262543:EXIG RS04970
gene id: 262543:EXIG_RS04970
uniprot id: B1YLS4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

262543:EXIG RS00610
gene id: 262543:EXIG_RS00610
uniprot id: B1YGT8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

262543:EXIG RS09945
gene id: 262543:EXIG_RS09945
uniprot id: B1YIR5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

262543:EXIG RS12390
gene id: 262543:EXIG_RS12390
uniprot id: B1YLH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

262543:EXIG RS11850
gene id: 262543:EXIG_RS11850
uniprot id: B1YKX3
names: Similarity
messages: Belongs to the HepT RNase toxin family.

262543:EXIG RS01960
gene id: 262543:EXIG_RS01960
uniprot id: B1YIE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS14385
gene id: 262543:EXIG_RS14385
uniprot id: B1YF44
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS10485
gene id: 262543:EXIG_RS10485
uniprot id: B1YJC0
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MecA family.
messages: Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.
messages: Homodimer.
messages: The N-terminal domain probably binds unfolded/aggregated proteins; the C-terminal domain interacts with ClpC.

262543:EXIG RS04770
gene id: 262543:EXIG_RS04770
uniprot id: B1YLD5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

262543:EXIG RS10685
gene id: 262543:EXIG_RS10685
uniprot id: B1YJG2
names: Similarity
messages: Belongs to the RecJ family.

262543:EXIG RS04670
gene id: 262543:EXIG_RS04670
uniprot id: B1YLB5
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

262543:EXIG RS11075
gene id: 262543:EXIG_RS11075
uniprot id: B1YJY3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

262543:EXIG RS02205
gene id: 262543:EXIG_RS02205
uniprot id: B1YIJ6
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

262543:EXIG RS10115
gene id: 262543:EXIG_RS10115
uniprot id: B1YIV0
names: Similarity
messages: Belongs to the peptidase S16 family.

262543:EXIG RS10790
gene id: 262543:EXIG_RS10790
uniprot id: B1YJS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

262543:EXIG RS12070
gene id: 262543:EXIG_RS12070
uniprot id: B1YL17
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

262543:EXIG RS08690
gene id: 262543:EXIG_RS08690
uniprot id: B1YHH0
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

262543:EXIG RS10660
gene id: 262543:EXIG_RS10660
uniprot id: B1YJF7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
messages: Cytoplasm
messages: Homodimer.

262543:EXIG RS03325
gene id: 262543:EXIG_RS03325
uniprot id: B1YK17
names: Similarity
messages: Belongs to the CvfB family.

262543:EXIG RS11275
gene id: 262543:EXIG_RS11275
uniprot id: B1YKA8
names: Similarity
messages: Belongs to the citrate synthase family.

262543:EXIG RS09695
gene id: 262543:EXIG_RS09695
uniprot id: B1YIL5
names: Similarity
messages: Belongs to the DprA/Smf family.

262543:EXIG RS00400
gene id: 262543:EXIG_RS00400
uniprot id: B1YGQ8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

262543:EXIG RS08075
gene id: 262543:EXIG_RS08075
uniprot id: B1YGL6
names: Similarity
messages: Belongs to the asp23 family.

262543:EXIG RS02515
gene id: 262543:EXIG_RS02515
uniprot id: B1YJ07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

262543:EXIG RS00715
gene id: 262543:EXIG_RS00715
uniprot id: B1YGV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

262543:EXIG RS01745
gene id: 262543:EXIG_RS01745
uniprot id: B1YI03
names: Similarity
messages: Belongs to the Nudix hydrolase family.

262543:EXIG RS10010
gene id: 262543:EXIG_RS10010
uniprot id: B1YIS8
names: Subcellular Location Annotation
messages: Cytoplasm

262543:EXIG RS05410
gene id: 262543:EXIG_RS05410
uniprot id: B1YMB0
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS02920
gene id: 262543:EXIG_RS02920
uniprot id: B1YJI5
names: Similarity
messages: Belongs to the OsmC/Ohr family.

262543:EXIG RS02565
gene id: 262543:EXIG_RS02565
uniprot id: B1YJ17
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

262543:EXIG RS07330
gene id: 262543:EXIG_RS07330
uniprot id: B1YFV1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase D family. Cardiolipin synthase subfamily.
messages: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
messages: Cell membrane
messages: Membrane

262543:EXIG RS01955
gene id: 262543:EXIG_RS01955
uniprot id: B1YIE6
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS05555
gene id: 262543:EXIG_RS05555
uniprot id: B1YMD9
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS14670
gene id: 262543:EXIG_RS14670
uniprot id: B1YFK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Membrane

262543:EXIG RS03540
gene id: 262543:EXIG_RS03540
uniprot id: B1YK59
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

262543:EXIG RS12430
gene id: 262543:EXIG_RS12430
uniprot id: B1YLI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.
messages: Secreted

262543:EXIG RS01315
gene id: 262543:EXIG_RS01315
uniprot id: B1YHG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

262543:EXIG RS03485
gene id: 262543:EXIG_RS03485
uniprot id: B1YK48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

262543:EXIG RS02985
gene id: 262543:EXIG_RS02985
uniprot id: B1YJJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

262543:EXIG RS15090
gene id: 262543:EXIG_RS15090
uniprot id: B1YG28
names: Similarity
messages: Belongs to the UPF0751 family.

262543:EXIG RS09520
gene id: 262543:EXIG_RS09520
uniprot id: B1YI79
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

262543:EXIG RS13705
gene id: 262543:EXIG_RS13705
uniprot id: B1YEH8
names: Caution
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

262543:EXIG RS02015
gene id: 262543:EXIG_RS02015
uniprot id: B1YIF8
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

262543:EXIG RS13980
gene id: 262543:EXIG_RS13980
uniprot id: B1YEN5
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS12250
gene id: 262543:EXIG_RS12250
uniprot id: B1YLE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

262543:EXIG RS13865
gene id: 262543:EXIG_RS13865
uniprot id: B1YEL1
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

262543:EXIG RS01605
gene id: 262543:EXIG_RS01605
uniprot id: B1YHX6
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS15195
gene id: 262543:EXIG_RS15195
uniprot id: B1YG49
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

262543:EXIG RS11795
gene id: 262543:EXIG_RS11795
uniprot id: B1YKW2
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 2 family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

262543:EXIG RS15250
gene id: 262543:EXIG_RS15250
uniprot id: B1YG60
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

262543:EXIG RS15500
gene id: 262543:EXIG_RS15500
uniprot id: B1YGB1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

262543:EXIG RS01210
gene id: 262543:EXIG_RS01210
uniprot id: B1YHE7
names: Cofactor
names: Similarity
messages: Belongs to the nitroreductase family.
messages: Binds 1 FMN per subunit.

262543:EXIG RS01905
gene id: 262543:EXIG_RS01905
uniprot id: B1YID6
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS07010
gene id: 262543:EXIG_RS07010
uniprot id: B1YFE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS13625
gene id: 262543:EXIG_RS13625
uniprot id: B1YEG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

262543:EXIG RS02155
gene id: 262543:EXIG_RS02155
uniprot id: B1YII6
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

262543:EXIG RS08665
gene id: 262543:EXIG_RS08665
uniprot id: B1YH77
names: Subcellular Location Annotation
messages: Cytoplasm

262543:EXIG RS02280
gene id: 262543:EXIG_RS02280
uniprot id: B1YIL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS01530
gene id: 262543:EXIG_RS01530
uniprot id: B1YHW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

262543:EXIG RS05715
gene id: 262543:EXIG_RS05715
uniprot id: B1YMH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

262543:EXIG RS11105
gene id: 262543:EXIG_RS11105
uniprot id: B1YJY9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family. RnhC subfamily.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

262543:EXIG RS11885
gene id: 262543:EXIG_RS11885
uniprot id: B1YKY0
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

262543:EXIG RS13780
gene id: 262543:EXIG_RS13780
uniprot id: B1YEJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

262543:EXIG RS02815
gene id: 262543:EXIG_RS02815
uniprot id: B1YJG6
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS04445
gene id: 262543:EXIG_RS04445
uniprot id: B1YL72
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

262543:EXIG RS11080
gene id: 262543:EXIG_RS11080
uniprot id: B1YJY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0719 family.
messages: Membrane

262543:EXIG RS08975
gene id: 262543:EXIG_RS08975
uniprot id: B1YHM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0053 family.
messages: Membrane

262543:EXIG RS12005
gene id: 262543:EXIG_RS12005
uniprot id: B1YL04
names: Cofactor
messages: Binds 1 FAD per subunit.

262543:EXIG RS03900
gene id: 262543:EXIG_RS03900
uniprot id: B1YKL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

262543:EXIG RS04035
gene id: 262543:EXIG_RS04035
uniprot id: B1YKP0
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

262543:EXIG RS10550
gene id: 262543:EXIG_RS10550
uniprot id: B1YJD4
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

262543:EXIG RS10250
gene id: 262543:EXIG_RS10250
uniprot id: B1YJ72
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

262543:EXIG RS04930
gene id: 262543:EXIG_RS04930
uniprot id: B1YLR6
names: Function
names: Similarity
messages: Belongs to the BCKDHA family.
messages: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

262543:EXIG RS09640
gene id: 262543:EXIG_RS09640
uniprot id: B1YIA3
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Membrane

262543:EXIG RS09405
gene id: 262543:EXIG_RS09405
uniprot id: B1YI56
names: Similarity
messages: Belongs to the peptidase M16 family.

262543:EXIG RS12775
gene id: 262543:EXIG_RS12775
uniprot id: B1YM01
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

262543:EXIG RS09760
gene id: 262543:EXIG_RS09760
uniprot id: B1YIM8
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

262543:EXIG RS01385
gene id: 262543:EXIG_RS01385
uniprot id: B1YHT1
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Converts GTP to 7,8-dihydroneopterin triphosphate.

262543:EXIG RS15125
gene id: 262543:EXIG_RS15125
uniprot id: B1YG35
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DEAD box helicase family. DbpA subfamily.
messages: Contains an N-terminal domain that binds non-specifically to RNA and a C-terminal domain that binds specifically and tightly to hairpin 92 of 23S rRNA.
messages: Cytoplasm
messages: DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes.

262543:EXIG RS00650
gene id: 262543:EXIG_RS00650
uniprot id: B1YGU6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

262543:EXIG RS05640
gene id: 262543:EXIG_RS05640
uniprot id: B1YMF6
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS05060
gene id: 262543:EXIG_RS05060
uniprot id: B1YLU2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPase class C family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm

262543:EXIG RS05265
gene id: 262543:EXIG_RS05265
uniprot id: B1YM81
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

262543:EXIG RS11015
gene id: 262543:EXIG_RS11015
uniprot id: B1YJX1
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

262543:EXIG RS14060
gene id: 262543:EXIG_RS14060
uniprot id: B1YEQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

262543:EXIG RS09685
gene id: 262543:EXIG_RS09685
uniprot id: B1YIB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

262543:EXIG RS09270
gene id: 262543:EXIG_RS09270
uniprot id: B1YI30
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

262543:EXIG RS12290
gene id: 262543:EXIG_RS12290
uniprot id: B1YLF7
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.
messages: Homohexamer.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

262543:EXIG RS09215
gene id: 262543:EXIG_RS09215
uniprot id: B1YI19
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm

262543:EXIG RS14325
gene id: 262543:EXIG_RS14325
uniprot id: B1YF32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

262543:EXIG RS03670
gene id: 262543:EXIG_RS03670
uniprot id: B1YK68
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

262543:EXIG RS09545
gene id: 262543:EXIG_RS09545
uniprot id: B1YI84
names: Function
names: Similarity
messages: Belongs to the GTP-binding SRP family.
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

262543:EXIG RS05255
gene id: 262543:EXIG_RS05255
uniprot id: B1YM79
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

262543:EXIG RS04605
gene id: 262543:EXIG_RS04605
uniprot id: B1YLA4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

262543:EXIG RS14860
gene id: 262543:EXIG_RS14860
uniprot id: B1YFN9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

262543:EXIG RS04475
gene id: 262543:EXIG_RS04475
uniprot id: B1YL78
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.

262543:EXIG RS04695
gene id: 262543:EXIG_RS04695
uniprot id: B1YLC0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

262543:EXIG RS08970
gene id: 262543:EXIG_RS08970
uniprot id: B1YHM3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

262543:EXIG RS04675
gene id: 262543:EXIG_RS04675
uniprot id: B1YLB6
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

262543:EXIG RS10000
gene id: 262543:EXIG_RS10000
uniprot id: B1YIS6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

262543:EXIG RS14330
gene id: 262543:EXIG_RS14330
uniprot id: B1YF33
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS00345
gene id: 262543:EXIG_RS00345
uniprot id: B1YGP9
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS14800
gene id: 262543:EXIG_RS14800
uniprot id: B1YFM7
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

262543:EXIG RS07735
gene id: 262543:EXIG_RS07735
uniprot id: B1YGE8
names: Similarity
messages: Belongs to the YciI family.

262543:EXIG RS10285
gene id: 262543:EXIG_RS10285
uniprot id: B1YJ80
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

262543:EXIG RS13540
gene id: 262543:EXIG_RS13540
uniprot id: B1YMQ3
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS02130
gene id: 262543:EXIG_RS02130
uniprot id: B1YII1
names: Similarity
messages: Belongs to the aldose epimerase family.

262543:EXIG RS08780
gene id: 262543:EXIG_RS08780
uniprot id: B1YHI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS02955
gene id: 262543:EXIG_RS02955
uniprot id: B1YJJ3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

262543:EXIG RS04735
gene id: 262543:EXIG_RS04735
uniprot id: B1YLC8
names: Similarity
messages: Belongs to the GSP E family.

262543:EXIG RS03205
gene id: 262543:EXIG_RS03205
uniprot id: B1YJP2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

262543:EXIG RS09655
gene id: 262543:EXIG_RS09655
uniprot id: B1YIA6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

262543:EXIG RS10080
gene id: 262543:EXIG_RS10080
uniprot id: B1YIU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsL family.
messages: Cell membrane
messages: Essential cell division protein.
messages: Membrane

262543:EXIG RS05585
gene id: 262543:EXIG_RS05585
uniprot id: B1YME5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. EmrB family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS15475
gene id: 262543:EXIG_RS15475
uniprot id: B1YGA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Specifically methylates the N7 position of guanine in position 535 of 16S rRNA.

262543:EXIG RS10100
gene id: 262543:EXIG_RS10100
uniprot id: B1YIU6
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

262543:EXIG RS10715
gene id: 262543:EXIG_RS10715
uniprot id: B1YJR2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

262543:EXIG RS10515
gene id: 262543:EXIG_RS10515
uniprot id: B1YJC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS09990
gene id: 262543:EXIG_RS09990
uniprot id: B1YIS4
names: Function
names: Similarity
names: Subunit
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Homodimer and homohexamer; in equilibrium.
messages: Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.

262543:EXIG RS05655
gene id: 262543:EXIG_RS05655
uniprot id: B1YMF9
names: Subcellular Location Annotation
messages: Cell membrane

262543:EXIG RS11040
gene id: 262543:EXIG_RS11040
uniprot id: B1YJX6
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

262543:EXIG RS03965
gene id: 262543:EXIG_RS03965
uniprot id: B1YKM6
names: Similarity
messages: Belongs to the truncated hemoglobin family. Group II subfamily.

262543:EXIG RS11565
gene id: 262543:EXIG_RS11565
uniprot id: B1YKG6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

262543:EXIG RS13600
gene id: 262543:EXIG_RS13600
uniprot id: B1YMR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

262543:EXIG RS00070
gene id: 262543:EXIG_RS00070
uniprot id: B1YGC2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

262543:EXIG RS03050
gene id: 262543:EXIG_RS03050
uniprot id: B1YJL1
names: Similarity
messages: Belongs to the flavin oxidoreductase frp family.

262543:EXIG RS08010
gene id: 262543:EXIG_RS08010
uniprot id: B1YGK3
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS12285
gene id: 262543:EXIG_RS12285
uniprot id: B1YLF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

262543:EXIG RS03405
gene id: 262543:EXIG_RS03405
uniprot id: B1YK32
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS07530
gene id: 262543:EXIG_RS07530
uniprot id: B1YFY4
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

262543:EXIG RS09230
gene id: 262543:EXIG_RS09230
uniprot id: B1YI22
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

262543:EXIG RS15765
gene id: 262543:EXIG_RS15765
uniprot id: B1YIU7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

262543:EXIG RS11360
gene id: 262543:EXIG_RS11360
uniprot id: B1YKC5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

262543:EXIG RS05505
gene id: 262543:EXIG_RS05505
uniprot id: B1YMC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

262543:EXIG RS04685
gene id: 262543:EXIG_RS04685
uniprot id: B1YLB8
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

262543:EXIG RS04525
gene id: 262543:EXIG_RS04525
uniprot id: B1YL88
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

262543:EXIG RS05355
gene id: 262543:EXIG_RS05355
uniprot id: B1YM99
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

262543:EXIG RS11915
gene id: 262543:EXIG_RS11915
uniprot id: B1YKY5
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

262543:EXIG RS09725
gene id: 262543:EXIG_RS09725
uniprot id: B1YIM1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.
messages: Cytoplasm
messages: Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity.

262543:EXIG RS10865
gene id: 262543:EXIG_RS10865
uniprot id: B1YJU2
names: Function
messages: Required for transformation and DNA binding.

262543:EXIG RS13630
gene id: 262543:EXIG_RS13630
uniprot id: B1YEG3
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS04275
gene id: 262543:EXIG_RS04275
uniprot id: B1YKT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

262543:EXIG RS13710
gene id: 262543:EXIG_RS13710
uniprot id: B1YEH9
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

262543:EXIG RS13415
gene id: 262543:EXIG_RS13415
uniprot id: B1YMM8
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

262543:EXIG RS13700
gene id: 262543:EXIG_RS13700
uniprot id: B1YEH7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.

262543:EXIG RS14045
gene id: 262543:EXIG_RS14045
uniprot id: B1YEP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

262543:EXIG RS12210
gene id: 262543:EXIG_RS12210
uniprot id: B1YLE2
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

262543:EXIG RS07210
gene id: 262543:EXIG_RS07210
uniprot id: B1YFH8
names: Subcellular Location Annotation
messages: Cell membrane

262543:EXIG RS03200
gene id: 262543:EXIG_RS03200
uniprot id: B1YJP1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
messages: Homohexamer; trimer of homodimers.

262543:EXIG RS02745
gene id: 262543:EXIG_RS02745
uniprot id: B1YJ53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

262543:EXIG RS11650
gene id: 262543:EXIG_RS11650
uniprot id: B1YKI2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

262543:EXIG RS09345
gene id: 262543:EXIG_RS09345
uniprot id: B1YI44
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

262543:EXIG RS12040
gene id: 262543:EXIG_RS12040
uniprot id: B1YL11
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

262543:EXIG RS06375
gene id: 262543:EXIG_RS06375
uniprot id: B1YET4
names: Similarity
messages: Belongs to the manganese catalase family.

262543:EXIG RS00570
gene id: 262543:EXIG_RS00570
uniprot id: B1YGT0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MrnC RNase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors.

262543:EXIG RS05760
gene id: 262543:EXIG_RS05760
uniprot id: B1YE64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

262543:EXIG RS02100
gene id: 262543:EXIG_RS02100
uniprot id: B1YIH5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS12625
gene id: 262543:EXIG_RS12625
uniprot id: B1YLM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

262543:EXIG RS09025
gene id: 262543:EXIG_RS09025
uniprot id: B1YHN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: In the C-terminal section; belongs to the OsmX family.
messages: In the N-terminal section; belongs to the binding-protein-dependent transport system permease family.
messages: Membrane

262543:EXIG RS02385
gene id: 262543:EXIG_RS02385
uniprot id: B1YIY4
names: Function
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

262543:EXIG RS08455
gene id: 262543:EXIG_RS08455
uniprot id: B1YH37
names: Similarity
messages: Belongs to the YciI family.

262543:EXIG RS05925
gene id: 262543:EXIG_RS05925
uniprot id: B1YE97
names: Cofactor
names: Similarity
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.

262543:EXIG RS10530
gene id: 262543:EXIG_RS10530
uniprot id: B1YJD0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

262543:EXIG RS01850
gene id: 262543:EXIG_RS01850
uniprot id: B1YIC5
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

262543:EXIG RS03935
gene id: 262543:EXIG_RS03935
uniprot id: B1YKL9
names: Function
names: Similarity
messages: Belongs to the methylglyoxal synthase family.
messages: Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.

262543:EXIG RS00230
gene id: 262543:EXIG_RS00230
uniprot id: B1YGD2
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

262543:EXIG RS09720
gene id: 262543:EXIG_RS09720
uniprot id: B1YIM0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

262543:EXIG RS02715
gene id: 262543:EXIG_RS02715
uniprot id: B1YJ47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: In the C-terminal section; belongs to the OsmX family.
messages: In the N-terminal section; belongs to the binding-protein-dependent transport system permease family.
messages: Membrane

262543:EXIG RS15380
gene id: 262543:EXIG_RS15380
uniprot id: B1YG87
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS04110
gene id: 262543:EXIG_RS04110
uniprot id: B1YKQ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

262543:EXIG RS08955
gene id: 262543:EXIG_RS08955
uniprot id: B1YHM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

262543:EXIG RS04260
gene id: 262543:EXIG_RS04260
uniprot id: B1YKT4
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

262543:EXIG RS02765
gene id: 262543:EXIG_RS02765
uniprot id: B1YJ57
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

262543:EXIG RS12320
gene id: 262543:EXIG_RS12320
uniprot id: B1YLG3
names: Similarity
messages: Belongs to the peptidase S41A family.

262543:EXIG RS09705
gene id: 262543:EXIG_RS09705
uniprot id: B1YIL7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

262543:EXIG RS04555
gene id: 262543:EXIG_RS04555
uniprot id: B1YL94
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

262543:EXIG RS04680
gene id: 262543:EXIG_RS04680
uniprot id: B1YLB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

262543:EXIG RS13095
gene id: 262543:EXIG_RS13095
uniprot id: B1YM64
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS04870
gene id: 262543:EXIG_RS04870
uniprot id: B1YLQ4
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

262543:EXIG RS12160
gene id: 262543:EXIG_RS12160
uniprot id: B1YL35
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

262543:EXIG RS04595
gene id: 262543:EXIG_RS04595
uniprot id: B1YLA2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

262543:EXIG RS09550
gene id: 262543:EXIG_RS09550
uniprot id: B1YI85
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

262543:EXIG RS05810
gene id: 262543:EXIG_RS05810
uniprot id: B1YE74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0291 family.
messages: Cytoplasm

262543:EXIG RS10020
gene id: 262543:EXIG_RS10020
uniprot id: B1YIT0
names: Similarity
messages: Belongs to the YggT family.

262543:EXIG RS04060
gene id: 262543:EXIG_RS04060
uniprot id: B1YKP5
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

262543:EXIG RS05930
gene id: 262543:EXIG_RS05930
uniprot id: B1YE98
names: Function
names: Similarity
messages: Belongs to the transposase IS30 family.
messages: Required for the transposition of the insertion element.

262543:EXIG RS08420
gene id: 262543:EXIG_RS08420
uniprot id: B1YH30
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

262543:EXIG RS00770
gene id: 262543:EXIG_RS00770
uniprot id: B1YGX0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

262543:EXIG RS08880
gene id: 262543:EXIG_RS08880
uniprot id: B1YHK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS02880
gene id: 262543:EXIG_RS02880
uniprot id: B1YJH7
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS02110
gene id: 262543:EXIG_RS02110
uniprot id: B1YIH7
names: Similarity
messages: Belongs to the glycosyl hydrolase.

262543:EXIG RS15435
gene id: 262543:EXIG_RS15435
uniprot id: B1YG98
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

262543:EXIG RS12535
gene id: 262543:EXIG_RS12535
uniprot id: B1YLK6
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

262543:EXIG RS04005
gene id: 262543:EXIG_RS04005
uniprot id: B1YKN4
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

262543:EXIG RS00595
gene id: 262543:EXIG_RS00595
uniprot id: B1YGT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

262543:EXIG RS10670
gene id: 262543:EXIG_RS10670
uniprot id: B1YJF9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

262543:EXIG RS07120
gene id: 262543:EXIG_RS07120
uniprot id: B1YFG2
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS09645
gene id: 262543:EXIG_RS09645
uniprot id: B1YIA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.

262543:EXIG RS10900
gene id: 262543:EXIG_RS10900
uniprot id: B1YJU9
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

262543:EXIG RS04755
gene id: 262543:EXIG_RS04755
uniprot id: B1YLD2
names: Function
messages: Required for transformation and DNA binding.

262543:EXIG RS02710
gene id: 262543:EXIG_RS02710
uniprot id: B1YJ46
names: Similarity
messages: Belongs to the ABC transporter superfamily.

262543:EXIG RS04640
gene id: 262543:EXIG_RS04640
uniprot id: B1YLA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

262543:EXIG RS09315
gene id: 262543:EXIG_RS09315
uniprot id: B1YI39
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

262543:EXIG RS04945
gene id: 262543:EXIG_RS04945
uniprot id: B1YLR9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

262543:EXIG RS10175
gene id: 262543:EXIG_RS10175
uniprot id: B1YIW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS04805
gene id: 262543:EXIG_RS04805
uniprot id: B1YLP1
names: Similarity
messages: Belongs to the DtxR/MntR family.

262543:EXIG RS12830
gene id: 262543:EXIG_RS12830
uniprot id: B1YM12
names: Similarity
messages: Belongs to the UPF0637 family.

262543:EXIG RS06070
gene id: 262543:EXIG_RS06070
uniprot id: B1YEC8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CutC family.
messages: Cytoplasm
messages: Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case.

262543:EXIG RS05075
gene id: 262543:EXIG_RS05075
uniprot id: B1YLU6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

262543:EXIG RS01150
gene id: 262543:EXIG_RS01150
uniprot id: B1YHD4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
messages: Homotetramer.

262543:EXIG RS01130
gene id: 262543:EXIG_RS01130
uniprot id: B1YHD0
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS04500
gene id: 262543:EXIG_RS04500
uniprot id: B1YL83
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

262543:EXIG RS09740
gene id: 262543:EXIG_RS09740
uniprot id: B1YIM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

262543:EXIG RS05915
gene id: 262543:EXIG_RS05915
uniprot id: B1YE95
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS03190
gene id: 262543:EXIG_RS03190
uniprot id: B1YJN9
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS06460
gene id: 262543:EXIG_RS06460
uniprot id: B1YEV1
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS00315
gene id: 262543:EXIG_RS00315
uniprot id: B1YGP3
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

262543:EXIG RS08050
gene id: 262543:EXIG_RS08050
uniprot id: B1YGL1
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

262543:EXIG RS10560
gene id: 262543:EXIG_RS10560
uniprot id: B1YJD6
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
messages: Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.

262543:EXIG RS05725
gene id: 262543:EXIG_RS05725
uniprot id: B1YMH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

262543:EXIG RS03365
gene id: 262543:EXIG_RS03365
uniprot id: B1YK24
names: Function
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily.
messages: Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA).

262543:EXIG RS00310
gene id: 262543:EXIG_RS00310
uniprot id: B1YGP2
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

262543:EXIG RS07695
gene id: 262543:EXIG_RS07695
uniprot id: B1YG16
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

262543:EXIG RS03765
gene id: 262543:EXIG_RS03765
uniprot id: B1YK87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PrsA family.
messages: Cell membrane
messages: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins.

262543:EXIG RS06220
gene id: 262543:EXIG_RS06220
uniprot id: B1YEF9
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS10565
gene id: 262543:EXIG_RS10565
uniprot id: B1YJD7
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

262543:EXIG RS13765
gene id: 262543:EXIG_RS13765
uniprot id: B1YEJ0
names: Cofactor
names: Similarity
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.

262543:EXIG RS09500
gene id: 262543:EXIG_RS09500
uniprot id: B1YI75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

262543:EXIG RS05175
gene id: 262543:EXIG_RS05175
uniprot id: B1YLW6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

262543:EXIG RS05900
gene id: 262543:EXIG_RS05900
uniprot id: B1YE92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

262543:EXIG RS04880
gene id: 262543:EXIG_RS04880
uniprot id: B1YLQ6
names: Similarity
messages: Belongs to the TlyA family.

262543:EXIG RS03770
gene id: 262543:EXIG_RS03770
uniprot id: B1YK88
names: Function
names: Subunit
messages: Homodimer.
messages: Negative regulator of protease production and sporulation.

262543:EXIG RS02545
gene id: 262543:EXIG_RS02545
uniprot id: B1YJ13
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS10915
gene id: 262543:EXIG_RS10915
uniprot id: B1YJV2
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

262543:EXIG RS13065
gene id: 262543:EXIG_RS13065
uniprot id: B1YM58
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

262543:EXIG RS11265
gene id: 262543:EXIG_RS11265
uniprot id: B1YKA6
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Belongs to the LDH/MDH superfamily. MDH type 3 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

262543:EXIG RS03310
gene id: 262543:EXIG_RS03310
uniprot id: B1YK13
names: Domain
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

262543:EXIG RS06510
gene id: 262543:EXIG_RS06510
uniprot id: B1YEV9
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

262543:EXIG RS09415
gene id: 262543:EXIG_RS09415
uniprot id: B1YI58
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

262543:EXIG RS00075
gene id: 262543:EXIG_RS00075
uniprot id: B1YGC3
names: Function
names: Similarity
messages: Belongs to the peptidase S11 family.
messages: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.

262543:EXIG RS04455
gene id: 262543:EXIG_RS04455
uniprot id: B1YL74
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

262543:EXIG RS01155
gene id: 262543:EXIG_RS01155
uniprot id: B1YHD5
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS09385
gene id: 262543:EXIG_RS09385
uniprot id: B1YI52
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

262543:EXIG RS04175
gene id: 262543:EXIG_RS04175
uniprot id: B1YKR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

262543:EXIG RS01200
gene id: 262543:EXIG_RS01200
uniprot id: B1YHE4
names: Function
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Catalyzes the NADPH dependent reduction of D-ribulose 5-phosphate to D-ribitol 5-phosphate.

262543:EXIG RS12445
gene id: 262543:EXIG_RS12445
uniprot id: B1YLI8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

262543:EXIG RS13990
gene id: 262543:EXIG_RS13990
uniprot id: B1YEN7
names: Similarity
messages: Belongs to the WrbA family.

262543:EXIG RS01740
gene id: 262543:EXIG_RS01740
uniprot id: B1YI02
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

262543:EXIG RS01010
gene id: 262543:EXIG_RS01010
uniprot id: B1YHA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

262543:EXIG RS14450
gene id: 262543:EXIG_RS14450
uniprot id: B1YF57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

262543:EXIG RS10035
gene id: 262543:EXIG_RS10035
uniprot id: B1YIT3
names: Similarity
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.

262543:EXIG RS05665
gene id: 262543:EXIG_RS05665
uniprot id: B1YMG1
names: Similarity
messages: Belongs to the peptidase C40 family.

262543:EXIG RS09570
gene id: 262543:EXIG_RS09570
uniprot id: B1YI89
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

262543:EXIG RS00705
gene id: 262543:EXIG_RS00705
uniprot id: B1YGV7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

262543:EXIG RS14830
gene id: 262543:EXIG_RS14830
uniprot id: B1YFN3
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS14520
gene id: 262543:EXIG_RS14520
uniprot id: B1YF71
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS10950
gene id: 262543:EXIG_RS10950
uniprot id: B1YJV9
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

262543:EXIG RS12720
gene id: 262543:EXIG_RS12720
uniprot id: B1YLZ0
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

262543:EXIG RS07020
gene id: 262543:EXIG_RS07020
uniprot id: B1YFE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS12735
gene id: 262543:EXIG_RS12735
uniprot id: B1YLZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

262543:EXIG RS02930
gene id: 262543:EXIG_RS02930
uniprot id: B1YJI8
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

262543:EXIG RS13160
gene id: 262543:EXIG_RS13160
uniprot id: B1YM78
names: Similarity
messages: Belongs to the LOG family.

262543:EXIG RS04440
gene id: 262543:EXIG_RS04440
uniprot id: B1YL71
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane
messages: Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents.

262543:EXIG RS09730
gene id: 262543:EXIG_RS09730
uniprot id: B1YIM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS03180
gene id: 262543:EXIG_RS03180
uniprot id: B1YJN7
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.

262543:EXIG RS00600
gene id: 262543:EXIG_RS00600
uniprot id: B1YGT6
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

262543:EXIG RS03750
gene id: 262543:EXIG_RS03750
uniprot id: B1YK84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

262543:EXIG RS09610
gene id: 262543:EXIG_RS09610
uniprot id: B1YI97
names: Similarity
messages: Belongs to the FlgD family.

262543:EXIG RS05320
gene id: 262543:EXIG_RS05320
uniprot id: B1YM92
names: Similarity
messages: Belongs to the Nudix hydrolase family.

262543:EXIG RS05780
gene id: 262543:EXIG_RS05780
uniprot id: B1YE68
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the FGGY kinase family.
messages: Homotetramer and homodimer (in equilibrium).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), including enzyme I, and histidine-containing protein (HPr) are required for the phosphorylation, which leads to the activation of the enzyme.

262543:EXIG RS06175
gene id: 262543:EXIG_RS06175
uniprot id: B1YEF0
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

262543:EXIG RS06170
gene id: 262543:EXIG_RS06170
uniprot id: B1YEE9
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit A family.

262543:EXIG RS09320
gene id: 262543:EXIG_RS09320
uniprot id: B1YI40
names: Similarity
messages: Belongs to the MecA family.

262543:EXIG RS12050
gene id: 262543:EXIG_RS12050
uniprot id: B1YL13
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.

262543:EXIG RS12985
gene id: 262543:EXIG_RS12985
uniprot id: B1YM42
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpA family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

262543:EXIG RS04465
gene id: 262543:EXIG_RS04465
uniprot id: B1YL76
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

262543:EXIG RS09700
gene id: 262543:EXIG_RS09700
uniprot id: B1YIL6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

262543:EXIG RS10910
gene id: 262543:EXIG_RS10910
uniprot id: B1YJV1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

262543:EXIG RS13385
gene id: 262543:EXIG_RS13385
uniprot id: B1YMM2
names: Similarity
messages: Belongs to the polysaccharide synthase family.

262543:EXIG RS02365
gene id: 262543:EXIG_RS02365
uniprot id: B1YIY0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the aldolase class II family. MtnB subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).

262543:EXIG RS14320
gene id: 262543:EXIG_RS14320
uniprot id: B1YF31
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

262543:EXIG RS10505
gene id: 262543:EXIG_RS10505
uniprot id: B1YJC5
names: Similarity
messages: Belongs to the ABC transporter superfamily.

262543:EXIG RS04480
gene id: 262543:EXIG_RS04480
uniprot id: B1YL79
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

262543:EXIG RS12530
gene id: 262543:EXIG_RS12530
uniprot id: B1YLK5
names: Similarity
messages: Belongs to the bacterial flagellin family.

262543:EXIG RS08835
gene id: 262543:EXIG_RS08835
uniprot id: B1YHJ8
names: Similarity
messages: Belongs to the mannitol dehydrogenase family.

262543:EXIG RS00800
gene id: 262543:EXIG_RS00800
uniprot id: B1YGX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

262543:EXIG RS04965
gene id: 262543:EXIG_RS04965
uniprot id: B1YLS3
names: Similarity
messages: Belongs to the TrpF family.

262543:EXIG RS02630
gene id: 262543:EXIG_RS02630
uniprot id: B1YJ30
names: Function
names: Similarity
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.
messages: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.

262543:EXIG RS09015
gene id: 262543:EXIG_RS09015
uniprot id: B1YHN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

262543:EXIG RS13595
gene id: 262543:EXIG_RS13595
uniprot id: B1YMR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

262543:EXIG RS09890
gene id: 262543:EXIG_RS09890
uniprot id: B1YIQ4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

262543:EXIG RS03535
gene id: 262543:EXIG_RS03535
uniprot id: B1YK58
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

262543:EXIG RS10305
gene id: 262543:EXIG_RS10305
uniprot id: B1YJ84
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

262543:EXIG RS01005
gene id: 262543:EXIG_RS01005
uniprot id: B1YHA6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

262543:EXIG RS13390
gene id: 262543:EXIG_RS13390
uniprot id: B1YMM3
names: Similarity
messages: Belongs to the UDPGP type 2 family.

262543:EXIG RS04940
gene id: 262543:EXIG_RS04940
uniprot id: B1YLR8
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

262543:EXIG RS02605
gene id: 262543:EXIG_RS02605
uniprot id: B1YJ25
names: Similarity
names: Subunit
messages: Belongs to the glutaminase family.
messages: Homotetramer.

262543:EXIG RS11400
gene id: 262543:EXIG_RS11400
uniprot id: B1YKD3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

262543:EXIG RS04920
gene id: 262543:EXIG_RS04920
uniprot id: B1YLR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetokinase family.
messages: Cytoplasm

262543:EXIG RS01495
gene id: 262543:EXIG_RS01495
uniprot id: B1YHV3
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

262543:EXIG RS00685
gene id: 262543:EXIG_RS00685
uniprot id: B1YGV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

262543:EXIG RS02065
gene id: 262543:EXIG_RS02065
uniprot id: B1YIG8
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS01380
gene id: 262543:EXIG_RS01380
uniprot id: B1YHT0
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS04300
gene id: 262543:EXIG_RS04300
uniprot id: B1YL43
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS10845
gene id: 262543:EXIG_RS10845
uniprot id: B1YJT8
names: Similarity
messages: Belongs to the GSP E family.

262543:EXIG RS11465
gene id: 262543:EXIG_RS11465
uniprot id: B1YKE6
names: Similarity
messages: Belongs to the Dps family.

262543:EXIG RS09605
gene id: 262543:EXIG_RS09605
uniprot id: B1YI96
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

262543:EXIG RS12255
gene id: 262543:EXIG_RS12255
uniprot id: B1YLF0
names: Function
names: Similarity
messages: Belongs to the RapZ-like family.
messages: Displays ATPase and GTPase activities.

262543:EXIG RS15415
gene id: 262543:EXIG_RS15415
uniprot id: B1YG94
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

262543:EXIG RS04385
gene id: 262543:EXIG_RS04385
uniprot id: B1YL61
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

262543:EXIG RS13565
gene id: 262543:EXIG_RS13565
uniprot id: B1YMQ8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

262543:EXIG RS00745
gene id: 262543:EXIG_RS00745
uniprot id: B1YGW5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

262543:EXIG RS11170
gene id: 262543:EXIG_RS11170
uniprot id: B1YK02
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

262543:EXIG RS04270
gene id: 262543:EXIG_RS04270
uniprot id: B1YKT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

262543:EXIG RS09810
gene id: 262543:EXIG_RS09810
uniprot id: B1YIN8
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).

262543:EXIG RS06185
gene id: 262543:EXIG_RS06185
uniprot id: B1YEF2
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

262543:EXIG RS11620
gene id: 262543:EXIG_RS11620
uniprot id: B1YKH7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

262543:EXIG RS01070
gene id: 262543:EXIG_RS01070
uniprot id: B1YHB9
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

262543:EXIG RS06120
gene id: 262543:EXIG_RS06120
uniprot id: B1YED8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0073 (Hly-III) family.
messages: Membrane

262543:EXIG RS01115
gene id: 262543:EXIG_RS01115
uniprot id: B1YHC7
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS10420
gene id: 262543:EXIG_RS10420
uniprot id: B1YJA7
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. YjcG family.

262543:EXIG RS09595
gene id: 262543:EXIG_RS09595
uniprot id: B1YI94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

262543:EXIG RS13610
gene id: 262543:EXIG_RS13610
uniprot id: B1YMR7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

262543:EXIG RS08950
gene id: 262543:EXIG_RS08950
uniprot id: B1YHL8
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

262543:EXIG RS04390
gene id: 262543:EXIG_RS04390
uniprot id: B1YL62
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

262543:EXIG RS13470
gene id: 262543:EXIG_RS13470
uniprot id: B1YMN9
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

262543:EXIG RS15270
gene id: 262543:EXIG_RS15270
uniprot id: B1YG64
names: Similarity
messages: Belongs to the MQO family.

262543:EXIG RS11730
gene id: 262543:EXIG_RS11730
uniprot id: B1YKU9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

262543:EXIG RS07455
gene id: 262543:EXIG_RS07455
uniprot id: B1YFX1
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

262543:EXIG RS13105
gene id: 262543:EXIG_RS13105
uniprot id: B1YM66
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS03830
gene id: 262543:EXIG_RS03830
uniprot id: B1YKJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Cytoplasm
messages: Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.

262543:EXIG RS00615
gene id: 262543:EXIG_RS00615
uniprot id: B1YGT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

262543:EXIG RS04225
gene id: 262543:EXIG_RS04225
uniprot id: B1YKS7
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

262543:EXIG RS11745
gene id: 262543:EXIG_RS11745
uniprot id: B1YKV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

262543:EXIG RS02675
gene id: 262543:EXIG_RS02675
uniprot id: B1YJ39
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

262543:EXIG RS04645
gene id: 262543:EXIG_RS04645
uniprot id: B1YLB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

262543:EXIG RS09490
gene id: 262543:EXIG_RS09490
uniprot id: B1YI73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

262543:EXIG RS10280
gene id: 262543:EXIG_RS10280
uniprot id: B1YJ79
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

262543:EXIG RS05895
gene id: 262543:EXIG_RS05895
uniprot id: B1YE91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. TCR/Tet family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS01875
gene id: 262543:EXIG_RS01875
uniprot id: B1YE98
names: Function
names: Similarity
messages: Belongs to the transposase IS30 family.
messages: Required for the transposition of the insertion element.

262543:EXIG RS03055
gene id: 262543:EXIG_RS03055
uniprot id: B1YJL2
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

262543:EXIG RS00930
gene id: 262543:EXIG_RS00930
uniprot id: B1YH91
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

262543:EXIG RS11535
gene id: 262543:EXIG_RS11535
uniprot id: B1YKG0
names: Similarity
messages: Belongs to the TPP enzyme family.

262543:EXIG RS11055
gene id: 262543:EXIG_RS11055
uniprot id: B1YJX9
names: Cofactor
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.

262543:EXIG RS09430
gene id: 262543:EXIG_RS09430
uniprot id: B1YI61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

262543:EXIG RS05210
gene id: 262543:EXIG_RS05210
uniprot id: B1YLX3
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

262543:EXIG RS02890
gene id: 262543:EXIG_RS02890
uniprot id: B1YJH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

262543:EXIG RS13170
gene id: 262543:EXIG_RS13170
uniprot id: B1YMH8
names: Similarity
messages: Belongs to the ABC transporter superfamily.

262543:EXIG RS12345
gene id: 262543:EXIG_RS12345
uniprot id: B1YLG8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

262543:EXIG RS01600
gene id: 262543:EXIG_RS01600
uniprot id: B1YHX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0053 family.
messages: Membrane

262543:EXIG RS01620
gene id: 262543:EXIG_RS01620
uniprot id: B1YHX9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

262543:EXIG RS12395
gene id: 262543:EXIG_RS12395
uniprot id: B1YLH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
messages: Secreted

262543:EXIG RS06160
gene id: 262543:EXIG_RS06160
uniprot id: B1YEE7
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS11085
gene id: 262543:EXIG_RS11085
uniprot id: B1YJY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
messages: Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
messages: Homodimer.

262543:EXIG RS10990
gene id: 262543:EXIG_RS10990
uniprot id: B1YJW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

262543:EXIG RS10650
gene id: 262543:EXIG_RS10650
uniprot id: B1YJF4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.
messages: Binds 1 FAD per subunit.
messages: May have a photoreceptor function.

262543:EXIG RS01490
gene id: 262543:EXIG_RS01490
uniprot id: B1YHV2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.

262543:EXIG RS00390
gene id: 262543:EXIG_RS00390
uniprot id: B1YGQ6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

262543:EXIG RS01320
gene id: 262543:EXIG_RS01320
uniprot id: B1YHR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0382 family.
messages: Membrane

262543:EXIG RS12055
gene id: 262543:EXIG_RS12055
uniprot id: B1YL14
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

262543:EXIG RS01340
gene id: 262543:EXIG_RS01340
uniprot id: B1YHS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

262543:EXIG RS00555
gene id: 262543:EXIG_RS00555
uniprot id: B1YGS7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

262543:EXIG RS05490
gene id: 262543:EXIG_RS05490
uniprot id: B1YMC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
messages: Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
messages: Homodimer.

262543:EXIG RS04980
gene id: 262543:EXIG_RS04980
uniprot id: B1YLS6
names: Similarity
messages: Belongs to the transpeptidase family.

262543:EXIG RS02975
gene id: 262543:EXIG_RS02975
uniprot id: B1YJJ7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

262543:EXIG RS02095
gene id: 262543:EXIG_RS02095
uniprot id: B1YIH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS10330
gene id: 262543:EXIG_RS10330
uniprot id: B1YJ89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 1 family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS08750
gene id: 262543:EXIG_RS08750
uniprot id: B1YHI2
names: Similarity
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit G family.

262543:EXIG RS09475
gene id: 262543:EXIG_RS09475
uniprot id: B1YI70
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).

262543:EXIG RS06955
gene id: 262543:EXIG_RS06955
uniprot id: B1YFC9
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS00525
gene id: 262543:EXIG_RS00525
uniprot id: B1YGS1
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

262543:EXIG RS05345
gene id: 262543:EXIG_RS05345
uniprot id: B1YM97
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.
messages: Homodimer.

262543:EXIG RS07285
gene id: 262543:EXIG_RS07285
uniprot id: B1YFU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

262543:EXIG RS07015
gene id: 262543:EXIG_RS07015
uniprot id: B1YFE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS11705
gene id: 262543:EXIG_RS11705
uniprot id: B1YKU4
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

262543:EXIG RS00560
gene id: 262543:EXIG_RS00560
uniprot id: B1YGS8
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

262543:EXIG RS13165
gene id: 262543:EXIG_RS13165
uniprot id: B1YMH7
names: Similarity
messages: Belongs to the UDPGP type 2 family.

262543:EXIG RS09885
gene id: 262543:EXIG_RS09885
uniprot id: B1YIQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

262543:EXIG RS00060
gene id: 262543:EXIG_RS00060
uniprot id: B1YGC0
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

262543:EXIG RS09690
gene id: 262543:EXIG_RS09690
uniprot id: B1YIB3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

262543:EXIG RS01220
gene id: 262543:EXIG_RS01220
uniprot id: B1YHE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. EmrB family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS08545
gene id: 262543:EXIG_RS08545
uniprot id: B1YH55
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS04960
gene id: 262543:EXIG_RS04960
uniprot id: B1YLS2
names: Similarity
messages: Belongs to the TrpC family.

262543:EXIG RS15455
gene id: 262543:EXIG_RS15455
uniprot id: B1YGA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

262543:EXIG RS13450
gene id: 262543:EXIG_RS13450
uniprot id: B1YMN5
names: Function
names: Similarity
messages: Belongs to the transposase IS30 family.
messages: Required for the transposition of the insertion element.

262543:EXIG RS00665
gene id: 262543:EXIG_RS00665
uniprot id: B1YGU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

262543:EXIG RS09425
gene id: 262543:EXIG_RS09425
uniprot id: B1YI60
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

262543:EXIG RS11035
gene id: 262543:EXIG_RS11035
uniprot id: B1YJX5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

262543:EXIG RS05290
gene id: 262543:EXIG_RS05290
uniprot id: B1YM86
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

262543:EXIG RS00340
gene id: 262543:EXIG_RS00340
uniprot id: B1YGP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

262543:EXIG RS09485
gene id: 262543:EXIG_RS09485
uniprot id: B1YI72
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

262543:EXIG RS10590
gene id: 262543:EXIG_RS10590
uniprot id: B1YJE2
names: Similarity
messages: Belongs to the UPF0473 family.

262543:EXIG RS00080
gene id: 262543:EXIG_RS00080
uniprot id: B1YGC4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

262543:EXIG RS09560
gene id: 262543:EXIG_RS09560
uniprot id: B1YI87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

262543:EXIG RS12685
gene id: 262543:EXIG_RS12685
uniprot id: B1YLY3
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS13680
gene id: 262543:EXIG_RS13680
uniprot id: B1YEH3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

262543:EXIG RS14180
gene id: 262543:EXIG_RS14180
uniprot id: B1YF17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS14570
gene id: 262543:EXIG_RS14570
uniprot id: B1YFI1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

262543:EXIG RS08675
gene id: 262543:EXIG_RS08675
uniprot id: B1YH77
names: Subcellular Location Annotation
messages: Cytoplasm

262543:EXIG RS01625
gene id: 262543:EXIG_RS01625
uniprot id: B1YHY0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

262543:EXIG RS02530
gene id: 262543:EXIG_RS02530
uniprot id: B1YJ10
names: Similarity
messages: Belongs to the GARS family.

262543:EXIG RS14550
gene id: 262543:EXIG_RS14550
uniprot id: B1YF78
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

262543:EXIG RS03085
gene id: 262543:EXIG_RS03085
uniprot id: B1YJL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

262543:EXIG RS11470
gene id: 262543:EXIG_RS11470
uniprot id: B1YKE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0316 family.
messages: Cell membrane

262543:EXIG RS10200
gene id: 262543:EXIG_RS10200
uniprot id: B1YIW7
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase family.
messages: Binds 1 FAD per subunit.

262543:EXIG RS15490
gene id: 262543:EXIG_RS15490
uniprot id: B1YGA9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
messages: Cell membrane
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.

262543:EXIG RS09130
gene id: 262543:EXIG_RS09130
uniprot id: B1YHQ6
names: Function
names: Similarity
messages: 3'-5' exonuclease.
messages: Belongs to the helicase family. DinG subfamily. Type 2 sub-subfamily.

262543:EXIG RS09470
gene id: 262543:EXIG_RS09470
uniprot id: B1YI69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

262543:EXIG RS14130
gene id: 262543:EXIG_RS14130
uniprot id: B1YF07
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

262543:EXIG RS02250
gene id: 262543:EXIG_RS02250
uniprot id: B1YIK5
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

262543:EXIG RS12260
gene id: 262543:EXIG_RS12260
uniprot id: B1YLF1
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

262543:EXIG RS02760
gene id: 262543:EXIG_RS02760
uniprot id: B1YJ56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily.
messages: Catalyzes the interconversion of ornithine to glutamate semialdehyde.
messages: Cytoplasm

262543:EXIG RS06500
gene id: 262543:EXIG_RS06500
uniprot id: B1YEV7
names: Similarity
messages: Belongs to the DinB family.

262543:EXIG RS05595
gene id: 262543:EXIG_RS05595
uniprot id: B1YME7
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS09970
gene id: 262543:EXIG_RS09970
uniprot id: B1YIS0
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

262543:EXIG RS07780
gene id: 262543:EXIG_RS07780
uniprot id: B1YGF7
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS04875
gene id: 262543:EXIG_RS04875
uniprot id: B1YLQ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

262543:EXIG RS00565
gene id: 262543:EXIG_RS00565
uniprot id: B1YGS9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

262543:EXIG RS00385
gene id: 262543:EXIG_RS00385
uniprot id: B1YGQ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

262543:EXIG RS02105
gene id: 262543:EXIG_RS02105
uniprot id: B1YIH6
names: Similarity
messages: Belongs to the glycosyl hydrolase 42 family.

262543:EXIG RS14495
gene id: 262543:EXIG_RS14495
uniprot id: B1YF66
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS07365
gene id: 262543:EXIG_RS07365
uniprot id: B1YFV6
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

262543:EXIG RS12745
gene id: 262543:EXIG_RS12745
uniprot id: B1YLZ5
names: Similarity
messages: Belongs to the CDP-glycerol glycerophosphotransferase family.

262543:EXIG RS13695
gene id: 262543:EXIG_RS13695
uniprot id: B1YEH6
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

262543:EXIG RS03185
gene id: 262543:EXIG_RS03185
uniprot id: B1YJN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

262543:EXIG RS07640
gene id: 262543:EXIG_RS07640
uniprot id: B1YG06
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

262543:EXIG RS14590
gene id: 262543:EXIG_RS14590
uniprot id: B1YFI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS10895
gene id: 262543:EXIG_RS10895
uniprot id: B1YJU8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

262543:EXIG RS11900
gene id: 262543:EXIG_RS11900
uniprot id: B1YKY2
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

262543:EXIG RS02380
gene id: 262543:EXIG_RS02380
uniprot id: B1YIY3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methylthioribose kinase family.
messages: Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate.
messages: Homodimer.

262543:EXIG RS00270
gene id: 262543:EXIG_RS00270
uniprot id: B1YGE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

262543:EXIG RS06435
gene id: 262543:EXIG_RS06435
uniprot id: B1YEU6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

262543:EXIG RS01145
gene id: 262543:EXIG_RS01145
uniprot id: B1YHD3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Cyclase 1 superfamily. KynB family.
messages: Binds 2 zinc ions per subunit.
messages: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.
messages: Homodimer.

262543:EXIG RS01345
gene id: 262543:EXIG_RS01345
uniprot id: B1YHS3
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS15495
gene id: 262543:EXIG_RS15495
uniprot id: B1YGB0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

262543:EXIG RS02925
gene id: 262543:EXIG_RS02925
uniprot id: B1YJI7
names: Caution
names: Similarity
messages: Belongs to the peptidase C56 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

262543:EXIG RS15445
gene id: 262543:EXIG_RS15445
uniprot id: B1YGA0
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

262543:EXIG RS11225
gene id: 262543:EXIG_RS11225
uniprot id: B1YK98
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

262543:EXIG RS14345
gene id: 262543:EXIG_RS14345
uniprot id: B1YF36
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

262543:EXIG RS00320
gene id: 262543:EXIG_RS00320
uniprot id: B1YGP4
names: Function
names: Similarity
messages: Belongs to the SpoVG family.
messages: Could be involved in septation.

262543:EXIG RS11090
gene id: 262543:EXIG_RS11090
uniprot id: B1YJY6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

262543:EXIG RS15305
gene id: 262543:EXIG_RS15305
uniprot id: B1YG70
names: Similarity
messages: Belongs to the LOR family.

262543:EXIG RS15255
gene id: 262543:EXIG_RS15255
uniprot id: B1YG61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

262543:EXIG RS15425
gene id: 262543:EXIG_RS15425
uniprot id: B1YG96
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GdpP/PdeA phosphodiesterase family.
messages: Cell membrane
messages: For phosphodiesterase activity, probably binds 2 Mn(2+) per subunit.
messages: Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP).

262543:EXIG RS11140
gene id: 262543:EXIG_RS11140
uniprot id: B1YJZ6
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS11385
gene id: 262543:EXIG_RS11385
uniprot id: B1YKD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EzrA family.
messages: Cell membrane
messages: Membrane
messages: Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization.

262543:EXIG RS00680
gene id: 262543:EXIG_RS00680
uniprot id: B1YGV2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

262543:EXIG RS12885
gene id: 262543:EXIG_RS12885
uniprot id: B1YM23
names: Similarity
messages: Belongs to the zinc-associated anti-sigma factor (ZAS) superfamily. Anti-sigma-W factor family.

262543:EXIG RS00955
gene id: 262543:EXIG_RS00955
uniprot id: B1YH96
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

262543:EXIG RS06085
gene id: 262543:EXIG_RS06085
uniprot id: B1YED1
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS11990
gene id: 262543:EXIG_RS11990
uniprot id: B1YL01
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

262543:EXIG RS11270
gene id: 262543:EXIG_RS11270
uniprot id: B1YKA7
names: Cofactor
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

262543:EXIG RS10785
gene id: 262543:EXIG_RS10785
uniprot id: B1YJS6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MinC family.
messages: Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
messages: Interacts with MinD and FtsZ.

262543:EXIG RS13605
gene id: 262543:EXIG_RS13605
uniprot id: B1YMR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

262543:EXIG RS10335
gene id: 262543:EXIG_RS10335
uniprot id: B1YJ90
names: Function
names: Similarity
messages: Belongs to the peptidase M20A family. N-acetyldiaminopimelate deacetylase subfamily.
messages: Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate.

262543:EXIG RS02665
gene id: 262543:EXIG_RS02665
uniprot id: B1YJ37
names: Function
names: Similarity
messages: Belongs to the aspartokinase family.
messages: Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine.

262543:EXIG RS04410
gene id: 262543:EXIG_RS04410
uniprot id: B1YL65
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS00110
gene id: 262543:EXIG_RS00110
uniprot id: B1YGC6
names: Similarity
messages: Belongs to the DCK/DGK family.

262543:EXIG RS14675
gene id: 262543:EXIG_RS14675
uniprot id: B1YFK2
names: Similarity
messages: Belongs to the MotB family.

262543:EXIG RS08090
gene id: 262543:EXIG_RS08090
uniprot id: B1YGL9
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS12605
gene id: 262543:EXIG_RS12605
uniprot id: B1YLM0
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS13535
gene id: 262543:EXIG_RS13535
uniprot id: B1YMQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

262543:EXIG RS00545
gene id: 262543:EXIG_RS00545
uniprot id: B1YGS5
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

262543:EXIG RS03905
gene id: 262543:EXIG_RS03905
uniprot id: B1YKL3
names: Activity Regulation
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the FGGY kinase family.
messages: Homotetramer and homodimer (in equilibrium).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), including enzyme I, and histidine-containing protein (HPr) are required for the phosphorylation, which leads to the activation of the enzyme.

262543:EXIG RS12370
gene id: 262543:EXIG_RS12370
uniprot id: B1YLH3
names: Subcellular Location Annotation
messages: Cytoplasm

262543:EXIG RS11695
gene id: 262543:EXIG_RS11695
uniprot id: B1YKU2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

262543:EXIG RS05165
gene id: 262543:EXIG_RS05165
uniprot id: B1YLW4
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS06195
gene id: 262543:EXIG_RS06195
uniprot id: B1YEF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS14300
gene id: 262543:EXIG_RS14300
uniprot id: B1YF27
names: Function
names: Similarity
messages: Belongs to the anti-sigma-factor family.
messages: Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B).

262543:EXIG RS01610
gene id: 262543:EXIG_RS01610
uniprot id: B1YHX7
names: Similarity
messages: Belongs to the aldose epimerase family.

262543:EXIG RS00655
gene id: 262543:EXIG_RS00655
uniprot id: B1YGU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

262543:EXIG RS02435
gene id: 262543:EXIG_RS02435
uniprot id: B1YIZ4
names: Similarity
messages: Belongs to the acyltransferase 3 family.

262543:EXIG RS02495
gene id: 262543:EXIG_RS02495
uniprot id: B1YJ03
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

262543:EXIG RS00765
gene id: 262543:EXIG_RS00765
uniprot id: B1YGW9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

262543:EXIG RS12515
gene id: 262543:EXIG_RS12515
uniprot id: B1YLK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

262543:EXIG RS09750
gene id: 262543:EXIG_RS09750
uniprot id: B1YIM6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

262543:EXIG RS01325
gene id: 262543:EXIG_RS01325
uniprot id: B1YHR9
names: Similarity
messages: Belongs to the ChdC family. Type 1 subfamily.

262543:EXIG RS00855
gene id: 262543:EXIG_RS00855
uniprot id: B1YH88
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

262543:EXIG RS14760
gene id: 262543:EXIG_RS14760
uniprot id: B1YFL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

262543:EXIG RS10045
gene id: 262543:EXIG_RS10045
uniprot id: B1YIT5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

262543:EXIG RS09455
gene id: 262543:EXIG_RS09455
uniprot id: B1YI66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

262543:EXIG RS00010
gene id: 262543:EXIG_RS00010
uniprot id: B1YGB3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

262543:EXIG RS09435
gene id: 262543:EXIG_RS09435
uniprot id: B1YI62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

262543:EXIG RS10110
gene id: 262543:EXIG_RS10110
uniprot id: B1YIU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TmcAL family.
messages: Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
messages: Cytoplasm

262543:EXIG RS07220
gene id: 262543:EXIG_RS07220
uniprot id: B1YFT0
names: Caution
names: Similarity
messages: Belongs to the globin family.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

262543:EXIG RS00590
gene id: 262543:EXIG_RS00590
uniprot id: B1YGT4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

262543:EXIG RS03100
gene id: 262543:EXIG_RS03100
uniprot id: B1YJM2
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

262543:EXIG RS11560
gene id: 262543:EXIG_RS11560
uniprot id: B1YKG5
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

262543:EXIG RS14185
gene id: 262543:EXIG_RS14185
uniprot id: B1YF18
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.

262543:EXIG RS01180
gene id: 262543:EXIG_RS01180
uniprot id: B1YHE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. TCR/Tet family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS00005
gene id: 262543:EXIG_RS00005
uniprot id: B1YGB2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

262543:EXIG RS11285
gene id: 262543:EXIG_RS11285
uniprot id: B1YKB0
names: Similarity
messages: Belongs to the pyruvate kinase family.
messages: In the C-terminal section; belongs to the PEP-utilizing enzyme family.

262543:EXIG RS07965
gene id: 262543:EXIG_RS07965
uniprot id: B1YGJ3
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS08740
gene id: 262543:EXIG_RS08740
uniprot id: B1YHI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS14465
gene id: 262543:EXIG_RS14465
uniprot id: B1YF60
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

262543:EXIG RS04780
gene id: 262543:EXIG_RS04780
uniprot id: B1YLN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvT family.
messages: The glycine cleavage system catalyzes the degradation of glycine.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

262543:EXIG RS03245
gene id: 262543:EXIG_RS03245
uniprot id: B1YJQ1
names: Subcellular Location Annotation
messages: Cell membrane

262543:EXIG RS12245
gene id: 262543:EXIG_RS12245
uniprot id: B1YLE8
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

262543:EXIG RS02535
gene id: 262543:EXIG_RS02535
uniprot id: B1YJ11
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

262543:EXIG RS10190
gene id: 262543:EXIG_RS10190
uniprot id: B1YIW5
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Interacts with CtaA.

262543:EXIG RS14405
gene id: 262543:EXIG_RS14405
uniprot id: B1YF48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS10955
gene id: 262543:EXIG_RS10955
uniprot id: B1YJW0
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

262543:EXIG RS03735
gene id: 262543:EXIG_RS03735
uniprot id: B1YK81
names: Similarity
messages: Belongs to the UPF0342 family.

262543:EXIG RS08670
gene id: 262543:EXIG_RS08670
uniprot id: B1YH76
names: Subcellular Location Annotation
messages: Cytoplasm

262543:EXIG RS01950
gene id: 262543:EXIG_RS01950
uniprot id: B1YIE5
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the NOS family. Bacterial NOS oxygenase subfamily.
messages: Catalyzes the production of nitric oxide.
messages: Homodimer.
messages: This protein is similar to the oxygenase domain of eukaryotic nitric oxide synthases but lacks the reductase domain which, in eukaryotes, is responsible for transfer of electrons to the ferric heme during nitric oxide synthesis.

262543:EXIG RS15135
gene id: 262543:EXIG_RS15135
uniprot id: B1YG37
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS09105
gene id: 262543:EXIG_RS09105
uniprot id: B1YHQ0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

262543:EXIG RS12595
gene id: 262543:EXIG_RS12595
uniprot id: B1YLL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

262543:EXIG RS13040
gene id: 262543:EXIG_RS13040
uniprot id: B1YM53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AmiS/UreI family.
messages: Membrane

262543:EXIG RS01135
gene id: 262543:EXIG_RS01135
uniprot id: B1YHD1
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS13550
gene id: 262543:EXIG_RS13550
uniprot id: B1YMQ5
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

262543:EXIG RS14615
gene id: 262543:EXIG_RS14615
uniprot id: B1YFJ0
names: Cofactor
names: Similarity
messages: Belongs to the AlaDH/PNT family.
messages: Binds 1 Mg(2+) ion per subunit.

262543:EXIG RS00660
gene id: 262543:EXIG_RS00660
uniprot id: B1YGU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

262543:EXIG RS00720
gene id: 262543:EXIG_RS00720
uniprot id: B1YGW0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

262543:EXIG RS09355
gene id: 262543:EXIG_RS09355
uniprot id: B1YI46
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS00815
gene id: 262543:EXIG_RS00815
uniprot id: B1YGX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

262543:EXIG RS10395
gene id: 262543:EXIG_RS10395
uniprot id: B1YJA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched chain amino acid transporter family.
messages: Cell membrane
messages: Component of the transport system for branched-chain amino acids.
messages: Membrane

262543:EXIG RS11235
gene id: 262543:EXIG_RS11235
uniprot id: B1YKA0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
messages: Monomer.

262543:EXIG RS15430
gene id: 262543:EXIG_RS15430
uniprot id: B1YG97
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

262543:EXIG RS00430
gene id: 262543:EXIG_RS00430
uniprot id: B1YGR4
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

262543:EXIG RS02450
gene id: 262543:EXIG_RS02450
uniprot id: B1YIZ7
names: Cofactor
messages: Binds 1 FAD per subunit.

262543:EXIG RS09555
gene id: 262543:EXIG_RS09555
uniprot id: B1YI86
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

262543:EXIG RS02685
gene id: 262543:EXIG_RS02685
uniprot id: B1YJ41
names: Function
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family. DapH subfamily.
messages: Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.

262543:EXIG RS04220
gene id: 262543:EXIG_RS04220
uniprot id: B1YKS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

262543:EXIG RS03715
gene id: 262543:EXIG_RS03715
uniprot id: B1YK77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 3 family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS01160
gene id: 262543:EXIG_RS01160
uniprot id: B1YHD6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
messages: Homodimer.

262543:EXIG RS03530
gene id: 262543:EXIG_RS03530
uniprot id: B1YK57
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS04620
gene id: 262543:EXIG_RS04620
uniprot id: B1YLA5
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

262543:EXIG RS15000
gene id: 262543:EXIG_RS15000
uniprot id: B1YFR8
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS15240
gene id: 262543:EXIG_RS15240
uniprot id: B1YG58
names: Similarity
messages: Belongs to the FGGY kinase family.

262543:EXIG RS03005
gene id: 262543:EXIG_RS03005
uniprot id: B1YJK2
names: Similarity
messages: Belongs to the peptidase M29 family.

262543:EXIG RS03330
gene id: 262543:EXIG_RS03330
uniprot id: B1YK18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DEAD box helicase family. CshA subfamily.
messages: Cytoplasm
messages: DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity.
messages: Oligomerizes, may be a member of the RNA degradosome.

262543:EXIG RS14715
gene id: 262543:EXIG_RS14715
uniprot id: B1YFL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

262543:EXIG RS12330
gene id: 262543:EXIG_RS12330
uniprot id: B1YLG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation.

262543:EXIG RS06945
gene id: 262543:EXIG_RS06945
uniprot id: B1YFC7
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

262543:EXIG RS13230
gene id: 262543:EXIG_RS13230
uniprot id: B1YMJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS13945
gene id: 262543:EXIG_RS13945
uniprot id: B1YEM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

262543:EXIG RS00540
gene id: 262543:EXIG_RS00540
uniprot id: B1YGS4
names: Similarity
messages: Belongs to the ycf81 family.

262543:EXIG RS13580
gene id: 262543:EXIG_RS13580
uniprot id: B1YMR1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

262543:EXIG RS03695
gene id: 262543:EXIG_RS03695
uniprot id: B1YK73
names: Similarity
messages: Belongs to the phosphohexose mutase family.

262543:EXIG RS11975
gene id: 262543:EXIG_RS11975
uniprot id: B1YKZ8
names: Similarity
messages: Belongs to the ArsC family.

262543:EXIG RS09745
gene id: 262543:EXIG_RS09745
uniprot id: B1YIM5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

262543:EXIG RS10050
gene id: 262543:EXIG_RS10050
uniprot id: B1YIT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsQ/DivIB family. DivIB subfamily.
messages: Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex.
messages: Cell membrane

262543:EXIG RS03815
gene id: 262543:EXIG_RS03815
uniprot id: B1YKJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonia transporter channel (TC 1.A.11.2) family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS14805
gene id: 262543:EXIG_RS14805
uniprot id: B1YFM8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

262543:EXIG RS07810
gene id: 262543:EXIG_RS07810
uniprot id: B1YGG4
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

262543:EXIG RS15440
gene id: 262543:EXIG_RS15440
uniprot id: B1YG99
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

262543:EXIG RS10555
gene id: 262543:EXIG_RS10555
uniprot id: B1YJD5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

262543:EXIG RS01015
gene id: 262543:EXIG_RS01015
uniprot id: B1YHA8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

262543:EXIG RS12480
gene id: 262543:EXIG_RS12480
uniprot id: B1YLJ5
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS02660
gene id: 262543:EXIG_RS02660
uniprot id: B1YJ36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

262543:EXIG RS01550
gene id: 262543:EXIG_RS01550
uniprot id: B1YHW4
names: Similarity
messages: Belongs to the TPP enzyme family.

262543:EXIG RS14195
gene id: 262543:EXIG_RS14195
uniprot id: B1YF20
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

262543:EXIG RS06675
gene id: 262543:EXIG_RS06675
uniprot id: B1YEY8
names: Similarity
messages: Belongs to the EamA transporter family.

262543:EXIG RS10475
gene id: 262543:EXIG_RS10475
uniprot id: B1YJB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase D family. Cardiolipin synthase subfamily.
messages: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
messages: Cell membrane
messages: Membrane

262543:EXIG RS10300
gene id: 262543:EXIG_RS10300
uniprot id: B1YJ83
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

262543:EXIG RS13880
gene id: 262543:EXIG_RS13880
uniprot id: B1YEL4
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

262543:EXIG RS01700
gene id: 262543:EXIG_RS01700
uniprot id: B1YHZ4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGMT family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
messages: This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.

262543:EXIG RS15400
gene id: 262543:EXIG_RS15400
uniprot id: B1YG91
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS08510
gene id: 262543:EXIG_RS08510
uniprot id: B1YH48
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

262543:EXIG RS04785
gene id: 262543:EXIG_RS04785
uniprot id: B1YLN7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. N-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

262543:EXIG RS13045
gene id: 262543:EXIG_RS13045
uniprot id: B1YM54
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

262543:EXIG RS13685
gene id: 262543:EXIG_RS13685
uniprot id: B1YEH4
names: Similarity
messages: Belongs to the UPF0340 family.

262543:EXIG RS13840
gene id: 262543:EXIG_RS13840
uniprot id: B1YEK5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

262543:EXIG RS09895
gene id: 262543:EXIG_RS09895
uniprot id: B1YIQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

262543:EXIG RS14085
gene id: 262543:EXIG_RS14085
uniprot id: B1YEZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

262543:EXIG RS04655
gene id: 262543:EXIG_RS04655
uniprot id: B1YLB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

262543:EXIG RS05785
gene id: 262543:EXIG_RS05785
uniprot id: B1YE69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Membrane

262543:EXIG RS06630
gene id: 262543:EXIG_RS06630
uniprot id: B1YEX9
names: Similarity
messages: Belongs to the EamA transporter family.

262543:EXIG RS12030
gene id: 262543:EXIG_RS12030
uniprot id: B1YL09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

262543:EXIG RS02160
gene id: 262543:EXIG_RS02160
uniprot id: B1YII7
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

262543:EXIG RS08525
gene id: 262543:EXIG_RS08525
uniprot id: B1YH51
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS02830
gene id: 262543:EXIG_RS02830
uniprot id: B1YJG9
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

262543:EXIG RS10085
gene id: 262543:EXIG_RS10085
uniprot id: B1YIU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

262543:EXIG RS10695
gene id: 262543:EXIG_RS10695
uniprot id: B1YJQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

262543:EXIG RS06520
gene id: 262543:EXIG_RS06520
uniprot id: B1YEW1
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

262543:EXIG RS10340
gene id: 262543:EXIG_RS10340
uniprot id: B1YJ91
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

262543:EXIG RS05820
gene id: 262543:EXIG_RS05820
uniprot id: B1YE76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0154 family.
messages: Cell membrane

262543:EXIG RS02020
gene id: 262543:EXIG_RS02020
uniprot id: B1YIF9
names: Similarity
messages: Belongs to the peptidase S8 family.

262543:EXIG RS13370
gene id: 262543:EXIG_RS13370
uniprot id: B1YML9
names: Similarity
messages: Belongs to the CDP-glycerol glycerophosphotransferase family.

262543:EXIG RS04575
gene id: 262543:EXIG_RS04575
uniprot id: B1YL98
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

262543:EXIG RS10310
gene id: 262543:EXIG_RS10310
uniprot id: B1YJ85
names: Function
names: Similarity
names: Subunit
messages: A non-essential component of RNA polymerase (RNAP).
messages: Belongs to the RNA polymerase subunit epsilon family.
messages: RNAP is composed of a core of 2 alpha, a beta and a beta' subunit. The core is associated with a delta subunit, and at least one of epsilon or omega. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

262543:EXIG RS06925
gene id: 262543:EXIG_RS06925
uniprot id: B1YFC3
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

262543:EXIG RS10435
gene id: 262543:EXIG_RS10435
uniprot id: B1YJB0
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS10440
gene id: 262543:EXIG_RS10440
uniprot id: B1YJB1
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

262543:EXIG RS10270
gene id: 262543:EXIG_RS10270
uniprot id: B1YJ77
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.

262543:EXIG RS05740
gene id: 262543:EXIG_RS05740
uniprot id: B1YMH6
names: Similarity
messages: Belongs to the glutamine synthetase family.

262543:EXIG RS13555
gene id: 262543:EXIG_RS13555
uniprot id: B1YMQ6
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

262543:EXIG RS13805
gene id: 262543:EXIG_RS13805
uniprot id: B1YEJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

262543:EXIG RS13670
gene id: 262543:EXIG_RS13670
uniprot id: B1YEH1
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS00280
gene id: 262543:EXIG_RS00280
uniprot id: B1YGE2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

262543:EXIG RS11760
gene id: 262543:EXIG_RS11760
uniprot id: B1YKV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

262543:EXIG RS13785
gene id: 262543:EXIG_RS13785
uniprot id: B1YEJ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: Homodimer.
messages: In the N-terminal section; belongs to the DHBP synthase family.

262543:EXIG RS09420
gene id: 262543:EXIG_RS09420
uniprot id: B1YI59
names: Similarity
messages: Belongs to the ribF family.

262543:EXIG RS12355
gene id: 262543:EXIG_RS12355
uniprot id: B1YLH0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

262543:EXIG RS15310
gene id: 262543:EXIG_RS15310
uniprot id: B1YG71
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

262543:EXIG RS03800
gene id: 262543:EXIG_RS03800
uniprot id: B1YKJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

262543:EXIG RS00380
gene id: 262543:EXIG_RS00380
uniprot id: B1YGQ4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

262543:EXIG RS08600
gene id: 262543:EXIG_RS08600
uniprot id: B1YH65
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

262543:EXIG RS04490
gene id: 262543:EXIG_RS04490
uniprot id: B1YL81
names: PTM
messages: Binds 1 heme c group covalently per subunit.

262543:EXIG RS09565
gene id: 262543:EXIG_RS09565
uniprot id: B1YI88
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

262543:EXIG RS06465
gene id: 262543:EXIG_RS06465
uniprot id: B1YEV2
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

262543:EXIG RS10745
gene id: 262543:EXIG_RS10745
uniprot id: B1YJR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0053 family.
messages: Membrane

262543:EXIG RS11475
gene id: 262543:EXIG_RS11475
uniprot id: B1YKE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

262543:EXIG RS09625
gene id: 262543:EXIG_RS09625
uniprot id: B1YIA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS04140
gene id: 262543:EXIG_RS04140
uniprot id: B1YKR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArsB family.
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS14685
gene id: 262543:EXIG_RS14685
uniprot id: B1YFK4
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

262543:EXIG RS00835
gene id: 262543:EXIG_RS00835
uniprot id: B1YH84
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

262543:EXIG RS04350
gene id: 262543:EXIG_RS04350
uniprot id: B1YL54
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

262543:EXIG RS02625
gene id: 262543:EXIG_RS02625
uniprot id: B1YJ29
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

262543:EXIG RS03795
gene id: 262543:EXIG_RS03795
uniprot id: B1YKJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

262543:EXIG RS05415
gene id: 262543:EXIG_RS05415
uniprot id: B1YMB1
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

262543:EXIG RS00780
gene id: 262543:EXIG_RS00780
uniprot id: B1YGX2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

262543:EXIG RS01205
gene id: 262543:EXIG_RS01205
uniprot id: B1YHE5
names: Similarity
messages: Belongs to the CDP-glycerol glycerophosphotransferase family.

262543:EXIG RS00325
gene id: 262543:EXIG_RS00325
uniprot id: B1YGP5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

262543:EXIG RS01485
gene id: 262543:EXIG_RS01485
uniprot id: B1YHV1
names: Similarity
messages: Belongs to the nitroreductase family.

262543:EXIG RS01195
gene id: 262543:EXIG_RS01195
uniprot id: B1YHE3
names: Caution
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. TarI subfamily.
messages: Catalyzes the transfer of the cytidylyl group of CTP to D-ribitol 5-phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

262543:EXIG RS08730
gene id: 262543:EXIG_RS08730
uniprot id: B1YHH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit C family.
messages: Membrane

262543:EXIG RS15645
gene id: 262543:EXIG_RS15645
uniprot id: B1YG23
names: Similarity
messages: Belongs to the Nudix hydrolase family.

262543:EXIG RS03675
gene id: 262543:EXIG_RS03675
uniprot id: B1YK69
names: Similarity
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

262543:EXIG RS10680
gene id: 262543:EXIG_RS10680
uniprot id: B1YJG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

262543:EXIG RS11145
gene id: 262543:EXIG_RS11145
uniprot id: B1YJZ7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

262543:EXIG RS01295
gene id: 262543:EXIG_RS01295
uniprot id: B1YHG4
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS09285
gene id: 262543:EXIG_RS09285
uniprot id: B1YI33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

262543:EXIG RS14160
gene id: 262543:EXIG_RS14160
uniprot id: B1YF13
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS14540
gene id: 262543:EXIG_RS14540
uniprot id: B1YF76
names: Similarity
messages: Belongs to the UPF0234 family.

262543:EXIG RS15220
gene id: 262543:EXIG_RS15220
uniprot id: B1YG54
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS12935
gene id: 262543:EXIG_RS12935
uniprot id: B1YM32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS08870
gene id: 262543:EXIG_RS08870
uniprot id: B1YHK3
names: Similarity
messages: Belongs to the glutamate synthase family.

262543:EXIG RS03945
gene id: 262543:EXIG_RS03945
uniprot id: B1YKM2
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS03415
gene id: 262543:EXIG_RS03415
uniprot id: B1YK34
names: Similarity
messages: Belongs to the EamA transporter family.

262543:EXIG RS02200
gene id: 262543:EXIG_RS02200
uniprot id: B1YIJ5
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

262543:EXIG RS08660
gene id: 262543:EXIG_RS08660
uniprot id: B1YH76
names: Subcellular Location Annotation
messages: Cytoplasm

262543:EXIG RS07745
gene id: 262543:EXIG_RS07745
uniprot id: B1YGF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0014 family.
messages: Membrane

262543:EXIG RS04730
gene id: 262543:EXIG_RS04730
uniprot id: B1YLC7
names: Similarity
messages: Belongs to the ArsC family.

262543:EXIG RS10605
gene id: 262543:EXIG_RS10605
uniprot id: B1YJE5
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

262543:EXIG RS11755
gene id: 262543:EXIG_RS11755
uniprot id: B1YKV4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

262543:EXIG RS00630
gene id: 262543:EXIG_RS00630
uniprot id: B1YGU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

262543:EXIG RS04435
gene id: 262543:EXIG_RS04435
uniprot id: B1YL70
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

262543:EXIG RS12915
gene id: 262543:EXIG_RS12915
uniprot id: B1YM29
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

262543:EXIG RS02945
gene id: 262543:EXIG_RS02945
uniprot id: B1YJJ1
names: Similarity
messages: Belongs to the ThiD family.

262543:EXIG RS14895
gene id: 262543:EXIG_RS14895
uniprot id: B1YFP7
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS09680
gene id: 262543:EXIG_RS09680
uniprot id: B1YIB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

262543:EXIG RS09180
gene id: 262543:EXIG_RS09180
uniprot id: B1YHR6
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS10535
gene id: 262543:EXIG_RS10535
uniprot id: B1YJD1
names: Function
names: Similarity
messages: Belongs to the transposase IS30 family.
messages: Required for the transposition of the insertion element.

262543:EXIG RS08295
gene id: 262543:EXIG_RS08295
uniprot id: B1YH04
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the DyP-type peroxidase family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.
messages: Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact.

262543:EXIG RS00335
gene id: 262543:EXIG_RS00335
uniprot id: B1YGP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

262543:EXIG RS10155
gene id: 262543:EXIG_RS10155
uniprot id: B1YIV8
names: Similarity
messages: Belongs to the SCO1/2 family.

262543:EXIG RS05625
gene id: 262543:EXIG_RS05625
uniprot id: B1YMF3
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

262543:EXIG RS04865
gene id: 262543:EXIG_RS04865
uniprot id: B1YLQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

262543:EXIG RS12205
gene id: 262543:EXIG_RS12205
uniprot id: B1YLE1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.

262543:EXIG RS00725
gene id: 262543:EXIG_RS00725
uniprot id: B1YGW1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

262543:EXIG RS10570
gene id: 262543:EXIG_RS10570
uniprot id: B1YJD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

262543:EXIG RS11765
gene id: 262543:EXIG_RS11765
uniprot id: B1YKV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. EmrB family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS04740
gene id: 262543:EXIG_RS04740
uniprot id: B1YLC9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

262543:EXIG RS10070
gene id: 262543:EXIG_RS10070
uniprot id: B1YIU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

262543:EXIG RS09350
gene id: 262543:EXIG_RS09350
uniprot id: B1YI45
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS00810
gene id: 262543:EXIG_RS00810
uniprot id: B1YGX8
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

262543:EXIG RS09220
gene id: 262543:EXIG_RS09220
uniprot id: B1YI20
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

262543:EXIG RS12845
gene id: 262543:EXIG_RS12845
uniprot id: B1YM15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS06910
gene id: 262543:EXIG_RS06910
uniprot id: B1YFC0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

262543:EXIG RS10040
gene id: 262543:EXIG_RS10040
uniprot id: B1YIT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

262543:EXIG RS01780
gene id: 262543:EXIG_RS01780
uniprot id: B1YI10
names: Similarity
messages: Belongs to the RutC family.

262543:EXIG RS09465
gene id: 262543:EXIG_RS09465
uniprot id: B1YI68
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
messages: Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.
messages: Cytoplasm
messages: Homodimer.

262543:EXIG RS14930
gene id: 262543:EXIG_RS14930
uniprot id: B1YFQ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

262543:EXIG RS09410
gene id: 262543:EXIG_RS09410
uniprot id: B1YI57
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

262543:EXIG RS14065
gene id: 262543:EXIG_RS14065
uniprot id: B1YEQ1
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the ferredoxin--NADP reductase type 2 family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

262543:EXIG RS07475
gene id: 262543:EXIG_RS07475
uniprot id: B1YFX5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. TCR/Tet family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS12080
gene id: 262543:EXIG_RS12080
uniprot id: B1YL19
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

262543:EXIG RS09210
gene id: 262543:EXIG_RS09210
uniprot id: B1YI18
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

262543:EXIG RS05275
gene id: 262543:EXIG_RS05275
uniprot id: B1YM83
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS10710
gene id: 262543:EXIG_RS10710
uniprot id: B1YJR1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

262543:EXIG RS09900
gene id: 262543:EXIG_RS09900
uniprot id: B1YIQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

262543:EXIG RS11260
gene id: 262543:EXIG_RS11260
uniprot id: B1YKA5
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

262543:EXIG RS10325
gene id: 262543:EXIG_RS10325
uniprot id: B1YJ88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome ubiquinol oxidase subunit 2 family.
messages: Membrane

262543:EXIG RS05865
gene id: 262543:EXIG_RS05865
uniprot id: B1YE85
names: Similarity
messages: Belongs to the peptidase S66 family.

262543:EXIG RS05155
gene id: 262543:EXIG_RS05155
uniprot id: B1YLW2
names: Subcellular Location Annotation
messages: Cell membrane

262543:EXIG RS08300
gene id: 262543:EXIG_RS08300
uniprot id: B1YH05
names: Similarity
messages: Belongs to the EfeM/EfeO family.

262543:EXIG RS06515
gene id: 262543:EXIG_RS06515
uniprot id: B1YEW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase D family. Cardiolipin synthase subfamily.
messages: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.
messages: Cell membrane
messages: Membrane

262543:EXIG RS03855
gene id: 262543:EXIG_RS03855
uniprot id: B1YKK3
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

262543:EXIG RS14660
gene id: 262543:EXIG_RS14660
uniprot id: B1YFJ9
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS04250
gene id: 262543:EXIG_RS04250
uniprot id: B1YKT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

262543:EXIG RS09835
gene id: 262543:EXIG_RS09835
uniprot id: B1YIP4
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS13650
gene id: 262543:EXIG_RS13650
uniprot id: B1YEG7
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

262543:EXIG RS11300
gene id: 262543:EXIG_RS11300
uniprot id: B1YKB3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

262543:EXIG RS02730
gene id: 262543:EXIG_RS02730
uniprot id: B1YJ50
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

262543:EXIG RS14780
gene id: 262543:EXIG_RS14780
uniprot id: B1YFM3
names: Similarity
messages: Belongs to the ThiD family.

262543:EXIG RS07840
gene id: 262543:EXIG_RS07840
uniprot id: B1YGH0
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS04085
gene id: 262543:EXIG_RS04085
uniprot id: B1YKQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS08520
gene id: 262543:EXIG_RS08520
uniprot id: B1YH50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS00805
gene id: 262543:EXIG_RS00805
uniprot id: B1YGX7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

262543:EXIG RS00235
gene id: 262543:EXIG_RS00235
uniprot id: B1YGD3
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

262543:EXIG RS09870
gene id: 262543:EXIG_RS09870
uniprot id: B1YIQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: Cytoplasm
messages: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.

262543:EXIG RS12335
gene id: 262543:EXIG_RS12335
uniprot id: B1YLG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division.

262543:EXIG RS03375
gene id: 262543:EXIG_RS03375
uniprot id: B1YK26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MenH family.
messages: Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).
messages: Monomer.

262543:EXIG RS05445
gene id: 262543:EXIG_RS05445
uniprot id: B1YMB7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane
messages: This protein catalyzes the committed step to the synthesis of the acidic phospholipids.

262543:EXIG RS00530
gene id: 262543:EXIG_RS00530
uniprot id: B1YGS2
names: Similarity
messages: Belongs to the ClpA/ClpB family.

262543:EXIG RS02220
gene id: 262543:EXIG_RS02220
uniprot id: B1YIJ9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

262543:EXIG RS05125
gene id: 262543:EXIG_RS05125
uniprot id: B1YLV6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

262543:EXIG RS09800
gene id: 262543:EXIG_RS09800
uniprot id: B1YIN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

262543:EXIG RS10825
gene id: 262543:EXIG_RS10825
uniprot id: B1YJT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Membrane

262543:EXIG RS13800
gene id: 262543:EXIG_RS13800
uniprot id: B1YEJ7
names: Similarity
messages: Belongs to the peptidase M20A family.

262543:EXIG RS02330
gene id: 262543:EXIG_RS02330
uniprot id: B1YIX3
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS10760
gene id: 262543:EXIG_RS10760
uniprot id: B1YJS1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

262543:EXIG RS02505
gene id: 262543:EXIG_RS02505
uniprot id: B1YJ05
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

262543:EXIG RS03975
gene id: 262543:EXIG_RS03975
uniprot id: B1YKM8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. AddA subfamily.
messages: Heterodimer of AddA and AddB/RexB.
messages: The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.

262543:EXIG RS07495
gene id: 262543:EXIG_RS07495
uniprot id: B1YFX8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

262543:EXIG RS10575
gene id: 262543:EXIG_RS10575
uniprot id: B1YJD9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.
messages: Catalyzes the methylation of 5-hydroxyuridine (ho5U) to form 5-methoxyuridine (mo5U) at position 34 in tRNAs.
messages: Homodimer.

262543:EXIG RS15035
gene id: 262543:EXIG_RS15035
uniprot id: B1YFS5
names: Similarity
messages: Belongs to the Nudix hydrolase family.

262543:EXIG RS05685
gene id: 262543:EXIG_RS05685
uniprot id: B1YMG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1C family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS03895
gene id: 262543:EXIG_RS03895
uniprot id: B1YKL1
names: Function
messages: Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA.

262543:EXIG RS09785
gene id: 262543:EXIG_RS09785
uniprot id: B1YIN3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

262543:EXIG RS11010
gene id: 262543:EXIG_RS11010
uniprot id: B1YJX0
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

262543:EXIG RS10195
gene id: 262543:EXIG_RS10195
uniprot id: B1YIW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COX15/CtaA family. Type 1 subfamily.
messages: Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
messages: Cell membrane
messages: Interacts with CtaB.

262543:EXIG RS04285
gene id: 262543:EXIG_RS04285
uniprot id: B1YL40
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

262543:EXIG RS12045
gene id: 262543:EXIG_RS12045
uniprot id: B1YL12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

262543:EXIG RS10120
gene id: 262543:EXIG_RS10120
uniprot id: B1YIV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

262543:EXIG RS11195
gene id: 262543:EXIG_RS11195
uniprot id: B1YK92
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

262543:EXIG RS01185
gene id: 262543:EXIG_RS01185
uniprot id: B1YHE1
names: Similarity
messages: Belongs to the acyltransferase 3 family.

262543:EXIG RS04505
gene id: 262543:EXIG_RS04505
uniprot id: B1YL84
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

262543:EXIG RS13845
gene id: 262543:EXIG_RS13845
uniprot id: B1YEK7
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

262543:EXIG RS11460
gene id: 262543:EXIG_RS11460
uniprot id: B1YKE5
names: Similarity
messages: Belongs to the peptidase M29 family.

262543:EXIG RS00645
gene id: 262543:EXIG_RS00645
uniprot id: B1YGU5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

262543:EXIG RS04860
gene id: 262543:EXIG_RS04860
uniprot id: B1YLQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

262543:EXIG RS14600
gene id: 262543:EXIG_RS14600
uniprot id: B1YFI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

262543:EXIG RS06090
gene id: 262543:EXIG_RS06090
uniprot id: B1YED2
names: Similarity
messages: Belongs to the UPF0178 family.

262543:EXIG RS13455
gene id: 262543:EXIG_RS13455
uniprot id: B1YMN6
names: Similarity
messages: Belongs to the glycosyl hydrolase 70 family.

262543:EXIG RS05135
gene id: 262543:EXIG_RS05135
uniprot id: B1YLV8
names: Similarity
messages: Belongs to the type IA topoisomerase family.

262543:EXIG RS01890
gene id: 262543:EXIG_RS01890
uniprot id: B1YID3
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS06215
gene id: 262543:EXIG_RS06215
uniprot id: B1YEF8
names: Cofactor
names: Similarity
messages: Belongs to the iron-containing alcohol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.

262543:EXIG RS04975
gene id: 262543:EXIG_RS04975
uniprot id: B1YLS5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

262543:EXIG RS04955
gene id: 262543:EXIG_RS04955
uniprot id: B1YLS1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

262543:EXIG RS02490
gene id: 262543:EXIG_RS02490
uniprot id: B1YJ02
names: Similarity
messages: Belongs to the SAICAR synthetase family.

262543:EXIG RS00740
gene id: 262543:EXIG_RS00740
uniprot id: B1YGW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

262543:EXIG RS05450
gene id: 262543:EXIG_RS05450
uniprot id: B1YMB8
names: Similarity
messages: Belongs to the CinA family.

262543:EXIG RS03370
gene id: 262543:EXIG_RS03370
uniprot id: B1YK25
names: Caution
names: Function
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
messages: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

262543:EXIG RS03790
gene id: 262543:EXIG_RS03790
uniprot id: B1YKJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

262543:EXIG RS05920
gene id: 262543:EXIG_RS05920
uniprot id: B1YE96
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

262543:EXIG RS11670
gene id: 262543:EXIG_RS11670
uniprot id: B1YKI6
names: Similarity
messages: Belongs to the Nudix hydrolase family.

262543:EXIG RS02340
gene id: 262543:EXIG_RS02340
uniprot id: B1YIX5
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

262543:EXIG RS11395
gene id: 262543:EXIG_RS11395
uniprot id: B1YKD2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

262543:EXIG RS14775
gene id: 262543:EXIG_RS14775
uniprot id: B1YFM2
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS03385
gene id: 262543:EXIG_RS03385
uniprot id: B1YK28
names: Similarity
messages: Belongs to the isochorismate synthase family.

262543:EXIG RS09540
gene id: 262543:EXIG_RS09540
uniprot id: B1YI83
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

262543:EXIG RS07970
gene id: 262543:EXIG_RS07970
uniprot id: B1YGJ5
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

262543:EXIG RS02295
gene id: 262543:EXIG_RS02295
uniprot id: B1YIL3
names: Cofactor
messages: Binds 1 zinc ion per subunit.

262543:EXIG RS15410
gene id: 262543:EXIG_RS15410
uniprot id: B1YG93
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

262543:EXIG RS10060
gene id: 262543:EXIG_RS10060
uniprot id: B1YIT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

262543:EXIG RS02680
gene id: 262543:EXIG_RS02680
uniprot id: B1YJ40
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

262543:EXIG RS00700
gene id: 262543:EXIG_RS00700
uniprot id: B1YGV6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

262543:EXIG RS11405
gene id: 262543:EXIG_RS11405
uniprot id: B1YKD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

262543:EXIG RS00785
gene id: 262543:EXIG_RS00785
uniprot id: B1YGX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

262543:EXIG RS02315
gene id: 262543:EXIG_RS02315
uniprot id: B1YIX0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

262543:EXIG RS12185
gene id: 262543:EXIG_RS12185
uniprot id: B1YLD7
names: Similarity
messages: Belongs to the fatty acid desaturase type 2 family.

262543:EXIG RS08920
gene id: 262543:EXIG_RS08920
uniprot id: B1YHL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Catalyzes the sodium-dependent uptake of extracellular L-proline.
messages: Cell membrane
messages: Membrane

262543:EXIG RS11295
gene id: 262543:EXIG_RS11295
uniprot id: B1YKB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

262543:EXIG RS12780
gene id: 262543:EXIG_RS12780
uniprot id: B1YM02
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

262543:EXIG RS08180
gene id: 262543:EXIG_RS08180
uniprot id: B1YGY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

262543:EXIG RS14135
gene id: 262543:EXIG_RS14135
uniprot id: B1YF08
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

262543:EXIG RS01540
gene id: 262543:EXIG_RS01540
uniprot id: B1YHW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. EmrB family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS00795
gene id: 262543:EXIG_RS00795
uniprot id: B1YGX5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

262543:EXIG RS06825
gene id: 262543:EXIG_RS06825
uniprot id: B1YFA1
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

262543:EXIG RS12360
gene id: 262543:EXIG_RS12360
uniprot id: B1YLH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

262543:EXIG RS05030
gene id: 262543:EXIG_RS05030
uniprot id: B1YLT6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

262543:EXIG RS10980
gene id: 262543:EXIG_RS10980
uniprot id: B1YJW4
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

262543:EXIG RS05580
gene id: 262543:EXIG_RS05580
uniprot id: B1YME4
names: Function
names: Similarity
messages: Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
messages: Belongs to the organic radical-activating enzymes family.

262543:EXIG RS13855
gene id: 262543:EXIG_RS13855
uniprot id: B1YEK9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

262543:EXIG RS05280
gene id: 262543:EXIG_RS05280
uniprot id: B1YM84
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS11925
gene id: 262543:EXIG_RS11925
uniprot id: B1YKY7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

262543:EXIG RS03460
gene id: 262543:EXIG_RS03460
uniprot id: B1YK43
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS09815
gene id: 262543:EXIG_RS09815
uniprot id: B1YIN9
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

262543:EXIG RS14695
gene id: 262543:EXIG_RS14695
uniprot id: B1YFK6
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS03145
gene id: 262543:EXIG_RS03145
uniprot id: B1YJN0
names: Similarity
messages: Belongs to the formate--tetrahydrofolate ligase family.

262543:EXIG RS01430
gene id: 262543:EXIG_RS01430
uniprot id: B1YHU0
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the octanoyltransferase LipL family.
messages: Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes.
messages: The reaction proceeds via a thioester-linked acyl-enzyme intermediate.

262543:EXIG RS04885
gene id: 262543:EXIG_RS04885
uniprot id: B1YLQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

262543:EXIG RS11590
gene id: 262543:EXIG_RS11590
uniprot id: B1YKH1
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS12575
gene id: 262543:EXIG_RS12575
uniprot id: B1YLL4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system DegS/DegU, which plays an important role in the transition growth phase.

262543:EXIG RS08505
gene id: 262543:EXIG_RS08505
uniprot id: B1YH47
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

262543:EXIG RS11060
gene id: 262543:EXIG_RS11060
uniprot id: B1YJY0
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

262543:EXIG RS09120
gene id: 262543:EXIG_RS09120
uniprot id: B1YHQ3
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

262543:EXIG RS15180
gene id: 262543:EXIG_RS15180
uniprot id: B1YG46
names: Similarity
messages: Belongs to the peptidase M20A family.

262543:EXIG RS09150
gene id: 262543:EXIG_RS09150
uniprot id: B1YHR0
names: Caution
names: Function
names: Similarity
messages: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.
messages: Belongs to the biotin--protein ligase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

262543:EXIG RS02480
gene id: 262543:EXIG_RS02480
uniprot id: B1YJ00
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.

262543:EXIG RS13005
gene id: 262543:EXIG_RS13005
uniprot id: B1YM47
names: Similarity
messages: Belongs to the glycerate kinase type-1 family.

262543:EXIG RS12850
gene id: 262543:EXIG_RS12850
uniprot id: B1YM16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS12940
gene id: 262543:EXIG_RS12940
uniprot id: B1YM33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

262543:EXIG RS09790
gene id: 262543:EXIG_RS09790
uniprot id: B1YIN4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

262543:EXIG RS09905
gene id: 262543:EXIG_RS09905
uniprot id: B1YIQ7
names: Function
names: Similarity
names: Subunit
messages: Associates with stalled 50S ribosomal subunits.
messages: Belongs to the NEMF family.
messages: Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.

262543:EXIG RS09590
gene id: 262543:EXIG_RS09590
uniprot id: B1YI93
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Membrane

262543:EXIG RS15230
gene id: 262543:EXIG_RS15230
uniprot id: B1YG56
names: Function
names: Similarity
messages: Belongs to the ketopantoate reductase family.
messages: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

262543:EXIG RS10860
gene id: 262543:EXIG_RS10860
uniprot id: B1YJU1
names: Function
messages: Required for transformation and DNA binding.

262543:EXIG RS03080
gene id: 262543:EXIG_RS03080
uniprot id: B1YJL7
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS13690
gene id: 262543:EXIG_RS13690
uniprot id: B1YEH5
names: Similarity
messages: Belongs to the LacAB/RpiB family.

262543:EXIG RS13110
gene id: 262543:EXIG_RS13110
uniprot id: B1YM67
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS04105
gene id: 262543:EXIG_RS04105
uniprot id: B1YKQ3
names: Similarity
messages: Belongs to the glycosyl hydrolase 65 family.

262543:EXIG RS04790
gene id: 262543:EXIG_RS04790
uniprot id: B1YLN8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family. C-terminal subunit subfamily.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.

262543:EXIG RS13060
gene id: 262543:EXIG_RS13060
uniprot id: B1YM57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FemABX family.
messages: Cytoplasm

262543:EXIG RS10215
gene id: 262543:EXIG_RS10215
uniprot id: B1YJ65
names: Similarity
messages: Belongs to the UPF0358 family.

262543:EXIG RS04840
gene id: 262543:EXIG_RS04840
uniprot id: B1YLP8
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

262543:EXIG RS11845
gene id: 262543:EXIG_RS11845
uniprot id: B1YKX2
names: Cofactor
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. NagD family.
messages: Divalent metal ions. Mg(2+) is the most effective.

262543:EXIG RS02115
gene id: 262543:EXIG_RS02115
uniprot id: B1YIH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. GalK subfamily.
messages: Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
messages: Cytoplasm

262543:EXIG RS09165
gene id: 262543:EXIG_RS09165
uniprot id: B1YHR3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

262543:EXIG RS13480
gene id: 262543:EXIG_RS13480
uniprot id: B1YMP1
names: Similarity
messages: Belongs to the pirin family.

262543:EXIG RS10210
gene id: 262543:EXIG_RS10210
uniprot id: B1YJ64
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS00985
gene id: 262543:EXIG_RS00985
uniprot id: B1YHA2
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

262543:EXIG RS05325
gene id: 262543:EXIG_RS05325
uniprot id: B1YM93
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

262543:EXIG RS09950
gene id: 262543:EXIG_RS09950
uniprot id: B1YIR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the OMP decarboxylase family. Type 1 subfamily.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
messages: Homodimer.

262543:EXIG RS12190
gene id: 262543:EXIG_RS12190
uniprot id: B1YLD8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

262543:EXIG RS15420
gene id: 262543:EXIG_RS15420
uniprot id: B1YG95
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

262543:EXIG RS13860
gene id: 262543:EXIG_RS13860
uniprot id: B1YEL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

262543:EXIG RS09585
gene id: 262543:EXIG_RS09585
uniprot id: B1YI92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Membrane

262543:EXIG RS08375
gene id: 262543:EXIG_RS08375
uniprot id: B1YH21
names: Similarity
messages: Belongs to the OsmC/Ohr family.

262543:EXIG RS05460
gene id: 262543:EXIG_RS05460
uniprot id: B1YMC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

262543:EXIG RS12225
gene id: 262543:EXIG_RS12225
uniprot id: B1YLE5
names: Similarity
messages: Belongs to the sigma-54 factor family.

262543:EXIG RS15375
gene id: 262543:EXIG_RS15375
uniprot id: B1YG85
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

262543:EXIG RS14355
gene id: 262543:EXIG_RS14355
uniprot id: B1YF38
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

262543:EXIG RS09920
gene id: 262543:EXIG_RS09920
uniprot id: B1YIR0
names: Similarity
messages: Belongs to the UPF0173 family.

262543:EXIG RS06930
gene id: 262543:EXIG_RS06930
uniprot id: B1YFC4
names: Similarity
messages: Belongs to the DapA family.

262543:EXIG RS12620
gene id: 262543:EXIG_RS12620
uniprot id: B1YLM3
names: Cofactor
messages: Binds 2 magnesium ions per subunit.

262543:EXIG RS14850
gene id: 262543:EXIG_RS14850
uniprot id: B1YFN7
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS11355
gene id: 262543:EXIG_RS11355
uniprot id: B1YKC4
names: Function
names: Similarity
messages: Belongs to the transposase IS30 family.
messages: Required for the transposition of the insertion element.

262543:EXIG RS08705
gene id: 262543:EXIG_RS08705
uniprot id: B1YHH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family. YeeN subfamily.
messages: Cytoplasm

262543:EXIG RS01690
gene id: 262543:EXIG_RS01690
uniprot id: B1YHZ2
names: Similarity
messages: Belongs to the acyltransferase 3 family.

262543:EXIG RS14795
gene id: 262543:EXIG_RS14795
uniprot id: B1YFM6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
messages: Homodimer.

262543:EXIG RS12765
gene id: 262543:EXIG_RS12765
uniprot id: B1YLZ9
names: Similarity
messages: Belongs to the diacylglycerol/lipid kinase family.

262543:EXIG RS15280
gene id: 262543:EXIG_RS15280
uniprot id: B1YG65
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS00410
gene id: 262543:EXIG_RS00410
uniprot id: B1YGR0
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

262543:EXIG RS04155
gene id: 262543:EXIG_RS04155
uniprot id: B1YKR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).

262543:EXIG RS02125
gene id: 262543:EXIG_RS02125
uniprot id: B1YII0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.
messages: Cytoplasm

262543:EXIG RS11540
gene id: 262543:EXIG_RS11540
uniprot id: B1YKG1
names: Similarity
messages: Belongs to the alpha-acetolactate decarboxylase family.

262543:EXIG RS14200
gene id: 262543:EXIG_RS14200
uniprot id: B1YF21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein bS18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm

262543:EXIG RS13935
gene id: 262543:EXIG_RS13935
uniprot id: B1YEM5
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS12035
gene id: 262543:EXIG_RS12035
uniprot id: B1YL10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

262543:EXIG RS05610
gene id: 262543:EXIG_RS05610
uniprot id: B1YMF0
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
messages: Belongs to the carbohydrate kinase pfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.

262543:EXIG RS10295
gene id: 262543:EXIG_RS10295
uniprot id: B1YJ82
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

262543:EXIG RS05670
gene id: 262543:EXIG_RS05670
uniprot id: B1YMG2
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS00710
gene id: 262543:EXIG_RS00710
uniprot id: B1YGV8
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

262543:EXIG RS03850
gene id: 262543:EXIG_RS03850
uniprot id: B1YKK2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.

262543:EXIG RS10545
gene id: 262543:EXIG_RS10545
uniprot id: B1YE98
names: Function
names: Similarity
messages: Belongs to the transposase IS30 family.
messages: Required for the transposition of the insertion element.

262543:EXIG RS01480
gene id: 262543:EXIG_RS01480
uniprot id: B1YHV0
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS05550
gene id: 262543:EXIG_RS05550
uniprot id: B1YMD8
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

262543:EXIG RS01965
gene id: 262543:EXIG_RS01965
uniprot id: B1YIE8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

262543:EXIG RS12135
gene id: 262543:EXIG_RS12135
uniprot id: B1YL30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Membrane

262543:EXIG RS14040
gene id: 262543:EXIG_RS14040
uniprot id: B1YEP6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

262543:EXIG RS10465
gene id: 262543:EXIG_RS10465
uniprot id: B1YJB6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

262543:EXIG RS04400
gene id: 262543:EXIG_RS04400
uniprot id: B1YL63
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

262543:EXIG RS09495
gene id: 262543:EXIG_RS09495
uniprot id: B1YI74
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by GTP. Inhibited by UTP.
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

262543:EXIG RS01755
gene id: 262543:EXIG_RS01755
uniprot id: B1YI05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS02325
gene id: 262543:EXIG_RS02325
uniprot id: B1YIX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

262543:EXIG RS04050
gene id: 262543:EXIG_RS04050
uniprot id: B1YKP3
names: Similarity
messages: Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.

262543:EXIG RS00925
gene id: 262543:EXIG_RS00925
uniprot id: B1YH90
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

262543:EXIG RS04080
gene id: 262543:EXIG_RS04080
uniprot id: B1YKP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS10445
gene id: 262543:EXIG_RS10445
uniprot id: B1YJB2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

262543:EXIG RS05615
gene id: 262543:EXIG_RS05615
uniprot id: B1YMF1
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

262543:EXIG RS07870
gene id: 262543:EXIG_RS07870
uniprot id: B1YGH5
names: Subcellular Location Annotation
messages: Cell membrane

262543:EXIG RS13435
gene id: 262543:EXIG_RS13435
uniprot id: B1YMN2
names: Similarity
messages: Belongs to the peptidase S8 family.

262543:EXIG RS02865
gene id: 262543:EXIG_RS02865
uniprot id: B1YJH4
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

262543:EXIG RS11880
gene id: 262543:EXIG_RS11880
uniprot id: B1YKX9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

262543:EXIG RS15130
gene id: 262543:EXIG_RS15130
uniprot id: B1YG36
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

262543:EXIG RS10595
gene id: 262543:EXIG_RS10595
uniprot id: B1YJE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

262543:EXIG RS03515
gene id: 262543:EXIG_RS03515
uniprot id: B1YK54
names: Cofactor
names: Function
names: Similarity
messages: Adenine glycosylase active on G-A mispairs.
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.

262543:EXIG RS08735
gene id: 262543:EXIG_RS08735
uniprot id: B1YHH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family.
messages: Membrane

262543:EXIG RS00775
gene id: 262543:EXIG_RS00775
uniprot id: B1YGX1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

262543:EXIG RS00760
gene id: 262543:EXIG_RS00760
uniprot id: B1YGW8
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

262543:EXIG RS12305
gene id: 262543:EXIG_RS12305
uniprot id: B1YLG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

262543:EXIG RS06880
gene id: 262543:EXIG_RS06880
uniprot id: B1YFB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TerC family.
messages: Membrane

262543:EXIG RS04835
gene id: 262543:EXIG_RS04835
uniprot id: B1YLP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

262543:EXIG RS04315
gene id: 262543:EXIG_RS04315
uniprot id: B1YL46
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS04245
gene id: 262543:EXIG_RS04245
uniprot id: B1YKT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

262543:EXIG RS04415
gene id: 262543:EXIG_RS04415
uniprot id: B1YL66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the flotillin-like FloA family.
messages: Cell membrane
messages: Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts. FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.
messages: Homooligomerizes.
messages: Membrane raft

262543:EXIG RS10725
gene id: 262543:EXIG_RS10725
uniprot id: B1YJR4
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

262543:EXIG RS09805
gene id: 262543:EXIG_RS09805
uniprot id: B1YIN7
names: Function
names: Similarity
messages: Belongs to the FapR family.
messages: Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism.

262543:EXIG RS03380
gene id: 262543:EXIG_RS03380
uniprot id: B1YK27
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TPP enzyme family. MenD subfamily.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
messages: Homodimer.

262543:EXIG RS08170
gene id: 262543:EXIG_RS08170
uniprot id: B1YGN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane

262543:EXIG RS12925
gene id: 262543:EXIG_RS12925
uniprot id: B1YM30
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

262543:EXIG RS06470
gene id: 262543:EXIG_RS06470
uniprot id: B1YEV3
names: Similarity
messages: In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
messages: In the N-terminal section; belongs to the aldehyde dehydrogenase family.

262543:EXIG RS15025
gene id: 262543:EXIG_RS15025
uniprot id: B1YFS3
names: Similarity
messages: Belongs to the OsmC/Ohr family.

262543:EXIG RS04215
gene id: 262543:EXIG_RS04215
uniprot id: B1YKS5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

262543:EXIG RS00830
gene id: 262543:EXIG_RS00830
uniprot id: B1YH83
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.

262543:EXIG RS13400
gene id: 262543:EXIG_RS13400
uniprot id: B1YMM5
names: Similarity
messages: Belongs to the CpsD/CapB family.

262543:EXIG RS15165
gene id: 262543:EXIG_RS15165
uniprot id: B1YG43
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Molecular chaperone. Has ATPase activity.

262543:EXIG RS05010
gene id: 262543:EXIG_RS05010
uniprot id: B1YLT2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TenA family.
messages: Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway.
messages: Homotetramer.

262543:EXIG RS00395
gene id: 262543:EXIG_RS00395
uniprot id: B1YGQ7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

262543:EXIG RS13750
gene id: 262543:EXIG_RS13750
uniprot id: B1YEI7
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

262543:EXIG RS03655
gene id: 262543:EXIG_RS03655
uniprot id: B1YK64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm

262543:EXIG RS15320
gene id: 262543:EXIG_RS15320
uniprot id: B1YG73
names: Similarity
messages: Belongs to the glycosyl hydrolase 3 family.

262543:EXIG RS07280
gene id: 262543:EXIG_RS07280
uniprot id: B1YFU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

262543:EXIG RS10995
gene id: 262543:EXIG_RS10995
uniprot id: B1YJW7
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

262543:EXIG RS13395
gene id: 262543:EXIG_RS13395
uniprot id: B1YMM4
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family.

262543:EXIG RS08605
gene id: 262543:EXIG_RS08605
uniprot id: B1YH66
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

262543:EXIG RS03680
gene id: 262543:EXIG_RS03680
uniprot id: B1YK70
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

262543:EXIG RS02370
gene id: 262543:EXIG_RS02370
uniprot id: B1YIY1
names: Function
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. MtnX family.
messages: Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).

262543:EXIG RS11050
gene id: 262543:EXIG_RS11050
uniprot id: B1YJX8
names: Similarity
messages: Belongs to the thioredoxin family.

262543:EXIG RS14505
gene id: 262543:EXIG_RS14505
uniprot id: B1YF68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.
messages: Cell membrane

262543:EXIG RS13665
gene id: 262543:EXIG_RS13665
uniprot id: B1YEH0
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS10430
gene id: 262543:EXIG_RS10430
uniprot id: B1YJA9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

262543:EXIG RS00125
gene id: 262543:EXIG_RS00125
uniprot id: B1YGC9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

262543:EXIG RS11185
gene id: 262543:EXIG_RS11185
uniprot id: B1YK90
names: Similarity
messages: Belongs to the catalase family.

262543:EXIG RS04125
gene id: 262543:EXIG_RS04125
uniprot id: B1YKQ7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M38 family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Carboxylation allows a single lysine to coordinate two zinc ions.
messages: Catalyzes the hydrolytic cleavage of a subset of L-isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation.
messages: Cytoplasm

262543:EXIG RS07375
gene id: 262543:EXIG_RS07375
uniprot id: B1YFV8
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal/bacterial/fungal opsin family.
messages: Contains one covalently linked retinal chromophore.
messages: Membrane

262543:EXIG RS08875
gene id: 262543:EXIG_RS08875
uniprot id: B1YHK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 3 family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS12200
gene id: 262543:EXIG_RS12200
uniprot id: B1YLE0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

262543:EXIG RS00790
gene id: 262543:EXIG_RS00790
uniprot id: B1YGX4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

262543:EXIG RS07595
gene id: 262543:EXIG_RS07595
uniprot id: B1YFZ7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

262543:EXIG RS10170
gene id: 262543:EXIG_RS10170
uniprot id: B1YIW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase bacterial subunit 4 family.
messages: Membrane

262543:EXIG RS08890
gene id: 262543:EXIG_RS08890
uniprot id: B1YHK7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

262543:EXIG RS02750
gene id: 262543:EXIG_RS02750
uniprot id: B1YJ54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.
messages: Membrane

262543:EXIG RS08165
gene id: 262543:EXIG_RS08165
uniprot id: B1YGN4
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS11280
gene id: 262543:EXIG_RS11280
uniprot id: B1YKA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0756 family.
messages: Cell membrane

262543:EXIG RS11855
gene id: 262543:EXIG_RS11855
uniprot id: B1YKX4
names: Similarity
messages: Belongs to the FBPase class 2 family.

262543:EXIG RS06445
gene id: 262543:EXIG_RS06445
uniprot id: B1YEU8
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS05130
gene id: 262543:EXIG_RS05130
uniprot id: B1YLV7
names: Similarity
messages: Belongs to the EamA transporter family.

262543:EXIG RS13380
gene id: 262543:EXIG_RS13380
uniprot id: B1YMM1
names: Similarity
messages: Belongs to the bacterial sugar transferase family.

262543:EXIG RS03410
gene id: 262543:EXIG_RS03410
uniprot id: B1YK33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

262543:EXIG RS11935
gene id: 262543:EXIG_RS11935
uniprot id: B1YKY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS09145
gene id: 262543:EXIG_RS09145
uniprot id: B1YHQ9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

262543:EXIG RS04710
gene id: 262543:EXIG_RS04710
uniprot id: B1YLC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LTA synthase family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS09250
gene id: 262543:EXIG_RS09250
uniprot id: B1YI26
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

262543:EXIG RS06315
gene id: 262543:EXIG_RS06315
uniprot id: B1YES2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

262543:EXIG RS12365
gene id: 262543:EXIG_RS12365
uniprot id: B1YLH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

262543:EXIG RS12195
gene id: 262543:EXIG_RS12195
uniprot id: B1YLD9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

262543:EXIG RS03910
gene id: 262543:EXIG_RS03910
uniprot id: B1YKL4
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

262543:EXIG RS05455
gene id: 262543:EXIG_RS05455
uniprot id: B1YMB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

262543:EXIG RS05245
gene id: 262543:EXIG_RS05245
uniprot id: B1YE98
names: Function
names: Similarity
messages: Belongs to the transposase IS30 family.
messages: Required for the transposition of the insertion element.

262543:EXIG RS09955
gene id: 262543:EXIG_RS09955
uniprot id: B1YIR7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
messages: Cytoplasm
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.

262543:EXIG RS06050
gene id: 262543:EXIG_RS06050
uniprot id: B1YEC4
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

262543:EXIG RS10960
gene id: 262543:EXIG_RS10960
uniprot id: B1YJW1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

262543:EXIG RS08720
gene id: 262543:EXIG_RS08720
uniprot id: B1YHH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS03825
gene id: 262543:EXIG_RS03825
uniprot id: B1YKJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.

262543:EXIG RS07125
gene id: 262543:EXIG_RS07125
uniprot id: B1YFG3
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the phD/YefM antitoxin family.

262543:EXIG RS05350
gene id: 262543:EXIG_RS05350
uniprot id: B1YM98
names: Similarity
messages: Belongs to the peptidase S66 family.

262543:EXIG RS09190
gene id: 262543:EXIG_RS09190
uniprot id: B1YI14
names: Similarity
messages: Belongs to the Rieske iron-sulfur protein family.

262543:EXIG RS14015
gene id: 262543:EXIG_RS14015
uniprot id: B1YEP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LTA synthase family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS02050
gene id: 262543:EXIG_RS02050
uniprot id: B1YIG5
names: Similarity
messages: Belongs to the universal stress protein A family.

262543:EXIG RS10580
gene id: 262543:EXIG_RS10580
uniprot id: B1YJE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

262543:EXIG RS11505
gene id: 262543:EXIG_RS11505
uniprot id: B1YKF4
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS01370
gene id: 262543:EXIG_RS01370
uniprot id: B1YHS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.
messages: Membrane

262543:EXIG RS09755
gene id: 262543:EXIG_RS09755
uniprot id: B1YIM7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

262543:EXIG RS01990
gene id: 262543:EXIG_RS01990
uniprot id: B1YIF3
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

262543:EXIG RS02475
gene id: 262543:EXIG_RS02475
uniprot id: B1YIZ9
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

262543:EXIG RS09005
gene id: 262543:EXIG_RS09005
uniprot id: B1YHN0
names: Similarity
messages: Belongs to the TelA family.

262543:EXIG RS03885
gene id: 262543:EXIG_RS03885
uniprot id: B1YKK9
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS14305
gene id: 262543:EXIG_RS14305
uniprot id: B1YF28
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

262543:EXIG RS06200
gene id: 262543:EXIG_RS06200
uniprot id: B1YEF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

262543:EXIG RS15465
gene id: 262543:EXIG_RS15465
uniprot id: B1YGA4
names: Similarity
messages: Belongs to the ParB family.

262543:EXIG RS12145
gene id: 262543:EXIG_RS12145
uniprot id: B1YL32
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS05500
gene id: 262543:EXIG_RS05500
uniprot id: B1YMC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

262543:EXIG RS12100
gene id: 262543:EXIG_RS12100
uniprot id: B1YL23
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

262543:EXIG RS15565
gene id: 262543:EXIG_RS15565
uniprot id: B1YLD0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ComGC family.
messages: Cell membrane
messages: Homodimer.
messages: Required for transformation and DNA binding.

262543:EXIG RS05965
gene id: 262543:EXIG_RS05965
uniprot id: B1YE98
names: Function
names: Similarity
messages: Belongs to the transposase IS30 family.
messages: Required for the transposition of the insertion element.

262543:EXIG RS12800
gene id: 262543:EXIG_RS12800
uniprot id: B1YM06
names: Similarity
messages: Belongs to the HesB/IscA family.

262543:EXIG RS06290
gene id: 262543:EXIG_RS06290
uniprot id: B1YER7
names: Similarity
messages: Belongs to the OsmC/Ohr family.

262543:EXIG RS03235
gene id: 262543:EXIG_RS03235
uniprot id: B1YJP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

262543:EXIG RS00515
gene id: 262543:EXIG_RS00515
uniprot id: B1YGR9
names: Similarity
messages: Belongs to the CtsR family.

262543:EXIG RS00950
gene id: 262543:EXIG_RS00950
uniprot id: B1YH95
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

262543:EXIG RS03210
gene id: 262543:EXIG_RS03210
uniprot id: B1YJP3
names: Similarity
messages: Belongs to the CDP-glycerol glycerophosphotransferase family.

262543:EXIG RS08725
gene id: 262543:EXIG_RS08725
uniprot id: B1YHH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit B family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS04540
gene id: 262543:EXIG_RS04540
uniprot id: B1YL91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

262543:EXIG RS09670
gene id: 262543:EXIG_RS09670
uniprot id: B1YIA9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
messages: Belongs to the ClpX chaperone family. HslU subfamily.
messages: Cytoplasm

262543:EXIG RS05375
gene id: 262543:EXIG_RS05375
uniprot id: B1YMA3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ScpA family.
messages: Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.
messages: Cytoplasm
messages: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.

262543:EXIG RS13335
gene id: 262543:EXIG_RS13335
uniprot id: B1YML2
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

262543:EXIG RS06665
gene id: 262543:EXIG_RS06665
uniprot id: B1YEY6
names: Similarity
messages: Belongs to the glutathione peroxidase family.

262543:EXIG RS11530
gene id: 262543:EXIG_RS11530
uniprot id: B1YKF9
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.

262543:EXIG RS13185
gene id: 262543:EXIG_RS13185
uniprot id: B1YMI1
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

262543:EXIG RS09675
gene id: 262543:EXIG_RS09675
uniprot id: B1YIB0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

262543:EXIG RS05545
gene id: 262543:EXIG_RS05545
uniprot id: B1YMD7
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

262543:EXIG RS10005
gene id: 262543:EXIG_RS10005
uniprot id: B1YIS7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

262543:EXIG RS06030
gene id: 262543:EXIG_RS06030
uniprot id: B1YEC0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
messages: Monomer.

262543:EXIG RS11210
gene id: 262543:EXIG_RS11210
uniprot id: B1YK95
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

262543:EXIG RS03105
gene id: 262543:EXIG_RS03105
uniprot id: B1YJM3
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

262543:EXIG RS02485
gene id: 262543:EXIG_RS02485
uniprot id: B1YJ01
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

262543:EXIG RS10490
gene id: 262543:EXIG_RS10490
uniprot id: B1YJC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArsC family. Spx subfamily.
messages: Cytoplasm
messages: Global transcriptional regulator that plays a key role in stress response and exerts either positive or negative regulation of genes. Acts by interacting with the C-terminal domain of the alpha subunit of the RNA polymerase (RNAP). This interaction can enhance binding of RNAP to the promoter region of target genes and stimulate their transcription, or block interaction of RNAP with activator.
messages: Interacts with the C-terminal domain of the alpha subunit of the RNAP.

262543:EXIG RS01335
gene id: 262543:EXIG_RS01335
uniprot id: B1YHS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
messages: Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
messages: Cytoplasm
messages: Homodimer.

262543:EXIG RS07080
gene id: 262543:EXIG_RS07080
uniprot id: B1YFF4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

262543:EXIG RS04360
gene id: 262543:EXIG_RS04360
uniprot id: B1YL56
names: Similarity
messages: Belongs to the ABC transporter superfamily.

262543:EXIG RS11230
gene id: 262543:EXIG_RS11230
uniprot id: B1YK99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

262543:EXIG RS10920
gene id: 262543:EXIG_RS10920
uniprot id: B1YJV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

262543:EXIG RS12795
gene id: 262543:EXIG_RS12795
uniprot id: B1YM05
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

262543:EXIG RS11130
gene id: 262543:EXIG_RS11130
uniprot id: B1YJZ4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

262543:EXIG RS09365
gene id: 262543:EXIG_RS09365
uniprot id: B1YI48
names: Similarity
messages: Belongs to the BMP lipoprotein family.

262543:EXIG RS02775
gene id: 262543:EXIG_RS02775
uniprot id: B1YJ59
names: Similarity
messages: Belongs to the EamA transporter family.

262543:EXIG RS11985
gene id: 262543:EXIG_RS11985
uniprot id: B1YL00
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

262543:EXIG RS14810
gene id: 262543:EXIG_RS14810
uniprot id: B1YFM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
messages: Cytoplasm

262543:EXIG RS10675
gene id: 262543:EXIG_RS10675
uniprot id: B1YJG0
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

262543:EXIG RS14120
gene id: 262543:EXIG_RS14120
uniprot id: B1YF06
names: Similarity
messages: Belongs to the peptidase S8 family.

262543:EXIG RS08530
gene id: 262543:EXIG_RS08530
uniprot id: B1YH52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Cell membrane

262543:EXIG RS04925
gene id: 262543:EXIG_RS04925
uniprot id: B1YLR5
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

262543:EXIG RS14410
gene id: 262543:EXIG_RS14410
uniprot id: B1YF49
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

262543:EXIG RS04460
gene id: 262543:EXIG_RS04460
uniprot id: B1YL75
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

262543:EXIG RS02655
gene id: 262543:EXIG_RS02655
uniprot id: B1YJ35
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

262543:EXIG RS05120
gene id: 262543:EXIG_RS05120
uniprot id: B1YLV5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

262543:EXIG RS02120
gene id: 262543:EXIG_RS02120
uniprot id: B1YIH9
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

262543:EXIG RS02770
gene id: 262543:EXIG_RS02770
uniprot id: B1YJ58
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS12900
gene id: 262543:EXIG_RS12900
uniprot id: B1YM26
names: Similarity
messages: Belongs to the UPF0312 family.

262543:EXIG RS04485
gene id: 262543:EXIG_RS04485
uniprot id: B1YL80
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

262543:EXIG RS03265
gene id: 262543:EXIG_RS03265
uniprot id: B1YJQ5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

262543:EXIG RS09965
gene id: 262543:EXIG_RS09965
uniprot id: B1YIR9
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

262543:EXIG RS04015
gene id: 262543:EXIG_RS04015
uniprot id: B1YKN6
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

262543:EXIG RS10585
gene id: 262543:EXIG_RS10585
uniprot id: B1YJE1
names: Similarity
messages: Belongs to the UPF0473 family.

262543:EXIG RS12125
gene id: 262543:EXIG_RS12125
uniprot id: B1YL28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

262543:EXIG RS10055
gene id: 262543:EXIG_RS10055
uniprot id: B1YIT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).

262543:EXIG RS06575
gene id: 262543:EXIG_RS06575
uniprot id: B1YEX1
names: Similarity
messages: Belongs to the peptidase S8 family.

262543:EXIG RS07340
gene id: 262543:EXIG_RS07340
uniprot id: B1YFV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

262543:EXIG RS06335
gene id: 262543:EXIG_RS06335
uniprot id: B1YES6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

262543:EXIG RS00730
gene id: 262543:EXIG_RS00730
uniprot id: B1YGW2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

262543:EXIG RS00620
gene id: 262543:EXIG_RS00620
uniprot id: B1YGU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

262543:EXIG RS04265
gene id: 262543:EXIG_RS04265
uniprot id: B1YKT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EamA transporter family.
messages: Membrane

262543:EXIG RS12580
gene id: 262543:EXIG_RS12580
uniprot id: B1YLL5
names: Similarity
messages: Belongs to the IMPACT family.

262543:EXIG RS08770
gene id: 262543:EXIG_RS08770
uniprot id: B1YHI6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.
messages: E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
messages: Homodimer. Part of the 2-oxoglutarate dehydrogenase (OGDH) complex composed of E1 (2-oxoglutarate dehydrogenase), E2 (dihydrolipoamide succinyltransferase) and E3 (dihydrolipoamide dehydrogenase); the complex contains multiple copies of the three enzymatic components (E1, E2 and E3).

262543:EXIG RS14585
gene id: 262543:EXIG_RS14585
uniprot id: B1YFI4
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

262543:EXIG RS13405
gene id: 262543:EXIG_RS13405
uniprot id: B1YMM6
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS02895
gene id: 262543:EXIG_RS02895
uniprot id: B1YJI0
names: Similarity
messages: Belongs to the 4-oxalocrotonate tautomerase family.

262543:EXIG RS00690
gene id: 262543:EXIG_RS00690
uniprot id: B1YGV4
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

262543:EXIG RS04630
gene id: 262543:EXIG_RS04630
uniprot id: B1YLA7
names: Similarity
messages: Belongs to the transpeptidase family.

262543:EXIG RS00435
gene id: 262543:EXIG_RS00435
uniprot id: B1YGR5
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

262543:EXIG RS14380
gene id: 262543:EXIG_RS14380
uniprot id: B1YF43
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

262543:EXIG RS03745
gene id: 262543:EXIG_RS03745
uniprot id: B1YK83
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-Y family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.

262543:EXIG RS13075
gene id: 262543:EXIG_RS13075
uniprot id: B1YM60
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

262543:EXIG RS12760
gene id: 262543:EXIG_RS12760
uniprot id: B1YLZ8
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

262543:EXIG RS11510
gene id: 262543:EXIG_RS11510
uniprot id: B1YKF5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

262543:EXIG RS12640
gene id: 262543:EXIG_RS12640
uniprot id: B1YLM7
names: Similarity
messages: Belongs to the acyltransferase 3 family.

262543:EXIG RS02790
gene id: 262543:EXIG_RS02790
uniprot id: B1YJ62
names: Function
names: Similarity
messages: Belongs to the transposase IS30 family.
messages: Required for the transposition of the insertion element.

262543:EXIG RS09780
gene id: 262543:EXIG_RS09780
uniprot id: B1YIN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

262543:EXIG RS01750
gene id: 262543:EXIG_RS01750
uniprot id: B1YI04
names: Similarity
messages: Belongs to the peptidase S51 family.

262543:EXIG RS10935
gene id: 262543:EXIG_RS10935
uniprot id: B1YJV6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

262543:EXIG RS09395
gene id: 262543:EXIG_RS09395
uniprot id: B1YI54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FemABX family.
messages: Cytoplasm

262543:EXIG RS06285
gene id: 262543:EXIG_RS06285
uniprot id: B1YER6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

262543:EXIG RS04915
gene id: 262543:EXIG_RS04915
uniprot id: B1YLR3
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

262543:EXIG RS02140
gene id: 262543:EXIG_RS02140
uniprot id: B1YII3
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

262543:EXIG RS13575
gene id: 262543:EXIG_RS13575
uniprot id: B1YMR0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

262543:EXIG RS07310
gene id: 262543:EXIG_RS07310
uniprot id: B1YFU8
names: Similarity
messages: Belongs to the peptidase S51 family.

262543:EXIG RS07215
gene id: 262543:EXIG_RS07215
uniprot id: B1YFH9
names: Subcellular Location Annotation
messages: Cell membrane

262543:EXIG RS12905
gene id: 262543:EXIG_RS12905
uniprot id: B1YM27
names: Similarity
messages: Belongs to the SMP-30/CGR1 family.

262543:EXIG RS05235
gene id: 262543:EXIG_RS05235
uniprot id: B1YLX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

262543:EXIG RS00825
gene id: 262543:EXIG_RS00825
uniprot id: B1YH82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the energy-coupling factor EcfT family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component). May be able to interact with more than 1 S component at a time (By similarity).
messages: Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.

262543:EXIG RS09855
gene id: 262543:EXIG_RS09855
uniprot id: B1YIP8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

262543:EXIG RS07525
gene id: 262543:EXIG_RS07525
uniprot id: B1YFY3
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS08985
gene id: 262543:EXIG_RS08985
uniprot id: B1YHM6
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

262543:EXIG RS12450
gene id: 262543:EXIG_RS12450
uniprot id: B1YLI9
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

262543:EXIG RS08960
gene id: 262543:EXIG_RS08960
uniprot id: B1YHM1
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

262543:EXIG RS13755
gene id: 262543:EXIG_RS13755
uniprot id: B1YEI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS10355
gene id: 262543:EXIG_RS10355
uniprot id: B1YJ94
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

262543:EXIG RS05035
gene id: 262543:EXIG_RS05035
uniprot id: B1YLT7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS04355
gene id: 262543:EXIG_RS04355
uniprot id: B1YL55
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

262543:EXIG RS08745
gene id: 262543:EXIG_RS08745
uniprot id: B1YHI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS11820
gene id: 262543:EXIG_RS11820
uniprot id: B1YKW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family.
messages: Cell membrane
messages: Membrane
messages: Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex.

262543:EXIG RS01270
gene id: 262543:EXIG_RS01270
uniprot id: B1YHF9
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

262543:EXIG RS06280
gene id: 262543:EXIG_RS06280
uniprot id: B1YER5
names: Similarity
messages: Belongs to the peptidase C40 family.

262543:EXIG RS02500
gene id: 262543:EXIG_RS02500
uniprot id: B1YJ04
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

262543:EXIG RS15260
gene id: 262543:EXIG_RS15260
uniprot id: B1YG62
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

262543:EXIG RS10205
gene id: 262543:EXIG_RS10205
uniprot id: B1YJ63
names: Function
messages: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

262543:EXIG RS06045
gene id: 262543:EXIG_RS06045
uniprot id: B1YEC3
names: Similarity
messages: Belongs to the CbxX/CfxQ family.

262543:EXIG RS03010
gene id: 262543:EXIG_RS03010
uniprot id: B1YJK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

262543:EXIG RS10075
gene id: 262543:EXIG_RS10075
uniprot id: B1YIU1
names: Similarity
messages: Belongs to the transpeptidase family.

262543:EXIG RS04210
gene id: 262543:EXIG_RS04210
uniprot id: B1YKS4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

262543:EXIG RS12545
gene id: 262543:EXIG_RS12545
uniprot id: B1YLK8
names: Similarity
messages: Belongs to the FlgM family.

262543:EXIG RS12585
gene id: 262543:EXIG_RS12585
uniprot id: B1YLL6
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

262543:EXIG RS11945
gene id: 262543:EXIG_RS11945
uniprot id: B1YKZ1
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

262543:EXIG RS02900
gene id: 262543:EXIG_RS02900
uniprot id: B1YJI1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

262543:EXIG RS04230
gene id: 262543:EXIG_RS04230
uniprot id: B1YKS8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

262543:EXIG RS11290
gene id: 262543:EXIG_RS11290
uniprot id: B1YKB1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

262543:EXIG RS08290
gene id: 262543:EXIG_RS08290
uniprot id: B1YH03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.
messages: Membrane

262543:EXIG RS07060
gene id: 262543:EXIG_RS07060
uniprot id: B1YFF0
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS08440
gene id: 262543:EXIG_RS08440
uniprot id: B1YH34
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

262543:EXIG RS02700
gene id: 262543:EXIG_RS02700
uniprot id: B1YJ44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

262543:EXIG RS04625
gene id: 262543:EXIG_RS04625
uniprot id: B1YLA6
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

262543:EXIG RS13745
gene id: 262543:EXIG_RS13745
uniprot id: B1YEI6
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS00120
gene id: 262543:EXIG_RS00120
uniprot id: B1YGC8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

262543:EXIG RS12770
gene id: 262543:EXIG_RS12770
uniprot id: B1YM00
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

262543:EXIG RS06210
gene id: 262543:EXIG_RS06210
uniprot id: B1YEF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched chain amino acid transporter family.
messages: Cell membrane
messages: Component of the transport system for branched-chain amino acids.
messages: Membrane

262543:EXIG RS08765
gene id: 262543:EXIG_RS08765
uniprot id: B1YHI5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
messages: Forms a 24-polypeptide structural core with octahedral symmetry. Part of the 2-oxoglutarate dehydrogenase (OGDH) complex composed of E1 (2-oxoglutarate dehydrogenase), E2 (dihydrolipoamide succinyltransferase) and E3 (dihydrolipoamide dehydrogenase); the complex contains multiple copies of the three enzymatic components (E1, E2 and E3).

262543:EXIG RS13810
gene id: 262543:EXIG_RS13810
uniprot id: B1YEJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS11605
gene id: 262543:EXIG_RS11605
uniprot id: B1YKH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

262543:EXIG RS03730
gene id: 262543:EXIG_RS03730
uniprot id: B1YK80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0754 family.
messages: Cell membrane

262543:EXIG RS02950
gene id: 262543:EXIG_RS02950
uniprot id: B1YJJ2
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

262543:EXIG RS10750
gene id: 262543:EXIG_RS10750
uniprot id: B1YJR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

262543:EXIG RS08485
gene id: 262543:EXIG_RS08485
uniprot id: B1YH43
names: Similarity
messages: Belongs to the Nudix hydrolase family.

262543:EXIG RS08785
gene id: 262543:EXIG_RS08785
uniprot id: B1YHI9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

262543:EXIG RS10770
gene id: 262543:EXIG_RS10770
uniprot id: B1YJS3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

262543:EXIG RS09795
gene id: 262543:EXIG_RS09795
uniprot id: B1YIN5
names: Similarity
messages: Belongs to the fabD family.

262543:EXIG RS09650
gene id: 262543:EXIG_RS09650
uniprot id: B1YIA5
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

262543:EXIG RS04165
gene id: 262543:EXIG_RS04165
uniprot id: B1YKR5
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

262543:EXIG RS04235
gene id: 262543:EXIG_RS04235
uniprot id: B1YKS9
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

262543:EXIG RS10610
gene id: 262543:EXIG_RS10610
uniprot id: B1YJE6
names: Function
names: Similarity
messages: Belongs to the RecD family. RecD-like subfamily.
messages: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity.

262543:EXIG RS01420
gene id: 262543:EXIG_RS01420
uniprot id: B1YHT8
names: Similarity
messages: Belongs to the band 7/mec-2 family. Flotillin subfamily.

262543:EXIG RS03150
gene id: 262543:EXIG_RS03150
uniprot id: B1YJN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS02835
gene id: 262543:EXIG_RS02835
uniprot id: B1YJH0
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS11120
gene id: 262543:EXIG_RS11120
uniprot id: B1YJZ2
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS00300
gene id: 262543:EXIG_RS00300
uniprot id: B1YGP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

262543:EXIG RS12670
gene id: 262543:EXIG_RS12670
uniprot id: B1YLN3
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS13795
gene id: 262543:EXIG_RS13795
uniprot id: B1YEJ6
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

262543:EXIG RS01405
gene id: 262543:EXIG_RS01405
uniprot id: B1YHT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Bcr/CmlA family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS00990
gene id: 262543:EXIG_RS00990
uniprot id: B1YHA3
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated protein Cas5 family. Subtype I-C/Dvulg subfamily.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).

262543:EXIG RS03685
gene id: 262543:EXIG_RS03685
uniprot id: B1YK71
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.
messages: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

262543:EXIG RS10905
gene id: 262543:EXIG_RS10905
uniprot id: B1YJV0
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

262543:EXIG RS00695
gene id: 262543:EXIG_RS00695
uniprot id: B1YGV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).

262543:EXIG RS04665
gene id: 262543:EXIG_RS04665
uniprot id: B1YLB4
names: Similarity
messages: Belongs to the glycosyl hydrolase 57 family.

262543:EXIG RS08200
gene id: 262543:EXIG_RS08200
uniprot id: B1YGY4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase family. ParE type 2 subfamily.
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

262543:EXIG RS13100
gene id: 262543:EXIG_RS13100
uniprot id: B1YM65
names: Similarity
messages: Belongs to the polysaccharide synthase family.

262543:EXIG RS01520
gene id: 262543:EXIG_RS01520
uniprot id: B1YE98
names: Function
names: Similarity
messages: Belongs to the transposase IS30 family.
messages: Required for the transposition of the insertion element.

262543:EXIG RS05775
gene id: 262543:EXIG_RS05775
uniprot id: B1YE67
names: Function
messages: Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.

262543:EXIG RS11335
gene id: 262543:EXIG_RS11335
uniprot id: B1YKC0
names: Similarity
messages: Belongs to the peptidase M24B family.

262543:EXIG RS10640
gene id: 262543:EXIG_RS10640
uniprot id: B1YJF2
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

262543:EXIG RS14140
gene id: 262543:EXIG_RS14140
uniprot id: B1YF09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

262543:EXIG RS12425
gene id: 262543:EXIG_RS12425
uniprot id: B1YLI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

262543:EXIG RS02375
gene id: 262543:EXIG_RS02375
uniprot id: B1YIY2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the RuBisCO large chain family. Type IV subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P).
messages: Has no RuBP-carboxylation activity.
messages: Homodimer.

262543:EXIG RS11930
gene id: 262543:EXIG_RS11930
uniprot id: B1YKY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nlpA lipoprotein family.
messages: Membrane

262543:EXIG RS05795
gene id: 262543:EXIG_RS05795
uniprot id: B1YE71
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

262543:EXIG RS09665
gene id: 262543:EXIG_RS09665
uniprot id: B1YIA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CodY family.
messages: Cytoplasm
messages: DNA-binding global transcriptional regulator which is involved in the adaptive response to starvation and acts by directly or indirectly controlling the expression of numerous genes in response to nutrient availability. During rapid exponential growth, CodY is highly active and represses genes whose products allow adaptation to nutrient depletion.

262543:EXIG RS01445
gene id: 262543:EXIG_RS01445
uniprot id: B1YHU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

262543:EXIG RS14940
gene id: 262543:EXIG_RS14940
uniprot id: B1YFQ6
names: Subcellular Location Annotation
messages: Cytoplasm

262543:EXIG RS09135
gene id: 262543:EXIG_RS09135
uniprot id: B1YHQ7
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

262543:EXIG RS02320
gene id: 262543:EXIG_RS02320
uniprot id: B1YIX1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane

262543:EXIG RS07100
gene id: 262543:EXIG_RS07100
uniprot id: B1YFF8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

262543:EXIG RS09060
gene id: 262543:EXIG_RS09060
uniprot id: B1YHP1
names: Subcellular Location Annotation
messages: Cytoplasm

262543:EXIG RS11585
gene id: 262543:EXIG_RS11585
uniprot id: B1YKH0
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

262543:EXIG RS06145
gene id: 262543:EXIG_RS06145
uniprot id: B1YEE3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

262543:EXIG RS00030
gene id: 262543:EXIG_RS00030
uniprot id: B1YGB7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

262543:EXIG RS11160
gene id: 262543:EXIG_RS11160
uniprot id: B1YK00
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

262543:EXIG RS05190
gene id: 262543:EXIG_RS05190
uniprot id: B1YLW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS14725
gene id: 262543:EXIG_RS14725
uniprot id: B1YFL2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

262543:EXIG RS05340
gene id: 262543:EXIG_RS05340
uniprot id: B1YM96
names: Function
names: Similarity
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

262543:EXIG RS09140
gene id: 262543:EXIG_RS09140
uniprot id: B1YHQ8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

262543:EXIG RS08940
gene id: 262543:EXIG_RS08940
uniprot id: B1YHL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

262543:EXIG RS03110
gene id: 262543:EXIG_RS03110
uniprot id: B1YJM4
names: Similarity
messages: Belongs to the CarB family.

262543:EXIG RS02670
gene id: 262543:EXIG_RS02670
uniprot id: B1YJ38
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

262543:EXIG RS02560
gene id: 262543:EXIG_RS02560
uniprot id: B1YJ16
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

262543:EXIG RS04990
gene id: 262543:EXIG_RS04990
uniprot id: B1YLS8
names: Similarity
messages: Belongs to the diacylglycerol/lipid kinase family.

262543:EXIG RS02620
gene id: 262543:EXIG_RS02620
uniprot id: B1YJ28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LPG synthase family.
messages: Catalyzes the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.
messages: Cell membrane
messages: Membrane

262543:EXIG RS11770
gene id: 262543:EXIG_RS11770
uniprot id: B1YKV7
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS14770
gene id: 262543:EXIG_RS14770
uniprot id: B1YFM1
names: Similarity
messages: Belongs to the UPF0111 family.

262543:EXIG RS03865
gene id: 262543:EXIG_RS03865
uniprot id: B1YKK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 32 family.
messages: Cytoplasm
messages: Enables the bacterium to metabolize sucrose as a sole carbon source.

262543:EXIG RS05335
gene id: 262543:EXIG_RS05335
uniprot id: B1YM95
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

262543:EXIG RS11430
gene id: 262543:EXIG_RS11430
uniprot id: B1YKD9
names: Similarity
messages: Belongs to the histone deacetylase family.

262543:EXIG RS07305
gene id: 262543:EXIG_RS07305
uniprot id: B1YFU7
names: Function
names: Similarity
messages: Belongs to the ROK (NagC/XylR) family.
messages: Transcriptional repressor of xylose-utilizing enzymes.

262543:EXIG RS09295
gene id: 262543:EXIG_RS09295
uniprot id: B1YI35
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protease PrsW family.
messages: Cell membrane
messages: Involved in the degradation of specific anti-sigma factors.
messages: Membrane

262543:EXIG RS09820
gene id: 262543:EXIG_RS09820
uniprot id: B1YIP0
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

262543:EXIG RS05085
gene id: 262543:EXIG_RS05085
uniprot id: B1YLU8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

262543:EXIG RS05185
gene id: 262543:EXIG_RS05185
uniprot id: B1YLW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS13010
gene id: 262543:EXIG_RS13010
uniprot id: B1YM48
names: Similarity
messages: Belongs to the CDP-glycerol glycerophosphotransferase family.

262543:EXIG RS09765
gene id: 262543:EXIG_RS09765
uniprot id: B1YIM9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

262543:EXIG RS12500
gene id: 262543:EXIG_RS12500
uniprot id: B1YLJ9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

262543:EXIG RS02005
gene id: 262543:EXIG_RS02005
uniprot id: B1YIF6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS00105
gene id: 262543:EXIG_RS00105
uniprot id: B1YGC5
names: Similarity
messages: Belongs to the DCK/DGK family.

262543:EXIG RS04450
gene id: 262543:EXIG_RS04450
uniprot id: B1YL73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

262543:EXIG RS04090
gene id: 262543:EXIG_RS04090
uniprot id: B1YKQ1
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

262543:EXIG RS11955
gene id: 262543:EXIG_RS11955
uniprot id: B1YKZ3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LuxS family.
messages: Binds 1 Fe cation per subunit.
messages: Homodimer.
messages: Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).

262543:EXIG RS08805
gene id: 262543:EXIG_RS08805
uniprot id: B1YHJ2
names: Similarity
messages: Belongs to the peptidase S66 family.

262543:EXIG RS13620
gene id: 262543:EXIG_RS13620
uniprot id: B1YEG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.

262543:EXIG RS12890
gene id: 262543:EXIG_RS12890
uniprot id: B1YM24
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

262543:EXIG RS13615
gene id: 262543:EXIG_RS13615
uniprot id: B1YMR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.

262543:EXIG RS11000
gene id: 262543:EXIG_RS11000
uniprot id: B1YJW8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.

262543:EXIG RS06345
gene id: 262543:EXIG_RS06345
uniprot id: B1YES8
names: Similarity
messages: Belongs to the antibiotic N-acetyltransferase family.

262543:EXIG RS01040
gene id: 262543:EXIG_RS01040
uniprot id: B1YHB3
names: Similarity
messages: Belongs to the YjdM family.

262543:EXIG RS12980
gene id: 262543:EXIG_RS12980
uniprot id: B1YM41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

262543:EXIG RS06155
gene id: 262543:EXIG_RS06155
uniprot id: B1YEE5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0719 family.
messages: Membrane

262543:EXIG RS00840
gene id: 262543:EXIG_RS00840
uniprot id: B1YH85
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

262543:EXIG RS09400
gene id: 262543:EXIG_RS09400
uniprot id: B1YI55
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

262543:EXIG RS04995
gene id: 262543:EXIG_RS04995
uniprot id: B1YLS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS01265
gene id: 262543:EXIG_RS01265
uniprot id: B1YHF8
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS10730
gene id: 262543:EXIG_RS10730
uniprot id: B1YJR5
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.

262543:EXIG RS10840
gene id: 262543:EXIG_RS10840
uniprot id: B1YJT7
names: Similarity
messages: Belongs to the GSP E family.

262543:EXIG RS09770
gene id: 262543:EXIG_RS09770
uniprot id: B1YIN0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

262543:EXIG RS05680
gene id: 262543:EXIG_RS05680
uniprot id: B1YMG4
names: Similarity
messages: Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.

262543:EXIG RS00020
gene id: 262543:EXIG_RS00020
uniprot id: B1YGB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.

262543:EXIG RS11675
gene id: 262543:EXIG_RS11675
uniprot id: B1YKI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

262543:EXIG RS13505
gene id: 262543:EXIG_RS13505
uniprot id: B1YMP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

262543:EXIG RS01650
gene id: 262543:EXIG_RS01650
uniprot id: B1YHY5
names: Similarity
messages: Belongs to the extradiol ring-cleavage dioxygenase family.

262543:EXIG RS09450
gene id: 262543:EXIG_RS09450
uniprot id: B1YI65
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

262543:EXIG RS14560
gene id: 262543:EXIG_RS14560
uniprot id: B1YF80
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

262543:EXIG RS10830
gene id: 262543:EXIG_RS10830
uniprot id: B1YJT5
names: Function
messages: Required for transformation and DNA binding.

262543:EXIG RS00675
gene id: 262543:EXIG_RS00675
uniprot id: B1YGV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

262543:EXIG RS11220
gene id: 262543:EXIG_RS11220
uniprot id: B1YK97
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
messages: Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.
messages: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.

262543:EXIG RS04825
gene id: 262543:EXIG_RS04825
uniprot id: B1YLP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

262543:EXIG RS12060
gene id: 262543:EXIG_RS12060
uniprot id: B1YL15
names: Function
names: Subunit
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Heteromultimer composed of HisG and HisZ subunits.

262543:EXIG RS05650
gene id: 262543:EXIG_RS05650
uniprot id: B1YMF8
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

262543:EXIG RS10510
gene id: 262543:EXIG_RS10510
uniprot id: B1YJC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS10795
gene id: 262543:EXIG_RS10795
uniprot id: B1YJS8
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

262543:EXIG RS05570
gene id: 262543:EXIG_RS05570
uniprot id: B1YME2
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS09375
gene id: 262543:EXIG_RS09375
uniprot id: B1YI50
names: Similarity
messages: Belongs to the BMP lipoprotein family.

262543:EXIG RS10090
gene id: 262543:EXIG_RS10090
uniprot id: B1YIU4
names: Function
names: Similarity
messages: Belongs to the BshC family.
messages: Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH.

262543:EXIG RS11180
gene id: 262543:EXIG_RS11180
uniprot id: B1YK04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

262543:EXIG RS00130
gene id: 262543:EXIG_RS00130
uniprot id: B1YGD0
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

262543:EXIG RS04240
gene id: 262543:EXIG_RS04240
uniprot id: B1YKT0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

262543:EXIG RS09985
gene id: 262543:EXIG_RS09985
uniprot id: B1YIS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.
messages: Membrane

262543:EXIG RS10705
gene id: 262543:EXIG_RS10705
uniprot id: B1YJR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

262543:EXIG RS14605
gene id: 262543:EXIG_RS14605
uniprot id: B1YFI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS05830
gene id: 262543:EXIG_RS05830
uniprot id: B1YE78
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS05890
gene id: 262543:EXIG_RS05890
uniprot id: B1YE90
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

262543:EXIG RS02275
gene id: 262543:EXIG_RS02275
uniprot id: B1YIK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS03545
gene id: 262543:EXIG_RS03545
uniprot id: B1YK60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0295 family.
messages: Cell membrane

262543:EXIG RS09505
gene id: 262543:EXIG_RS09505
uniprot id: B1YI76
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

262543:EXIG RS09960
gene id: 262543:EXIG_RS09960
uniprot id: B1YIR8
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrK family.
messages: Binds 1 FAD per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Heterotetramer of 2 PyrK and 2 PyrD type B subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).

262543:EXIG RS15160
gene id: 262543:EXIG_RS15160
uniprot id: B1YG42
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS11920
gene id: 262543:EXIG_RS11920
uniprot id: B1YKY6
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

262543:EXIG RS10625
gene id: 262543:EXIG_RS10625
uniprot id: B1YJE9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm

262543:EXIG RS04750
gene id: 262543:EXIG_RS04750
uniprot id: B1YLD1
names: Function
messages: Required for transformation and DNA binding.

262543:EXIG RS04635
gene id: 262543:EXIG_RS04635
uniprot id: B1YLA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PstS family.
messages: Cell membrane
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

262543:EXIG RS10945
gene id: 262543:EXIG_RS10945
uniprot id: B1YJV8
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

262543:EXIG RS01095
gene id: 262543:EXIG_RS01095
uniprot id: B1YHC4
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS10985
gene id: 262543:EXIG_RS10985
uniprot id: B1YJW5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

262543:EXIG RS02000
gene id: 262543:EXIG_RS02000
uniprot id: B1YIF5
names: Similarity
messages: Belongs to the sulfur carrier protein TusA family.

262543:EXIG RS05160
gene id: 262543:EXIG_RS05160
uniprot id: B1YLW3
names: Subcellular Location Annotation
messages: Cell membrane

262543:EXIG RS14000
gene id: 262543:EXIG_RS14000
uniprot id: B1YEN9
names: Similarity
messages: Belongs to the acyltransferase 3 family.

262543:EXIG RS10655
gene id: 262543:EXIG_RS10655
uniprot id: B1YJF6
names: Similarity
messages: Belongs to the DNA glycosylase MPG family.

262543:EXIG RS10030
gene id: 262543:EXIG_RS10030
uniprot id: B1YIT2
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

262543:EXIG RS11175
gene id: 262543:EXIG_RS11175
uniprot id: B1YK03
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

262543:EXIG RS02145
gene id: 262543:EXIG_RS02145
uniprot id: B1YII4
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

262543:EXIG RS09850
gene id: 262543:EXIG_RS09850
uniprot id: B1YIP7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

262543:EXIG RS10720
gene id: 262543:EXIG_RS10720
uniprot id: B1YJR3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 3 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

262543:EXIG RS05825
gene id: 262543:EXIG_RS05825
uniprot id: B1YE77
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS06060
gene id: 262543:EXIG_RS06060
uniprot id: B1YEC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

262543:EXIG RS08055
gene id: 262543:EXIG_RS08055
uniprot id: B1YGL2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

262543:EXIG RS12120
gene id: 262543:EXIG_RS12120
uniprot id: B1YL27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

262543:EXIG RS12155
gene id: 262543:EXIG_RS12155
uniprot id: B1YL34
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbsD / FucU family. RbsD subfamily.
messages: Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
messages: Cytoplasm
messages: Homodecamer.

262543:EXIG RS03155
gene id: 262543:EXIG_RS03155
uniprot id: B1YJN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS02510
gene id: 262543:EXIG_RS02510
uniprot id: B1YJ06
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

262543:EXIG RS09975
gene id: 262543:EXIG_RS09975
uniprot id: B1YIS1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

262543:EXIG RS09735
gene id: 262543:EXIG_RS09735
uniprot id: B1YIM3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

262543:EXIG RS14175
gene id: 262543:EXIG_RS14175
uniprot id: B1YF16
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

262543:EXIG RS02600
gene id: 262543:EXIG_RS02600
uniprot id: B1YJ24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent.
messages: Homohexamer; The oligomerization is ATP-dependent.
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.

262543:EXIG RS11970
gene id: 262543:EXIG_RS11970
uniprot id: B1YKZ7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

262543:EXIG RS13835
gene id: 262543:EXIG_RS13835
uniprot id: B1YEK4
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

262543:EXIG RS09380
gene id: 262543:EXIG_RS09380
uniprot id: B1YI51
names: Similarity
messages: Belongs to the FtsK/SpoIIIE/SftA family.

262543:EXIG RS09995
gene id: 262543:EXIG_RS09995
uniprot id: B1YIS5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

262543:EXIG RS13645
gene id: 262543:EXIG_RS13645
uniprot id: B1YEG6
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

262543:EXIG RS12010
gene id: 262543:EXIG_RS12010
uniprot id: B1YL05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS11240
gene id: 262543:EXIG_RS11240
uniprot id: B1YKA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
messages: Single-chain monomer with multiple functions.

262543:EXIG RS10065
gene id: 262543:EXIG_RS10065
uniprot id: B1YIT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

262543:EXIG RS07400
gene id: 262543:EXIG_RS07400
uniprot id: B1YFW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArsB family.
messages: Cell membrane
messages: Involved in arsenical resistance. Thought to form the channel of an arsenite pump.
messages: Membrane

262543:EXIG RS02215
gene id: 262543:EXIG_RS02215
uniprot id: B1YIJ8
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

262543:EXIG RS00670
gene id: 262543:EXIG_RS00670
uniprot id: B1YGV0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

262543:EXIG RS10800
gene id: 262543:EXIG_RS10800
uniprot id: B1YJS9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

262543:EXIG RS09240
gene id: 262543:EXIG_RS09240
uniprot id: B1YI24
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

262543:EXIG RS12705
gene id: 262543:EXIG_RS12705
uniprot id: B1YLY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS15480
gene id: 262543:EXIG_RS15480
uniprot id: B1YGA7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

262543:EXIG RS00735
gene id: 262543:EXIG_RS00735
uniprot id: B1YGW3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

262543:EXIG RS11150
gene id: 262543:EXIG_RS11150
uniprot id: B1YJZ8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

262543:EXIG RS05380
gene id: 262543:EXIG_RS05380
uniprot id: B1YMA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ScpB family.
messages: Cytoplasm
messages: Homodimer. Homodimerization may be required to stabilize the binding of ScpA to the Smc head domains. Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.
messages: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.

262543:EXIG RS10700
gene id: 262543:EXIG_RS10700
uniprot id: B1YJQ9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

262543:EXIG RS11245
gene id: 262543:EXIG_RS11245
uniprot id: B1YKA2
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS02740
gene id: 262543:EXIG_RS02740
uniprot id: B1YJ52
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Cell membrane
messages: Membrane

262543:EXIG RS11775
gene id: 262543:EXIG_RS11775
uniprot id: B1YKV8
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS06875
gene id: 262543:EXIG_RS06875
uniprot id: B1YFB4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Cell membrane
messages: Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
messages: Membrane

262543:EXIG RS08205
gene id: 262543:EXIG_RS08205
uniprot id: B1YGY5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

262543:EXIG RS13590
gene id: 262543:EXIG_RS13590
uniprot id: B1YMR3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

262543:EXIG RS14965
gene id: 262543:EXIG_RS14965
uniprot id: B1YFR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M4 family.
messages: Extracellular zinc metalloprotease.
messages: Secreted

262543:EXIG RS01575
gene id: 262543:EXIG_RS01575
uniprot id: B1YHX0
names: Similarity
messages: Belongs to the Nudix hydrolase family.

262543:EXIG RS12995
gene id: 262543:EXIG_RS12995
uniprot id: B1YM45
names: Similarity
messages: Belongs to the glutathione peroxidase family.

262543:EXIG RS01255
gene id: 262543:EXIG_RS01255
uniprot id: B1YHF6
names: Caution
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

262543:EXIG RS02520
gene id: 262543:EXIG_RS02520
uniprot id: B1YJ08
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

262543:EXIG RS10345
gene id: 262543:EXIG_RS10345
uniprot id: B1YJ92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsbB family. BdbC subfamily.
messages: Membrane

262543:EXIG RS04375
gene id: 262543:EXIG_RS04375
uniprot id: B1YL59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Membrane

262543:EXIG RS09020
gene id: 262543:EXIG_RS09020
uniprot id: B1YHN3
names: Similarity
messages: Belongs to the diacylglycerol/lipid kinase family.

262543:EXIG RS07725
gene id: 262543:EXIG_RS07725
uniprot id: B1YGE5
names: Similarity
messages: Belongs to the Nudix hydrolase family.

262543:EXIG RS00755
gene id: 262543:EXIG_RS00755
uniprot id: B1YGW7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

262543:EXIG RS08820
gene id: 262543:EXIG_RS08820
uniprot id: B1YHJ5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

262543:EXIG RS14480
gene id: 262543:EXIG_RS14480
uniprot id: B1YF63
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

262543:EXIG RS11960
gene id: 262543:EXIG_RS11960
uniprot id: B1YKZ4
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. YrrT family.
messages: Could be a S-adenosyl-L-methionine-dependent methyltransferase.

262543:EXIG RS00330
gene id: 262543:EXIG_RS00330
uniprot id: B1YGP6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

262543:EXIG RS05710
gene id: 262543:EXIG_RS05710
uniprot id: B1YMH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Monomer.

262543:EXIG RS08685
gene id: 262543:EXIG_RS08685
uniprot id: B1YHG9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

262543:EXIG RS14820
gene id: 262543:EXIG_RS14820
uniprot id: B1YFN1
names: Subcellular Location Annotation
messages: Membrane

262543:EXIG RS02360
gene id: 262543:EXIG_RS02360
uniprot id: B1YIX9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acireductone dioxygenase (ARD) family.
messages: Binds 1 Fe(2+) cation per monomer.
messages: Binds 1 nickel ion per monomer.
messages: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
messages: Monomer.

262543:EXIG RS11110
gene id: 262543:EXIG_RS11110
uniprot id: B1YJZ0
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

262543:EXIG RS10885
gene id: 262543:EXIG_RS10885
uniprot id: B1YJU6
names: Similarity
messages: Belongs to the folylpolyglutamate synthase family.

262543:EXIG RS02265
gene id: 262543:EXIG_RS02265
uniprot id: B1YIK7
names: Similarity
messages: Belongs to the peptidase C40 family.

262543:EXIG RS00750
gene id: 262543:EXIG_RS00750
uniprot id: B1YGW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

262543:EXIG RS05385
gene id: 262543:EXIG_RS05385
uniprot id: B1YMA5
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

262543:EXIG RS15050
gene id: 262543:EXIG_RS15050
uniprot id: B1YFS8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20B family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cleaves the N-terminal amino acid of tripeptides.
messages: Cytoplasm

262543:EXIG RS11910
gene id: 262543:EXIG_RS11910
uniprot id: B1YKY4
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

262543:EXIG RS03390
gene id: 262543:EXIG_RS03390
uniprot id: B1YK29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MenA family. Type 1 subfamily.
messages: Cell membrane
messages: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).
messages: Membrane

262543:EXIG RS07300
gene id: 262543:EXIG_RS07300
uniprot id: B1YFU6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

262543:EXIG RS02555
gene id: 262543:EXIG_RS02555
uniprot id: B1YJ15
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GGGP/HepGP synthase family. Group I subfamily.
messages: Homodimer.
messages: Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales.

262543:EXIG RS09310
gene id: 262543:EXIG_RS09310
uniprot id: B1YI38
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

262543:EXIG RS00820
gene id: 262543:EXIG_RS00820
uniprot id: B1YH81
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).
messages: Membrane

262543:EXIG RS02525
gene id: 262543:EXIG_RS02525
uniprot id: B1YJ09
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

262543:EXIG RS11375
gene id: 262543:EXIG_RS11375
uniprot id: B1YKC8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

262543:EXIG RS12975
gene id: 262543:EXIG_RS12975
uniprot id: B1YM40
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpC family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

262543:EXIG RS03445
gene id: 262543:EXIG_RS03445
uniprot id: B1YK40
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

262543:EXIG RS00055
gene id: 262543:EXIG_RS00055
uniprot id: B1YGB9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

262543:EXIG RS02690
gene id: 262543:EXIG_RS02690
uniprot id: B1YJ42
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.