2690837:GS424 RS17620
gene id: 2690837:GS424_RS17620
uniprot id: A0A6N7RKA9
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

2690837:GS424 RS01865
gene id: 2690837:GS424_RS01865
uniprot id: A0A6L7IS75
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

2690837:GS424 RS08505
gene id: 2690837:GS424_RS08505
uniprot id: A0A6N7RJS4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

2690837:GS424 RS04850
gene id: 2690837:GS424_RS04850
uniprot id: A0A6N7RR49
names: Similarity
messages: Belongs to the UPF0473 family.

2690837:GS424 RS04960
gene id: 2690837:GS424_RS04960
uniprot id: A0A6L7IUB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

2690837:GS424 RS04750
gene id: 2690837:GS424_RS04750
uniprot id: A0A6N7RS90
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

2690837:GS424 RS08395
gene id: 2690837:GS424_RS08395
uniprot id: A0A6L7ITN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

2690837:GS424 RS15420
gene id: 2690837:GS424_RS15420
uniprot id: A0A6L7IQX8
names: Subcellular Location Annotation
messages: Membrane

2690837:GS424 RS11465
gene id: 2690837:GS424_RS11465
uniprot id: A0A6N7RQZ1
names: Similarity
messages: Belongs to the glutamine synthetase family.

2690837:GS424 RS12395
gene id: 2690837:GS424_RS12395
uniprot id: A0A6L7ITQ9
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

2690837:GS424 RS10640
gene id: 2690837:GS424_RS10640
uniprot id: A0A6N7RJS6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

2690837:GS424 RS15290
gene id: 2690837:GS424_RS15290
uniprot id: A0A6L7IPB2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2690837:GS424 RS12375
gene id: 2690837:GS424_RS12375
uniprot id: A0A6N7RNY2
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

2690837:GS424 RS16010
gene id: 2690837:GS424_RS16010
uniprot id: A0A6N7RLV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

2690837:GS424 RS05105
gene id: 2690837:GS424_RS05105
uniprot id: A0A6N7RQ28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

2690837:GS424 RS16020
gene id: 2690837:GS424_RS16020
uniprot id: A0A6N7RKX2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

2690837:GS424 RS04875
gene id: 2690837:GS424_RS04875
uniprot id: A0A6L7IW74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).

2690837:GS424 RS04800
gene id: 2690837:GS424_RS04800
uniprot id: A0A6L7ITV0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

2690837:GS424 RS13255
gene id: 2690837:GS424_RS13255
uniprot id: A0A6L7ITA0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

2690837:GS424 RS12525
gene id: 2690837:GS424_RS12525
uniprot id: A0A6L7ITC2
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

2690837:GS424 RS11530
gene id: 2690837:GS424_RS11530
uniprot id: A0A6L7IVC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2690837:GS424 RS04705
gene id: 2690837:GS424_RS04705
uniprot id: A0A6L7IY93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

2690837:GS424 RS05580
gene id: 2690837:GS424_RS05580
uniprot id: A0A6L7IUM6
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

2690837:GS424 RS07390
gene id: 2690837:GS424_RS07390
uniprot id: A0A6N7RP73
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

2690837:GS424 RS15295
gene id: 2690837:GS424_RS15295
uniprot id: A0A6L7ISR5
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine.

2690837:GS424 RS03405
gene id: 2690837:GS424_RS03405
uniprot id: A0A6N7RSC6
names: Similarity
messages: Belongs to the DtxR/MntR family.

2690837:GS424 RS03030
gene id: 2690837:GS424_RS03030
uniprot id: A0A6L7IWN1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

2690837:GS424 RS04885
gene id: 2690837:GS424_RS04885
uniprot id: A0A6N7RT16
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family.
messages: Cell membrane
messages: Membrane
messages: Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex.

2690837:GS424 RS01855
gene id: 2690837:GS424_RS01855
uniprot id: A0A6L7IT42
names: Similarity
messages: Belongs to the DtxR/MntR family.

2690837:GS424 RS03925
gene id: 2690837:GS424_RS03925
uniprot id: A0A6L7IZQ5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

2690837:GS424 RS11210
gene id: 2690837:GS424_RS11210
uniprot id: A0A6N7RQN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

2690837:GS424 RS04745
gene id: 2690837:GS424_RS04745
uniprot id: A0A6N7RR83
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

2690837:GS424 RS12455
gene id: 2690837:GS424_RS12455
uniprot id: A0A6N7RNT2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

2690837:GS424 RS12460
gene id: 2690837:GS424_RS12460
uniprot id: A0A6N7RQH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

2690837:GS424 RS06355
gene id: 2690837:GS424_RS06355
uniprot id: A0A6L7IV18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

2690837:GS424 RS04780
gene id: 2690837:GS424_RS04780
uniprot id: A0A6L7IV61
names: Subcellular Location Annotation
messages: Cytoplasm

2690837:GS424 RS01795
gene id: 2690837:GS424_RS01795
uniprot id: A0A6L7IR24
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

2690837:GS424 RS04990
gene id: 2690837:GS424_RS04990
uniprot id: A0A6L7IXU4
names: Similarity
messages: Belongs to the ABC transporter superfamily.

2690837:GS424 RS00835
gene id: 2690837:GS424_RS00835
uniprot id: A0A6L7ITT9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arginine deiminase family.
messages: Cytoplasm

2690837:GS424 RS12445
gene id: 2690837:GS424_RS12445
uniprot id: A0A6N7RPX3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

2690837:GS424 RS01985
gene id: 2690837:GS424_RS01985
uniprot id: A0A6N7RMN1
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

2690837:GS424 RS03935
gene id: 2690837:GS424_RS03935
uniprot id: A0A6N7RSH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

2690837:GS424 RS15810
gene id: 2690837:GS424_RS15810
uniprot id: A0A6N7RLP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

2690837:GS424 RS13120
gene id: 2690837:GS424_RS13120
uniprot id: A0A6L7IU90
names: Similarity
messages: Belongs to the CsoR family.

2690837:GS424 RS07185
gene id: 2690837:GS424_RS07185
uniprot id: A0A6N7RQM8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

2690837:GS424 RS15275
gene id: 2690837:GS424_RS15275
uniprot id: A0A6L7IQV1
names: Similarity
messages: Belongs to the TlyA family.

2690837:GS424 RS00140
gene id: 2690837:GS424_RS00140
uniprot id: A0A6N7RLX1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

2690837:GS424 RS13260
gene id: 2690837:GS424_RS13260
uniprot id: A0A6N7RQ73
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

2690837:GS424 RS12075
gene id: 2690837:GS424_RS12075
uniprot id: A0A6N7RPA9
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

2690837:GS424 RS13305
gene id: 2690837:GS424_RS13305
uniprot id: A0A6N7RNH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.