264636:EXC59 RS04840
gene id: 264636:EXC59_RS04840
uniprot id: A0A449BKP0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

264636:EXC59 RS05870
gene id: 264636:EXC59_RS05870
uniprot id: A0A449BLA0
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

264636:EXC59 RS02905
gene id: 264636:EXC59_RS02905
uniprot id: A0A449BJF1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

264636:EXC59 RS00900
gene id: 264636:EXC59_RS00900
uniprot id: A0A449BIB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

264636:EXC59 RS03300
gene id: 264636:EXC59_RS03300
uniprot id: A0A449BJK2
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

264636:EXC59 RS05330
gene id: 264636:EXC59_RS05330
uniprot id: A0A449BKN3
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

264636:EXC59 RS00990
gene id: 264636:EXC59_RS00990
uniprot id: A0A449BIA4
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

264636:EXC59 RS01475
gene id: 264636:EXC59_RS01475
uniprot id: A0A449BIK3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

264636:EXC59 RS04620
gene id: 264636:EXC59_RS04620
uniprot id: A0A449BKB3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

264636:EXC59 RS03415
gene id: 264636:EXC59_RS03415
uniprot id: A0A449BJP2
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

264636:EXC59 RS01670
gene id: 264636:EXC59_RS01670
uniprot id: A0A449BIN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

264636:EXC59 RS01085
gene id: 264636:EXC59_RS01085
uniprot id: A0A449BIE5
names: Function
names: Similarity
messages: Belongs to the NanE family.
messages: Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).

264636:EXC59 RS04575
gene id: 264636:EXC59_RS04575
uniprot id: A0A449BKD9
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

264636:EXC59 RS00795
gene id: 264636:EXC59_RS00795
uniprot id: A0A449BI64
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

264636:EXC59 RS06155
gene id: 264636:EXC59_RS06155
uniprot id: A0A449BL42
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

264636:EXC59 RS04470
gene id: 264636:EXC59_RS04470
uniprot id: A0A449BKC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

264636:EXC59 RS01210
gene id: 264636:EXC59_RS01210
uniprot id: A0A449BIE7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

264636:EXC59 RS03710
gene id: 264636:EXC59_RS03710
uniprot id: A0A449BJV5
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

264636:EXC59 RS01555
gene id: 264636:EXC59_RS01555
uniprot id: A0A449BIK8
names: Function
names: Similarity
messages: Belongs to the RecD family. RecD-like subfamily.
messages: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.

264636:EXC59 RS00570
gene id: 264636:EXC59_RS00570
uniprot id: A0A449BI31
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

264636:EXC59 RS04645
gene id: 264636:EXC59_RS04645
uniprot id: A0A449BKC5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

264636:EXC59 RS05345
gene id: 264636:EXC59_RS05345
uniprot id: A0A449BKS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA which binds and tethers DNA polymerases and other proteins to the DNA. The DNA replisome complex has a single clamp-loading complex (3 tau and 1 each of delta, delta', psi and chi subunits) which binds 3 Pol III cores (1 core on the leading strand and 2 on the lagging strand) each with a beta sliding clamp dimer. Additional proteins in the replisome are other copies of gamma, psi and chi, Ssb, DNA helicase and RNA primase.

264636:EXC59 RS01860
gene id: 264636:EXC59_RS01860
uniprot id: A0A449BIU8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

264636:EXC59 RS00885
gene id: 264636:EXC59_RS00885
uniprot id: A0A449BI87
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

264636:EXC59 RS06185
gene id: 264636:EXC59_RS06185
uniprot id: A0A449BLA8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

264636:EXC59 RS02575
gene id: 264636:EXC59_RS02575
uniprot id: A0A449BJ84
names: Similarity
messages: Belongs to the thioredoxin family.

264636:EXC59 RS04015
gene id: 264636:EXC59_RS04015
uniprot id: A0A449BJZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

264636:EXC59 RS03565
gene id: 264636:EXC59_RS03565
uniprot id: A0A449BJS3
names: Subcellular Location Annotation
messages: Membrane

264636:EXC59 RS02475
gene id: 264636:EXC59_RS02475
uniprot id: A0A449BJ47
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

264636:EXC59 RS04730
gene id: 264636:EXC59_RS04730
uniprot id: A0A449BKM1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

264636:EXC59 RS00820
gene id: 264636:EXC59_RS00820
uniprot id: A0A449BI77
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

264636:EXC59 RS01795
gene id: 264636:EXC59_RS01795
uniprot id: A0A449BIR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

264636:EXC59 RS03105
gene id: 264636:EXC59_RS03105
uniprot id: A0A449BJJ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

264636:EXC59 RS05460
gene id: 264636:EXC59_RS05460
uniprot id: A0A449BL46
names: Similarity
messages: Belongs to the RpoE family.

264636:EXC59 RS01760
gene id: 264636:EXC59_RS01760
uniprot id: A0A449BIS8
names: Caution
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

264636:EXC59 RS03375
gene id: 264636:EXC59_RS03375
uniprot id: A0A449BJL7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

264636:EXC59 RS04940
gene id: 264636:EXC59_RS04940
uniprot id: A0A449BKR0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

264636:EXC59 RS01820
gene id: 264636:EXC59_RS01820
uniprot id: A0A449BIR5
names: Subcellular Location Annotation
messages: Membrane

264636:EXC59 RS04685
gene id: 264636:EXC59_RS04685
uniprot id: A0A449BKF4
names: Function
names: Similarity
messages: Belongs to the sigma-70 factor family.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Sigma-S contributes to the protection against external stress, thus playing a role in cellular fitness and survival.

264636:EXC59 RS02900
gene id: 264636:EXC59_RS02900
uniprot id: A0A449BJR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

264636:EXC59 RS01220
gene id: 264636:EXC59_RS01220
uniprot id: A0A449BIF0
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

264636:EXC59 RS06165
gene id: 264636:EXC59_RS06165
uniprot id: A0A449BL99
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

264636:EXC59 RS02870
gene id: 264636:EXC59_RS02870
uniprot id: A0A449BJC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

264636:EXC59 RS01745
gene id: 264636:EXC59_RS01745
uniprot id: A0A449BIS7
names: Subcellular Location Annotation
messages: Membrane

264636:EXC59 RS02680
gene id: 264636:EXC59_RS02680
uniprot id: A0A449BJ88
names: Subcellular Location Annotation
messages: Membrane

264636:EXC59 RS02590
gene id: 264636:EXC59_RS02590
uniprot id: A0A449BJ64
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

264636:EXC59 RS06530
gene id: 264636:EXC59_RS06530
uniprot id: A0A449BLD5
names: Similarity
messages: Belongs to the pirin family.

264636:EXC59 RS01205
gene id: 264636:EXC59_RS01205
uniprot id: A0A449BIK4
names: Subcellular Location Annotation
messages: Membrane

264636:EXC59 RS00245
gene id: 264636:EXC59_RS00245
uniprot id: A0A449BHW6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

264636:EXC59 RS04945
gene id: 264636:EXC59_RS04945
uniprot id: A0A449BKL6
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

264636:EXC59 RS03305
gene id: 264636:EXC59_RS03305
uniprot id: A0A449BJZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

264636:EXC59 RS06585
gene id: 264636:EXC59_RS06585
uniprot id: A0A449BLG0
names: Similarity
messages: Belongs to the AlaDH/PNT family.

264636:EXC59 RS00815
gene id: 264636:EXC59_RS00815
uniprot id: A0A449BI81
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

264636:EXC59 RS04335
gene id: 264636:EXC59_RS04335
uniprot id: A0A449BKC7
names: Similarity
messages: Belongs to the peptidase M29 family.

264636:EXC59 RS03765
gene id: 264636:EXC59_RS03765
uniprot id: A0A449BJZ7
names: Similarity
messages: Belongs to the CvfB family.

264636:EXC59 RS00510
gene id: 264636:EXC59_RS00510
uniprot id: A0A449BI19
names: Subcellular Location Annotation
messages: Membrane

264636:EXC59 RS05105
gene id: 264636:EXC59_RS05105
uniprot id: A0A449BKL0
names: Similarity
messages: Belongs to the transketolase family.

264636:EXC59 RS04905
gene id: 264636:EXC59_RS04905
uniprot id: A0A449BKH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

264636:EXC59 RS04745
gene id: 264636:EXC59_RS04745
uniprot id: A0A449BKE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

264636:EXC59 RS00875
gene id: 264636:EXC59_RS00875
uniprot id: A0A449BIK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

264636:EXC59 RS04640
gene id: 264636:EXC59_RS04640
uniprot id: A0A449BKB5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

264636:EXC59 RS06275
gene id: 264636:EXC59_RS06275
uniprot id: A0A449BL91
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

264636:EXC59 RS04560
gene id: 264636:EXC59_RS04560
uniprot id: A0A449BKC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.
messages: Cell membrane

264636:EXC59 RS04615
gene id: 264636:EXC59_RS04615
uniprot id: A0A449BKF8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

264636:EXC59 RS00935
gene id: 264636:EXC59_RS00935
uniprot id: A0A449BI97
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

264636:EXC59 RS00095
gene id: 264636:EXC59_RS00095
uniprot id: A0A449BHT1
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

264636:EXC59 RS04360
gene id: 264636:EXC59_RS04360
uniprot id: A0A449BK82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

264636:EXC59 RS02170
gene id: 264636:EXC59_RS02170
uniprot id: A0A449BIY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

264636:EXC59 RS00750
gene id: 264636:EXC59_RS00750
uniprot id: A0A449BI79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

264636:EXC59 RS02580
gene id: 264636:EXC59_RS02580
uniprot id: A0A449BJD5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

264636:EXC59 RS06855
gene id: 264636:EXC59_RS06855
uniprot id: A0A449BLK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

264636:EXC59 RS02940
gene id: 264636:EXC59_RS02940
uniprot id: A0A449BJD3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

264636:EXC59 RS05400
gene id: 264636:EXC59_RS05400
uniprot id: A0A449BKP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

264636:EXC59 RS05360
gene id: 264636:EXC59_RS05360
uniprot id: A0A449BL26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

264636:EXC59 RS04835
gene id: 264636:EXC59_RS04835
uniprot id: A0A449BKJ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

264636:EXC59 RS00760
gene id: 264636:EXC59_RS00760
uniprot id: A0A449BI61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

264636:EXC59 RS02685
gene id: 264636:EXC59_RS02685
uniprot id: A0A449BJ85
names: Similarity
messages: Belongs to the band 7/mec-2 family.

264636:EXC59 RS03995
gene id: 264636:EXC59_RS03995
uniprot id: A0A449BKC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

264636:EXC59 RS01320
gene id: 264636:EXC59_RS01320
uniprot id: A0A449BIH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

264636:EXC59 RS04935
gene id: 264636:EXC59_RS04935
uniprot id: A0A449BKL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

264636:EXC59 RS03190
gene id: 264636:EXC59_RS03190
uniprot id: A0A449BJI3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

264636:EXC59 RS01225
gene id: 264636:EXC59_RS01225
uniprot id: A0A449BIU2
names: Subcellular Location Annotation
messages: Membrane

264636:EXC59 RS01490
gene id: 264636:EXC59_RS01490
uniprot id: A0A449BIM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

264636:EXC59 RS01965
gene id: 264636:EXC59_RS01965
uniprot id: A0A449BJ02
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

264636:EXC59 RS05470
gene id: 264636:EXC59_RS05470
uniprot id: A0A449BKT2
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

264636:EXC59 RS01715
gene id: 264636:EXC59_RS01715
uniprot id: A0A449BIU9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

264636:EXC59 RS05380
gene id: 264636:EXC59_RS05380
uniprot id: A0A449BKP6
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

264636:EXC59 RS03700
gene id: 264636:EXC59_RS03700
uniprot id: A0A449BK70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

264636:EXC59 RS04790
gene id: 264636:EXC59_RS04790
uniprot id: A0A449BKH2
names: Subcellular Location Annotation
messages: Membrane

264636:EXC59 RS06195
gene id: 264636:EXC59_RS06195
uniprot id: A0A449BL53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

264636:EXC59 RS01410
gene id: 264636:EXC59_RS01410
uniprot id: A0A449BIP2
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

264636:EXC59 RS04880
gene id: 264636:EXC59_RS04880
uniprot id: A0A449BKG7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

264636:EXC59 RS01800
gene id: 264636:EXC59_RS01800
uniprot id: A0A449BIT5
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

264636:EXC59 RS02700
gene id: 264636:EXC59_RS02700
uniprot id: A0A449BJA9
names: Similarity
messages: Belongs to the UDPGP type 2 family.

264636:EXC59 RS05550
gene id: 264636:EXC59_RS05550
uniprot id: A0A449BKW5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

264636:EXC59 RS04865
gene id: 264636:EXC59_RS04865
uniprot id: A0A449BKI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

264636:EXC59 RS02255
gene id: 264636:EXC59_RS02255
uniprot id: A0A449BIZ5
names: Subcellular Location Annotation
messages: Membrane

264636:EXC59 RS05635
gene id: 264636:EXC59_RS05635
uniprot id: A0A449BKY8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

264636:EXC59 RS04580
gene id: 264636:EXC59_RS04580
uniprot id: A0A449BKH9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

264636:EXC59 RS05265
gene id: 264636:EXC59_RS05265
uniprot id: A0A449BKM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

264636:EXC59 RS02865
gene id: 264636:EXC59_RS02865
uniprot id: A0A449BJF5
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

264636:EXC59 RS04625
gene id: 264636:EXC59_RS04625
uniprot id: A0A449BKF0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

264636:EXC59 RS04875
gene id: 264636:EXC59_RS04875
uniprot id: A0A449BKL3
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

264636:EXC59 RS05260
gene id: 264636:EXC59_RS05260
uniprot id: A0A449BL08
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

264636:EXC59 RS05630
gene id: 264636:EXC59_RS05630
uniprot id: A0A449BKU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein bS18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm

264636:EXC59 RS01165
gene id: 264636:EXC59_RS01165
uniprot id: A0A449BIE8
names: Similarity
messages: Belongs to the AHA1 family.

264636:EXC59 RS04825
gene id: 264636:EXC59_RS04825
uniprot id: A0A449BKJ5
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

264636:EXC59 RS00270
gene id: 264636:EXC59_RS00270
uniprot id: A0A449BHW8
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

264636:EXC59 RS02745
gene id: 264636:EXC59_RS02745
uniprot id: A0A449BJN3
names: Similarity
messages: Belongs to the peptidase M24B family.

264636:EXC59 RS00505
gene id: 264636:EXC59_RS00505
uniprot id: A0A449BI29
names: Subcellular Location Annotation
messages: Membrane

264636:EXC59 RS04315
gene id: 264636:EXC59_RS04315
uniprot id: A0A449BK76
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

264636:EXC59 RS04610
gene id: 264636:EXC59_RS04610
uniprot id: A0A449BKD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

264636:EXC59 RS05670
gene id: 264636:EXC59_RS05670
uniprot id: A0A449BKX2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

264636:EXC59 RS01450
gene id: 264636:EXC59_RS01450
uniprot id: A0A449BII8
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

264636:EXC59 RS01505
gene id: 264636:EXC59_RS01505
uniprot id: A0A449BIJ8
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

264636:EXC59 RS02955
gene id: 264636:EXC59_RS02955
uniprot id: A0A449BJG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

264636:EXC59 RS04505
gene id: 264636:EXC59_RS04505
uniprot id: A0A449BKB8
names: Similarity
messages: Belongs to the IMPACT family.

264636:EXC59 RS05130
gene id: 264636:EXC59_RS05130
uniprot id: A0A449BKP1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL31 family.

264636:EXC59 RS06960
gene id: 264636:EXC59_RS06960
uniprot id: A0A449BLM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

264636:EXC59 RS03680
gene id: 264636:EXC59_RS03680
uniprot id: A0A449BJU5
names: Subcellular Location Annotation
messages: Membrane

264636:EXC59 RS05175
gene id: 264636:EXC59_RS05175
uniprot id: A0A449BKK6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
messages: The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.

264636:EXC59 RS03080
gene id: 264636:EXC59_RS03080
uniprot id: A0A449BJN6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

264636:EXC59 RS03325
gene id: 264636:EXC59_RS03325
uniprot id: A0A449BJK7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

264636:EXC59 RS01915
gene id: 264636:EXC59_RS01915
uniprot id: A0A449BIZ1
names: Similarity
messages: Belongs to the dihydrofolate reductase family.

264636:EXC59 RS04460
gene id: 264636:EXC59_RS04460
uniprot id: A0A449BKA9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

264636:EXC59 RS03640
gene id: 264636:EXC59_RS03640
uniprot id: A0A449BJS2
names: Similarity
messages: Belongs to the acetyl-CoA hydrolase/transferase family.

264636:EXC59 RS04245
gene id: 264636:EXC59_RS04245
uniprot id: A0A449BK34
names: Cofactor
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.

264636:EXC59 RS00695
gene id: 264636:EXC59_RS00695
uniprot id: A0A449BI43
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

264636:EXC59 RS00880
gene id: 264636:EXC59_RS00880
uniprot id: A0A449BI98
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 2 family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

264636:EXC59 RS05540
gene id: 264636:EXC59_RS05540
uniprot id: A0A449BKW4
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

264636:EXC59 RS04670
gene id: 264636:EXC59_RS04670
uniprot id: A0A449BKC4
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

264636:EXC59 RS04855
gene id: 264636:EXC59_RS04855
uniprot id: A0A449BKG5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

264636:EXC59 RS03230
gene id: 264636:EXC59_RS03230
uniprot id: A0A449BJK1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

264636:EXC59 RS00495
gene id: 264636:EXC59_RS00495
uniprot id: A0A449BI51
names: Similarity
messages: Belongs to the BMP lipoprotein family.

264636:EXC59 RS00675
gene id: 264636:EXC59_RS00675
uniprot id: A0A449BI58
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

264636:EXC59 RS04950
gene id: 264636:EXC59_RS04950
uniprot id: A0A449BKH4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

264636:EXC59 RS03365
gene id: 264636:EXC59_RS03365
uniprot id: A0A449BJN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm

264636:EXC59 RS03165
gene id: 264636:EXC59_RS03165
uniprot id: A0A449BJL9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

264636:EXC59 RS04850
gene id: 264636:EXC59_RS04850
uniprot id: A0A449BKF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

264636:EXC59 RS04925
gene id: 264636:EXC59_RS04925
uniprot id: A0A449BKM0
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

264636:EXC59 RS04380
gene id: 264636:EXC59_RS04380
uniprot id: A0A449BK95
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

264636:EXC59 RS04725
gene id: 264636:EXC59_RS04725
uniprot id: A0A449BKH0
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

264636:EXC59 RS06030
gene id: 264636:EXC59_RS06030
uniprot id: A0A449BLA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

264636:EXC59 RS06415
gene id: 264636:EXC59_RS06415
uniprot id: A0A449BLB5
names: Similarity
messages: Belongs to the ClpA/ClpB family.

264636:EXC59 RS06600
gene id: 264636:EXC59_RS06600
uniprot id: A0A449BLF3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

264636:EXC59 RS01610
gene id: 264636:EXC59_RS01610
uniprot id: A0A449BIQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

264636:EXC59 RS02015
gene id: 264636:EXC59_RS02015
uniprot id: A0A449BIX7
names: Subcellular Location Annotation
messages: Membrane

264636:EXC59 RS03625
gene id: 264636:EXC59_RS03625
uniprot id: A0A449BJR8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

264636:EXC59 RS06630
gene id: 264636:EXC59_RS06630
uniprot id: A0A449BLF1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

264636:EXC59 RS02570
gene id: 264636:EXC59_RS02570
uniprot id: A0A449BJ55
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

264636:EXC59 RS05225
gene id: 264636:EXC59_RS05225
uniprot id: A0A449BKQ7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm

264636:EXC59 RS04920
gene id: 264636:EXC59_RS04920
uniprot id: A0A449BKJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

264636:EXC59 RS00040
gene id: 264636:EXC59_RS00040
uniprot id: A0A449BHS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

264636:EXC59 RS01640
gene id: 264636:EXC59_RS01640
uniprot id: A0A449BIQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

264636:EXC59 RS05250
gene id: 264636:EXC59_RS05250
uniprot id: A0A449BKK8
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

264636:EXC59 RS03490
gene id: 264636:EXC59_RS03490
uniprot id: A0A449BJP4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: In the N-terminal section; belongs to the DHBP synthase family.

264636:EXC59 RS02505
gene id: 264636:EXC59_RS02505
uniprot id: A0A449BJ83
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

264636:EXC59 RS03955
gene id: 264636:EXC59_RS03955
uniprot id: A0A449BK03
names: Subcellular Location Annotation
messages: Membrane

264636:EXC59 RS04045
gene id: 264636:EXC59_RS04045
uniprot id: A0A449BKD5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

264636:EXC59 RS02290
gene id: 264636:EXC59_RS02290
uniprot id: A0A449BJ34
names: Cofactor
messages: Binds 2 magnesium ions per subunit.

264636:EXC59 RS01790
gene id: 264636:EXC59_RS01790
uniprot id: A0A449BIT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell membrane
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.

264636:EXC59 RS00905
gene id: 264636:EXC59_RS00905
uniprot id: A0A449BID2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

264636:EXC59 RS03655
gene id: 264636:EXC59_RS03655
uniprot id: A0A449BK63
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

264636:EXC59 RS02910
gene id: 264636:EXC59_RS02910
uniprot id: A0A449BJD0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

264636:EXC59 RS04530
gene id: 264636:EXC59_RS04530
uniprot id: A0A449BKG6
names: Function
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

264636:EXC59 RS04495
gene id: 264636:EXC59_RS04495
uniprot id: A0A449BK94
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

264636:EXC59 RS05385
gene id: 264636:EXC59_RS05385
uniprot id: A0A449BKT5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

264636:EXC59 RS02395
gene id: 264636:EXC59_RS02395
uniprot id: A0A449BJ32
names: Similarity
messages: Belongs to the IS21/IS1162 putative ATP-binding protein family.

264636:EXC59 RS06150
gene id: 264636:EXC59_RS06150
uniprot id: A0A449BL79
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

264636:EXC59 RS03205
gene id: 264636:EXC59_RS03205
uniprot id: A0A449BJX8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

264636:EXC59 RS06725
gene id: 264636:EXC59_RS06725
uniprot id: A0A449BLH6
names: Function
names: Similarity
messages: Belongs to the dTDP-4-dehydrorhamnose reductase family.
messages: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.

264636:EXC59 RS05280
gene id: 264636:EXC59_RS05280
uniprot id: A0A449BKM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

264636:EXC59 RS01825
gene id: 264636:EXC59_RS01825
uniprot id: A0A449BIS1
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

264636:EXC59 RS03170
gene id: 264636:EXC59_RS03170
uniprot id: A0A449BJI0
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

264636:EXC59 RS06215
gene id: 264636:EXC59_RS06215
uniprot id: A0A449BL88
names: Similarity
messages: Belongs to the ArsC family.

264636:EXC59 RS06640
gene id: 264636:EXC59_RS06640
uniprot id: A0A449BLG4
names: Similarity
messages: Belongs to the glutamine synthetase family.

264636:EXC59 RS05315
gene id: 264636:EXC59_RS05315
uniprot id: A0A449BKN2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

264636:EXC59 RS03330
gene id: 264636:EXC59_RS03330
uniprot id: A0A449BJM3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

264636:EXC59 RS01740
gene id: 264636:EXC59_RS01740
uniprot id: A0A449BIQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.
messages: Membrane

264636:EXC59 RS05810
gene id: 264636:EXC59_RS05810
uniprot id: A0A449BKX7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

264636:EXC59 RS06790
gene id: 264636:EXC59_RS06790
uniprot id: A0A449BLK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

264636:EXC59 RS00615
gene id: 264636:EXC59_RS00615
uniprot id: A0A449BIF2
names: Subcellular Location Annotation
messages: Membrane

264636:EXC59 RS05295
gene id: 264636:EXC59_RS05295
uniprot id: A0A449BKR8
names: Function
names: Similarity
messages: Belongs to the PduL family.
messages: Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate.

264636:EXC59 RS01150
gene id: 264636:EXC59_RS01150
uniprot id: A0A449BIG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

264636:EXC59 RS03215
gene id: 264636:EXC59_RS03215
uniprot id: A0A449BJK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

264636:EXC59 RS06620
gene id: 264636:EXC59_RS06620
uniprot id: A0A449BLF9
names: Similarity
messages: Belongs to the polysaccharide synthase family.

264636:EXC59 RS05650
gene id: 264636:EXC59_RS05650
uniprot id: A0A449BKU4
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

264636:EXC59 RS00225
gene id: 264636:EXC59_RS00225
uniprot id: A0A449BHX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

264636:EXC59 RS00110
gene id: 264636:EXC59_RS00110
uniprot id: A0A449BI56
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

264636:EXC59 RS00125
gene id: 264636:EXC59_RS00125
uniprot id: A0A449BHV3
names: Subcellular Location Annotation
messages: Membrane

264636:EXC59 RS01525
gene id: 264636:EXC59_RS01525
uniprot id: A0A449BIL4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

264636:EXC59 RS02885
gene id: 264636:EXC59_RS02885
uniprot id: A0A449BJC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

264636:EXC59 RS05570
gene id: 264636:EXC59_RS05570
uniprot id: A0A449BKV2
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

264636:EXC59 RS06550
gene id: 264636:EXC59_RS06550
uniprot id: A0A449BLE3
names: Similarity
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.

264636:EXC59 RS01550
gene id: 264636:EXC59_RS01550
uniprot id: A0A449BIN8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

264636:EXC59 RS05155
gene id: 264636:EXC59_RS05155
uniprot id: A0A449BKZ0
names: Subcellular Location Annotation
messages: Membrane

264636:EXC59 RS01865
gene id: 264636:EXC59_RS01865
uniprot id: A0A449BIY2
names: Similarity
messages: Belongs to the asparaginase 1 family.

264636:EXC59 RS04870
gene id: 264636:EXC59_RS04870
uniprot id: A0A449BKI1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

264636:EXC59 RS04555
gene id: 264636:EXC59_RS04555
uniprot id: A0A449BKC9
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

264636:EXC59 RS06805
gene id: 264636:EXC59_RS06805
uniprot id: A0A449BLJ2
names: Similarity
messages: Belongs to the N-acylglucosamine 2-epimerase family.

264636:EXC59 RS06070
gene id: 264636:EXC59_RS06070
uniprot id: A0A449BL65
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

264636:EXC59 RS01140
gene id: 264636:EXC59_RS01140
uniprot id: A0A449BIF7
names: Subcellular Location Annotation
messages: Membrane

264636:EXC59 RS04090
gene id: 264636:EXC59_RS04090
uniprot id: A0A449BK10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

264636:EXC59 RS03575
gene id: 264636:EXC59_RS03575
uniprot id: A0A449BJQ8
names: Subcellular Location Annotation
messages: Membrane

264636:EXC59 RS04655
gene id: 264636:EXC59_RS04655
uniprot id: A0A449BKE9
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

264636:EXC59 RS03545
gene id: 264636:EXC59_RS03545
uniprot id: A0A449BJP9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

264636:EXC59 RS02915
gene id: 264636:EXC59_RS02915
uniprot id: A0A449BJG9
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

264636:EXC59 RS00190
gene id: 264636:EXC59_RS00190
uniprot id: A0A449BHZ4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

264636:EXC59 RS02925
gene id: 264636:EXC59_RS02925
uniprot id: A0A449BJE9
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

264636:EXC59 RS00185
gene id: 264636:EXC59_RS00185
uniprot id: A0A449BHX0
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

264636:EXC59 RS05180
gene id: 264636:EXC59_RS05180
uniprot id: A0A449BKP8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

264636:EXC59 RS04830
gene id: 264636:EXC59_RS04830
uniprot id: A0A449BKF6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

264636:EXC59 RS05355
gene id: 264636:EXC59_RS05355
uniprot id: A0A449BKN6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

264636:EXC59 RS04630
gene id: 264636:EXC59_RS04630
uniprot id: A0A449BKI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

264636:EXC59 RS06420
gene id: 264636:EXC59_RS06420
uniprot id: A0A449BLB2
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

264636:EXC59 RS01190
gene id: 264636:EXC59_RS01190
uniprot id: A0A449BIH2
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

264636:EXC59 RS03035
gene id: 264636:EXC59_RS03035
uniprot id: A0A449BJF2
names: Similarity
messages: Belongs to the UPF0473 family.

264636:EXC59 RS03735
gene id: 264636:EXC59_RS03735
uniprot id: A0A449BJV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

264636:EXC59 RS04845
gene id: 264636:EXC59_RS04845
uniprot id: A0A449BKI3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

264636:EXC59 RS01500
gene id: 264636:EXC59_RS01500
uniprot id: A0A449BIM8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

264636:EXC59 RS06605
gene id: 264636:EXC59_RS06605
uniprot id: A0A449BLF7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-allosteric.

264636:EXC59 RS03965
gene id: 264636:EXC59_RS03965
uniprot id: A0A449BK33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

264636:EXC59 RS04250
gene id: 264636:EXC59_RS04250
uniprot id: A0A449BK39
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

264636:EXC59 RS05545
gene id: 264636:EXC59_RS05545
uniprot id: A0A449BL02
names: Subcellular Location Annotation
messages: Membrane

264636:EXC59 RS03290
gene id: 264636:EXC59_RS03290
uniprot id: A0A449BJK4
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

264636:EXC59 RS04700
gene id: 264636:EXC59_RS04700
uniprot id: A0A449BKR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MrnC RNase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.

264636:EXC59 RS06735
gene id: 264636:EXC59_RS06735
uniprot id: A0A449BLI6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

264636:EXC59 RS01090
gene id: 264636:EXC59_RS01090
uniprot id: A0A449BIC5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

264636:EXC59 RS01855
gene id: 264636:EXC59_RS01855
uniprot id: A0A449BIR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Belongs to the 'phage' integrase family. XerD subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

264636:EXC59 RS04515
gene id: 264636:EXC59_RS04515
uniprot id: A0A449BKD6
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

264636:EXC59 RS04885
gene id: 264636:EXC59_RS04885
uniprot id: A0A449BKK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

264636:EXC59 RS04345
gene id: 264636:EXC59_RS04345
uniprot id: A0A449BK55
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

264636:EXC59 RS02750
gene id: 264636:EXC59_RS02750
uniprot id: A0A449BJC4
names: Similarity
messages: Belongs to the phosphohexose mutase family.

264636:EXC59 RS04755
gene id: 264636:EXC59_RS04755
uniprot id: A0A449BKG9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

264636:EXC59 RS06235
gene id: 264636:EXC59_RS06235
uniprot id: A0A449BL60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

264636:EXC59 RS05270
gene id: 264636:EXC59_RS05270
uniprot id: A0A449BKN4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

264636:EXC59 RS00180
gene id: 264636:EXC59_RS00180
uniprot id: A0A449BHU3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

264636:EXC59 RS04760
gene id: 264636:EXC59_RS04760
uniprot id: A0A449BKG1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

264636:EXC59 RS01400
gene id: 264636:EXC59_RS01400
uniprot id: A0A449BII0
names: Subcellular Location Annotation
messages: Membrane

264636:EXC59 RS00670
gene id: 264636:EXC59_RS00670
uniprot id: A0A449BIG0
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

264636:EXC59 RS04320
gene id: 264636:EXC59_RS04320
uniprot id: A0A449BK97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the auxin efflux carrier (TC 2.A.69) family.
messages: Cell membrane
messages: Membrane

264636:EXC59 RS02550
gene id: 264636:EXC59_RS02550
uniprot id: A0A449BJ77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

264636:EXC59 RS01780
gene id: 264636:EXC59_RS01780
uniprot id: A0A449BIQ6
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

264636:EXC59 RS00165
gene id: 264636:EXC59_RS00165
uniprot id: A0A449BHV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

264636:EXC59 RS05395
gene id: 264636:EXC59_RS05395
uniprot id: A0A449BKT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

264636:EXC59 RS03455
gene id: 264636:EXC59_RS03455
uniprot id: A0A449BK27
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

264636:EXC59 RS06720
gene id: 264636:EXC59_RS06720
uniprot id: A0A449BLH9
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

264636:EXC59 RS02960
gene id: 264636:EXC59_RS02960
uniprot id: A0A449BJE1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

264636:EXC59 RS01240
gene id: 264636:EXC59_RS01240
uniprot id: A0A449BII4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

264636:EXC59 RS01870
gene id: 264636:EXC59_RS01870
uniprot id: A0A449BIS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0154 family.
messages: Membrane

264636:EXC59 RS01815
gene id: 264636:EXC59_RS01815
uniprot id: A0A449BIX2
names: Similarity
messages: Belongs to the glutathione peroxidase family.

264636:EXC59 RS04055
gene id: 264636:EXC59_RS04055
uniprot id: A0A449BK23
names: Caution
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

264636:EXC59 RS01330
gene id: 264636:EXC59_RS01330
uniprot id: A0A449BIW2
names: Subcellular Location Annotation
messages: Membrane

264636:EXC59 RS04260
gene id: 264636:EXC59_RS04260
uniprot id: A0A449BK59
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

264636:EXC59 RS00275
gene id: 264636:EXC59_RS00275
uniprot id: A0A449BHY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

264636:EXC59 RS04160
gene id: 264636:EXC59_RS04160
uniprot id: A0A449BK68
names: Function
names: Similarity
messages: Belongs to the anhydro-N-acetylmuramic acid kinase family.
messages: Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.

264636:EXC59 RS06565
gene id: 264636:EXC59_RS06565
uniprot id: A0A449BLE9
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

264636:EXC59 RS03760
gene id: 264636:EXC59_RS03760
uniprot id: A0A449BJW5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

264636:EXC59 RS02875
gene id: 264636:EXC59_RS02875
uniprot id: A0A449BJD9
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

264636:EXC59 RS01830
gene id: 264636:EXC59_RS01830
uniprot id: A0A449BIR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

264636:EXC59 RS02950
gene id: 264636:EXC59_RS02950
uniprot id: A0A449BJS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

264636:EXC59 RS01215
gene id: 264636:EXC59_RS01215
uniprot id: A0A449BIF8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

264636:EXC59 RS03000
gene id: 264636:EXC59_RS03000
uniprot id: A0A449BJT7
names: Similarity
messages: Belongs to the Iojap/RsfS family.

264636:EXC59 RS00915
gene id: 264636:EXC59_RS00915
uniprot id: A0A449BIA1
names: Similarity
messages: Belongs to the NusB family.

264636:EXC59 RS01665
gene id: 264636:EXC59_RS01665
uniprot id: A0A449BIT9
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

264636:EXC59 RS04910
gene id: 264636:EXC59_RS04910
uniprot id: A0A449BKV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

264636:EXC59 RS01155
gene id: 264636:EXC59_RS01155
uniprot id: A0A449BIJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

264636:EXC59 RS02645
gene id: 264636:EXC59_RS02645
uniprot id: A0A449BJL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

264636:EXC59 RS04000
gene id: 264636:EXC59_RS04000
uniprot id: A0A449BK13
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

264636:EXC59 RS04425
gene id: 264636:EXC59_RS04425
uniprot id: A0A449BK71
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

264636:EXC59 RS00045
gene id: 264636:EXC59_RS00045
uniprot id: A0A449BHT0
names: Similarity
messages: Belongs to the peptidase U62 family.

264636:EXC59 RS03270
gene id: 264636:EXC59_RS03270
uniprot id: A0A449BJN9
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

264636:EXC59 RS01405
gene id: 264636:EXC59_RS01405
uniprot id: A0A449BIL1
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

264636:EXC59 RS04915
gene id: 264636:EXC59_RS04915
uniprot id: A0A449BKJ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

264636:EXC59 RS01315
gene id: 264636:EXC59_RS01315
uniprot id: A0A449BIG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

264636:EXC59 RS04860
gene id: 264636:EXC59_RS04860
uniprot id: A0A449BKU7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

264636:EXC59 RS02420
gene id: 264636:EXC59_RS02420
uniprot id: A0A449BJ38
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

264636:EXC59 RS04185
gene id: 264636:EXC59_RS04185
uniprot id: A0A449BK24
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

264636:EXC59 RS04115
gene id: 264636:EXC59_RS04115
uniprot id: A0A449BK11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

264636:EXC59 RS06615
gene id: 264636:EXC59_RS06615
uniprot id: A0A449BLF8
names: Similarity
messages: Belongs to the pyruvate kinase family.

264636:EXC59 RS05230
gene id: 264636:EXC59_RS05230
uniprot id: A0A449BKL2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
messages: Cytoplasm
messages: Homodimer.

264636:EXC59 RS06180
gene id: 264636:EXC59_RS06180
uniprot id: A0A449BL50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

264636:EXC59 RS00840
gene id: 264636:EXC59_RS00840
uniprot id: A0A449BI91
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

264636:EXC59 RS04785
gene id: 264636:EXC59_RS04785
uniprot id: A0A449BKN0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

264636:EXC59 RS05685
gene id: 264636:EXC59_RS05685
uniprot id: A0A449BKZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

264636:EXC59 RS06090
gene id: 264636:EXC59_RS06090
uniprot id: A0A449BL32
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

264636:EXC59 RS05805
gene id: 264636:EXC59_RS05805
uniprot id: A0A449BL18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

264636:EXC59 RS00250
gene id: 264636:EXC59_RS00250
uniprot id: A0A449BHX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

264636:EXC59 RS01635
gene id: 264636:EXC59_RS01635
uniprot id: A0A449BJ20
names: Similarity
messages: Belongs to the BMP lipoprotein family.

264636:EXC59 RS03220
gene id: 264636:EXC59_RS03220
uniprot id: A0A449BJM9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

264636:EXC59 RS03385
gene id: 264636:EXC59_RS03385
uniprot id: A0A449BJU7
names: Similarity
messages: Belongs to the Nudix hydrolase family.

264636:EXC59 RS01440
gene id: 264636:EXC59_RS01440
uniprot id: A0A449BIJ9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

264636:EXC59 RS02810
gene id: 264636:EXC59_RS02810
uniprot id: A0A449BJB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

264636:EXC59 RS05365
gene id: 264636:EXC59_RS05365
uniprot id: A0A449BKQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Cell membrane
messages: Membrane

264636:EXC59 RS00285
gene id: 264636:EXC59_RS00285
uniprot id: A0A449BHZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

264636:EXC59 RS05145
gene id: 264636:EXC59_RS05145
uniprot id: A0A449BKJ4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ApbE family.
messages: Cell inner membrane
messages: Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
messages: Magnesium. Can also use manganese.

264636:EXC59 RS05665
gene id: 264636:EXC59_RS05665
uniprot id: A0A449BKV7
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

264636:EXC59 RS06225
gene id: 264636:EXC59_RS06225
uniprot id: A0A449BL85
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

264636:EXC59 RS02070
gene id: 264636:EXC59_RS02070
uniprot id: A0A449BIW5
names: Subcellular Location Annotation
messages: Membrane

264636:EXC59 RS02595
gene id: 264636:EXC59_RS02595
uniprot id: A0A449BJ66
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

264636:EXC59 RS00050
gene id: 264636:EXC59_RS00050
uniprot id: A0A449BHS6
names: Similarity
messages: Belongs to the peptidase U62 family.

264636:EXC59 RS05680
gene id: 264636:EXC59_RS05680
uniprot id: A0A449BKV1
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
messages: Homohexamer.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

264636:EXC59 RS02280
gene id: 264636:EXC59_RS02280
uniprot id: A0A449BJ09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

264636:EXC59 RS06210
gene id: 264636:EXC59_RS06210
uniprot id: A0A449BL51
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

264636:EXC59 RS04545
gene id: 264636:EXC59_RS04545
uniprot id: A0A449BKA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

264636:EXC59 RS05320
gene id: 264636:EXC59_RS05320
uniprot id: A0A449BKP9
names: Subcellular Location Annotation
messages: Membrane

264636:EXC59 RS05445
gene id: 264636:EXC59_RS05445
uniprot id: A0A449BKU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

264636:EXC59 RS03295
gene id: 264636:EXC59_RS03295
uniprot id: A0A449BJK3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

264636:EXC59 RS03195
gene id: 264636:EXC59_RS03195
uniprot id: A0A449BJI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

264636:EXC59 RS03450
gene id: 264636:EXC59_RS03450
uniprot id: A0A449BJN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

264636:EXC59 RS06105
gene id: 264636:EXC59_RS06105
uniprot id: A0A449BL31
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

264636:EXC59 RS00650
gene id: 264636:EXC59_RS00650
uniprot id: A0A449BI42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

264636:EXC59 RS00140
gene id: 264636:EXC59_RS00140
uniprot id: A0A449BHY4
names: Subcellular Location Annotation
messages: Membrane

264636:EXC59 RS03425
gene id: 264636:EXC59_RS03425
uniprot id: A0A449BJM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

264636:EXC59 RS04525
gene id: 264636:EXC59_RS04525
uniprot id: A0A449BKD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

264636:EXC59 RS05465
gene id: 264636:EXC59_RS05465
uniprot id: A0A449BKR3
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

264636:EXC59 RS03020
gene id: 264636:EXC59_RS03020
uniprot id: A0A449BJE7
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

264636:EXC59 RS00105
gene id: 264636:EXC59_RS00105
uniprot id: A0A449BHT5
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.

264636:EXC59 RS00455
gene id: 264636:EXC59_RS00455
uniprot id: A0A449BI18
names: Similarity
messages: Belongs to the glutathione peroxidase family.

264636:EXC59 RS04265
gene id: 264636:EXC59_RS04265
uniprot id: A0A449BK67
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

264636:EXC59 RS01025
gene id: 264636:EXC59_RS01025
uniprot id: A0A449BID4
names: Subcellular Location Annotation
messages: Membrane

264636:EXC59 RS03380
gene id: 264636:EXC59_RS03380
uniprot id: A0A449BJN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

264636:EXC59 RS05215
gene id: 264636:EXC59_RS05215
uniprot id: A0A449BKL9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

264636:EXC59 RS01630
gene id: 264636:EXC59_RS01630
uniprot id: A0A449BIM9
names: Subcellular Location Annotation
messages: Membrane

264636:EXC59 RS05775
gene id: 264636:EXC59_RS05775
uniprot id: A0A449BKX4
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

264636:EXC59 RS06265
gene id: 264636:EXC59_RS06265
uniprot id: A0A449BL93
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

264636:EXC59 RS05440
gene id: 264636:EXC59_RS05440
uniprot id: A0A449BKY5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

264636:EXC59 RS03445
gene id: 264636:EXC59_RS03445
uniprot id: A0A449BJN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

264636:EXC59 RS05740
gene id: 264636:EXC59_RS05740
uniprot id: A0A449BL09
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

264636:EXC59 RS01980
gene id: 264636:EXC59_RS01980
uniprot id: A0A449BIV0
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.

264636:EXC59 RS02050
gene id: 264636:EXC59_RS02050
uniprot id: A0A449BIZ2
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.

264636:EXC59 RS06010
gene id: 264636:EXC59_RS06010
uniprot id: A0A449BL89
names: Similarity
messages: Belongs to the peptidase C56 family.

264636:EXC59 RS00100
gene id: 264636:EXC59_RS00100
uniprot id: A0A449BHU1
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.

264636:EXC59 RS06940
gene id: 264636:EXC59_RS06940
uniprot id: A0A449BLN3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

264636:EXC59 RS01485
gene id: 264636:EXC59_RS01485
uniprot id: A0A449BIZ0
names: Similarity
messages: Belongs to the lipase/esterase LIP3/BchO family.

264636:EXC59 RS06120
gene id: 264636:EXC59_RS06120
uniprot id: A0A449BL72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

264636:EXC59 RS01480
gene id: 264636:EXC59_RS01480
uniprot id: A0A449BIJ6
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

264636:EXC59 RS01185
gene id: 264636:EXC59_RS01185
uniprot id: A0A449BIF3
names: Subcellular Location Annotation
messages: Membrane

264636:EXC59 RS05525
gene id: 264636:EXC59_RS05525
uniprot id: A0A449BKU2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

264636:EXC59 RS04570
gene id: 264636:EXC59_RS04570
uniprot id: A0A449BKA2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

264636:EXC59 RS03285
gene id: 264636:EXC59_RS03285
uniprot id: A0A449BJS7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CoaE family.
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

264636:EXC59 RS03070
gene id: 264636:EXC59_RS03070
uniprot id: A0A449BJF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

264636:EXC59 RS01990
gene id: 264636:EXC59_RS01990
uniprot id: A0A449BJ90
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

264636:EXC59 RS06850
gene id: 264636:EXC59_RS06850
uniprot id: A0A449BLK2
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

264636:EXC59 RS04960
gene id: 264636:EXC59_RS04960
uniprot id: A0A449BKX0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

264636:EXC59 RS05535
gene id: 264636:EXC59_RS05535
uniprot id: A0A449BKS2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

264636:EXC59 RS00075
gene id: 264636:EXC59_RS00075
uniprot id: A0A449BHU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

264636:EXC59 RS05275
gene id: 264636:EXC59_RS05275
uniprot id: A0A449BKR7
names: Function
names: Similarity
messages: Belongs to the SpoVG family.
messages: Could be involved in septation.

264636:EXC59 RS01250
gene id: 264636:EXC59_RS01250
uniprot id: A0A449BII3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

264636:EXC59 RS05325
gene id: 264636:EXC59_RS05325
uniprot id: A0A449BKS7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

264636:EXC59 RS03150
gene id: 264636:EXC59_RS03150
uniprot id: A0A449BJW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

264636:EXC59 RS05255
gene id: 264636:EXC59_RS05255
uniprot id: A0A449BKL4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

264636:EXC59 RS06610
gene id: 264636:EXC59_RS06610
uniprot id: A0A449BLF4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

264636:EXC59 RS04890
gene id: 264636:EXC59_RS04890
uniprot id: A0A449BKQ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

264636:EXC59 RS04895
gene id: 264636:EXC59_RS04895
uniprot id: A0A449BKJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

264636:EXC59 RS00950
gene id: 264636:EXC59_RS00950
uniprot id: A0A449BIE1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

264636:EXC59 RS00255
gene id: 264636:EXC59_RS00255
uniprot id: A0A449BHW7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

264636:EXC59 RS02965
gene id: 264636:EXC59_RS02965
uniprot id: A0A449BJH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

264636:EXC59 RS04355
gene id: 264636:EXC59_RS04355
uniprot id: A0A449BKJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

264636:EXC59 RS04120
gene id: 264636:EXC59_RS04120
uniprot id: A0A449BK42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

264636:EXC59 RS01735
gene id: 264636:EXC59_RS01735
uniprot id: A0A449BIS6
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

264636:EXC59 RS03090
gene id: 264636:EXC59_RS03090
uniprot id: A0A449BJG7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

264636:EXC59 RS02605
gene id: 264636:EXC59_RS02605
uniprot id: A0A449BJ71
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

264636:EXC59 RS05645
gene id: 264636:EXC59_RS05645
uniprot id: A0A449BKY3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

264636:EXC59 RS05350
gene id: 264636:EXC59_RS05350
uniprot id: A0A449BKN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

264636:EXC59 RS04955
gene id: 264636:EXC59_RS04955
uniprot id: A0A449BKI5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

264636:EXC59 RS04065
gene id: 264636:EXC59_RS04065
uniprot id: A0A449BK00
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.
messages: Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
messages: Homodimer.
messages: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.

264636:EXC59 RS02555
gene id: 264636:EXC59_RS02555
uniprot id: A0A449BJ60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

264636:EXC59 RS01510
gene id: 264636:EXC59_RS01510
uniprot id: A0A449BIN0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

264636:EXC59 RS03470
gene id: 264636:EXC59_RS03470
uniprot id: A0A449BJT1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

264636:EXC59 RS02360
gene id: 264636:EXC59_RS02360
uniprot id: A0A449BJ16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

264636:EXC59 RS02105
gene id: 264636:EXC59_RS02105
uniprot id: A0A449BIW8
names: Similarity
messages: Belongs to the glycosyl hydrolase 20 family.

264636:EXC59 RS06425
gene id: 264636:EXC59_RS06425
uniprot id: A0A449BLB4
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

264636:EXC59 RS06035
gene id: 264636:EXC59_RS06035
uniprot id: A0A449BL24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

264636:EXC59 RS04970
gene id: 264636:EXC59_RS04970
uniprot id: A0A449BKJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

264636:EXC59 RS04235
gene id: 264636:EXC59_RS04235
uniprot id: A0A449BKB0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

264636:EXC59 RS03400
gene id: 264636:EXC59_RS03400
uniprot id: A0A449BJM2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

264636:EXC59 RS02755
gene id: 264636:EXC59_RS02755
uniprot id: A0A449BJ99
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

264636:EXC59 RS04965
gene id: 264636:EXC59_RS04965
uniprot id: A0A449BKK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

264636:EXC59 RS05095
gene id: 264636:EXC59_RS05095
uniprot id: A0A449BKJ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

264636:EXC59 RS01645
gene id: 264636:EXC59_RS01645
uniprot id: A0A449BIN6
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

264636:EXC59 RS06125
gene id: 264636:EXC59_RS06125
uniprot id: A0A449BL33
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

264636:EXC59 RS05245
gene id: 264636:EXC59_RS05245
uniprot id: A0A449BKQ8
names: Subcellular Location Annotation
messages: Membrane

264636:EXC59 RS06270
gene id: 264636:EXC59_RS06270
uniprot id: A0A449BLA3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

264636:EXC59 RS02415
gene id: 264636:EXC59_RS02415
uniprot id: A0A449BJ96
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

264636:EXC59 RS00080
gene id: 264636:EXC59_RS00080
uniprot id: A0A449BHS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane

264636:EXC59 RS04275
gene id: 264636:EXC59_RS04275
uniprot id: A0A449BK40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. PolC subfamily.
messages: Cytoplasm
messages: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

264636:EXC59 RS05455
gene id: 264636:EXC59_RS05455
uniprot id: A0A449BKP5
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

264636:EXC59 RS02630
gene id: 264636:EXC59_RS02630
uniprot id: A0A449BJ78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

264636:EXC59 RS02765
gene id: 264636:EXC59_RS02765
uniprot id: A0A449BJA5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

264636:EXC59 RS00035
gene id: 264636:EXC59_RS00035
uniprot id: A0A449BHW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Membrane

264636:EXC59 RS02665
gene id: 264636:EXC59_RS02665
uniprot id: A0A449BJ79
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecU family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation.

264636:EXC59 RS02165
gene id: 264636:EXC59_RS02165
uniprot id: A0A449BJ48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

264636:EXC59 RS06740
gene id: 264636:EXC59_RS06740
uniprot id: A0A449BLJ4
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

264636:EXC59 RS01265
gene id: 264636:EXC59_RS01265
uniprot id: A0A449BIF6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

264636:EXC59 RS02110
gene id: 264636:EXC59_RS02110
uniprot id: A0A449BIZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

264636:EXC59 RS05555
gene id: 264636:EXC59_RS05555
uniprot id: A0A449BKS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

264636:EXC59 RS02970
gene id: 264636:EXC59_RS02970
uniprot id: A0A449BJE0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

264636:EXC59 RS06795
gene id: 264636:EXC59_RS06795
uniprot id: A0A449BLI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

264636:EXC59 RS00930
gene id: 264636:EXC59_RS00930
uniprot id: A0A449BIB1
names: Similarity
messages: Belongs to the TlyA family.

264636:EXC59 RS03590
gene id: 264636:EXC59_RS03590
uniprot id: A0A449BJR3
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

264636:EXC59 RS05760
gene id: 264636:EXC59_RS05760
uniprot id: A0A449BKW7
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

264636:EXC59 RS04705
gene id: 264636:EXC59_RS04705
uniprot id: A0A449BKF9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

264636:EXC59 RS04900
gene id: 264636:EXC59_RS04900
uniprot id: A0A449BKG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

264636:EXC59 RS01015
gene id: 264636:EXC59_RS01015
uniprot id: A0A449BIB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

264636:EXC59 RS06170
gene id: 264636:EXC59_RS06170
uniprot id: A0A449BL80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpA RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpB.

264636:EXC59 RS04735
gene id: 264636:EXC59_RS04735
uniprot id: A0A449BKG3
names: Similarity
messages: Belongs to the SecB family.

264636:EXC59 RS01600
gene id: 264636:EXC59_RS01600
uniprot id: A0A449BIP7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

264636:EXC59 RS00460
gene id: 264636:EXC59_RS00460
uniprot id: A0A449BI10
names: Subcellular Location Annotation
messages: Membrane

264636:EXC59 RS06575
gene id: 264636:EXC59_RS06575
uniprot id: A0A449BLE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

264636:EXC59 RS02715
gene id: 264636:EXC59_RS02715
uniprot id: A0A449BJ92
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

264636:EXC59 RS04605
gene id: 264636:EXC59_RS04605
uniprot id: A0A449BKE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

264636:EXC59 RS00835
gene id: 264636:EXC59_RS00835
uniprot id: A0A449BI76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

264636:EXC59 RS06305
gene id: 264636:EXC59_RS06305
uniprot id: A0A449BL96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane