV1
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

27291:SPAR A00290
gene id: 27291:SPAR_A00290
uniprot id: A0A8B8UKW5
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.

27291:SPAR L02010
gene id: 27291:SPAR_L02010
uniprot id: A0A8B8UVY0
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

27291:SPAR D04830
gene id: 27291:SPAR_D04830
uniprot id: A0A8B8UPD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Endoplasmic reticulum membrane

27291:SPAR J03150
gene id: 27291:SPAR_J03150
uniprot id: A0A8B8UUF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IML1 family.
messages: Membrane
messages: Vacuole membrane

27291:SPAR E00570
gene id: 27291:SPAR_E00570
uniprot id: A0A8B8UPU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-catenin family.
messages: Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.
messages: Membrane
messages: Vacuole membrane

27291:SPAR K02320
gene id: 27291:SPAR_K02320
uniprot id: A0A8B8UV45
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

27291:SPAR P02860
gene id: 27291:SPAR_P02860
uniprot id: A0A8B8V1C7
names: Similarity
messages: Belongs to the cyclin family. Cyclin C subfamily.

27291:SPAR P00540
gene id: 27291:SPAR_P00540
uniprot id: A0A8B8V0Q7
names: Similarity
messages: Belongs to the SELO family.

27291:SPAR H02270
gene id: 27291:SPAR_H02270
uniprot id: A0A8B8USY5
names: Similarity
messages: Belongs to the WD repeat RAPTOR family.

27291:SPAR J01420
gene id: 27291:SPAR_J01420
uniprot id: A0A8B8UTY4
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

27291:SPAR D07080
gene id: 27291:SPAR_D07080
uniprot id: A0A8B8UPN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR D05250
gene id: 27291:SPAR_D05250
uniprot id: A0A8B8UP73
names: Similarity
messages: Belongs to the TCF25 family.

27291:SPAR L04230
gene id: 27291:SPAR_L04230
uniprot id: A0A8B8UWK6
names: Similarity
messages: Belongs to the CDC73 family.

27291:SPAR G04540
gene id: 27291:SPAR_G04540
uniprot id: A0A8B8USB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDA1 family.
messages: Required for 60S pre-ribosomal subunits export to the cytoplasm.
messages: nucleolus

27291:SPAR P04230
gene id: 27291:SPAR_P04230
uniprot id: A0A8B8V1M6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane

27291:SPAR M00280
gene id: 27291:SPAR_M00280
uniprot id: A0A8B8UWS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

27291:SPAR D04310
gene id: 27291:SPAR_D04310
uniprot id: A0A8B8UNX2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR D00120
gene id: 27291:SPAR_D00120
uniprot id: A0A8B8UMN5
names: Similarity
messages: Belongs to the AIM6 family.

27291:SPAR O03630
gene id: 27291:SPAR_O03630
uniprot id: A0A8B8V025
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

27291:SPAR D04610
gene id: 27291:SPAR_D04610
uniprot id: A0A8B8UP03
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.
messages: Membrane
messages: Peroxisome membrane

27291:SPAR M01830
gene id: 27291:SPAR_M01830
uniprot id: A0A8B8UX72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AEP1 family.
messages: Mitochondrion
messages: Required for translation of the mitochondrial OLI1 transcript encoding subunit 9 of mitochondrial ATP synthase.

27291:SPAR O00270
gene id: 27291:SPAR_O00270
uniprot id: A0A8B8UZ88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

27291:SPAR G02610
gene id: 27291:SPAR_G02610
uniprot id: A0A8B8URL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM21 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR K02770
gene id: 27291:SPAR_K02770
uniprot id: A0A8B8UV93
names: Similarity
messages: Belongs to the UPF0538 family.

27291:SPAR M03410
gene id: 27291:SPAR_M03410
uniprot id: A0A8B8UXT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL53 family.
messages: Mitochondrion

27291:SPAR M00720
gene id: 27291:SPAR_M00720
uniprot id: A0A8B8UWW2
names: Function
names: Similarity
messages: Belongs to the type-1 OGG1 family.
messages: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

27291:SPAR D03840
gene id: 27291:SPAR_D03840
uniprot id: A0A8B8UNS6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CybS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR P04260
gene id: 27291:SPAR_P04260
uniprot id: A0A8B8V1T9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycogen debranching enzyme family.
messages: Cytoplasm
messages: Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.

27291:SPAR N03190
gene id: 27291:SPAR_N03190
uniprot id: A0A8B8UYV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR J03010
gene id: 27291:SPAR_J03010
uniprot id: A0A8B8UUJ4
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR K01230
gene id: 27291:SPAR_K01230
uniprot id: A0A8B8UUZ7
names: Similarity
messages: Belongs to the CENP-C/MIF2 family.

27291:SPAR J00330
gene id: 27291:SPAR_J00330
uniprot id: A0A8B8UTR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GON7 family.
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.
messages: Nucleus

27291:SPAR O03650
gene id: 27291:SPAR_O03650
uniprot id: A0A8B8V033
names: Similarity
messages: Belongs to the APC5 family.

27291:SPAR K02650
gene id: 27291:SPAR_K02650
uniprot id: A0A8B8UV94
names: Similarity
messages: Belongs to the glycosyltransferase 15 family.

27291:SPAR G01360
gene id: 27291:SPAR_G01360
uniprot id: A0A8B8UR89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSA1 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

27291:SPAR E02310
gene id: 27291:SPAR_E02310
uniprot id: A0A8B8UQD6
names: Similarity
messages: Belongs to the MYG1 family.

27291:SPAR G04320
gene id: 27291:SPAR_G04320
uniprot id: A0A8B8US35
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

27291:SPAR O00690
gene id: 27291:SPAR_O00690
uniprot id: A0A8B8UZC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

27291:SPAR N03280
gene id: 27291:SPAR_N03280
uniprot id: A0A8B8UZ13
names: Similarity
messages: Belongs to the pyridoxine kinase family.

27291:SPAR G01500
gene id: 27291:SPAR_G01500
uniprot id: A0A8B8UR69
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

27291:SPAR D04890
gene id: 27291:SPAR_D04890
uniprot id: A0A8B8UP26
names: Similarity
messages: Belongs to the ATPase delta chain family.

27291:SPAR D00930
gene id: 27291:SPAR_D00930
uniprot id: A0A8B8UN93
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

27291:SPAR B01730
gene id: 27291:SPAR_B01730
uniprot id: A0A8B8ULZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ALG14 family.
messages: Endoplasmic reticulum membrane
messages: Heterodimer with ALG13 to form a functional enzyme.
messages: Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.
messages: Membrane
messages: Nucleus membrane

27291:SPAR L02470
gene id: 27291:SPAR_L02470
uniprot id: A0A8B8UW88
names: Similarity
messages: Belongs to the CDC123 family.

27291:SPAR G02550
gene id: 27291:SPAR_G02550
uniprot id: A0A8B8URG6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

27291:SPAR F00210
gene id: 27291:SPAR_F00210
uniprot id: A0A8B8UQG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YSP2 family.
messages: Membrane

27291:SPAR J01480
gene id: 27291:SPAR_J01480
uniprot id: A0A8B8UU23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIM54 family.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR C00960
gene id: 27291:SPAR_C00960
uniprot id: A0A8B8UMJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF2 family.
messages: Nucleus

27291:SPAR J00280
gene id: 27291:SPAR_J00280
uniprot id: A0A8B8UTQ6
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.

27291:SPAR E00430
gene id: 27291:SPAR_E00430
uniprot id: A0A8B8UQ42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.
messages: Vacuole membrane

27291:SPAR G04440
gene id: 27291:SPAR_G04440
uniprot id: A0A8B8USA3
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

27291:SPAR J02540
gene id: 27291:SPAR_J02540
uniprot id: A0A8B8UU92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
messages: Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

27291:SPAR H00600
gene id: 27291:SPAR_H00600
uniprot id: A0A8B8USG8
names: Similarity
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

27291:SPAR B02700
gene id: 27291:SPAR_B02700
uniprot id: A0A8B8ULX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPL4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus membrane
messages: perinuclear region

27291:SPAR D03490
gene id: 27291:SPAR_D03490
uniprot id: A0A8B8UNP2
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

27291:SPAR N00810
gene id: 27291:SPAR_N00810
uniprot id: A0A8B8UY72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
messages: nucleolus

27291:SPAR O03170
gene id: 27291:SPAR_O03170
uniprot id: A0A8B8V026
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

27291:SPAR N00440
gene id: 27291:SPAR_N00440
uniprot id: A0A8B8UY36
names: Similarity
messages: Belongs to the cyclin family.

27291:SPAR C00250
gene id: 27291:SPAR_C00250
uniprot id: A0A8B8UMC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen
messages: Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.

27291:SPAR A00510
gene id: 27291:SPAR_A00510
uniprot id: A0A8B8UKZ6
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR O00810
gene id: 27291:SPAR_O00810
uniprot id: A0A8B8UZ98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDHAF2 family.
messages: Interacts with the flavoprotein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.

27291:SPAR N01480
gene id: 27291:SPAR_N01480
uniprot id: A0A8B8UYD4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: Mitochondrion inner membrane

27291:SPAR P01860
gene id: 27291:SPAR_P01860
uniprot id: A0A8B8V131
names: Similarity
messages: Belongs to the SEN54 family.

27291:SPAR D00780
gene id: 27291:SPAR_D00780
uniprot id: A0A8B8UN79
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.

27291:SPAR I01830
gene id: 27291:SPAR_I01830
uniprot id: A0A8B8UTL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

27291:SPAR O00230
gene id: 27291:SPAR_O00230
uniprot id: A0A8B8UZ36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 7 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

27291:SPAR L02250
gene id: 27291:SPAR_L02250
uniprot id: A0A8B8UW04
names: Similarity
messages: Belongs to the peroxin-13 family.

27291:SPAR H00400
gene id: 27291:SPAR_H00400
uniprot id: A0A8B8USE8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

27291:SPAR O00070
gene id: 27291:SPAR_O00070
uniprot id: A0A8B8UZ71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferric reductase (FRE) family.
messages: Cell membrane
messages: Membrane

27291:SPAR D06120
gene id: 27291:SPAR_D06120
uniprot id: A0A8B8UPF1
names: Similarity
messages: Belongs to the proteasome subunit S11 family.

27291:SPAR K02910
gene id: 27291:SPAR_K02910
uniprot id: A0A8B8UVG6
names: Function
names: Similarity
messages: Belongs to the TVP38/TMEM64 family.
messages: Golgi membrane protein involved in vesicular trafficking and spindle migration.

27291:SPAR E00510
gene id: 27291:SPAR_E00510
uniprot id: A0A8B8UPU9
names: Similarity
messages: Belongs to the TPP enzyme family.

27291:SPAR K01610
gene id: 27291:SPAR_K01610
uniprot id: A0A8B8UV37
names: Similarity
messages: Belongs to the EIS1 family.

27291:SPAR D04090
gene id: 27291:SPAR_D04090
uniprot id: A0A8B8UNU8
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in nonsense-mediated mRNA decay.

27291:SPAR A00030
gene id: 27291:SPAR_A00030
uniprot id: A0A8B8UL98
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR K02850
gene id: 27291:SPAR_K02850
uniprot id: A0A8B8UVB4
names: Similarity
messages: Belongs to the nucleoporin Nup133 family.

27291:SPAR M02120
gene id: 27291:SPAR_M02120
uniprot id: A0A8B8UX99
names: Similarity
messages: Belongs to the glutaminase PdxT/SNO family.

27291:SPAR D04420
gene id: 27291:SPAR_D04420
uniprot id: A0A8B8UNW3
names: Similarity
messages: Belongs to the glycosyltransferase 34 family.

27291:SPAR H00200
gene id: 27291:SPAR_H00200
uniprot id: A0A8B8USC9
names: Similarity
messages: Belongs to the TOP6A family.

27291:SPAR K01710
gene id: 27291:SPAR_K01710
uniprot id: A0A8B8UV47
names: Similarity
messages: Belongs to the NifU family.

27291:SPAR I00610
gene id: 27291:SPAR_I00610
uniprot id: A0A8B8UTB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: Cytoplasm

27291:SPAR D06200
gene id: 27291:SPAR_D06200
uniprot id: A0A8B8UPF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPI19 family.
messages: Component of the phosphatidylinositol N-acetylglucosaminyltransferase (GPI-GlcNAc transferase) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

27291:SPAR P00640
gene id: 27291:SPAR_P00640
uniprot id: A0A8B8V0R8
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

27291:SPAR B03890
gene id: 27291:SPAR_B03890
uniprot id: A0A8B8UM98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane

27291:SPAR B02770
gene id: 27291:SPAR_B02770
uniprot id: A0A8B8ULU7
names: Subcellular Location Annotation
messages: Mitochondrion outer membrane

27291:SPAR L00790
gene id: 27291:SPAR_L00790
uniprot id: A0A8B8UVL0
names: Similarity
messages: Belongs to the SDO1/SBDS family.

27291:SPAR F00840
gene id: 27291:SPAR_F00840
uniprot id: A0A8B8UQR8
names: Similarity
messages: Belongs to the SH3YL1 family.

27291:SPAR O00540
gene id: 27291:SPAR_O00540
uniprot id: A0A8B8UZB1
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.

27291:SPAR E01130
gene id: 27291:SPAR_E01130
uniprot id: A0A8B8UQB4
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.

27291:SPAR K02340
gene id: 27291:SPAR_K02340
uniprot id: A0A8B8UV53
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

27291:SPAR J00970
gene id: 27291:SPAR_J00970
uniprot id: A0A8B8UTS9
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR K00820
gene id: 27291:SPAR_K00820
uniprot id: A0A8B8UUQ3
names: Function
names: Similarity
messages: Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
messages: Belongs to the adaptor complexes large subunit family.

27291:SPAR C01060
gene id: 27291:SPAR_C01060
uniprot id: A0A8B8UMK0
names: Function
names: Similarity
messages: Belongs to the CTR86 family.
messages: Essential protein which may be involved in threonine biosynthesis.

27291:SPAR H02400
gene id: 27291:SPAR_H02400
uniprot id: A0A8B8USX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM18/AIM46 family.
messages: Mitochondrion

27291:SPAR O04620
gene id: 27291:SPAR_O04620
uniprot id: A0A8B8V0H7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VTS1 family.
messages: Monomer. Binds to RNA.
messages: P-body
messages: cytosol

27291:SPAR L04420
gene id: 27291:SPAR_L04420
uniprot id: A0A8B8UWT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

27291:SPAR D01470
gene id: 27291:SPAR_D01470
uniprot id: A0A8B8UN20
names: Subcellular Location Annotation
messages: nuclear pore complex

27291:SPAR J01090
gene id: 27291:SPAR_J01090
uniprot id: A0A8B8UTV5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

27291:SPAR M03510
gene id: 27291:SPAR_M03510
uniprot id: A0A8B8UXU0
names: Function
names: Similarity
messages: Belongs to the RNase H family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

27291:SPAR O00120
gene id: 27291:SPAR_O00120
uniprot id: A0A8B8UZ74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS3/PSF3 family.
messages: Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

27291:SPAR F00310
gene id: 27291:SPAR_F00310
uniprot id: A0A8B8UQH5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

27291:SPAR B02590
gene id: 27291:SPAR_B02590
uniprot id: A0A8B8ULW6
names: Similarity
messages: Belongs to the protein kinase superfamily.

27291:SPAR B03000
gene id: 27291:SPAR_B03000
uniprot id: A0A8B8UM05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
messages: Membrane

27291:SPAR B03290
gene id: 27291:SPAR_B03290
uniprot id: A0A8B8UM35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex DAD3 family.
messages: Nucleus
messages: kinetochore
messages: spindle

27291:SPAR L03510
gene id: 27291:SPAR_L03510
uniprot id: A0A8B8UWD1
names: Similarity
messages: Belongs to the CWC22 family.

27291:SPAR N01950
gene id: 27291:SPAR_N01950
uniprot id: A0A8B8UYI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTU2/NCS2 family.
messages: Cytoplasm
messages: Interacts with NCS6 and URM1. May act by forming a heterodimer with NCS6.
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.

27291:SPAR G03220
gene id: 27291:SPAR_G03220
uniprot id: A0A8B8URS6
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR L00530
gene id: 27291:SPAR_L00530
uniprot id: A0A8B8UVH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

27291:SPAR I01670
gene id: 27291:SPAR_I01670
uniprot id: A0A8B8UTF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cut8/STS1 family.
messages: Binds the proteasome. Interacts with karyopherin SRP1 and Proteasome subunit RPN11.
messages: Cytoplasm
messages: Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.
messages: Nucleus

27291:SPAR B01080
gene id: 27291:SPAR_B01080
uniprot id: A0A8B8ULT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Membrane

27291:SPAR L03980
gene id: 27291:SPAR_L03980
uniprot id: A0A8B8UWI1
names: Similarity
messages: Belongs to the peptidase M16 family.

27291:SPAR F00450
gene id: 27291:SPAR_F00450
uniprot id: A0A8B8UQM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

27291:SPAR J01970
gene id: 27291:SPAR_J01970
uniprot id: A0A8B8UU35
names: Similarity
messages: Belongs to the eIF-2-alpha family.

27291:SPAR K00410
gene id: 27291:SPAR_K00410
uniprot id: A0A8B8UUR7
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

27291:SPAR O00200
gene id: 27291:SPAR_O00200
uniprot id: A0A8B8UZ29
names: Similarity
messages: Belongs to the WD repeat RTC1 family.

27291:SPAR G04050
gene id: 27291:SPAR_G04050
uniprot id: A0A8B8URW8
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

27291:SPAR O01720
gene id: 27291:SPAR_O01720
uniprot id: A0A8B8UZN2
names: Subcellular Location Annotation
messages: Cytoplasm

27291:SPAR K01570
gene id: 27291:SPAR_K01570
uniprot id: A0A8B8UUX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEF1 family.
messages: Cytoplasm
messages: Nucleus
messages: telomere

27291:SPAR M00320
gene id: 27291:SPAR_M00320
uniprot id: A0A8B8UWS4
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR E01140
gene id: 27291:SPAR_E01140
uniprot id: A0A8B8UQ11
names: Cofactor
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.
messages: Binds 1 NAD(+) per subunit.

27291:SPAR B00320
gene id: 27291:SPAR_B00320
uniprot id: A0A8B8UL23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG8 family.
messages: Membrane
messages: autophagosome membrane

27291:SPAR G02660
gene id: 27291:SPAR_G02660
uniprot id: A0A8B8URM2
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR D04430
gene id: 27291:SPAR_D04430
uniprot id: A0A8B8UP95
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

27291:SPAR J03330
gene id: 27291:SPAR_J03330
uniprot id: A0A8B8UUL8
names: Similarity
messages: Belongs to the PdxS/SNZ family.

27291:SPAR B02450
gene id: 27291:SPAR_B02450
uniprot id: A0A8B8ULU9
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

27291:SPAR B00720
gene id: 27291:SPAR_B00720
uniprot id: A0A8B8UL80
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.

27291:SPAR D05650
gene id: 27291:SPAR_D05650
uniprot id: A0A8B8UPB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferredoxin--NADP reductase type 1 family.
messages: Mitochondrion

27291:SPAR N03320
gene id: 27291:SPAR_N03320
uniprot id: A0A8B8UYW6
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

27291:SPAR O04440
gene id: 27291:SPAR_O04440
uniprot id: A0A8B8V0F0
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

27291:SPAR J00370
gene id: 27291:SPAR_J00370
uniprot id: A0A8B8UTM1
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

27291:SPAR O04710
gene id: 27291:SPAR_O04710
uniprot id: A0A8B8V0D2
names: Function
names: Similarity
messages: Belongs to the Rab GDI family.
messages: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

27291:SPAR I01500
gene id: 27291:SPAR_I01500
uniprot id: A0A8B8UTC8
names: Similarity
messages: Belongs to the proteasome subunit p27 family.

27291:SPAR O02770
gene id: 27291:SPAR_O02770
uniprot id: A0A8B8UZY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPP2 family.
messages: Involved in spliceosome maturation and the first step of pre-mRNA splicing.
messages: Nucleus

27291:SPAR L01960
gene id: 27291:SPAR_L01960
uniprot id: A0A8B8UVX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS18 family.
messages: Membrane

27291:SPAR G00960
gene id: 27291:SPAR_G00960
uniprot id: A0A8B8UR48
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

27291:SPAR D05310
gene id: 27291:SPAR_D05310
uniprot id: A0A8B8UP71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP23/FCF1 family. FCF1 subfamily.
messages: nucleolus

27291:SPAR D03090
gene id: 27291:SPAR_D03090
uniprot id: A0A8B8UNK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

27291:SPAR G01790
gene id: 27291:SPAR_G01790
uniprot id: A0A8B8URJ2
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
messages: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

27291:SPAR J01130
gene id: 27291:SPAR_J01130
uniprot id: A0A8B8UTY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

27291:SPAR M04070
gene id: 27291:SPAR_M04070
uniprot id: A0A8B8UXU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOT1 family.
messages: Golgi apparatus membrane
messages: Membrane

27291:SPAR K01680
gene id: 27291:SPAR_K01680
uniprot id: A0A8B8UV43
names: Similarity
messages: Belongs to the EFG1/PHD1/stuA family.

27291:SPAR B03710
gene id: 27291:SPAR_B03710
uniprot id: A0A8B8UM65
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

27291:SPAR G03200
gene id: 27291:SPAR_G03200
uniprot id: A0A8B8URN2
names: Similarity
messages: Belongs to the TEL2 family.

27291:SPAR D06180
gene id: 27291:SPAR_D06180
uniprot id: A0A8B8UPE2
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

27291:SPAR G01730
gene id: 27291:SPAR_G01730
uniprot id: A0A8B8UR83
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL12 family.

27291:SPAR L02360
gene id: 27291:SPAR_L02360
uniprot id: A0A8B8UW12
names: Similarity
messages: Belongs to the mitochondrion-specific ribosomal protein mS38 family.

27291:SPAR L04280
gene id: 27291:SPAR_L04280
uniprot id: A0A8B8UWK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize preautophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy.
messages: Belongs to the ATG17 family.
messages: Cytoplasm
messages: Membrane
messages: Preautophagosomal structure membrane

27291:SPAR E01260
gene id: 27291:SPAR_E01260
uniprot id: A0A8B8UQ31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR I01430
gene id: 27291:SPAR_I01430
uniprot id: A0A8B8UTH6
names: Similarity
messages: Belongs to the MNN1/MNT family.

27291:SPAR B03480
gene id: 27291:SPAR_B03480
uniprot id: A0A8B8UMG5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dUTPase family.
messages: Homotrimer.
messages: Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

27291:SPAR C00940
gene id: 27291:SPAR_C00940
uniprot id: A0A8B8UML5
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR F00100
gene id: 27291:SPAR_F00100
uniprot id: A0A8B8UQH7
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR E00330
gene id: 27291:SPAR_E00330
uniprot id: A0A8B8UQ32
names: Similarity
messages: Belongs to the glycosyl hydrolase 16 family.

27291:SPAR O00300
gene id: 27291:SPAR_O00300
uniprot id: A0A8B8UZ39
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.

27291:SPAR G01530
gene id: 27291:SPAR_G01530
uniprot id: A0A8B8UR60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin GLFG family.
messages: Nucleus membrane
messages: nuclear pore complex

27291:SPAR H02030
gene id: 27291:SPAR_H02030
uniprot id: A0A8B8USR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR H00410
gene id: 27291:SPAR_H00410
uniprot id: A0A8B8USE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OSBP family.
messages: Membrane

27291:SPAR P03880
gene id: 27291:SPAR_P03880
uniprot id: A0A8B8V1J0
names: Similarity
messages: Belongs to the CBF/MAK21 family.

27291:SPAR B03840
gene id: 27291:SPAR_B03840
uniprot id: A0A8B8UM93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF5 family.
messages: Nucleus

27291:SPAR H01600
gene id: 27291:SPAR_H01600
uniprot id: A0A8B8USS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC6 family.
messages: Nucleus

27291:SPAR F00620
gene id: 27291:SPAR_F00620
uniprot id: A0A8B8UQW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: nuclear pore complex

27291:SPAR D01730
gene id: 27291:SPAR_D01730
uniprot id: A0A8B8UNH5
names: Subcellular Location Annotation
messages: nucleolus

27291:SPAR O02750
gene id: 27291:SPAR_O02750
uniprot id: A0A8B8UZT4
names: Subcellular Location Annotation
messages: nucleolus

27291:SPAR J02070
gene id: 27291:SPAR_J02070
uniprot id: A0A8B8UU42
names: Similarity
messages: Belongs to the IlvD/Edd family.

27291:SPAR J00980
gene id: 27291:SPAR_J00980
uniprot id: A0A8B8UTW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HEATR1/UTP10 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

27291:SPAR D01360
gene id: 27291:SPAR_D01360
uniprot id: A0A8B8UN29
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.

27291:SPAR L02840
gene id: 27291:SPAR_L02840
uniprot id: A0A8B8UWA7
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

27291:SPAR O03360
gene id: 27291:SPAR_O03360
uniprot id: A0A8B8UZZ7
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR K00600
gene id: 27291:SPAR_K00600
uniprot id: A0A8B8UUN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELOF1 family.
messages: Nucleus
messages: Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.

27291:SPAR F00270
gene id: 27291:SPAR_F00270
uniprot id: A0A8B8UQT0
names: Function
names: Similarity
messages: Belongs to the phage and mitochondrial RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

27291:SPAR B01800
gene id: 27291:SPAR_B01800
uniprot id: A0A8B8ULN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPS2 family.
messages: Cell membrane
messages: Membrane

27291:SPAR L00410
gene id: 27291:SPAR_L00410
uniprot id: A0A8B8UVG7
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.

27291:SPAR G02230
gene id: 27291:SPAR_G02230
uniprot id: A0A8B8URD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

27291:SPAR E00150
gene id: 27291:SPAR_E00150
uniprot id: A0A8B8UPS8
names: Similarity
messages: Belongs to the peptidase S8 family.

27291:SPAR D01780
gene id: 27291:SPAR_D01780
uniprot id: A0A8B8UNI0
names: Function
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.
messages: Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.

27291:SPAR D02540
gene id: 27291:SPAR_D02540
uniprot id: A0A8B8UNE7
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR J00990
gene id: 27291:SPAR_J00990
uniprot id: A0A8B8UTU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThrE exporter (TC 2.A.79) family.
messages: Membrane

27291:SPAR G02350
gene id: 27291:SPAR_G02350
uniprot id: A0A8B8URE8
names: Similarity
messages: Belongs to the cullin family.

27291:SPAR J00050
gene id: 27291:SPAR_J00050
uniprot id: A0A8B8UTI0
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

27291:SPAR K00720
gene id: 27291:SPAR_K00720
uniprot id: A0A8B8UUP5
names: Similarity
messages: Belongs to the AAA ATPase family.

27291:SPAR J01850
gene id: 27291:SPAR_J01850
uniprot id: A0A8B8UU25
names: Function
names: Similarity
messages: Belongs to the adenylyl cyclase class-3 family.
messages: Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.

27291:SPAR P00910
gene id: 27291:SPAR_P00910
uniprot id: A0A8B8V0T9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

27291:SPAR K00290
gene id: 27291:SPAR_K00290
uniprot id: A0A8B8UUJ9
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

27291:SPAR P00450
gene id: 27291:SPAR_P00450
uniprot id: A0A8B8V0K6
names: Similarity
messages: Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.

27291:SPAR G02070
gene id: 27291:SPAR_G02070
uniprot id: A0A8B8URG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 17 family.
messages: cell wall

27291:SPAR L03170
gene id: 27291:SPAR_L03170
uniprot id: A0A8B8UWG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the U1 small nuclear ribonucleoprotein C family.
messages: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
messages: Nucleus
messages: U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.

27291:SPAR B00750
gene id: 27291:SPAR_B00750
uniprot id: A0A8B8ULD2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Monomer.

27291:SPAR G00170
gene id: 27291:SPAR_G00170
uniprot id: A0A8B8UQW5
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.

27291:SPAR N03050
gene id: 27291:SPAR_N03050
uniprot id: A0A8B8UYU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

27291:SPAR G00710
gene id: 27291:SPAR_G00710
uniprot id: A0A8B8UR27
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

27291:SPAR B02580
gene id: 27291:SPAR_B02580
uniprot id: A0A8B8UM76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.
messages: Endoplasmic reticulum membrane
messages: Interacts with the fatty acid elongation system components ELO3 and TSC13.

27291:SPAR P04160
gene id: 27291:SPAR_P04160
uniprot id: A0A8B8V1S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Membrane

27291:SPAR M01240
gene id: 27291:SPAR_M01240
uniprot id: A0A8B8UX78
names: Similarity
messages: Belongs to the UPF0507 family.

27291:SPAR O00520
gene id: 27291:SPAR_O00520
uniprot id: A0A8B8UZB4
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.

27291:SPAR J01780
gene id: 27291:SPAR_J01780
uniprot id: A0A8B8UU54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.

27291:SPAR B00850
gene id: 27291:SPAR_B00850
uniprot id: A0A8B8ULE4
names: Similarity
messages: Belongs to the NFYB/HAP3 subunit family.

27291:SPAR N00310
gene id: 27291:SPAR_N00310
uniprot id: A0A8B8UY23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

27291:SPAR I01380
gene id: 27291:SPAR_I01380
uniprot id: A0A8B8UQN0
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

27291:SPAR D04230
gene id: 27291:SPAR_D04230
uniprot id: A0A8B8UP76
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

27291:SPAR J01570
gene id: 27291:SPAR_J01570
uniprot id: A0A8B8UU00
names: Similarity
messages: Belongs to the NUP186/NUP192/NUP205 family.

27291:SPAR G02220
gene id: 27291:SPAR_G02220
uniprot id: A0A8B8URH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

27291:SPAR J02610
gene id: 27291:SPAR_J02610
uniprot id: A0A8B8UUF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EAF6 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
messages: Component of the NuA4 histone acetyltransferase complex.
messages: Nucleus

27291:SPAR B02170
gene id: 27291:SPAR_B02170
uniprot id: A0A8B8ULN4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

27291:SPAR A00500
gene id: 27291:SPAR_A00500
uniprot id: A0A8B8UL09
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nth/MutY family.
messages: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion
messages: Nucleus

27291:SPAR C00980
gene id: 27291:SPAR_C00980
uniprot id: A0A8B8UMG8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PGAP3 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the lipid remodeling steps of GPI-anchor maturation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

27291:SPAR P03870
gene id: 27291:SPAR_P03870
uniprot id: A0A8B8V1J2
names: Similarity
messages: Belongs to the RRP15 family.

27291:SPAR H00700
gene id: 27291:SPAR_H00700
uniprot id: A0A8B8USH8
names: Similarity
messages: Belongs to the peptidase S9B family.

27291:SPAR B00210
gene id: 27291:SPAR_B00210
uniprot id: A0A8B8UL59
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
messages: Cytoplasm

27291:SPAR D02620
gene id: 27291:SPAR_D02620
uniprot id: A0A8B8UND5
names: Similarity
names: Subunit
messages: Belongs to the aerobic coproporphyrinogen-III oxidase family.
messages: Homodimer.

27291:SPAR P02340
gene id: 27291:SPAR_P02340
uniprot id: A0A8B8V183
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.
messages: Belongs to the TRM44 family.
messages: Cytoplasm

27291:SPAR H01510
gene id: 27291:SPAR_H01510
uniprot id: A0A8B8USQ9
names: Similarity
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.

27291:SPAR M02430
gene id: 27291:SPAR_M02430
uniprot id: A0A8B8UXD4
names: Similarity
messages: Belongs to the MYST (SAS/MOZ) family.

27291:SPAR P03990
gene id: 27291:SPAR_P03990
uniprot id: A0A8B8V1Q9
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR P00720
gene id: 27291:SPAR_P00720
uniprot id: A0A8B8V0M7
names: Similarity
messages: Belongs to the protein kinase superfamily.

27291:SPAR B00900
gene id: 27291:SPAR_B00900
uniprot id: A0A8B8ULE9
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

27291:SPAR B02640
gene id: 27291:SPAR_B02640
uniprot id: A0A8B8ULX1
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

27291:SPAR D01720
gene id: 27291:SPAR_D01720
uniprot id: A0A8B8UN45
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

27291:SPAR O01110
gene id: 27291:SPAR_O01110
uniprot id: A0A8B8UZC7
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.

27291:SPAR G02150
gene id: 27291:SPAR_G02150
uniprot id: A0A8B8URD1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Regulatory subunit of casein kinase II/CK2 (By similarity). As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
messages: Tetramer of two alpha and two beta subunits.

27291:SPAR B01410
gene id: 27291:SPAR_B01410
uniprot id: A0A8B8ULJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chitin synthase family.
messages: Cell membrane
messages: Membrane
messages: Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.

27291:SPAR O00280
gene id: 27291:SPAR_O00280
uniprot id: A0A8B8UZ41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

27291:SPAR N03270
gene id: 27291:SPAR_N03270
uniprot id: A0A8B8UYW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC12 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER.

27291:SPAR L03120
gene id: 27291:SPAR_L03120
uniprot id: A0A8B8UWF7
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

27291:SPAR N03560
gene id: 27291:SPAR_N03560
uniprot id: A0A8B8UZ45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF2/ABP1 family.
messages: nucleolus

27291:SPAR H00060
gene id: 27291:SPAR_H00060
uniprot id: A0A8B8USB2
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR E01940
gene id: 27291:SPAR_E01940
uniprot id: A0A8B8UQ92
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR N02010
gene id: 27291:SPAR_N02010
uniprot id: A0A8B8UYP1
names: Similarity
messages: Belongs to the DEAD box helicase family.

27291:SPAR B01950
gene id: 27291:SPAR_B01950
uniprot id: A0A8B8ULP9
names: Similarity
messages: Belongs to the histidine acid phosphatase family.

27291:SPAR L02830
gene id: 27291:SPAR_L02830
uniprot id: A0A8B8UW67
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

27291:SPAR D01850
gene id: 27291:SPAR_D01850
uniprot id: A0A8B8UN77
names: Similarity
messages: Belongs to the PPP phosphatase family.

27291:SPAR N01050
gene id: 27291:SPAR_N01050
uniprot id: A0A8B8UYE4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

27291:SPAR I01340
gene id: 27291:SPAR_I01340
uniprot id: A0A8B8UTE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tim44 family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion inner membrane

27291:SPAR L01230
gene id: 27291:SPAR_L01230
uniprot id: A0A8B8UVQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FYV7 family.
messages: Involved in the processing of the 20S pre-rRNA.
messages: nucleolus

27291:SPAR B03390
gene id: 27291:SPAR_B03390
uniprot id: A0A8B8UM46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR O02250
gene id: 27291:SPAR_O02250
uniprot id: A0A8B8UZN1
names: Similarity
messages: Belongs to the PP2C family.

27291:SPAR L01210
gene id: 27291:SPAR_L01210
uniprot id: A0A8B8UVQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS3 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR G04310
gene id: 27291:SPAR_G04310
uniprot id: A0A8B8US34
names: Similarity
messages: Belongs to the exportin family.

27291:SPAR I01240
gene id: 27291:SPAR_I01240
uniprot id: A0A8B8UTD6
names: Similarity
messages: Belongs to the protein kinase superfamily.

27291:SPAR P02460
gene id: 27291:SPAR_P02460
uniprot id: A0A8B8V188
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

27291:SPAR P02410
gene id: 27291:SPAR_P02410
uniprot id: A0A8B8V184
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPF family.
messages: Nucleus

27291:SPAR B02430
gene id: 27291:SPAR_B02430
uniprot id: A0A8B8UM61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm

27291:SPAR D06970
gene id: 27291:SPAR_D06970
uniprot id: A0A8B8UPN6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: GTPase-activating protein for the ADP ribosylation factor family.

27291:SPAR O00290
gene id: 27291:SPAR_O00290
uniprot id: A0A8B8UZ89
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

27291:SPAR M02100
gene id: 27291:SPAR_M02100
uniprot id: A0A8B8UXB6
names: Subcellular Location Annotation
messages: nucleolus

27291:SPAR O02900
gene id: 27291:SPAR_O02900
uniprot id: A0A8B8UZV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Membrane
messages: Probably involved in transport through the plasma membrane.

27291:SPAR J02500
gene id: 27291:SPAR_J02500
uniprot id: A0A8B8UU96
names: Similarity
messages: Belongs to the activator 1 small subunits family.

27291:SPAR H01480
gene id: 27291:SPAR_H01480
uniprot id: A0A8B8USU4
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

27291:SPAR P03440
gene id: 27291:SPAR_P03440
uniprot id: A0A8B8V1J8
names: Similarity
messages: Belongs to the PHF5 family.

27291:SPAR J00580
gene id: 27291:SPAR_J00580
uniprot id: A0A8B8UTT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S64 family.
messages: Cell membrane
messages: Component of the plasma membrane SPS (SSY1-PTR3-SSY5) amino acid sensor complex.
messages: Protease component of the SPS-sensor system, which regulates the expression of several amino acid-metabolizing enzymes and amino acid- and peptide-permeases in response to extracellular amino acid levels by controlling the activity of two transcription factors, STP1 and STP2. Catalyzes the activation of these transcription factors, which are synthesized as latent cytoplasmic precursors, by proteolytic removal of an N-terminal inhibitory domain containing cytoplasmic retention motifs. SSY5 binds as an inactive protease complex to STP1. In response to extracellular amino acids and dependent on the other SPS-sensor components, the inhibitory propeptide is induced to dissociate, and thereby enables the catalytic domain to process STP1.

27291:SPAR H00850
gene id: 27291:SPAR_H00850
uniprot id: A0A8B8USJ7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NADPH--cytochrome P450 reductase family.
messages: Binds 1 FAD per monomer.
messages: Binds 1 FMN per monomer.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion outer membrane
messages: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.

27291:SPAR E01460
gene id: 27291:SPAR_E01460
uniprot id: A0A8B8UQ50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDA2 family.
messages: Cell projection
messages: Cytoplasm

27291:SPAR O01700
gene id: 27291:SPAR_O01700
uniprot id: A0A8B8UZH8
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.

27291:SPAR P01390
gene id: 27291:SPAR_P01390
uniprot id: A0A8B8V0Z0
names: Function
names: Subcellular Location Annotation
messages: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.
messages: Mitochondrion inner membrane

27291:SPAR O03180
gene id: 27291:SPAR_O03180
uniprot id: A0A8B8UZX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

27291:SPAR M02780
gene id: 27291:SPAR_M02780
uniprot id: A0A8B8UXH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INP2 family.
messages: Membrane
messages: Peroxisome membrane

27291:SPAR G01850
gene id: 27291:SPAR_G01850
uniprot id: A0A8B8UR99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDS23 family.
messages: Cytoplasm
messages: Involved in DNA replication and cell separation.

27291:SPAR L02960
gene id: 27291:SPAR_L02960
uniprot id: A0A8B8UW76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND1 (condensin subunit 1) family.
messages: Chromosome
messages: Nucleus
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

27291:SPAR K02820
gene id: 27291:SPAR_K02820
uniprot id: A0A8B8UV96
names: Similarity
messages: Belongs to the RNase Z family.

27291:SPAR G02500
gene id: 27291:SPAR_G02500
uniprot id: A0A8B8URG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase F subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.
messages: Vacuole membrane

27291:SPAR L00090
gene id: 27291:SPAR_L00090
uniprot id: A0A8B8UVE1
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR O04450
gene id: 27291:SPAR_O04450
uniprot id: A0A8B8V0A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPA43 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

27291:SPAR G01140
gene id: 27291:SPAR_G01140
uniprot id: A0A8B8V0Q4
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

27291:SPAR N01890
gene id: 27291:SPAR_N01890
uniprot id: A0A8B8UYH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: microtubule organizing center

27291:SPAR E00120
gene id: 27291:SPAR_E00120
uniprot id: A0A8B8UPP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

27291:SPAR P02960
gene id: 27291:SPAR_P02960
uniprot id: A0A8B8V1D9
names: Similarity
messages: Belongs to the actin family.

27291:SPAR C00450
gene id: 27291:SPAR_C00450
uniprot id: A0A8B8UME7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Homodimer.

27291:SPAR J02180
gene id: 27291:SPAR_J02180
uniprot id: A0A8B8UU94
names: Similarity
messages: Belongs to the PET191 family.

27291:SPAR L01540
gene id: 27291:SPAR_L01540
uniprot id: A0A8B8UVS9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.

27291:SPAR P00090
gene id: 27291:SPAR_P00090
uniprot id: A0A8B8V0L3
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR O01970
gene id: 27291:SPAR_O01970
uniprot id: A0A8B8UZQ8
names: Similarity
messages: Belongs to the MAP65/ASE1 family.

27291:SPAR P04130
gene id: 27291:SPAR_P04130
uniprot id: A0A8B8V1L6
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR M00400
gene id: 27291:SPAR_M00400
uniprot id: A0A8B8UWT3
names: Subcellular Location Annotation
messages: nucleolus

27291:SPAR G03590
gene id: 27291:SPAR_G03590
uniprot id: A0A8B8US24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKN1/KRE6 family.
messages: Membrane

27291:SPAR P00630
gene id: 27291:SPAR_P00630
uniprot id: A0A8B8V0L5
names: Similarity
messages: Belongs to the U2 small nuclear ribonucleoprotein A family.

27291:SPAR B00910
gene id: 27291:SPAR_B00910
uniprot id: A0A8B8ULE1
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

27291:SPAR K00830
gene id: 27291:SPAR_K00830
uniprot id: A0A8B8UUV8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.
messages: Mitochondrion matrix

27291:SPAR G02260
gene id: 27291:SPAR_G02260
uniprot id: A0A8B8URI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.
messages: Cell membrane
messages: The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.

27291:SPAR G01100
gene id: 27291:SPAR_G01100
uniprot id: A0A8B8UR28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor potential (TRP) ion channel family.
messages: Membrane

27291:SPAR N00840
gene id: 27291:SPAR_N00840
uniprot id: A0A8B8UY76
names: Similarity
messages: Belongs to the SUI1 family.

27291:SPAR B03380
gene id: 27291:SPAR_B03380
uniprot id: A0A8B8UMF9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HDDC2 family.
messages: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
messages: Homodimer.

27291:SPAR D02370
gene id: 27291:SPAR_D02370
uniprot id: A0A8B8UNB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex DAD1 family.
messages: Nucleus
messages: kinetochore
messages: spindle

27291:SPAR C00830
gene id: 27291:SPAR_C00830
uniprot id: A0A8B8UMF2
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR J00070
gene id: 27291:SPAR_J00070
uniprot id: A0A8B8UTI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR N00510
gene id: 27291:SPAR_N00510
uniprot id: A0A8B8UY42
names: Similarity
messages: Belongs to the AHA1 family.

27291:SPAR K00190
gene id: 27291:SPAR_K00190
uniprot id: A0A8B8UUI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.

27291:SPAR G01800
gene id: 27291:SPAR_G01800
uniprot id: A0A8B8UR96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex DUO1 family.
messages: Nucleus
messages: kinetochore

27291:SPAR D01260
gene id: 27291:SPAR_D01260
uniprot id: A0A8B8UN19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

27291:SPAR P03400
gene id: 27291:SPAR_P03400
uniprot id: A0A8B8V1F6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: srp72, srp68, srp54, sec65, srp21 and srp14.
messages: Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes. SRP54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit SRP101. Both, SRP54 and SRP101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon). After signal sequence transfer, SRP54 and SRP101 act as reciprocal GTPase-activating proteins (GAPs), thereby resolving their association.
messages: The M domain binds the 7SL RNA and the signal sequence of presecretory proteins.
messages: The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit srp101. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

27291:SPAR F00660
gene id: 27291:SPAR_F00660
uniprot id: A0A8B8UQK3
names: Similarity
messages: Belongs to the peptidase M24B family.

27291:SPAR N01900
gene id: 27291:SPAR_N01900
uniprot id: A0A8B8UYI2
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR O00830
gene id: 27291:SPAR_O00830
uniprot id: A0A8B8UZ95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NUF2 family.
messages: kinetochore

27291:SPAR O01400
gene id: 27291:SPAR_O01400
uniprot id: A0A8B8UZE8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

27291:SPAR J00240
gene id: 27291:SPAR_J00240
uniprot id: A0A8B8UTM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

27291:SPAR B03760
gene id: 27291:SPAR_B03760
uniprot id: A0A8B8UM73
names: Similarity
messages: Belongs to the peptidase M20A family.

27291:SPAR D02590
gene id: 27291:SPAR_D02590
uniprot id: A0A8B8UNF2
names: Similarity
messages: Belongs to the universal ribosomal protein uS10 family.

27291:SPAR F01040
gene id: 27291:SPAR_F01040
uniprot id: A0A8B8UQU0
names: Function
names: Similarity
messages: Belongs to the IRC6 family.
messages: Involved in gross chromosomal rearrangements (GCRs) and telomere healing.

27291:SPAR B03430
gene id: 27291:SPAR_B03430
uniprot id: A0A8B8UMG3
names: Similarity
messages: Belongs to the bystin family.

27291:SPAR E00250
gene id: 27291:SPAR_E00250
uniprot id: A0A8B8UPT8
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

27291:SPAR O02100
gene id: 27291:SPAR_O02100
uniprot id: A0A8B8UZL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: centromere

27291:SPAR L01260
gene id: 27291:SPAR_L01260
uniprot id: A0A8B8UVQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 14 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

27291:SPAR G01900
gene id: 27291:SPAR_G01900
uniprot id: A0A8B8URA4
names: Similarity
messages: Belongs to the AAA ATPase family.

27291:SPAR B00970
gene id: 27291:SPAR_B00970
uniprot id: A0A8B8ULA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

27291:SPAR N01770
gene id: 27291:SPAR_N01770
uniprot id: A0A8B8UYG6
names: Similarity
messages: Belongs to the CAP family.

27291:SPAR F00750
gene id: 27291:SPAR_F00750
uniprot id: A0A8B8UQQ5
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 3 family.
messages: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.

27291:SPAR J03000
gene id: 27291:SPAR_J03000
uniprot id: A0A1L4AA74
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

27291:SPAR M01660
gene id: 27291:SPAR_M01660
uniprot id: A0A8B8UXA5
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR C01140
gene id: 27291:SPAR_C01140
uniprot id: A0A8B8UMW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC12 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER.

27291:SPAR D02030
gene id: 27291:SPAR_D02030
uniprot id: A0A8B8UNK2
names: Similarity
messages: Belongs to the histidine acid phosphatase family.

27291:SPAR K00010
gene id: 27291:SPAR_K00010
uniprot id: A0A8B8USX0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

27291:SPAR M02700
gene id: 27291:SPAR_M02700
uniprot id: A0A8B8UXH3
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR D00460
gene id: 27291:SPAR_D00460
uniprot id: A0A8B8UMT8
names: Similarity
messages: Belongs to the MGMT family.

27291:SPAR P03220
gene id: 27291:SPAR_P03220
uniprot id: A0A8B8V1C8
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.
messages: Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.

27291:SPAR J03160
gene id: 27291:SPAR_J03160
uniprot id: A0A8B8UUK8
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

27291:SPAR L02940
gene id: 27291:SPAR_L02940
uniprot id: A0A8B8UWB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HIT family.
messages: Cytoplasm

27291:SPAR M01710
gene id: 27291:SPAR_M01710
uniprot id: A0A8B8UXA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat BOP1/ERB1 family.
messages: Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.
messages: Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

27291:SPAR M01900
gene id: 27291:SPAR_M01900
uniprot id: A0A8B8UX88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP18 family.
messages: Golgi apparatus membrane
messages: Golgi membrane protein involved in vesicular trafficking.
messages: Membrane

27291:SPAR M04120
gene id: 27291:SPAR_M04120
uniprot id: A0A8B8UXV2
names: Similarity
messages: Belongs to the peptidase S10 family.

27291:SPAR K01920
gene id: 27291:SPAR_K01920
uniprot id: A0A8B8UV09
names: Similarity
messages: Belongs to the DNA2/NAM7 helicase family.

27291:SPAR M04250
gene id: 27291:SPAR_M04250
uniprot id: A0A8B8UXX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit C family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

27291:SPAR P01760
gene id: 27291:SPAR_P01760
uniprot id: A0A8B8V121
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC62 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR G03030
gene id: 27291:SPAR_G03030
uniprot id: A0A8B8URL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

27291:SPAR N03600
gene id: 27291:SPAR_N03600
uniprot id: A0A8B8UYZ8
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

27291:SPAR D03040
gene id: 27291:SPAR_D03040
uniprot id: A0A8B8UNK0
names: Similarity
messages: Belongs to the RRP1 family.

27291:SPAR E01480
gene id: 27291:SPAR_E01480
uniprot id: A0A8B8UQE0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

27291:SPAR L03600
gene id: 27291:SPAR_L03600
uniprot id: A0A8B8UWE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the importin beta family. Importin beta-1 subfamily.
messages: Cytoplasm

27291:SPAR H01180
gene id: 27291:SPAR_H01180
uniprot id: A0A8B8USR8
names: Similarity
messages: Belongs to the PP2C family.

27291:SPAR L02150
gene id: 27291:SPAR_L02150
uniprot id: A0A8B8UVZ3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

27291:SPAR E00140
gene id: 27291:SPAR_E00140
uniprot id: A0A8B8UPQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.
messages: spindle

27291:SPAR N02650
gene id: 27291:SPAR_N02650
uniprot id: A0A8B8UYQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.
messages: Belongs to the COG6 family.
messages: Component of the conserved oligomeric Golgi complex.
messages: Golgi apparatus membrane
messages: Membrane

27291:SPAR E01450
gene id: 27291:SPAR_E01450
uniprot id: A0A8B8UQ54
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

27291:SPAR N02580
gene id: 27291:SPAR_N02580
uniprot id: A0A8B8UYU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: Cytoplasm

27291:SPAR G00900
gene id: 27291:SPAR_G00900
uniprot id: A0A8B8UR08
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

27291:SPAR B00480
gene id: 27291:SPAR_B00480
uniprot id: A0A8B8ULM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM11 family.
messages: Membrane

27291:SPAR L04380
gene id: 27291:SPAR_L04380
uniprot id: A0A8B8UWL8
names: Similarity
messages: Belongs to the TSR2 family.

27291:SPAR C00120
gene id: 27291:SPAR_C00120
uniprot id: A0A8B8UMA5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

27291:SPAR P03830
gene id: 27291:SPAR_P03830
uniprot id: A0A8B8V1I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

27291:SPAR O00880
gene id: 27291:SPAR_O00880
uniprot id: A0A8B8UZA0
names: Function
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.
messages: Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP.

27291:SPAR P03080
gene id: 27291:SPAR_P03080
uniprot id: A0A8B8V1B2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: In the N-terminal section; belongs to the flavodoxin family.
messages: Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion
messages: NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.

27291:SPAR P03510
gene id: 27291:SPAR_P03510
uniprot id: A0A8B8V1J6
names: Subunit
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

27291:SPAR M02950
gene id: 27291:SPAR_M02950
uniprot id: A0A8B8UXJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fungal TPase family.
messages: First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.
messages: Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.
messages: Nucleus

27291:SPAR N00410
gene id: 27291:SPAR_N00410
uniprot id: A0A8B8UY32
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

27291:SPAR F00140
gene id: 27291:SPAR_F00140
uniprot id: A0A8B8UQJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

27291:SPAR L02740
gene id: 27291:SPAR_L02740
uniprot id: A0A8B8UW97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

27291:SPAR I00240
gene id: 27291:SPAR_I00240
uniprot id: A0A8B8UT39
names: Similarity
messages: Belongs to the pantothenate synthetase family.

27291:SPAR O02090
gene id: 27291:SPAR_O02090
uniprot id: A0A8B8UZR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

27291:SPAR I01210
gene id: 27291:SPAR_I01210
uniprot id: A0A8B8UTH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT2/3/5 family.
messages: Nucleus

27291:SPAR N00450
gene id: 27291:SPAR_N00450
uniprot id: A0A8B8UY83
names: Similarity
messages: Belongs to the CNOT9 family.

27291:SPAR M03260
gene id: 27291:SPAR_M03260
uniprot id: A0A8B8UXR6
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

27291:SPAR M01570
gene id: 27291:SPAR_M01570
uniprot id: A0A8B8UX49
names: Similarity
messages: Belongs to the actin family.

27291:SPAR P01400
gene id: 27291:SPAR_P01400
uniprot id: A0A8B8V0V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

27291:SPAR G00510
gene id: 27291:SPAR_G00510
uniprot id: A0A8B8UR04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Component of the FACT complex.
messages: Nucleus

27291:SPAR I01890
gene id: 27291:SPAR_I01890
uniprot id: A0A8B8UTJ6
names: Similarity
names: Subunit
messages: Belongs to the AlaDH/PNT family.
messages: Monomer.

27291:SPAR N03140
gene id: 27291:SPAR_N03140
uniprot id: A0A8B8UYU8
names: Similarity
messages: Belongs to the uridine kinase family.

27291:SPAR O00530
gene id: 27291:SPAR_O00530
uniprot id: A0A8B8UZ65
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR M01460
gene id: 27291:SPAR_M01460
uniprot id: A0A8B8UX92
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

27291:SPAR M02010
gene id: 27291:SPAR_M02010
uniprot id: A0A8B8UXD6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

27291:SPAR D05460
gene id: 27291:SPAR_D05460
uniprot id: A0A8B8UP85
names: Function
names: Similarity
messages: Belongs to the BLOC1S4 family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting.

27291:SPAR N02630
gene id: 27291:SPAR_N02630
uniprot id: A0A8B8UYU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA1 family.
messages: Membrane

27291:SPAR N00560
gene id: 27291:SPAR_N00560
uniprot id: A0A8B8UY47
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR J01900
gene id: 27291:SPAR_J01900
uniprot id: A0A8B8UU34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Vacuole membrane

27291:SPAR A00570
gene id: 27291:SPAR_A00570
uniprot id: A0A8B8UKU6
names: Similarity
messages: Belongs to the FUN14 family.

27291:SPAR C01360
gene id: 27291:SPAR_C01360
uniprot id: A0A8B8UMM7
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).

27291:SPAR N00890
gene id: 27291:SPAR_N00890
uniprot id: A0A8B8UY80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Cytoplasm
messages: Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.
messages: Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.
messages: Mitochondrion
messages: The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.

27291:SPAR P01790
gene id: 27291:SPAR_P01790
uniprot id: A0A8B8V130
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: Maintains high levels of reduced glutathione in the cytosol.

27291:SPAR N00290
gene id: 27291:SPAR_N00290
uniprot id: A0A8B8UY19
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

27291:SPAR K00670
gene id: 27291:SPAR_K00670
uniprot id: A0A8B8UUN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Cytoplasm

27291:SPAR J01380
gene id: 27291:SPAR_J01380
uniprot id: A0A8B8UU14
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL17 family.

27291:SPAR B01200
gene id: 27291:SPAR_B01200
uniprot id: A0A8B8ULH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYSTM1 family.
messages: Membrane

27291:SPAR L03700
gene id: 27291:SPAR_L03700
uniprot id: A0A8B8UWF0
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

27291:SPAR G04500
gene id: 27291:SPAR_G04500
uniprot id: A0A8B8US14
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Heterooctamer of 4 alpha and 4 beta chains.

27291:SPAR O04080
gene id: 27291:SPAR_O04080
uniprot id: A0A8B8V069
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CybS family.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR P03120
gene id: 27291:SPAR_P03120
uniprot id: A0A8B8V1B9
names: Similarity
messages: Belongs to the protein kinase superfamily.

27291:SPAR D00550
gene id: 27291:SPAR_D00550
uniprot id: A0A8B8UMU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm

27291:SPAR P01270
gene id: 27291:SPAR_P01270
uniprot id: A0A8B8V0T2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP53 family.
messages: May play a role in ribosome biogenesis.
messages: nucleolus
messages: nucleoplasm

27291:SPAR D03640
gene id: 27291:SPAR_D03640
uniprot id: A0A8B8UNQ7
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Homodimer.

27291:SPAR P01980
gene id: 27291:SPAR_P01980
uniprot id: A0A8B8V104
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

27291:SPAR E00710
gene id: 27291:SPAR_E00710
uniprot id: A0A8B8UPX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP16 family.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

27291:SPAR D01330
gene id: 27291:SPAR_D01330
uniprot id: A0A8B8UND4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homodimer.
messages: Mitochondrion
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.

27291:SPAR J03210
gene id: 27291:SPAR_J03210
uniprot id: A0A8B8UUL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGM101 family.
messages: mitochondrion nucleoid

27291:SPAR F01100
gene id: 27291:SPAR_F01100
uniprot id: A0A8B8UQT9
names: Subcellular Location Annotation
messages: Mitochondrion

27291:SPAR B02090
gene id: 27291:SPAR_B02090
uniprot id: A0A8B8ULR3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AIM3 family.
messages: Interacts with RVS167.
messages: Membrane raft

27291:SPAR B02130
gene id: 27291:SPAR_B02130
uniprot id: A0A8B8UM34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ENY2 family.
messages: Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least SUS1, SAC3, THP1, SEM1, and CDC31. TREX-2 contains 2 SUS1 chains. The TREX-2 complex interacts with the nucleoporin NUP1. Component of the 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5 distinct domains with specialized functions. Within the SAGA complex, SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with THP1, SAC3, SGF11, and with the RNA polymerase II.
messages: Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. May also be involved in cytoplasmic mRNA decay by interaction with components of P-bodies.
messages: P-body
messages: nucleoplasm

27291:SPAR D05800
gene id: 27291:SPAR_D05800
uniprot id: A0A8B8UPC8
names: Similarity
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family.
messages: Heterodimer.

27291:SPAR H02040
gene id: 27291:SPAR_H02040
uniprot id: A0A8B8UT04
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.

27291:SPAR D03620
gene id: 27291:SPAR_D03620
uniprot id: A0A8B8UNN7
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

27291:SPAR N01190
gene id: 27291:SPAR_N01190
uniprot id: A0A8B8UYB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RTT106 family.
messages: Chromosome
messages: Nucleus

27291:SPAR A00850
gene id: 27291:SPAR_A00850
uniprot id: A0A8B8UL37
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

27291:SPAR D00790
gene id: 27291:SPAR_D00790
uniprot id: A0A8B8UMX5
names: Similarity
messages: Belongs to the epsin family.

27291:SPAR H01170
gene id: 27291:SPAR_H01170
uniprot id: A0A8B8USI6
names: Function
names: Similarity
messages: Belongs to the AB hydrolase superfamily.
messages: Demethylates proteins that have been reversibly carboxymethylated.

27291:SPAR B03490
gene id: 27291:SPAR_B03490
uniprot id: A0A8B8UM58
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 22 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

27291:SPAR H00720
gene id: 27291:SPAR_H00720
uniprot id: A0A8B8USE0
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

27291:SPAR M00200
gene id: 27291:SPAR_M00200
uniprot id: A0A8B8UWR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF8 family.
messages: Nucleus

27291:SPAR E00320
gene id: 27291:SPAR_E00320
uniprot id: A0A8B8UPS2
names: Similarity
messages: Belongs to the NAD kinase family.

27291:SPAR O00630
gene id: 27291:SPAR_O00630
uniprot id: A0A8B8UZ75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).
messages: Nucleus

27291:SPAR O03880
gene id: 27291:SPAR_O03880
uniprot id: A0A8B8V051
names: Function
names: Similarity
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37.

27291:SPAR G01680
gene id: 27291:SPAR_G01680
uniprot id: A0A8B8UR76
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

27291:SPAR H00890
gene id: 27291:SPAR_H00890
uniprot id: A0A8B8USH2
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

27291:SPAR C01070
gene id: 27291:SPAR_C01070
uniprot id: A0A8B8UMJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PWP2 family.
messages: nucleolus

27291:SPAR D04150
gene id: 27291:SPAR_D04150
uniprot id: A0A8B8UNV6
names: Similarity
messages: Belongs to the AHA1 family.

27291:SPAR D02630
gene id: 27291:SPAR_D02630
uniprot id: A0A8B8UNR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

27291:SPAR O01130
gene id: 27291:SPAR_O01130
uniprot id: A0A8B8UZC3
names: Function
names: Similarity
messages: Belongs to the peptidase T1A family.
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

27291:SPAR E00220
gene id: 27291:SPAR_E00220
uniprot id: A0A8B8UPR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAK10 family.
messages: Cytoplasm

27291:SPAR D03990
gene id: 27291:SPAR_D03990
uniprot id: A0A8B8UNU0
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

27291:SPAR K00400
gene id: 27291:SPAR_K00400
uniprot id: A0A8B8UUL5
names: Function
names: Similarity
messages: 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

27291:SPAR J02300
gene id: 27291:SPAR_J02300
uniprot id: A0A8B8UU75
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space

27291:SPAR L01780
gene id: 27291:SPAR_L01780
uniprot id: A0A8B8UVV3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

27291:SPAR D02230
gene id: 27291:SPAR_D02230
uniprot id: A0A8B8UNM5
names: Similarity
messages: Belongs to the RMD1/sif2 family.

27291:SPAR O03780
gene id: 27291:SPAR_O03780
uniprot id: A0A8B8V039
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

27291:SPAR B03830
gene id: 27291:SPAR_B03830
uniprot id: A0A8B8UMJ9
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

27291:SPAR E00920
gene id: 27291:SPAR_E00920
uniprot id: A0A8B8UPY4
names: Similarity
messages: Belongs to the proteasome subunit S3 family.

27291:SPAR D00810
gene id: 27291:SPAR_D00810
uniprot id: A0A8B8UMX6
names: Similarity
messages: Belongs to the DEAD box helicase family.

27291:SPAR G00520
gene id: 27291:SPAR_G00520
uniprot id: A0A8B8UR02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin heavy chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: coated pit

27291:SPAR O02270
gene id: 27291:SPAR_O02270
uniprot id: A0A8B8UZT7
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR I01870
gene id: 27291:SPAR_I01870
uniprot id: A0A8B8UTH0
names: Subunit
messages: Homodimer.

27291:SPAR E02500
gene id: 27291:SPAR_E02500
uniprot id: A0A8B8UQH8
names: Similarity
messages: Belongs to the DNA2/NAM7 helicase family.

27291:SPAR L02090
gene id: 27291:SPAR_L02090
uniprot id: A0A8B8UW36
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

27291:SPAR O04700
gene id: 27291:SPAR_O04700
uniprot id: A0A8B8V0D3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS12 family.

27291:SPAR C01210
gene id: 27291:SPAR_C01210
uniprot id: A0A8B8UML3
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR D06790
gene id: 27291:SPAR_D06790
uniprot id: A0A8B8UPW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

27291:SPAR D01790
gene id: 27291:SPAR_D01790
uniprot id: A0A8B8UN73
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR D03870
gene id: 27291:SPAR_D03870
uniprot id: A0A8B8UNQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCC2/Nipped-B family.
messages: Nucleus

27291:SPAR M03890
gene id: 27291:SPAR_M03890
uniprot id: A0A8B8UXY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U48 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR G02860
gene id: 27291:SPAR_G02860
uniprot id: A0A8B8URN9
names: Similarity
messages: In the N-terminal section; belongs to the FGAMS family.

27291:SPAR B02010
gene id: 27291:SPAR_B02010
uniprot id: A0A8B8ULP8
names: Similarity
messages: Belongs to the EME1/MMS4 family.

27291:SPAR K01190
gene id: 27291:SPAR_K01190
uniprot id: A0A8B8UUU0
names: Similarity
messages: Belongs to the ISF1/MBR1 family.

27291:SPAR J02570
gene id: 27291:SPAR_J02570
uniprot id: A0A8B8UU93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck

27291:SPAR P00560
gene id: 27291:SPAR_P00560
uniprot id: A0A8B8V0Q4
names: Similarity
messages: Belongs to the universal ribosomal protein uL1 family.

27291:SPAR A00590
gene id: 27291:SPAR_A00590
uniprot id: A0A8B8UL04
names: Similarity
messages: Belongs to the heat shock protein 70 family.

27291:SPAR J02560
gene id: 27291:SPAR_J02560
uniprot id: A0A8B8UUE8
names: Similarity
messages: Belongs to the glycosyltransferase 32 family.

27291:SPAR L01710
gene id: 27291:SPAR_L01710
uniprot id: A0A8B8UVU7
names: Similarity
messages: Belongs to the peptidase A1 family.

27291:SPAR G02560
gene id: 27291:SPAR_G02560
uniprot id: A0A8B8URL2
names: Similarity
messages: Belongs to the AAA ATPase family.

27291:SPAR J02510
gene id: 27291:SPAR_J02510
uniprot id: A0A8B8UUE3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and 5-bromodeoxyuridine 5'-triphosphate (BrdUTP) to their respective monophosphate derivatives. Xanthosine 5'-triphosphate (XTP) is also a potential substrate. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

27291:SPAR G01450
gene id: 27291:SPAR_G01450
uniprot id: A0A8B8UR63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Membrane
messages: nuclear pore complex

27291:SPAR J02600
gene id: 27291:SPAR_J02600
uniprot id: A0A8B8UUA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM24 family.
messages: Mitochondrion

27291:SPAR L04090
gene id: 27291:SPAR_L04090
uniprot id: A0A8B8UWN1
names: Function
names: Similarity
messages: Belongs to the dus family. Dus3 subfamily.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs.

27291:SPAR N03540
gene id: 27291:SPAR_N03540
uniprot id: A0A8B8UYY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

27291:SPAR H01550
gene id: 27291:SPAR_H01550
uniprot id: A0A8B8USS1
names: Similarity
messages: Belongs to the peptidase M18 family.

27291:SPAR P03100
gene id: 27291:SPAR_P03100
uniprot id: A0A8B8V1C6
names: Similarity
messages: Belongs to the acetyltransferase family. MAK3 subfamily.

27291:SPAR L01830
gene id: 27291:SPAR_L01830
uniprot id: A0A8B8UVV8
names: Similarity
messages: Belongs to the SLX4 family.

27291:SPAR P00310
gene id: 27291:SPAR_P00310
uniprot id: A0A8B8V0M8
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR D05060
gene id: 27291:SPAR_D05060
uniprot id: A0A8B8UP46
names: Domain
names: Function
names: Similarity
messages: Belongs to the IPK1 type 1 family.
messages: Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.
messages: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
messages: The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

27291:SPAR B00640
gene id: 27291:SPAR_B00640
uniprot id: A0A8B8ULB2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

27291:SPAR C00350
gene id: 27291:SPAR_C00350
uniprot id: A0A8B8UMD6
names: Similarity
messages: Belongs to the RRP7 family.

27291:SPAR K02440
gene id: 27291:SPAR_K02440
uniprot id: A0A8B8UV64
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleus

27291:SPAR L01010
gene id: 27291:SPAR_L01010
uniprot id: A0A8B8UVM7
names: Similarity
messages: Belongs to the lipid-translocating exporter (LTE) (TC 9.A.26.1) family.

27291:SPAR E01650
gene id: 27291:SPAR_E01650
uniprot id: A0A8B8UQ74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR H00500
gene id: 27291:SPAR_H00500
uniprot id: A0A8B8USG1
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

27291:SPAR H01160
gene id: 27291:SPAR_H01160
uniprot id: A0A8B8USM3
names: Similarity
messages: In the C-terminal section; belongs to the NAD synthetase family.

27291:SPAR D06750
gene id: 27291:SPAR_D06750
uniprot id: A0A8B8UPL0
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR K02920
gene id: 27291:SPAR_K02920
uniprot id: A0A8B8UVA8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

27291:SPAR O02300
gene id: 27291:SPAR_O02300
uniprot id: A0A8B8UZN6
names: Similarity
messages: Belongs to the ribose 5-phosphate isomerase family.

27291:SPAR O01360
gene id: 27291:SPAR_O01360
uniprot id: A0A8B8UZF2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

27291:SPAR G02170
gene id: 27291:SPAR_G02170
uniprot id: A0A8B8URH3
names: Similarity
messages: Belongs to the R-transferase family.

27291:SPAR B01270
gene id: 27291:SPAR_B01270
uniprot id: A0A8B8ULD9
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR D04600
gene id: 27291:SPAR_D04600
uniprot id: A0A8B8UP02
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

27291:SPAR D03270
gene id: 27291:SPAR_D03270
uniprot id: A0A8B8UNK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Mitochondrion

27291:SPAR I00170
gene id: 27291:SPAR_I00170
uniprot id: A0A8B8UT03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

27291:SPAR E00460
gene id: 27291:SPAR_E00460
uniprot id: A0A8B8UPU5
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Membrane
messages: Mitochondrion inner membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.

27291:SPAR H01490
gene id: 27291:SPAR_H01490
uniprot id: A0A8B8USN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck

27291:SPAR P04380
gene id: 27291:SPAR_P04380
uniprot id: A0A8B8V1P1
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR L01340
gene id: 27291:SPAR_L01340
uniprot id: A0A8B8UVR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR H02420
gene id: 27291:SPAR_H02420
uniprot id: A0A8B8UT00
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

27291:SPAR K01170
gene id: 27291:SPAR_K01170
uniprot id: A0A8B8UUT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC16 family. YJU2 subfamily.
messages: Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.
messages: Nucleus
messages: Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role (via N-terminus) in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. Further stabilizes spliceosome conformation for 3'-splice site docking (via C-terminus) promoting exon ligation.

27291:SPAR J02460
gene id: 27291:SPAR_J02460
uniprot id: A0A8B8UUD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.

27291:SPAR A00060
gene id: 27291:SPAR_A00060
uniprot id: A0A8B8UKT9
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

27291:SPAR E00360
gene id: 27291:SPAR_E00360
uniprot id: A0A8B8UPT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

27291:SPAR M01220
gene id: 27291:SPAR_M01220
uniprot id: A0A8B8UX11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.

27291:SPAR D00980
gene id: 27291:SPAR_D00980
uniprot id: A0A8B8UN99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

27291:SPAR N01180
gene id: 27291:SPAR_N01180
uniprot id: A0A8B8UYA4
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

27291:SPAR D03280
gene id: 27291:SPAR_D03280
uniprot id: A0A8B8UNY5
names: Similarity
messages: Belongs to the eIF2D family.

27291:SPAR K00730
gene id: 27291:SPAR_K00730
uniprot id: A0A8B8UUU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

27291:SPAR L04220
gene id: 27291:SPAR_L04220
uniprot id: A0A8B8UWR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS36 family.
messages: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).
messages: Cytoplasm
messages: Endosome

27291:SPAR K00760
gene id: 27291:SPAR_K00760
uniprot id: A0A8B8UUV1
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR C00720
gene id: 27291:SPAR_C00720
uniprot id: A0A8B8UMG1
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR K00890
gene id: 27291:SPAR_K00890
uniprot id: A0A8B8UUR0
names: Similarity
messages: Belongs to the phosphohexose mutase family.

27291:SPAR L02290
gene id: 27291:SPAR_L02290
uniprot id: A0A8B8UW52
names: Function
names: Similarity
names: Subunit
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.
messages: Monomer.

27291:SPAR B03170
gene id: 27291:SPAR_B03170
uniprot id: A0A8B8ULY4
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR G02140
gene id: 27291:SPAR_G02140
uniprot id: A0A8B8URN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WRB/GET1 family.
messages: Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.

27291:SPAR H00620
gene id: 27291:SPAR_H00620
uniprot id: A0A8B8USD0
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

27291:SPAR G03340
gene id: 27291:SPAR_G03340
uniprot id: A0A8B8URZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT6 family.
messages: Nucleus
messages: Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression.

27291:SPAR B01820
gene id: 27291:SPAR_B01820
uniprot id: A0A8B8ULK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

27291:SPAR B03190
gene id: 27291:SPAR_B03190
uniprot id: A0A8B8UM25
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

27291:SPAR D05090
gene id: 27291:SPAR_D05090
uniprot id: A0A8B8UP48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-O/MCM21 family.
messages: Nucleus

27291:SPAR B02240
gene id: 27291:SPAR_B02240
uniprot id: A0A8B8ULS8
names: Similarity
messages: Belongs to the PP2C family.

27291:SPAR B03080
gene id: 27291:SPAR_B03080
uniprot id: A0A8B8UMC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

27291:SPAR K02050
gene id: 27291:SPAR_K02050
uniprot id: A0A8B8UV34
names: Function
names: Similarity
messages: Belongs to the BYE1 family.
messages: Negative regulator of transcription elongation.

27291:SPAR L04330
gene id: 27291:SPAR_L04330
uniprot id: A0A8B8UWL3
names: Similarity
messages: Belongs to the WD repeat coronin family.

27291:SPAR P02040
gene id: 27291:SPAR_P02040
uniprot id: A0A8B8V155
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TIM50 family.
messages: Component of the TIM23 complex.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Mitochondrion inner membrane

27291:SPAR P04250
gene id: 27291:SPAR_P04250
uniprot id: A0A8B8V1N9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum
messages: Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.

27291:SPAR G03060
gene id: 27291:SPAR_G03060
uniprot id: A0A8B8URR0
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.

27291:SPAR P01070
gene id: 27291:SPAR_P01070
uniprot id: A0A8B8V0R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

27291:SPAR J00360
gene id: 27291:SPAR_J00360
uniprot id: A0A8B8UTT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP12 family.
messages: Mitochondrion

27291:SPAR D02380
gene id: 27291:SPAR_D02380
uniprot id: A0A8B8UNN9
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

27291:SPAR N03040
gene id: 27291:SPAR_N03040
uniprot id: A0A8B8UYU0
names: Similarity
messages: Belongs to the citrate synthase family.

27291:SPAR I00820
gene id: 27291:SPAR_I00820
uniprot id: A0A8B8UT60
names: Similarity
messages: Belongs to the glycosyltransferase 15 family.

27291:SPAR N02950
gene id: 27291:SPAR_N02950
uniprot id: A0A8B8UYT2
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

27291:SPAR G03890
gene id: 27291:SPAR_G03890
uniprot id: A0A8B8US52
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBP4 family.
messages: Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b.
messages: Mitochondrion inner membrane

27291:SPAR D00010
gene id: 27291:SPAR_D00010
uniprot id: A0A8B8UMP1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

27291:SPAR N03700
gene id: 27291:SPAR_N03700
uniprot id: A0A8B8UZ07
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR N03020
gene id: 27291:SPAR_N03020
uniprot id: A0A8B8UYT7
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

27291:SPAR B02750
gene id: 27291:SPAR_B02750
uniprot id: A0A8B8ULX9
names: Function
names: Similarity
messages: Belongs to the PanB family.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.

27291:SPAR E02380
gene id: 27291:SPAR_E02380
uniprot id: A0A8B8UQN1
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR D00590
gene id: 27291:SPAR_D00590
uniprot id: A0A8B8UMV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Endomembrane system
messages: Vacuole membrane

27291:SPAR D02760
gene id: 27291:SPAR_D02760
uniprot id: A0A8B8UNG4
names: Similarity
messages: Belongs to the CBF/MAK21 family.

27291:SPAR D05290
gene id: 27291:SPAR_D05290
uniprot id: A0A8B8UP64
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

27291:SPAR K02750
gene id: 27291:SPAR_K02750
uniprot id: A0A8B8UVA4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anamorsin family.
messages: Cytoplasm
messages: Mitochondrion intermembrane space
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

27291:SPAR G04170
gene id: 27291:SPAR_G04170
uniprot id: A0A8B8US22
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

27291:SPAR D01050
gene id: 27291:SPAR_D01050
uniprot id: A0A8B8UMZ5
names: Similarity
messages: Belongs to the cullin family.

27291:SPAR G02960
gene id: 27291:SPAR_G02960
uniprot id: A0A8B8URP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: Nucleus
messages: Required for pre-mRNA splicing.

27291:SPAR D05190
gene id: 27291:SPAR_D05190
uniprot id: A0A8B8UP54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YSP2 family.
messages: Membrane

27291:SPAR G01990
gene id: 27291:SPAR_G01990
uniprot id: A0A8B8URL3
names: Similarity
messages: Belongs to the isochorismatase family.

27291:SPAR D05420
gene id: 27291:SPAR_D05420
uniprot id: A0A8B8UP67
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR E00560
gene id: 27291:SPAR_E00560
uniprot id: A0A8B8UPV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EDC3 family.
messages: P-body

27291:SPAR B01460
gene id: 27291:SPAR_B01460
uniprot id: A0A8B8ULJ6
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR I01510
gene id: 27291:SPAR_I01510
uniprot id: A0A8B8UTK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR E01360
gene id: 27291:SPAR_E01360
uniprot id: A0A8B8UQ41
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.

27291:SPAR M00710
gene id: 27291:SPAR_M00710
uniprot id: A0A8B8UX12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the helicase family. PIF1 subfamily.
messages: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Involved in the maintenance of ribosomal (rDNA). Required for efficient fork arrest at the replicaion fork barrier within rDNA. Involved in the maintenance of mitochondrial (mtDNA). Required to maintain mtDNA under conditions that introduce dsDNA breaks in mtDNA, either preventing or repairing dsDNA breaks. May inhibit replication progression to allow time for repair. May have a general role in chromosomal replication by affecting Okazaki fragment maturation. May have a role in conjunction with DNA2 helicase/nuclease in 5'-flap extension during Okazaki fragment processing.
messages: Mitochondrion
messages: Monomer. Interacts with telomerase.
messages: Nucleus

27291:SPAR O03340
gene id: 27291:SPAR_O03340
uniprot id: A0A8B8V038
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

27291:SPAR M01880
gene id: 27291:SPAR_M01880
uniprot id: A0A8B8UX77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. NAA40 subfamily.
messages: Cytoplasm
messages: Nucleus

27291:SPAR G02990
gene id: 27291:SPAR_G02990
uniprot id: A0A8B8URW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit alpha family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

27291:SPAR H02170
gene id: 27291:SPAR_H02170
uniprot id: A0A8B8USX7
names: Similarity
messages: Belongs to the FMO family.

27291:SPAR E00340
gene id: 27291:SPAR_E00340
uniprot id: A0A8B8UPS9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space

27291:SPAR D01000
gene id: 27291:SPAR_D01000
uniprot id: A0A8B8UMY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR J03170
gene id: 27291:SPAR_J03170
uniprot id: A0A8B8UUE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HIR3 family.
messages: Nucleus

27291:SPAR I00430
gene id: 27291:SPAR_I00430
uniprot id: A0A8B8UT71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRT14 family.
messages: Involved in ribosome biogenesis, probably through modulation of rDNA transcription.
messages: nucleolus

27291:SPAR J02640
gene id: 27291:SPAR_J02640
uniprot id: A0A8B8UUA2
names: Similarity
messages: Belongs to the TMEM14 family.

27291:SPAR N01560
gene id: 27291:SPAR_N01560
uniprot id: A0A8B8UYE3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL42 family.

27291:SPAR M02020
gene id: 27291:SPAR_M02020
uniprot id: A0A8B8UX91
names: Function
messages: Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).

27291:SPAR N00550
gene id: 27291:SPAR_N00550
uniprot id: A0A8B8UY94
names: Similarity
messages: Belongs to the AB hydrolase superfamily. MetX family.

27291:SPAR F00300
gene id: 27291:SPAR_F00300
uniprot id: A0A8B8UQK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMCO4 family.
messages: Membrane

27291:SPAR G04020
gene id: 27291:SPAR_G04020
uniprot id: A0A8B8US04
names: Similarity
messages: Belongs to the glycosyl hydrolase 16 family.

27291:SPAR P02610
gene id: 27291:SPAR_P02610
uniprot id: A0A8B8V1A2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SNF8 family.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.
messages: Component of the endosomal sorting complex required for transport II (ESCRT-II).

27291:SPAR D03530
gene id: 27291:SPAR_D03530
uniprot id: A0A8B8UP09
names: Similarity
messages: Belongs to the peptidase A1 family.

27291:SPAR E01310
gene id: 27291:SPAR_E01310
uniprot id: A0A8B8UQ36
names: Similarity
messages: Belongs to the RutC family.

27291:SPAR N00080
gene id: 27291:SPAR_N00080
uniprot id: A0A8B8UXZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Nucleus

27291:SPAR D04660
gene id: 27291:SPAR_D04660
uniprot id: A0A8B8UP08
names: Function
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

27291:SPAR N02070
gene id: 27291:SPAR_N02070
uniprot id: A0A8B8UYJ7
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.

27291:SPAR K01050
gene id: 27291:SPAR_K01050
uniprot id: A0A8B8UUT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLD2 family.
messages: Has a role in the initiation of DNA replication. Required at S-phase checkpoint.
messages: Nucleus

27291:SPAR B02180
gene id: 27291:SPAR_B02180
uniprot id: A0A8B8UM39
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

27291:SPAR P03780
gene id: 27291:SPAR_P03780
uniprot id: A0A8B8V1I2
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR P02250
gene id: 27291:SPAR_P02250
uniprot id: A0A8B8V139
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

27291:SPAR J00600
gene id: 27291:SPAR_J00600
uniprot id: A0A8B8UTN4
names: Function
names: Similarity
messages: Belongs to the VPS35 family.
messages: Plays a role in vesicular protein sorting.

27291:SPAR N02390
gene id: 27291:SPAR_N02390
uniprot id: A0A8B8UYM4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

27291:SPAR O00790
gene id: 27291:SPAR_O00790
uniprot id: A0A8B8UZD6
names: Subcellular Location Annotation
messages: Membrane

27291:A560 mgp07
gene id: 27291:A560_mgp07
uniprot id: Q71U89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase protein 8 family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

27291:SPAR H00740
gene id: 27291:SPAR_H00740
uniprot id: A0A8B8USF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Membrane

27291:SPAR H00430
gene id: 27291:SPAR_H00430
uniprot id: A0A8B8USK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR B02610
gene id: 27291:SPAR_B02610
uniprot id: A0A8B8ULV6
names: Similarity
messages: Belongs to the PGA52 family.

27291:SPAR P02600
gene id: 27291:SPAR_P02600
uniprot id: A0A8B8V176
names: Function
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
messages: Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.

27291:SPAR J02330
gene id: 27291:SPAR_J02330
uniprot id: A0A8B8UUB3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Binds 1 FAD per monomer.
messages: Irreversibly catalyzes the reduction of fumarate to succinate.

27291:SPAR E01220
gene id: 27291:SPAR_E01220
uniprot id: A0A8B8UQ08
names: Similarity
messages: Belongs to the TPA1 family.

27291:SPAR O00740
gene id: 27291:SPAR_O00740
uniprot id: A0A8B8UZD0
names: Similarity
messages: Belongs to the SIN1 family.

27291:SPAR G00340
gene id: 27291:SPAR_G00340
uniprot id: A0A8B8UR52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST5 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

27291:SPAR B03930
gene id: 27291:SPAR_B03930
uniprot id: A0A8B8UML1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

27291:SPAR P02080
gene id: 27291:SPAR_P02080
uniprot id: A0A8B8V114
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR B03780
gene id: 27291:SPAR_B03780
uniprot id: A0A8B8UMJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Membrane

27291:SPAR B00160
gene id: 27291:SPAR_B00160
uniprot id: A0A8B8UL54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND2 (condensin subunit 2) family.
messages: Chromosome
messages: Cytoplasm
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.

27291:SPAR I01160
gene id: 27291:SPAR_I01160
uniprot id: A0A8B8UTH1
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

27291:SPAR O01380
gene id: 27291:SPAR_O01380
uniprot id: A0A8B8UZF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: nucleolus

27291:SPAR L02990
gene id: 27291:SPAR_L02990
uniprot id: A0A8B8UWC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: cytosol

27291:SPAR B03240
gene id: 27291:SPAR_B03240
uniprot id: A0A8B8UM31
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

27291:SPAR K02700
gene id: 27291:SPAR_K02700
uniprot id: A0A8B8UV99
names: Function
names: Similarity
messages: Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

27291:SPAR H00340
gene id: 27291:SPAR_H00340
uniprot id: A0A8B8USB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

27291:SPAR L00940
gene id: 27291:SPAR_L00940
uniprot id: A0A8B8UVM3
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

27291:SPAR I01000
gene id: 27291:SPAR_I01000
uniprot id: A0A8B8UT77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.

27291:SPAR L02040
gene id: 27291:SPAR_L02040
uniprot id: A0A8B8UW31
names: Similarity
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.
messages: In the N-terminal section; belongs to the ubiquitin family.

27291:SPAR B03900
gene id: 27291:SPAR_B03900
uniprot id: A0A8B8UM94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter.

27291:SPAR M00540
gene id: 27291:SPAR_M00540
uniprot id: A0A8B8UX08
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

27291:SPAR G03250
gene id: 27291:SPAR_G03250
uniprot id: A0A8B8URP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

27291:SPAR L02420
gene id: 27291:SPAR_L02420
uniprot id: A0A8B8UW84
names: Similarity
messages: Belongs to the cyclin family.

27291:SPAR J00930
gene id: 27291:SPAR_J00930
uniprot id: A0A8B8UTW4
names: Similarity
messages: Belongs to the SUN family.

27291:SPAR G03470
gene id: 27291:SPAR_G03470
uniprot id: A0A8B8URV0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SYF2 family.
messages: Involved in pre-mRNA splicing.
messages: May be part of a spliceosome complex.
messages: Nucleus

27291:SPAR M01590
gene id: 27291:SPAR_M01590
uniprot id: A0A8B8UXB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family. IMP2 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR N03730
gene id: 27291:SPAR_N03730
uniprot id: A0A8B8UZ56
names: Similarity
messages: Belongs to the mannitol dehydrogenase family.

27291:SPAR L03870
gene id: 27291:SPAR_L03870
uniprot id: A0A8B8UWM8
names: Similarity
messages: Belongs to the FBPase class 1 family.

27291:SPAR K01500
gene id: 27291:SPAR_K01500
uniprot id: A0A8B8UUX5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BLI1 family.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) composed of at least BLI1, BLS1, CNL1, KXD1, SNN1 and VAB2.
messages: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.

27291:SPAR F00850
gene id: 27291:SPAR_F00850
uniprot id: A0A8B8UQR6
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

27291:SPAR B00790
gene id: 27291:SPAR_B00790
uniprot id: A0A8B8ULC9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL19 family.

27291:SPAR E02470
gene id: 27291:SPAR_E02470
uniprot id: A0A8B8UQD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad17/RAD24 family.
messages: Nucleus

27291:SPAR K01990
gene id: 27291:SPAR_K01990
uniprot id: A0A8B8UV16
names: Similarity
messages: Belongs to the UPL family. K-HECT subfamily.

27291:SPAR H01830
gene id: 27291:SPAR_H01830
uniprot id: A0A8B8USP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CHS7 family.
messages: Chaperone required for the export of the chitin synthase CHS3 from the endoplasmic reticulum.
messages: Interacts with CHS3.
messages: Membrane

27291:SPAR O01120
gene id: 27291:SPAR_O01120
uniprot id: A0A8B8UZH4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.

27291:SPAR F00320
gene id: 27291:SPAR_F00320
uniprot id: A0A8B8UQT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family.
messages: Nucleus

27291:SPAR D02480
gene id: 27291:SPAR_D02480
uniprot id: A0A8B8UNQ0
names: Similarity
messages: Belongs to the VPS54 family.

27291:SPAR C00090
gene id: 27291:SPAR_C00090
uniprot id: A0A8B8UMM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRR1 family.
messages: Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.
messages: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.
messages: nucleolus

27291:SPAR O00840
gene id: 27291:SPAR_O00840
uniprot id: A0A8B8UZE1
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.

27291:SPAR N00660
gene id: 27291:SPAR_N00660
uniprot id: A0A8B8UY57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIF1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Has a role in transport between endoplasmic reticulum and Golgi.
messages: Membrane

27291:SPAR L02460
gene id: 27291:SPAR_L02460
uniprot id: A0A8B8UW24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferric reductase (FRE) family.
messages: Membrane

27291:SPAR O02000
gene id: 27291:SPAR_O02000
uniprot id: A0A8B8UZK9
names: Similarity
messages: Belongs to the protein kinase superfamily.

27291:SPAR D00800
gene id: 27291:SPAR_D00800
uniprot id: A0A8B8UMX0
names: Similarity
messages: Belongs to the CENP-X/MHF2 family.

27291:SPAR M03740
gene id: 27291:SPAR_M03740
uniprot id: A0A8B8UXX3
names: Similarity
messages: Belongs to the THADA family.

27291:SPAR D04900
gene id: 27291:SPAR_D04900
uniprot id: A0A8B8UP34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AATF family.
messages: nucleolus

27291:SPAR P01590
gene id: 27291:SPAR_P01590
uniprot id: A0A8B8V109
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

27291:SPAR K00100
gene id: 27291:SPAR_K00100
uniprot id: A0A8B8UUI6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with mRNPs. Interacts with YRA1.
messages: Belongs to the YRA1 family.
messages: Involved in export of poly(A) mRNAs from the nucleus. Recruited to the coding sequences as well as poly-A sites of active genes.
messages: Nucleus

27291:SPAR J01390
gene id: 27291:SPAR_J01390
uniprot id: A0A8B8UTY6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COA3 family.
messages: Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes composed at least COA3, COX14, COX5A, SHY1 and SSC1. Interacts with COX1 and MSS51.
messages: Membrane
messages: Required for assembly of cytochrome c oxidase (complex IV). With COX14, regulates negatively COX1 translation and is involved in MSS51 association with newly synthesized COX1.

27291:SPAR M04300
gene id: 27291:SPAR_M04300
uniprot id: A0A8B8UXX9
names: Function
names: Similarity
messages: Belongs to the peptidase T1A family.
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

27291:SPAR E01500
gene id: 27291:SPAR_E01500
uniprot id: A0A8B8UQ60
names: Similarity
messages: Belongs to the YOS1 family.

27291:SPAR L02630
gene id: 27291:SPAR_L02630
uniprot id: A0A8B8UW43
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

27291:SPAR G00500
gene id: 27291:SPAR_G00500
uniprot id: A0A8B8UQW9
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.

27291:SPAR O01010
gene id: 27291:SPAR_O01010
uniprot id: A0A8B8UZB7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Binds 1 pyruvoyl group covalently per subunit.

27291:SPAR D00620
gene id: 27291:SPAR_D00620
uniprot id: A0A8B8UMT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase inhibitor family.
messages: Inhibits the enzyme activity of ATPase.
messages: Mitochondrion

27291:SPAR A00130
gene id: 27291:SPAR_A00130
uniprot id: A0A8B8ULA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor potential (TRP) ion channel family.
messages: Membrane

27291:SPAR A00640
gene id: 27291:SPAR_A00640
uniprot id: A0A8B8UL10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

27291:SPAR N01730
gene id: 27291:SPAR_N01730
uniprot id: A0A8B8UYF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

27291:SPAR B01340
gene id: 27291:SPAR_B01340
uniprot id: A0A8B8ULI4
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

27291:SPAR P00870
gene id: 27291:SPAR_P00870
uniprot id: A0A8B8V0P1
names: Similarity
messages: Belongs to the NAD kinase family.

27291:SPAR D07090
gene id: 27291:SPAR_D07090
uniprot id: A0A8B8UQ00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for the ferulic acid decarboxylase FDC1. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Mitochondrion
messages: Oligomer.

27291:SPAR B01320
gene id: 27291:SPAR_B01320
uniprot id: A0A8B8ULE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

27291:SPAR D02530
gene id: 27291:SPAR_D02530
uniprot id: A0A8B8UNQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal/bacterial/fungal opsin family.
messages: Membrane

27291:SPAR O04370
gene id: 27291:SPAR_O04370
uniprot id: A0A8B8V0F2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-A family.
messages: Involved in the replication of mitochondrial DNA.
messages: Mitochondrion

27291:SPAR O01370
gene id: 27291:SPAR_O01370
uniprot id: A0A8B8UZK0
names: Similarity
messages: Belongs to the lysophospholipase family.

27291:SPAR O00180
gene id: 27291:SPAR_O00180
uniprot id: A0A8B8UZ31
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
messages: Mitochondrion matrix

27291:SPAR D03690
gene id: 27291:SPAR_D03690
uniprot id: A0A8B8UNR2
names: Function
names: Similarity
messages: Belongs to the CWC15 family.
messages: Involved in pre-mRNA splicing.

27291:SPAR L03740
gene id: 27291:SPAR_L03740
uniprot id: A0A8B8UWJ3
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

27291:SPAR P01740
gene id: 27291:SPAR_P01740
uniprot id: A0A8B8V124
names: Similarity
messages: Belongs to the transglutaminase-like superfamily. PNGase family.

27291:SPAR D06140
gene id: 27291:SPAR_D06140
uniprot id: A0A8B8UPQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit G family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.

27291:SPAR E01350
gene id: 27291:SPAR_E01350
uniprot id: A0A8B8UQ45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

27291:SPAR G00660
gene id: 27291:SPAR_G00660
uniprot id: A0A8B8UR22
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

27291:SPAR D03740
gene id: 27291:SPAR_D03740
uniprot id: A0A8B8UNR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

27291:SPAR G04970
gene id: 27291:SPAR_G04970
uniprot id: A0A8B8US97
names: Similarity
messages: Belongs to the MAL13 family.

27291:SPAR H01350
gene id: 27291:SPAR_H01350
uniprot id: A0A8B8USQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR D02320
gene id: 27291:SPAR_D02320
uniprot id: A0A8B8UNA5
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR P00580
gene id: 27291:SPAR_P00580
uniprot id: A0A8B8V0L0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. SAR1 family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

27291:SPAR D04530
gene id: 27291:SPAR_D04530
uniprot id: A0A8B8UPA5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42.

27291:SPAR O01600
gene id: 27291:SPAR_O01600
uniprot id: A0A8B8UZH0
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

27291:SPAR L02028
gene id: 27291:SPAR_L02028
uniprot id: A0A8B8UVX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CybS family.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR H02150
gene id: 27291:SPAR_H02150
uniprot id: A0A8B8USV3
names: Similarity
messages: Belongs to the enolase family.

27291:SPAR H01730
gene id: 27291:SPAR_H01730
uniprot id: A0A8B8USX1
names: Function
names: Similarity
messages: Belongs to the endosulfine family.
messages: Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.

27291:SPAR N02620
gene id: 27291:SPAR_N02620
uniprot id: A0A8B8UYQ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA(4) but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B(4) as the product compared to the homologous mammalian enzyme (in vitro).
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

27291:SPAR M02980
gene id: 27291:SPAR_M02980
uniprot id: A0A8B8UXI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

27291:SPAR J00270
gene id: 27291:SPAR_J00270
uniprot id: A0A8B8UTL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SOP4 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the export of PMA1, possibly through the monitoring or assisting of PMA1 folding and acquisition of competence to enter vesicles.
messages: Membrane

27291:SPAR F01110
gene id: 27291:SPAR_F01110
uniprot id: A0A8B8UQP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1B family.
messages: Cytoplasm
messages: Non-catalytic component of the proteasome.
messages: Nucleus

27291:SPAR I01910
gene id: 27291:SPAR_I01910
uniprot id: A0A8B8UTP2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

27291:SPAR P00370
gene id: 27291:SPAR_P00370
uniprot id: A0A8B8V0J2
names: Similarity
messages: Belongs to the heat shock protein 90 family.

27291:SPAR B02350
gene id: 27291:SPAR_B02350
uniprot id: A0A8B8ULU0
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.

27291:SPAR D03660
gene id: 27291:SPAR_D03660
uniprot id: A0A8B8UNQ4
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR M02840
gene id: 27291:SPAR_M02840
uniprot id: A0A8B8UXN4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

27291:SPAR F00030
gene id: 27291:SPAR_F00030
uniprot id: A0A8B8UMP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NMT1/THI5 family.
messages: Homodimer.
messages: Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.

27291:SPAR D06190
gene id: 27291:SPAR_D06190
uniprot id: A0A8B8UPR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-Z subfamily.
messages: Cytoplasm

27291:SPAR K00810
gene id: 27291:SPAR_K00810
uniprot id: A0A8B8UUV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion inner membrane
messages: Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.

27291:SPAR M04400
gene id: 27291:SPAR_M04400
uniprot id: A0A8B8UXY9
names: Similarity
messages: Belongs to the mannitol dehydrogenase family.

27291:SPAR A00390
gene id: 27291:SPAR_A00390
uniprot id: A0A8B8UKY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

27291:SPAR J01500
gene id: 27291:SPAR_J01500
uniprot id: A0A8B8UTY7
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

27291:SPAR D02750
gene id: 27291:SPAR_D02750
uniprot id: A0A8B8UNG8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

27291:SPAR O03350
gene id: 27291:SPAR_O03350
uniprot id: A0A8B8V004
names: Similarity
messages: Belongs to the WD repeat G protein beta family.

27291:SPAR O00090
gene id: 27291:SPAR_O00090
uniprot id: A0A8B8UZ66
names: Similarity
messages: Belongs to the DCP1 family.

27291:SPAR B00470
gene id: 27291:SPAR_B00470
uniprot id: A0A8B8UL42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion inner membrane
messages: Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.

27291:SPAR E02210
gene id: 27291:SPAR_E02210
uniprot id: A0A8B8UQC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

27291:SPAR D02660
gene id: 27291:SPAR_D02660
uniprot id: A0A8B8UNF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKZF1/VMS1 family.
messages: Cytoplasm

27291:SPAR B01510
gene id: 27291:SPAR_B01510
uniprot id: A0A8B8UND6
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

27291:SPAR K00240
gene id: 27291:SPAR_K00240
uniprot id: A0A8B8UUJ3
names: Subcellular Location Annotation
messages: cytosol

27291:SPAR N01090
gene id: 27291:SPAR_N01090
uniprot id: A0A8B8UYA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAP1 family.
messages: Homodimer.
messages: Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE).
messages: Nucleus
messages: telomere

27291:SPAR G02490
gene id: 27291:SPAR_G02490
uniprot id: A0A8B8URR8
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

27291:SPAR O01950
gene id: 27291:SPAR_O01950
uniprot id: A0A8B8UZK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOB1 family.
messages: Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm.
messages: nucleolus

27291:SPAR M03190
gene id: 27291:SPAR_M03190
uniprot id: A0A8B8UXR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

27291:SPAR P01190
gene id: 27291:SPAR_P01190
uniprot id: A0A8B8V0X1
names: Similarity
messages: Belongs to the peptidase A1 family.

27291:SPAR H00350
gene id: 27291:SPAR_H00350
uniprot id: A0A8B8USE4
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

27291:SPAR D02570
gene id: 27291:SPAR_D02570
uniprot id: A0A8B8UND0
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

27291:SPAR N00160
gene id: 27291:SPAR_N00160
uniprot id: A0A8B8UY08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Membrane

27291:SPAR I00880
gene id: 27291:SPAR_I00880
uniprot id: A0A8B8UTB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COPE family.
messages: Cytoplasm
messages: Membrane
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

27291:SPAR O03100
gene id: 27291:SPAR_O03100
uniprot id: A0A8B8UZX4
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.

27291:SPAR B00230
gene id: 27291:SPAR_B00230
uniprot id: A0A8B8ULJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Vacuole membrane

27291:SPAR N03400
gene id: 27291:SPAR_N03400
uniprot id: A0A8B8UYY0
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.

27291:SPAR H02280
gene id: 27291:SPAR_H02280
uniprot id: A0A8B8UST9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP5 family.
messages: Cytoplasm
messages: Nucleus

27291:SPAR G01470
gene id: 27291:SPAR_G01470
uniprot id: A0A8B8UR97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the USE1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR F00630
gene id: 27291:SPAR_F00630
uniprot id: A0A8B8UQL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YPI1 family.
messages: Nucleus
messages: Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.

27291:SPAR N01490
gene id: 27291:SPAR_N01490
uniprot id: A0A8B8UYD8
names: Similarity
messages: Belongs to the FAH family.

27291:SPAR P01500
gene id: 27291:SPAR_P01500
uniprot id: A0A8B8V0W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFR1/MEI5 family.
messages: Nucleus

27291:SPAR M02480
gene id: 27291:SPAR_M02480
uniprot id: A0A8B8UXD9
names: Similarity
messages: Belongs to the CCDC25 family.

27291:SPAR K02530
gene id: 27291:SPAR_K02530
uniprot id: A0A8B8UVC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMP46 family.
messages: Mitochondrion
messages: Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.

27291:SPAR D05450
gene id: 27291:SPAR_D05450
uniprot id: A0A8B8UP93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPC110 family.
messages: Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication. Potential role in cross-linking filaments or anchoring other molecules. It is essential for growth.
messages: Nucleus
messages: spindle pole body

27291:SPAR J01550
gene id: 27291:SPAR_J01550
uniprot id: A0A8B8UTZ1
names: Similarity
messages: Belongs to the cullin family.

27291:SPAR C00690
gene id: 27291:SPAR_C00690
uniprot id: A0A8B8UMS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus

27291:SPAR K03010
gene id: 27291:SPAR_K03010
uniprot id: A0A8B8UVH7
names: Similarity
messages: Belongs to the peptidase C19 family.

27291:SPAR I00680
gene id: 27291:SPAR_I00680
uniprot id: A0A8B8UT98
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.

27291:SPAR D05520
gene id: 27291:SPAR_D05520
uniprot id: A0A8B8UP77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DSS1/SEM1 family.
messages: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Nucleus

27291:SPAR K00800
gene id: 27291:SPAR_K00800
uniprot id: A0A8B8UUQ6
names: Subcellular Location Annotation
names: Subunit
messages: Component of the mitochondrial large ribosomal subunit.
messages: Mitochondrion

27291:SPAR H01040
gene id: 27291:SPAR_H01040
uniprot id: A0A8B8USI4
names: Similarity
messages: Belongs to the ketopantoate reductase family.

27291:SPAR D06460
gene id: 27291:SPAR_D06460
uniprot id: A0A8B8UPJ5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.

27291:SPAR D00840
gene id: 27291:SPAR_D00840
uniprot id: A0A8B8UMY0
names: Function
names: Similarity
messages: Belongs to the WD repeat DDB2/WDR76 family.
messages: DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes.

27291:SPAR L02660
gene id: 27291:SPAR_L02660
uniprot id: A0A8B8UW45
names: Function
names: Similarity
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.

27291:SPAR L03200
gene id: 27291:SPAR_L03200
uniprot id: A0A8B8UW99
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HRI1 family.
messages: Cytoplasm
messages: Interacts with HRR25. May interact with SEC72.
messages: Nucleus

27291:SPAR B01420
gene id: 27291:SPAR_B01420
uniprot id: A0A8B8ULF5
names: Similarity
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.

27291:SPAR O02340
gene id: 27291:SPAR_O02340
uniprot id: A0A8B8UZT6
names: Similarity
messages: Belongs to the glycosyltransferase 15 family.

27291:SPAR J01350
gene id: 27291:SPAR_J01350
uniprot id: A0A8B8UTX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the esterase D family.
messages: Cytoplasm
messages: Serine hydrolase involved in the detoxification of formaldehyde.

27291:SPAR L03950
gene id: 27291:SPAR_L03950
uniprot id: A0A8B8UWH6
names: Similarity
messages: Belongs to the VAC14 family.

27291:SPAR P02800
gene id: 27291:SPAR_P02800
uniprot id: A0A8B8V196
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

27291:SPAR H00770
gene id: 27291:SPAR_H00770
uniprot id: A0A8B8USE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

27291:SPAR B02530
gene id: 27291:SPAR_B02530
uniprot id: A0A8B8UM71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Nucleus

27291:SPAR D02310
gene id: 27291:SPAR_D02310
uniprot id: A0A8B8UNC1
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

27291:SPAR L03450
gene id: 27291:SPAR_L03450
uniprot id: A0A8B8UWC4
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

27291:SPAR J00510
gene id: 27291:SPAR_J00510
uniprot id: A0A8B8UTU3
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR J02910
gene id: 27291:SPAR_J02910
uniprot id: A0A8B8UUI3
names: Subcellular Location Annotation
messages: Nucleus
messages: kinetochore

27291:SPAR O03090
gene id: 27291:SPAR_O03090
uniprot id: A0A8B8V010
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS30 family.

27291:SPAR E00600
gene id: 27291:SPAR_E00600
uniprot id: A0A8B8UPX3
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR M02330
gene id: 27291:SPAR_M02330
uniprot id: A0A8B8UXC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC24 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

27291:SPAR H01270
gene id: 27291:SPAR_H01270
uniprot id: A0A8B8USJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STE12 transcription factor family.
messages: Nucleus

27291:SPAR N02920
gene id: 27291:SPAR_N02920
uniprot id: A0A8B8UYS8
names: Similarity
messages: Belongs to the lysophospholipase family.

27291:SPAR N02160
gene id: 27291:SPAR_N02160
uniprot id: A0A8B8UYQ8
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR B02280
gene id: 27291:SPAR_B02280
uniprot id: A0A8B8UM49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG14 family.
messages: Membrane
messages: Vacuole membrane

27291:SPAR C00590
gene id: 27291:SPAR_C00590
uniprot id: A0A8B8UMR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290). In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.
messages: Cytoplasm

27291:SPAR O02860
gene id: 27291:SPAR_O02860
uniprot id: A0A8B8UZV1
names: Subunit
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

27291:SPAR J02050
gene id: 27291:SPAR_J02050
uniprot id: A0A8B8UU51
names: Domain
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DENR family.
messages: Cytoplasm
messages: Interacts with the 40S ribosomal subunit.
messages: The SUI1 domain may be involved in RNA binding.

27291:SPAR G02530
gene id: 27291:SPAR_G02530
uniprot id: A0A8B8URG4
names: Cofactor
names: Function
names: Similarity
messages: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
messages: Belongs to the tRNA(His) guanylyltransferase family.
messages: Binds 2 magnesium ions per subunit.

27291:SPAR G04760
gene id: 27291:SPAR_G04760
uniprot id: A0A8B8US80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Nucleus

27291:SPAR M01400
gene id: 27291:SPAR_M01400
uniprot id: A0A8B8UX34
names: Similarity
messages: Belongs to the EFG1/PHD1/stuA family.

27291:SPAR N00830
gene id: 27291:SPAR_N00830
uniprot id: A0A8B8UY68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CWC25 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

27291:SPAR P03130
gene id: 27291:SPAR_P03130
uniprot id: A0A8B8V1B7
names: Function
names: Similarity
messages: Belongs to the SEC8 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

27291:SPAR K00180
gene id: 27291:SPAR_K00180
uniprot id: A0A8B8UUP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PSMG2 family.
messages: Component of the 20S proteasome chaperone.
messages: Involved in 20S proteasome assembly.

27291:SPAR D03390
gene id: 27291:SPAR_D03390
uniprot id: A0A8B8UNN2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: In the 2nd section; belongs to the EPSP synthase family.
messages: In the 2nd section; belongs to the type-I 3-dehydroquinase family.
messages: In the 3rd section; belongs to the shikimate kinase family.
messages: In the 4th section; belongs to the type-I 3-dehydroquinase family.
messages: In the C-terminal section; belongs to the shikimate dehydrogenase family.
messages: In the N-terminal section; belongs to the dehydroquinate synthase family.
messages: In the N-terminal section; belongs to the shikimate kinase family.
messages: In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.

27291:SPAR B00140
gene id: 27291:SPAR_B00140
uniprot id: A0A8B8UL53
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

27291:SPAR P02120
gene id: 27291:SPAR_P02120
uniprot id: A0A8B8V117
names: Similarity
messages: Belongs to the glycosyltransferase 15 family.

27291:SPAR H01850
gene id: 27291:SPAR_H01850
uniprot id: A0A8B8USS3
names: Similarity
messages: Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.

27291:SPAR A00080
gene id: 27291:SPAR_A00080
uniprot id: A0A8B8ULA4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

27291:SPAR D05360
gene id: 27291:SPAR_D05360
uniprot id: A0A8B8UP75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVF1 family.
messages: Cytoplasm

27291:SPAR J03140
gene id: 27291:SPAR_J03140
uniprot id: A0A8B8UUF0
names: Similarity
messages: Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

27291:SPAR B03950
gene id: 27291:SPAR_B03950
uniprot id: A0A8B8UM99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

27291:SPAR O00020
gene id: 27291:SPAR_O00020
uniprot id: A0A8B8UTH9
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR B01720
gene id: 27291:SPAR_B01720
uniprot id: A0A8B8ULI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

27291:SPAR K00210
gene id: 27291:SPAR_K00210
uniprot id: A0A8B8UUP1
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.

27291:SPAR L01450
gene id: 27291:SPAR_L01450
uniprot id: A0A8B8UVY3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

27291:SPAR M03050
gene id: 27291:SPAR_M03050
uniprot id: A0A8B8UXK4
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

27291:SPAR N00920
gene id: 27291:SPAR_N00920
uniprot id: A0A8B8UYC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 16 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

27291:SPAR G03150
gene id: 27291:SPAR_G03150
uniprot id: A0A8B8URM8
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

27291:SPAR O01810
gene id: 27291:SPAR_O01810
uniprot id: A0A8B8UZJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat HIR1 family.
messages: Nucleus
messages: Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

27291:SPAR K03050
gene id: 27291:SPAR_K03050
uniprot id: A0A8B8UVD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flocculin family.
messages: Membrane

27291:SPAR K01660
gene id: 27291:SPAR_K01660
uniprot id: A0A8B8UV42
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.

27291:SPAR D03650
gene id: 27291:SPAR_D03650
uniprot id: A0A8B8UNQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAC3 family.
messages: Nucleus envelope

27291:SPAR I01410
gene id: 27291:SPAR_I01410
uniprot id: A0A8B8UTJ4
names: Similarity
messages: Belongs to the peptidase A1 family.

27291:SPAR D06350
gene id: 27291:SPAR_D06350
uniprot id: A0A8B8UPH1
names: Similarity
messages: Belongs to the guanylate kinase family.

27291:SPAR N00360
gene id: 27291:SPAR_N00360
uniprot id: A0A8B8UY27
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

27291:SPAR D05890
gene id: 27291:SPAR_D05890
uniprot id: A0A8B8UPC4
names: Similarity
messages: Belongs to the IUNH family.

27291:SPAR D01010
gene id: 27291:SPAR_D01010
uniprot id: A0A8B8UMZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

27291:SPAR N03150
gene id: 27291:SPAR_N03150
uniprot id: A0A8B8UYV5
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR E02350
gene id: 27291:SPAR_E02350
uniprot id: A0A8B8UQG6
names: Similarity
messages: Belongs to the SPT2 family.

27291:SPAR D05210
gene id: 27291:SPAR_D05210
uniprot id: A0A8B8UP60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-3 family.
messages: Membrane
messages: Peroxisome membrane

27291:SPAR J03290
gene id: 27291:SPAR_J03290
uniprot id: A0A8B8UUG7
names: Similarity
messages: Belongs to the glycosyl hydrolase 28 family.

27291:SPAR P00670
gene id: 27291:SPAR_P00670
uniprot id: A0A8B8V0M3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: kinetochore
messages: spindle

27291:SPAR P03660
gene id: 27291:SPAR_P03660
uniprot id: A0A8B8V1L2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus

27291:SPAR F00610
gene id: 27291:SPAR_F00610
uniprot id: A0A8B8UQK0
names: Similarity
messages: Belongs to the LOC1 family.

27291:SPAR D01180
gene id: 27291:SPAR_D01180
uniprot id: A0A8B8UNB9
names: Similarity
messages: Belongs to the frataxin family.

27291:SPAR O02840
gene id: 27291:SPAR_O02840
uniprot id: A0A8B8UZY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ISN1 family.
messages: Homotetramer.
messages: IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation.

27291:SPAR L03230
gene id: 27291:SPAR_L03230
uniprot id: A0A8B8UWA4
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

27291:SPAR E01420
gene id: 27291:SPAR_E01420
uniprot id: A0A8B8UQ29
names: Function
names: Similarity
messages: Belongs to the RGI1 family.
messages: Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions.

27291:SPAR M00890
gene id: 27291:SPAR_M00890
uniprot id: A0A8B8UX41
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

27291:SPAR O00560
gene id: 27291:SPAR_O00560
uniprot id: A0A8B8UZ69
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

27291:SPAR M02660
gene id: 27291:SPAR_M02660
uniprot id: A0A8B8UXK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Mitochondrion inner membrane

27291:SPAR K02430
gene id: 27291:SPAR_K02430
uniprot id: A0A8B8UVB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex SPC34 family.
messages: Nucleus
messages: kinetochore
messages: spindle

27291:SPAR J02400
gene id: 27291:SPAR_J02400
uniprot id: A0A8B8UU84
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

27291:SPAR D03220
gene id: 27291:SPAR_D03220
uniprot id: A0A8B8UNJ6
names: Similarity
messages: Belongs to the FGGY kinase family.

27291:SPAR P03290
gene id: 27291:SPAR_P03290
uniprot id: A0A8B8V1I1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

27291:SPAR L03800
gene id: 27291:SPAR_L03800
uniprot id: A0A8B8UWG2
names: Similarity
messages: Belongs to the heat shock protein 70 family.

27291:SPAR E00210
gene id: 27291:SPAR_E00210
uniprot id: A0A8B8UPS3
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

27291:SPAR E02230
gene id: 27291:SPAR_E02230
uniprot id: A0A8B8UQL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBP family.
messages: Nucleus

27291:SPAR G00690
gene id: 27291:SPAR_G00690
uniprot id: A0A8B8UR87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

27291:SPAR P00270
gene id: 27291:SPAR_P00270
uniprot id: A0A8B8V0I1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

27291:SPAR O04640
gene id: 27291:SPAR_O04640
uniprot id: A0A8B8V0H0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit B family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

27291:SPAR J02890
gene id: 27291:SPAR_J02890
uniprot id: A0A8B8UUC4
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

27291:SPAR O04870
gene id: 27291:SPAR_O04870
uniprot id: A0A8B8V0J8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.
messages: Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

27291:SPAR C01020
gene id: 27291:SPAR_C01020
uniprot id: A0A8B8UMJ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Sterol O-acyltransferase that catalyzes the formation of stery esters.

27291:SPAR E00390
gene id: 27291:SPAR_E00390
uniprot id: A0A8B8UPT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

27291:SPAR O04100
gene id: 27291:SPAR_O04100
uniprot id: A0A8B8V073
names: Similarity
messages: Belongs to the MBF1 family.

27291:SPAR L03330
gene id: 27291:SPAR_L03330
uniprot id: A0A8B8UWB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck

27291:SPAR M01230
gene id: 27291:SPAR_M01230
uniprot id: A0A8B8UX14
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

27291:SPAR O04490
gene id: 27291:SPAR_O04490
uniprot id: A0A8B8V0F4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-Y family.
messages: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
messages: Nucleus

27291:SPAR M01290
gene id: 27291:SPAR_M01290
uniprot id: A0A8B8UX80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane
messages: Required for vacuolar protein sorting.

27291:SPAR D02580
gene id: 27291:SPAR_D02580
uniprot id: A0A8B8UNR3
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.

27291:SPAR K02550
gene id: 27291:SPAR_K02550
uniprot id: A0A8B8UV83
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR G03260
gene id: 27291:SPAR_G03260
uniprot id: A0A8B8URS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VMA21 family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Functions with VOA1 in assembly of the integral membrane sector (also called V0 sector) of the V-ATPase in the endoplasmic reticulum. Escorts the assembled V0 sector in COPII vesicles. Also required for normal packaging of the SNARE BOS1 and possibly the ER to Golgi transport receptor ERV29.

27291:SPAR L04360
gene id: 27291:SPAR_L04360
uniprot id: A0A8B8UWL7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

27291:SPAR J03300
gene id: 27291:SPAR_J03300
uniprot id: A0A8B8UUH1
names: Similarity
messages: Belongs to the PhyH family.

27291:SPAR G04070
gene id: 27291:SPAR_G04070
uniprot id: A0A8B8US11
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.

27291:SPAR P04290
gene id: 27291:SPAR_P04290
uniprot id: A0A8B8V1X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.
messages: Nucleus

27291:SPAR N01060
gene id: 27291:SPAR_N01060
uniprot id: A0A8B8UY97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR O00210
gene id: 27291:SPAR_O00210
uniprot id: A0A8B8UZ33
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR H02310
gene id: 27291:SPAR_H02310
uniprot id: A0A8B8UT01
names: Function
names: Similarity
messages: Belongs to the phytoene/squalene synthase family.
messages: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.

27291:SPAR D04870
gene id: 27291:SPAR_D04870
uniprot id: A0A8B8UP10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL67 family.
messages: Mitochondrion

27291:SPAR M02770
gene id: 27291:SPAR_M02770
uniprot id: A0A8B8UXG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

27291:SPAR N00900
gene id: 27291:SPAR_N00900
uniprot id: A0A8B8UYD2
names: Similarity
messages: Belongs to the peptidase S8 family. Furin subfamily.

27291:SPAR H00370
gene id: 27291:SPAR_H00370
uniprot id: A0A8B8USA0
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

27291:SPAR N02220
gene id: 27291:SPAR_N02220
uniprot id: A0A8B8UYL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase family.
messages: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
messages: Homodimer.

27291:SPAR G03040
gene id: 27291:SPAR_G03040
uniprot id: A0A8B8URX1
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.

27291:SPAR B01840
gene id: 27291:SPAR_B01840
uniprot id: A0A8B8ULN8
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

27291:SPAR P02150
gene id: 27291:SPAR_P02150
uniprot id: A0A8B8V128
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

27291:SPAR B01030
gene id: 27291:SPAR_B01030
uniprot id: A0A8B8ULS9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

27291:SPAR I01930
gene id: 27291:SPAR_I01930
uniprot id: A0A8B8UTN0
names: Similarity
messages: Belongs to the GST superfamily.

27291:SPAR O03020
gene id: 27291:SPAR_O03020
uniprot id: A0A8B8V011
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR D06250
gene id: 27291:SPAR_D06250
uniprot id: A0A8B8UPF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the SRB8-11 complex, which itself associates with the Mediator complex.
messages: Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.
messages: Nucleus

27291:SPAR M03990
gene id: 27291:SPAR_M03990
uniprot id: A0A8B8UXZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku70 family.
messages: Nucleus
messages: telomere

27291:SPAR M03400
gene id: 27291:SPAR_M03400
uniprot id: A0A8B8UXP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRE11/RAD32 family.
messages: Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
messages: Nucleus

27291:SPAR L02220
gene id: 27291:SPAR_L02220
uniprot id: A0A8B8UW63
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR M01330
gene id: 27291:SPAR_M01330
uniprot id: A0A8B8UX25
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
messages: Cytoplasm
messages: Nucleus

27291:SPAR A00800
gene id: 27291:SPAR_A00800
uniprot id: A0A8B8UL44
names: Similarity
messages: Belongs to the flocculin family.

27291:SPAR B00590
gene id: 27291:SPAR_B00590
uniprot id: A0A8B8ULA9
names: Similarity
messages: Belongs to the PPP4R2 family.

27291:SPAR L03060
gene id: 27291:SPAR_L03060
uniprot id: A0A8B8UW83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.

27291:SPAR L02330
gene id: 27291:SPAR_L02330
uniprot id: A0A8B8UW15
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

27291:SPAR N02700
gene id: 27291:SPAR_N02700
uniprot id: A0A8B8UYQ6
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

27291:SPAR M04370
gene id: 27291:SPAR_M04370
uniprot id: A0A8B8UXX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

27291:SPAR C01050
gene id: 27291:SPAR_C01050
uniprot id: A0A8B8UMK9
names: Similarity
messages: Belongs to the threonine synthase family.

27291:SPAR B01100
gene id: 27291:SPAR_B01100
uniprot id: A0A8B8ULG7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

27291:SPAR F00600
gene id: 27291:SPAR_F00600
uniprot id: A0A8B8UQP1
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

27291:SPAR E02360
gene id: 27291:SPAR_E02360
uniprot id: A0A8B8UQE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPC family.
messages: Nucleus

27291:SPAR P03350
gene id: 27291:SPAR_P03350
uniprot id: A0A8B8V1F1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.
messages: Nucleus

27291:SPAR O03000
gene id: 27291:SPAR_O03000
uniprot id: A0A8B8UZW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HIT family.
messages: Cytoplasm

27291:SPAR L01050
gene id: 27291:SPAR_L01050
uniprot id: A0A8B8UVU0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR P02700
gene id: 27291:SPAR_P02700
uniprot id: A0A8B8V186
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR D02900
gene id: 27291:SPAR_D02900
uniprot id: A0A8B8UNI2
names: Similarity
messages: In the C-terminal section; belongs to the trehalose phosphatase family.
messages: In the N-terminal section; belongs to the glycosyltransferase 20 family.

27291:SPAR G03980
gene id: 27291:SPAR_G03980
uniprot id: A0A8B8URV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

27291:SPAR O01180
gene id: 27291:SPAR_O01180
uniprot id: A0A8B8UZD1
names: Similarity
names: Subunit
messages: Belongs to the SIL1 family.
messages: Interacts with KAR2.

27291:SPAR I01170
gene id: 27291:SPAR_I01170
uniprot id: A0A8B8UT99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

27291:SPAR E00860
gene id: 27291:SPAR_E00860
uniprot id: A0A8B8UPY6
names: Similarity
messages: Belongs to the MAPRE family.

27291:SPAR O03290
gene id: 27291:SPAR_O03290
uniprot id: A0A8B8V034
names: Similarity
messages: Belongs to the NOC2 family.

27291:SPAR D06470
gene id: 27291:SPAR_D06470
uniprot id: A0A8B8UPI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

27291:SPAR L04160
gene id: 27291:SPAR_L04160
uniprot id: A0A8B8UWJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytoskeleton

27291:SPAR M02740
gene id: 27291:SPAR_M02740
uniprot id: A0A8B8UXM4
names: Similarity
messages: Belongs to the ATG16 family.

27291:SPAR L00150
gene id: 27291:SPAR_L00150
uniprot id: A0A8B8UVJ8
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR G04240
gene id: 27291:SPAR_G04240
uniprot id: A0A8B8US82
names: Similarity
messages: Belongs to the ZPR1 family.

27291:SPAR L03570
gene id: 27291:SPAR_L03570
uniprot id: A0A8B8UWJ9
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

27291:SPAR L01950
gene id: 27291:SPAR_L01950
uniprot id: A0A8B8UW34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP core protein family.
messages: Nucleus
messages: cytosol

27291:SPAR O02760
gene id: 27291:SPAR_O02760
uniprot id: A0A8B8UZU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM31/MDM32 family.
messages: Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR H00490
gene id: 27291:SPAR_H00490
uniprot id: A0A8B8USD1
names: Similarity
messages: Belongs to the cytochrome P450 family.

27291:SPAR O01960
gene id: 27291:SPAR_O01960
uniprot id: A0A8B8UZL4
names: Similarity
messages: Belongs to the SGT1 family.

27291:SPAR M01770
gene id: 27291:SPAR_M01770
uniprot id: A0A8B8UX65
names: Similarity
messages: Belongs to the multicopper oxidase family.

27291:SPAR D02830
gene id: 27291:SPAR_D02830
uniprot id: A0A8B8UNT8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

27291:SPAR E02590
gene id: 27291:SPAR_E02590
uniprot id: A0A8B8UQF5
names: Similarity
messages: Belongs to the lipid-translocating exporter (LTE) (TC 9.A.26.1) family.

27291:SPAR N02990
gene id: 27291:SPAR_N02990
uniprot id: A0A8B8UYT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL27 family.
messages: Mitochondrion

27291:SPAR D00470
gene id: 27291:SPAR_D00470
uniprot id: A0A8B8UMR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR O01440
gene id: 27291:SPAR_O01440
uniprot id: A0A8B8UZJ8
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR H00840
gene id: 27291:SPAR_H00840
uniprot id: A0A8B8USG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 20 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Nucleus

27291:SPAR O03410
gene id: 27291:SPAR_O03410
uniprot id: A0A8B8V002
names: Similarity
messages: Belongs to the peptidase S9B family.

27291:SPAR O02500
gene id: 27291:SPAR_O02500
uniprot id: A0A8B8UZQ7
names: Similarity
messages: Belongs to the AAA ATPase family.

27291:SPAR D03960
gene id: 27291:SPAR_D03960
uniprot id: A0A8B8UNT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.
messages: Nucleus

27291:SPAR D01740
gene id: 27291:SPAR_D01740
uniprot id: A0A8B8UN68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAD52 family.
messages: Interacts with RAD51 and RAD52.
messages: Involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing. Anneals complementary single-stranded DNA.
messages: Nucleus

27291:SPAR D03710
gene id: 27291:SPAR_D03710
uniprot id: A0A8B8UNR1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat TRM82 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA, a modification required to maintain stability of tRNAs; its absence resulting in tRNA decay. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

27291:SPAR D05050
gene id: 27291:SPAR_D05050
uniprot id: A0A8B8UP49
names: Similarity
messages: Belongs to the XPC family.

27291:SPAR P00230
gene id: 27291:SPAR_P00230
uniprot id: A0A8B8V0H4
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR J02290
gene id: 27291:SPAR_J02290
uniprot id: A0A8B8UU69
names: Function
names: PTM
names: Similarity
messages: Belongs to the eIF-5A family.
messages: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.

27291:SPAR H00310
gene id: 27291:SPAR_H00310
uniprot id: A0A8B8USD4
names: Function
names: Similarity
messages: 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

27291:SPAR G00630
gene id: 27291:SPAR_G00630
uniprot id: A0A8B8UQW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Nucleus

27291:SPAR M00460
gene id: 27291:SPAR_M00460
uniprot id: A0A8B8UWY8
names: Similarity
messages: Belongs to the tubulin family.

27291:SPAR P03980
gene id: 27291:SPAR_P03980
uniprot id: A0A8B8V1K0
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR I01900
gene id: 27291:SPAR_I01900
uniprot id: A0A8B8UTG8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

27291:SPAR G04840
gene id: 27291:SPAR_G04840
uniprot id: A0A8B8USE2
names: Similarity
messages: Belongs to the CWC22 family.

27291:SPAR K03060
gene id: 27291:SPAR_K03060
uniprot id: A0A8B8UVI1
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR M01110
gene id: 27291:SPAR_M01110
uniprot id: A0A8B8UX52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-Z subfamily.
messages: Cytoplasm

27291:SPAR G03090
gene id: 27291:SPAR_G03090
uniprot id: A0A8B8URX7
names: Function
names: Similarity
messages: Belongs to the catalase family.
messages: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.

27291:SPAR L04040
gene id: 27291:SPAR_L04040
uniprot id: A0A8B8UWM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR I00540
gene id: 27291:SPAR_I00540
uniprot id: A0A8B8UT73
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

27291:SPAR F00570
gene id: 27291:SPAR_F00570
uniprot id: A0A8B8UQV7
names: Subcellular Location Annotation
messages: Membrane
messages: Vacuole membrane

27291:SPAR B01280
gene id: 27291:SPAR_B01280
uniprot id: A0A8B8ULV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCO1/2 family.
messages: Mitochondrion inner membrane

27291:SPAR D04740
gene id: 27291:SPAR_D04740
uniprot id: A0A8B8UP11
names: Similarity
messages: Belongs to the RMD1/sif2 family.

27291:SPAR D07100
gene id: 27291:SPAR_D07100
uniprot id: A0A8B8UPP7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiD family. UbiD-like/FDC subfamily.
messages: Binds 1 prenylated FMN (prenyl-FMN) per subunit.
messages: Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4-vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites.
messages: Cytoplasm
messages: Homodimer. May form higher order oligomers.

27291:SPAR A00240
gene id: 27291:SPAR_A00240
uniprot id: A0A8B8UKV9
names: Similarity
messages: Belongs to the cyclin family.

27291:SPAR L01560
gene id: 27291:SPAR_L01560
uniprot id: A0A8B8UVT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC45 family.
messages: Nucleus

27291:SPAR B00280
gene id: 27291:SPAR_B00280
uniprot id: A0A8B8ULK2
names: Function
names: Subcellular Location Annotation
messages: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR N03480
gene id: 27291:SPAR_N03480
uniprot id: A0A8B8UZ32
names: Similarity
messages: Belongs to the TRM112 family.

27291:SPAR D04300
gene id: 27291:SPAR_D04300
uniprot id: A0A8B8UNX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.
messages: Mitochondrion matrix

27291:SPAR H01360
gene id: 27291:SPAR_H01360
uniprot id: A0A8B8USP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR D01320
gene id: 27291:SPAR_D01320
uniprot id: A0A8B8UN06
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE4 family.
messages: Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
messages: Component of the SMC5-SMC6 complex.
messages: Nucleus

27291:SPAR M04340
gene id: 27291:SPAR_M04340
uniprot id: A0A8B8UY30
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

27291:SPAR H01100
gene id: 27291:SPAR_H01100
uniprot id: A0A8B8USM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP4 family.
messages: Cytoplasm

27291:SPAR E02260
gene id: 27291:SPAR_E02260
uniprot id: A0A8B8UQD0
names: Similarity
messages: Belongs to the peptidase C19 family.

27291:SPAR L01800
gene id: 27291:SPAR_L01800
uniprot id: A0A8B8UW18
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 2H phosphoesterase superfamily. USB1 family.
messages: Nucleus
messages: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.

27291:SPAR D06600
gene id: 27291:SPAR_D06600
uniprot id: A0A8B8UPJ6
names: Similarity
messages: Belongs to the CWC21 family.

27291:SPAR J00730
gene id: 27291:SPAR_J00730
uniprot id: A0A8B8UTV3
names: Function
names: Similarity
messages: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.

27291:SPAR P01720
gene id: 27291:SPAR_P01720
uniprot id: A0A8B8V0X6
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

27291:SPAR N01830
gene id: 27291:SPAR_N01830
uniprot id: A0A8B8UYL5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
messages: Interacts with TAN1.
messages: RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
messages: nucleolus

27291:SPAR K00450
gene id: 27291:SPAR_K00450
uniprot id: A0A8B8UUM0
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR M01120
gene id: 27291:SPAR_M01120
uniprot id: A0A8B8UX00
names: Similarity
messages: Belongs to the TAF11 family.

27291:SPAR E01110
gene id: 27291:SPAR_E01110
uniprot id: A0A8B8UQ16
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR D01080
gene id: 27291:SPAR_D01080
uniprot id: A0A8B8UNA9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.

27291:SPAR M01620
gene id: 27291:SPAR_M01620
uniprot id: A0A8B8UX53
names: Similarity
messages: Belongs to the CCS1 family.

27291:SPAR P00590
gene id: 27291:SPAR_P00590
uniprot id: A0A8B8V0R2
names: Subcellular Location Annotation
messages: nucleolus

27291:SPAR O01520
gene id: 27291:SPAR_O01520
uniprot id: A0A8B8UZL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

27291:SPAR F00070
gene id: 27291:SPAR_F00070
uniprot id: A0A8B8UQR0
names: Function
names: Similarity
messages: Belongs to the dihydroxyacetone kinase (DAK) family.
messages: Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.

27291:SPAR D06670
gene id: 27291:SPAR_D06670
uniprot id: A0A8B8UPK4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS4/SLD5 family.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

27291:SPAR F00540
gene id: 27291:SPAR_F00540
uniprot id: A0A8B8UQN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC1 subfamily.
messages: Nucleus

27291:SPAR E02170
gene id: 27291:SPAR_E02170
uniprot id: A0A8B8UQA5
names: Similarity
messages: Belongs to the alkylbase DNA glycosidase AlkA family.

27291:SPAR K00390
gene id: 27291:SPAR_K00390
uniprot id: A0A8B8UUK7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the fungal fatty acid synthetase subunit beta family.
messages: Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.
messages: [Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).

27291:SPAR I00500
gene id: 27291:SPAR_I00500
uniprot id: A0A8B8UT22
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR O04400
gene id: 27291:SPAR_O04400
uniprot id: A0A8B8V0A3
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm
messages: Mitochondrion
messages: Monomer.

27291:SPAR G01000
gene id: 27291:SPAR_G01000
uniprot id: A0A8B8UR18
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Component of the INO80 chromatin-remodeling complex.
messages: Nucleus
messages: The DBINO region is involved in binding to DNA.

27291:SPAR O00590
gene id: 27291:SPAR_O00590
uniprot id: A0A8B8UZB6
names: Similarity
messages: Belongs to the activator 1 small subunits family.

27291:SPAR K01650
gene id: 27291:SPAR_K01650
uniprot id: A0A8B8UUZ0
names: Similarity
messages: Belongs to the glycosyl hydrolase 76 family.

27291:SPAR M04080
gene id: 27291:SPAR_M04080
uniprot id: A0A8B8UXV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A, B and F subunits.

27291:SPAR G00410
gene id: 27291:SPAR_G00410
uniprot id: A0A8B8UQZ4
names: Similarity
messages: Belongs to the BolA/IbaG family.

27291:SPAR D01030
gene id: 27291:SPAR_D01030
uniprot id: A0A8B8UNA3
names: Similarity
messages: Belongs to the PPP phosphatase family.

27291:SPAR H00650
gene id: 27291:SPAR_H00650
uniprot id: A0A8B8USH4
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

27291:SPAR N02480
gene id: 27291:SPAR_N02480
uniprot id: A0A8B8UYT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: nucleolus

27291:SPAR I01360
gene id: 27291:SPAR_I01360
uniprot id: A0A8B8UTJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

27291:SPAR M00930
gene id: 27291:SPAR_M00930
uniprot id: A0A8B8UWY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CGI121/TPRKB family.
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification.

27291:SPAR D02180
gene id: 27291:SPAR_D02180
uniprot id: A0A8B8UNL8
names: Similarity
messages: Belongs to the PP2C family.

27291:SPAR G02380
gene id: 27291:SPAR_G02380
uniprot id: A0A8B8URE9
names: Similarity
messages: Belongs to the PRP18 family.

27291:SPAR K01600
gene id: 27291:SPAR_K01600
uniprot id: A0A8B8UUY5
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR G00040
gene id: 27291:SPAR_G00040
uniprot id: A0A8B8UR21
names: Similarity
messages: Belongs to the MNN1/MNT family.

27291:SPAR H00680
gene id: 27291:SPAR_H00680
uniprot id: A0A8B8USM1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.

27291:SPAR M03290
gene id: 27291:SPAR_M03290
uniprot id: A0A8B8UXS9
names: Similarity
messages: Belongs to the CEF1 family.

27291:SPAR M02690
gene id: 27291:SPAR_M02690
uniprot id: A0A8B8UXL9
names: Similarity
messages: Belongs to the peptidase C2 family. PalB/RIM13 subfamily.

27291:SPAR B02110
gene id: 27291:SPAR_B02110
uniprot id: A0A8B8ULQ6
names: Function
messages: Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.

27291:SPAR B01760
gene id: 27291:SPAR_B01760
uniprot id: A0A8B8ULM4
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR D04720
gene id: 27291:SPAR_D04720
uniprot id: A0A8B8UNZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: Cytoplasm
messages: nucleolus

27291:SPAR B03630
gene id: 27291:SPAR_B03630
uniprot id: A0A8B8UMH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the REI1 family.
messages: Cytoplasm

27291:SPAR B00930
gene id: 27291:SPAR_B00930
uniprot id: A0A8B8ULS0
names: Similarity
messages: Belongs to the Fmt family.

27291:SPAR P02400
gene id: 27291:SPAR_P02400
uniprot id: A0A8B8V156
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

27291:SPAR G01250
gene id: 27291:SPAR_G01250
uniprot id: A0A8B8UR43
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

27291:SPAR C00520
gene id: 27291:SPAR_C00520
uniprot id: A0A8B8UME2
names: Similarity
messages: Belongs to the acetolactate synthase small subunit family.

27291:SPAR D05600
gene id: 27291:SPAR_D05600
uniprot id: A0A8B8UPA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Membrane

27291:SPAR N03440
gene id: 27291:SPAR_N03440
uniprot id: A0A8B8UYX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
messages: Mitochondrion inner membrane

27291:SPAR D02110
gene id: 27291:SPAR_D02110
uniprot id: A0A8B8UNA1
names: Similarity
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.

27291:SPAR P01470
gene id: 27291:SPAR_P01470
uniprot id: A0A8B8V0V1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPC29 family.
messages: Component of the SPC110 complex containing at least CMD1, SPC29, SPC42 and SCP110. Interacts with BBP1.
messages: Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication. Links the central plaque component SPC42 to the inner plaque component SPC110.
messages: Nucleus
messages: spindle pole body

27291:SPAR K01960
gene id: 27291:SPAR_K01960
uniprot id: A0A8B8UV70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARPC4 family.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
messages: actin patch

27291:SPAR D03770
gene id: 27291:SPAR_D03770
uniprot id: A0A8B8UNQ2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

27291:SPAR G02310
gene id: 27291:SPAR_G02310
uniprot id: A0A8B8URI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

27291:SPAR P03640
gene id: 27291:SPAR_P03640
uniprot id: A0A8B8V1L8
names: Function
names: Similarity
messages: Belongs to the RRG8 family.
messages: Required for respiratory activity and maintenance and expression of the mitochondrial genome.

27291:SPAR G00980
gene id: 27291:SPAR_G00980
uniprot id: A0A8B8UR07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-14 family.
messages: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
messages: Peroxisome membrane

27291:SPAR A00260
gene id: 27291:SPAR_A00260
uniprot id: A0A8B8UKW4
names: Similarity
names: Subunit
messages: Belongs to the pyruvate kinase family.
messages: Homotetramer.

27291:SPAR I00670
gene id: 27291:SPAR_I00670
uniprot id: A0A8B8UT49
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.

27291:SPAR M00040
gene id: 27291:SPAR_M00040
uniprot id: A0A8B8UWW3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EROs family.
messages: Endoplasmic reticulum membrane
messages: May function both as a monomer and a homodimer.

27291:SPAR L00860
gene id: 27291:SPAR_L00860
uniprot id: A0A8B8UXC5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

27291:SPAR O01820
gene id: 27291:SPAR_O01820
uniprot id: A0A8B8UZP3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Regulatory subunit of casein kinase II/CK2 (By similarity). As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.
messages: Tetramer of two alpha and two beta subunits.

27291:SPAR O02720
gene id: 27291:SPAR_O02720
uniprot id: A0A8B8UZY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

27291:SPAR D01230
gene id: 27291:SPAR_D01230
uniprot id: A0A8B8UNC4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

27291:SPAR B02230
gene id: 27291:SPAR_B02230
uniprot id: A0A8B8UM44
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR N02770
gene id: 27291:SPAR_N02770
uniprot id: A0A8B8UYR2
names: Similarity
messages: Belongs to the glycosyltransferase 15 family.

27291:SPAR P02770
gene id: 27291:SPAR_P02770
uniprot id: A0A8B8V185
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by the GTPase RIA1/EFL1 and by SDO1. Also required for pre-rRNA processing.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit.
messages: Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
messages: nucleolus

27291:SPAR B03540
gene id: 27291:SPAR_B03540
uniprot id: A0A8B8UM64
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.

27291:SPAR M00100
gene id: 27291:SPAR_M00100
uniprot id: A0A8B8UWQ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

27291:SPAR M00020
gene id: 27291:SPAR_M00020
uniprot id: A0A8B8UWP6
names: Similarity
messages: Belongs to the peptidase S33 family.

27291:A560 mgp04
gene id: 27291:A560_mgp04
uniprot id: I1Z689
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR D05930
gene id: 27291:SPAR_D05930
uniprot id: A0A8B8UPN8
names: Similarity
messages: Belongs to the universal ribosomal protein uL23 family.

27291:SPAR O04220
gene id: 27291:SPAR_O04220
uniprot id: A0A8B8V0D4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

27291:SPAR D04130
gene id: 27291:SPAR_D04130
uniprot id: A0A8B8UP66
names: Function
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.

27291:SPAR B03200
gene id: 27291:SPAR_B03200
uniprot id: A0A8B8UM27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosyl-DNA phosphodiesterase family.
messages: Nucleus

27291:SPAR I01620
gene id: 27291:SPAR_I01620
uniprot id: A0A8B8UTE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAN1 family.
messages: Cell membrane
messages: Endosome membrane
messages: Membrane
messages: actin patch

27291:SPAR D06390
gene id: 27291:SPAR_D06390
uniprot id: A0A8B8UPT1
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

27291:SPAR C00210
gene id: 27291:SPAR_C00210
uniprot id: A0A8B8UMB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPS2 family.
messages: Cell membrane
messages: Membrane

27291:SPAR E01980
gene id: 27291:SPAR_E01980
uniprot id: A0A8B8UQJ3
names: Similarity
messages: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.

27291:SPAR K00440
gene id: 27291:SPAR_K00440
uniprot id: A0A8B8UUL4
names: Similarity
messages: Belongs to the LST4 family.

27291:SPAR M01700
gene id: 27291:SPAR_M01700
uniprot id: A0A8B8UX66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSM3 family.
messages: Component of the fork protection complex (FPC) consisting of TOF1 and CSM3.
messages: Nucleus
messages: Plays an important role in the control of DNA replication and the maintenance of replication fork stability.

27291:SPAR G03530
gene id: 27291:SPAR_G03530
uniprot id: A0A8B8URQ9
names: Function
names: Similarity
messages: Belongs to the peptidase T1A family.
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

27291:SPAR C00110
gene id: 27291:SPAR_C00110
uniprot id: A0A8B8UMA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic10 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

27291:SPAR G00670
gene id: 27291:SPAR_G00670
uniprot id: A0A8B8UR14
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.

27291:SPAR G04820
gene id: 27291:SPAR_G04820
uniprot id: A0A8B8US81
names: Similarity
messages: Belongs to the REXO1/REXO3 family.

27291:SPAR K01090
gene id: 27291:SPAR_K01090
uniprot id: A0A8B8UUS8
names: Function
messages: Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).

27291:SPAR D01970
gene id: 27291:SPAR_D01970
uniprot id: A0A8B8UN70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
messages: Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.
messages: nucleolus

27291:SPAR M02210
gene id: 27291:SPAR_M02210
uniprot id: A0A8B8UXF7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

27291:SPAR D00540
gene id: 27291:SPAR_D00540
uniprot id: A0A8B8UMV1
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

27291:SPAR E02160
gene id: 27291:SPAR_E02160
uniprot id: A0A8B8UQC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

27291:SPAR H00660
gene id: 27291:SPAR_H00660
uniprot id: A0A8B8USG9
names: Similarity
messages: Belongs to the peptidase M16 family.

27291:SPAR M03160
gene id: 27291:SPAR_M03160
uniprot id: A0A8B8UXQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ROT1 family.
messages: Endoplasmic reticulum membrane
messages: Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies.

27291:SPAR D04980
gene id: 27291:SPAR_D04980
uniprot id: A0A8B8UPE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR G01910
gene id: 27291:SPAR_G01910
uniprot id: A0A8B8URE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 28 family.
messages: Endoplasmic reticulum
messages: Heterodimer with ALG14 to form a functional enzyme.
messages: Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.

27291:SPAR C00600
gene id: 27291:SPAR_C00600
uniprot id: A0A8B8UMG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck

27291:SPAR G03110
gene id: 27291:SPAR_G03110
uniprot id: A0A8B8URR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAP family.
messages: nucleolus

27291:SPAR O03850
gene id: 27291:SPAR_O03850
uniprot id: A0A8B8V052
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane
messages: Mitochondrion membrane

27291:SPAR D01620
gene id: 27291:SPAR_D01620
uniprot id: A0A8B8UN35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BRE1 family.
messages: Nucleus

27291:SPAR I00250
gene id: 27291:SPAR_I00250
uniprot id: A0A8B8USZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

27291:SPAR E02440
gene id: 27291:SPAR_E02440
uniprot id: A0A8B8UQD9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
messages: Mitochondrion matrix
messages: Monomer.

27291:SPAR G04530
gene id: 27291:SPAR_G04530
uniprot id: A0A8B8US10
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

27291:SPAR F00740
gene id: 27291:SPAR_F00740
uniprot id: A0A8B8UQQ8
names: Similarity
messages: Belongs to the protein kinase superfamily.

27291:SPAR K01270
gene id: 27291:SPAR_K01270
uniprot id: A0A8B8UUU3
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.

27291:SPAR P00050
gene id: 27291:SPAR_P00050
uniprot id: A0A8B8V0G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

27291:SPAR K00430
gene id: 27291:SPAR_K00430
uniprot id: Q8J0B0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 4 family.
messages: Membrane

27291:SPAR H00790
gene id: 27291:SPAR_H00790
uniprot id: A0A8B8USF9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

27291:SPAR G00570
gene id: 27291:SPAR_G00570
uniprot id: A0A8B8UR05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

27291:SPAR J00260
gene id: 27291:SPAR_J00260
uniprot id: A0A8B8UTS2
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR P03390
gene id: 27291:SPAR_P03390
uniprot id: A0A8B8V1J3
names: Similarity
messages: Belongs to the TFIIB family.

27291:SPAR D02960
gene id: 27291:SPAR_D02960
uniprot id: A0A8B8UNI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB5 family.
messages: Component of the 7-subunit TFIIH core complex.
messages: In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.
messages: Nucleus

27291:SPAR G04640
gene id: 27291:SPAR_G04640
uniprot id: A0A8B8USC2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiH/COQ6 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-hexaprenyl-4-hydroxybenzoic acid (HHB) to 3-hexaprenyl-4,5-dihydroxybenzoic acid (DHHB). The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via ferredoxin (YAH1) and ferredoxin reductase (ARH1) to COQ6. Can also convert 3-hexaprenyl-4-aminobenzoic acid (HAB), a COQ2-prenylated pABA, to DHHB in a two step process. HAB is first hydroxylated at C5 to yield 3-hexaprenyl-4-amino-5-hydroxybenzoic acid (HHAB) which is further deaminated at C4 by COQ6 to produce DHHB.
messages: Mitochondrion inner membrane

27291:SPAR D04170
gene id: 27291:SPAR_D04170
uniprot id: A0A8B8UNT9
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR C00630
gene id: 27291:SPAR_C00630
uniprot id: A0A8B8UMD4
names: Similarity
messages: Belongs to the citrate synthase family.

27291:SPAR L01910
gene id: 27291:SPAR_L01910
uniprot id: A0A8B8UVW9
names: Similarity
messages: Belongs to the glycosyl hydrolase 81 family.

27291:SPAR N03120
gene id: 27291:SPAR_N03120
uniprot id: A0A8B8UYU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 9 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

27291:SPAR P00330
gene id: 27291:SPAR_P00330
uniprot id: A0A8B8V0I4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR B02410
gene id: 27291:SPAR_B02410
uniprot id: A0A8B8ULT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BMT2 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine 2142 in 25S rRNA. N(1)-methyladenine(2142) in 25S rRNA is present in helix 65, a region that accounts for most of the intersubunit surface of the large subunit.
messages: nucleolus

27291:SPAR G03940
gene id: 27291:SPAR_G03940
uniprot id: A0A8B8US57
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

27291:SPAR G01720
gene id: 27291:SPAR_G01720
uniprot id: A0A8B8URC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

27291:SPAR B02020
gene id: 27291:SPAR_B02020
uniprot id: A0A8B8ULL9
names: Similarity
messages: Belongs to the FES1 family.

27291:SPAR N02420
gene id: 27291:SPAR_N02420
uniprot id: A0A8B8UYN0
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

27291:SPAR E00900
gene id: 27291:SPAR_E00900
uniprot id: A0A8B8UQ01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC61-beta family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR G04950
gene id: 27291:SPAR_G04950
uniprot id: A0A8B8US73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR A00320
gene id: 27291:SPAR_A00320
uniprot id: A0A8B8UKP6
names: Function
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

27291:SPAR D00040
gene id: 27291:SPAR_D00040
uniprot id: A0A8B8UMQ1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

27291:SPAR E01720
gene id: 27291:SPAR_E01720
uniprot id: A0A8B8UQ57
names: Similarity
messages: Belongs to the RICTOR family.

27291:SPAR B02920
gene id: 27291:SPAR_B02920
uniprot id: A0A8B8ULW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 8 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

27291:SPAR L03400
gene id: 27291:SPAR_L03400
uniprot id: A0A8B8UWC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the CWC24 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

27291:SPAR C00680
gene id: 27291:SPAR_C00680
uniprot id: A0A8B8UMD9
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

27291:SPAR E00350
gene id: 27291:SPAR_E00350
uniprot id: A0A8B8UPU8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

27291:SPAR F00870
gene id: 27291:SPAR_F00870
uniprot id: A0A8B8UQY7
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.

27291:SPAR L01630
gene id: 27291:SPAR_L01630
uniprot id: A0A8B8UVT9
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR G04740
gene id: 27291:SPAR_G04740
uniprot id: A0A8B8USD2
names: Similarity
messages: Belongs to the GTP cyclohydrolase I family.

27291:SPAR H02530
gene id: 27291:SPAR_H02530
uniprot id: A0A8B8USW4
names: Similarity
messages: Belongs to the flocculin family.

27291:SPAR B02980
gene id: 27291:SPAR_B02980
uniprot id: A0A8B8UMB8
names: Similarity
messages: Belongs to the glycosyltransferase 15 family.

27291:SPAR J03130
gene id: 27291:SPAR_J03130
uniprot id: A0A8B8UUJ5
names: Similarity
messages: Belongs to the TTI2 family.

27291:SPAR M03640
gene id: 27291:SPAR_M03640
uniprot id: A0A8B8UXW4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LTN1 family.
messages: Component of the ribosome quality control complex (RQC).
messages: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
messages: cytosol

27291:SPAR B02380
gene id: 27291:SPAR_B02380
uniprot id: A0A8B8UM59
names: Similarity
messages: Belongs to the peptidase S10 family.

27291:SPAR G03870
gene id: 27291:SPAR_G03870
uniprot id: A0A8B8URZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Golgi apparatus membrane
messages: Membrane

27291:SPAR D06630
gene id: 27291:SPAR_D06630
uniprot id: A0A8B8UPI9
names: Similarity
messages: Belongs to the VPS72/YL1 family.

27291:SPAR D01810
gene id: 27291:SPAR_D01810
uniprot id: A0A8B8UN71
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

27291:SPAR N03090
gene id: 27291:SPAR_N03090
uniprot id: A0A8B8UYU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG3 family.
messages: Cytoplasm

27291:SPAR N00630
gene id: 27291:SPAR_N00630
uniprot id: A0A8B8UY48
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

27291:SPAR E02200
gene id: 27291:SPAR_E02200
uniprot id: A0A8B8UQE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

27291:SPAR D01480
gene id: 27291:SPAR_D01480
uniprot id: A0A8B8UNE9
names: Similarity
messages: Belongs to the Luc7 family.

27291:SPAR F00240
gene id: 27291:SPAR_F00240
uniprot id: A0A8B8UQK9
names: Function
names: Similarity
messages: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
messages: Belongs to the actin family.

27291:SPAR E00500
gene id: 27291:SPAR_E00500
uniprot id: A0A8B8UPW3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

27291:SPAR K02110
gene id: 27291:SPAR_K02110
uniprot id: A0A8B8UV86
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the poly(A) polymerase family.
messages: Binds 2 magnesium ions. Also active with manganese.
messages: Nucleus
messages: Polymerase that creates the 3'-poly(A) tail of mRNA's.

27291:SPAR D01400
gene id: 27291:SPAR_D01400
uniprot id: A0A8B8UN33
names: Similarity
messages: Belongs to the proteasome subunit S9 family.

27291:SPAR G02340
gene id: 27291:SPAR_G02340
uniprot id: A0A8B8URQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWC4 family.
messages: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
messages: Nucleus

27291:SPAR P02980
gene id: 27291:SPAR_P02980
uniprot id: A0A8B8V1A4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

27291:SPAR G02040
gene id: 27291:SPAR_G02040
uniprot id: A0A8B8URL9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

27291:SPAR J00440
gene id: 27291:SPAR_J00440
uniprot id: A0A8B8UTP8
names: Similarity
messages: Belongs to the PGA52 family.

27291:SPAR L00310
gene id: 27291:SPAR_L00310
uniprot id: A0A8B8UVF6
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR L03390
gene id: 27291:SPAR_L03390
uniprot id: A0A8B8UWF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF5 family.
messages: Nucleus
messages: Part of the chromatin structure-remodeling complex (RSC) which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is essential for mitotic growth and required for cell cycle progression.

27291:SPAR O03600
gene id: 27291:SPAR_O03600
uniprot id: A0A8B8V029
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

27291:SPAR G00860
gene id: 27291:SPAR_G00860
uniprot id: A0A8B8UR39
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR L02890
gene id: 27291:SPAR_L02890
uniprot id: A0A8B8UWB2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

27291:SPAR J02240
gene id: 27291:SPAR_J02240
uniprot id: A0A8B8UU64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup85 family.
messages: Component of the nuclear pore complex (NPC).
messages: Functions as a component of the nuclear pore complex (NPC).
messages: nuclear pore complex

27291:SPAR M02800
gene id: 27291:SPAR_M02800
uniprot id: A0A8B8UXI4
names: Similarity
messages: Belongs to the lipin family.

27291:SPAR M00110
gene id: 27291:SPAR_M00110
uniprot id: A0A8B8UWU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR A00200
gene id: 27291:SPAR_A00200
uniprot id: A0A8B8UKX1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

27291:SPAR M00760
gene id: 27291:SPAR_M00760
uniprot id: A0A8B8UX17
names: Similarity
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.
messages: Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

27291:SPAR J01430
gene id: 27291:SPAR_J01430
uniprot id: A0A8B8UU16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the battenin family.
messages: Membrane
messages: Vacuole membrane

27291:SPAR N00770
gene id: 27291:SPAR_N00770
uniprot id: A0A8B8UYA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL46 family.
messages: Mitochondrion

27291:SPAR O03830
gene id: 27291:SPAR_O03830
uniprot id: A0A8B8V047
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck.
messages: Self-associates. Interacts with NDL1 and dynein.
messages: cytoskeleton
messages: spindle pole

27291:SPAR B03150
gene id: 27291:SPAR_B03150
uniprot id: A0A8B8UM22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG12 family.
messages: Forms a conjugate with ATG5.
messages: Membrane
messages: Preautophagosomal structure membrane
messages: Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.

27291:SPAR N00050
gene id: 27291:SPAR_N00050
uniprot id: A0A8B8UY44
names: Similarity
messages: Belongs to the PdxS/SNZ family.

27291:SPAR D05130
gene id: 27291:SPAR_D05130
uniprot id: A0A8B8UPG3
names: Similarity
messages: Belongs to the asparaginase 1 family.

27291:SPAR D04630
gene id: 27291:SPAR_D04630
uniprot id: A0A8B8UPB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat CIA1 family.
messages: Cytoplasm
messages: Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.
messages: Interacts with NAR1.
messages: Nucleus

27291:SPAR D06650
gene id: 27291:SPAR_D06650
uniprot id: A0A8B8UPK2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

27291:SPAR C00140
gene id: 27291:SPAR_C00140
uniprot id: A0A8B8UMM5
names: Similarity
messages: Belongs to the MT-A70-like family.

27291:SPAR G04690
gene id: 27291:SPAR_G04690
uniprot id: A0A8B8USC7
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

27291:SPAR G00240
gene id: 27291:SPAR_G00240
uniprot id: A0A8B8UR40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Heterotrimer.
messages: Nucleus

27291:SPAR G03120
gene id: 27291:SPAR_G03120
uniprot id: A0A8B8URR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP31 family.
messages: Nucleus

27291:SPAR I00800
gene id: 27291:SPAR_I00800
uniprot id: A0A8B8UT55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Vacuole membrane

27291:SPAR D02970
gene id: 27291:SPAR_D02970
uniprot id: A0A8B8UNH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS41 family.
messages: Required for vacuolar assembly and vacuolar traffic.
messages: Vacuole

27291:SPAR L01570
gene id: 27291:SPAR_L01570
uniprot id: A0A8B8UVY1
names: Similarity
messages: Belongs to the LCL2 family.

27291:SPAR K01460
gene id: 27291:SPAR_K01460
uniprot id: A0A8B8UV23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

27291:SPAR M03920
gene id: 27291:SPAR_M03920
uniprot id: A0A8B8UXT2
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: This promotes the activity of RNA polymerase II.

27291:SPAR J01890
gene id: 27291:SPAR_J01890
uniprot id: A0A8B8UU32
names: Subunit
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

27291:SPAR G02870
gene id: 27291:SPAR_G02870
uniprot id: A0A8B8URN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

27291:SPAR F00090
gene id: 27291:SPAR_F00090
uniprot id: A0A8B8UQJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR E02150
gene id: 27291:SPAR_E02150
uniprot id: A0A8B8UQD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAPT1 family.
messages: Membrane

27291:SPAR P04180
gene id: 27291:SPAR_P04180
uniprot id: A0A8B8V1M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase epsilon subunit B family.
messages: Nucleus

27291:SPAR B03300
gene id: 27291:SPAR_B03300
uniprot id: A0A8B8UM36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: actin patch

27291:SPAR G02700
gene id: 27291:SPAR_G02700
uniprot id: A0A8B8URI1
names: Function
names: Similarity
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.

27291:SPAR D01870
gene id: 27291:SPAR_D01870
uniprot id: A0A8B8UN60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS37 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Component of the mitochondrial small ribosomal subunit.
messages: Mitochondrion

27291:SPAR L02060
gene id: 27291:SPAR_L02060
uniprot id: A0A8B8UVY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Golgi apparatus

27291:SPAR H02120
gene id: 27291:SPAR_H02120
uniprot id: A0A8B8USX2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG7 family.
messages: Cytoplasm
messages: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.
messages: Homodimer.
messages: Preautophagosomal structure

27291:SPAR E02420
gene id: 27291:SPAR_E02420
uniprot id: A0A8B8UQC7
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

27291:SPAR N02090
gene id: 27291:SPAR_N02090
uniprot id: A0A8B8UYJ5
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

27291:SPAR E00790
gene id: 27291:SPAR_E00790
uniprot id: A0A8B8UPX7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

27291:SPAR B03680
gene id: 27291:SPAR_B03680
uniprot id: A0A8B8UMI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proteasome subunit S5B/HSM3 family.
messages: Cytoplasm
messages: Involved in DNA mismatch repair in slow-growing cells. Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC).

27291:SPAR L02000
gene id: 27291:SPAR_L02000
uniprot id: A0A8B8UW38
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR L01140
gene id: 27291:SPAR_L01140
uniprot id: A0A8B8UVP4
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

27291:SPAR D00890
gene id: 27291:SPAR_D00890
uniprot id: A0A8B8UMY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG9 family.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.
messages: Preautophagosomal structure membrane

27291:SPAR N03010
gene id: 27291:SPAR_N03010
uniprot id: A0A8B8UYZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

27291:SPAR M00440
gene id: 27291:SPAR_M00440
uniprot id: A0A8B8UWZ7
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

27291:SPAR O00320
gene id: 27291:SPAR_O00320
uniprot id: A0A8B8UZ91
names: Function
messages: Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.

27291:SPAR J00480
gene id: 27291:SPAR_J00480
uniprot id: A0A8B8UTS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCRQ/QCR8 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR G04700
gene id: 27291:SPAR_G04700
uniprot id: A0A8B8US39
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
messages: telomere

27291:SPAR E02510
gene id: 27291:SPAR_E02510
uniprot id: A0A8B8UQF9
names: Similarity
messages: Belongs to the 14-3-3 family.

27291:SPAR J02790
gene id: 27291:SPAR_J02790
uniprot id: A0A8B8UUB5
names: Similarity
messages: Belongs to the phospholipid scramblase family.

27291:SPAR P03020
gene id: 27291:SPAR_P03020
uniprot id: A0A8B8V1A9
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

27291:SPAR B03350
gene id: 27291:SPAR_B03350
uniprot id: A0A8B8UM41
names: Similarity
messages: Belongs to the ERT1/acuK family.

27291:SPAR N01160
gene id: 27291:SPAR_N01160
uniprot id: A0A8B8UYA7
names: Similarity
messages: Belongs to the heat shock protein 70 family.

27291:SPAR P03610
gene id: 27291:SPAR_P03610
uniprot id: A0A8B8V1K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

27291:SPAR G04550
gene id: 27291:SPAR_G04550
uniprot id: A0A8B8US19
names: Similarity
messages: Belongs to the TFIIB family.

27291:SPAR D06400
gene id: 27291:SPAR_D06400
uniprot id: A0A8B8UPH6
names: Function
names: Subcellular Location Annotation
messages: Acts as component of the general transcription and DNA repair factor IIH (TFIIH or factor B), which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA.
messages: Nucleus

27291:SPAR E00970
gene id: 27291:SPAR_E00970
uniprot id: A0A8B8UPY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

27291:SPAR M02650
gene id: 27291:SPAR_M02650
uniprot id: A0A8B8UXG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWP1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

27291:SPAR D07050
gene id: 27291:SPAR_D07050
uniprot id: A0A8B8UPP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KRE28 family.
messages: Component of the SPC105 complex composed of at least SPC105 and KRE28. The SPC105 complex interacts with the MIND and NDC80 complexes at the centromere.
messages: Forms a kinetochore complex with SPC105 which is required for kinetochore binding by a discrete subset of kMAPs (BIM1, BIK1 and SLK19) and motors (CIN8, KAR3). Involved in kinetochore-microtubule binding and the spindle assembly checkpoint.
messages: Nucleus membrane
messages: kinetochore
messages: spindle pole body

27291:SPAR G03700
gene id: 27291:SPAR_G03700
uniprot id: A0A8B8URT3
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

27291:SPAR G00950
gene id: 27291:SPAR_G00950
uniprot id: A0A8B8UR13
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.

27291:SPAR G00360
gene id: 27291:SPAR_G00360
uniprot id: A0A8B8UQY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TPT transporter family. SLC35D subfamily.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homooligomer.
messages: Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.
messages: Membrane

27291:SPAR M03970
gene id: 27291:SPAR_M03970
uniprot id: A0A8B8UXT7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AEP2 family.
messages: Binds to the 5'UTR of the OLI1 mRNA.
messages: Mitochondrion
messages: Required for translation of the mitochondrial OLI1 transcript coding for the mitochondrial ATP synthase subunit 9.

27291:SPAR J00140
gene id: 27291:SPAR_J00140
uniprot id: A0A8B8UTL9
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

27291:SPAR K00850
gene id: 27291:SPAR_K00850
uniprot id: A0A8B8UUR1
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

27291:SPAR D04480
gene id: 27291:SPAR_D04480
uniprot id: A0A8B8UPA0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAC-beta family.
messages: Cytoplasm
messages: Nucleus
messages: Part of the nascent polypeptide-associated complex (NAC).

27291:SPAR G01490
gene id: 27291:SPAR_G01490
uniprot id: A0A8B8URG2
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR G02790
gene id: 27291:SPAR_G02790
uniprot id: A0A8B8URU7
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

27291:SPAR B00090
gene id: 27291:SPAR_B00090
uniprot id: A0A8B8UL47
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

27291:SPAR B02760
gene id: 27291:SPAR_B02760
uniprot id: A0A8B8ULX2
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

27291:SPAR G03020
gene id: 27291:SPAR_G03020
uniprot id: A0A8B8URQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLX9 family.
messages: Interacts with the 35S, 23S and 20S pre-rRNAs and with the U3 snoRNA.
messages: Involved in ribosome biogenesis. Required for normal pre-rRNA processing in internal transcribed spacer 1 (ITS1). May be involved in the movements of the replication forks.
messages: nucleolus

27291:SPAR M02680
gene id: 27291:SPAR_M02680
uniprot id: A0A8B8UXF9
names: Subcellular Location Annotation
messages: nuclear pore complex

27291:SPAR D00130
gene id: 27291:SPAR_D00130
uniprot id: A0A8B8UN12
names: Cofactor
messages: Divalent metal ions. Mg(2+) is the most effective.

27291:SPAR D01980
gene id: 27291:SPAR_D01980
uniprot id: A0A8B8UNJ7
names: Similarity
messages: Belongs to the SF3A3 family.

27291:SPAR K03000
gene id: 27291:SPAR_K03000
uniprot id: A0A8B8UVC7
names: Similarity
messages: Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.

27291:SPAR M01320
gene id: 27291:SPAR_M01320
uniprot id: A0A8B8UX21
names: Similarity
messages: Belongs to the lysophospholipase family.

27291:SPAR O03060
gene id: 27291:SPAR_O03060
uniprot id: A0A8B8UZX2
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR J03200
gene id: 27291:SPAR_J03200
uniprot id: A0A8B8UUG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

27291:SPAR H01720
gene id: 27291:SPAR_H01720
uniprot id: A0A8B8USN4
names: Similarity
messages: Belongs to the peptidase M14 family.

27291:SPAR D06510
gene id: 27291:SPAR_D06510
uniprot id: A0A8B8UPK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: Part of the multisubunit TRAPP (transport protein particle) complex.
messages: Plays a key role in the late stages of endoplasmic reticulum to Golgi traffic.
messages: cis-Golgi network

27291:SPAR G04360
gene id: 27291:SPAR_G04360
uniprot id: A0A8B8US38
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR P00440
gene id: 27291:SPAR_P00440
uniprot id: A0A8B8V0P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

27291:SPAR M01990
gene id: 27291:SPAR_M01990
uniprot id: A0A8B8UXF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Cytoplasm

27291:SPAR G01240
gene id: 27291:SPAR_G01240
uniprot id: A0A8B8URD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MON1/SAND family.
messages: Prevacuolar compartment membrane
messages: Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.
messages: Vacuole membrane
messages: multivesicular body membrane

27291:SPAR P03330
gene id: 27291:SPAR_P03330
uniprot id: A0A8B8UM39
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

27291:SPAR D01650
gene id: 27291:SPAR_D01650
uniprot id: A0A8B8UN57
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR E01770
gene id: 27291:SPAR_E01770
uniprot id: A0A8B8UQ62
names: Similarity
messages: Belongs to the peptidase C19 family.

27291:SPAR N02910
gene id: 27291:SPAR_N02910
uniprot id: A0A8B8UYY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.
messages: Cytoplasm

27291:SPAR D06330
gene id: 27291:SPAR_D06330
uniprot id: A0A8B8UPF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endopolyphosphatase PPN1 family.
messages: Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.
messages: Membrane
messages: Vacuole membrane

27291:SPAR C00040
gene id: 27291:SPAR_C00040
uniprot id: A0A8B8UML5
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR D05400
gene id: 27291:SPAR_D05400
uniprot id: A0A8B8UP87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP22 family.
messages: Mitochondrion inner membrane
messages: Translation factor specific for subunit 6 of the mitochondrial ATPase. Required for assembly of the CF(0) component of the ATPase.

27291:SPAR P02330
gene id: 27291:SPAR_P02330
uniprot id: A0A8B8V138
names: Similarity
messages: Belongs to the protein kinase superfamily.

27291:SPAR B01600
gene id: 27291:SPAR_B01600
uniprot id: A0A8B8ULL8
names: Similarity
messages: Belongs to the peptidase C19 family.

27291:SPAR D06820
gene id: 27291:SPAR_D06820
uniprot id: A0A8B8UPM1
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.

27291:SPAR D03010
gene id: 27291:SPAR_D03010
uniprot id: A0A8B8UNJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP23 family.
messages: Golgi apparatus membrane
messages: Golgi membrane protein involved in vesicular trafficking.
messages: Membrane

27291:SPAR D06150
gene id: 27291:SPAR_D06150
uniprot id: A0A8B8UPE8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M16 family. PreP subfamily.
messages: Mitochondrion intermembrane space
messages: Mitochondrion matrix
messages: Monomer and homodimer; homodimerization is induced by binding of the substrate.

27291:SPAR K02240
gene id: 27291:SPAR_K02240
uniprot id: A0A8B8UV41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR D06610
gene id: 27291:SPAR_D06610
uniprot id: A0A8B8UPK9
names: Similarity
messages: Belongs to the glycosyltransferase 15 family.

27291:SPAR D06110
gene id: 27291:SPAR_D06110
uniprot id: A0A8B8UPF9
names: Similarity
messages: Belongs to the sorting nexin family.

27291:SPAR K01590
gene id: 27291:SPAR_K01590
uniprot id: A0A8B8UUX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex ASK1 family.
messages: Nucleus
messages: kinetochore
messages: spindle

27291:SPAR P03720
gene id: 27291:SPAR_P03720
uniprot id: A0A8B8V1H6
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR E00780
gene id: 27291:SPAR_E00780
uniprot id: A0A8B8UQ79
names: Similarity
messages: Belongs to the SEC3 family.

27291:SPAR G01310
gene id: 27291:SPAR_G01310
uniprot id: A0A8B8UR84
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

27291:SPAR N02250
gene id: 27291:SPAR_N02250
uniprot id: A0A8B8UYL7
names: Similarity
messages: Belongs to the XPG/RAD2 endonuclease family.

27291:SPAR L03970
gene id: 27291:SPAR_L03970
uniprot id: A0A8B8UWN8
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

27291:SPAR O01900
gene id: 27291:SPAR_O01900
uniprot id: A0A8B8UZJ9
names: Function
names: Similarity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.

27291:SPAR G04610
gene id: 27291:SPAR_G04610
uniprot id: A0A8B8US64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. GCN5 subfamily.
messages: Nucleus

27291:SPAR D03000
gene id: 27291:SPAR_D03000
uniprot id: A0A8B8UNJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RRP8 family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.
messages: nucleolus

27291:SPAR A00600
gene id: 27291:SPAR_A00600
uniprot id: A0A8B8UL19
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.

27291:SPAR B01830
gene id: 27291:SPAR_B01830
uniprot id: A0A8B8UM07
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR I00760
gene id: 27291:SPAR_I00760
uniprot id: A0A8B8UTD4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrion-specific ribosomal protein mS23 family.
messages: Component of the mitochondrial small ribosomal subunit.
messages: Mitochondrion

27291:SPAR B03310
gene id: 27291:SPAR_B03310
uniprot id: A0A8B8UM24
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR B00660
gene id: 27291:SPAR_B00660
uniprot id: A0A8B8ULB6
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

27291:SPAR G04200
gene id: 27291:SPAR_G04200
uniprot id: A0A8B8URY4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF beta-subunit/FixA family.
messages: Binds 1 AMP per subunit.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

27291:SPAR M03480
gene id: 27291:SPAR_M03480
uniprot id: A0A8B8UXP2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS11 family.
messages: Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.
messages: Vacuole membrane

27291:SPAR J01310
gene id: 27291:SPAR_J01310
uniprot id: A0A8B8UU17
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS2/PSF2 family.
messages: Component of the GINS complex.
messages: Nucleus

27291:SPAR N01370
gene id: 27291:SPAR_N01370
uniprot id: A0A8B8UYH2
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

27291:SPAR I00440
gene id: 27291:SPAR_I00440
uniprot id: A0A8B8UT64
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR N02510
gene id: 27291:SPAR_N02510
uniprot id: A0A8B8UYU1
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

27291:SPAR L01750
gene id: 27291:SPAR_L01750
uniprot id: A0A8B8UW14
names: Similarity
messages: Belongs to the cullin family.

27291:SPAR P01820
gene id: 27291:SPAR_P01820
uniprot id: A0A8B8V0Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Membrane

27291:SPAR O02970
gene id: 27291:SPAR_O02970
uniprot id: A0A8B8V006
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

27291:SPAR O00370
gene id: 27291:SPAR_O00370
uniprot id: A0A8B8UZ96
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR N00330
gene id: 27291:SPAR_N00330
uniprot id: A0A8B8UY16
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

27291:SPAR O02370
gene id: 27291:SPAR_O02370
uniprot id: A0A8B8UZU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

27291:SPAR I00890
gene id: 27291:SPAR_I00890
uniprot id: A0A8B8UTA4
names: Function
names: Similarity
messages: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the proteasome subunit S1 family.

27291:SPAR D00520
gene id: 27291:SPAR_D00520
uniprot id: A0A8B8UMS4
names: Similarity
messages: Belongs to the UPP synthase family.

27291:SPAR E01290
gene id: 27291:SPAR_E01290
uniprot id: A0A8B8UQ28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

27291:SPAR L03420
gene id: 27291:SPAR_L03420
uniprot id: A0A8B8UWI5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

27291:SPAR D02390
gene id: 27291:SPAR_D02390
uniprot id: A0A8B8UND2
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

27291:SPAR K00370
gene id: 27291:SPAR_K00370
uniprot id: A0A8B8UUK5
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

27291:SPAR K00310
gene id: 27291:SPAR_K00310
uniprot id: A0A8B8UUQ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the calcineurin regulatory subunit family.
messages: Composed of a catalytic subunit (A) and a regulatory subunit (B).
messages: Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

27291:SPAR G01440
gene id: 27291:SPAR_G01440
uniprot id: A0A8B8URF7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HDDC2 family.
messages: Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).
messages: Homodimer.

27291:SPAR I00830
gene id: 27291:SPAR_I00830
uniprot id: A0A8B8UTB1
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR N03550
gene id: 27291:SPAR_N03550
uniprot id: A0A8B8UYZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
messages: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
messages: nucleolus

27291:SPAR M01200
gene id: 27291:SPAR_M01200
uniprot id: A0A8B8UX15
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

27291:SPAR P00190
gene id: 27291:SPAR_P00190
uniprot id: A0A8B8V0M4
names: Similarity
messages: Belongs to the adaptor complexes medium subunit family.

27291:SPAR O04830
gene id: 27291:SPAR_O04830
uniprot id: A0A8B8V0E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferric reductase (FRE) family.
messages: Cell membrane
messages: Membrane

27291:SPAR F00930
gene id: 27291:SPAR_F00930
uniprot id: A0A8B8UQP3
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

27291:SPAR G03080
gene id: 27291:SPAR_G03080
uniprot id: A0A8B8URL6
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.

27291:SPAR G03860
gene id: 27291:SPAR_G03860
uniprot id: A0A8B8URZ2
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

27291:SPAR D06950
gene id: 27291:SPAR_D06950
uniprot id: A0A8B8UPN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPS2 family.
messages: Cell membrane
messages: Membrane

27291:SPAR O02410
gene id: 27291:SPAR_O02410
uniprot id: A0A8B8UZR0
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.

27291:SPAR L00200
gene id: 27291:SPAR_L00200
uniprot id: A0A8B8UVK4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.
messages: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

27291:SPAR P04370
gene id: 27291:SPAR_P04370
uniprot id: A0A8B8V1N8
names: Similarity
messages: Belongs to the MAL13 family.

27291:SPAR D06130
gene id: 27291:SPAR_D06130
uniprot id: A0A8B8UPD7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the kynurenine formamidase family.
messages: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.
messages: Homodimer.
messages: The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.

27291:SPAR K00870
gene id: 27291:SPAR_K00870
uniprot id: A0A8B8UUQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: actin patch

27291:SPAR P01200
gene id: 27291:SPAR_P01200
uniprot id: A0A8B8V0T1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.
messages: Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5.
messages: Nucleus

27291:SPAR J02120
gene id: 27291:SPAR_J02120
uniprot id: A0A8B8UU50
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
messages: Cytoplasm

27291:SPAR J02090
gene id: 27291:SPAR_J02090
uniprot id: A0A8B8UU49
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

27291:SPAR H01430
gene id: 27291:SPAR_H01430
uniprot id: A0A8B8USU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BIG1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR B01630
gene id: 27291:SPAR_B01630
uniprot id: A0A8B8ULZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC2 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Component of the origin recognition complex (ORC).
messages: Nucleus

27291:SPAR L02260
gene id: 27291:SPAR_L02260
uniprot id: A0A8B8UW05
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit J family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

27291:SPAR D00610
gene id: 27291:SPAR_D00610
uniprot id: A0A8B8UMV3
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.

27291:SPAR A00250
gene id: 27291:SPAR_A00250
uniprot id: A0A8B8UKX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR O03910
gene id: 27291:SPAR_O03910
uniprot id: A0A8B8V049
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.

27291:SPAR P02060
gene id: 27291:SPAR_P02060
uniprot id: A0A8B8V150
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mitochondrion inner membrane

27291:SPAR G04410
gene id: 27291:SPAR_G04410
uniprot id: A0A8B8US46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Mitochondrion inner membrane

27291:SPAR C01380
gene id: 27291:SPAR_C01380
uniprot id: A0A8B8UML0
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

27291:SPAR P00410
gene id: 27291:SPAR_P00410
uniprot id: A0A8B8V0N9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.
messages: Nucleus

27291:SPAR M04260
gene id: 27291:SPAR_M04260
uniprot id: A0A8B8UY15
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily.

27291:SPAR B03120
gene id: 27291:SPAR_B03120
uniprot id: A0A8B8ULY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDS23 family.
messages: Cytoplasm
messages: Involved in DNA replication and cell separation.

27291:SPAR D00450
gene id: 27291:SPAR_D00450
uniprot id: A0A8B8UMT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Forms a complex with TRM82.
messages: Methyltransferase that catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA, a modification required to maintain stability of tRNAs; its absence resulting in tRNA decay. Both the D-stem and T-stem structures of tRNAs are required for efficient methyltransferase activity.
messages: Nucleus

27291:SPAR O04510
gene id: 27291:SPAR_O04510
uniprot id: A0A8B8V0B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

27291:SPAR E00840
gene id: 27291:SPAR_E00840
uniprot id: A0A8B8UPY0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
messages: Mitochondrion inner membrane

27291:SPAR F00380
gene id: 27291:SPAR_F00380
uniprot id: A0A8B8UQI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.
messages: Membrane

27291:SPAR L01300
gene id: 27291:SPAR_L01300
uniprot id: A0A8B8UVW6
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

27291:SPAR D05830
gene id: 27291:SPAR_D05830
uniprot id: A0A8B8UPM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHE9 family.
messages: Homooligomer.
messages: Mitochondrion inner membrane
messages: Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed.

27291:SPAR P03860
gene id: 27291:SPAR_P03860
uniprot id: A0A8B8V1M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

27291:SPAR E01970
gene id: 27291:SPAR_E01970
uniprot id: A0A8B8UQ82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Vacuole membrane

27291:SPAR A00790
gene id: 27291:SPAR_A00790
uniprot id: A0A8B8UL29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OSBP family.
messages: Membrane

27291:SPAR I01350
gene id: 27291:SPAR_I01350
uniprot id: A0A8B8UTB2
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

27291:SPAR K03070
gene id: 27291:SPAR_K03070
uniprot id: A0A8B8UVC3
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR N01430
gene id: 27291:SPAR_N01430
uniprot id: A0A8B8UYC9
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

27291:SPAR H01530
gene id: 27291:SPAR_H01530
uniprot id: A0A8B8USV2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.

27291:SPAR M04210
gene id: 27291:SPAR_M04210
uniprot id: A0A8B8UY10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 17 family.
messages: cell wall

27291:SPAR L01150
gene id: 27291:SPAR_L01150
uniprot id: A0A8B8UVV2
names: Similarity
messages: Belongs to the oligoribonuclease family.

27291:SPAR M03550
gene id: 27291:SPAR_M03550
uniprot id: A0A8B8UXQ4
names: Similarity
messages: Belongs to the glycosyl hydrolase 76 family.

27291:SPAR O04780
gene id: 27291:SPAR_O04780
uniprot id: A0A8B8V0D9
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR P02540
gene id: 27291:SPAR_P02540
uniprot id: A0A8B8V1A6
names: Similarity
messages: Belongs to the NEMF family.

27291:SPAR G00160
gene id: 27291:SPAR_G00160
uniprot id: A0A8B8UQX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

27291:SPAR E01670
gene id: 27291:SPAR_E01670
uniprot id: A0A8B8UQ53
names: Similarity
messages: Belongs to the PP2C family.

27291:SPAR M00630
gene id: 27291:SPAR_M00630
uniprot id: A0A8B8UWV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Nucleus

27291:SPAR N03380
gene id: 27291:SPAR_N03380
uniprot id: A0A8B8UZ23
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Component of the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

27291:SPAR D01420
gene id: 27291:SPAR_D01420
uniprot id: A0A8B8UN15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

27291:SPAR L01250
gene id: 27291:SPAR_L01250
uniprot id: A0A8B8UVW3
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

27291:SPAR E00890
gene id: 27291:SPAR_E00890
uniprot id: A0A8B8UPY7
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

27291:SPAR M03130
gene id: 27291:SPAR_M03130
uniprot id: A0A8B8UXK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTI1 family.
messages: Golgi apparatus membrane
messages: Membrane

27291:SPAR I00450
gene id: 27291:SPAR_I00450
uniprot id: A0A8B8UT17
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

27291:SPAR D06620
gene id: 27291:SPAR_D06620
uniprot id: A0A8B8UPJ9
names: Similarity
messages: Belongs to the VPS52 family.

27291:SPAR G00990
gene id: 27291:SPAR_G00990
uniprot id: A0A8B8URB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 5 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

27291:SPAR O02120
gene id: 27291:SPAR_O02120
uniprot id: A0A8B8UZS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

27291:SPAR M02150
gene id: 27291:SPAR_M02150
uniprot id: A0A8B8UXB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP25 family.
messages: Mitochondrial mRNA stabilization factor.
messages: Mitochondrion inner membrane
messages: mRNA stabilization factor specific for the 0.95 kb OLI1 mRNA. Also involved in OLI1 ring formation.

27291:SPAR D00060
gene id: 27291:SPAR_D00060
uniprot id: A0A8B8UMP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NMT1/THI5 family.
messages: Homodimer.
messages: Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.

27291:SPAR K00170
gene id: 27291:SPAR_K00170
uniprot id: A0A8B8UUI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC3 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).

27291:SPAR E00130
gene id: 27291:SPAR_E00130
uniprot id: A0A8B8UQ14
names: Similarity
messages: Belongs to the NPR2 family.

27291:SPAR G04060
gene id: 27291:SPAR_G04060
uniprot id: A0A8B8US13
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

27291:SPAR M01360
gene id: 27291:SPAR_M01360
uniprot id: A0A8B8UX79
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CLU family.
messages: Cytoplasm
messages: May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.

27291:SPAR N00620
gene id: 27291:SPAR_N00620
uniprot id: A0A8B8UY96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

27291:SPAR O00960
gene id: 27291:SPAR_O00960
uniprot id: A0A8B8UZB2
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

27291:SPAR J01690
gene id: 27291:SPAR_J01690
uniprot id: A0A8B8UU15
names: Similarity
messages: Belongs to the MAD2 family.

27291:SPAR B01710
gene id: 27291:SPAR_B01710
uniprot id: A0A8B8ULL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

27291:SPAR K00330
gene id: 27291:SPAR_K00330
uniprot id: A0A8B8UUQ2
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR D02850
gene id: 27291:SPAR_D02850
uniprot id: A0A8B8UNH7
names: Similarity
messages: Belongs to the peptidase C19 family.

27291:SPAR B01560
gene id: 27291:SPAR_B01560
uniprot id: A0A8B8ULK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal/bacterial/fungal opsin family.
messages: Membrane

27291:SPAR D01210
gene id: 27291:SPAR_D01210
uniprot id: A0A8B8UN14
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup84/Nup107 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: Part of the nuclear pore complex (NPC).
messages: nuclear pore complex

27291:SPAR L03490
gene id: 27291:SPAR_L03490
uniprot id: A0A8B8UWG9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS25 family.

27291:SPAR C00670
gene id: 27291:SPAR_C00670
uniprot id: A0A8B8UMF7
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR G01860
gene id: 27291:SPAR_G01860
uniprot id: A0A8B8URD8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Expected to bind 2 Fe(2+) ions per subunit.
messages: Membrane
messages: Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.

27291:SPAR L04410
gene id: 27291:SPAR_L04410
uniprot id: A0A8B8UWM0
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

27291:A560 mgp03
gene id: 27291:A560_mgp03
uniprot id: P61828
uniprot id: Q71U90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 18 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i, j and k.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

27291:SPAR J02660
gene id: 27291:SPAR_J02660
uniprot id: A0A8B8UUF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC2 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.

27291:SPAR P03090
gene id: 27291:SPAR_P03090
uniprot id: A0A8B8V1F9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG11 family.
messages: Homodimer.
messages: Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.
messages: Membrane
messages: Preautophagosomal structure membrane
messages: Vacuole membrane

27291:SPAR N01120
gene id: 27291:SPAR_N01120
uniprot id: A0A8B8UYE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRG9 family.
messages: Mitochondrion
messages: Required for respiratory activity and maintenance and expression of the mitochondrial genome.

27291:SPAR P01540
gene id: 27291:SPAR_P01540
uniprot id: A0A8B8V105
names: Similarity
messages: Belongs to the IPP isomerase type 1 family.

27291:SPAR M02250
gene id: 27291:SPAR_M02250
uniprot id: A0A8B8UXC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: actin patch

27291:SPAR I01020
gene id: 27291:SPAR_I01020
uniprot id: A0A8B8UT84
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

27291:SPAR O02290
gene id: 27291:SPAR_O02290
uniprot id: A0A8B8UZT2
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

27291:SPAR O04180
gene id: 27291:SPAR_O04180
uniprot id: A0A8B8V079
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR N02440
gene id: 27291:SPAR_N02440
uniprot id: A0A8B8UYM9
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR J01880
gene id: 27291:SPAR_J01880
uniprot id: A0A8B8UU62
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST1 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

27291:SPAR P02380
gene id: 27291:SPAR_P02380
uniprot id: A0A8B8V142
names: Similarity
messages: Belongs to the protein kinase superfamily.

27291:SPAR D00290
gene id: 27291:SPAR_D00290
uniprot id: A0A8B8UMS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex.
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR B02160
gene id: 27291:SPAR_B02160
uniprot id: A0A8B8ULR2
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.

27291:SPAR D01290
gene id: 27291:SPAR_D01290
uniprot id: A0A8B8UN22
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

27291:SPAR L00430
gene id: 27291:SPAR_L00430
uniprot id: A0A8B8UVG8
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR L03100
gene id: 27291:SPAR_L03100
uniprot id: A0A8B8UW90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. LepA subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Mitochondrion inner membrane
messages: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.

27291:SPAR D06900
gene id: 27291:SPAR_D06900
uniprot id: A0A8B8UPM6
names: Similarity
messages: Belongs to the hexokinase family.

27291:SPAR N03080
gene id: 27291:SPAR_N03080
uniprot id: A0A8B8UYZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS27 family.
messages: Component of the ESCRT-0 complex composed of HSE1 and VPS27.
messages: Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.
messages: Endosome membrane
messages: Membrane

27291:SPAR D06170
gene id: 27291:SPAR_D06170
uniprot id: A0A8B8UPF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGS family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR D04990
gene id: 27291:SPAR_D04990
uniprot id: A0A8B8UP36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

27291:SPAR M03090
gene id: 27291:SPAR_M03090
uniprot id: A0A8B8UXQ8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

27291:SPAR D00440
gene id: 27291:SPAR_D00440
uniprot id: A0A8B8UMU1
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.

27291:SPAR M03180
gene id: 27291:SPAR_M03180
uniprot id: A0A8B8UXL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG2 family.
messages: Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols.
messages: Endoplasmic reticulum membrane

27291:SPAR D03790
gene id: 27291:SPAR_D03790
uniprot id: A0A8B8UNS0
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

27291:SPAR M04010
gene id: 27291:SPAR_M04010
uniprot id: A0A8B8UXZ0
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

27291:SPAR E00640
gene id: 27291:SPAR_E00640
uniprot id: A0A8B8UPW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR L01020
gene id: 27291:SPAR_L01020
uniprot id: A0A8B8UVS6
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR H01640
gene id: 27291:SPAR_H01640
uniprot id: A0A8B8USQ0
names: Similarity
messages: Belongs to the MIP18 family.

27291:SPAR K00700
gene id: 27291:SPAR_K00700
uniprot id: A0A8B8UUP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

27291:SPAR P03140
gene id: 27291:SPAR_P03140
uniprot id: A0A8B8V1G4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFB4 family.
messages: Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
messages: Nucleus

27291:SPAR M01930
gene id: 27291:SPAR_M01930
uniprot id: A0A8B8UX82
names: Similarity
messages: Belongs to the PDCD5 family.

27291:SPAR J01560
gene id: 27291:SPAR_J01560
uniprot id: A0A8B8UU45
names: Function
names: Similarity
messages: Belongs to the LplA family.
messages: Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.

27291:SPAR B02150
gene id: 27291:SPAR_B02150
uniprot id: A0A8B8ULR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

27291:SPAR K01260
gene id: 27291:SPAR_K01260
uniprot id: A0A8B8UV00
names: Similarity
messages: Belongs to the sulfiredoxin family.

27291:SPAR B02460
gene id: 27291:SPAR_B02460
uniprot id: A0A8B8ULU1
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR D06690
gene id: 27291:SPAR_D06690
uniprot id: A0A8B8UPV9
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR K01510
gene id: 27291:SPAR_K01510
uniprot id: A0A8B8UV27
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

27291:SPAR N02490
gene id: 27291:SPAR_N02490
uniprot id: A0A8B8UYN4
names: Similarity
messages: Belongs to the actin family.

27291:SPAR C01010
gene id: 27291:SPAR_C01010
uniprot id: A0A8B8UMJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.
messages: Cytoplasm
messages: Nucleus

27291:SPAR H01150
gene id: 27291:SPAR_H01150
uniprot id: A0A8B8USN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OSBP family.
messages: Membrane

27291:SPAR C01170
gene id: 27291:SPAR_C01170
uniprot id: A0A8B8UMK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL49 family.
messages: Mitochondrion

27291:SPAR L01440
gene id: 27291:SPAR_L01440
uniprot id: A0A8B8UVS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GEP5 family.
messages: Essential for respiratory growth and required for maintenance of mtDNA. Required for cell survival in the absence of prohibitins.
messages: Mitochondrion

27291:SPAR D03200
gene id: 27291:SPAR_D03200
uniprot id: A0A8B8UNL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

27291:SPAR D06810
gene id: 27291:SPAR_D06810
uniprot id: A0A8B8UPN0
names: Similarity
messages: Belongs to the multicopper oxidase family.

27291:SPAR L01600
gene id: 27291:SPAR_L01600
uniprot id: A0A8B8UW01
names: Similarity
messages: Belongs to the REXO1/REXO3 family.

27291:SPAR I00860
gene id: 27291:SPAR_I00860
uniprot id: A0A8B8UTE4
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

27291:SPAR L01670
gene id: 27291:SPAR_L01670
uniprot id: A0A8B8UVZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBP/SF1 family.
messages: Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
messages: Nucleus

27291:SPAR J03230
gene id: 27291:SPAR_J03230
uniprot id: A0A8B8UUK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

27291:SPAR L02530
gene id: 27291:SPAR_L02530
uniprot id: A0A8B8UW32
names: Subcellular Location Annotation
messages: nucleolus

27291:SPAR D00530
gene id: 27291:SPAR_D00530
uniprot id: A0A8B8UN54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

27291:SPAR O00250
gene id: 27291:SPAR_O00250
uniprot id: A0A8B8UZ34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Membrane
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.

27291:SPAR K02060
gene id: 27291:SPAR_K02060
uniprot id: A0A8B8UV80
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR N01840
gene id: 27291:SPAR_N01840
uniprot id: A0A8B8UYG8
names: Similarity
messages: Belongs to the Tom22 family.

27291:SPAR F01090
gene id: 27291:SPAR_F01090
uniprot id: A0A8B8UQU6
names: Similarity
messages: Belongs to the RMD1/sif2 family.

27291:SPAR D02820
gene id: 27291:SPAR_D02820
uniprot id: A0A8B8UNF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPAP2 family.
messages: Nucleus
messages: Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.

27291:SPAR N00530
gene id: 27291:SPAR_N00530
uniprot id: A0A8B8UY39
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRM1 family.
messages: Cell membrane
messages: Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

27291:SPAR P03850
gene id: 27291:SPAR_P03850
uniprot id: A0A8B8V1J9
names: Similarity
messages: Belongs to the taffazin family.

27291:SPAR P01800
gene id: 27291:SPAR_P01800
uniprot id: A0A8B8V0Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MEF2 family.
messages: Nucleus

27291:SPAR P03500
gene id: 27291:SPAR_P03500
uniprot id: A0A8B8V1G6
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.

27291:SPAR D01990
gene id: 27291:SPAR_D01990
uniprot id: A0A8B8UN94
names: Similarity
messages: Belongs to the actin family.

27291:SPAR D01060
gene id: 27291:SPAR_D01060
uniprot id: A0A8B8UMZ7
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.

27291:SPAR M00690
gene id: 27291:SPAR_M00690
uniprot id: A0A8B8UX23
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).
messages: Cytoplasm

27291:SPAR J00860
gene id: 27291:SPAR_J00860
uniprot id: A0A8B8UTX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.
messages: Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.
messages: Nucleus

27291:SPAR D05990
gene id: 27291:SPAR_D05990
uniprot id: A0A8B8UPD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.
messages: Membrane

27291:SPAR J01330
gene id: 27291:SPAR_J01330
uniprot id: A0A8B8UU09
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

27291:SPAR N00980
gene id: 27291:SPAR_N00980
uniprot id: A0A8B8UY86
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GST superfamily.
messages: Homodimer.
messages: Plays an important role in the cellular response to the nitrogen source.

27291:SPAR G01580
gene id: 27291:SPAR_G01580
uniprot id: A0A8B8UR66
names: Similarity
messages: Belongs to the MAD1 family.

27291:SPAR M01170
gene id: 27291:SPAR_M01170
uniprot id: A0A8B8UX05
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT5 family.
messages: Nucleus
messages: The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.

27291:SPAR O04020
gene id: 27291:SPAR_O04020
uniprot id: A0A8B8V0B4
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR F00590
gene id: 27291:SPAR_F00590
uniprot id: A0A8B8UQP2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

27291:A560 mgp01
gene id: 27291:A560_mgp01
uniprot id: I1Z694
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane

27291:SPAR F00130
gene id: 27291:SPAR_F00130
uniprot id: A0A8B8UQG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the flocculin family.
messages: Membrane

27291:SPAR G04680
gene id: 27291:SPAR_G04680
uniprot id: A0A8B8US26
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR D02710
gene id: 27291:SPAR_D02710
uniprot id: A0A8B8UNG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPS2 family.
messages: Cell membrane
messages: Membrane

27291:SPAR M02000
gene id: 27291:SPAR_M02000
uniprot id: A0A8B8UX97
names: Similarity
messages: Belongs to the ISF1/MBR1 family.

27291:SPAR M03430
gene id: 27291:SPAR_M03430
uniprot id: A0A8B8UXN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF7 family.
messages: Nucleus

27291:SPAR O03770
gene id: 27291:SPAR_O03770
uniprot id: A0A8B8V090
names: Function
names: Similarity
messages: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the peptidase M67A family.

27291:SPAR M02170
gene id: 27291:SPAR_M02170
uniprot id: A0A8B8UXA3
names: Similarity
messages: Belongs to the MUB1/samB family.

27291:SPAR P04190
gene id: 27291:SPAR_P04190
uniprot id: A0A8B8V1V2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

27291:SPAR L01130
gene id: 27291:SPAR_L01130
uniprot id: A0A8B8UVP0
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

27291:SPAR M03390
gene id: 27291:SPAR_M03390
uniprot id: A0A8B8UXT8
names: Similarity
messages: Belongs to the peptidase C19 family.

27291:SPAR N00060
gene id: 27291:SPAR_N00060
uniprot id: A0A8B8UMP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NMT1/THI5 family.
messages: Homodimer.
messages: Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.

27291:SPAR B02680
gene id: 27291:SPAR_B02680
uniprot id: A0A8B8UM86
names: Subcellular Location Annotation
messages: Membrane
messages: Peroxisome membrane

27291:SPAR M00670
gene id: 27291:SPAR_M00670
uniprot id: A0A8B8UWV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC1 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Nucleus
messages: ORC is composed of six subunits.

27291:SPAR M01500
gene id: 27291:SPAR_M01500
uniprot id: A0A8B8UX45
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pex2/pex10/pex12 family.
messages: Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.
messages: Membrane
messages: Peroxisome membrane

27291:SPAR P02050
gene id: 27291:SPAR_P02050
uniprot id: A0A8B8V118
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

27291:SPAR A00825
gene id: 27291:SPAR_A00825
uniprot id: A0A8B8USY6
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

27291:SPAR D03830
gene id: 27291:SPAR_D03830
uniprot id: A0A8B8UP37
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

27291:SPAR B02520
gene id: 27291:SPAR_B02520
uniprot id: A0A8B8ULS2
names: Function
names: Similarity
messages: Belongs to the HTP reductase family.
messages: Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.

27291:SPAR D06360
gene id: 27291:SPAR_D06360
uniprot id: A0A8B8UPI2
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

27291:SPAR O02930
gene id: 27291:SPAR_O02930
uniprot id: A0A8B8UZV9
names: Similarity
messages: Belongs to the GET4 family.

27291:SPAR M01260
gene id: 27291:SPAR_M01260
uniprot id: A0A8B8UX69
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

27291:SPAR B00830
gene id: 27291:SPAR_B00830
uniprot id: A0A8B8ULR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Nucleus

27291:SPAR O03260
gene id: 27291:SPAR_O03260
uniprot id: A0A8B8UZY9
names: Similarity
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.

27291:SPAR G03410
gene id: 27291:SPAR_G03410
uniprot id: A0A8B8URU6
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.

27291:SPAR L00170
gene id: 27291:SPAR_L00170
uniprot id: A0A8B8UVJ2
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the ribosome.

27291:SPAR N00240
gene id: 27291:SPAR_N00240
uniprot id: A0A8B8UY14
names: Similarity
messages: Belongs to the replication factor A protein 2 family.

27291:SPAR A00300
gene id: 27291:SPAR_A00300
uniprot id: A0A8B8UKY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mis12 family.
messages: kinetochore

27291:SPAR A00550
gene id: 27291:SPAR_A00550
uniprot id: A0A8B8UL15
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MDM10 family.
messages: Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex, which consists of SAM35, SAM37 and SAM50, to form a SAM(holo) complex.
messages: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.
messages: Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.
messages: Mitochondrion outer membrane

27291:SPAR I00270
gene id: 27291:SPAR_I00270
uniprot id: A0A8B8UT16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.

27291:SPAR D00950
gene id: 27291:SPAR_D00950
uniprot id: A0A8B8UMY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.

27291:SPAR L01700
gene id: 27291:SPAR_L01700
uniprot id: A0A8B8UW09
names: Similarity
messages: Belongs to the VPS37 family.

27291:SPAR J01180
gene id: 27291:SPAR_J01180
uniprot id: A0A8B8UTY9
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily.

27291:SPAR B03740
gene id: 27291:SPAR_B03740
uniprot id: A0A8B8UM83
names: Similarity
messages: Belongs to the PAF1 family.

27291:SPAR E02120
gene id: 27291:SPAR_E02120
uniprot id: A0A8B8UQ98
names: Similarity
messages: Belongs to the Rab GDI family.

27291:SPAR H01740
gene id: 27291:SPAR_H01740
uniprot id: A0A8B8USR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR F00460
gene id: 27291:SPAR_F00460
uniprot id: A0A8B8UQI6
names: Similarity
messages: Belongs to the acetyltransferase family. GNA1 subfamily.

27291:SPAR D00050
gene id: 27291:SPAR_D00050
uniprot id: A0A8B8UMN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR I01080
gene id: 27291:SPAR_I01080
uniprot id: A0A8B8UTD5
names: Similarity
messages: Belongs to the RutC family.

27291:SPAR L03880
gene id: 27291:SPAR_L03880
uniprot id: A0A8B8UWH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecY/SEC61-alpha family.
messages: Membrane

27291:SPAR N02380
gene id: 27291:SPAR_N02380
uniprot id: A0A8B8UYS5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. Eukaryotic subfamily.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

27291:SPAR A00830
gene id: 27291:SPAR_A00830
uniprot id: A0A8B8UT26
names: Similarity
messages: Belongs to the PhyH family.

27291:SPAR I00950
gene id: 27291:SPAR_I00950
uniprot id: A0A8B8UT72
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

27291:SPAR M00080
gene id: 27291:SPAR_M00080
uniprot id: A0A8B8UWQ1
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

27291:SPAR N01930
gene id: 27291:SPAR_N01930
uniprot id: A0A8B8UYM7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

27291:SPAR O01420
gene id: 27291:SPAR_O01420
uniprot id: A0A8B8UZK5
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

27291:SPAR P01780
gene id: 27291:SPAR_P01780
uniprot id: A0A8B8V0Y0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
messages: Membrane

27291:SPAR B00670
gene id: 27291:SPAR_B00670
uniprot id: A0A8B8UL73
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

27291:SPAR F00080
gene id: 27291:SPAR_F00080
uniprot id: A0A8B8UQG3
names: Similarity
messages: Belongs to the MAL13 family.

27291:SPAR M00300
gene id: 27291:SPAR_M00300
uniprot id: A0A8B8UWS5
names: Similarity
messages: Belongs to the sorting nexin family.

27291:SPAR M03610
gene id: 27291:SPAR_M03610
uniprot id: A0A8B8UXV0
names: Similarity
messages: Belongs to the SUN family.

27291:SPAR O02850
gene id: 27291:SPAR_O02850
uniprot id: A0A8B8UZU5
names: Similarity
messages: Belongs to the PIAS family.

27291:SPAR O00060
gene id: 27291:SPAR_O00060
uniprot id: A0A8B8UZ17
names: Similarity
messages: Belongs to the peptidase M20A family.

27291:SPAR N02410
gene id: 27291:SPAR_N02410
uniprot id: A0A8B8UYT1
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR O00570
gene id: 27291:SPAR_O00570
uniprot id: A0A8B8UZC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with COQ3.
messages: Mitochondrion inner membrane
messages: O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

27291:SPAR K02690
gene id: 27291:SPAR_K02690
uniprot id: A0A8B8UV85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PAM17 family.
messages: Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Component of the PAM complex.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR C00560
gene id: 27291:SPAR_C00560
uniprot id: A0A8B8UMF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-II family.
messages: Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.
messages: Mitochondrion

27291:SPAR P01510
gene id: 27291:SPAR_P01510
uniprot id: A0A8B8V0Z6
names: Similarity
messages: Belongs to the beclin family.

27291:SPAR D00740
gene id: 27291:SPAR_D00740
uniprot id: A0A8B8UMX1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

27291:SPAR B03810
gene id: 27291:SPAR_B03810
uniprot id: A0A8B8UM79
names: Similarity
messages: Belongs to the peptidase M28 family. M28A subfamily.

27291:SPAR O01390
gene id: 27291:SPAR_O01390
uniprot id: A0A8B8UZJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MDM12 family.
messages: Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking. Interacts with PUF3.
messages: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

27291:SPAR L02270
gene id: 27291:SPAR_L02270
uniprot id: A0A8B8UW68
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

27291:SPAR O02800
gene id: 27291:SPAR_O02800
uniprot id: A0A8B8UZT9
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

27291:SPAR C00280
gene id: 27291:SPAR_C00280
uniprot id: A0A8B8UM92
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG22 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.
messages: Vacuole membrane

27291:SPAR N00190
gene id: 27291:SPAR_N00190
uniprot id: A0A8B8UY09
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Required for 3'-end cleavage and polyadenylation of pre-mRNAs.

27291:SPAR G00650
gene id: 27291:SPAR_G00650
uniprot id: A0A8B8UQY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR G00820
gene id: 27291:SPAR_G00820
uniprot id: A0A8B8UR29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
messages: nucleolus

27291:SPAR M00700
gene id: 27291:SPAR_M00700
uniprot id: A0A8B8UWW6
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR O01540
gene id: 27291:SPAR_O01540
uniprot id: A0A8B8UZK8
names: Similarity
messages: Belongs to the SGT family.

27291:SPAR H02050
gene id: 27291:SPAR_H02050
uniprot id: A0A8B8USU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Chromosome
messages: Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
messages: Nucleus

27291:SPAR D04210
gene id: 27291:SPAR_D04210
uniprot id: A0A8B8UNW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVF1 family.
messages: Cytoplasm

27291:SPAR O00310
gene id: 27291:SPAR_O00310
uniprot id: A0A8B8UZ43
names: Function
names: Similarity
messages: Belongs to the methyltransferase TRM13 family.
messages: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

27291:SPAR P01180
gene id: 27291:SPAR_P01180
uniprot id: A0A8B8V0S0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

27291:SPAR O04750
gene id: 27291:SPAR_O04750
uniprot id: A0A8B8V0D8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

27291:SPAR H00190
gene id: 27291:SPAR_H00190
uniprot id: A0A8B8USA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPR3 family.
messages: Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.
messages: Vacuole membrane

27291:SPAR K02610
gene id: 27291:SPAR_K02610
uniprot id: A0A8B8UVD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the small ribosomal subunit.
messages: Cytoplasm
messages: Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability.

27291:SPAR G00740
gene id: 27291:SPAR_G00740
uniprot id: A0A8B8UR90
names: Subcellular Location Annotation
messages: Membrane
messages: Preautophagosomal structure membrane

27291:SPAR J01290
gene id: 27291:SPAR_J01290
uniprot id: A0A8B8UTX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC3 subfamily.
messages: Nucleus

27291:SPAR J02990
gene id: 27291:SPAR_J02990
uniprot id: A0A8B8UUD4
names: Similarity
messages: Belongs to the GcvT family. CAF17 subfamily.

27291:SPAR O01490
gene id: 27291:SPAR_O01490
uniprot id: A0A8B8UZK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR G03170
gene id: 27291:SPAR_G03170
uniprot id: A0A8B8URS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR G01330
gene id: 27291:SPAR_G01330
uniprot id: A0A8B8UR41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

27291:SPAR M03940
gene id: 27291:SPAR_M03940
uniprot id: A0A8B8UXZ1
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR N00880
gene id: 27291:SPAR_N00880
uniprot id: A0A8B8UY74
names: Similarity
messages: Belongs to the NARF family.

27291:SPAR D03780
gene id: 27291:SPAR_D03780
uniprot id: A0A8B8UP33
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

27291:SPAR P02900
gene id: 27291:SPAR_P02900
uniprot id: A0A8B8V1A5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

27291:SPAR I01390
gene id: 27291:SPAR_I01390
uniprot id: A0A8B8UTF1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

27291:SPAR O04630
gene id: 27291:SPAR_O04630
uniprot id: A0A8B8V0C5
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

27291:SPAR O03720
gene id: 27291:SPAR_O03720
uniprot id: A0A8B8V085
names: Similarity
messages: Belongs to the peptidase M28 family. M28B subfamily.

27291:SPAR E01960
gene id: 27291:SPAR_E01960
uniprot id: A0A8B8UQA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SHO1 family.
messages: Bud neck
messages: Cell membrane
messages: Cell projection
messages: Membrane
messages: Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity. Detects changes in external osmolarity and activates PBS2 through the stimulation of STE11 and targets PBS2 to the plasma membrane. PBS2 activation leads to changes in glycerol production that helps to balance the intracellular and external osmotic pressures. Activates also HOG1 in response to heat stress and mediates resistance to oxidative stress. Involved in the regulation of the mating pathway. May be a receptor that feeds into the pseudohyphal growth pathway.

27291:SPAR B01130
gene id: 27291:SPAR_B01130
uniprot id: A0A8B8ULT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

27291:SPAR P01020
gene id: 27291:SPAR_P01020
uniprot id: A0A8B8V0Q5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiA prenyltransferase family.
messages: Converts protoheme IX and farnesyl diphosphate to heme O.
messages: Membrane
messages: Mitochondrion membrane

27291:SPAR C00160
gene id: 27291:SPAR_C00160
uniprot id: A0A8B8UMB1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGX family.
messages: Endoplasmic reticulum membrane
messages: Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.

27291:SPAR K01720
gene id: 27291:SPAR_K01720
uniprot id: A0A8B8UUY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LU7TM family.
messages: Membrane

27291:SPAR F01050
gene id: 27291:SPAR_F01050
uniprot id: A0A8B8UQT6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Binds 2 manganese ions per subunit.

27291:SPAR H01200
gene id: 27291:SPAR_H01200
uniprot id: A0A8B8USN8
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR D01610
gene id: 27291:SPAR_D01610
uniprot id: A0A8B8UN51
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

27291:SPAR B01650
gene id: 27291:SPAR_B01650
uniprot id: A0A8B8ULM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.
messages: Cytoplasm
messages: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.

27291:SPAR P04360
gene id: 27291:SPAR_P04360
uniprot id: A0A8B8V1V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

27291:SPAR B01680
gene id: 27291:SPAR_B01680
uniprot id: A0A8B8ULZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLT11 family.
messages: Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.
messages: Nucleus

27291:SPAR H00520
gene id: 27291:SPAR_H00520
uniprot id: A0A8B8UPI6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL27 family.

27291:SPAR N02200
gene id: 27291:SPAR_N02200
uniprot id: A0A8B8UYL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NST1 family.
messages: Cytoplasm
messages: May act as a negative regulator of salt tolerance.

27291:SPAR J00870
gene id: 27291:SPAR_J00870
uniprot id: A0A8B8UTR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.
messages: Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.
messages: Cytoplasm
messages: P-body

27291:SPAR P03540
gene id: 27291:SPAR_P03540
uniprot id: A0A8B8V1K8
names: Similarity
messages: Belongs to the protein kinase superfamily.

27291:SPAR P00660
gene id: 27291:SPAR_P00660
uniprot id: A0A8B8V0R3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP72 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
messages: Cytoplasm

27291:SPAR P00950
gene id: 27291:SPAR_P00950
uniprot id: A0A8B8V0Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-Z subfamily.
messages: Cytoplasm

27291:SPAR F01120
gene id: 27291:SPAR_F01120
uniprot id: A0A8B8UR12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

27291:SPAR J02310
gene id: 27291:SPAR_J02310
uniprot id: A0A8B8UUC2
names: Similarity
messages: Belongs to the NAD kinase family.

27291:SPAR M04220
gene id: 27291:SPAR_M04220
uniprot id: A0A8B8UXW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 48 family.
messages: Membrane

27291:SPAR B03370
gene id: 27291:SPAR_B03370
uniprot id: A0A8B8UM08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR B03180
gene id: 27291:SPAR_B03180
uniprot id: A0A8B8UME0
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

27291:SPAR J00290
gene id: 27291:SPAR_J00290
uniprot id: A0A8B8UTN2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL39 family.

27291:SPAR N00390
gene id: 27291:SPAR_N00390
uniprot id: A0A8B8UY31
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR N01330
gene id: 27291:SPAR_N01330
uniprot id: A0A8B8UYB9
names: Similarity
messages: Belongs to the importin alpha family.

27291:SPAR H00540
gene id: 27291:SPAR_H00540
uniprot id: A0A8B8USD6
names: Similarity
messages: Belongs to the VPS29 family.

27291:SPAR H02450
gene id: 27291:SPAR_H02450
uniprot id: A0A8B8USX8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

27291:SPAR D05640
gene id: 27291:SPAR_D05640
uniprot id: A0A8B8UP98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR B00330
gene id: 27291:SPAR_B00330
uniprot id: A0A8B8ULK7
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

27291:SPAR I00200
gene id: 27291:SPAR_I00200
uniprot id: A0A8B8USZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM10 family.
messages: Nucleus

27291:SPAR K00520
gene id: 27291:SPAR_K00520
uniprot id: A0A8B8UUM2
names: Subcellular Location Annotation
messages: Mitochondrion

27291:SPAR H01540
gene id: 27291:SPAR_H01540
uniprot id: A0A8B8USP0
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

27291:SPAR K00530
gene id: 27291:SPAR_K00530
uniprot id: A0A8B8UUS7
names: Similarity
messages: Belongs to the protein kinase superfamily.

27291:SPAR J01200
gene id: 27291:SPAR_J01200
uniprot id: A0A8B8UTV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EXO70 family.
messages: Bud
messages: Bud neck
messages: Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst.

27291:SPAR K01130
gene id: 27291:SPAR_K01130
uniprot id: A0A8B8UUY7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP11 family.
messages: Component of the ribosomal small subunit (SSU) processome.
messages: Involved in nucleolar processing of pre-18S ribosomal RNA.
messages: nucleolus

27291:SPAR E01690
gene id: 27291:SPAR_E01690
uniprot id: A0A8B8UQ70
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the vitamin-B12 independent methionine synthase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

27291:SPAR B02300
gene id: 27291:SPAR_B02300
uniprot id: A0A8B8ULT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SHE3 family.
messages: Endoplasmic reticulum membrane
messages: RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell. Required for the delivery of cortical endoplasmic reticulum into the emerging bud.

27291:SPAR G04650
gene id: 27291:SPAR_G04650
uniprot id: A0A8B8US33
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

27291:SPAR L00610
gene id: 27291:SPAR_L00610
uniprot id: A0A8B8UVJ0
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR C01190
gene id: 27291:SPAR_C01190
uniprot id: A0A8B8UMX2
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

27291:SPAR P01080
gene id: 27291:SPAR_P01080
uniprot id: A0A8B8V0R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG29 family.
messages: Preautophagosomal structure

27291:SPAR G04850
gene id: 27291:SPAR_G04850
uniprot id: A0A8B8US55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 17 family.
messages: cell wall

27291:SPAR D05260
gene id: 27291:SPAR_D05260
uniprot id: A0A8B8UP65
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR D00400
gene id: 27291:SPAR_D00400
uniprot id: A0A8B8UMS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Membrane

27291:SPAR D03380
gene id: 27291:SPAR_D03380
uniprot id: A0A8B8UNZ4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

27291:SPAR P01880
gene id: 27291:SPAR_P01880
uniprot id: A0A8B8V0Z3
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

27291:SPAR O02020
gene id: 27291:SPAR_O02020
uniprot id: A0A8B8UZR1
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

27291:SPAR P01240
gene id: 27291:SPAR_P01240
uniprot id: A0A8B8V0X8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATG5 family.
messages: Conjugated with ATG12.
messages: Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.
messages: Membrane
messages: Preautophagosomal structure membrane

27291:SPAR O03440
gene id: 27291:SPAR_O03440
uniprot id: A0A8B8V048
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR M00770
gene id: 27291:SPAR_M00770
uniprot id: A0A8B8UWW5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

27291:SPAR G04620
gene id: 27291:SPAR_G04620
uniprot id: A0A8B8US62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1A family.
messages: Nucleus
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

27291:SPAR F00190
gene id: 27291:SPAR_F00190
uniprot id: A0A8B8UQK4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic PMM family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

27291:SPAR P02690
gene id: 27291:SPAR_P02690
uniprot id: A0A8B8V1C1
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR J00020
gene id: 27291:SPAR_J00020
uniprot id: A0A8B8UTH9
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR P03680
gene id: 27291:SPAR_P03680
uniprot id: A0A8B8V1H3
names: Similarity
messages: Belongs to the cyclin family.

27291:SPAR B03160
gene id: 27291:SPAR_B03160
uniprot id: A0A8B8UM10
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
messages: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

27291:SPAR O03010
gene id: 27291:SPAR_O03010
uniprot id: A0A8B8UZW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 4 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

27291:SPAR A00070
gene id: 27291:SPAR_A00070
uniprot id: A0A8B8UKK0
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

27291:SPAR N02120
gene id: 27291:SPAR_N02120
uniprot id: A0A8B8UYK2
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

27291:SPAR N01010
gene id: 27291:SPAR_N01010
uniprot id: A0A8B8UY89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SQS1 family.
messages: Cytoplasm
messages: Nucleus

27291:SPAR L02400
gene id: 27291:SPAR_L02400
uniprot id: A0A8B8UW21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Membrane
messages: nuclear pore complex

27291:SPAR C00890
gene id: 27291:SPAR_C00890
uniprot id: A0A8B8UMU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

27291:SPAR E00830
gene id: 27291:SPAR_E00830
uniprot id: A0A8B8UQ85
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR D05920
gene id: 27291:SPAR_D05920
uniprot id: A0A8B8UPB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

27291:SPAR L03830
gene id: 27291:SPAR_L03830
uniprot id: A0A8B8UWG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family.
messages: Membrane

27291:SPAR K00380
gene id: 27291:SPAR_K00380
uniprot id: A0A8B8UUQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LOT5 family.
messages: Nucleus

27291:SPAR B00890
gene id: 27291:SPAR_B00890
uniprot id: A0A8B8ULD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS10-related sortilin family.
messages: Membrane
messages: trans-Golgi network membrane

27291:SPAR C00360
gene id: 27291:SPAR_C00360
uniprot id: A0A8B8UMC8
names: Similarity
messages: In the C-terminal section; belongs to the histidinol dehydrogenase family.

27291:SPAR G03550
gene id: 27291:SPAR_G03550
uniprot id: A0A8B8URR7
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR B00710
gene id: 27291:SPAR_B00710
uniprot id: A0A8B8ULC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLASP family.
messages: spindle

27291:SPAR I00470
gene id: 27291:SPAR_I00470
uniprot id: A0A8B8UT35
names: Similarity
messages: Belongs to the SUN family.

27291:SPAR D04400
gene id: 27291:SPAR_D04400
uniprot id: A0A8B8UNY1
names: Similarity
messages: Belongs to the DEAD box helicase family.

27291:SPAR J01680
gene id: 27291:SPAR_J01680
uniprot id: A0A8B8UU46
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.
messages: Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.

27291:SPAR G02370
gene id: 27291:SPAR_G02370
uniprot id: A0A8B8URJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF beta subunit family.
messages: Nucleus

27291:SPAR B03470
gene id: 27291:SPAR_B03470
uniprot id: A0A8B8UM21
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

27291:SPAR D05740
gene id: 27291:SPAR_D05740
uniprot id: A0A8B8UPA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

27291:SPAR N00350
gene id: 27291:SPAR_N00350
uniprot id: A0A8B8UY73
names: Similarity
messages: Belongs to the DNA polymerase type-B-like family.

27291:SPAR K01800
gene id: 27291:SPAR_K01800
uniprot id: A0A8B8UV07
names: Function
names: Similarity
messages: Belongs to the TFIIE alpha subunit family.
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.

27291:SPAR D05580
gene id: 27291:SPAR_D05580
uniprot id: A0A8B8UPK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DXO/Dom3Z family.
messages: Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.
messages: Nucleus

27291:SPAR G03950
gene id: 27291:SPAR_G03950
uniprot id: A0A8B8URW0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

27291:SPAR B00150
gene id: 27291:SPAR_B00150
uniprot id: A0A8B8UL67
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aromatic-ring hydroxylase family. KMO subfamily.
messages: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.
messages: Mitochondrion outer membrane

27291:SPAR M01670
gene id: 27291:SPAR_M01670
uniprot id: A0A8B8UX57
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR M03170
gene id: 27291:SPAR_M03170
uniprot id: A0A8B8UXK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPA family.
messages: Nucleus

27291:SPAR D03250
gene id: 27291:SPAR_D03250
uniprot id: A0A8B8UNL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Nucleus

27291:SPAR D03150
gene id: 27291:SPAR_D03150
uniprot id: A0A8B8UNK9
names: Function
names: Similarity
messages: Belongs to the peptidase M24 family.
messages: Probable metalloprotease involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm.

27291:SPAR D06780
gene id: 27291:SPAR_D06780
uniprot id: A0A8B8UPK6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

27291:SPAR D02330
gene id: 27291:SPAR_D02330
uniprot id: A0A8B8ULI4
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

27291:SPAR H01090
gene id: 27291:SPAR_H01090
uniprot id: A0A8B8USI8
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

27291:SPAR O03300
gene id: 27291:SPAR_O03300
uniprot id: A0A8B8UZZ8
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

27291:SPAR P00340
gene id: 27291:SPAR_P00340
uniprot id: A0A8B8V0N8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP68 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.
messages: Cytoplasm
messages: nucleolus

27291:SPAR J00380
gene id: 27291:SPAR_J00380
uniprot id: A0A8B8UTR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG27 family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane

27291:SPAR G04870
gene id: 27291:SPAR_G04870
uniprot id: A0A8B8US86
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR G01600
gene id: 27291:SPAR_G01600
uniprot id: A0A8B8UR77
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR B01770
gene id: 27291:SPAR_B01770
uniprot id: A0A8B8ULJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family.
messages: Membrane

27291:SPAR L02310
gene id: 27291:SPAR_L02310
uniprot id: A0A8B8UW08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

27291:SPAR O04040
gene id: 27291:SPAR_O04040
uniprot id: A0A8B8V0B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

27291:SPAR I00300
gene id: 27291:SPAR_I00300
uniprot id: A0A8B8UT02
names: Similarity
messages: Belongs to the MAD2 family.

27291:SPAR D02210
gene id: 27291:SPAR_D02210
uniprot id: A0A8B8UNB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

27291:SPAR L01320
gene id: 27291:SPAR_L01320
uniprot id: A0A8B8UVV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BOS1 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: SNARE required for protein transport between the ER and the Golgi complex.

27291:SPAR B02250
gene id: 27291:SPAR_B02250
uniprot id: G4XSU3
names: Similarity
messages: Belongs to the glycosyltransferase 20 family.

27291:SPAR A00160
gene id: 27291:SPAR_A00160
uniprot id: A0A8B8UKV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.
messages: Mitochondrion outer membrane

27291:SPAR H01700
gene id: 27291:SPAR_H01700
uniprot id: A0A8B8UST8
names: Similarity
messages: Belongs to the actin family.

27291:SPAR H02550
gene id: 27291:SPAR_H02550
uniprot id: A0A8B8UT26
names: Similarity
messages: Belongs to the PhyH family.

27291:SPAR H01320
gene id: 27291:SPAR_H01320
uniprot id: A0A8B8USJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GAR1 family.
messages: Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
messages: Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.
messages: nucleolus

27291:SPAR K00970
gene id: 27291:SPAR_K00970
uniprot id: A0A8B8UUR5
names: Similarity
messages: Belongs to the p23/wos2 family.

27291:SPAR G00840
gene id: 27291:SPAR_G00840
uniprot id: A0A8B8URA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

27291:SPAR P04100
gene id: 27291:SPAR_P04100
uniprot id: A0A8B8V1M4
names: Similarity
messages: Belongs to the PAPS reductase family. CysH subfamily.

27291:SPAR G00430
gene id: 27291:SPAR_G00430
uniprot id: A0A8B8UQU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

27291:SPAR E02520
gene id: 27291:SPAR_E02520
uniprot id: A0A8B8UQD7
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).

27291:SPAR E01210
gene id: 27291:SPAR_E01210
uniprot id: A0A8B8UQ25
names: Similarity
messages: Belongs to the complex I LYR family.

27291:SPAR L02610
gene id: 27291:SPAR_L02610
uniprot id: A0A8B8UW39
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
messages: Cytoplasm
messages: Homodimer.

27291:SPAR D01280
gene id: 27291:SPAR_D01280
uniprot id: A0A8B8UNC8
names: Similarity
messages: Belongs to the putative lipase ROG1 family.

27291:SPAR L03910
gene id: 27291:SPAR_L03910
uniprot id: A0A8B8UWG8
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

27291:SPAR A00190
gene id: 27291:SPAR_A00190
uniprot id: A0A8B8UKV4
names: Similarity
messages: Belongs to the BolA/IbaG family.

27291:SPAR M03600
gene id: 27291:SPAR_M03600
uniprot id: A0A8B8UXQ9
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR M02320
gene id: 27291:SPAR_M02320
uniprot id: A0A8B8UXC0
names: Similarity
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.

27291:SPAR N02470
gene id: 27291:SPAR_N02470
uniprot id: A0A8B8UYN5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM6/GCD10 family.
messages: Heterotetramer.
messages: Nucleus
messages: Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

27291:SPAR A00540
gene id: 27291:SPAR_A00540
uniprot id: A0A8B8UKZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWC3 family.
messages: Nucleus

27291:SPAR L02050
gene id: 27291:SPAR_L02050
uniprot id: A0A8B8UVY4
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

27291:SPAR P01340
gene id: 27291:SPAR_P01340
uniprot id: A0A8B8V0Y5
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR H01470
gene id: 27291:SPAR_H01470
uniprot id: A0A8B8USL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YPT35 family.
messages: Endosome membrane
messages: Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.
messages: Vacuole membrane

27291:SPAR L02510
gene id: 27291:SPAR_L02510
uniprot id: A0A8B8UW30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCC1 family.
messages: Membrane

27291:SPAR C01370
gene id: 27291:SPAR_C01370
uniprot id: A0A8B8UMM8
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR L02640
gene id: 27291:SPAR_L02640
uniprot id: A0A8B8UW86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

27291:SPAR L02160
gene id: 27291:SPAR_L02160
uniprot id: A0A8B8UVZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTA1 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

27291:SPAR J01810
gene id: 27291:SPAR_J01810
uniprot id: A0A8B8UU71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
messages: Nucleus

27291:SPAR A00780
gene id: 27291:SPAR_A00780
uniprot id: A0A8B8ULH0
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

27291:SPAR B00440
gene id: 27291:SPAR_B00440
uniprot id: A0A8B8UL90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.
messages: spindle

27291:SPAR N00860
gene id: 27291:SPAR_N00860
uniprot id: A0A8B8UY77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG2 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Preautophagosomal structure membrane

27291:SPAR D03970
gene id: 27291:SPAR_D03970
uniprot id: A0A8B8UNS1
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.

27291:SPAR F00510
gene id: 27291:SPAR_F00510
uniprot id: A0A8B8UQJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR C00050
gene id: 27291:SPAR_C00050
uniprot id: A0A8B8UMA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MATALPHA1 family.
messages: Nucleus

27291:SPAR D07020
gene id: 27291:SPAR_D07020
uniprot id: A0A8B8UPP1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRB/QCR7 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

27291:SPAR L04500
gene id: 27291:SPAR_L04500
uniprot id: A0A8B8UWN0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

27291:SPAR P03040
gene id: 27291:SPAR_P03040
uniprot id: A0A8B8V1F4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

27291:SPAR M02590
gene id: 27291:SPAR_M02590
uniprot id: A0A8B8UNF4
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

27291:SPAR N01030
gene id: 27291:SPAR_N01030
uniprot id: A0A8B8UY91
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SSU72 phosphatase family.
messages: Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs.
messages: Component of the cleavage and polyadenylation factor (CPF) complex.
messages: Nucleus
messages: Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).

27291:SPAR B03910
gene id: 27291:SPAR_B03910
uniprot id: A0A8B8UM90
names: Similarity
messages: Belongs to the MAL13 family.

27291:SPAR B01870
gene id: 27291:SPAR_B01870
uniprot id: A0A8B8ULK4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL19 family.

27291:SPAR D04360
gene id: 27291:SPAR_D04360
uniprot id: A0A8B8UNX7
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

27291:SPAR M02370
gene id: 27291:SPAR_M02370
uniprot id: A0A8B8UXC5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

27291:SPAR I00150
gene id: 27291:SPAR_I00150
uniprot id: A0A8B8USY4
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

27291:SPAR P01480
gene id: 27291:SPAR_P01480
uniprot id: A0A8B8V0V0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase T2 family.
messages: Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration.
messages: Vacuole lumen

27291:SPAR O03680
gene id: 27291:SPAR_O03680
uniprot id: A0A8B8V030
names: Similarity
messages: Belongs to the TMA16 family.

27291:SPAR N01650
gene id: 27291:SPAR_N01650
uniprot id: A0A8B8UYK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

27291:SPAR M03280
gene id: 27291:SPAR_M03280
uniprot id: A0A8B8UXM2
names: Similarity
messages: Belongs to the EFR3 family.

27291:SPAR G00230
gene id: 27291:SPAR_G00230
uniprot id: A0A8B8UQS9
names: Similarity
messages: Belongs to the XPO2/CSE1 family.

27291:SPAR G03390
gene id: 27291:SPAR_G03390
uniprot id: A0A8B8US03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

27291:SPAR D01410
gene id: 27291:SPAR_D01410
uniprot id: A0A8B8UN31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

27291:SPAR D04620
gene id: 27291:SPAR_D04620
uniprot id: A0A8B8UNY4
names: Similarity
messages: Belongs to the ZNF598/HEL2 family.

27291:SPAR H02160
gene id: 27291:SPAR_H02160
uniprot id: A0A8B8USY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

27291:SPAR M01190
gene id: 27291:SPAR_M01190
uniprot id: A0A8B8UX73
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.
messages: Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.

27291:SPAR K00070
gene id: 27291:SPAR_K00070
uniprot id: A0A8B8UUH3
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

27291:SPAR L00120
gene id: 27291:SPAR_L00120
uniprot id: A0A8B8UVI6
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR D06570
gene id: 27291:SPAR_D06570
uniprot id: A0A8B8UPJ3
names: Subcellular Location Annotation
messages: Membrane
messages: Peroxisome membrane

27291:SPAR M00940
gene id: 27291:SPAR_M00940
uniprot id: A0A8B8UX46
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

27291:SPAR H00940
gene id: 27291:SPAR_H00940
uniprot id: A0A8B8USH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

27291:SPAR K02560
gene id: 27291:SPAR_K02560
uniprot id: A0A8B8UVD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR L03030
gene id: 27291:SPAR_L03030
uniprot id: A0A8B8UW87
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

27291:SPAR E00280
gene id: 27291:SPAR_E00280
uniprot id: A0A8B8UQ27
names: Similarity
messages: Belongs to the threonine aldolase family.

27291:SPAR J00710
gene id: 27291:SPAR_J00710
uniprot id: A0A8B8UTV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Nucleus

27291:SPAR N02680
gene id: 27291:SPAR_N02680
uniprot id: A0A8B8UYV3
names: Similarity
messages: Belongs to the PIGH family.

27291:SPAR K02720
gene id: 27291:SPAR_K02720
uniprot id: A0A8B8UV88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: cis-Golgi network

27291:SPAR N02810
gene id: 27291:SPAR_N02810
uniprot id: A0A8B8UYX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Membrane

27291:SPAR L04630
gene id: 27291:SPAR_L04630
uniprot id: A0A8B8UWP7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

27291:SPAR B00310
gene id: 27291:SPAR_B00310
uniprot id: A0A8B8UL77
names: Similarity
messages: Belongs to the non-repetitive/WGA-negative nucleoporin family.

27291:SPAR E01570
gene id: 27291:SPAR_E01570
uniprot id: A0A8B8UQ43
names: Similarity
messages: Belongs to the AIM9 family.

27291:SPAR D06990
gene id: 27291:SPAR_D06990
uniprot id: A0A8B8UPY9
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

27291:SPAR P00680
gene id: 27291:SPAR_P00680
uniprot id: A0A8B8V0M0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. RKM1 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase.

27291:SPAR B02440
gene id: 27291:SPAR_B02440
uniprot id: A0A8B8ULV1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

27291:SPAR N01070
gene id: 27291:SPAR_N01070
uniprot id: A0A8B8UYE2
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

27291:SPAR M03440
gene id: 27291:SPAR_M03440
uniprot id: A0A8B8UXU4
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase. Interacts with DNA in a non-specific manner.

27291:SPAR D05320
gene id: 27291:SPAR_D05320
uniprot id: A0A8B8UP58
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

27291:SPAR O01460
gene id: 27291:SPAR_O01460
uniprot id: A0A8B8UZG2
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR O03270
gene id: 27291:SPAR_O03270
uniprot id: A0A8B8V041
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.

27291:SPAR D06080
gene id: 27291:SPAR_D06080
uniprot id: A0A8B8UPQ3
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.

27291:SPAR D05180
gene id: 27291:SPAR_D05180
uniprot id: A0A8B8UPH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND3 (condensin subunit 3) family.
messages: Chromosome

27291:SPAR D04410
gene id: 27291:SPAR_D04410
uniprot id: A0A8B8UNY2
names: Similarity
messages: Belongs to the peroxisomal targeting signal receptor family.

27291:SPAR L00990
gene id: 27291:SPAR_L00990
uniprot id: A0A8B8UVM8
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.

27291:SPAR L00590
gene id: 27291:SPAR_L00590
uniprot id: A0A8B8UVI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF/MAK21 family.
messages: Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.
messages: nucleolus

27291:SPAR D06850
gene id: 27291:SPAR_D06850
uniprot id: A0A8B8UPL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I LYR family. SDHAF3 subfamily.
messages: Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.

27291:SPAR E00240
gene id: 27291:SPAR_E00240
uniprot id: A0A8B8UPR9
names: Similarity
messages: Belongs to the V-ATPase D subunit family.

27291:SPAR D04560
gene id: 27291:SPAR_D04560
uniprot id: A0A8B8UNZ8
names: Similarity
messages: Belongs to the APC13 family.

27291:SPAR H00990
gene id: 27291:SPAR_H00990
uniprot id: A0A8B8USI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.
messages: Component of the Mediator complex.
messages: Nucleus

27291:SPAR M00570
gene id: 27291:SPAR_M00570
uniprot id: A0A8B8UWV0
names: Similarity
messages: Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.

27291:SPAR N02050
gene id: 27291:SPAR_N02050
uniprot id: A0A8B8UYJ6
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR M04160
gene id: 27291:SPAR_M04160
uniprot id: A0A8B8UY06
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR N00120
gene id: 27291:SPAR_N00120
uniprot id: A0A8B8UY45
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

27291:SPAR M01840
gene id: 27291:SPAR_M01840
uniprot id: A0A8B8UXD7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAR5 family.
messages: Endoplasmic reticulum membrane
messages: Nucleus membrane
messages: Required for nuclear membrane fusion during karyogamy.

27291:SPAR L01930
gene id: 27291:SPAR_L01930
uniprot id: A0A8B8UVX0
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

27291:SPAR O00730
gene id: 27291:SPAR_O00730
uniprot id: A0A8B8UZ82
names: Function
names: Similarity
messages: Belongs to the REXO4 family.
messages: Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.

27291:SPAR K01010
gene id: 27291:SPAR_K01010
uniprot id: A0A8B8UUX6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Mitochondrion
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
messages: nucleolus
messages: nucleoplasm

27291:SPAR E01250
gene id: 27291:SPAR_E01250
uniprot id: A0A8B8UQ34
names: Similarity
messages: Belongs to the aspartokinase family.

27291:SPAR D01150
gene id: 27291:SPAR_D01150
uniprot id: A0A8B8UN04
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

27291:SPAR P00860
gene id: 27291:SPAR_P00860
uniprot id: A0A8B8V0T3
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR P03270
gene id: 27291:SPAR_P03270
uniprot id: A0A8B8V1D3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
messages: Belongs to the CNOT2/3/5 family.
messages: Cytoplasm
messages: Nucleus

27291:SPAR L03560
gene id: 27291:SPAR_L03560
uniprot id: A0A8B8UWD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Membrane
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.

27291:SPAR D04140
gene id: 27291:SPAR_D04140
uniprot id: A0A8B8UNV3
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR O00670
gene id: 27291:SPAR_O00670
uniprot id: A0A8B8UZC8
names: Similarity
messages: Belongs to the TAF9 family. CENP-S/MHF1 subfamily.

27291:SPAR P04270
gene id: 27291:SPAR_P04270
uniprot id: A0A8B8V1N0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG13 family. Fungi subfamily.
messages: Preautophagosomal structure

27291:SPAR L01190
gene id: 27291:SPAR_L01190
uniprot id: A0A8B8UVP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

27291:SPAR E01340
gene id: 27291:SPAR_E01340
uniprot id: A0A8B8UQ35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

27291:SPAR H01220
gene id: 27291:SPAR_H01220
uniprot id: A0A8B8USJ1
names: Similarity
messages: Belongs to the SWI5/SAE3 family.

27291:SPAR M01810
gene id: 27291:SPAR_M01810
uniprot id: A0A8B8UXB7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
messages: Heterodimer of an alpha and a beta chain.
messages: Mitochondrion matrix
messages: The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion.

27291:SPAR M03530
gene id: 27291:SPAR_M03530
uniprot id: A0A8B8UXP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

27291:SPAR B01880
gene id: 27291:SPAR_B01880
uniprot id: A0A8B8UM12
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Monomer.

27291:SPAR I00370
gene id: 27291:SPAR_I00370
uniprot id: A0A8B8UT24
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.

27291:SPAR M01550
gene id: 27291:SPAR_M01550
uniprot id: A0A8B8UX51
names: Similarity
messages: Belongs to the EIS1 family.

27291:SPAR A00180
gene id: 27291:SPAR_A00180
uniprot id: A0A8B8ULB4
names: Similarity
messages: Belongs to the BolA/IbaG family.

27291:SPAR G02420
gene id: 27291:SPAR_G02420
uniprot id: A0A8B8URJ5
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

27291:SPAR O01430
gene id: 27291:SPAR_O01430
uniprot id: A0A8B8UZF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Nucleus

27291:SPAR O02040
gene id: 27291:SPAR_O02040
uniprot id: A0A1L4AA23
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 heme c group covalently per subunit.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR F00910
gene id: 27291:SPAR_F00910
uniprot id: A0A8B8UQN0
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

27291:SPAR P00500
gene id: 27291:SPAR_P00500
uniprot id: A0A8B8V0L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.
messages: Cytoplasm

27291:SPAR P03260
gene id: 27291:SPAR_P03260
uniprot id: A0A8B8V1H1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 1 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

27291:SPAR B01240
gene id: 27291:SPAR_B01240
uniprot id: A0A8B8ULH3
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

27291:SPAR O04160
gene id: 27291:SPAR_O04160
uniprot id: A0A8B8V077
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRG7 family.
messages: Mitochondrion

27291:SPAR P00650
gene id: 27291:SPAR_P00650
uniprot id: A0A8B8V0M6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NIP7 family.
messages: Interacts with pre-ribosome complex.
messages: Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.
messages: nucleolus

27291:SPAR D00190
gene id: 27291:SPAR_D00190
uniprot id: A0A8B8UMR7
names: Similarity
messages: Belongs to the heat shock protein 70 family.

27291:SPAR J01080
gene id: 27291:SPAR_J01080
uniprot id: A0A8B8UTY0
names: Similarity
messages: Belongs to the SAPS family.

27291:SPAR D03940
gene id: 27291:SPAR_D03940
uniprot id: A0A8B8UNT5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.

27291:SPAR N00520
gene id: 27291:SPAR_N00520
uniprot id: A0A8B8UY85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

27291:SPAR M04460
gene id: 27291:SPAR_M04460
uniprot id: A0A8B8UY34
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

27291:SPAR D04760
gene id: 27291:SPAR_D04760
uniprot id: A0A8B8UP18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

27291:SPAR M00560
gene id: 27291:SPAR_M00560
uniprot id: A0A8B8UWZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMG-CoA reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR B01150
gene id: 27291:SPAR_B01150
uniprot id: A0A8B8ULH2
names: Similarity
messages: Belongs to the PPase family.

27291:SPAR P03520
gene id: 27291:SPAR_P03520
uniprot id: A0A8B8V1F7
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR G02600
gene id: 27291:SPAR_G02600
uniprot id: A0A8B8URH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 48 family.
messages: Membrane

27291:SPAR C00990
gene id: 27291:SPAR_C00990
uniprot id: A0A8B8UMV4
names: Similarity
messages: Belongs to the peptidase S8 family.

27291:SPAR K02960
gene id: 27291:SPAR_K02960
uniprot id: A0A8B8UVH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

27291:SPAR G00790
gene id: 27291:SPAR_G00790
uniprot id: A0A8B8UR94
names: Similarity
messages: Belongs to the CWC26 family.

27291:SPAR N02430
gene id: 27291:SPAR_N02430
uniprot id: A0A8B8UYS7
names: Similarity
messages: Belongs to the SUN family.

27291:SPAR G02510
gene id: 27291:SPAR_G02510
uniprot id: A0A8B8URK6
names: Similarity
messages: Belongs to the TACO1 family.

27291:SPAR L00130
gene id: 27291:SPAR_L00130
uniprot id: A0A8B8UVE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family.
messages: Nucleus matrix
messages: cytoskeleton

27291:SPAR M00580
gene id: 27291:SPAR_M00580
uniprot id: A0A8B8UWU9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

27291:SPAR O00920
gene id: 27291:SPAR_O00920
uniprot id: A0A8B8UZF3
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR M04430
gene id: 27291:SPAR_M04430
uniprot id: A0A8B8UXY8
names: Similarity
messages: Belongs to the peptidase A1 family.

27291:SPAR K00960
gene id: 27291:SPAR_K00960
uniprot id: A0A8B8UUX1
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR N02740
gene id: 27291:SPAR_N02740
uniprot id: A0A8B8UYR0
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

27291:SPAR H00910
gene id: 27291:SPAR_H00910
uniprot id: A0A8B8USJ5
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR O02670
gene id: 27291:SPAR_O02670
uniprot id: A0A8B8UZX5
names: Similarity
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Octamer of two non-identical subunits IDH1 and IDH2.

27291:SPAR D02700
gene id: 27291:SPAR_D02700
uniprot id: A0A8B8UNG3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

27291:SPAR P03930
gene id: 27291:SPAR_P03930
uniprot id: A0A8B8V1J5
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR J00720
gene id: 27291:SPAR_J00720
uniprot id: A0A8B8UTQ0
names: Similarity
messages: Belongs to the glycosyltransferase 15 family.

27291:SPAR H01810
gene id: 27291:SPAR_H01810
uniprot id: A0A8B8USU0
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR N00180
gene id: 27291:SPAR_N00180
uniprot id: A0A8B8UY01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR E01900
gene id: 27291:SPAR_E01900
uniprot id: A0A8B8UQA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

27291:SPAR M02850
gene id: 27291:SPAR_M02850
uniprot id: A0A8B8UXJ2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

27291:SPAR J03220
gene id: 27291:SPAR_J03220
uniprot id: A0A8B8USX8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

27291:SPAR G04030
gene id: 27291:SPAR_G04030
uniprot id: A0A8B8URW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

27291:SPAR G01820
gene id: 27291:SPAR_G01820
uniprot id: A0A8B8URD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

27291:SPAR G02800
gene id: 27291:SPAR_G02800
uniprot id: A0A8B8URJ0
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR O01770
gene id: 27291:SPAR_O01770
uniprot id: A0A8B8UZN8
names: Caution
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

27291:SPAR G02840
gene id: 27291:SPAR_G02840
uniprot id: A0A8B8URV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck

27291:SPAR P02090
gene id: 27291:SPAR_P02090
uniprot id: A0A8B8V160
names: Similarity
messages: Belongs to the glycosyltransferase 32 family.

27291:SPAR F01080
gene id: 27291:SPAR_F01080
uniprot id: A0A8B8UQQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

27291:SPAR L04050
gene id: 27291:SPAR_L04050
uniprot id: A0A8B8UWI6
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

27291:SPAR N00280
gene id: 27291:SPAR_N00280
uniprot id: A0A8B8UY11
names: Similarity
messages: Belongs to the KRI1 family.

27291:SPAR M03010
gene id: 27291:SPAR_M03010
uniprot id: A0A8B8UXN8
names: Similarity
messages: Belongs to the heat shock protein 90 family.

27291:SPAR I00070
gene id: 27291:SPAR_I00070
uniprot id: A0A8B8USZ4
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.

27291:SPAR B02660
gene id: 27291:SPAR_B02660
uniprot id: A0A8B8ULV9
names: Similarity
messages: Belongs to the prephenate/arogenate dehydrogenase family.

27291:SPAR L02070
gene id: 27291:SPAR_L02070
uniprot id: A0A8B8UW50
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

27291:SPAR E01880
gene id: 27291:SPAR_E01880
uniprot id: A0A8B8UQI1
names: Subcellular Location Annotation
messages: Cytoplasm

27291:SPAR B02270
gene id: 27291:SPAR_B02270
uniprot id: A0A8B8ULP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.

27291:SPAR O03990
gene id: 27291:SPAR_O03990
uniprot id: A0A8B8V0A6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with 90S and pre-40S pre-ribosomal particles. Interacts with CKA1, CKA2, CKB1, CKB2, PWP2, UTP15, UTP17 and UTP22.
messages: Belongs to the RRP36 family.
messages: Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.
messages: nucleolus

27291:SPAR J02080
gene id: 27291:SPAR_J02080
uniprot id: A0A8B8UU85
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR E00070
gene id: 27291:SPAR_E00070
uniprot id: A0A8B8UPP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR K00540
gene id: 27291:SPAR_K00540
uniprot id: A0A8B8UUM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.
messages: Membrane

27291:SPAR N03410
gene id: 27291:SPAR_N03410
uniprot id: A0A8B8UZ30
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

27291:SPAR L03660
gene id: 27291:SPAR_L03660
uniprot id: A0A8B8UWE3
names: Function
names: Similarity
messages: Belongs to the transaldolase family. Type 1 subfamily.
messages: Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.

27291:SPAR K01530
gene id: 27291:SPAR_K01530
uniprot id: A0A8B8UV25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.

27291:SPAR H01880
gene id: 27291:SPAR_H01880
uniprot id: A0A8B8USQ1
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

27291:SPAR D03730
gene id: 27291:SPAR_D03730
uniprot id: A0A8B8UP28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF10 family.
messages: Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation), facilitation of DNA opening and initiation of transcription. SAGA is required for recruitment of the basal transcription machinery. SLIK is proposed to have partly overlapping functions with SAGA.
messages: Nucleus

27291:SPAR J00250
gene id: 27291:SPAR_J00250
uniprot id: A0A8B8UTK0
names: Similarity
messages: Belongs to the CDC6/cdc18 family.

27291:SPAR G03510
gene id: 27291:SPAR_G03510
uniprot id: A0A8B8URV4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

27291:SPAR M03000
gene id: 27291:SPAR_M03000
uniprot id: A0A8B8UXK3
names: Similarity
messages: Belongs to the Tango6 family.

27291:SPAR L02690
gene id: 27291:SPAR_L02690
uniprot id: A0A8B8UW91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARV1 family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.
messages: Membrane
messages: Regulates also the sphingolipid metabolism.

27291:SPAR D03810
gene id: 27291:SPAR_D03810
uniprot id: A0A8B8UNS3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS35 family.
messages: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.
messages: Mitochondrion

27291:SPAR P02500
gene id: 27291:SPAR_P02500
uniprot id: A0A8B8V165
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

27291:SPAR L04530
gene id: 27291:SPAR_L04530
uniprot id: A0A8B8UWN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMG-CoA reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR G05010
gene id: 27291:SPAR_G05010
uniprot id: A0A8B8USA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR D04710
gene id: 27291:SPAR_D04710
uniprot id: A0A8B8UP14
names: Function
names: Subcellular Location Annotation
messages: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Nucleus

27291:SPAR H01340
gene id: 27291:SPAR_H01340
uniprot id: A0A8B8USM0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

27291:SPAR G04670
gene id: 27291:SPAR_G04670
uniprot id: A0A8B8US65
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
messages: Nucleus

27291:SPAR K02070
gene id: 27291:SPAR_K02070
uniprot id: A0A8B8UV20
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.

27291:SPAR B01140
gene id: 27291:SPAR_B01140
uniprot id: A0A8B8UYR4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H3 family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

27291:SPAR I00660
gene id: 27291:SPAR_I00660
uniprot id: A0A8B8UTC4
names: Similarity
messages: Belongs to the SHQ1 family.

27291:SPAR P01250
gene id: 27291:SPAR_P01250
uniprot id: A0A8B8V0T7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Mitochondrion
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of mitochondrial acyl-carrier-protein.

27291:SPAR M02230
gene id: 27291:SPAR_M02230
uniprot id: A0A8B8UXB3
names: Function
names: Similarity
messages: Belongs to the SPG4 family.
messages: Stationary phase-essential protein not required for growth on nonfermentable carbon sources.

27291:SPAR L00060
gene id: 27291:SPAR_L00060
uniprot id: A0A8B8UVC9
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

27291:SPAR O01250
gene id: 27291:SPAR_O01250
uniprot id: A0A8B8UZD3
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

27291:SPAR D05350
gene id: 27291:SPAR_D05350
uniprot id: A0A8B8UP83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR F00920
gene id: 27291:SPAR_F00920
uniprot id: A0A8B8UQZ2
names: Function
names: Similarity
messages: Belongs to the RRT5 family.
messages: May be involved in the modulation of rDNA transcription.

27291:SPAR M04180
gene id: 27291:SPAR_M04180
uniprot id: A0A8B8UXW0
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

27291:SPAR C00460
gene id: 27291:SPAR_C00460
uniprot id: A0A8B8UMD8
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

27291:SPAR B00070
gene id: 27291:SPAR_B00070
uniprot id: A0A8B8UKZ2
names: Similarity
messages: Belongs to the MIX23 family.

27291:SPAR D01540
gene id: 27291:SPAR_D01540
uniprot id: A0A8B8UN49
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

27291:SPAR O01320
gene id: 27291:SPAR_O01320
uniprot id: A0A8B8UZJ3
names: Similarity
messages: Belongs to the protein kinase superfamily.

27291:SPAR G01050
gene id: 27291:SPAR_G01050
uniprot id: A0A8B8UR23
names: Similarity
messages: Belongs to the putative lipase ROG1 family.

27291:SPAR F00700
gene id: 27291:SPAR_F00700
uniprot id: A0A8B8UQQ1
names: Similarity
messages: Belongs to the peptidase C19 family.

27291:SPAR M03650
gene id: 27291:SPAR_M03650
uniprot id: A0A8B8UXR4
names: Similarity
messages: Belongs to the group II decarboxylase family.

27291:SPAR D04390
gene id: 27291:SPAR_D04390
uniprot id: A0A8B8UNX8
names: Similarity
messages: Belongs to the amidase family.

27291:SPAR M00240
gene id: 27291:SPAR_M00240
uniprot id: A0A8B8UWY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with COQ3.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

27291:SPAR N00790
gene id: 27291:SPAR_N00790
uniprot id: A0A8B8UY71
names: Similarity
messages: Belongs to the SMC family. RAD50 subfamily.

27291:SPAR C00030
gene id: 27291:SPAR_C00030
uniprot id: A0A8B8UM95
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR L02340
gene id: 27291:SPAR_L02340
uniprot id: A0A8B8UW57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ9 family.
messages: Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.
messages: Mitochondrion

27291:SPAR D02050
gene id: 27291:SPAR_D02050
uniprot id: A0A8B8UN96
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

27291:SPAR L00810
gene id: 27291:SPAR_L00810
uniprot id: A0A8B8UVK7
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

27291:SPAR N03450
gene id: 27291:SPAR_N03450
uniprot id: A0A8B8UYY5
names: Similarity
messages: Belongs to the diphosphomevalonate decarboxylase family.

27291:SPAR G03970
gene id: 27291:SPAR_G03970
uniprot id: A0A8B8URZ9
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

27291:SPAR A00400
gene id: 27291:SPAR_A00400
uniprot id: A0A8B8UKZ7
names: Similarity
messages: Belongs to the MAK16 family.

27291:SPAR O02310
gene id: 27291:SPAR_O02310
uniprot id: A0A8B8UZQ0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS7 family.

27291:SPAR P01090
gene id: 27291:SPAR_P01090
uniprot id: A0A8B8V0W1
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

27291:SPAR L00350
gene id: 27291:SPAR_L00350
uniprot id: A0A8B8UVL9
names: Similarity
messages: Belongs to the heat shock protein 70 family.

27291:SPAR D02100
gene id: 27291:SPAR_D02100
uniprot id: A0A8B8UNA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Membrane

27291:SPAR C00580
gene id: 27291:SPAR_C00580
uniprot id: A0A8B8UMD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RER1 family.
messages: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.
messages: Membrane

27291:SPAR D00660
gene id: 27291:SPAR_D00660
uniprot id: A0A8B8UMV9
names: Similarity
messages: Belongs to the IMPACT family.

27291:SPAR G00140
gene id: 27291:SPAR_G00140
uniprot id: A0A8B8UR32
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase class-II family.

27291:SPAR J00470
gene id: 27291:SPAR_J00470
uniprot id: A0A8B8UTM8
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

27291:SPAR E00820
gene id: 27291:SPAR_E00820
uniprot id: A0A8B8UPX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.

27291:SPAR E01730
gene id: 27291:SPAR_E01730
uniprot id: A0A8B8UQG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM11 family.
messages: Membrane

27291:SPAR J00670
gene id: 27291:SPAR_J00670
uniprot id: A0A8B8UTP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFH5 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane
messages: Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane.

27291:SPAR L01660
gene id: 27291:SPAR_L01660
uniprot id: A0A8B8UVU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Nucleus

27291:SPAR E00740
gene id: 27291:SPAR_E00740
uniprot id: A0A8B8UPX2
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

27291:SPAR G03370
gene id: 27291:SPAR_G03370
uniprot id: A0A8B8URU2
names: Subcellular Location Annotation
messages: Nucleus membrane

27291:SPAR O02640
gene id: 27291:SPAR_O02640
uniprot id: A0A8B8UZW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the VPS17 family.
messages: Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport.
messages: Component of the retromer complex.

27291:SPAR L02930
gene id: 27291:SPAR_L02930
uniprot id: A0A8B8UW77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR A00690
gene id: 27291:SPAR_A00690
uniprot id: A0A8B8UL17
names: Similarity
messages: Belongs to the SAICAR synthetase family.

27291:SPAR P03250
gene id: 27291:SPAR_P03250
uniprot id: A0A8B8V1E0
names: Similarity
messages: Belongs to the spermidine/spermine synthase family.

27291:SPAR O03580
gene id: 27291:SPAR_O03580
uniprot id: A0A8B8V020
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A monovalent cation.
messages: Belongs to the folylpolyglutamate synthase family.
messages: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Required for methionine synthesis and maintenance of intact mitochondrial DNA. Involved in telomere maintenance.
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR H01190
gene id: 27291:SPAR_H01190
uniprot id: A0A8B8USK0
names: Subcellular Location Annotation
messages: Cytoplasm

27291:SPAR D00880
gene id: 27291:SPAR_D00880
uniprot id: A0A8B8UN88
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR J00410
gene id: 27291:SPAR_J00410
uniprot id: A0A8B8UTT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRE9/KNH1 family.
messages: Involved in cell wall beta(1->6) glucan synthesis.
messages: cell wall

27291:SPAR J03070
gene id: 27291:SPAR_J03070
uniprot id: A0A8B8UUD9
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

27291:SPAR C00430
gene id: 27291:SPAR_C00430
uniprot id: A0A8B8UMB2
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.

27291:SPAR O04650
gene id: 27291:SPAR_O04650
uniprot id: A0A8B8V0C8
names: Function
names: Similarity
messages: Belongs to the peptidase T1A family.
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

27291:SPAR E00660
gene id: 27291:SPAR_E00660
uniprot id: A0A8B8UPW6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR H00690
gene id: 27291:SPAR_H00690
uniprot id: A0A8B8USE9
names: Function
names: Similarity
messages: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
messages: Belongs to the proteasome subunit S2 family.

27291:SPAR I00990
gene id: 27291:SPAR_I00990
uniprot id: A0A8B8UTB3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIS1 family.
messages: Has a role in mitochondrial fission.
messages: Membrane
messages: Mitochondrion outer membrane
messages: The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.

27291:SPAR P01950
gene id: 27291:SPAR_P01950
uniprot id: A0A8B8V108
names: Similarity
messages: Belongs to the peptidase C19 family.

27291:SPAR D02170
gene id: 27291:SPAR_D02170
uniprot id: A0A8B8UN90
names: Similarity
messages: Belongs to the AAA ATPase family.

27291:SPAR I00080
gene id: 27291:SPAR_I00080
uniprot id: D5MS32
names: Similarity
messages: Belongs to the glycosyl hydrolase 32 family.

27291:SPAR B00430
gene id: 27291:SPAR_B00430
uniprot id: A0A8B8ULM0
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

27291:SPAR D00480
gene id: 27291:SPAR_D00480
uniprot id: A0A8B8UN48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

27291:SPAR J02190
gene id: 27291:SPAR_J02190
uniprot id: A0A8B8UU59
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR M00620
gene id: 27291:SPAR_M00620
uniprot id: A0A8B8UWV5
names: Function
names: Similarity
messages: Belongs to the dihydroxyacetone kinase (DAK) family.
messages: Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.

27291:SPAR O04380
gene id: 27291:SPAR_O04380
uniprot id: A0A8B8V099
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

27291:SPAR H02480
gene id: 27291:SPAR_H02480
uniprot id: A0A8B8USW0
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR D01700
gene id: 27291:SPAR_D01700
uniprot id: A0A8B8UN62
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

27291:SPAR J00960
gene id: 27291:SPAR_J00960
uniprot id: A0A8B8UTY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.

27291:SPAR L03410
gene id: 27291:SPAR_L03410
uniprot id: A0A8B8UWC1
names: Subcellular Location Annotation
messages: Membrane
messages: Peroxisome membrane

27291:SPAR E02370
gene id: 27291:SPAR_E02370
uniprot id: A0A8B8UQC2
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

27291:SPAR B01020
gene id: 27291:SPAR_B01020
uniprot id: A0A8B8ULB3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

27291:SPAR D05760
gene id: 27291:SPAR_D05760
uniprot id: A0A8B8UPB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPF family.
messages: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
messages: Interacts with EME1.
messages: Nucleus

27291:SPAR G01830
gene id: 27291:SPAR_G01830
uniprot id: A0A8B8UR93
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

27291:SPAR B02950
gene id: 27291:SPAR_B02950
uniprot id: A0A8B8UM00
names: Function
names: Similarity
messages: Belongs to the GPI family.
messages: In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.

27291:SPAR L00880
gene id: 27291:SPAR_L00880
uniprot id: A0A8B8UVL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

27291:SPAR G01670
gene id: 27291:SPAR_G01670
uniprot id: A0A8B8URB7
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR G04450
gene id: 27291:SPAR_G04450
uniprot id: A0A8B8US09
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

27291:SPAR L01030
gene id: 27291:SPAR_L01030
uniprot id: A0A8B8UVM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.
messages: Cytoplasm
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.

27291:SPAR D06740
gene id: 27291:SPAR_D06740
uniprot id: A0A8B8UPW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR H01580
gene id: 27291:SPAR_H01580
uniprot id: A0A8B8USV6
names: Subcellular Location Annotation
messages: Mitochondrion intermembrane space

27291:SPAR P00790
gene id: 27291:SPAR_P00790
uniprot id: A0A8B8V0T0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 3 (AP-3) is a heterotetramer.
messages: Belongs to the adaptor complexes large subunit family.
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.

27291:SPAR O03610
gene id: 27291:SPAR_O03610
uniprot id: A0A8B8V022
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

27291:SPAR K01820
gene id: 27291:SPAR_K01820
uniprot id: A0A8B8UUZ9
names: Similarity
messages: Belongs to the glutathione peroxidase family.

27291:SPAR K01970
gene id: 27291:SPAR_K01970
uniprot id: A0A8B8UV14
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR G02300
gene id: 27291:SPAR_G02300
uniprot id: A0A8B8URE5
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

27291:SPAR N02660
gene id: 27291:SPAR_N02660
uniprot id: A0A8B8UYV7
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.

27291:SPAR N03300
gene id: 27291:SPAR_N03300
uniprot id: A0A8B8UYX0
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

27291:SPAR D00380
gene id: 27291:SPAR_D00380
uniprot id: A0A8B8UN38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

27291:SPAR J02820
gene id: 27291:SPAR_J02820
uniprot id: A0A8B8UUB6
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

27291:SPAR L01690
gene id: 27291:SPAR_L01690
uniprot id: A0A8B8UVU5
names: Function
messages: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.

27291:SPAR D02670
gene id: 27291:SPAR_D02670
uniprot id: A0A8B8UNE1
names: Similarity
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Homodimer.

27291:SPAR J01520
gene id: 27291:SPAR_J01520
uniprot id: A0A8B8UTZ4
names: Similarity
messages: Belongs to the helicase family. SKI2 subfamily.

27291:SPAR O04350
gene id: 27291:SPAR_O04350
uniprot id: A0A1L4AA54
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR B00340
gene id: 27291:SPAR_B00340
uniprot id: A0A8B8UL76
names: Similarity
messages: Belongs to the heat shock protein 70 family.

27291:SPAR C00490
gene id: 27291:SPAR_C00490
uniprot id: A0A8B8UMQ8
names: Similarity
messages: Belongs to the UPF0357 family.

27291:SPAR E00060
gene id: 27291:SPAR_E00060
uniprot id: A0A8B8UPQ8
names: Similarity
messages: Belongs to the mannitol dehydrogenase family.

27291:SPAR N01620
gene id: 27291:SPAR_N01620
uniprot id: A0A8B8UYJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR J00340
gene id: 27291:SPAR_J00340
uniprot id: A0A8B8UTN9
names: Similarity
messages: Belongs to the glycosyltransferase 34 family.

27291:SPAR O04590
gene id: 27291:SPAR_O04590
uniprot id: A0A8B8V0G5
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

27291:SPAR L02710
gene id: 27291:SPAR_L02710
uniprot id: A0A8B8UW49
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

27291:SPAR D01100
gene id: 27291:SPAR_D01100
uniprot id: A0A8B8UN01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.
messages: Membrane
messages: Vacuole membrane

27291:SPAR M03450
gene id: 27291:SPAR_M03450
uniprot id: A0A8B8UXP5
names: Subcellular Location Annotation
messages: nucleolus

27291:SPAR E00520
gene id: 27291:SPAR_E00520
uniprot id: A0A8B8UPU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSE2 family.
messages: Nucleus

27291:SPAR E02040
gene id: 27291:SPAR_E02040
uniprot id: A0A8B8UQA1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.
messages: Component of the pre-66S ribosomal particle.
messages: Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.
messages: nucleolus

27291:SPAR J02390
gene id: 27291:SPAR_J02390
uniprot id: A0A8B8UU77
names: Similarity
messages: Belongs to the thymidylate kinase family.

27291:SPAR D05410
gene id: 27291:SPAR_D05410
uniprot id: A0A8B8UP80
names: Subcellular Location Annotation
messages: Golgi apparatus

27291:SPAR D05940
gene id: 27291:SPAR_D05940
uniprot id: A0A8B8UPD0
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR D01570
gene id: 27291:SPAR_D01570
uniprot id: A0A8B8UN30
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

27291:A560 mgp02
gene id: 27291:A560_mgp02
uniprot id: I1Z693
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Mitochondrion

27291:SPAR I00390
gene id: 27291:SPAR_I00390
uniprot id: A0A8B8UT59
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR L02230
gene id: 27291:SPAR_L02230
uniprot id: A0A8B8UW06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family.
messages: Cytoplasm
messages: Membrane

27291:SPAR L02520
gene id: 27291:SPAR_L02520
uniprot id: A0A8B8UW96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RSA3 family.
messages: Required for efficient biogenesis of the 60S ribosomal subunit.
messages: nucleolus

27291:SPAR D00280
gene id: 27291:SPAR_D00280
uniprot id: A0A8B8UN27
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR P00520
gene id: 27291:SPAR_P00520
uniprot id: A0A8B8V0K7
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR G04800
gene id: 27291:SPAR_G04800
uniprot id: A0A8B8US50
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR C01120
gene id: 27291:SPAR_C01120
uniprot id: A0A8B8UMK2
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR O01280
gene id: 27291:SPAR_O01280
uniprot id: A0A8B8UZD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

27291:SPAR O03230
gene id: 27291:SPAR_O03230
uniprot id: A0A8B8UZY7
names: Similarity
messages: Belongs to the peptidase C14B family.

27291:SPAR J03320
gene id: 27291:SPAR_J03320
uniprot id: A0A8B8UMP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NMT1/THI5 family.
messages: Homodimer.
messages: Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.

27291:SPAR D07000
gene id: 27291:SPAR_D07000
uniprot id: A0A8B8UPN7
names: Similarity
messages: Belongs to the RPAP1 family.

27291:SPAR C01240
gene id: 27291:SPAR_C01240
uniprot id: A0A8B8UMX9
names: Similarity
messages: Belongs to the PAT1 family.

27291:SPAR O02620
gene id: 27291:SPAR_O02620
uniprot id: A0A8B8UZX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

27291:SPAR L00570
gene id: 27291:SPAR_L00570
uniprot id: A0A8B8UVN1
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

27291:SPAR B02780
gene id: 27291:SPAR_B02780
uniprot id: A0A8B8UM96
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR P00480
gene id: 27291:SPAR_P00480
uniprot id: A0A8B8V0K0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fungal TPase family.
messages: First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.
messages: Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.
messages: Nucleus

27291:SPAR M01420
gene id: 27291:SPAR_M01420
uniprot id: A0A8B8UX31
names: Similarity
messages: Belongs to the peroxisomal targeting signal receptor family.

27291:SPAR M01020
gene id: 27291:SPAR_M01020
uniprot id: A0A8B8UWY9
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

27291:SPAR M02920
gene id: 27291:SPAR_M02920
uniprot id: A0A8B8UXH9
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR G01420
gene id: 27291:SPAR_G01420
uniprot id: A0A8B8UR92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR N00140
gene id: 27291:SPAR_N00140
uniprot id: A0A8B8UY04
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

27291:SPAR H02340
gene id: 27291:SPAR_H02340
uniprot id: A0A8B8UT34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAC-alpha family.
messages: Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD2 may also be involved in transcription regulation.
messages: Cytoplasm
messages: Nucleus

27291:SPAR M04280
gene id: 27291:SPAR_M04280
uniprot id: A0A8B8UXX0
names: Similarity
messages: Belongs to the ELP6 family.

27291:SPAR A00010
gene id: 27291:SPAR_A00010
uniprot id: A0A8B8UKT0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

27291:SPAR J01060
gene id: 27291:SPAR_J01060
uniprot id: A0A8B8UTZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family.
messages: Cell membrane
messages: Vacuole membrane

27291:SPAR G01870
gene id: 27291:SPAR_G01870
uniprot id: A0A8B8URE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

27291:SPAR O04690
gene id: 27291:SPAR_O04690
uniprot id: A0A8B8V0H5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes.
messages: Nucleus

27291:SPAR L01390
gene id: 27291:SPAR_L01390
uniprot id: A0A8B8UVR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family.
messages: Nucleus

27291:SPAR B02310
gene id: 27291:SPAR_B02310
uniprot id: A0A8B8ULS7
names: Similarity
messages: Belongs to the CCZ1 family.

27291:SPAR B00180
gene id: 27291:SPAR_B00180
uniprot id: A0A8B8ULJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 19 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

27291:SPAR B01810
gene id: 27291:SPAR_B01810
uniprot id: A0A8B8ULM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit A family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.

27291:SPAR P00210
gene id: 27291:SPAR_P00210
uniprot id: A0A8B8V0L9
names: Function
names: Similarity
messages: Belongs to the cyclin family.
messages: G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition.

27291:SPAR D05200
gene id: 27291:SPAR_D05200
uniprot id: A0A8B8UP68
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SKP1 family.
messages: Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.
messages: Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.

27291:SPAR P02720
gene id: 27291:SPAR_P02720
uniprot id: A0A8B8V180
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

27291:SPAR N00750
gene id: 27291:SPAR_N00750
uniprot id: A0A8B8UYB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RTC4 family.
messages: May be involved in a process influencing telomere capping.
messages: Nucleus

27291:SPAR M04170
gene id: 27291:SPAR_M04170
uniprot id: A0A8B8UXV7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YME2 family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA.

27291:SPAR M01740
gene id: 27291:SPAR_M01740
uniprot id: A0A8B8UXC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

27291:SPAR D06450
gene id: 27291:SPAR_D06450
uniprot id: A0A8B8UPI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus
messages: S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.

27291:SPAR B02620
gene id: 27291:SPAR_B02620
uniprot id: A0A8B8ULT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.

27291:SPAR P02790
gene id: 27291:SPAR_P02790
uniprot id: A0A8B8V1D0
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR F00410
gene id: 27291:SPAR_F00410
uniprot id: A0A8B8UQI4
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.

27291:SPAR G01540
gene id: 27291:SPAR_G01540
uniprot id: A0A8B8URG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export.
messages: Cytoplasm
messages: Nucleus

27291:SPAR B00560
gene id: 27291:SPAR_B00560
uniprot id: A0A8B8ULA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

27291:SPAR D01020
gene id: 27291:SPAR_D01020
uniprot id: A0A8B8UMX3
names: Similarity
messages: Belongs to the Rho GDI family.

27291:SPAR G04390
gene id: 27291:SPAR_G04390
uniprot id: A0A8B8US98
names: Similarity
messages: Belongs to the KNR4/SMI1 family.

27291:SPAR N00640
gene id: 27291:SPAR_N00640
uniprot id: A0A8B8UY56
names: Similarity
messages: Belongs to the IST1 family.

27291:SPAR O02710
gene id: 27291:SPAR_O02710
uniprot id: A0A8B8UZU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin family.
messages: Nucleus
messages: Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex.

27291:SPAR B02600
gene id: 27291:SPAR_B02600
uniprot id: A0A8B8ULW5
names: Similarity
messages: Belongs to the glycosyltransferase 32 family.

27291:SPAR D04050
gene id: 27291:SPAR_D04050
uniprot id: A0A8B8UNU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex SPC19 family.
messages: Nucleus
messages: kinetochore

27291:SPAR H00820
gene id: 27291:SPAR_H00820
uniprot id: A0A8B8USF1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

27291:SPAR B00300
gene id: 27291:SPAR_B00300
uniprot id: A0A8B8UL87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A, B and F subunits.

27291:SPAR G00850
gene id: 27291:SPAR_G00850
uniprot id: A0A8B8UR03
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

27291:SPAR K01740
gene id: 27291:SPAR_K01740
uniprot id: A0A8B8UUZ3
names: Function
names: Similarity
messages: Belongs to the UDPGP type 1 family.
messages: Plays a central role as a glucosyl donor in cellular metabolic pathways.

27291:SPAR E00770
gene id: 27291:SPAR_E00770
uniprot id: A0A8B8UPW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMA20 family.
messages: Cytoplasm
messages: Involved in translation.

27291:SPAR O00600
gene id: 27291:SPAR_O00600
uniprot id: A0A8B8UZ68
names: Subunit
messages: Monomer.

27291:SPAR B02550
gene id: 27291:SPAR_B02550
uniprot id: A0A8B8ULW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INCENP family.
messages: Nucleus
messages: spindle

27291:SPAR D05970
gene id: 27291:SPAR_D05970
uniprot id: A0A8B8UPC2
names: Similarity
messages: Belongs to the PIAS family.

27291:SPAR B01640
gene id: 27291:SPAR_B01640
uniprot id: A0A8B8ULL6
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

27291:SPAR N00610
gene id: 27291:SPAR_N00610
uniprot id: A0A8B8UY52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

27291:SPAR B00980
gene id: 27291:SPAR_B00980
uniprot id: A0A8B8ULS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLA1 family.
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

27291:SPAR L00520
gene id: 27291:SPAR_L00520
uniprot id: A0A8B8UVM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MMM1 family.
messages: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
messages: Endoplasmic reticulum membrane
messages: Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.

27291:SPAR M02810
gene id: 27291:SPAR_M02810
uniprot id: A0A8B8UXL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR L04450
gene id: 27291:SPAR_L04450
uniprot id: A0A8B8UWM4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).
messages: Cytoplasm

27291:SPAR O00150
gene id: 27291:SPAR_O00150
uniprot id: A0A8B8UZ24
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

27291:SPAR D01680
gene id: 27291:SPAR_D01680
uniprot id: A0A8B8UNH0
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

27291:SPAR O01800
gene id: 27291:SPAR_O01800
uniprot id: A0A8B8UZI8
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

27291:SPAR P01490
gene id: 27291:SPAR_P01490
uniprot id: A0A8B8V100
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
messages: Nucleus

27291:SPAR D04930
gene id: 27291:SPAR_D04930
uniprot id: A0A8B8UPE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGF family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR H02130
gene id: 27291:SPAR_H02130
uniprot id: A0A8B8USS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TUBGCP family.
messages: microtubule organizing center

27291:SPAR M02340
gene id: 27291:SPAR_M02340
uniprot id: A0A8B8UXI5
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR G03600
gene id: 27291:SPAR_G03600
uniprot id: A0A8B8URS3
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THI4 family.
messages: Binds 1 Fe cation per subunit.
messages: Cytoplasm
messages: During the catalytic reaction, a sulfide is transferred from Cys-205 to a reaction intermediate, generating a dehydroalanine residue.
messages: Homooctamer.
messages: Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.
messages: Nucleus

27291:SPAR I00320
gene id: 27291:SPAR_I00320
uniprot id: A0A8B8UT21
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

27291:SPAR D05150
gene id: 27291:SPAR_D05150
uniprot id: A0A8B8UP63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase e subunit family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion inner membrane

27291:SPAR K02020
gene id: 27291:SPAR_K02020
uniprot id: A0A8B8UV18
names: Function
names: Similarity
names: Subunit
messages: Belongs to the F-actin-capping protein alpha subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.

27291:SPAR I01110
gene id: 27291:SPAR_I01110
uniprot id: A0A8B8UTG6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

27291:SPAR B01920
gene id: 27291:SPAR_B01920
uniprot id: A0A8B8ULL1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PCNA family.
messages: Nucleus
messages: This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.

27291:SPAR E02090
gene id: 27291:SPAR_E02090
uniprot id: A0A8B8UQA7
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS26 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.

27291:SPAR O00510
gene id: 27291:SPAR_O00510
uniprot id: A0A8B8UZ63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR D05980
gene id: 27291:SPAR_D05980
uniprot id: A0A8B8UPP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR K02400
gene id: 27291:SPAR_K02400
uniprot id: A0A8B8UV68
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR E00870
gene id: 27291:SPAR_E00870
uniprot id: A0A8B8UPX9
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

27291:SPAR G00880
gene id: 27291:SPAR_G00880
uniprot id: A0A8B8UQZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

27291:SPAR M03810
gene id: 27291:SPAR_M03810
uniprot id: A0A8B8UXX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

27291:SPAR C00150
gene id: 27291:SPAR_C00150
uniprot id: A0A8B8UMB6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
messages: nucleolus

27291:SPAR K01430
gene id: 27291:SPAR_K01430
uniprot id: A0A8B8UV19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin GLFG family.
messages: Nucleus membrane
messages: nuclear pore complex

27291:SPAR D01670
gene id: 27291:SPAR_D01670
uniprot id: A0A8B8UN40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fungal cytochrome c oxidase subunit 7a family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR O02730
gene id: 27291:SPAR_O02730
uniprot id: A0A8B8UZT8
names: Similarity
messages: Belongs to the thiamine pyrophosphokinase family.

27291:SPAR E02530
gene id: 27291:SPAR_E02530
uniprot id: A0A8B8UQP6
names: Similarity
messages: Belongs to the RecA family. DMC1 subfamily.

27291:SPAR O02190
gene id: 27291:SPAR_O02190
uniprot id: A0A8B8UZS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WHI5/NRM1 family.
messages: Cytoplasm
messages: Nucleus

27291:SPAR G00810
gene id: 27291:SPAR_G00810
uniprot id: A0A8B8UR36
names: Subcellular Location Annotation
messages: Nucleus membrane
messages: nuclear pore complex

27291:SPAR E02220
gene id: 27291:SPAR_E02220
uniprot id: A0A8B8UQB0
names: Similarity
messages: Belongs to the SCC4/mau-2 family.

27291:SPAR D00870
gene id: 27291:SPAR_D00870
uniprot id: A0A8B8UMV7
names: Similarity
messages: Belongs to the SAS10 family.

27291:SPAR L04260
gene id: 27291:SPAR_L04260
uniprot id: A0A8B8UWK5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

27291:SPAR J02730
gene id: 27291:SPAR_J02730
uniprot id: A0A8B8UUF7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL43 family.

27291:SPAR G00910
gene id: 27291:SPAR_G00910
uniprot id: A0A8B8UR44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferric reductase (FRE) family.
messages: Membrane

27291:SPAR M01010
gene id: 27291:SPAR_M01010
uniprot id: A0A8B8UX42
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR D00360
gene id: 27291:SPAR_D00360
uniprot id: A0A8B8UMS8
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR M02290
gene id: 27291:SPAR_M02290
uniprot id: A0A8B8UXI1
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

27291:SPAR M00090
gene id: 27291:SPAR_M00090
uniprot id: A0A8B8UWW7
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

27291:SPAR O00930
gene id: 27291:SPAR_O00930
uniprot id: A0A8B8UZA5
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

27291:SPAR B01070
gene id: 27291:SPAR_B01070
uniprot id: A0A8B8ULB8
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

27291:SPAR D06290
gene id: 27291:SPAR_D06290
uniprot id: A0A8B8UPS0
names: Function
names: Subcellular Location Annotation
messages: Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation.
messages: Nucleus

27291:SPAR G02120
gene id: 27291:SPAR_G02120
uniprot id: A0A8B8URG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

27291:SPAR O01080
gene id: 27291:SPAR_O01080
uniprot id: A0A8B8UZB9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Nth/MutY family.
messages: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion
messages: Nucleus

27291:SPAR M03200
gene id: 27291:SPAR_M03200
uniprot id: A0A8B8UXM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INP1 family.
messages: Membrane
messages: Peroxisome membrane
messages: Required for peroxisome inheritance.

27291:SPAR M03960
gene id: 27291:SPAR_M03960
uniprot id: A0A8B8UXY6
names: Function
names: Similarity
messages: Belongs to the PIGL family.
messages: Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.

27291:SPAR J03350
gene id: 27291:SPAR_J03350
uniprot id: A0A8B8UUH5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

27291:SPAR O02880
gene id: 27291:SPAR_O02880
uniprot id: A0A8B8UZV4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.
messages: Nucleus

27291:SPAR B03440
gene id: 27291:SPAR_B03440
uniprot id: A0A8B8UM50
names: Function
names: Similarity
messages: Belongs to the HisA/HisF family.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.
messages: In the C-terminal section; belongs to the HisA/HisF family.

27291:SPAR N03680
gene id: 27291:SPAR_N03680
uniprot id: A0A8B8UZ51
names: Similarity
messages: Belongs to the glycosyl hydrolase 81 family.

27291:SPAR G02270
gene id: 27291:SPAR_G02270
uniprot id: A0A8B8URI2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

27291:SPAR P01300
gene id: 27291:SPAR_P01300
uniprot id: A0A8B8V0U2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

27291:SPAR E01100
gene id: 27291:SPAR_E01100
uniprot id: A0A8B8UQ22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TPT transporter family. SLC35D subfamily.
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homooligomer.
messages: Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.

27291:SPAR O03530
gene id: 27291:SPAR_O03530
uniprot id: A0A8B8V018
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

27291:SPAR H00270
gene id: 27291:SPAR_H00270
uniprot id: A0A8B8US90
names: Similarity
messages: Belongs to the universal ribosomal protein uS10 family.

27291:SPAR L01720
gene id: 27291:SPAR_L01720
uniprot id: A0A8B8UVZ2
names: Similarity
messages: Belongs to the peptidase A1 family.

27291:SPAR M01950
gene id: 27291:SPAR_M01950
uniprot id: A0A8B8UX93
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR M00290
gene id: 27291:SPAR_M00290
uniprot id: A0A8B8UWY3
names: Subcellular Location Annotation
messages: Cytoplasm

27291:SPAR K00420
gene id: 27291:SPAR_K00420
uniprot id: A0A8B8UUL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CASP family.
messages: Golgi apparatus membrane
messages: Membrane

27291:SPAR N03720
gene id: 27291:SPAR_N03720
uniprot id: A0A8B8UZ10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR N02060
gene id: 27291:SPAR_N02060
uniprot id: A0A8B8UYP7
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

27291:SPAR D03320
gene id: 27291:SPAR_D03320
uniprot id: A0A8B8UNK6
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.

27291:SPAR O04290
gene id: 27291:SPAR_O04290
uniprot id: A0A8B8V0D6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

27291:SPAR L02760
gene id: 27291:SPAR_L02760
uniprot id: A0A8B8UW56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.
messages: Cytoplasm

27291:SPAR D04850
gene id: 27291:SPAR_D04850
uniprot id: A0A8B8UP29
names: Similarity
messages: Belongs to the group II decarboxylase family.

27291:SPAR I00490
gene id: 27291:SPAR_I00490
uniprot id: A0A8B8UT69
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR K02860
gene id: 27291:SPAR_K02860
uniprot id: A0A8B8UVG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex DAD2 family.
messages: Nucleus
messages: kinetochore
messages: spindle

27291:SPAR P01360
gene id: 27291:SPAR_P01360
uniprot id: A0A8B8V0Y2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NifU family.
messages: Mitochondrion matrix
messages: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.

27291:SPAR O04540
gene id: 27291:SPAR_O04540
uniprot id: A0A8B8V0G0
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.

27291:SPAR M04190
gene id: 27291:SPAR_M04190
uniprot id: A0A8B8UY17
names: Similarity
messages: Belongs to the peptidase C19 family.

27291:SPAR P02200
gene id: 27291:SPAR_P02200
uniprot id: A0A8B8V135
names: Similarity
messages: Belongs to the SKP1 family.

27291:SPAR G03280
gene id: 27291:SPAR_G03280
uniprot id: A0A8B8URN4
names: Similarity
messages: Belongs to the cyclin family.

27291:SPAR K00260
gene id: 27291:SPAR_K00260
uniprot id: A0A8B8UUP7
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

27291:SPAR L00040
gene id: 27291:SPAR_L00040
uniprot id: A0A8B8UVD7
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR P03620
gene id: 27291:SPAR_P03620
uniprot id: A0A8B8V1G5
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR O02540
gene id: 27291:SPAR_O02540
uniprot id: A0A8B8UZV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the profilin family.
messages: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.
messages: Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

27291:SPAR K02100
gene id: 27291:SPAR_K02100
uniprot id: A0A8B8UV39
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

27291:SPAR E02030
gene id: 27291:SPAR_E02030
uniprot id: A0A8B8UQJ8
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR J00420
gene id: 27291:SPAR_J00420
uniprot id: A0A8B8UTM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the replication factor A protein 3 family.
messages: Nucleus

27291:SPAR A00520
gene id: 27291:SPAR_A00520
uniprot id: A0A8B8UKT6
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR G02330
gene id: 27291:SPAR_G02330
uniprot id: A0A8B8URE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates elongation factor 1-alpha at 'Lys-79'.

27291:SPAR N02270
gene id: 27291:SPAR_N02270
uniprot id: A0A8B8UYL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR M02160
gene id: 27291:SPAR_M02160
uniprot id: A0A8B8UXF2
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate 1-epimerase family.
messages: Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).

27291:SPAR L03140
gene id: 27291:SPAR_L03140
uniprot id: A0A8B8UWD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ran family.
messages: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.
messages: Nucleus

27291:SPAR N02280
gene id: 27291:SPAR_N02280
uniprot id: A0A8B8UYR1
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

27291:SPAR M03270
gene id: 27291:SPAR_M03270
uniprot id: A0A8B8UXL8
names: Function
names: Similarity
messages: Belongs to the misato family.
messages: Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.

27291:SPAR B00200
gene id: 27291:SPAR_B00200
uniprot id: A0A8B8UL74
names: Similarity
messages: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.

27291:SPAR L02700
gene id: 27291:SPAR_L02700
uniprot id: A0A8B8UW47
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

27291:SPAR N01960
gene id: 27291:SPAR_N01960
uniprot id: A0A8B8UYN6
names: Similarity
messages: Belongs to the Nudix hydrolase family. DCP2 subfamily.

27291:SPAR D05330
gene id: 27291:SPAR_D05330
uniprot id: A0A8B8UPI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR N03330
gene id: 27291:SPAR_N03330
uniprot id: A0A8B8UZ19
names: Similarity
messages: Belongs to the PPP phosphatase family.

27291:SPAR C01180
gene id: 27291:SPAR_C01180
uniprot id: A0A8B8UMI7
names: Subcellular Location Annotation
messages: nucleolus

27291:SPAR G03900
gene id: 27291:SPAR_G03900
uniprot id: A0A8B8URV6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the squalene monooxygenase family.
messages: Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Microsome membrane

27291:SPAR G01210
gene id: 27291:SPAR_G01210
uniprot id: A0A8B8UR74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 31 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

27291:SPAR I01330
gene id: 27291:SPAR_I01330
uniprot id: A0A8B8UTG7
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR O01170
gene id: 27291:SPAR_O01170
uniprot id: A0A8B8UZH9
names: Similarity
messages: Belongs to the OPI10 family.

27291:SPAR G02080
gene id: 27291:SPAR_G02080
uniprot id: A0A8B8URC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 63 family.
messages: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
messages: Endoplasmic reticulum membrane

27291:SPAR C00230
gene id: 27291:SPAR_C00230
uniprot id: A0A8B8UM87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR J00430
gene id: 27291:SPAR_J00430
uniprot id: A0A8B8UTS1
names: Similarity
messages: Belongs to the peptidase M20A family.

27291:SPAR N00680
gene id: 27291:SPAR_N00680
uniprot id: A0A8B8UY54
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR O02490
gene id: 27291:SPAR_O02490
uniprot id: A0A8B8UZV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

27291:SPAR J01340
gene id: 27291:SPAR_J01340
uniprot id: A0A8B8UTY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat UTP18 family.
messages: nucleolus

27291:SPAR P00390
gene id: 27291:SPAR_P00390
uniprot id: A0A8B8V0P3
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

27291:SPAR K00140
gene id: 27291:SPAR_K00140
uniprot id: A0A8B8UUI4
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

27291:SPAR C00790
gene id: 27291:SPAR_C00790
uniprot id: A0A8B8UMT5
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR D01220
gene id: 27291:SPAR_D01220
uniprot id: A0A8B8UMZ6
names: Similarity
messages: Belongs to the IWR1/SLC7A6OS family.

27291:SPAR P01050
gene id: 27291:SPAR_P01050
uniprot id: A0A8B8V0R7
names: Similarity
messages: Belongs to the NXF family.

27291:SPAR P00550
gene id: 27291:SPAR_P00550
uniprot id: A0A8B8V0L6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor potential (TRP) ion channel family.
messages: Membrane

27291:SPAR J02480
gene id: 27291:SPAR_J02480
uniprot id: A0A8B8UUD1
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.

27291:SPAR M02580
gene id: 27291:SPAR_M02580
uniprot id: A0A8B8UXE9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL13 family.

27291:SPAR N00300
gene id: 27291:SPAR_N00300
uniprot id: A0A8B8UY70
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

27291:SPAR J01720
gene id: 27291:SPAR_J01720
uniprot id: A0A8B8UU12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRN7/TAF1B family.
messages: nucleolus

27291:SPAR N01850
gene id: 27291:SPAR_N01850
uniprot id: A0A8B8UYH7
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

27291:SPAR K01910
gene id: 27291:SPAR_K01910
uniprot id: A0A8B8UV65
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR J02930
gene id: 27291:SPAR_J02930
uniprot id: A0A8B8UUH6
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

27291:SPAR G01070
gene id: 27291:SPAR_G01070
uniprot id: A0A8B8UR57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR K00300
gene id: 27291:SPAR_K00300
uniprot id: A0A8B8UUK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Cytoplasm
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.

27291:SPAR K00110
gene id: 27291:SPAR_K00110
uniprot id: A0A8B8UUN2
names: Subcellular Location Annotation
messages: Cytoplasm

27291:SPAR P01370
gene id: 27291:SPAR_P01370
uniprot id: A0A8B8V0U1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR D02240
gene id: 27291:SPAR_D02240
uniprot id: A0A8B8UNB7
names: Similarity
messages: Belongs to the glycosyl hydrolase 37 family.

27291:SPAR J01830
gene id: 27291:SPAR_J01830
uniprot id: A0A8B8UU57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm
messages: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.

27291:SPAR I01260
gene id: 27291:SPAR_I01260
uniprot id: A0A8B8UTI2
names: Similarity
names: Subunit
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.

27291:SPAR E00410
gene id: 27291:SPAR_E00410
uniprot id: A0A8B8UPU0
names: Similarity
messages: Belongs to the heat shock protein 70 family.

27291:SPAR C00610
gene id: 27291:SPAR_C00610
uniprot id: A0A8B8UMF5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

27291:SPAR O03800
gene id: 27291:SPAR_O03800
uniprot id: A0A8B8V045
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: cytoskeleton

27291:SPAR K01690
gene id: 27291:SPAR_K01690
uniprot id: A0A8B8UUY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SPC42 family.
messages: Component of the SPC110 complex containing at least CMD1, SPC29, SPC42 and SCP110.
messages: Forms a polymeric layer at the periphery of the spindle pole body (SPB) central plaque which has an essential function during SPB duplication and may facilitate attachment of the SPB to the nuclear membrane.
messages: spindle pole body

27291:SPAR N03220
gene id: 27291:SPAR_N03220
uniprot id: A0A8B8UYV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M76 family.
messages: Has a dual role in the assembly of mitochondrial ATPase.
messages: Mitochondrion inner membrane

27291:SPAR G01180
gene id: 27291:SPAR_G01180
uniprot id: A0A8B8UR24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic GTase family.
messages: Heterodimer.
messages: Nucleus
messages: Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.

27291:SPAR J01930
gene id: 27291:SPAR_J01930
uniprot id: A0A8B8UU67
names: Subcellular Location Annotation
messages: Membrane
messages: cell wall

27291:SPAR L00620
gene id: 27291:SPAR_L00620
uniprot id: A0A8B8UVN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTF2H2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.
messages: Nucleus

27291:SPAR G04660
gene id: 27291:SPAR_G04660
uniprot id: A0A8B8US70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

27291:SPAR K02540
gene id: 27291:SPAR_K02540
uniprot id: A0A8B8UV73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Membrane

27291:SPAR I00360
gene id: 27291:SPAR_I00360
uniprot id: A0A8B8UT90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR H00900
gene id: 27291:SPAR_H00900
uniprot id: A0A8B8USK3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

27291:SPAR D04350
gene id: 27291:SPAR_D04350
uniprot id: A0A8B8UNX6
names: Similarity
messages: Belongs to the universal ribosomal protein uL5 family.

27291:SPAR M04050
gene id: 27291:SPAR_M04050
uniprot id: A0A8B8UXV3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

27291:SPAR D02650
gene id: 27291:SPAR_D02650
uniprot id: A0A8B8UNF8
names: Similarity
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Homodimer.

27291:SPAR P02570
gene id: 27291:SPAR_P02570
uniprot id: A0A8B8V164
names: Similarity
messages: Belongs to the patched family.

27291:SPAR O01610
gene id: 27291:SPAR_O01610
uniprot id: A0A8B8UZH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

27291:SPAR O03160
gene id: 27291:SPAR_O03160
uniprot id: A0A8B8UZY3
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

27291:SPAR K01470
gene id: 27291:SPAR_K01470
uniprot id: A0A8B8UUW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

27291:SPAR L01380
gene id: 27291:SPAR_L01380
uniprot id: A0A8B8UVR6
names: Similarity
messages: Belongs to the actin family.

27291:SPAR F00780
gene id: 27291:SPAR_F00780
uniprot id: A0A8B8UQM8
names: Similarity
messages: Belongs to the peptidase M28 family.

27291:SPAR L03690
gene id: 27291:SPAR_L03690
uniprot id: A0A8B8UWI8
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR P02290
gene id: 27291:SPAR_P02290
uniprot id: A0A8B8V177
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.
messages: Cell membrane
messages: The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.

27291:SPAR L02200
gene id: 27291:SPAR_L02200
uniprot id: A0A8B8UVZ8
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.

27291:SPAR N01470
gene id: 27291:SPAR_N01470
uniprot id: A0A8B8UYH9
names: Similarity
messages: Belongs to the APC1 family.

27291:SPAR C00860
gene id: 27291:SPAR_C00860
uniprot id: A0A8B8UMI2
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

27291:SPAR C01110
gene id: 27291:SPAR_C01110
uniprot id: A0A8B8UMK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

27291:SPAR C00660
gene id: 27291:SPAR_C00660
uniprot id: A0A8B8UMG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

27291:SPAR D02340
gene id: 27291:SPAR_D02340
uniprot id: A0A8B8UNC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS1/PSF1 family.
messages: Component of the GINS complex.
messages: Nucleus
messages: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.

27291:SPAR P02510
gene id: 27291:SPAR_P02510
uniprot id: A0A8B8V193
names: Similarity
messages: Belongs to the RRP12 family.

27291:SPAR J00310
gene id: 27291:SPAR_J00310
uniprot id: A0A8B8UTS7
names: Similarity
messages: Belongs to the MNN1/MNT family.

27291:SPAR H02390
gene id: 27291:SPAR_H02390
uniprot id: A0A8B8UT38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM18/AIM46 family.
messages: Mitochondrion

27291:SPAR O01300
gene id: 27291:SPAR_O01300
uniprot id: A0A8B8UZD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

27291:SPAR J00690
gene id: 27291:SPAR_J00690
uniprot id: A0A8B8UTS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.
messages: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR E01680
gene id: 27291:SPAR_E01680
uniprot id: A0A8B8UQF7
names: Similarity
messages: Belongs to the anthranilate synthase component I family.

27291:SPAR J01700
gene id: 27291:SPAR_J01700
uniprot id: A0A8B8UU06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS53 family.
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

27291:SPAR L01060
gene id: 27291:SPAR_L01060
uniprot id: A0A8B8UVN3
names: Subcellular Location Annotation
messages: nucleolus

27291:SPAR B02030
gene id: 27291:SPAR_B02030
uniprot id: A0A8B8UM26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EXO84 family.
messages: Vesicle
messages: secretory vesicle

27291:SPAR H00110
gene id: 27291:SPAR_H00110
uniprot id: A0A8B8USB6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR1 family.
messages: Component of several multiprotein Golgi SNARE complexes.
messages: Golgi apparatus membrane
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.
messages: Membrane

27291:SPAR K01250
gene id: 27291:SPAR_K01250
uniprot id: A0A8B8UUV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c-type heme lyase family.
messages: Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR O00190
gene id: 27291:SPAR_O00190
uniprot id: A0A8B8UZ77
names: Function
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.
messages: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.

27291:SPAR B00080
gene id: 27291:SPAR_B00080
uniprot id: A0A8B8ULI5
names: Similarity
messages: Belongs to the WD repeat L(2)GL family.

27291:SPAR N02400
gene id: 27291:SPAR_N02400
uniprot id: A0A8B8UYM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

27291:SPAR K00630
gene id: 27291:SPAR_K00630
uniprot id: A0A8B8UUT7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

27291:SPAR M01640
gene id: 27291:SPAR_M01640
uniprot id: A0A8B8UXB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

27291:SPAR J02110
gene id: 27291:SPAR_J02110
uniprot id: A0A8B8UUA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

27291:SPAR L04080
gene id: 27291:SPAR_L04080
uniprot id: A0A8B8UWJ2
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR C00540
gene id: 27291:SPAR_C00540
uniprot id: A0A8B8UMR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane

27291:SPAR I01290
gene id: 27291:SPAR_I01290
uniprot id: A0A8B8UTE1
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR O04460
gene id: 27291:SPAR_O04460
uniprot id: A0A8B8V0A7
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

27291:SPAR D03450
gene id: 27291:SPAR_D03450
uniprot id: A0A8B8UNN8
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR L02025
gene id: 27291:SPAR_L02025
uniprot id: A0A8B8UVX9
names: Similarity
messages: Belongs to the peptidase M16 family.

27291:SPAR O00350
gene id: 27291:SPAR_O00350
uniprot id: A0A8B8UZ44
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS19 family.

27291:SPAR J02850
gene id: 27291:SPAR_J02850
uniprot id: A0A8B8UUC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Membrane

27291:SPAR D04590
gene id: 27291:SPAR_D04590
uniprot id: A0A8B8UNZ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
messages: Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Nucleus

27291:SPAR P02210
gene id: 27291:SPAR_P02210
uniprot id: A0A8B8V163
names: Function
names: Similarity
messages: Belongs to the VPS16 family.
messages: Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.

27291:SPAR D01370
gene id: 27291:SPAR_D01370
uniprot id: A0A8B8UN11
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1 and GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-GET2 receptor, and returning it to the cytosol to initiate a new round of targeting. Cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in low-level resistance to the oxyanions arsenite and arsenate, and in heat tolerance.
messages: Belongs to the arsA ATPase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer. Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer. Interacts with the chloride channel protein GEF1.

27291:SPAR O02780
gene id: 27291:SPAR_O02780
uniprot id: A0A8B8UZU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR D00500
gene id: 27291:SPAR_D00500
uniprot id: A0A8B8UMT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC31 family.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR I01920
gene id: 27291:SPAR_I01920
uniprot id: A0A8B8UTH4
names: Similarity
messages: Belongs to the glutathione peroxidase family.

27291:SPAR K00860
gene id: 27291:SPAR_K00860
uniprot id: A0A8B8UUW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHE2 family.
messages: Homodimer and homotetramer. Interacts with LOC1, MYO4, PUF6, SHE3 and with RNA pol II subunits RPO21, SPT4 and SPT5.
messages: Nucleus
messages: RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell. Recruits the MYO4-SHE3 complex to the ASH1 mRNA. Recruits also LOC1 and PUF6 to ASH1 mRNA, which are required for translational repression of this mRNA.

27291:SPAR P04030
gene id: 27291:SPAR_P04030
uniprot id: A0A8B8V1K6
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

27291:SPAR D03900
gene id: 27291:SPAR_D03900
uniprot id: A0A8B8UNT0
names: Similarity
messages: Belongs to the phosducin family.

27291:SPAR J00180
gene id: 27291:SPAR_J00180
uniprot id: A0A8B8UTP9
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR G04570
gene id: 27291:SPAR_G04570
uniprot id: A0A8B8US58
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.

27291:SPAR K00690
gene id: 27291:SPAR_K00690
uniprot id: A0A8B8UUN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lariat debranching enzyme family.
messages: Nucleus

27291:SPAR C00900
gene id: 27291:SPAR_C00900
uniprot id: A0A8B8UMJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

27291:SPAR D04080
gene id: 27291:SPAR_D04080
uniprot id: A0A8B8UP62
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Endoplasmic reticulum membrane
messages: Functions as a zinc transporter.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

27291:SPAR M01370
gene id: 27291:SPAR_M01370
uniprot id: A0A8B8UX26
names: Similarity
messages: Belongs to the polyprenol kinase family.

27291:SPAR G00310
gene id: 27291:SPAR_G00310
uniprot id: A0A8B8UQY3
names: Similarity
messages: Belongs to the SAPS family.

27291:SPAR D02520
gene id: 27291:SPAR_D02520
uniprot id: A0A8B8UNC5
names: Similarity
messages: Belongs to the WrbA family.

27291:SPAR N01530
gene id: 27291:SPAR_N01530
uniprot id: A0A8B8UYE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IBD2 family.
messages: spindle pole

27291:SPAR G01700
gene id: 27291:SPAR_G01700
uniprot id: A0A8B8UR86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

27291:SPAR B00800
gene id: 27291:SPAR_B00800
uniprot id: A0A8B8ULE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: Nucleus

27291:SPAR L00490
gene id: 27291:SPAR_L00490
uniprot id: A0A8B8UVH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX17 family.
messages: Mitochondrion intermembrane space

27291:SPAR A00440
gene id: 27291:SPAR_A00440
uniprot id: A0A8B8UKY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

27291:SPAR B00410
gene id: 27291:SPAR_B00410
uniprot id: A0A8B8UL91
names: Similarity
messages: Belongs to the peptidase C19 family.

27291:SPAR D05020
gene id: 27291:SPAR_D05020
uniprot id: A0A8B8UP25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB1 family.
messages: Nucleus

27291:SPAR M00450
gene id: 27291:SPAR_M00450
uniprot id: A0A8B8UWT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxygen-dependent FAD-linked oxidoreductase family.
messages: Mitochondrion membrane

27291:SPAR K00650
gene id: 27291:SPAR_K00650
uniprot id: A0A8B8UUP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP receptor beta subunit family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR L02730
gene id: 27291:SPAR_L02730
uniprot id: A0A8B8UW54
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

27291:SPAR E00270
gene id: 27291:SPAR_E00270
uniprot id: A0A8B8UPR5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Binds 1 FAD per monomer.
messages: Irreversibly catalyzes the reduction of fumarate to succinate.

27291:SPAR P02530
gene id: 27291:SPAR_P02530
uniprot id: A0A8B8V157
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

27291:SPAR P04050
gene id: 27291:SPAR_P04050
uniprot id: A0A8B8V1L9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC4 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication.
messages: Nucleus

27291:SPAR A00580
gene id: 27291:SPAR_A00580
uniprot id: A0A8B8ULF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

27291:SPAR H00470
gene id: 27291:SPAR_H00470
uniprot id: A0A8B8USB1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

27291:SPAR L01590
gene id: 27291:SPAR_L01590
uniprot id: A0A8B8UVT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the midasin family.
messages: Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.
messages: nucleolus
messages: nucleoplasm

27291:SPAR G00220
gene id: 27291:SPAR_G00220
uniprot id: A0A8B8UQX1
names: Similarity
messages: Belongs to the APC10 family.

27291:SPAR D06260
gene id: 27291:SPAR_D06260
uniprot id: A0A8B8UPH3
names: Similarity
messages: Belongs to the putative lipase ROG1 family.

27291:SPAR L00910
gene id: 27291:SPAR_L00910
uniprot id: A0A8B8UVL8
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

27291:SPAR E01010
gene id: 27291:SPAR_E01010
uniprot id: A0A8B8UQ03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CHZ1 family.
messages: Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.
messages: Nucleus

27291:SPAR L04120
gene id: 27291:SPAR_L04120
uniprot id: A0A8B8UWQ4
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

27291:SPAR N03570
gene id: 27291:SPAR_N03570
uniprot id: A0A8B8UYZ3
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR H02500
gene id: 27291:SPAR_H02500
uniprot id: A0A8B8USY3
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

27291:SPAR N01750
gene id: 27291:SPAR_N01750
uniprot id: A0A8B8UYL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC2 family.
messages: Nucleus

27291:SPAR D01110
gene id: 27291:SPAR_D01110
uniprot id: A0A8B8UN05
names: Similarity
messages: Belongs to the cyclin family.

27291:SPAR L04510
gene id: 27291:SPAR_L04510
uniprot id: A0A8B8UWN2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

27291:SPAR H01060
gene id: 27291:SPAR_H01060
uniprot id: A0A8B8USL0
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.

27291:SPAR L03930
gene id: 27291:SPAR_L03930
uniprot id: A0A8B8UWH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP1/IKA1 family.
messages: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
messages: Cytoplasm
messages: Nucleus

27291:SPAR N02590
gene id: 27291:SPAR_N02590
uniprot id: A0A8B8UYP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum.

27291:SPAR C01000
gene id: 27291:SPAR_C01000
uniprot id: A0A8B8UMK3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.

27291:SPAR D01900
gene id: 27291:SPAR_D01900
uniprot id: A0A8B8UN82
names: Similarity
messages: Belongs to the SF3A2 family.

27291:SPAR G03320
gene id: 27291:SPAR_G03320
uniprot id: A0A8B8URT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF1 family.
messages: Mitochondrion inner membrane
messages: Probably involved in the biogenesis of the COX complex.

27291:SPAR H01450
gene id: 27291:SPAR_H01450
uniprot id: A0A8B8USR3
names: Subcellular Location Annotation
messages: Golgi apparatus

27291:SPAR B03620
gene id: 27291:SPAR_B03620
uniprot id: A0A8B8UM33
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR D05540
gene id: 27291:SPAR_D05540
uniprot id: A0A8B8UP88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF1 family.
messages: nucleolus

27291:SPAR E01320
gene id: 27291:SPAR_E01320
uniprot id: A0A8B8UQ19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PET117 family.
messages: Mitochondrion

27291:SPAR H00980
gene id: 27291:SPAR_H00980
uniprot id: A0A8B8USP9
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

27291:SPAR M03030
gene id: 27291:SPAR_M03030
uniprot id: A0A8B8UXJ7
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

27291:SPAR C00780
gene id: 27291:SPAR_C00780
uniprot id: A0A8B8UME8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal/bacterial/fungal opsin family.
messages: Membrane

27291:SPAR O01990
gene id: 27291:SPAR_O01990
uniprot id: A0A8B8UZQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLD7 family.
messages: Interacts with SLD3.
messages: Nucleus
messages: Required for the proper function of SLD3 at the initiation of DNA replication. Binds to SLD3 and reduces its affinity for CDC45, a component of the replication fork. Required for mitochondrial morphology.
messages: Required for the proper initiation of DNA replication. Required for mitochondrial morphology.
messages: spindle pole

27291:SPAR M01780
gene id: 27291:SPAR_M01780
uniprot id: A0A8B8UX67
names: Similarity
messages: Belongs to the SEN15 family.

27291:SPAR O01020
gene id: 27291:SPAR_O01020
uniprot id: A0A8B8UZG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 15 family.
messages: Nucleus

27291:SPAR B00700
gene id: 27291:SPAR_B00700
uniprot id: A0A8B8ULC6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.
messages: Belongs to the DNA polymerase alpha subunit B family.
messages: Nucleus

27291:SPAR L02410
gene id: 27291:SPAR_L02410
uniprot id: A0A8B8UW20
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

27291:SPAR J02220
gene id: 27291:SPAR_J02220
uniprot id: A0A8B8UU58
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR K00740
gene id: 27291:SPAR_K00740
uniprot id: A0A8B8UUP3
names: Similarity
messages: Belongs to the LTV1 family.

27291:SPAR M00960
gene id: 27291:SPAR_M00960
uniprot id: A0A8B8UX38
names: Similarity
messages: Belongs to the RAD52 family.

27291:SPAR D04790
gene id: 27291:SPAR_D04790
uniprot id: A0A8B8UP16
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

27291:SPAR J00620
gene id: 27291:SPAR_J00620
uniprot id: A0A8B8UTP0
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

27291:SPAR G04260
gene id: 27291:SPAR_G04260
uniprot id: A0A8B8US29
names: Similarity
messages: Belongs to the lipid-translocating exporter (LTE) (TC 9.A.26.1) family.

27291:SPAR D02460
gene id: 27291:SPAR_D02460
uniprot id: A0A8B8UND6
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

27291:SPAR L00800
gene id: 27291:SPAR_L00800
uniprot id: A0A8B8UVR4
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR L01580
gene id: 27291:SPAR_L01580
uniprot id: A0A8B8UVT6
names: Function
names: Similarity
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.

27291:SPAR D01640
gene id: 27291:SPAR_D01640
uniprot id: A0A8B8UN58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

27291:SPAR D05900
gene id: 27291:SPAR_D05900
uniprot id: A0A8B8UPD8
names: Similarity
messages: Belongs to the cytochrome P450 family.

27291:SPAR J02000
gene id: 27291:SPAR_J02000
uniprot id: A0A8B8UU44
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sulfate adenylyltransferase family.
messages: Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.
messages: Cytoplasm
messages: Homohexamer. Dimer of trimers.
messages: The oligomerization domain is distantly related to APS kinases, but it is not functional and does not bind APS. It is required for oligomerization of the enzyme, although the oligomerization state has no effect on the catalytic activity of the enzyme.

27291:SPAR D06700
gene id: 27291:SPAR_D06700
uniprot id: A0A8B8UPK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool.
messages: Belongs to the complex I LYR family. MZM1 subfamily.
messages: Interacts with RIP1.
messages: Mitochondrion matrix

27291:SPAR J02530
gene id: 27291:SPAR_J02530
uniprot id: A0A8B8UUD8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II.
messages: Cytoplasm
messages: Nucleus
messages: Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.

27291:SPAR J03030
gene id: 27291:SPAR_J03030
uniprot id: A0A8B8UUI7
names: Similarity
messages: Belongs to the peptidase M28 family. M28B subfamily.

27291:SPAR N00670
gene id: 27291:SPAR_N00670
uniprot id: A0A8B8UY98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: DNA polymerase II participates in chromosomal DNA replication.
messages: Nucleus

27291:SPAR B03790
gene id: 27291:SPAR_B03790
uniprot id: A0A8B8UM88
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

27291:SPAR P01220
gene id: 27291:SPAR_P01220
uniprot id: A0A8B8V0S6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the WD repeat PRL1/PRL2 family.
messages: Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.
messages: Nucleus

27291:SPAR J02470
gene id: 27291:SPAR_J02470
uniprot id: A0A8B8UU83
names: Similarity
messages: Belongs to the actin family.

27291:SPAR J01230
gene id: 27291:SPAR_J01230
uniprot id: A0A8B8UTZ5
names: Similarity
messages: Belongs to the IML2 family.

27291:SPAR O03250
gene id: 27291:SPAR_O03250
uniprot id: A0A8B8UZZ2
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

27291:SPAR G05040
gene id: 27291:SPAR_G05040
uniprot id: A0A8B8UML1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

27291:SPAR P04340
gene id: 27291:SPAR_P04340
uniprot id: A0A8B8V1X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR J00390
gene id: 27291:SPAR_J00390
uniprot id: A0A8B8UTP4
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

27291:SPAR J00200
gene id: 27291:SPAR_J00200
uniprot id: A0A8B8UTJ7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Mitochondrion

27291:SPAR M01760
gene id: 27291:SPAR_M01760
uniprot id: A0A8B8UXB0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Catalyzes the exchange of ADP and ATP across the membrane.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Monomer.

27291:SPAR F00990
gene id: 27291:SPAR_F00990
uniprot id: A0A8B8UQT3
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR L01990
gene id: 27291:SPAR_L01990
uniprot id: A0A8B8UVX3
names: Similarity
messages: Belongs to the Nudix hydrolase family. PCD1 subfamily.

27291:SPAR P01420
gene id: 27291:SPAR_P01420
uniprot id: A0A8B8V0U7
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR P01890
gene id: 27291:SPAR_P01890
uniprot id: A0A8B8V141
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

27291:SPAR E00190
gene id: 27291:SPAR_E00190
uniprot id: A0A8B8UPR6
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR P00990
gene id: 27291:SPAR_P00990
uniprot id: A0A8B8V0V3
names: Function
messages: Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

27291:SPAR D04520
gene id: 27291:SPAR_D04520
uniprot id: A0A8B8UNX4
names: Function
names: Similarity
messages: Belongs to the catalase family.
messages: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.

27291:SPAR N03030
gene id: 27291:SPAR_N03030
uniprot id: A0A8B8UYY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290). In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.
messages: Cytoplasm

27291:SPAR J02940
gene id: 27291:SPAR_J02940
uniprot id: A0A8B8UUC9
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR A00220
gene id: 27291:SPAR_A00220
uniprot id: A0A8B8UKM7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

27291:SPAR K00910
gene id: 27291:SPAR_K00910
uniprot id: A0A8B8UUW6
names: Similarity
messages: Belongs to the RRN3 family.

27291:SPAR D00850
gene id: 27291:SPAR_D00850
uniprot id: A0A8B8UMX4
names: Similarity
messages: Belongs to the cyclin family.

27291:SPAR B00690
gene id: 27291:SPAR_B00690
uniprot id: A0A8B8ULB7
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.

27291:SPAR G00640
gene id: 27291:SPAR_G00640
uniprot id: A0A8B8UR80
names: Similarity
messages: Belongs to the MT-A70-like family.

27291:SPAR D04540
gene id: 27291:SPAR_D04540
uniprot id: A0A8B8UNZ2
names: Similarity
messages: Belongs to the ClpA/ClpB family.

27291:SPAR O04330
gene id: 27291:SPAR_O04330
uniprot id: A0A8B8V095
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

27291:SPAR C00530
gene id: 27291:SPAR_C00530
uniprot id: A0A8B8UMC5
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.

27291:SPAR N01670
gene id: 27291:SPAR_N01670
uniprot id: A0A8B8UYJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

27291:SPAR I00060
gene id: 27291:SPAR_I00060
uniprot id: A0A8B8UT62
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR K00150
gene id: 27291:SPAR_K00150
uniprot id: A0A8B8UUJ0
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR H01110
gene id: 27291:SPAR_H01110
uniprot id: A0A8B8USL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRM5 / TYW2 family.
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.
messages: Cytoplasm
messages: Mitochondrion matrix
messages: Monomer.
messages: Nucleus
messages: Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. Postspliced cytoplasmic tRNAs are imported into the nucleus, where this first step seems to take place, after which they are reexported to the cytoplasm, where the yW sythesis is completed by cytoplasmic enzymes.

27291:SPAR B03580
gene id: 27291:SPAR_B03580
uniprot id: A0A8B8UMH4
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

27291:SPAR P02910
gene id: 27291:SPAR_P02910
uniprot id: A0A8B8V1D4
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

27291:SPAR M03240
gene id: 27291:SPAR_M03240
uniprot id: A0A8B8UXS4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Cytoplasm
messages: Mevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway. The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins.

27291:SPAR M02570
gene id: 27291:SPAR_M02570
uniprot id: A0A8B8UXE5
names: Similarity
messages: Belongs to the SIP5 family.

27291:SPAR B03770
gene id: 27291:SPAR_B03770
uniprot id: A0A8B8UM47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL41 family.
messages: Mitochondrion

27291:SPAR B00870
gene id: 27291:SPAR_B00870
uniprot id: A0A8B8UL99
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

27291:SPAR D01860
gene id: 27291:SPAR_D01860
uniprot id: A0A8B8UN76
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NPC2 family.
messages: Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
messages: Monomer.

27291:SPAR B02330
gene id: 27291:SPAR_B02330
uniprot id: A0A8B8UM54
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily.

27291:SPAR I01490
gene id: 27291:SPAR_I01490
uniprot id: A0A8B8UTG1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
messages: Belongs to the URM1 family.
messages: C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.
messages: Cytoplasm
messages: Homodimer; homodimerization may provide an autoprotection to the highly active C-terminal residue before attacking its substrates. Interacts with NCS2 and NCS6. Forms a conjugate with the target protein AHP1.
messages: Nucleus

27291:SPAR P03740
gene id: 27291:SPAR_P03740
uniprot id: A0A8B8V1N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Peroxisome membrane

27291:SPAR G01120
gene id: 27291:SPAR_G01120
uniprot id: A0A8B8UR61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat COPB2 family.
messages: COPI-coated vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

27291:SPAR G02890
gene id: 27291:SPAR_G02890
uniprot id: A0A8B8URV7
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR D04690
gene id: 27291:SPAR_D04690
uniprot id: A0A8B8UP06
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

27291:SPAR M00310
gene id: 27291:SPAR_M00310
uniprot id: A0A8B8UWW9
names: Subcellular Location Annotation
messages: nuclear pore complex

27291:SPAR G03850
gene id: 27291:SPAR_G03850
uniprot id: A0A8B8URU9
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. Interacts with pstB2. This interaction may be a means to structurally tether the donor membrane (ER) harboring PstB2 to acceptor membranes (Golgi/endosomes) harboring PSD2 during PtdSer transport to the site of PtdEtn synthesis.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
messages: The C2 domains have an essential, but non-catalytic function. They may facilitate interaction with PstB2 and are required for lipid transport function.

27291:SPAR F00900
gene id: 27291:SPAR_F00900
uniprot id: A0A8B8UQS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC2 subfamily.
messages: Nucleus

27291:SPAR G01160
gene id: 27291:SPAR_G01160
uniprot id: A0A8B8UR68
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR F00390
gene id: 27291:SPAR_F00390
uniprot id: A0A8B8UQM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.
messages: Nucleus

27291:SPAR L00210
gene id: 27291:SPAR_L00210
uniprot id: A0A8B8UVE5
names: Function
names: Similarity
messages: Belongs to the VPS13 family.
messages: Mediates the transfer of lipids between membranes at organelle contact sites. May play a role in mitochondrial lipid homeostasis.

27291:SPAR B00400
gene id: 27291:SPAR_B00400
uniprot id: A0A8B8ULA0
names: Function
names: Similarity
messages: 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

27291:SPAR F01130
gene id: 27291:SPAR_F01130
uniprot id: A0A8B8UQR2
names: Similarity
messages: Belongs to the proteasome subunit S14 family.

27291:SPAR G01230
gene id: 27291:SPAR_G01230
uniprot id: A0A8B8UR30
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

27291:SPAR G03990
gene id: 27291:SPAR_G03990
uniprot id: A0A8B8US61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIF alpha subunit family.
messages: Nucleus
messages: TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.

27291:SPAR F00290
gene id: 27291:SPAR_F00290
uniprot id: A0A8B8UQL2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

27291:SPAR P00130
gene id: 27291:SPAR_P00130
uniprot id: A0A8B8V0G4
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.

27291:SPAR P02630
gene id: 27291:SPAR_P02630
uniprot id: A0A8B8V167
names: Similarity
messages: Belongs to the citrate synthase family.

27291:SPAR J02590
gene id: 27291:SPAR_J02590
uniprot id: A0A8B8UU97
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

27291:SPAR M01310
gene id: 27291:SPAR_M01310
uniprot id: A0A8B8UX74
names: Similarity
messages: Belongs to the lysophospholipase family.

27291:SPAR G04000
gene id: 27291:SPAR_G04000
uniprot id: A0A8B8URW3
names: Similarity
messages: Belongs to the HGH1 family.

27291:SPAR H00390
gene id: 27291:SPAR_H00390
uniprot id: A0A8B8USC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Endosome membrane
messages: Membrane

27291:SPAR L02190
gene id: 27291:SPAR_L02190
uniprot id: A0A8B8UW46
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL37 family.
messages: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.

27291:SPAR O03550
gene id: 27291:SPAR_O03550
uniprot id: A0A8B8V024
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

27291:SPAR D06420
gene id: 27291:SPAR_D06420
uniprot id: A0A8B8UPH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL40 family.
messages: Mitochondrion

27291:SPAR G02880
gene id: 27291:SPAR_G02880
uniprot id: Q0P6S9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPT4 family.
messages: Nucleus
messages: The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.
messages: centromere

27291:SPAR B03640
gene id: 27291:SPAR_B03640
uniprot id: A0A8B8UM74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL54 family.
messages: Mitochondrion

27291:SPAR P02360
gene id: 27291:SPAR_P02360
uniprot id: A0A8B8V178
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

27291:SPAR A00650
gene id: 27291:SPAR_A00650
uniprot id: A0A8B8UL27
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR B03320
gene id: 27291:SPAR_B03320
uniprot id: A0A8B8UM01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
messages: In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.
messages: Nucleus
messages: Responsible for methylating the 5'-cap structure of mRNAs.

27291:SPAR E02390
gene id: 27291:SPAR_E02390
uniprot id: A0A8B8UQD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

27291:SPAR N00870
gene id: 27291:SPAR_N00870
uniprot id: A0A8B8UYC2
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.

27291:SPAR J02950
gene id: 27291:SPAR_J02950
uniprot id: A0A8B8UUD7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48A family.
messages: Binds 1 zinc ion per subunit.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Proteolytically removes the C-terminal three residues of farnesylated proteins.

27291:SPAR O03750
gene id: 27291:SPAR_O03750
uniprot id: A0A8B8V040
names: Similarity
messages: Belongs to the AAA ATPase family.

27291:SPAR D02640
gene id: 27291:SPAR_D02640
uniprot id: A0A8B8UNF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

27291:SPAR N03210
gene id: 27291:SPAR_N03210
uniprot id: A0A8B8UZ11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Sterol O-acyltransferase that catalyzes the formation of stery esters.

27291:SPAR D05490
gene id: 27291:SPAR_D05490
uniprot id: A0A8B8UP84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCP1 family.
messages: Involved in nuclear export, actin cytoskeleton organization and vesicular transport.
messages: Nucleus

27291:SPAR B02540
gene id: 27291:SPAR_B02540
uniprot id: A0A8B8ULW2
names: Similarity
messages: Belongs to the TTC4 family.

27291:SPAR E01840
gene id: 27291:SPAR_E01840
uniprot id: A0A8B8UQ84
names: Similarity
messages: Belongs to the non-repetitive/WGA-negative nucleoporin family.

27291:SPAR H02350
gene id: 27291:SPAR_H02350
uniprot id: A0A8B8USW9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM31/MDM32 family.
messages: Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR M01050
gene id: 27291:SPAR_M01050
uniprot id: A0A8B8UX01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

27291:SPAR K02150
gene id: 27291:SPAR_K02150
uniprot id: A0A8B8UV44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Mitochondrion

27291:SPAR J01400
gene id: 27291:SPAR_J01400
uniprot id: A0A8B8UTX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
messages: Endoplasmic reticulum membrane
messages: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.
messages: Membrane

27291:SPAR K01840
gene id: 27291:SPAR_K01840
uniprot id: A0A8B8UV03
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

27291:SPAR B03850
gene id: 27291:SPAR_B03850
uniprot id: A0A8B8UM89
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR L01240
gene id: 27291:SPAR_L01240
uniprot id: A0A8B8UVQ2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Mitochondrion
messages: The precursor is processed in two steps involving mitochondrial intermediate peptidase (MIP) and mitochondrial processing peptidase (MPP).

27291:SPAR L00180
gene id: 27291:SPAR_L00180
uniprot id: A0A8B8UVE3
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR O02480
gene id: 27291:SPAR_O02480
uniprot id: A0A8B8UZR3
names: Similarity
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.

27291:SPAR K00620
gene id: 27291:SPAR_K00620
uniprot id: A0A8B8UUN3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

27291:SPAR H00250
gene id: 27291:SPAR_H00250
uniprot id: A0A8B8USD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LU7TM family.
messages: Membrane

27291:SPAR I01530
gene id: 27291:SPAR_I01530
uniprot id: A0A8B8UTI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export.
messages: Cytoplasm

27291:SPAR H02110
gene id: 27291:SPAR_H02110
uniprot id: A0A8B8USX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.
messages: Belongs to the NMD3 family.
messages: Cytoplasm
messages: Nucleus

27291:SPAR D02080
gene id: 27291:SPAR_D02080
uniprot id: A0A8B8UNK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

27291:SPAR J01190
gene id: 27291:SPAR_J01190
uniprot id: A0A8B8UTW8
names: Similarity
messages: Belongs to the TRL1 family.

27291:SPAR O02420
gene id: 27291:SPAR_O02420
uniprot id: A0A8B8UZV2
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

27291:SPAR D00510
gene id: 27291:SPAR_D00510
uniprot id: A0A8B8UMU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR L03000
gene id: 27291:SPAR_L03000
uniprot id: A0A8B8UW79
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

27291:SPAR O03380
gene id: 27291:SPAR_O03380
uniprot id: A0A8B8V003
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIM41 family.
messages: Mitochondrion

27291:SPAR L00840
gene id: 27291:SPAR_L00840
uniprot id: A0A8B8UVL3
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

27291:SPAR H01860
gene id: 27291:SPAR_H01860
uniprot id: A0A8B8USV0
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

27291:SPAR J03120
gene id: 27291:SPAR_J03120
uniprot id: A0A8B8UUE4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

27291:SPAR D03720
gene id: 27291:SPAR_D03720
uniprot id: A0A8B8UNP8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SEC5 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
messages: Component of the exocyst complex.

27291:SPAR J01980
gene id: 27291:SPAR_J01980
uniprot id: A0A8B8UU73
names: Similarity
messages: Belongs to the MEMO1 family.

27291:SPAR D05430
gene id: 27291:SPAR_D05430
uniprot id: A0A8B8UPJ2
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

27291:SPAR D00270
gene id: 27291:SPAR_D00270
uniprot id: A0A8B8UMQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DTD family.
messages: Cytoplasm

27291:SPAR D05700
gene id: 27291:SPAR_D05700
uniprot id: A0A8B8UPB8
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.

27291:SPAR F00260
gene id: 27291:SPAR_F00260
uniprot id: A0A8B8UQH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

27291:SPAR E01590
gene id: 27291:SPAR_E01590
uniprot id: A0A8B8UQ59
names: Subcellular Location Annotation
messages: nucleolus

27291:SPAR B00060
gene id: 27291:SPAR_B00060
uniprot id: A0A8B8UL43
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

27291:SPAR J01870
gene id: 27291:SPAR_J01870
uniprot id: A0A8B8UU26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX16 family.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR D04070
gene id: 27291:SPAR_D04070
uniprot id: A0A8B8UNS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ4 family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with COQ3.
messages: Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of COQ3, COQ4, COQ6, COQ7 and COQ9 polypeptides.
messages: Mitochondrion inner membrane

27291:SPAR O04250
gene id: 27291:SPAR_O04250
uniprot id: A0A8B8V088
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR P01750
gene id: 27291:SPAR_P01750
uniprot id: A0A8B8V0Y7
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

27291:SPAR M03150
gene id: 27291:SPAR_M03150
uniprot id: A0A8B8UXL7
names: Function
names: Similarity
messages: Belongs to the cyclin family.
messages: G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition.

27291:SPAR G02360
gene id: 27291:SPAR_G02360
uniprot id: A0A8B8URJ3
names: Subcellular Location Annotation
messages: Membrane
messages: Peroxisome membrane

27291:SPAR P01840
gene id: 27291:SPAR_P01840
uniprot id: A0A8B8V134
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC16 family.
messages: Endoplasmic reticulum membrane
messages: Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.
messages: Membrane

27291:SPAR D03950
gene id: 27291:SPAR_D03950
uniprot id: A0A8B8UNT6
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

27291:SPAR B02870
gene id: 27291:SPAR_B02870
uniprot id: A0A8B8ULV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDT1 family.
messages: Membrane

27291:SPAR C01330
gene id: 27291:SPAR_C01330
uniprot id: A0A8B8UMK5
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR D03300
gene id: 27291:SPAR_D03300
uniprot id: A0A8B8UNM1
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR D02800
gene id: 27291:SPAR_D02800
uniprot id: A0A8B8UNH2
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

27291:SPAR B01190
gene id: 27291:SPAR_B01190
uniprot id: A0A8B8ULG9
names: Similarity
messages: Belongs to the MNN1/MNT family.

27291:SPAR J01150
gene id: 27291:SPAR_J01150
uniprot id: A0A8B8UTU4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGW family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.

27291:SPAR J01800
gene id: 27291:SPAR_J01800
uniprot id: A0A8B8UU19
names: Subcellular Location Annotation
messages: Membrane
messages: Vacuole membrane

27291:SPAR L02900
gene id: 27291:SPAR_L02900
uniprot id: A0A8B8UW70
names: Similarity
messages: Belongs to the XRCC4-XLF family. XLF subfamily.

27291:SPAR B01060
gene id: 27291:SPAR_B01060
uniprot id: A0A8B8ULF7
names: Similarity
messages: Belongs to the UPP synthase family.

27291:SPAR B01470
gene id: 27291:SPAR_B01470
uniprot id: A0A8B8ULG0
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

27291:SPAR D06680
gene id: 27291:SPAR_D06680
uniprot id: A0A8B8UPJ4
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.

27291:SPAR D03130
gene id: 27291:SPAR_D03130
uniprot id: A0A8B8UNX0
names: Similarity
messages: Belongs to the 14-3-3 family.

27291:SPAR I01270
gene id: 27291:SPAR_I01270
uniprot id: A0A8B8UTB0
names: Similarity
messages: Belongs to the peptidase C48 family.

27291:SPAR P00080
gene id: 27291:SPAR_P00080
uniprot id: A0A8B8V0F9
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.

27291:SPAR K02040
gene id: 27291:SPAR_K02040
uniprot id: A0A8B8UV21
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

27291:SPAR L04200
gene id: 27291:SPAR_L04200
uniprot id: A0A8B8UWK0
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR H01610
gene id: 27291:SPAR_H01610
uniprot id: A0A8B8USR9
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.
messages: Chromosome
messages: Component of the COMPASS (Set1C) complex.
messages: Nucleus

27291:SPAR D05670
gene id: 27291:SPAR_D05670
uniprot id: A0A8B8UP94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

27291:SPAR G04210
gene id: 27291:SPAR_G04210
uniprot id: A0A8B8US25
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

27291:SPAR D04650
gene id: 27291:SPAR_D04650
uniprot id: A0A8B8UP07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane

27291:SPAR N03110
gene id: 27291:SPAR_N03110
uniprot id: A0A8B8UZ01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WHI5/NRM1 family.
messages: Cytoplasm
messages: Nucleus

27291:SPAR L00640
gene id: 27291:SPAR_L00640
uniprot id: A0A8B8UVJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.
messages: Belongs to the NSE1 family.
messages: Component of the Smc5-Smc6 complex.
messages: Nucleus

27291:SPAR K00050
gene id: 27291:SPAR_K00050
uniprot id: A0A8B8UUI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferric reductase (FRE) family.
messages: Cell membrane
messages: Membrane

27291:SPAR O01650
gene id: 27291:SPAR_O01650
uniprot id: A0A8B8UZH3
names: Similarity
messages: Belongs to the GroES chaperonin family.

27291:SPAR A00610
gene id: 27291:SPAR_A00610
uniprot id: A0A8B8UL11
names: Similarity
messages: Belongs to the VPS8 family.

27291:SPAR M02300
gene id: 27291:SPAR_M02300
uniprot id: A0A8B8UXD3
names: Similarity
messages: Belongs to the SOS response-associated peptidase family.

27291:SPAR H02570
gene id: 27291:SPAR_H02570
uniprot id: A0A8B8USX0
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

27291:SPAR L03180
gene id: 27291:SPAR_L03180
uniprot id: A0A8B8UWA0
names: Function
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.

27291:SPAR L02980
gene id: 27291:SPAR_L02980
uniprot id: A0A8B8UW82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

27291:SPAR D04250
gene id: 27291:SPAR_D04250
uniprot id: A0A8B8UNW6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Mitochondrion intermembrane space
messages: Monomer.
messages: cytosol

27291:SPAR G04280
gene id: 27291:SPAR_G04280
uniprot id: A0A8B8URY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

27291:SPAR B02810
gene id: 27291:SPAR_B02810
uniprot id: A0A8B8ULX6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

27291:SPAR L01420
gene id: 27291:SPAR_L01420
uniprot id: A0A8B8UVW7
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

27291:SPAR E00980
gene id: 27291:SPAR_E00980
uniprot id: A0A8B8UQ99
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.

27291:SPAR N00430
gene id: 27291:SPAR_N00430
uniprot id: A0A8B8UY28
names: Similarity
messages: Belongs to the activator 1 small subunits family.

27291:SPAR I01100
gene id: 27291:SPAR_I01100
uniprot id: A0A8B8UT85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.

27291:SPAR D01560
gene id: 27291:SPAR_D01560
uniprot id: A0A8B8UN47
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.

27291:SPAR P04240
gene id: 27291:SPAR_P04240
uniprot id: A0A8B8V1W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

27291:SPAR D01350
gene id: 27291:SPAR_D01350
uniprot id: A0A8B8UN28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

27291:SPAR L00920
gene id: 27291:SPAR_L00920
uniprot id: A0A8B8UVR5
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR D03140
gene id: 27291:SPAR_D03140
uniprot id: A0A8B8UNK8
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR D03510
gene id: 27291:SPAR_D03510
uniprot id: A0A8B8UNP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat peroxin-7 family.
messages: Peroxisome matrix
messages: cytosol

27291:SPAR P03280
gene id: 27291:SPAR_P03280
uniprot id: A0A8B8V1D2
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

27291:SPAR K02630
gene id: 27291:SPAR_K02630
uniprot id: A0A8B8UTV3
names: Function
names: Similarity
messages: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.

27291:SPAR O02030
gene id: 27291:SPAR_O02030
uniprot id: A0A8B8UZL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ING family.
messages: Nucleus

27291:SPAR D00960
gene id: 27291:SPAR_D00960
uniprot id: A0A8B8UMY8
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

27291:SPAR J02580
gene id: 27291:SPAR_J02580
uniprot id: A0A8B8UUE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR D05390
gene id: 27291:SPAR_D05390
uniprot id: A0A8B8UP74
names: Similarity
messages: Belongs to the peptidase A1 family.

27291:SPAR E01640
gene id: 27291:SPAR_E01640
uniprot id: A0A8B8UQ64
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

27291:SPAR M00130
gene id: 27291:SPAR_M00130
uniprot id: A0A8B8UWQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Component of the GSE complex.
messages: GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.

27291:SPAR H00090
gene id: 27291:SPAR_H00090
uniprot id: A0A8B8US91
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Component of the ribosome.

27291:SPAR C00240
gene id: 27291:SPAR_C00240
uniprot id: A0A8B8UMN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR1 family.
messages: Membrane

27291:SPAR N01230
gene id: 27291:SPAR_N01230
uniprot id: A0A8B8UYA8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion

27291:SPAR B00020
gene id: 27291:SPAR_B00020
uniprot id: A0A8B8UKY7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

27291:SPAR D03540
gene id: 27291:SPAR_D03540
uniprot id: A0A8B8UNP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

27291:SPAR J01490
gene id: 27291:SPAR_J01490
uniprot id: A0A8B8UTZ8
names: Similarity
messages: Belongs to the VPS26 family.

27291:SPAR E00230
gene id: 27291:SPAR_E00230
uniprot id: A0A8B8UQ23
names: Similarity
messages: Belongs to the AFG1 ATPase family.

27291:SPAR I01550
gene id: 27291:SPAR_I01550
uniprot id: A0A8B8UTD2
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

27291:SPAR B01040
gene id: 27291:SPAR_B01040
uniprot id: A0A8B8ULF3
names: Similarity
messages: Belongs to the UPF0045 family.

27291:SPAR N02690
gene id: 27291:SPAR_N02690
uniprot id: A0A8B8UYQ1
names: Similarity
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Octamer of two non-identical subunits IDH1 and IDH2.

27291:SPAR G03010
gene id: 27291:SPAR_G03010
uniprot id: A0A8B8URQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

27291:SPAR J02130
gene id: 27291:SPAR_J02130
uniprot id: A0A8B8UU89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 3-HAO family.
messages: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
messages: Cytoplasm

27291:SPAR G04080
gene id: 27291:SPAR_G04080
uniprot id: A0A8B8URW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

27291:SPAR M03100
gene id: 27291:SPAR_M03100
uniprot id: A0A8B8UXL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC4 family.
messages: Mitochondrion intermembrane space

27291:SPAR M04410
gene id: 27291:SPAR_M04410
uniprot id: A0A8B8UY29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

27291:SPAR P03600
gene id: 27291:SPAR_P03600
uniprot id: A0A8B8V1H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM MRD1 family.
messages: Nucleus

27291:SPAR P01610
gene id: 27291:SPAR_P01610
uniprot id: A0A8B8V106
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

27291:SPAR E00440
gene id: 27291:SPAR_E00440
uniprot id: A0A8B8UPT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

27291:SPAR A00530
gene id: 27291:SPAR_A00530
uniprot id: A0A8B8ULE7
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

27291:SPAR J01410
gene id: 27291:SPAR_J01410
uniprot id: A0A8B8UU27
names: Subcellular Location Annotation
messages: nuclear pore complex

27291:SPAR O04850
gene id: 27291:SPAR_O04850
uniprot id: A0A8B8V0E7
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 FAD per subunit.

27291:SPAR B01400
gene id: 27291:SPAR_B01400
uniprot id: A0A8B8ULJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCO1/2 family.
messages: Mitochondrion inner membrane

27291:SPAR L04180
gene id: 27291:SPAR_L04180
uniprot id: A0A8B8UWK2
names: Similarity
messages: Belongs to the SRR1 family.

27291:SPAR P02680
gene id: 27291:SPAR_P02680
uniprot id: A0A8B8V172
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
messages: Can also use Mn(2+) ion.

27291:SPAR G01220
gene id: 27291:SPAR_G01220
uniprot id: A0A8B8UR72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIT family. Fungal FIT2B/SCS3 subfamily.
messages: Endoplasmic reticulum membrane
messages: Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.
messages: Membrane

27291:SPAR P03550
gene id: 27291:SPAR_P03550
uniprot id: A0A8B8V1H2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPSF4/YTH1 family.
messages: Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.
messages: Nucleus

27291:SPAR N00850
gene id: 27291:SPAR_N00850
uniprot id: A0A8B8UYC7
names: Similarity
messages: Belongs to the SLA2 family.

27291:SPAR P01230
gene id: 27291:SPAR_P01230
uniprot id: A0A8B8V0S7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: kinetochore
messages: spindle

27291:SPAR H00550
gene id: 27291:SPAR_H00550
uniprot id: A0A8B8USG4
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

27291:SPAR P01770
gene id: 27291:SPAR_P01770
uniprot id: A0A8B8V0Y3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.
messages: Involved in the biogenesis of the 60S ribosomal subunit.
messages: nucleolus

27291:SPAR K01000
gene id: 27291:SPAR_K01000
uniprot id: A0A8B8UUS5
names: Similarity
messages: Belongs to the AP endonuclease 2 family.

27291:SPAR P00220
gene id: 27291:SPAR_P00220
uniprot id: A0A8B8V0H6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BBP1 family.
messages: Component of the spindle pole body (SPB) required for insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication. Connects the central plaque of the SPB with the half-bridge. Required for proper localization of CDC5 at the SPB and for proper M-phase progression.
messages: Homodimer. Interacts with KAR1, MPS2 and SPC29.
messages: spindle pole body

27291:SPAR G03730
gene id: 27291:SPAR_G03730
uniprot id: A0A8B8URT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

27291:SPAR L01170
gene id: 27291:SPAR_L01170
uniprot id: A0A8B8UVU4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

27291:SPAR G04220
gene id: 27291:SPAR_G04220
uniprot id: A0A8B8US27
names: Similarity
messages: Belongs to the thioredoxin family.

27291:SPAR G01780
gene id: 27291:SPAR_G01780
uniprot id: A0A8B8UR88
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

27291:SPAR M01150
gene id: 27291:SPAR_M01150
uniprot id: A0A8B8UX10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

27291:SPAR M00390
gene id: 27291:SPAR_M00390
uniprot id: A0A8B8UWZ1
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

27291:SPAR O00400
gene id: 27291:SPAR_O00400
uniprot id: A0A8B8UZ48
names: Similarity
messages: Belongs to the DNA polymerase type-B-like family.

27291:SPAR L02720
gene id: 27291:SPAR_L02720
uniprot id: A0A8B8UWB4
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

27291:SPAR M03040
gene id: 27291:SPAR_M03040
uniprot id: A0A8B8UXQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvP family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

27291:SPAR F00220
gene id: 27291:SPAR_F00220
uniprot id: A0A8B8UQS6
names: Similarity
messages: Belongs to the multicopper oxidase family.

27291:SPAR E01400
gene id: 27291:SPAR_E01400
uniprot id: A0A8B8UQ49
names: Cofactor
names: Similarity
messages: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
messages: Can also use Mn(2+) ion.

27291:SPAR N01820
gene id: 27291:SPAR_N01820
uniprot id: A0A8B8UYH1
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR B02790
gene id: 27291:SPAR_B02790
uniprot id: A0A8B8ULY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.
messages: Membrane

27291:SPAR O01910
gene id: 27291:SPAR_O01910
uniprot id: A0A8B8UZK6
names: Similarity
messages: Belongs to the lipid-translocating exporter (LTE) (TC 9.A.26.1) family.

27291:SPAR M02820
gene id: 27291:SPAR_M02820
uniprot id: A0A8B8UXH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

27291:SPAR C00840
gene id: 27291:SPAR_C00840
uniprot id: A0A8B8UMU0
names: Subcellular Location Annotation
messages: Mitochondrion

27291:SPAR J00610
gene id: 27291:SPAR_J00610
uniprot id: A0A8B8UTV0
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

27291:SPAR D03880
gene id: 27291:SPAR_D03880
uniprot id: A0A8B8UP42
names: Similarity
messages: Belongs to the cullin family.

27291:SPAR H01130
gene id: 27291:SPAR_H01130
uniprot id: A0A8B8USR2
names: Similarity
messages: Belongs to the terpene cyclase/mutase family.

27291:SPAR G02950
gene id: 27291:SPAR_G02950
uniprot id: A0A8B8URK9
names: Similarity
messages: Belongs to the RENT3 family.

27291:SPAR C01410
gene id: 27291:SPAR_C01410
uniprot id: A0A8B8UMN2
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR E02570
gene id: 27291:SPAR_E02570
uniprot id: A0A8B8UQE3
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

27291:SPAR M02730
gene id: 27291:SPAR_M02730
uniprot id: A0A8B8UXG6
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.

27291:SPAR J01960
gene id: 27291:SPAR_J01960
uniprot id: A0A8B8UU86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Nucleus

27291:SPAR L01200
gene id: 27291:SPAR_L01200
uniprot id: A0A8B8UVV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR M04020
gene id: 27291:SPAR_M04020
uniprot id: A0A8B8UXU2
names: Similarity
messages: Belongs to the RNR ribonuclease family.

27291:SPAR G01640
gene id: 27291:SPAR_G01640
uniprot id: A0A8B8URH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR O01160
gene id: 27291:SPAR_O01160
uniprot id: A0A8B8UZD2
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).

27291:SPAR J00810
gene id: 27291:SPAR_J00810
uniprot id: A0A8B8UTW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrkH potassium transport family.
messages: Membrane

27291:A560 mgp10
gene id: 27291:A560_mgp10
uniprot id: I1Z681
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR P02280
gene id: 27291:SPAR_P02280
uniprot id: A0A8B8V133
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAC-beta family.
messages: Cytoplasm
messages: Nucleus
messages: Part of the nascent polypeptide-associated complex (NAC).

27291:SPAR K00480
gene id: 27291:SPAR_K00480
uniprot id: A0A8B8UUS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP2 family.
messages: nucleolus

27291:SPAR B03410
gene id: 27291:SPAR_B03410
uniprot id: A0A8B8UM37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

27291:SPAR G01430
gene id: 27291:SPAR_G01430
uniprot id: A0A8B8UR50
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

27291:SPAR L00360
gene id: 27291:SPAR_L00360
uniprot id: A0A8B8UVG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

27291:SPAR H00300
gene id: 27291:SPAR_H00300
uniprot id: A0A8B8USD9
names: Function
names: Similarity
messages: Belongs to the UDPGP type 1 family.
messages: Plays a central role as a glucosyl donor in cellular metabolic pathways.

27291:SPAR E00290
gene id: 27291:SPAR_E00290
uniprot id: A0A8B8UPS4
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR D05770
gene id: 27291:SPAR_D05770
uniprot id: A0A8B8UPA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR O00450
gene id: 27291:SPAR_O00450
uniprot id: A0A8B8UZ55
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERF4 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with ERF2.

27291:SPAR M02610
gene id: 27291:SPAR_M02610
uniprot id: A0A8B8UXJ4
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

27291:SPAR E01950
gene id: 27291:SPAR_E01950
uniprot id: A0A8B8UQA3
names: Similarity
messages: Belongs to the universal ribosomal protein uL14 family.

27291:SPAR M02260
gene id: 27291:SPAR_M02260
uniprot id: A0A8B8UXG0
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

27291:SPAR O03030
gene id: 27291:SPAR_O03030
uniprot id: A0A8B8UZW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Mitochondrion inner membrane

27291:SPAR L03810
gene id: 27291:SPAR_L03810
uniprot id: A0A8B8UWF8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC3 family.
messages: Component of the Arp2/3 complex.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton

27291:SPAR M00530
gene id: 27291:SPAR_M00530
uniprot id: A0A8B8UWU4
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

27291:SPAR L03010
gene id: 27291:SPAR_L03010
uniprot id: A0A8B8UW80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Nucleus

27291:SPAR M02220
gene id: 27291:SPAR_M02220
uniprot id: A0A8B8UXB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku80 family.
messages: Nucleus
messages: telomere

27291:SPAR K02900
gene id: 27291:SPAR_K02900
uniprot id: A0A8B8UVB7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

27291:SPAR J00500
gene id: 27291:SPAR_J00500
uniprot id: A0A8B8UTM2
names: Similarity
messages: Belongs to the protein kinase superfamily.

27291:SPAR L03550
gene id: 27291:SPAR_L03550
uniprot id: A0A8B8UWD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 48 family.
messages: Membrane

27291:SPAR N03070
gene id: 27291:SPAR_N03070
uniprot id: A0A8B8UYU2
names: Similarity
messages: Belongs to the SWM2 family.

27291:SPAR F00550
gene id: 27291:SPAR_F00550
uniprot id: A0A8B8UQN5
names: Similarity
messages: Belongs to the BLM10 family.

27291:SPAR G02060
gene id: 27291:SPAR_G02060
uniprot id: A0A8B8URG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CGR1 family.
messages: Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.
messages: nucleolus

27291:SPAR M03360
gene id: 27291:SPAR_M03360
uniprot id: A0A8B8UXS6
names: Similarity
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.

27291:SPAR G03290
gene id: 27291:SPAR_G03290
uniprot id: A0A8B8URZ3
names: Similarity
messages: Belongs to the cyclin family.

27291:SPAR A00330
gene id: 27291:SPAR_A00330
uniprot id: A0A8B8ULC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SNW family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

27291:SPAR N00730
gene id: 27291:SPAR_N00730
uniprot id: A0A8B8UY60
names: Function
names: Similarity
messages: Catalyzes three sequential steps of tetrahydrofolate biosynthesis.
messages: In the C-terminal section; belongs to the DHPS family.
messages: In the N-terminal section; belongs to the DHNA family.
messages: In the central section; belongs to the HPPK family.

27291:SPAR G03360
gene id: 27291:SPAR_G03360
uniprot id: A0A8B8V1I0
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

27291:SPAR O04200
gene id: 27291:SPAR_O04200
uniprot id: A0A8B8V083
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP5/NOP56 family.
messages: nucleolus

27291:SPAR O01980
gene id: 27291:SPAR_O01980
uniprot id: A0A8B8UZL2
names: Similarity
messages: Belongs to the putative lipase ROG1 family.

27291:SPAR F00200
gene id: 27291:SPAR_F00200
uniprot id: A0A8B8UQJ2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.

27291:SPAR K02360
gene id: 27291:SPAR_K02360
uniprot id: A0A8B8UVB1
names: Similarity
messages: Belongs to the SAPS family.

27291:SPAR N01780
gene id: 27291:SPAR_N01780
uniprot id: A0A8B8UYL0
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

27291:SPAR M03870
gene id: 27291:SPAR_M03870
uniprot id: A0A8B8UXS7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family. SCS7 subfamily.
messages: Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.
messages: Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR O03560
gene id: 27291:SPAR_O03560
uniprot id: A0A8B8V016
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OSBP family.
messages: Membrane

27291:SPAR K02660
gene id: 27291:SPAR_K02660
uniprot id: A0A8B8UVE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

27291:SPAR L00560
gene id: 27291:SPAR_L00560
uniprot id: A0A8B8UVI2
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR M01690
gene id: 27291:SPAR_M01690
uniprot id: A0A8B8UXB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin GLFG family.
messages: Nucleus membrane
messages: nuclear pore complex

27291:SPAR B03650
gene id: 27291:SPAR_B03650
uniprot id: A0A8B8UM70
names: Similarity
messages: Belongs to the SDHAF4 family.

27291:SPAR P02640
gene id: 27291:SPAR_P02640
uniprot id: A0A8B8V1B6
names: Similarity
messages: Belongs to the PrpD family.

27291:SPAR P00710
gene id: 27291:SPAR_P00710
uniprot id: A0A8B8V0R9
names: Similarity
messages: Belongs to the protein kinase superfamily.

27291:SPAR G04130
gene id: 27291:SPAR_G04130
uniprot id: A0A8B8URW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ELP2 family.
messages: Cytoplasm
messages: Nucleus

27291:SPAR A00420
gene id: 27291:SPAR_A00420
uniprot id: A0A8B8UKR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

27291:SPAR M03750
gene id: 27291:SPAR_M03750
uniprot id: A0A8B8UXS3
names: Function
names: Similarity
messages: Belongs to the eIF-1A family.
messages: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.

27291:SPAR K00080
gene id: 27291:SPAR_K00080
uniprot id: A0A8B8UUM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.
messages: Cytoplasm
messages: Homodimer.

27291:SPAR G04040
gene id: 27291:SPAR_G04040
uniprot id: A0A8B8US67
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

27291:SPAR B02200
gene id: 27291:SPAR_B02200
uniprot id: A0A8B8ULS4
names: Subcellular Location Annotation
messages: Mitochondrion

27291:SPAR H00730
gene id: 27291:SPAR_H00730
uniprot id: A0A8B8USM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5' to 3' DNA replicative helicase recruited to paused replisomes to promote fork progression throughout nonhistone protein-DNA complexes, naturally occurring impediments that are encountered in each S phase where replication forks pauses. Required for timely replication of the telomere and subtelomeric DNA and for wild-type levels of telomeric silencing. Involved in DNA repair during stalled replication fork, regulation of fragile sites expression and essential for genome stability. Plays also a role in mtDNA replication. Has G-quadruplex (G4) unwinding activity and can suppress G4-induced genome instability when PIF1 levels are low.
messages: Belongs to the helicase family. PIF1 subfamily.
messages: Nucleus
messages: telomere

27291:SPAR E00720
gene id: 27291:SPAR_E00720
uniprot id: A0A8B8UPW1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

27291:SPAR P00960
gene id: 27291:SPAR_P00960
uniprot id: A0A8B8V0U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM NCBP2 family.
messages: Nucleus

27291:SPAR P02430
gene id: 27291:SPAR_P02430
uniprot id: A0A8B8V147
names: Similarity
messages: Belongs to the peptidase C48 family.

27291:SPAR B02800
gene id: 27291:SPAR_B02800
uniprot id: A0A8B8ULY3
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

27291:SPAR B02890
gene id: 27291:SPAR_B02890
uniprot id: A0A8B8ULZ6
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

27291:SPAR G00470
gene id: 27291:SPAR_G00470
uniprot id: A0A8B8UQZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.
messages: Cytoplasm
messages: Interacts with NCS2 and URM1. May act by forming a heterodimer with NCS2. Component of a large molecular weight complex of more than 250 kDa.
messages: Mitochondrion
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.

27291:SPAR H02000
gene id: 27291:SPAR_H02000
uniprot id: A0A8B8UST5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDA11 family.
messages: Cytoplasm

27291:SPAR D04120
gene id: 27291:SPAR_D04120
uniprot id: A0A8B8UNT4
names: Similarity
messages: Belongs to the eIF-2B gamma/epsilon subunits family.

27291:SPAR O01740
gene id: 27291:SPAR_O01740
uniprot id: A0A8B8UZM8
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR E02180
gene id: 27291:SPAR_E02180
uniprot id: A0A8B8UQL1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DDI1 family.
messages: Binds ubiquitin and polyubiquitinated proteins.
messages: Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control.

27291:SPAR O00360
gene id: 27291:SPAR_O00360
uniprot id: A0A8B8UZ52
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

27291:SPAR J02810
gene id: 27291:SPAR_J02810
uniprot id: A0A8B8UUH4
names: Similarity
messages: Belongs to the VPS25 family.

27291:SPAR P03960
gene id: 27291:SPAR_P03960
uniprot id: A0A8B8V1P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

27291:SPAR G03160
gene id: 27291:SPAR_G03160
uniprot id: A0A8B8URR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase PH family.
messages: nucleolus

27291:SPAR D00390
gene id: 27291:SPAR_D00390
uniprot id: A0A8B8UMT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GLE1 family.
messages: nuclear pore complex

27291:SPAR L04610
gene id: 27291:SPAR_L04610
uniprot id: A0A8B8UWP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR O04910
gene id: 27291:SPAR_O04910
uniprot id: A0A8B8V0E9
names: Similarity
messages: Belongs to the enolase family.

27291:SPAR O03860
gene id: 27291:SPAR_O03860
uniprot id: A0A8B8V046
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat WDR12/YTM1 family.
messages: Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.
messages: Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
messages: nucleolus
messages: nucleoplasm

27291:SPAR J00110
gene id: 27291:SPAR_J00110
uniprot id: A0A8B8UTQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oligopeptide OPT transporter family.
messages: Membrane

27291:SPAR H01240
gene id: 27291:SPAR_H01240
uniprot id: A0A8B8USK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the C1D family.
messages: Nucleus
messages: Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.

27291:SPAR E01150
gene id: 27291:SPAR_E01150
uniprot id: A0A8B8UQ26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR P03710
gene id: 27291:SPAR_P03710
uniprot id: A0A8B8V1L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

27291:SPAR O02790
gene id: 27291:SPAR_O02790
uniprot id: A0A8B8UZY0
names: Similarity
messages: Belongs to the universal ribosomal protein uL13 family.

27291:SPAR F00440
gene id: 27291:SPAR_F00440
uniprot id: A0A8B8UQM9
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

27291:SPAR K02260
gene id: 27291:SPAR_K02260
uniprot id: A0A8B8UVA1
names: Similarity
messages: Belongs to the IML2 family.

27291:SPAR J01040
gene id: 27291:SPAR_J01040
uniprot id: A0A8B8UTU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
messages: Mitochondrion

27291:SPAR G04380
gene id: 27291:SPAR_G04380
uniprot id: A0A8B8URZ6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

27291:SPAR G02640
gene id: 27291:SPAR_G02640
uniprot id: A0A8B8URT2
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR J01660
gene id: 27291:SPAR_J01660
uniprot id: A0A8B8UU53
names: Function
names: Similarity
messages: Belongs to the heat shock protein 70 family.
messages: Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.

27291:SPAR E01300
gene id: 27291:SPAR_E01300
uniprot id: A0A8B8UQ39
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

27291:SPAR M00780
gene id: 27291:SPAR_M00780
uniprot id: A0A8B8UWW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS2 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR P03480
gene id: 27291:SPAR_P03480
uniprot id: A0A8B8V1F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL43 family.
messages: Mitochondrion

27291:SPAR G03610
gene id: 27291:SPAR_G03610
uniprot id: A0A8B8URW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat NOL10/ENP2 family.
messages: nucleolus

27291:SPAR K00250
gene id: 27291:SPAR_K00250
uniprot id: A0A8B8UUK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Cell membrane
messages: Membrane

27291:SPAR O01830
gene id: 27291:SPAR_O01830
uniprot id: A0A8B8UZJ7
names: Function
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

27291:SPAR N01790
gene id: 27291:SPAR_N01790
uniprot id: A0A8B8UYG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EAF7 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.
messages: Nucleus

27291:SPAR G00270
gene id: 27291:SPAR_G00270
uniprot id: A0A8B8UQX6
names: Function
names: Similarity
messages: Belongs to the SEC15 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

27291:SPAR N01910
gene id: 27291:SPAR_N01910
uniprot id: A0A8B8UYN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAF1 family.
messages: Nucleus

27291:SPAR N03390
gene id: 27291:SPAR_N03390
uniprot id: A0A8B8UYX3
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

27291:SPAR H02545
gene id: 27291:SPAR_H02545
uniprot id: A0A8B8USY6
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

27291:SPAR M01470
gene id: 27291:SPAR_M01470
uniprot id: A0A8B8UX37
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.

27291:SPAR P03770
gene id: 27291:SPAR_P03770
uniprot id: A0A8B8V1I0
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

27291:SPAR D00720
gene id: 27291:SPAR_D00720
uniprot id: A0A8B8UMU4
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR B00680
gene id: 27291:SPAR_B00680
uniprot id: A0A8B8ULP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
messages: Belongs to the adaptor complexes large subunit family.
messages: coated pit

27291:SPAR E00310
gene id: 27291:SPAR_E00310
uniprot id: A0A8B8UPT0
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

27291:SPAR I00420
gene id: 27291:SPAR_I00420
uniprot id: A0A8B8UT30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MET18/MMS19 family.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.
messages: Nucleus

27291:SPAR L00540
gene id: 27291:SPAR_L00540
uniprot id: A0A8B8UVI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC3 family.
messages: Nucleus

27291:SPAR D01310
gene id: 27291:SPAR_D01310
uniprot id: A0A8B8UN24
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR B03450
gene id: 27291:SPAR_B03450
uniprot id: A0A8B8UM53
names: Similarity
messages: Belongs to the class-I DAHP synthase family.

27291:SPAR G03960
gene id: 27291:SPAR_G03960
uniprot id: A0A8B8US01
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR P02660
gene id: 27291:SPAR_P02660
uniprot id: A0A8B8V1A8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.
messages: Heterodimer of an alpha and a beta subunit.
messages: Mitochondrion matrix
messages: The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

27291:SPAR N02100
gene id: 27291:SPAR_N02100
uniprot id: A0A8B8UYK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid/polyamine transporter 2 family.
messages: Vacuole membrane

27291:SPAR G01690
gene id: 27291:SPAR_G01690
uniprot id: A0A8B8URI0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MPS2 family.
messages: Component of the spindle pole body (SPB) required for insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication.
messages: Interacts with BBP1, MPS3, and SPC24.
messages: Membrane
messages: Nucleus membrane
messages: spindle pole body

27291:SPAR D06050
gene id: 27291:SPAR_D06050
uniprot id: A0A8B8UPF5
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR L04310
gene id: 27291:SPAR_L04310
uniprot id: A0A8B8UWL2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

27291:SPAR M04390
gene id: 27291:SPAR_M04390
uniprot id: A0A8B8UY35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR O01030
gene id: 27291:SPAR_O01030
uniprot id: A0A8B8UZB5
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

27291:SPAR N02760
gene id: 27291:SPAR_N02760
uniprot id: A0A8B8ULT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

27291:SPAR B01050
gene id: 27291:SPAR_B01050
uniprot id: A0A8B8ULG3
names: Similarity
messages: Belongs to the glycosyl hydrolase 37 family.

27291:SPAR P02810
gene id: 27291:SPAR_P02810
uniprot id: A0A8B8V1C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane

27291:SPAR H01650
gene id: 27291:SPAR_H01650
uniprot id: A0A8B8UST3
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

27291:SPAR J02260
gene id: 27291:SPAR_J02260
uniprot id: A0A8B8UUB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

27291:SPAR J02760
gene id: 27291:SPAR_J02760
uniprot id: A0A8B8UUG9
names: Function
names: Similarity
messages: Belongs to the DPH4 family.
messages: Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.

27291:SPAR G01190
gene id: 27291:SPAR_G01190
uniprot id: A0A8B8URD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS29 family.
messages: Mitochondrion

27291:SPAR G03230
gene id: 27291:SPAR_G03230
uniprot id: A0A8B8URN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Required for proper protein synthesis within the mitochondrion.
messages: Belongs to the GatF family.
messages: Mitochondrion inner membrane
messages: Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A, B and F subunits.

27291:SPAR K02000
gene id: 27291:SPAR_K02000
uniprot id: A0A8B8UV29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the pre-60S ribosomal particle.
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
messages: Cytoplasm
messages: nucleolus

27291:SPAR B03880
gene id: 27291:SPAR_B03880
uniprot id: A0A8B8UMK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane

27291:SPAR K00950
gene id: 27291:SPAR_K00950
uniprot id: A0A8B8UUS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR F00230
gene id: 27291:SPAR_F00230
uniprot id: A0A8B8UQH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR K02390
gene id: 27291:SPAR_K02390
uniprot id: A0A8B8UV56
names: Similarity
messages: Belongs to the phospholipase D family.

27291:SPAR O02570
gene id: 27291:SPAR_O02570
uniprot id: A0A8B8UZW7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing COQ3 and COQ4 polypeptides.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Mitochondrion inner membrane

27291:SPAR L00270
gene id: 27291:SPAR_L00270
uniprot id: A0A8B8UVK1
names: Function
names: Similarity
messages: Belongs to the IRC19 family.
messages: Involved in sporulation and maintenance of the mitochondrial DNA. Is probably involved in a pathway contributing to genomic integrity.

27291:SPAR L00470
gene id: 27291:SPAR_L00470
uniprot id: A0A8B8UVM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DCAF13/WDSOF1 family.
messages: nucleolus

27291:SPAR B01120
gene id: 27291:SPAR_B01120
uniprot id: A0A8B8ULC5
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR H01330
gene id: 27291:SPAR_H01330
uniprot id: A0A8B8UST2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

27291:SPAR D06040
gene id: 27291:SPAR_D06040
uniprot id: A0A8B8UPS3
names: Similarity
messages: Belongs to the universal ribosomal protein uL11 family.

27291:SPAR L01860
gene id: 27291:SPAR_L01860
uniprot id: A0A8B8UVW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fungal Na(+)/H(+) exchanger family.
messages: Membrane

27291:SPAR M02640
gene id: 27291:SPAR_M02640
uniprot id: A0A8B8UXL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OSW5 family.
messages: Involved in spore wall assembly.
messages: Membrane

27291:SPAR D04290
gene id: 27291:SPAR_D04290
uniprot id: A0A8B8UNW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX20 family.
messages: Involved in the assembly of the cytochrome c oxidase complex.
messages: Mitochondrion inner membrane

27291:SPAR G00250
gene id: 27291:SPAR_G00250
uniprot id: A0A8B8UQU4
names: Function
names: Similarity
messages: Belongs to the MnmG family.
messages: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.

27291:SPAR G01960
gene id: 27291:SPAR_G01960
uniprot id: A0A8B8URF2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
messages: Homooctamer.

27291:SPAR B03330
gene id: 27291:SPAR_B03330
uniprot id: A0A8B8UMF4
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

27291:SPAR L01640
gene id: 27291:SPAR_L01640
uniprot id: A0A8B8UVU1
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Nucleus

27291:SPAR M02240
gene id: 27291:SPAR_M02240
uniprot id: A0A8B8UXH6
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

27291:SPAR D06010
gene id: 27291:SPAR_D06010
uniprot id: A0A8B8UPE1
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR B00190
gene id: 27291:SPAR_B00190
uniprot id: A0A8B8UL58
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

27291:SPAR E00380
gene id: 27291:SPAR_E00380
uniprot id: A0A8B8UQ37
names: Function
names: PTM
names: Similarity
messages: Belongs to the eIF-5A family.
messages: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.

27291:SPAR B03860
gene id: 27291:SPAR_B03860
uniprot id: A0A8B8UM85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR N00930
gene id: 27291:SPAR_N00930
uniprot id: A0A8B8UY79
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

27291:SPAR G02160
gene id: 27291:SPAR_G02160
uniprot id: A0A8B8URH4
names: Similarity
messages: Belongs to the HscB family.

27291:SPAR O03200
gene id: 27291:SPAR_O03200
uniprot id: A0A8B8UZY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 1 family.
messages: Nucleus

27291:SPAR G04270
gene id: 27291:SPAR_G04270
uniprot id: A0A8B8US30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS2 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.
messages: Cytoplasm
messages: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.

27291:SPAR K01890
gene id: 27291:SPAR_K01890
uniprot id: A0A8B8UV08
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

27291:SPAR B03590
gene id: 27291:SPAR_B03590
uniprot id: A0A8B8UM69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic12 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

27291:SPAR G04120
gene id: 27291:SPAR_G04120
uniprot id: A0A8B8US15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

27291:SPAR B03820
gene id: 27291:SPAR_B03820
uniprot id: A0A8B8UM52
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR D01530
gene id: 27291:SPAR_D01530
uniprot id: A0A8B8UNF4
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

27291:SPAR O04670
gene id: 27291:SPAR_O04670
uniprot id: A0A8B8V0H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transient receptor potential (TRP) ion channel family.
messages: Membrane

27291:SPAR L00440
gene id: 27291:SPAR_L00440
uniprot id: A0A8B8UVH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC6 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR P02840
gene id: 27291:SPAR_P02840
uniprot id: A0A8B8V1D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRG family.
messages: Nucleus

27291:SPAR G02440
gene id: 27291:SPAR_G02440
uniprot id: A0A8B8URR3
names: Function
names: Similarity
messages: Belongs to the SNU71 family.
messages: Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway.

27291:SPAR O01880
gene id: 27291:SPAR_O01880
uniprot id: A0A8B8UZK2
names: Similarity
messages: Belongs to the DEAD box helicase family.

27291:SPAR D01510
gene id: 27291:SPAR_D01510
uniprot id: A0A8B8UN42
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

27291:SPAR J02490
gene id: 27291:SPAR_J02490
uniprot id: A0A8B8UU87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YAE1 family.
messages: Cytoplasm
messages: Nucleus

27291:SPAR E01780
gene id: 27291:SPAR_E01780
uniprot id: A0A8B8UQG5
names: Function
names: Similarity
messages: 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

27291:SPAR J00790
gene id: 27291:SPAR_J00790
uniprot id: A0A8B8UTS8
names: Similarity
messages: Belongs to the AIM23 family.

27291:SPAR M01800
gene id: 27291:SPAR_M01800
uniprot id: A0A8B8UX75
names: Function
names: Subcellular Location Annotation
messages: Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
messages: Cytoplasm
messages: Nucleus

27291:SPAR F00120
gene id: 27291:SPAR_F00120
uniprot id: A0A8B8UQR5
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR E01750
gene id: 27291:SPAR_E01750
uniprot id: A0A8B8UQ83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Nucleus
messages: Required both for recombination and for the repair of DNA damage caused by X-rays.

27291:SPAR N00570
gene id: 27291:SPAR_N00570
uniprot id: A0A8B8UY92
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

27291:SPAR L02600
gene id: 27291:SPAR_L02600
uniprot id: A0A8B8UW40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
messages: Cell membrane
messages: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state.

27291:SPAR A00050
gene id: 27291:SPAR_A00050
uniprot id: A0A8B8UKV2
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

27291:SPAR N02820
gene id: 27291:SPAR_N02820
uniprot id: A0A8B8UYR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.

27291:SPAR G01010
gene id: 27291:SPAR_G01010
uniprot id: A0A8B8UR53
names: Cofactor
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Reduced FMN (FMNH(2)).

27291:SPAR J02520
gene id: 27291:SPAR_J02520
uniprot id: A0A8B8UU90
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the deoxyhypusine hydroxylase family.
messages: Binds 2 Fe(2+) ions per subunit.
messages: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.
messages: Cytoplasm
messages: Nucleus

27291:SPAR C01400
gene id: 27291:SPAR_C01400
uniprot id: A0A8B8UMP2
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR D00910
gene id: 27291:SPAR_D00910
uniprot id: A0A8B8UMY3
names: Similarity
messages: Belongs to the proteasome subunit p55 family.

27291:SPAR D01070
gene id: 27291:SPAR_D01070
uniprot id: A0A8B8UMX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase inhibitor family.
messages: Inhibits the enzyme activity of ATPase.
messages: Mitochondrion

27291:SPAR H00580
gene id: 27291:SPAR_H00580
uniprot id: A0A8B8USL5
names: Similarity
messages: Belongs to the SH3YL1 family.

27291:SPAR E02290
gene id: 27291:SPAR_E02290
uniprot id: A0A8B8UQC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

27291:SPAR J00800
gene id: 27291:SPAR_J00800
uniprot id: A0A8B8UTQ7
names: Similarity
messages: In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.

27291:SPAR L00300
gene id: 27291:SPAR_L00300
uniprot id: A0A8B8UVL2
names: Similarity
messages: Belongs to the peptidase M24B family.

27291:SPAR G01350
gene id: 27291:SPAR_G01350
uniprot id: A0A8B8UR54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

27291:SPAR G03490
gene id: 27291:SPAR_G03490
uniprot id: A0A8B8US12
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR H00380
gene id: 27291:SPAR_H00380
uniprot id: A0A8B8USJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingosine N-acyltransferase family.
messages: Membrane

27291:SPAR D03820
gene id: 27291:SPAR_D03820
uniprot id: A0A8B8UNQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NGG1 family.
messages: Nucleus

27291:SPAR O01150
gene id: 27291:SPAR_O01150
uniprot id: A0A8B8UZC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC5 subfamily.
messages: Nucleus

27291:SPAR O04270
gene id: 27291:SPAR_O04270
uniprot id: A0A8B8V0E0
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR M01000
gene id: 27291:SPAR_M01000
uniprot id: A0A8B8UWZ6
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

27291:SPAR M02050
gene id: 27291:SPAR_M02050
uniprot id: A0A8B8UXA8
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR K02030
gene id: 27291:SPAR_K02030
uniprot id: A0A8B8UV76
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR P03010
gene id: 27291:SPAR_P03010
uniprot id: A0A8B8V1E4
names: Similarity
messages: Belongs to the TIP41 family.

27291:SPAR M03420
gene id: 27291:SPAR_M03420
uniprot id: A0A8B8UXN3
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

27291:SPAR P01260
gene id: 27291:SPAR_P01260
uniprot id: A0A8B8V0X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.
messages: Membrane
messages: Peroxisome membrane

27291:SPAR G02020
gene id: 27291:SPAR_G02020
uniprot id: A0A8B8URF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HOP2 family.
messages: Nucleus

27291:SPAR N02000
gene id: 27291:SPAR_N02000
uniprot id: A0A8B8UYJ1
names: Similarity
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.

27291:SPAR E01490
gene id: 27291:SPAR_E01490
uniprot id: A0A8B8UT72
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

27291:SPAR M01340
gene id: 27291:SPAR_M01340
uniprot id: A0A8B8UX86
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR L03530
gene id: 27291:SPAR_L03530
uniprot id: A0A8B8UWD7
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.

27291:SPAR F00520
gene id: 27291:SPAR_F00520
uniprot id: A0A8B8UQV2
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR K01320
gene id: 27291:SPAR_K01320
uniprot id: A0A8B8UUU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
messages: cytoskeleton

27291:SPAR M02550
gene id: 27291:SPAR_M02550
uniprot id: A0A8B8UXF8
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

27291:SPAR K02170
gene id: 27291:SPAR_K02170
uniprot id: A0A8B8UV33
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR H01230
gene id: 27291:SPAR_H01230
uniprot id: A0A8B8USS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YSP2 family.
messages: Membrane

27291:SPAR I00780
gene id: 27291:SPAR_I00780
uniprot id: A0A8B8UTA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UTP25 family.
messages: Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.
messages: DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.
messages: nucleolus

27291:SPAR D01430
gene id: 27291:SPAR_D01430
uniprot id: A0A8B8UNE4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP14 family.
messages: Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).
messages: Cytoplasm

27291:SPAR D06280
gene id: 27291:SPAR_D06280
uniprot id: A0A8B8UPF2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

27291:SPAR B03230
gene id: 27291:SPAR_B03230
uniprot id: A0A8B8UME4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SLX1 family.
messages: Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for simple Y, 5'-flap and replication fork-like structures. It cleaves the strand bearing the 5'-non-homologous arm at the branch site junction and generates ligatable, nicked products from the 5'-flap or replication fork substrates. Plays a critical role in maintaining the integrity of the ribosomal DNA (rDNA) loci, where it has a role in re-starting stalled replication forks. Has Holliday junction resolvase activity in vitro.
messages: Forms a heterodimer with SLX4.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

27291:SPAR B01900
gene id: 27291:SPAR_B01900
uniprot id: A0A8B8ULP4
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR O03110
gene id: 27291:SPAR_O03110
uniprot id: A0A8B8UZX7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ran family.
messages: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.
messages: Nucleus

27291:SPAR M00910
gene id: 27291:SPAR_M00910
uniprot id: A0A8B8UX33
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR B01960
gene id: 27291:SPAR_B01960
uniprot id: A0A8B8ULP0
names: Similarity
messages: Belongs to the histidine acid phosphatase family.

27291:SPAR N02830
gene id: 27291:SPAR_N02830
uniprot id: A0A8B8UYW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NFX1 family.
messages: Nucleus

27291:SPAR D00640
gene id: 27291:SPAR_D00640
uniprot id: A0A8B8UMW1
names: Similarity
messages: Belongs to the cyclin family.

27291:SPAR B02210
gene id: 27291:SPAR_B02210
uniprot id: A0A8B8ULR7
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

27291:SPAR D00220
gene id: 27291:SPAR_D00220
uniprot id: A0A8B8UMP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck

27291:SPAR K02010
gene id: 27291:SPAR_K02010
uniprot id: A0A8B8UV75
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingosine N-acyltransferase family.
messages: Membrane

27291:SPAR H01210
gene id: 27291:SPAR_H01210
uniprot id: A0A8B8USM8
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR D01910
gene id: 27291:SPAR_D01910
uniprot id: A0A8B8UN81
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.

27291:SPAR C01080
gene id: 27291:SPAR_C01080
uniprot id: A0A8B8UMH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IMPACT family.
messages: Cytoplasm

27291:SPAR N03620
gene id: 27291:SPAR_N03620
uniprot id: A0A8B8UYZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferric reductase (FRE) family.
messages: Cell membrane
messages: Membrane

27291:SPAR L02560
gene id: 27291:SPAR_L02560
uniprot id: A0A8B8UW33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SVF1 family.
messages: Cytoplasm

27291:SPAR P02190
gene id: 27291:SPAR_P02190
uniprot id: A0A8B8V169
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SGF11 family.
messages: Component of the 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5 distinct domains with specialized functions. Within the SAGA complex, SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with SGF73, SUS1 and UBP8.
messages: Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). Involved in transcriptional regulation of a subset of SAGA-regulated genes. Within the SAGA complex, participates in a subcomplex, that specifically deubiquitinates histones H2B.
messages: Nucleus
messages: The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of UBP8 forms the 'catalytic lobe' of the SAGA deubiquitination module.
messages: The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module.

27291:SPAR O04390
gene id: 27291:SPAR_O04390
uniprot id: A0A8B8V0E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mitochondrion inner membrane

27291:SPAR O01210
gene id: 27291:SPAR_O01210
uniprot id: A0A8B8UZD7
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR F01150
gene id: 27291:SPAR_F01150
uniprot id: A0A8B8UQU5
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR O00900
gene id: 27291:SPAR_O00900
uniprot id: A0A8B8UZ99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Membrane

27291:SPAR J02840
gene id: 27291:SPAR_J02840
uniprot id: A0A8B8UUB9
names: Function
names: Similarity
messages: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
messages: Belongs to the carbohydrate kinase PfkB family.

27291:SPAR K02520
gene id: 27291:SPAR_K02520
uniprot id: A0A8B8UV67
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

27291:SPAR M00140
gene id: 27291:SPAR_M00140
uniprot id: A0A8B8UWX1
names: Similarity
messages: Belongs to the NADH dehydrogenase family.

27291:SPAR D05590
gene id: 27291:SPAR_D05590
uniprot id: A0A8B8UP92
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family.

27291:SPAR C00010
gene id: 27291:SPAR_C00010
uniprot id: A0A8B8UM95
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR P02550
gene id: 27291:SPAR_P02550
uniprot id: A0A8B8V171
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR B02320
gene id: 27291:SPAR_B02320
uniprot id: A0A8B8ULQ3
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR B01860
gene id: 27291:SPAR_B01860
uniprot id: A0A8B8ULN3
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

27291:SPAR J00770
gene id: 27291:SPAR_J00770
uniprot id: A0A8B8UTQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

27291:SPAR N02260
gene id: 27291:SPAR_N02260
uniprot id: A0A8B8UYR8
names: Similarity
messages: Belongs to the END3 family.

27291:SPAR P02020
gene id: 27291:SPAR_P02020
uniprot id: A0A8B8V107
names: Function
names: Similarity
messages: Belongs to the VPS28 family.
messages: Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.

27291:SPAR G03500
gene id: 27291:SPAR_G03500
uniprot id: A0A8B8URR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prohibitin family.
messages: Mitochondrion inner membrane

27291:SPAR O00950
gene id: 27291:SPAR_O00950
uniprot id: A0A8B8UZA3
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M49 family.
messages: Binds 1 zinc ion per subunit.

27291:SPAR D06830
gene id: 27291:SPAR_D06830
uniprot id: A0A8B8UPL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

27291:SPAR M03210
gene id: 27291:SPAR_M03210
uniprot id: A0A8B8UXR1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Heterooctamer of 4 alpha and 4 beta chains.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

27291:SPAR M02410
gene id: 27291:SPAR_M02410
uniprot id: A0A8B8UXH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NCBP1 family.
messages: Nucleus

27291:SPAR O04190
gene id: 27291:SPAR_O04190
uniprot id: A0A8B8V0C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNU66/SART1 family.
messages: Nucleus

27291:SPAR L04520
gene id: 27291:SPAR_L04520
uniprot id: A0A8B8UWU6
names: Similarity
messages: Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.

27291:SPAR L00250
gene id: 27291:SPAR_L00250
uniprot id: A0A8B8UVK9
names: Similarity
messages: Belongs to the Clp1 family. NOL9/GRC3 subfamily.

27291:SPAR D06020
gene id: 27291:SPAR_D06020
uniprot id: A0A8B8UPC7
names: Similarity
messages: Belongs to the peptidase M28 family.

27291:SPAR J01670
gene id: 27291:SPAR_J01670
uniprot id: A0A8B8UU08
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
messages: nucleolus

27291:SPAR M04240
gene id: 27291:SPAR_M04240
uniprot id: A0A8B8UY21
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

27291:SPAR A00120
gene id: 27291:SPAR_A00120
uniprot id: A0A8B8UKK9
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

27291:SPAR K00660
gene id: 27291:SPAR_K00660
uniprot id: A0A8B8UUU1
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

27291:SPAR H00040
gene id: 27291:SPAR_H00040
uniprot id: A0A8B8US89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. RKM1 family.
messages: Cytoplasm
messages: S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase.

27291:SPAR D03070
gene id: 27291:SPAR_D03070
uniprot id: A0A8B8UNI4
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR L04490
gene id: 27291:SPAR_L04490
uniprot id: A0A8B8UWR8
names: Similarity
messages: Belongs to the hexokinase family.

27291:SPAR L01270
gene id: 27291:SPAR_L01270
uniprot id: A0A8B8UVV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YSP2 family.
messages: Membrane

27291:SPAR G04920
gene id: 27291:SPAR_G04920
uniprot id: A0A8B8US93
names: Cofactor
names: Similarity
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

27291:SPAR B00510
gene id: 27291:SPAR_B00510
uniprot id: A0A8B8ULA1
names: Similarity
messages: Belongs to the PP2C family.

27291:SPAR B00240
gene id: 27291:SPAR_B00240
uniprot id: A0A8B8UL64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. ATM subfamily.
messages: Nucleus
messages: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.
messages: telomere

27291:SPAR J02010
gene id: 27291:SPAR_J02010
uniprot id: A0A8B8UU91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPCS1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR D05480
gene id: 27291:SPAR_D05480
uniprot id: A0A8B8UPJ7
names: Function
names: Similarity
messages: Belongs to the EAF1 family.
messages: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.

27291:SPAR G04150
gene id: 27291:SPAR_G04150
uniprot id: A0A8B8URX8
names: Similarity
messages: Belongs to the cytidylyltransferase family.

27291:SPAR P02620
gene id: 27291:SPAR_P02620
uniprot id: A0A8B8V170
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAT1 family.
messages: Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.
messages: Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.
messages: Cytoplasm
messages: Nucleus

27291:SPAR N00210
gene id: 27291:SPAR_N00210
uniprot id: A0A8B8UY13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP11 family.
messages: Mitochondrion

27291:SPAR A00040
gene id: 27291:SPAR_A00040
uniprot id: A0A8B8UKS5
names: Similarity
messages: Belongs to the flocculin family.

27291:SPAR L01160
gene id: 27291:SPAR_L01160
uniprot id: A0A8B8UVP5
names: Similarity
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Tetramer of two alpha and two beta subunits.

27291:SPAR F00940
gene id: 27291:SPAR_F00940
uniprot id: A0A8B8UQS8
names: Similarity
messages: Belongs to the UQCRH/QCR6 family.

27291:SPAR I01590
gene id: 27291:SPAR_I01590
uniprot id: A0A8B8UTG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AIM21 family.
messages: Interacts with ribosomes. Interacts with ABP1.
messages: Involved in mitochondrial migration along actin filaments.
messages: actin patch

27291:SPAR J00900
gene id: 27291:SPAR_J00900
uniprot id: A0A8B8UTR9
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

27291:SPAR E01550
gene id: 27291:SPAR_E01550
uniprot id: A0A8B8UQ65
names: Similarity
messages: Belongs to the peptidase M24B family.

27291:SPAR K02180
gene id: 27291:SPAR_K02180
uniprot id: A0A8B8UV90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Peroxisome

27291:SPAR O02160
gene id: 27291:SPAR_O02160
uniprot id: A0A8B8UZN5
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR B02630
gene id: 27291:SPAR_B02630
uniprot id: A0A8B8UM81
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EXO5 family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Mitochondrion
messages: Monomer.
messages: Single strand DNA specific 5' exonuclease involved in mitochondrial DNA replication and recombination. Releases dinucleotides as main products of catalysis. Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively.

27291:SPAR N01420
gene id: 27291:SPAR_N01420
uniprot id: A0A8B8UYH4
names: Similarity
messages: Belongs to the universal ribosomal protein uS3 family.

27291:SPAR G01290
gene id: 27291:SPAR_G01290
uniprot id: A0A8B8URE2
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

27291:SPAR K02380
gene id: 27291:SPAR_K02380
uniprot id: A0A8B8UVB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-50 family.
messages: Membrane

27291:SPAR D02730
gene id: 27291:SPAR_D02730
uniprot id: A0A8B8UNS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OS-9 family.
messages: Endoplasmic reticulum membrane
messages: Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.

27291:SPAR O03130
gene id: 27291:SPAR_O03130
uniprot id: A0A8B8UZX8
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

27291:SPAR N02800
gene id: 27291:SPAR_N02800
uniprot id: A0A8B8UYR6
names: Similarity
messages: Belongs to the cyclin family.

27291:SPAR N02020
gene id: 27291:SPAR_N02020
uniprot id: A0A8B8UYJ2
names: Similarity
messages: Belongs to the cytochrome b5 family.

27291:SPAR F00050
gene id: 27291:SPAR_F00050
uniprot id: A0A8B8UQH2
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR H00760
gene id: 27291:SPAR_H00760
uniprot id: A0A8B8USH9
names: Similarity
messages: Belongs to the PIH1 family.

27291:SPAR B01210
gene id: 27291:SPAR_B01210
uniprot id: A0A8B8ULH1
names: Subcellular Location Annotation
messages: Cytoplasm

27291:SPAR K00680
gene id: 27291:SPAR_K00680
uniprot id: A0A8B8UUU2
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

27291:SPAR I00020
gene id: 27291:SPAR_I00020
uniprot id: A0A8B8UTH9
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR E00010
gene id: 27291:SPAR_E00010
uniprot id: A0A8B8UPQ2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

27291:SPAR I01300
gene id: 27291:SPAR_I01300
uniprot id: A0A8B8UTA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane magnesium transporter (TC 1.A.67) family.
messages: Membrane

27291:SPAR G01930
gene id: 27291:SPAR_G01930
uniprot id: A0A8B8URA3
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR O00760
gene id: 27291:SPAR_O00760
uniprot id: A0A8B8UZ92
names: Similarity
messages: Belongs to the BRX1 family.

27291:SPAR N00090
gene id: 27291:SPAR_N00090
uniprot id: A0A8B8UXZ8
names: Subcellular Location Annotation
messages: Peroxisome membrane
messages: cytosol

27291:SPAR H00810
gene id: 27291:SPAR_H00810
uniprot id: A0A8B8USI7
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

27291:SPAR G05060
gene id: 27291:SPAR_G05060
uniprot id: A0A8B8USA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Cell membrane
messages: Membrane

27291:SPAR M01920
gene id: 27291:SPAR_M01920
uniprot id: A0A8B8UX81
names: Similarity
messages: Belongs to the cytochrome b5 family.

27291:SPAR O04140
gene id: 27291:SPAR_O04140
uniprot id: A0A8B8V0C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

27291:SPAR D00310
gene id: 27291:SPAR_D00310
uniprot id: A0A8B8UMS3
names: Function
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.

27291:SPAR E00730
gene id: 27291:SPAR_E00730
uniprot id: A0A8B8UQ73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMP52 family.
messages: Membrane
messages: Mitochondrion outer membrane

27291:SPAR P02950
gene id: 27291:SPAR_P02950
uniprot id: A0A8B8V1B1
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

27291:SPAR O03220
gene id: 27291:SPAR_O03220
uniprot id: A0A8B8V031
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Mitochondrion

27291:SPAR J00940
gene id: 27291:SPAR_J00940
uniprot id: A0A8B8UTU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ASF1 family.
messages: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.
messages: Interacts with histone H3.
messages: Nucleus

27291:SPAR O01760
gene id: 27291:SPAR_O01760
uniprot id: A0A8B8UZJ1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
messages: Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Nucleus

27291:SPAR M00410
gene id: 27291:SPAR_M00410
uniprot id: A0A8B8UWX9
names: Function
names: Similarity
messages: Belongs to the peptidase T1A family.
messages: The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.

27291:SPAR P00970
gene id: 27291:SPAR_P00970
uniprot id: A0A8B8V0Q0
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR P01830
gene id: 27291:SPAR_P01830
uniprot id: A0A8B8V0Y6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.

27291:SPAR A00670
gene id: 27291:SPAR_A00670
uniprot id: A0A8B8UKW2
names: Function
names: Similarity
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.

27291:SPAR D00370
gene id: 27291:SPAR_D00370
uniprot id: A0A8B8UMR0
names: Similarity
messages: Belongs to the RRM CWC2 family.

27291:SPAR G00540
gene id: 27291:SPAR_G00540
uniprot id: A0A8B8UR70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Component of the MCM2-7 complex.
messages: Nucleus

27291:SPAR L02780
gene id: 27291:SPAR_L02780
uniprot id: A0A8B8UW60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

27291:SPAR L01890
gene id: 27291:SPAR_L01890
uniprot id: A0A8B8UVW4
names: Function
names: Similarity
messages: Belongs to the proline oxidase family.
messages: Converts proline to delta-1-pyrroline-5-carboxylate.

27291:SPAR M00730
gene id: 27291:SPAR_M00730
uniprot id: A0A8B8UWW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NTE family.
messages: Endoplasmic reticulum membrane
messages: Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis.

27291:SPAR O03330
gene id: 27291:SPAR_O03330
uniprot id: A0A8B8UZZ9
names: Similarity
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.

27291:SPAR M02540
gene id: 27291:SPAR_M02540
uniprot id: A0A8B8UXK6
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR N00460
gene id: 27291:SPAR_N00460
uniprot id: A0A8B8UY37
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

27291:SPAR D03700
gene id: 27291:SPAR_D03700
uniprot id: A0A8B8UNR0
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

27291:SPAR B00620
gene id: 27291:SPAR_B00620
uniprot id: A0A8B8UL62
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

27291:SPAR N01970
gene id: 27291:SPAR_N01970
uniprot id: A0A8B8UYI5
names: Similarity
messages: Belongs to the malate synthase family.

27291:SPAR E02320
gene id: 27291:SPAR_E02320
uniprot id: A0A8B8UQB9
names: Similarity
messages: Belongs to the COG3 family.

27291:SPAR O04500
gene id: 27291:SPAR_O04500
uniprot id: A0A8B8V0B1
names: Similarity
names: Subunit
messages: Belongs to the pyruvate kinase family.
messages: Homotetramer.

27291:SPAR E01820
gene id: 27291:SPAR_E01820
uniprot id: A0A8B8UQ67
names: Similarity
messages: Belongs to the heat shock protein 70 family.

27291:SPAR L04460
gene id: 27291:SPAR_L04460
uniprot id: A0A8B8UWM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC1 family.
messages: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
messages: Nucleus
messages: ORC is composed of six subunits.

27291:SPAR J01860
gene id: 27291:SPAR_J01860
uniprot id: A0A8B8UU76
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR H00100
gene id: 27291:SPAR_H00100
uniprot id: A0A8B8USB9
names: Similarity
messages: Belongs to the FGGY kinase family.

27291:SPAR B03270
gene id: 27291:SPAR_B03270
uniprot id: A0A8B8ULZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SWC5 family.
messages: Component of the SWR1 chromatin remodeling complex.
messages: Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.
messages: Nucleus

27291:SPAR C00510
gene id: 27291:SPAR_C00510
uniprot id: A0A8B8UME5
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR G01020
gene id: 27291:SPAR_G01020
uniprot id: A0A8B8UR51
names: Similarity
messages: Belongs to the universal ribosomal protein uL6 family.

27291:SPAR O00910
gene id: 27291:SPAR_O00910
uniprot id: A0A8B8UZA7
names: Function
names: Similarity
messages: 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

27291:SPAR G04900
gene id: 27291:SPAR_G04900
uniprot id: A0A8B8US63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SURF4 family.
messages: Membrane

27291:SPAR L01820
gene id: 27291:SPAR_L01820
uniprot id: A0A8B8UW02
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) per subunit.

27291:SPAR E00930
gene id: 27291:SPAR_E00930
uniprot id: A0A8B8UQ95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

27291:SPAR G00080
gene id: 27291:SPAR_G00080
uniprot id: A0A8B8UQR4
names: Similarity
messages: Belongs to the hexokinase family.

27291:SPAR K02730
gene id: 27291:SPAR_K02730
uniprot id: A0A8B8UVE4
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

27291:SPAR H01520
gene id: 27291:SPAR_H01520
uniprot id: A0A8B8USL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Membrane

27291:SPAR I01860
gene id: 27291:SPAR_I01860
uniprot id: A0A8B8UTN7
names: Similarity
messages: Belongs to the malate synthase family.

27291:SPAR M04150
gene id: 27291:SPAR_M04150
uniprot id: A0A8B8UXW3
names: Cofactor
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

27291:SPAR I01250
gene id: 27291:SPAR_I01250
uniprot id: A0A8B8UTA2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the F-actin-capping protein beta subunit family.
messages: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
messages: Heterodimer of an alpha and a beta subunit.
messages: cytoskeleton

27291:SPAR D01580
gene id: 27291:SPAR_D01580
uniprot id: A0A8B8UNF9
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 1 family.
messages: Homodimer.

27291:SPAR E00670
gene id: 27291:SPAR_E00670
uniprot id: A0A8B8UPV7
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

27291:SPAR O02520
gene id: 27291:SPAR_O02520
uniprot id: A0A8B8UZW3
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

27291:SPAR J01990
gene id: 27291:SPAR_J01990
uniprot id: A0A8B8UU37
names: Similarity
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Homotetramer.

27291:SPAR P00420
gene id: 27291:SPAR_P00420
uniprot id: A0A8B8V0J7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.
messages: Vacuole membrane

27291:SPAR L03070
gene id: 27291:SPAR_L03070
uniprot id: A0A8B8UWF2
names: Similarity
messages: Belongs to the glycosyl hydrolase 18 family.

27291:SPAR E00950
gene id: 27291:SPAR_E00950
uniprot id: A0A8B8UQ06
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

27291:SPAR P00140
gene id: 27291:SPAR_P00140
uniprot id: A0A8B8V0L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

27291:SPAR B02910
gene id: 27291:SPAR_B02910
uniprot id: A0A8B8ULY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR J00220
gene id: 27291:SPAR_J00220
uniprot id: A0A8B8UTK4
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR D04440
gene id: 27291:SPAR_D04440
uniprot id: A0A8B8UNY3
names: Similarity
messages: Belongs to the protein kinase superfamily.

27291:SPAR G01760
gene id: 27291:SPAR_G01760
uniprot id: A0A8B8URC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Endoplasmic reticulum membrane
messages: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.

27291:SPAR G00290
gene id: 27291:SPAR_G00290
uniprot id: A0A8B8UR46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMC4 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR J01320
gene id: 27291:SPAR_J01320
uniprot id: A0A8B8UTX4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family.
messages: Mitochondrion
messages: N-acetylglutamate synthase involved in arginine biosynthesis.

27291:SPAR J03280
gene id: 27291:SPAR_J03280
uniprot id: A0A8B8UUL2
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR M03580
gene id: 27291:SPAR_M03580
uniprot id: A0A8B8UXQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

27291:SPAR D00420
gene id: 27291:SPAR_D00420
uniprot id: A0A8B8UMR4
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR J02780
gene id: 27291:SPAR_J02780
uniprot id: A0A8B8UUG0
names: Similarity
messages: Belongs to the peptidase C12 family.

27291:SPAR L04430
gene id: 27291:SPAR_L04430
uniprot id: A0A8B8UWM3
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

27291:SPAR D03890
gene id: 27291:SPAR_D03890
uniprot id: A0A8B8UNT1
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR D06000
gene id: 27291:SPAR_D06000
uniprot id: A0A8B8UPF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP17 family.
messages: nucleolus

27291:SPAR L00660
gene id: 27291:SPAR_L00660
uniprot id: A0A8B8UVJ5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL24 family.

27291:SPAR H01140
gene id: 27291:SPAR_H01140
uniprot id: A0A8B8USJ6
names: Similarity
messages: Belongs to the NOP10 family.

27291:SPAR H01400
gene id: 27291:SPAR_H01400
uniprot id: A0A8B8USQ8
names: Subcellular Location Annotation
messages: Cytoplasm

27291:SPAR H00070
gene id: 27291:SPAR_H00070
uniprot id: A0A8B8US68
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR D00110
gene id: 27291:SPAR_D00110
uniprot id: A0A8B8UMQ0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

27291:SPAR I00100
gene id: 27291:SPAR_I00100
uniprot id: A0A8B8USY0
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

27291:SPAR D04840
gene id: 27291:SPAR_D04840
uniprot id: A0A8B8UP21
names: Similarity
messages: Belongs to the RNR ribonuclease family.

27291:SPAR B01290
gene id: 27291:SPAR_B01290
uniprot id: A0A8B8ULH9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.
messages: Cytoplasm
messages: Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.
messages: Monomer.

27291:SPAR B02050
gene id: 27291:SPAR_B02050
uniprot id: A0A8B8ULQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

27291:SPAR G00060
gene id: 27291:SPAR_G00060
uniprot id: A0A8B8UQW0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

27291:SPAR I00460
gene id: 27291:SPAR_I00460
uniprot id: A0A8B8UTA0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

27291:SPAR K00610
gene id: 27291:SPAR_K00610
uniprot id: A0A8B8UUT6
names: Similarity
messages: Belongs to the RCAN family.

27291:SPAR B03600
gene id: 27291:SPAR_B03600
uniprot id: A0A8B8UM66
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

27291:SPAR D04580
gene id: 27291:SPAR_D04580
uniprot id: A0A8B8UPB0
names: Subcellular Location Annotation
messages: Vacuole

27291:SPAR K02120
gene id: 27291:SPAR_K02120
uniprot id: A0A8B8UV26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OSBP family.
messages: Membrane

27291:SPAR G04890
gene id: 27291:SPAR_G04890
uniprot id: A0A8B8USE7
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily.

27291:SPAR B01220
gene id: 27291:SPAR_B01220
uniprot id: A0A8B8ULD4
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 Fe cation per subunit.
messages: Binds 1 zinc ion per subunit.

27291:SPAR K01580
gene id: 27291:SPAR_K01580
uniprot id: A0A8B8UV32
names: Similarity
messages: Belongs to the TRIAP1/MDM35 family.

27291:SPAR M03820
gene id: 27291:SPAR_M03820
uniprot id: A0A8B8UXS2
names: Similarity
messages: Belongs to the PPase family.

27291:SPAR P02850
gene id: 27291:SPAR_P02850
uniprot id: A0A8B8V1A1
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

27291:SPAR J00090
gene id: 27291:SPAR_J00090
uniprot id: A0A8B8UTL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR N02150
gene id: 27291:SPAR_N02150
uniprot id: A0A8B8UYK6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS7 family.

27291:SPAR K01550
gene id: 27291:SPAR_K01550
uniprot id: A0A8B8UUY0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCTP family.
messages: Involved in protein synthesis. Involved in microtubule stabilization.
messages: cytoskeleton

27291:SPAR M02130
gene id: 27291:SPAR_M02130
uniprot id: A0A8B8UXA1
names: Similarity
messages: Belongs to the PdxS/SNZ family.

27291:SPAR D04570
gene id: 27291:SPAR_D04570
uniprot id: A0A8B8UNX9
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

27291:SPAR M04030
gene id: 27291:SPAR_M04030
uniprot id: A0A8B8UXU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B1 family.
messages: Nucleus

27291:SPAR E01470
gene id: 27291:SPAR_E01470
uniprot id: A0A8B8UQ33
names: Subcellular Location Annotation
messages: Membrane
messages: Vacuole membrane

27291:SPAR N03580
gene id: 27291:SPAR_N03580
uniprot id: A0A8B8UZ42
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR D06370
gene id: 27291:SPAR_D06370
uniprot id: A0A8B8UPH2
names: Similarity
messages: Belongs to the UPL family. TOM1/PTR1 subfamily.

27291:SPAR G01280
gene id: 27291:SPAR_G01280
uniprot id: A0A8B8UR34
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.

27291:SPAR B02420
gene id: 27291:SPAR_B02420
uniprot id: A0A8B8ULR1
names: Similarity
messages: Belongs to the DEAD box helicase family.

27291:SPAR P03910
gene id: 27291:SPAR_P03910
uniprot id: A0A8B8V1N4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. LDAH family.
messages: Lipid droplet

27291:SPAR J02320
gene id: 27291:SPAR_J02320
uniprot id: A0A8B8UU68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ISY1 family.
messages: Nucleus

27291:SPAR H02300
gene id: 27291:SPAR_H02300
uniprot id: A0A8B8USW5
names: Similarity
messages: Belongs to the PTH family.

27291:SPAR P03530
gene id: 27291:SPAR_P03530
uniprot id: A0A8B8V1F8
names: Similarity
messages: Belongs to the COG4 family.

27291:SPAR D02290
gene id: 27291:SPAR_D02290
uniprot id: A0A8B8UNC2
names: Similarity
messages: Belongs to the TCP11 family.

27291:SPAR D01940
gene id: 27291:SPAR_D01940
uniprot id: A0A8B8UN89
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

27291:SPAR K01070
gene id: 27291:SPAR_K01070
uniprot id: A0A8B8UUS4
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

27291:SPAR F01010
gene id: 27291:SPAR_F01010
uniprot id: A0A8B8UQN9
names: Similarity
messages: Belongs to the SAPS family.

27291:SPAR G00420
gene id: 27291:SPAR_G00420
uniprot id: A0A8B8UQZ1
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MDM34 family.
messages: Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.
messages: Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.
messages: Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.
messages: Mitochondrion outer membrane
messages: Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex containing the F-box protein MDM30. Ubiquitination is important for mitochondrial integrity.

27291:SPAR K01830
gene id: 27291:SPAR_K01830
uniprot id: A0A8B8UV57
names: Subcellular Location Annotation
messages: Cytoplasm

27291:SPAR G01980
gene id: 27291:SPAR_G01980
uniprot id: A0A8B8URA8
names: Similarity
messages: Belongs to the glycosyltransferase 32 family.

27291:SPAR C00910
gene id: 27291:SPAR_C00910
uniprot id: A0A8B8UMI6
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

27291:SPAR L02590
gene id: 27291:SPAR_L02590
uniprot id: A0A8B8UW81
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR E01910
gene id: 27291:SPAR_E01910
uniprot id: A0A8B8UQ96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

27291:SPAR L03360
gene id: 27291:SPAR_L03360
uniprot id: Q0P799
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reverse transcriptase family. Telomerase subfamily.
messages: Nucleus
messages: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
messages: telomere

27291:SPAR D04320
gene id: 27291:SPAR_D04320
uniprot id: A0A8B8UNV2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.
messages: Mitochondrion

27291:SPAR L01620
gene id: 27291:SPAR_L01620
uniprot id: A0A8B8UVY6
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

27291:SPAR N02850
gene id: 27291:SPAR_N02850
uniprot id: A0A8B8UYS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD type 2 subfamily.
messages: Nucleus
messages: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

27291:SPAR G04880
gene id: 27291:SPAR_G04880
uniprot id: A0A8B8US44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 17 family.
messages: cell wall

27291:SPAR I01470
gene id: 27291:SPAR_I01470
uniprot id: A0A8B8UTD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EST3 family.
messages: Component of the telomerase complex involved in telomere replication. Stimulates RNA/DNA heteroduplex unwinding which favors the telomere replication by the telomerase.
messages: Nucleus
messages: telomere

27291:SPAR P00690
gene id: 27291:SPAR_P00690
uniprot id: A0A8B8V0S3
names: Similarity
messages: Belongs to the TYW1 family.

27291:SPAR K01560
gene id: 27291:SPAR_K01560
uniprot id: A0A8B8UV30
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

27291:SPAR I01040
gene id: 27291:SPAR_I01040
uniprot id: A0A8B8UTB8
names: Function
names: Similarity
messages: Belongs to the RGI1 family.
messages: Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions.

27291:SPAR B00120
gene id: 27291:SPAR_B00120
uniprot id: A0A8B8UKZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.

27291:SPAR L03240
gene id: 27291:SPAR_L03240
uniprot id: A0A8B8UWE7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

27291:SPAR O00140
gene id: 27291:SPAR_O00140
uniprot id: A0A8B8UZ72
names: Subcellular Location Annotation
messages: nucleolus

27291:SPAR M00050
gene id: 27291:SPAR_M00050
uniprot id: A0A8B8UWQ2
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR P00490
gene id: 27291:SPAR_P00490
uniprot id: A0A8B8V0Q2
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

27291:SPAR D03920
gene id: 27291:SPAR_D03920
uniprot id: A0A8B8UNR6
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

27291:SPAR D06930
gene id: 27291:SPAR_D06930
uniprot id: A0A8B8UPM2
names: Similarity
messages: Belongs to the FKBP-type PPIase family. FKBP2 subfamily.

27291:SPAR J01020
gene id: 27291:SPAR_J01020
uniprot id: A0A8B8UTT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIM16/PAM16 family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation.
messages: Mitochondrion inner membrane

27291:SPAR M02180
gene id: 27291:SPAR_M02180
uniprot id: A0A8B8UXA9
names: Similarity
messages: Belongs to the UPP synthase family.

27291:SPAR D04950
gene id: 27291:SPAR_D04950
uniprot id: A0A8B8UP39
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

27291:SPAR M04230
gene id: 27291:SPAR_M04230
uniprot id: A0A8B8UXW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Membrane
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.

27291:SPAR G02090
gene id: 27291:SPAR_G02090
uniprot id: A0A8B8URM7
names: Similarity
messages: In the C-terminal section; belongs to the TrpB family.
messages: In the N-terminal section; belongs to the TrpA family.

27291:SPAR L04170
gene id: 27291:SPAR_L04170
uniprot id: A0A8B8UWQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
messages: Membrane

27291:SPAR N03310
gene id: 27291:SPAR_N03310
uniprot id: A0A8B8UZ21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR D03110
gene id: 27291:SPAR_D03110
uniprot id: A0A8B8UNJ9
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).

27291:SPAR M03310
gene id: 27291:SPAR_M03310
uniprot id: A0A8B8UXS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Membrane
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.

27291:SPAR N02840
gene id: 27291:SPAR_N02840
uniprot id: A0A8B8UYR7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

27291:SPAR L00330
gene id: 27291:SPAR_L00330
uniprot id: A0A8B8UVF8
names: Similarity
messages: Belongs to the ClpA/ClpB family.

27291:SPAR M03780
gene id: 27291:SPAR_M03780
uniprot id: A0A8B8UXS0
names: Similarity
messages: Belongs to the SAP30 family.

27291:SPAR J01730
gene id: 27291:SPAR_J01730
uniprot id: A0A8B8UU47
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

27291:SPAR J01940
gene id: 27291:SPAR_J01940
uniprot id: A0A8B8UU36
names: Function
names: Similarity
messages: Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.
messages: Belongs to the adaptor complexes large subunit family.

27291:SPAR O02390
gene id: 27291:SPAR_O02390
uniprot id: A0A8B8UZU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

27291:SPAR M03590
gene id: 27291:SPAR_M03590
uniprot id: A0A8B8UXV9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

27291:SPAR D00770
gene id: 27291:SPAR_D00770
uniprot id: A0A8B8UMV0
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

27291:SPAR N03360
gene id: 27291:SPAR_N03360
uniprot id: A0A8B8UZ26
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.

27291:SPAR N01020
gene id: 27291:SPAR_N01020
uniprot id: A0A8B8UYD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cytoplasm
messages: Nucleus
messages: Preautophagosomal structure
messages: Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.

27291:SPAR D02790
gene id: 27291:SPAR_D02790
uniprot id: A0A8B8UNH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.
messages: Cytoplasm
messages: Nucleus

27291:SPAR K02840
gene id: 27291:SPAR_K02840
uniprot id: A0A8B8UVA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPF2 family.
messages: nucleolus

27291:SPAR L02130
gene id: 27291:SPAR_L02130
uniprot id: A0A8B8UVZ4
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

27291:SPAR G03810
gene id: 27291:SPAR_G03810
uniprot id: A0A8B8URY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

27291:SPAR M04290
gene id: 27291:SPAR_M04290
uniprot id: A0A8B8UY26
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

27291:SPAR D01450
gene id: 27291:SPAR_D01450
uniprot id: A0A8B8UN37
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.
messages: Heterodimer of an alpha and a beta subunit.

27291:SPAR P02480
gene id: 27291:SPAR_P02480
uniprot id: A0A8B8V153
names: Cofactor
names: Similarity
messages: Belongs to the sirtuin family. Class I subfamily.
messages: Binds 1 zinc ion per subunit.

27291:SPAR O02940
gene id: 27291:SPAR_O02940
uniprot id: A0A8B8UZZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.
messages: Cooperates with the reticulon proteins RTN1 and RTN2 and the tubule-shaping DP1 family protein YOP1 to generate and maintain the structure of the tubular endoplasmic reticulum network. Has GTPase activity, which is required for its function in ER organization.
messages: Endoplasmic reticulum membrane
messages: Interacts with RTN1 and YOP1; GTP binding is not required for these interactions.

27291:SPAR L03620
gene id: 27291:SPAR_L03620
uniprot id: A0A8B8UWK3
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR L02140
gene id: 27291:SPAR_L02140
uniprot id: A0A8B8UW41
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

27291:SPAR J01580
gene id: 27291:SPAR_J01580
uniprot id: A0A8B8UU33
names: Similarity
messages: Belongs to the nucleoporin NSP1/NUP62 family.

27291:SPAR M00350
gene id: 27291:SPAR_M00350
uniprot id: A0A8B8UWS8
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR O00780
gene id: 27291:SPAR_O00780
uniprot id: A0A8B8UZ90
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR P01680
gene id: 27291:SPAR_P01680
uniprot id: A0A8B8V0X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP4 family.
messages: Cytoplasm
messages: Nucleus

27291:SPAR E00400
gene id: 27291:SPAR_E00400
uniprot id: A0A8B8UPV3
names: Similarity
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.

27291:SPAR I01120
gene id: 27291:SPAR_I01120
uniprot id: A0A8B8UT93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYG1 (TC 2.A.94) family.
messages: Membrane

27291:SPAR C01260
gene id: 27291:SPAR_C01260
uniprot id: A0A8B8UML8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 12 family.
messages: Nucleus

27291:SPAR O00480
gene id: 27291:SPAR_O00480
uniprot id: A0A8B8UZ61
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR C00080
gene id: 27291:SPAR_C00080
uniprot id: A0A8B8UM72
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR N03060
gene id: 27291:SPAR_N03060
uniprot id: A0A8B8UYZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

27291:SPAR L01760
gene id: 27291:SPAR_L01760
uniprot id: A0A8B8UVV5
names: Function
messages: Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.

27291:SPAR P01660
gene id: 27291:SPAR_P01660
uniprot id: A0A8B8V111
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.

27291:SPAR I01630
gene id: 27291:SPAR_I01630
uniprot id: A0A8B8UTJ5
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

27291:SPAR D01160
gene id: 27291:SPAR_D01160
uniprot id: A0A8B8UN08
names: Similarity
messages: Belongs to the peptidase C19 family.

27291:SPAR D04450
gene id: 27291:SPAR_D04450
uniprot id: A0A8B8UNY8
names: Similarity
messages: Belongs to the gluconokinase GntK/GntV family.

27291:SPAR J01610
gene id: 27291:SPAR_J01610
uniprot id: A0A8B8UU48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
messages: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

27291:SPAR I00260
gene id: 27291:SPAR_I00260
uniprot id: A0A8B8UT79
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

27291:SPAR D06760
gene id: 27291:SPAR_D06760
uniprot id: A0A8B8UPM5
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR D03570
gene id: 27291:SPAR_D03570
uniprot id: A0A8B8UNN1
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

27291:SPAR F01140
gene id: 27291:SPAR_F01140
uniprot id: A0A8B8UQV1
names: Similarity
messages: Belongs to the hexokinase family.

27291:SPAR N03240
gene id: 27291:SPAR_N03240
uniprot id: A0A8B8UYV9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.

27291:SPAR D02200
gene id: 27291:SPAR_D02200
uniprot id: A0A8B8UNB2
names: Similarity
messages: Belongs to the ATPase epsilon chain family.

27291:SPAR M01300
gene id: 27291:SPAR_M01300
uniprot id: A0A8B8UX24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF4 family.
messages: Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
messages: Nucleus

27291:SPAR A00110
gene id: 27291:SPAR_A00110
uniprot id: A0A8B8UKU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-22 family.
messages: Involved in peroxisome biogenesis.
messages: Membrane
messages: Peroxisome membrane

27291:SPAR P04020
gene id: 27291:SPAR_P04020
uniprot id: A0A8B8V1K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKN1/KRE6 family.
messages: Membrane

27291:SPAR K00580
gene id: 27291:SPAR_K00580
uniprot id: A0A8B8UUT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
messages: Belongs to the NDUFAF7 family.
messages: Mitochondrion

27291:SPAR D03500
gene id: 27291:SPAR_D03500
uniprot id: A0A8B8UNP1
names: Similarity
messages: Belongs to the dopey family.

27291:SPAR P04110
gene id: 27291:SPAR_P04110
uniprot id: A0A8B8V1R3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 10 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

27291:SPAR G00800
gene id: 27291:SPAR_G00800
uniprot id: A0A8B8UQZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-3' exonuclease family.
messages: Cytoplasm
messages: Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.

27291:SPAR J02830
gene id: 27291:SPAR_J02830
uniprot id: A0A8B8UUG5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

27291:SPAR D01460
gene id: 27291:SPAR_D01460
uniprot id: A0A8B8UN36
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NUR1 family.
messages: Interacts with CSM1.
messages: Member of a perinuclear network that controls recombination at multiple loci to maintain genome stability. Required for rDNA repeat stability.
messages: Membrane
messages: Nucleus membrane

27291:SPAR O02350
gene id: 27291:SPAR_O02350
uniprot id: A0A8B8UZP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

27291:SPAR G02390
gene id: 27291:SPAR_G02390
uniprot id: A0A8B8URQ8
names: Similarity
messages: Belongs to the cytidylyltransferase family.

27291:SPAR M01180
gene id: 27291:SPAR_M01180
uniprot id: A0A8B8UX09
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

27291:SPAR G02740
gene id: 27291:SPAR_G02740
uniprot id: A0A8B8URU1
names: Similarity
messages: Belongs to the UFD1 family.

27291:SPAR N01700
gene id: 27291:SPAR_N01700
uniprot id: A0A8B8UYK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

27291:SPAR C01200
gene id: 27291:SPAR_C01200
uniprot id: A0A8B8UMM1
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.

27291:SPAR C00330
gene id: 27291:SPAR_C00330
uniprot id: A0A8B8UM97
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.

27291:SPAR J00040
gene id: 27291:SPAR_J00040
uniprot id: A0A8B8UTK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR G04630
gene id: 27291:SPAR_G04630
uniprot id: A0A8B8US21
names: Similarity
messages: Belongs to the enolase family.

27291:SPAR P00610
gene id: 27291:SPAR_P00610
uniprot id: A0A8B8V0Q8
names: Similarity
messages: Belongs to the CBP3 family.

27291:SPAR O02180
gene id: 27291:SPAR_O02180
uniprot id: A0A8B8UZN4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PLPL family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lipid hydrolase.
messages: Membrane

27291:SPAR E02450
gene id: 27291:SPAR_E02450
uniprot id: A0A8B8UQH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

27291:SPAR O04410
gene id: 27291:SPAR_O04410
uniprot id: A0A8B8V0A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

27291:SPAR B02820
gene id: 27291:SPAR_B02820
uniprot id: A0A8B8ULV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MEF2 family.
messages: Nucleus

27291:SPAR O00420
gene id: 27291:SPAR_O00420
uniprot id: A0A8B8UZA4
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

27291:SPAR D00760
gene id: 27291:SPAR_D00760
uniprot id: A0A8B8UMW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation.
messages: Cytoplasm
messages: Nucleus

27291:SPAR O03460
gene id: 27291:SPAR_O03460
uniprot id: A0A8B8V007
names: Function
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

27291:SPAR O04860
gene id: 27291:SPAR_O04860
uniprot id: A0A8B8V0E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VEL1 family.
messages: cytosol

27291:SPAR M03620
gene id: 27291:SPAR_M03620
uniprot id: A0A8B8UXQ1
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B family.

27291:SPAR P01440
gene id: 27291:SPAR_P01440
uniprot id: A0A8B8V0Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

27291:SPAR H01890
gene id: 27291:SPAR_H01890
uniprot id: A0A8B8USY7
names: Similarity
messages: Belongs to the universal ribosomal protein uS4 family.

27291:SPAR G02250
gene id: 27291:SPAR_G02250
uniprot id: A0A8B8URD9
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.

27291:SPAR K01790
gene id: 27291:SPAR_K01790
uniprot id: A0A8B8UUZ8
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

27291:SPAR M02620
gene id: 27291:SPAR_M02620
uniprot id: A0A8B8UXF0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit I family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
messages: Cytoplasm

27291:SPAR D04180
gene id: 27291:SPAR_D04180
uniprot id: A0A8B8UP70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Bud neck

27291:SPAR P02820
gene id: 27291:SPAR_P02820
uniprot id: A0A8B8V190
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR D05840
gene id: 27291:SPAR_D05840
uniprot id: A0A8B8UPB9
names: Similarity
messages: Belongs to the AAA ATPase family.

27291:SPAR K02090
gene id: 27291:SPAR_K02090
uniprot id: A0A8B8UV28
names: Function
names: Similarity
messages: Belongs to the APS kinase family.
messages: Catalyzes the synthesis of activated sulfate.

27291:SPAR D06230
gene id: 27291:SPAR_D06230
uniprot id: A0A8B8UPE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
messages: Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
messages: Nucleus

27291:SPAR B01450
gene id: 27291:SPAR_B01450
uniprot id: A0A8B8ULK3
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

27291:SPAR H02460
gene id: 27291:SPAR_H02460
uniprot id: A0A8B8UT15
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

27291:SPAR G00580
gene id: 27291:SPAR_G00580
uniprot id: A0A8B8UQW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

27291:SPAR L01000
gene id: 27291:SPAR_L01000
uniprot id: A0A8B8UVT5
names: Similarity
messages: Belongs to the TOG/XMAP215 family.

27291:SPAR H01280
gene id: 27291:SPAR_H01280
uniprot id: A0A8B8USS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPI1/TEX10 family.
messages: Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.
messages: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.
messages: Nucleus

27291:SPAR A00840
gene id: 27291:SPAR_A00840
uniprot id: A0A8B8UL51
names: Similarity
messages: Belongs to the histidine acid phosphatase family.

27291:SPAR D01960
gene id: 27291:SPAR_D01960
uniprot id: A0A8B8UN86
names: Function
names: Similarity
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.

27291:SPAR J02980
gene id: 27291:SPAR_J02980
uniprot id: A0A8B8UUI1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

27291:SPAR N02290
gene id: 27291:SPAR_N02290
uniprot id: A0A8B8UYL4
names: Similarity
messages: Belongs to the universal ribosomal protein uS13 family.

27291:SPAR E01280
gene id: 27291:SPAR_E01280
uniprot id: A0A8B8UQC4
names: Function
names: Similarity
messages: Belongs to the ATP phosphoribosyltransferase family.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of the enzymatic activity.

27291:SPAR I00750
gene id: 27291:SPAR_I00750
uniprot id: A0A8B8UT52
names: Similarity
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.

27291:SPAR K02600
gene id: 27291:SPAR_K02600
uniprot id: A0A8B8UV89
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

27291:SPAR G04520
gene id: 27291:SPAR_G04520
uniprot id: A0A8B8US53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.
messages: Mediates the uptake of pyruvate into mitochondria.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR J01710
gene id: 27291:SPAR_J01710
uniprot id: A0A8B8UU60
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.

27291:SPAR I01820
gene id: 27291:SPAR_I01820
uniprot id: A0A8B8UTG4
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.
messages: Homotetramer.

27291:SPAR L03780
gene id: 27291:SPAR_L03780
uniprot id: A0A8B8UWG1
names: Similarity
messages: Belongs to the universal ribosomal protein uS8 family.

27291:SPAR I00900
gene id: 27291:SPAR_I00900
uniprot id: A0A8B8UT65
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

27291:SPAR D01240
gene id: 27291:SPAR_D01240
uniprot id: A0A8B8UN18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Endosome membrane
messages: Membrane

27291:SPAR M00650
gene id: 27291:SPAR_M00650
uniprot id: A0A8B8UWV8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

27291:SPAR M00600
gene id: 27291:SPAR_M00600
uniprot id: A0A8B8UWV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG8 family.
messages: Membrane

27291:SPAR P03580
gene id: 27291:SPAR_P03580
uniprot id: A0A8B8V1G3
names: Similarity
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.

27291:SPAR D03180
gene id: 27291:SPAR_D03180
uniprot id: A0A8B8UNX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

27291:SPAR P03340
gene id: 27291:SPAR_P03340
uniprot id: A0A8B8V1I8
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

27291:SPAR P03670
gene id: 27291:SPAR_P03670
uniprot id: A0A8B8V1H0
names: Similarity
messages: Belongs to the cyclin family.

27291:SPAR F00400
gene id: 27291:SPAR_F00400
uniprot id: A0A8B8UQM0
names: Similarity
messages: Belongs to the prefoldin subunit alpha family.

27291:SPAR O01790
gene id: 27291:SPAR_O01790
uniprot id: A0A8B8UZN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntaxin family.
messages: Membrane

27291:SPAR I01200
gene id: 27291:SPAR_I01200
uniprot id: A0A8B8UT97
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR D02550
gene id: 27291:SPAR_D02550
uniprot id: A0A8B8UNE8
names: Similarity
messages: Belongs to the class-I DAHP synthase family.

27291:SPAR A00430
gene id: 27291:SPAR_A00430
uniprot id: A0A8B8ULD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

27291:SPAR M02560
gene id: 27291:SPAR_M02560
uniprot id: A0A8B8UXJ1
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

27291:SPAR N01390
gene id: 27291:SPAR_N01390
uniprot id: A0A8B8UYC8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat IPI3/WDR18 family.
messages: Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.
messages: Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.
messages: Nucleus

27291:SPAR P04090
gene id: 27291:SPAR_P04090
uniprot id: A0A8B8V1T5
names: Similarity
messages: Belongs to the universal ribosomal protein uS14 family.

27291:SPAR N03610
gene id: 27291:SPAR_N03610
uniprot id: A0A8B8UZ49
names: Similarity
messages: Belongs to the MNN1/MNT family.

27291:SPAR O04610
gene id: 27291:SPAR_O04610
uniprot id: A0A8B8V0C3
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR D02420
gene id: 27291:SPAR_D02420
uniprot id: A0A8B8UNB5
names: Similarity
messages: Belongs to the DEAD box helicase family.

27291:SPAR P01520
gene id: 27291:SPAR_P01520
uniprot id: A0A8B8V0V6
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.

27291:SPAR J00460
gene id: 27291:SPAR_J00460
uniprot id: A0A8B8UTU0
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

27291:SPAR O04760
gene id: 27291:SPAR_O04760
uniprot id: A0A8B8V0D7
names: Similarity
names: Subunit
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
messages: Homohexamer.

27291:SPAR P03160
gene id: 27291:SPAR_P03160
uniprot id: A0A8B8V1G0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

27291:SPAR H01000
gene id: 27291:SPAR_H01000
uniprot id: A0A8B8USL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS41 family.
messages: Mitochondrion

27291:SPAR G03720
gene id: 27291:SPAR_G03720
uniprot id: A0A8B8URX5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.
messages: Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

27291:SPAR D01830
gene id: 27291:SPAR_D01830
uniprot id: A0A8B8UNI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KRE9/KNH1 family.
messages: Involved in cell wall beta(1->6) glucan synthesis.
messages: cell wall

27291:SPAR D03260
gene id: 27291:SPAR_D03260
uniprot id: A0A8B8UNL5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

27291:SPAR G03430
gene id: 27291:SPAR_G03430
uniprot id: A0A8B8URQ1
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR K02470
gene id: 27291:SPAR_K02470
uniprot id: A0A8B8UV61
names: Similarity
messages: Belongs to the SUN family.

27291:SPAR L04400
gene id: 27291:SPAR_L04400
uniprot id: A0A8B8UWL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DIF1/spd1 family.
messages: Cytoplasm
messages: Interacts with RNR2 and RNR4.
messages: Mediates the nuclear localization of RNR2 and RNR4, 2 subunits of the ribonucleotide reductase.
messages: Nucleus

27291:SPAR P02740
gene id: 27291:SPAR_P02740
uniprot id: A0A8B8V1C5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR O01190
gene id: 27291:SPAR_O01190
uniprot id: A0A8B8UZH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 72 family.
messages: Cell membrane
messages: Membrane
messages: Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.

27291:SPAR I01810
gene id: 27291:SPAR_I01810
uniprot id: A0A8B8UTN3
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

27291:SPAR M02280
gene id: 27291:SPAR_M02280
uniprot id: A0A8B8UXC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

27291:SPAR E02400
gene id: 27291:SPAR_E02400
uniprot id: A0A8B8UQG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

27291:SPAR O03840
gene id: 27291:SPAR_O03840
uniprot id: A0A8B8V092
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

27291:SPAR M00970
gene id: 27291:SPAR_M00970
uniprot id: A0A8B8UWY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDC1 family.
messages: Membrane
messages: Nucleus membrane
messages: nuclear pore complex

27291:SPAR D00750
gene id: 27291:SPAR_D00750
uniprot id: A0A8B8UMW5
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR K01930
gene id: 27291:SPAR_K01930
uniprot id: A0A8B8UV66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase d subunit family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Mitochondrion inner membrane

27291:SPAR H00630
gene id: 27291:SPAR_H00630
uniprot id: A0A8B8USL8
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

27291:SPAR G02670
gene id: 27291:SPAR_G02670
uniprot id: A0A8B8URM0
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

27291:SPAR P03790
gene id: 27291:SPAR_P03790
uniprot id: A0A8B8V1N7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom5 family.
messages: Membrane
messages: Mitochondrion outer membrane

27291:SPAR A00360
gene id: 27291:SPAR_A00360
uniprot id: A0A8B8UKX8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

27291:SPAR B00820
gene id: 27291:SPAR_B00820
uniprot id: A0A8B8UL92
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

27291:SPAR L00240
gene id: 27291:SPAR_L00240
uniprot id: A0A8B8UVF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat PRP19 family.
messages: Homotetramer.
messages: Nucleus
messages: Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.

27291:SPAR G01660
gene id: 27291:SPAR_G01660
uniprot id: A0A8B8URC0
names: Similarity
messages: Belongs to the DEAD box helicase family.

27291:SPAR D06090
gene id: 27291:SPAR_D06090
uniprot id: A0A8B8UPE3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

27291:SPAR K01440
gene id: 27291:SPAR_K01440
uniprot id: A0A8B8UUW3
names: Similarity
messages: Belongs to the NDK family.

27291:SPAR K01310
gene id: 27291:SPAR_K01310
uniprot id: A0A8B8UV05
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.

27291:SPAR P02440
gene id: 27291:SPAR_P02440
uniprot id: A0A8B8V195
names: Subcellular Location Annotation
messages: Membrane
messages: Vacuole membrane

27291:SPAR N00580
gene id: 27291:SPAR_N00580
uniprot id: A0A8B8UY43
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR P01870
gene id: 27291:SPAR_P01870
uniprot id: A0A8B8V0Z4
names: Subcellular Location Annotation
messages: Nucleus

27291:SPAR B00220
gene id: 27291:SPAR_B00220
uniprot id: A0A8B8UL07
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

27291:SPAR B00840
gene id: 27291:SPAR_B00840
uniprot id: A0A8B8ULD5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: Homoheptamer. Organized in a ring with a central cavity. Oligomerization is independent of its proteolytic activity and the autocatalytic maturation of its subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion matrix

27291:SPAR D06300
gene id: 27291:SPAR_D06300
uniprot id: A0A8B8UPG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP6 family.
messages: nucleolus

27291:SPAR O04170
gene id: 27291:SPAR_O04170
uniprot id: A0A8B8V0C9
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR D05340
gene id: 27291:SPAR_D05340
uniprot id: A0A8B8UP69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR E01440
gene id: 27291:SPAR_E01440
uniprot id: A0A8B8UQ44
names: Similarity
names: Subcellular Location Annotation
messages: In the C-terminal section; belongs to the NAGSA dehydrogenase family.
messages: In the N-terminal section; belongs to the acetylglutamate kinase family.
messages: Mitochondrion

27291:SPAR G00260
gene id: 27291:SPAR_G00260
uniprot id: A0A8B8UQX8
names: Function
names: Similarity
messages: Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.
messages: In the C-terminal section; belongs to the AIR synthase family.
messages: In the N-terminal section; belongs to the GARS family.

27291:SPAR I01640
gene id: 27291:SPAR_I01640
uniprot id: A0A8B8UTH5
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

27291:SPAR O01500
gene id: 27291:SPAR_O01500
uniprot id: A0A8B8UZF9
names: Similarity
messages: Belongs to the peptidase S8 family.

27291:SPAR L03500
gene id: 27291:SPAR_L03500
uniprot id: A0A8B8UWC9
names: Subcellular Location Annotation
messages: nuclear pore complex

27291:SPAR B00350
gene id: 27291:SPAR_B00350
uniprot id: A0A8B8UL93
names: Similarity
messages: Belongs to the AAR2 family.

27291:SPAR P03070
gene id: 27291:SPAR_P03070
uniprot id: A0A8B8V1B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Mitochondrion matrix

27291:SPAR I01770
gene id: 27291:SPAR_I01770
uniprot id: A0A8B8UTF8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR P04320
gene id: 27291:SPAR_P04320
uniprot id: A0A8B8V1N5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

27291:SPAR B00860
gene id: 27291:SPAR_B00860
uniprot id: A0A8B8ULD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFT1 family.
messages: Endoplasmic reticulum membrane
messages: May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane.
messages: Membrane

27291:SPAR L04370
gene id: 27291:SPAR_L04370
uniprot id: A0A8B8UWT1
names: Similarity
names: Subunit
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.
messages: Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

27291:SPAR D02400
gene id: 27291:SPAR_D02400
uniprot id: A0A8B8UND3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvT family.
messages: Mitochondrion
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

27291:SPAR E02140
gene id: 27291:SPAR_E02140
uniprot id: A0A8B8UQB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RPAP2 family.
messages: Nucleus
messages: Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.

27291:SPAR J01140
gene id: 27291:SPAR_J01140
uniprot id: A0A8B8UTW3
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

27291:SPAR K02450
gene id: 27291:SPAR_K02450
uniprot id: A0A8B8UV74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

27291:SPAR P01160
gene id: 27291:SPAR_P01160
uniprot id: A0A8B8V0W4
names: Similarity
messages: Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.

27291:SPAR G00560
gene id: 27291:SPAR_G00560
uniprot id: A0A8B8UR10
names: Similarity
messages: Belongs to the peptidase S10 family.

27291:SPAR K02870
gene id: 27291:SPAR_K02870
uniprot id: A0A8B8UVA3
names: Subcellular Location Annotation
messages: Cytoplasm

27291:SPAR O04800
gene id: 27291:SPAR_O04800
uniprot id: A0A8B8V0E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferric reductase (FRE) family.
messages: Cell membrane
messages: Membrane

27291:SPAR O04050
gene id: 27291:SPAR_O04050
uniprot id: A0A8B8V068
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: Nucleus

27291:SPAR O01100
gene id: 27291:SPAR_O01100
uniprot id: A0A8B8UZB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM RBM34 family.
messages: Involved in pre-25S rRNA processing.
messages: nucleolus

27291:SPAR N01920
gene id: 27291:SPAR_N01920
uniprot id: A0A8B8UYI0
names: Similarity
messages: Belongs to the peptidase S1C family.

27291:SPAR J01050
gene id: 27291:SPAR_J01050
uniprot id: A0A8B8UTT6
names: Similarity
messages: Belongs to the glutamate--cysteine ligase type 3 family.

27291:SPAR D02040
gene id: 27291:SPAR_D02040
uniprot id: A0A8B8UN98
names: Similarity
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

27291:SPAR I01440
gene id: 27291:SPAR_I01440
uniprot id: A0A8B8UTF6
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR O03320
gene id: 27291:SPAR_O03320
uniprot id: A0A8B8V044
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

27291:SPAR C01130
gene id: 27291:SPAR_C01130
uniprot id: A0A8B8UMI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RAD18 family.
messages: E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.
messages: Interacts with E2 UBC2, forming a complex with ubiquitin ligase activity.
messages: Nucleus

27291:SPAR D00970
gene id: 27291:SPAR_D00970
uniprot id: A0A8B8UMW9
names: Similarity
messages: Belongs to the biotin--protein ligase family.

27291:SPAR E00420
gene id: 27291:SPAR_E00420
uniprot id: A0A8B8UPT2
names: Similarity
messages: Belongs to the pyridoxine kinase family.

27291:SPAR P01900
gene id: 27291:SPAR_P01900
uniprot id: A0A8B8V103
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase B chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane

27291:SPAR D03240
gene id: 27291:SPAR_D03240
uniprot id: A0A8B8UNL9
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

27291:SPAR L01360
gene id: 27291:SPAR_L01360
uniprot id: A0A8B8UVR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

27291:SPAR G04780
gene id: 27291:SPAR_G04780
uniprot id: A0A8B8US36
names: Similarity
messages: Belongs to the EFG1 family.

27291:SPAR B02830
gene id: 27291:SPAR_B02830
uniprot id: A0A8B8UMA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Membrane

27291:SPAR D00710
gene id: 27291:SPAR_D00710
uniprot id: A0A8B8UMW2
names: Cofactor
names: Similarity
messages: Belongs to the glutamate synthase family.
messages: Binds 1 [3Fe-4S] cluster.

27291:SPAR L03190
gene id: 27291:SPAR_L03190
uniprot id: A0A8B8UWE1
names: Similarity
messages: Belongs to the glycosyl hydrolase 5 (cellulase A) family.

27291:SPAR C01420
gene id: 27291:SPAR_C01420
uniprot id: A0A8B8UMN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
messages: Membrane

27291:SPAR D06310
gene id: 27291:SPAR_D06310
uniprot id: A0A8B8UPH7
names: Similarity
messages: Belongs to the universal ribosomal protein uS13 family.

27291:SPAR K00320
gene id: 27291:SPAR_K00320
uniprot id: A0A8B8UUK2
names: Similarity
messages: Belongs to the Mo25 family.

27291:SPAR H02330
gene id: 27291:SPAR_H02330
uniprot id: A0A8B8USU6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum membrane
messages: Plays a role in determining ER morphology.
messages: The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.

27291:SPAR L00110
gene id: 27291:SPAR_L00110
uniprot id: A0A8B8UVD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR I01840
gene id: 27291:SPAR_I01840
uniprot id: A0A8B8UTI9
names: Similarity
messages: Belongs to the allantoicase family.

27291:SPAR D00410
gene id: 27291:SPAR_D00410
uniprot id: A0A8B8UMT3
names: Similarity
messages: Belongs to the HMBS family.

27291:SPAR B03060
gene id: 27291:SPAR_B03060
uniprot id: A0A8B8UM02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

27291:A560 mgp08
gene id: 27291:A560_mgp08
uniprot id: I1Z683
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

27291:SPAR E00590
gene id: 27291:SPAR_E00590
uniprot id: A0A8B8UPV6
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

27291:SPAR L02380
gene id: 27291:SPAR_L02380
uniprot id: A0A8B8UW17
names: Similarity
messages: Belongs to the epsin family.

27291:SPAR K02980
gene id: 27291:SPAR_K02980
uniprot id: A0A8B8UVH0
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

27291:SPAR C00920
gene id: 27291:SPAR_C00920
uniprot id: A0A8B8UMI3
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR G04720
gene id: 27291:SPAR_G04720
uniprot id: A0A8B8US71
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

27291:SPAR D02910
gene id: 27291:SPAR_D02910
uniprot id: A0A8B8UNH9
names: Similarity
messages: Belongs to the PPP phosphatase family.

27291:SPAR H01910
gene id: 27291:SPAR_H01910
uniprot id: A0A8B8USV7
names: Subcellular Location Annotation
messages: Membrane
messages: Peroxisome membrane

27291:SPAR J02270
gene id: 27291:SPAR_J02270
uniprot id: A0A8B8UU63
names: Similarity
messages: Belongs to the heat shock protein 70 family.

27291:SPAR H00260
gene id: 27291:SPAR_H00260
uniprot id: A0A8B8USC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

27291:SPAR M03330
gene id: 27291:SPAR_M03330
uniprot id: A0A8B8UXM7
names: Subunit
messages: Homodimer.

27291:SPAR E00680
gene id: 27291:SPAR_E00680
uniprot id: A0A8B8UQ66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDOST 48 kDa subunit family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).

27291:SPAR I00700
gene id: 27291:SPAR_I00700
uniprot id: A0A8B8UT47
names: Similarity
messages: Belongs to the glycosyl hydrolase 15 family.

27291:SPAR D01190
gene id: 27291:SPAR_D01190
uniprot id: A0A8B8UN13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: Membrane
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.
messages: Mitochondrion inner membrane

27291:SPAR M01600
gene id: 27291:SPAR_M01600
uniprot id: A0A8B8UX55
names: Function
names: Similarity
messages: Belongs to the MPI phosphatase family.
messages: Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle.

27291:SPAR D06500
gene id: 27291:SPAR_D06500
uniprot id: A0A8B8UPI6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL27 family.

27291:SPAR M00010
gene id: 27291:SPAR_M00010
uniprot id: A0A8B8UWT5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

27291:SPAR O03620
gene id: 27291:SPAR_O03620
uniprot id: A0A8B8V075
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

27291:SPAR G04580
gene id: 27291:SPAR_G04580
uniprot id: A0A8B8US17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

27291:SPAR O03870
gene id: 27291:SPAR_O03870
uniprot id: A0A8B8V0A0
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR O02060
gene id: 27291:SPAR_O02060
uniprot id: A0A8B8UZM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

27291:SPAR M01030
gene id: 27291:SPAR_M01030
uniprot id: A0A8B8UWZ4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

27291:SPAR B00570
gene id: 27291:SPAR_B00570
uniprot id: A0A8B8UL55
names: Similarity
messages: Belongs to the yippee family.

27291:SPAR L02680
gene id: 27291:SPAR_L02680
uniprot id: A0A8B8UW48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

27291:SPAR B00100
gene id: 27291:SPAR_B00100
uniprot id: A0A8B8UL61
names: Similarity
messages: Belongs to the WD repeat mio family.

27291:SPAR D05120
gene id: 27291:SPAR_D05120
uniprot id: A0A8B8UP35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DASH complex DAD4 family.
messages: Nucleus
messages: kinetochore
messages: spindle

27291:SPAR B01250
gene id: 27291:SPAR_B01250
uniprot id: A0A8B8ULI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

27291:SPAR B03400
gene id: 27291:SPAR_B03400
uniprot id: A0A8B8UM48
names: Similarity
messages: Belongs to the glutathione peroxidase family.

27291:SPAR N01610
gene id: 27291:SPAR_N01610
uniprot id: A0A8B8UYE8
names: Function
names: Similarity
messages: Belongs to the endosulfine family.
messages: Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.

27291:SPAR B01750
gene id: 27291:SPAR_B01750
uniprot id: A0A8B8ULN2
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

27291:SPAR E00700
gene id: 27291:SPAR_E00700
uniprot id: A0A8B8UPY1
names: Similarity
messages: Belongs to the MNN1/MNT family.

27291:SPAR P00170
gene id: 27291:SPAR_P00170
uniprot id: A0A8B8V0H1
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.

27291:SPAR L04070
gene id: 27291:SPAR_L04070
uniprot id: A0A8B8UWP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. SKI2 subfamily.
messages: Cytoplasm

27291:SPAR N02750
gene id: 27291:SPAR_N02750
uniprot id: A0A8B8UYR4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H3 family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

27291:SPAR G03770
gene id: 27291:SPAR_G03770
uniprot id: A0A8B8URY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Component of the GSE complex.
messages: GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.

27291:SPAR D02880
gene id: 27291:SPAR_D02880
uniprot id: A0A8B8UNU4
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR H01030
gene id: 27291:SPAR_H01030
uniprot id: A0A8B8USQ3
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

27291:SPAR I00980
gene id: 27291:SPAR_I00980
uniprot id: A0A8B8UTC6
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

27291:SPAR B02900
gene id: 27291:SPAR_B02900
uniprot id: A0A8B8ULZ5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

27291:SPAR E00170
gene id: 27291:SPAR_E00170
uniprot id: A0A8B8UPQ6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.

27291:SPAR G02720
gene id: 27291:SPAR_G02720
uniprot id: A0A8B8URM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Mitochondrion inner membrane

27291:SPAR C00420
gene id: 27291:SPAR_C00420
uniprot id: A0A8B8UMD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
messages: Membrane

27291:SPAR D03050
gene id: 27291:SPAR_D03050
uniprot id: A0A8B8UNJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SLU7 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

27291:SPAR L00500
gene id: 27291:SPAR_L00500
uniprot id: A0A8B8UVN4
names: Similarity
messages: Belongs to the DEAD box helicase family.

27291:SPAR O01920
gene id: 27291:SPAR_O01920
uniprot id: A0A8B8UZQ3
names: Similarity
messages: Belongs to the ETT1 family.

27291:SPAR C00260
gene id: 27291:SPAR_C00260
uniprot id: A0A8B8UMB9
names: Similarity
messages: Belongs to the hexokinase family.

27291:SPAR M02360
gene id: 27291:SPAR_M02360
uniprot id: A0A8B8UXH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PurH family.
messages: cytosol

27291:SPAR J00890
gene id: 27291:SPAR_J00890
uniprot id: A0A8B8UTT5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

27291:SPAR N03350
gene id: 27291:SPAR_N03350
uniprot id: A0A8B8UYX5
names: Similarity
messages: In the C-terminal section; belongs to the anthranilate synthase component I family.

27291:SPAR M03080
gene id: 27291:SPAR_M03080
uniprot id: A0A8B8UXK2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

27291:SPAR L03210
gene id: 27291:SPAR_L03210
uniprot id: A0A8B8UWA1
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

27291:SPAR O01450
gene id: 27291:SPAR_O01450
uniprot id: A0A8B8UZF4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.
messages: Endoplasmic reticulum membrane
messages: Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

27291:SPAR E01580
gene id: 27291:SPAR_E01580
uniprot id: A0A8B8UQF1
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

27291:SPAR O03470
gene id: 27291:SPAR_O03470
uniprot id: A0A8B8V059
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NifU family.
messages: Mitochondrion matrix
messages: Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.

27291:SPAR P01210
gene id: 27291:SPAR_P01210
uniprot id: A0A8B8V0W8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTPA-type PPIase family.
messages: Cytoplasm
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

27291:SPAR H00670
gene id: 27291:SPAR_H00670
uniprot id: A0A8B8USD5
names: Similarity
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.

27291:SPAR K01120
gene id: 27291:SPAR_K01120
uniprot id: A0A8B8UUS9
names: Similarity
messages: Belongs to the peptidase A22B family.

27291:SPAR O01530
gene id: 27291:SPAR_O01530
uniprot id: A0A8B8UZG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Nucleus

27291:SPAR J02710
gene id: 27291:SPAR_J02710
uniprot id: A0A8B8UUG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIP1 family.
messages: Nucleus

27291:SPAR D00260
gene id: 27291:SPAR_D00260
uniprot id: A0A8B8UMR6
names: Subcellular Location Annotation
messages: telomere

27291:SPAR M01510
gene id: 27291:SPAR_M01510
uniprot id: A0A8B8UX94
names: Domain
names: Function
names: Similarity
messages: Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.
messages: Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.
messages: Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.

27291:SPAR O02600
gene id: 27291:SPAR_O02600
uniprot id: A0A8B8UZR9
names: Similarity
messages: In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.

27291:SPAR L00980
gene id: 27291:SPAR_L00980
uniprot id: A0A8B8UVM5
names: Similarity
messages: Belongs to the thioredoxin family.

27291:SPAR G00600
gene id: 27291:SPAR_G00600
uniprot id: A0A8B8UQY0
names: Similarity
messages: Belongs to the DSD1 family.

27291:SPAR O00610
gene id: 27291:SPAR_O00610
uniprot id: A0A8B8UZ76
names: Subcellular Location Annotation
messages: Membrane

27291:SPAR B00360
gene id: 27291:SPAR_B00360
uniprot id: A0A8B8UQ86
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS8 family.

27291:SPAR M01080
gene id: 27291:SPAR_M01080
uniprot id: A0A8B8UWZ9
names: Subcellular Location Annotation
messages: Membrane