2590869:FJQ89 RS18700
gene id: 2590869:FJQ89_RS18700
uniprot id: A0A4Y6RID8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

2590869:FJQ89 RS10495
gene id: 2590869:FJQ89_RS10495
uniprot id: A0A4Y6REH0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

2590869:FJQ89 RS19145
gene id: 2590869:FJQ89_RS19145
uniprot id: A0A4Y6RH19
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

2590869:FJQ89 RS19760
gene id: 2590869:FJQ89_RS19760
uniprot id: A0A4Y6RHI3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

2590869:FJQ89 RS09705
gene id: 2590869:FJQ89_RS09705
uniprot id: A0A4Y6RCE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

2590869:FJQ89 RS18580
gene id: 2590869:FJQ89_RS18580
uniprot id: A0A4Y6RGW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

2590869:FJQ89 RS12555
gene id: 2590869:FJQ89_RS12555
uniprot id: A0A4Y6RFE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

2590869:FJQ89 RS27470
gene id: 2590869:FJQ89_RS27470
uniprot id: A0A4Y6RLC3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FlhD family.
messages: Cytoplasm
messages: Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.
messages: Homodimer; disulfide-linked. Forms a heterohexamer composed of two FlhC and four FlhD subunits. Each FlhC binds a FlhD dimer, forming a heterotrimer, and a hexamer assembles by dimerization of two heterotrimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The C-terminal region contains a putative helix-turn-helix (HTH) motif, suggesting that this region may bind DNA.

2590869:FJQ89 RS14875
gene id: 2590869:FJQ89_RS14875
uniprot id: A0A4Y6REW4
names: Function
names: Similarity
messages: ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
messages: Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.

2590869:FJQ89 RS17165
gene id: 2590869:FJQ89_RS17165
uniprot id: A0A4Y6RHP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

2590869:FJQ89 RS23605
gene id: 2590869:FJQ89_RS23605
uniprot id: A0A4Y6RLC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

2590869:FJQ89 RS15730
gene id: 2590869:FJQ89_RS15730
uniprot id: A0A4Y6RFB6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

2590869:FJQ89 RS19865
gene id: 2590869:FJQ89_RS19865
uniprot id: A0A4Y6RJ69
names: Cofactor
names: Similarity
messages: Belongs to the 4HPPD family.
messages: Binds 1 Fe cation per subunit.

2590869:FJQ89 RS17610
gene id: 2590869:FJQ89_RS17610
uniprot id: A0A4Y6RGG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

2590869:FJQ89 RS14590
gene id: 2590869:FJQ89_RS14590
uniprot id: A0A4Y6RNX0
names: Cofactor
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.

2590869:FJQ89 RS01060
gene id: 2590869:FJQ89_RS01060
uniprot id: A0A4Y6R9M9
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2590869:FJQ89 RS20415
gene id: 2590869:FJQ89_RS20415
uniprot id: A0A4Y6RIT6
names: Function
names: Similarity
messages: Belongs to the frataxin family.
messages: Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.

2590869:FJQ89 RS20295
gene id: 2590869:FJQ89_RS20295
uniprot id: A0A4Y6RJ68
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

2590869:FJQ89 RS17675
gene id: 2590869:FJQ89_RS17675
uniprot id: A0A4Y6RHF9
names: Similarity
messages: Belongs to the BolA/IbaG family.

2590869:FJQ89 RS19345
gene id: 2590869:FJQ89_RS19345
uniprot id: A0A4Y6RI89
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

2590869:FJQ89 RS20320
gene id: 2590869:FJQ89_RS20320
uniprot id: A0A4Y6RHT9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

2590869:FJQ89 RS20285
gene id: 2590869:FJQ89_RS20285
uniprot id: A0A4Y6RHK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

2590869:FJQ89 RS21795
gene id: 2590869:FJQ89_RS21795
uniprot id: A0A4Y6RIC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

2590869:FJQ89 RS23615
gene id: 2590869:FJQ89_RS23615
uniprot id: A0A4Y6RKX3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

2590869:FJQ89 RS20150
gene id: 2590869:FJQ89_RS20150
uniprot id: A0A4Y6RIN7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

2590869:FJQ89 RS10485
gene id: 2590869:FJQ89_RS10485
uniprot id: A0A4Y6RCS0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2590869:FJQ89 RS05190
gene id: 2590869:FJQ89_RS05190
uniprot id: A0A4Y6RBV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Cell membrane
messages: Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
messages: Heterooctamer of two A chains, two B chains, two C chains and two D chains.
messages: Membrane

2590869:FJQ89 RS15650
gene id: 2590869:FJQ89_RS15650
uniprot id: A0A4Y6RFJ2
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

2590869:FJQ89 RS25290
gene id: 2590869:FJQ89_RS25290
uniprot id: A0A4Y6RK94
names: Subcellular Location Annotation
messages: Cytoplasm

2590869:FJQ89 RS26525
gene id: 2590869:FJQ89_RS26525
uniprot id: A0A4Y6RMD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ElaB/YgaM/YqjD family.
messages: Cell inner membrane
messages: Membrane

2590869:FJQ89 RS10640
gene id: 2590869:FJQ89_RS10640
uniprot id: A0A4Y6RE14
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

2590869:FJQ89 RS05195
gene id: 2590869:FJQ89_RS05195
uniprot id: A0A4Y6RA86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

2590869:FJQ89 RS15750
gene id: 2590869:FJQ89_RS15750
uniprot id: A0A4Y6RFC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

2590869:FJQ89 RS10585
gene id: 2590869:FJQ89_RS10585
uniprot id: A0A4Y6RES8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

2590869:FJQ89 RS12575
gene id: 2590869:FJQ89_RS12575
uniprot id: A0A4Y6RFK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Membrane

2590869:FJQ89 RS09825
gene id: 2590869:FJQ89_RS09825
uniprot id: A0A4Y6RCD5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RlmJ family.
messages: Monomer.
messages: Specifically methylates the adenine in position 2030 of 23S rRNA.

2590869:FJQ89 RS14930
gene id: 2590869:FJQ89_RS14930
uniprot id: A0A4Y6RGM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpC family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

2590869:FJQ89 RS16520
gene id: 2590869:FJQ89_RS16520
uniprot id: A0A4Y6RP98
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2590869:FJQ89 RS11665
gene id: 2590869:FJQ89_RS11665
uniprot id: A0A4Y6RFB5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

2590869:FJQ89 RS10510
gene id: 2590869:FJQ89_RS10510
uniprot id: A0A4Y6RD41
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

2590869:FJQ89 RS20215
gene id: 2590869:FJQ89_RS20215
uniprot id: A0A4Y6RHI1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

2590869:FJQ89 RS11775
gene id: 2590869:FJQ89_RS11775
uniprot id: A0A4Y6REJ8
names: Similarity
messages: Belongs to the universal stress protein A family.

2590869:FJQ89 RS25935
gene id: 2590869:FJQ89_RS25935
uniprot id: A0A4Y6RPD9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

2590869:FJQ89 RS21740
gene id: 2590869:FJQ89_RS21740
uniprot id: A0A4Y6RIB7
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

2590869:FJQ89 RS27525
gene id: 2590869:FJQ89_RS27525
uniprot id: A0A4Y6RMU7
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

2590869:FJQ89 RS24660
gene id: 2590869:FJQ89_RS24660
uniprot id: A0A4Y6RLW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

2590869:FJQ89 RS12705
gene id: 2590869:FJQ89_RS12705
uniprot id: A0A4Y6RFG1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sigma-70 factor family. FliA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes.

2590869:FJQ89 RS09805
gene id: 2590869:FJQ89_RS09805
uniprot id: A0A4Y6RCN9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

2590869:FJQ89 RS16510
gene id: 2590869:FJQ89_RS16510
uniprot id: A0A4Y6RHD4
names: Similarity
names: Subunit
messages: Belongs to the Nudix hydrolase family. NudJ subfamily.
messages: Monomer.

2590869:FJQ89 RS25540
gene id: 2590869:FJQ89_RS25540
uniprot id: A0A4Y6RKC1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

2590869:FJQ89 RS05045
gene id: 2590869:FJQ89_RS05045
uniprot id: A0A4Y6RAE3
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

2590869:FJQ89 RS13990
gene id: 2590869:FJQ89_RS13990
uniprot id: A0A4Y6RG40
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

2590869:FJQ89 RS18720
gene id: 2590869:FJQ89_RS18720
uniprot id: A0A4Y6RGT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

2590869:FJQ89 RS17095
gene id: 2590869:FJQ89_RS17095
uniprot id: A0A4Y6RG83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

2590869:FJQ89 RS10690
gene id: 2590869:FJQ89_RS10690
uniprot id: A0A4Y6REV8
names: Similarity
messages: Belongs to the adrenodoxin/putidaredoxin family.

2590869:FJQ89 RS23100
gene id: 2590869:FJQ89_RS23100
uniprot id: A0A4Y6RKN4
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

2590869:FJQ89 RS25870
gene id: 2590869:FJQ89_RS25870
uniprot id: A0A4Y6RKJ0
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

2590869:FJQ89 RS11680
gene id: 2590869:FJQ89_RS11680
uniprot id: A0A4Y6RMD6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

2590869:FJQ89 RS18985
gene id: 2590869:FJQ89_RS18985
uniprot id: A0A4Y6RH57
names: Subcellular Location Annotation
messages: Membrane

2590869:FJQ89 RS24135
gene id: 2590869:FJQ89_RS24135
uniprot id: A0A4Y6RLL9
names: Cofactor
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.

2590869:FJQ89 RS00155
gene id: 2590869:FJQ89_RS00155
uniprot id: A0A4Y6R7R5
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

2590869:FJQ89 RS10540
gene id: 2590869:FJQ89_RS10540
uniprot id: A0A4Y6REE9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

2590869:FJQ89 RS21660
gene id: 2590869:FJQ89_RS21660
uniprot id: A0A4Y6RJW4
names: Similarity
messages: Belongs to the P(II) protein family.

2590869:FJQ89 RS15710
gene id: 2590869:FJQ89_RS15710
uniprot id: A0A4Y6RGX6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

2590869:FJQ89 RS22700
gene id: 2590869:FJQ89_RS22700
uniprot id: A0A4Y6RIR5
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family. Prx5 subfamily.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

2590869:FJQ89 RS17770
gene id: 2590869:FJQ89_RS17770
uniprot id: A0A4Y6RGJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

2590869:FJQ89 RS17570
gene id: 2590869:FJQ89_RS17570
uniprot id: A0A4Y6RIA7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2590869:FJQ89 RS01165
gene id: 2590869:FJQ89_RS01165
uniprot id: A0A4Y6R8H6
names: Similarity
messages: Belongs to the hemerythrin family.

2590869:FJQ89 RS20165
gene id: 2590869:FJQ89_RS20165
uniprot id: A0A4Y6RHR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

2590869:FJQ89 RS20240
gene id: 2590869:FJQ89_RS20240
uniprot id: A0A4Y6RHR3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

2590869:FJQ89 RS19610
gene id: 2590869:FJQ89_RS19610
uniprot id: A0A4Y6RHF5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell inner membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

2590869:FJQ89 RS03940
gene id: 2590869:FJQ89_RS03940
uniprot id: A0A4Y6R9V7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

2590869:FJQ89 RS02165
gene id: 2590869:FJQ89_RS02165
uniprot id: A0A4Y6R8T3
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

2590869:FJQ89 RS22410
gene id: 2590869:FJQ89_RS22410
uniprot id: A0A4Y6RKC2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Cell membrane
messages: Membrane
messages: Periplasm
messages: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

2590869:FJQ89 RS08180
gene id: 2590869:FJQ89_RS08180
uniprot id: A0A4Y6RBZ0
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

2590869:FJQ89 RS23360
gene id: 2590869:FJQ89_RS23360
uniprot id: A0A4Y6RJ47
names: Similarity
messages: Belongs to the ABC transporter superfamily.

2590869:FJQ89 RS20810
gene id: 2590869:FJQ89_RS20810
uniprot id: A0A4Y6RI22
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

2590869:FJQ89 RS17645
gene id: 2590869:FJQ89_RS17645
uniprot id: A0A4Y6RI36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

2590869:FJQ89 RS17250
gene id: 2590869:FJQ89_RS17250
uniprot id: A0A4Y6RG63
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

2590869:FJQ89 RS10650
gene id: 2590869:FJQ89_RS10650
uniprot id: A0A4Y6RCV3
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

2590869:FJQ89 RS01550
gene id: 2590869:FJQ89_RS01550
uniprot id: A0A4Y6R8I7
names: Similarity
messages: Belongs to the peptidase S11 family.

2590869:FJQ89 RS07435
gene id: 2590869:FJQ89_RS07435
uniprot id: A0A4Y6RCF8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

2590869:FJQ89 RS20340
gene id: 2590869:FJQ89_RS20340
uniprot id: A0A4Y6RHU0
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

2590869:FJQ89 RS22215
gene id: 2590869:FJQ89_RS22215
uniprot id: A0A4Y6RKE8
names: Subcellular Location Annotation
messages: Membrane

2590869:FJQ89 RS11675
gene id: 2590869:FJQ89_RS11675
uniprot id: A0A4Y6REY0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

2590869:FJQ89 RS21750
gene id: 2590869:FJQ89_RS21750
uniprot id: A0A4Y6RJX4
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

2590869:FJQ89 RS24155
gene id: 2590869:FJQ89_RS24155
uniprot id: A0A4Y6RJN6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

2590869:FJQ89 RS15965
gene id: 2590869:FJQ89_RS15965
uniprot id: A0A4Y6RH51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

2590869:FJQ89 RS11190
gene id: 2590869:FJQ89_RS11190
uniprot id: A0A4Y6REP9
names: Similarity
messages: Belongs to the citrate synthase family.

2590869:FJQ89 RS15660
gene id: 2590869:FJQ89_RS15660
uniprot id: A0A4Y6RHD0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
messages: One is catalytic and the other provides a structural contribution.

2590869:FJQ89 RS11200
gene id: 2590869:FJQ89_RS11200
uniprot id: A0A4Y6RDD3
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

2590869:FJQ89 RS12445
gene id: 2590869:FJQ89_RS12445
uniprot id: A0A4Y6RDZ5
names: Similarity
messages: Belongs to the YicC/YloC family.

2590869:FJQ89 RS22060
gene id: 2590869:FJQ89_RS22060
uniprot id: A0A4Y6RIH7
names: Similarity
messages: Belongs to the transcriptional regulatory Fis family.

2590869:FJQ89 RS14610
gene id: 2590869:FJQ89_RS14610
uniprot id: A0A4Y6RGU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

2590869:FJQ89 RS16290
gene id: 2590869:FJQ89_RS16290
uniprot id: A0A4Y6RFV7
names: Similarity
messages: Belongs to the DNA polymerase HolA subunit family.

2590869:FJQ89 RS11660
gene id: 2590869:FJQ89_RS11660
uniprot id: A0A4Y6REX0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

2590869:FJQ89 RS03450
gene id: 2590869:FJQ89_RS03450
uniprot id: A0A4Y6R9F4
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

2590869:FJQ89 RS19025
gene id: 2590869:FJQ89_RS19025
uniprot id: A0A4Y6RIJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Cell inner membrane
messages: Membrane

2590869:FJQ89 RS10530
gene id: 2590869:FJQ89_RS10530
uniprot id: A0A4Y6RNP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2590869:FJQ89 RS25585
gene id: 2590869:FJQ89_RS25585
uniprot id: A0A4Y6RKE2
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

2590869:FJQ89 RS01790
gene id: 2590869:FJQ89_RS01790
uniprot id: A0A4Y6R8T0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Membrane

2590869:FJQ89 RS12625
gene id: 2590869:FJQ89_RS12625
uniprot id: A0A4Y6RE20
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgI family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

2590869:FJQ89 RS01700
gene id: 2590869:FJQ89_RS01700
uniprot id: A0A4Y6R8H3
names: Function
names: Similarity
messages: Belongs to the FlgM family.
messages: Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA.

2590869:FJQ89 RS07810
gene id: 2590869:FJQ89_RS07810
uniprot id: A0A4Y6RDE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
messages: The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE).

2590869:FJQ89 RS22020
gene id: 2590869:FJQ89_RS22020
uniprot id: A0A4Y6RK25
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HesB/IscA family.
messages: Binds 1 iron-sulfur cluster per subunit.
messages: Homodimer.
messages: Required for insertion of 4Fe-4S clusters.

2590869:FJQ89 RS08880
gene id: 2590869:FJQ89_RS08880
uniprot id: A0A4Y6RDQ7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

2590869:FJQ89 RS12635
gene id: 2590869:FJQ89_RS12635
uniprot id: A0A4Y6RDZ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

2590869:FJQ89 RS25265
gene id: 2590869:FJQ89_RS25265
uniprot id: A0A4Y6RLP7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

2590869:FJQ89 RS17090
gene id: 2590869:FJQ89_RS17090
uniprot id: A0A4Y6RG02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

2590869:FJQ89 RS10705
gene id: 2590869:FJQ89_RS10705
uniprot id: A0A4Y6RCW4
names: Similarity
messages: Belongs to the HesB/IscA family.

2590869:FJQ89 RS12155
gene id: 2590869:FJQ89_RS12155
uniprot id: A0A4Y6RER2
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2590869:FJQ89 RS13115
gene id: 2590869:FJQ89_RS13115
uniprot id: A0A4Y6RF81
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

2590869:FJQ89 RS01895
gene id: 2590869:FJQ89_RS01895
uniprot id: A0A4Y6R8P1
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

2590869:FJQ89 RS17420
gene id: 2590869:FJQ89_RS17420
uniprot id: A0A4Y6RGE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

2590869:FJQ89 RS15880
gene id: 2590869:FJQ89_RS15880
uniprot id: A0A4Y6RFE9
names: Similarity
messages: Belongs to the glutamine synthetase family.

2590869:FJQ89 RS16105
gene id: 2590869:FJQ89_RS16105
uniprot id: A0A4Y6RFS7
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

2590869:FJQ89 RS24930
gene id: 2590869:FJQ89_RS24930
uniprot id: A0A4Y6RLK2
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

2590869:FJQ89 RS02250
gene id: 2590869:FJQ89_RS02250
uniprot id: A0A4Y6RAM1
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.

2590869:FJQ89 RS01040
gene id: 2590869:FJQ89_RS01040
uniprot id: A0A4Y6R8F0
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

2590869:FJQ89 RS20255
gene id: 2590869:FJQ89_RS20255
uniprot id: A0A4Y6RIQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

2590869:FJQ89 RS01675
gene id: 2590869:FJQ89_RS01675
uniprot id: A0A4Y6R9X6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

2590869:FJQ89 RS15420
gene id: 2590869:FJQ89_RS15420
uniprot id: A0A4Y6RGC2
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

2590869:FJQ89 RS13340
gene id: 2590869:FJQ89_RS13340
uniprot id: A0A4Y6RG57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

2590869:FJQ89 RS27895
gene id: 2590869:FJQ89_RS27895
uniprot id: A0A4Y6RLG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

2590869:FJQ89 RS21990
gene id: 2590869:FJQ89_RS21990
uniprot id: A0A4Y6RID4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COQ7 family.
messages: Binds 2 iron ions per subunit.
messages: Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
messages: Cell membrane

2590869:FJQ89 RS01745
gene id: 2590869:FJQ89_RS01745
uniprot id: A0A4Y6R8G7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

2590869:FJQ89 RS20275
gene id: 2590869:FJQ89_RS20275
uniprot id: A0A4Y6RJE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

2590869:FJQ89 RS22415
gene id: 2590869:FJQ89_RS22415
uniprot id: A0A4Y6RIL6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Cell membrane
messages: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
messages: Membrane

2590869:FJQ89 RS17075
gene id: 2590869:FJQ89_RS17075
uniprot id: A0A4Y6RHU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

2590869:FJQ89 RS03945
gene id: 2590869:FJQ89_RS03945
uniprot id: A0A4Y6RB67
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

2590869:FJQ89 RS01245
gene id: 2590869:FJQ89_RS01245
uniprot id: A0A4Y6R9C5
names: Similarity
messages: Belongs to the BlaI transcriptional regulatory family.

2590869:FJQ89 RS23285
gene id: 2590869:FJQ89_RS23285
uniprot id: A0A4Y6RJ11
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

2590869:FJQ89 RS19090
gene id: 2590869:FJQ89_RS19090
uniprot id: A0A4Y6RIS2
names: Similarity
messages: Belongs to the OsmC/Ohr family.

2590869:FJQ89 RS20225
gene id: 2590869:FJQ89_RS20225
uniprot id: A0A4Y6RJD6
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

2590869:FJQ89 RS08755
gene id: 2590869:FJQ89_RS08755
uniprot id: A0A4Y6RBZ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

2590869:FJQ89 RS20260
gene id: 2590869:FJQ89_RS20260
uniprot id: A0A4Y6RJ77
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

2590869:FJQ89 RS16595
gene id: 2590869:FJQ89_RS16595
uniprot id: A0A4Y6RG12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterioferritin family.
messages: Iron-storage protein.
messages: Oligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.

2590869:FJQ89 RS23440
gene id: 2590869:FJQ89_RS23440
uniprot id: A0A4Y6RKU2
names: Similarity
messages: Belongs to the glutamine synthetase family.

2590869:FJQ89 RS07760
gene id: 2590869:FJQ89_RS07760
uniprot id: A0A4Y6RCL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

2590869:FJQ89 RS23600
gene id: 2590869:FJQ89_RS23600
uniprot id: A0A4Y6RMM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

2590869:FJQ89 RS20735
gene id: 2590869:FJQ89_RS20735
uniprot id: A0A4Y6RJG8
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

2590869:FJQ89 RS25945
gene id: 2590869:FJQ89_RS25945
uniprot id: A0A4Y6RKK1
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

2590869:FJQ89 RS18715
gene id: 2590869:FJQ89_RS18715
uniprot id: A0A4Y6RIK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

2590869:FJQ89 RS24960
gene id: 2590869:FJQ89_RS24960
uniprot id: A0A4Y6RK41
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2590869:FJQ89 RS20245
gene id: 2590869:FJQ89_RS20245
uniprot id: A0A4Y6RJ58
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

2590869:FJQ89 RS12700
gene id: 2590869:FJQ89_RS12700
uniprot id: A0A4Y6RE48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

2590869:FJQ89 RS18765
gene id: 2590869:FJQ89_RS18765
uniprot id: A0A4Y6RIL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0719 family.
messages: Membrane

2590869:FJQ89 RS19590
gene id: 2590869:FJQ89_RS19590
uniprot id: A0A4Y6RHF8
names: Similarity
messages: Belongs to the GST superfamily. HSP26 family.

2590869:FJQ89 RS04810
gene id: 2590869:FJQ89_RS04810
uniprot id: A0A4Y6RA16
names: Cofactor
messages: Binds 1 zinc ion per subunit.

2590869:FJQ89 RS20305
gene id: 2590869:FJQ89_RS20305
uniprot id: A0A4Y6RIR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

2590869:FJQ89 RS22000
gene id: 2590869:FJQ89_RS22000
uniprot id: A0A4Y6RKA0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

2590869:FJQ89 RS10710
gene id: 2590869:FJQ89_RS10710
uniprot id: A0A4Y6RD58
names: Function
names: Similarity
messages: A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
messages: Belongs to the NifU family.

2590869:FJQ89 RS14005
gene id: 2590869:FJQ89_RS14005
uniprot id: A0A4Y6RGB6
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

2590869:FJQ89 RS12865
gene id: 2590869:FJQ89_RS12865
uniprot id: A0A4Y6RE69
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

2590869:FJQ89 RS14355
gene id: 2590869:FJQ89_RS14355
uniprot id: A0A4Y6RES5
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit A family.

2590869:FJQ89 RS20685
gene id: 2590869:FJQ89_RS20685
uniprot id: A0A4Y6RJF8
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
messages: Homohexamer.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

2590869:FJQ89 RS15955
gene id: 2590869:FJQ89_RS15955
uniprot id: A0A4Y6RHI8
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

2590869:FJQ89 RS19975
gene id: 2590869:FJQ89_RS19975
uniprot id: A0A4Y6RJ04
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

2590869:FJQ89 RS07975
gene id: 2590869:FJQ89_RS07975
uniprot id: A0A4Y6RD08
names: Similarity
messages: Belongs to the ABC transporter superfamily.

2590869:FJQ89 RS19810
gene id: 2590869:FJQ89_RS19810
uniprot id: A0A4Y6RHJ7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

2590869:FJQ89 RS19640
gene id: 2590869:FJQ89_RS19640
uniprot id: A0A4Y6RIV6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecB family.
messages: Cytoplasm
messages: Homotetramer, a dimer of dimers. One homotetramer interacts with 1 SecA dimer.
messages: One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.

2590869:FJQ89 RS02100
gene id: 2590869:FJQ89_RS02100
uniprot id: A0A4Y6RAJ8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

2590869:FJQ89 RS13140
gene id: 2590869:FJQ89_RS13140
uniprot id: A0A4Y6RE70
names: Similarity
messages: Belongs to the barstar family.

2590869:FJQ89 RS20265
gene id: 2590869:FJQ89_RS20265
uniprot id: A0A4Y6RHJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

2590869:FJQ89 RS22765
gene id: 2590869:FJQ89_RS22765
uniprot id: A0A4Y6RKN9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA gyrase inhibitor YacG family.
messages: Binds 1 zinc ion.
messages: Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
messages: Interacts with GyrB.

2590869:FJQ89 RS15410
gene id: 2590869:FJQ89_RS15410
uniprot id: A0A4Y6RGS6
names: Similarity
messages: Belongs to the thioredoxin family.

2590869:FJQ89 RS08765
gene id: 2590869:FJQ89_RS08765
uniprot id: A0A4Y6RC94
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

2590869:FJQ89 RS19765
gene id: 2590869:FJQ89_RS19765
uniprot id: A0A4Y6RJ49
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DksA family.
messages: Cytoplasm
messages: Interacts directly with the RNA polymerase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters.

2590869:FJQ89 RS24880
gene id: 2590869:FJQ89_RS24880
uniprot id: A0A4Y6RLJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2590869:FJQ89 RS13335
gene id: 2590869:FJQ89_RS13335
uniprot id: A0A4Y6RFS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

2590869:FJQ89 RS06105
gene id: 2590869:FJQ89_RS06105
uniprot id: A0A4Y6RC40
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

2590869:FJQ89 RS20270
gene id: 2590869:FJQ89_RS20270
uniprot id: A0A4Y6RHS9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

2590869:FJQ89 RS12150
gene id: 2590869:FJQ89_RS12150
uniprot id: A0A4Y6RFK0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

2590869:FJQ89 RS17330
gene id: 2590869:FJQ89_RS17330
uniprot id: A0A4Y6RHB0
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

2590869:FJQ89 RS20330
gene id: 2590869:FJQ89_RS20330
uniprot id: A0A4Y6RHM4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

2590869:FJQ89 RS20520
gene id: 2590869:FJQ89_RS20520
uniprot id: A0A4Y6RJT0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

2590869:FJQ89 RS22240
gene id: 2590869:FJQ89_RS22240
uniprot id: A0A4Y6RKP2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

2590869:FJQ89 RS27035
gene id: 2590869:FJQ89_RS27035
uniprot id: A0A4Y6RKW6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

2590869:FJQ89 RS24170
gene id: 2590869:FJQ89_RS24170
uniprot id: A0A4Y6RJH4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

2590869:FJQ89 RS12335
gene id: 2590869:FJQ89_RS12335
uniprot id: A0A4Y6RDN4
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetyltransferase family. ArgA subfamily.
messages: Cytoplasm
messages: In bacteria which possess the bifunctional enzyme ornithine acetyltransferase/N-acetylglutamate synthase (ArgJ), ArgA fulfills an anaplerotic role.

2590869:FJQ89 RS10525
gene id: 2590869:FJQ89_RS10525
uniprot id: A0A4Y6RDZ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2590869:FJQ89 RS06375
gene id: 2590869:FJQ89_RS06375
uniprot id: A0A4Y6RAQ3
names: Similarity
messages: Belongs to the UPF0303 family.

2590869:FJQ89 RS20155
gene id: 2590869:FJQ89_RS20155
uniprot id: A0A4Y6RJ56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

2590869:FJQ89 RS02255
gene id: 2590869:FJQ89_RS02255
uniprot id: A0A4Y6R9U6
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

2590869:FJQ89 RS22635
gene id: 2590869:FJQ89_RS22635
uniprot id: A0A4Y6RK18
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsL family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Membrane
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

2590869:FJQ89 RS12105
gene id: 2590869:FJQ89_RS12105
uniprot id: A0A4Y6RDJ6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

2590869:FJQ89 RS09745
gene id: 2590869:FJQ89_RS09745
uniprot id: A0A4Y6RCN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

2590869:FJQ89 RS23200
gene id: 2590869:FJQ89_RS23200
uniprot id: A0A4Y6RKM8
names: Similarity
messages: Belongs to the intradiol ring-cleavage dioxygenase family.

2590869:FJQ89 RS08770
gene id: 2590869:FJQ89_RS08770
uniprot id: A0A4Y6RDC8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

2590869:FJQ89 RS16800
gene id: 2590869:FJQ89_RS16800
uniprot id: A0A4Y6RG44
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

2590869:FJQ89 RS07460
gene id: 2590869:FJQ89_RS07460
uniprot id: A0A4Y6RBD3
names: Subcellular Location Annotation
messages: Cytoplasm

2590869:FJQ89 RS20325
gene id: 2590869:FJQ89_RS20325
uniprot id: A0A4Y6RJF7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

2590869:FJQ89 RS13735
gene id: 2590869:FJQ89_RS13735
uniprot id: A0A4Y6RG50
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

2590869:FJQ89 RS21480
gene id: 2590869:FJQ89_RS21480
uniprot id: A0A4Y6RJE0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

2590869:FJQ89 RS11670
gene id: 2590869:FJQ89_RS11670
uniprot id: A0A4Y6REH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PriB family.
messages: Binds single-stranded DNA at the primosome assembly site (PAS).
messages: Component of the preprimosomal complex composed of PriA, PriB, PriC, DnaB and DnaT. Upon transient interaction with DnaG it forms the primosome.

2590869:FJQ89 RS02280
gene id: 2590869:FJQ89_RS02280
uniprot id: A0A4Y6RA30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

2590869:FJQ89 RS08875
gene id: 2590869:FJQ89_RS08875
uniprot id: A0A4Y6RC96
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

2590869:FJQ89 RS13110
gene id: 2590869:FJQ89_RS13110
uniprot id: A0A4Y6RG16
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

2590869:FJQ89 RS12590
gene id: 2590869:FJQ89_RS12590
uniprot id: A0A4Y6RE29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

2590869:FJQ89 RS11020
gene id: 2590869:FJQ89_RS11020
uniprot id: A0A4Y6RE64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

2590869:FJQ89 RS02285
gene id: 2590869:FJQ89_RS02285
uniprot id: A0A4Y6R8S7
names: Similarity
messages: Belongs to the ribosome association toxin RatA family.

2590869:FJQ89 RS14540
gene id: 2590869:FJQ89_RS14540
uniprot id: A0A4Y6RGB9
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.

2590869:FJQ89 RS25975
gene id: 2590869:FJQ89_RS25975
uniprot id: A0A4Y6RM39
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

2590869:FJQ89 RS07470
gene id: 2590869:FJQ89_RS07470
uniprot id: A0A4Y6RBK8
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

2590869:FJQ89 RS15810
gene id: 2590869:FJQ89_RS15810
uniprot id: A0A4Y6RFI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

2590869:FJQ89 RS09870
gene id: 2590869:FJQ89_RS09870
uniprot id: A0A4Y6RCP9
names: Similarity
messages: Belongs to the DEAD box helicase family.

2590869:FJQ89 RS14255
gene id: 2590869:FJQ89_RS14255
uniprot id: A0A4Y6RFQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

2590869:FJQ89 RS10480
gene id: 2590869:FJQ89_RS10480
uniprot id: A0A4Y6RED7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2590869:FJQ89 RS17865
gene id: 2590869:FJQ89_RS17865
uniprot id: A0A4Y6RMM9
names: Subcellular Location Annotation
messages: Membrane

2590869:FJQ89 RS01390
gene id: 2590869:FJQ89_RS01390
uniprot id: A0A4Y6R8C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2590869:FJQ89 RS02275
gene id: 2590869:FJQ89_RS02275
uniprot id: A0A4Y6R923
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone-like protein H-NS family.
messages: nucleoid

2590869:FJQ89 RS11195
gene id: 2590869:FJQ89_RS11195
uniprot id: A0A4Y6RD38
names: Similarity
messages: Belongs to the SdhE FAD assembly factor family.

2590869:FJQ89 RS25865
gene id: 2590869:FJQ89_RS25865
uniprot id: A0A4Y6RKA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbB/TolQ family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

2590869:FJQ89 RS17220
gene id: 2590869:FJQ89_RS17220
uniprot id: A0A4Y6RH91
names: Similarity
messages: Belongs to the GST superfamily.

2590869:FJQ89 RS20210
gene id: 2590869:FJQ89_RS20210
uniprot id: A0A4Y6RJ67
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

2590869:FJQ89 RS23565
gene id: 2590869:FJQ89_RS23565
uniprot id: A0A4Y6RJ61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

2590869:FJQ89 RS22690
gene id: 2590869:FJQ89_RS22690
uniprot id: A0A4Y6RK29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

2590869:FJQ89 RS10195
gene id: 2590869:FJQ89_RS10195
uniprot id: A0A4Y6RDS7
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

2590869:FJQ89 RS20220
gene id: 2590869:FJQ89_RS20220
uniprot id: A0A4Y6RHS1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

2590869:FJQ89 RS07815
gene id: 2590869:FJQ89_RS07815
uniprot id: A0A4Y6RCM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.
messages: Membrane

2590869:FJQ89 RS20290
gene id: 2590869:FJQ89_RS20290
uniprot id: A0A4Y6RHS6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

2590869:FJQ89 RS23695
gene id: 2590869:FJQ89_RS23695
uniprot id: A0A4Y6RJ84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0114 family.
messages: Cell membrane
messages: Membrane

2590869:FJQ89 RS20825
gene id: 2590869:FJQ89_RS20825
uniprot id: A0A4Y6RI14
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

2590869:FJQ89 RS22005
gene id: 2590869:FJQ89_RS22005
uniprot id: A0A4Y6RIL4
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

2590869:FJQ89 RS26840
gene id: 2590869:FJQ89_RS26840
uniprot id: A0A4Y6RN71
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

2590869:FJQ89 RS16415
gene id: 2590869:FJQ89_RS16415
uniprot id: A0A4Y6RFY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2590869:FJQ89 RS12805
gene id: 2590869:FJQ89_RS12805
uniprot id: A0A4Y6RE62
names: Similarity
messages: Belongs to the truncated hemoglobin family. Group II subfamily.

2590869:FJQ89 RS08820
gene id: 2590869:FJQ89_RS08820
uniprot id: A0A4Y6RDP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

2590869:FJQ89 RS23460
gene id: 2590869:FJQ89_RS23460
uniprot id: A0A4Y6RL12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

2590869:FJQ89 RS17670
gene id: 2590869:FJQ89_RS17670
uniprot id: A0A4Y6RIC5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2590869:FJQ89 RS03355
gene id: 2590869:FJQ89_RS03355
uniprot id: A0A4Y6RAP9
names: Subcellular Location Annotation
messages: Membrane

2590869:FJQ89 RS19980
gene id: 2590869:FJQ89_RS19980
uniprot id: A0A4Y6RJG1
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

2590869:FJQ89 RS19970
gene id: 2590869:FJQ89_RS19970
uniprot id: A0A4Y6RMG4
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2590869:FJQ89 RS18915
gene id: 2590869:FJQ89_RS18915
uniprot id: A0A4Y6RMT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

2590869:FJQ89 RS19060
gene id: 2590869:FJQ89_RS19060
uniprot id: A0A4Y6RIJ3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
messages: Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).
messages: The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
messages: The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

2590869:FJQ89 RS13135
gene id: 2590869:FJQ89_RS13135
uniprot id: A0A4Y6RFT9
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

2590869:FJQ89 RS03955
gene id: 2590869:FJQ89_RS03955
uniprot id: A0A4Y6R9P5
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

2590869:FJQ89 RS11240
gene id: 2590869:FJQ89_RS11240
uniprot id: A0A4Y6REQ9
names: Function
names: Similarity
messages: Belongs to the aconitase/IPM isomerase family.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.

2590869:FJQ89 RS18705
gene id: 2590869:FJQ89_RS18705
uniprot id: A0A4Y6RGR5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

2590869:FJQ89 RS27670
gene id: 2590869:FJQ89_RS27670
uniprot id: A0A4Y6RLC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

2590869:FJQ89 RS20310
gene id: 2590869:FJQ89_RS20310
uniprot id: A0A4Y6RJ87
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

2590869:FJQ89 RS27305
gene id: 2590869:FJQ89_RS27305
uniprot id: A0A4Y6RL11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2590869:FJQ89 RS17625
gene id: 2590869:FJQ89_RS17625
uniprot id: A0A4Y6RHE8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

2590869:FJQ89 RS04665
gene id: 2590869:FJQ89_RS04665
uniprot id: A0A4Y6RA69
names: Similarity
messages: Belongs to the thioesterase PaaI family.

2590869:FJQ89 RS16500
gene id: 2590869:FJQ89_RS16500
uniprot id: A0A4Y6RHU1
names: Function
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

2590869:FJQ89 RS26460
gene id: 2590869:FJQ89_RS26460
uniprot id: A0A4Y6RLY0
names: Similarity
messages: Belongs to the UPF0053 family.

2590869:FJQ89 RS23385
gene id: 2590869:FJQ89_RS23385
uniprot id: A0A4Y6RKT2
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

2590869:FJQ89 RS20300
gene id: 2590869:FJQ89_RS20300
uniprot id: A0A4Y6RJN2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

2590869:FJQ89 RS02690
gene id: 2590869:FJQ89_RS02690
uniprot id: A0A4Y6R8Z5
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

2590869:FJQ89 RS04460
gene id: 2590869:FJQ89_RS04460
uniprot id: A0A4Y6RA50
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

2590869:FJQ89 RS20250
gene id: 2590869:FJQ89_RS20250
uniprot id: A0A4Y6RJL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

2590869:FJQ89 RS09780
gene id: 2590869:FJQ89_RS09780
uniprot id: A0A4Y6RDT1
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

2590869:FJQ89 RS18600
gene id: 2590869:FJQ89_RS18600
uniprot id: A0A4Y6RIB8
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

2590869:FJQ89 RS23280
gene id: 2590869:FJQ89_RS23280
uniprot id: A0A4Y6RKR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

2590869:FJQ89 RS12565
gene id: 2590869:FJQ89_RS12565
uniprot id: A0A4Y6RDT3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell inner membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

2590869:FJQ89 RS21650
gene id: 2590869:FJQ89_RS21650
uniprot id: A0A4Y6RKC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiK family.
messages: Cytoplasm
messages: Required for efficient ubiquinone (coenzyme Q) biosynthesis. UbiK is probably an accessory factor of Ubi enzymes and facilitates ubiquinone biosynthesis by acting as an assembly factor, a targeting factor, or both.

2590869:FJQ89 RS02210
gene id: 2590869:FJQ89_RS02210
uniprot id: A0A4Y6RA68
names: Similarity
messages: Belongs to the skp family.

2590869:FJQ89 RS27055
gene id: 2590869:FJQ89_RS27055
uniprot id: A0A4Y6RL29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

2590869:FJQ89 RS05500
gene id: 2590869:FJQ89_RS05500
uniprot id: A0A4Y6RC89
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the quinolinate synthase family. Type 1 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
messages: Cytoplasm

2590869:FJQ89 RS27050
gene id: 2590869:FJQ89_RS27050
uniprot id: A0A4Y6RMV1
names: Similarity
messages: Belongs to the P(II) protein family.

2590869:FJQ89 RS13290
gene id: 2590869:FJQ89_RS13290
uniprot id: A0A4Y6RFR6
names: PTM
messages: Binds 1 heme c group covalently per subunit.

2590869:FJQ89 RS12570
gene id: 2590869:FJQ89_RS12570
uniprot id: A0A4Y6RE11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

2590869:FJQ89 RS02170
gene id: 2590869:FJQ89_RS02170
uniprot id: A0A4Y6R903
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

2590869:FJQ89 RS24920
gene id: 2590869:FJQ89_RS24920
uniprot id: A0A4Y6RM17
names: Similarity
messages: Belongs to the UPF0434 family.

2590869:FJQ89 RS14275
gene id: 2590869:FJQ89_RS14275
uniprot id: A0A4Y6REV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

2590869:FJQ89 RS16025
gene id: 2590869:FJQ89_RS16025
uniprot id: A0A4Y6RFG6
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

2590869:FJQ89 RS21785
gene id: 2590869:FJQ89_RS21785
uniprot id: A0A4Y6RK63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

2590869:FJQ89 RS17665
gene id: 2590869:FJQ89_RS17665
uniprot id: A0A4Y6RHV4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

2590869:FJQ89 RS12660
gene id: 2590869:FJQ89_RS12660
uniprot id: A0A4Y6RF00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

2590869:FJQ89 RS07490
gene id: 2590869:FJQ89_RS07490
uniprot id: A0A4Y6RCS9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

2590869:FJQ89 RS22890
gene id: 2590869:FJQ89_RS22890
uniprot id: A0A4Y6RIU9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
messages: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
messages: Homotetramer.

2590869:FJQ89 RS01680
gene id: 2590869:FJQ89_RS01680
uniprot id: A0A4Y6R8K6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

2590869:FJQ89 RS12455
gene id: 2590869:FJQ89_RS12455
uniprot id: A0A4Y6RDW4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

2590869:FJQ89 RS20235
gene id: 2590869:FJQ89_RS20235
uniprot id: A0A4Y6RHJ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

2590869:FJQ89 RS19150
gene id: 2590869:FJQ89_RS19150
uniprot id: A0A4Y6RH01
names: Function
names: Similarity
names: Subunit
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.
messages: Interacts with MinC and FtsZ.

2590869:FJQ89 RS19910
gene id: 2590869:FJQ89_RS19910
uniprot id: A0A4Y6RP73
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TtcA family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is chelated by three Cys residues, the fourth Fe has a free coordination site that may bind a sulfur atom transferred from the persulfide of IscS.
messages: Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
messages: Cytoplasm
messages: Homodimer.
messages: The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster.

2590869:FJQ89 RS16350
gene id: 2590869:FJQ89_RS16350
uniprot id: A0A4Y6RFP3
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

2590869:FJQ89 RS18735
gene id: 2590869:FJQ89_RS18735
uniprot id: A0A4Y6RID0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

2590869:FJQ89 RS11025
gene id: 2590869:FJQ89_RS11025
uniprot id: A0A4Y6REM1
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

2590869:FJQ89 RS15755
gene id: 2590869:FJQ89_RS15755
uniprot id: A0A4Y6RFK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

2590869:FJQ89 RS15735
gene id: 2590869:FJQ89_RS15735
uniprot id: A0A4Y6RFL9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

2590869:FJQ89 RS19960
gene id: 2590869:FJQ89_RS19960
uniprot id: A0A4Y6RHR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

2590869:FJQ89 RS20335
gene id: 2590869:FJQ89_RS20335
uniprot id: A0A4Y6RHL3
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

2590869:FJQ89 RS12760
gene id: 2590869:FJQ89_RS12760
uniprot id: A0A4Y6RFG8
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

2590869:FJQ89 RS09300
gene id: 2590869:FJQ89_RS09300
uniprot id: A0A4Y6RCH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2590869:FJQ89 RS22065
gene id: 2590869:FJQ89_RS22065
uniprot id: A0A4Y6RIP3
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

2590869:FJQ89 RS12875
gene id: 2590869:FJQ89_RS12875
uniprot id: A0A4Y6RFX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

2590869:FJQ89 RS11065
gene id: 2590869:FJQ89_RS11065
uniprot id: A0A4Y6RF09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

2590869:FJQ89 RS20170
gene id: 2590869:FJQ89_RS20170
uniprot id: A0A4Y6RJC4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

2590869:FJQ89 RS02810
gene id: 2590869:FJQ89_RS02810
uniprot id: A0A4Y6R9A8
names: Similarity
messages: Belongs to the universal stress protein A family.

2590869:FJQ89 RS21685
gene id: 2590869:FJQ89_RS21685
uniprot id: A0A4Y6RIF4
names: Subcellular Location Annotation
messages: Cytoplasm

2590869:FJQ89 RS11210
gene id: 2590869:FJQ89_RS11210
uniprot id: A0A4Y6RD79
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD.
messages: The heme is bound between the two transmembrane subunits.

2590869:FJQ89 RS16000
gene id: 2590869:FJQ89_RS16000
uniprot id: A0A4Y6RFQ4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Binds 1 nickel ion per subunit.
messages: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

2590869:FJQ89 RS22185
gene id: 2590869:FJQ89_RS22185
uniprot id: A0A4Y6RK62
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

2590869:FJQ89 RS11070
gene id: 2590869:FJQ89_RS11070
uniprot id: A0A4Y6RE77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

2590869:FJQ89 RS12345
gene id: 2590869:FJQ89_RS12345
uniprot id: A0A4Y6RFF1
names: Function
names: Similarity
messages: Belongs to the Fe(2+)-trafficking protein family.
messages: Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.

2590869:FJQ89 RS27875
gene id: 2590869:FJQ89_RS27875
uniprot id: A0A4Y6RN37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PstS family.
messages: Part of the ABC transporter complex PstSACB involved in phosphate import.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

2590869:FJQ89 RS22465
gene id: 2590869:FJQ89_RS22465
uniprot id: A0A4Y6RJZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

2590869:FJQ89 RS11650
gene id: 2590869:FJQ89_RS11650
uniprot id: A0A4Y6RDA5
names: Similarity
messages: Belongs to the UPF0111 family.

2590869:FJQ89 RS15415
gene id: 2590869:FJQ89_RS15415
uniprot id: A0A4Y6RH87
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2590869:FJQ89 RS27550
gene id: 2590869:FJQ89_RS27550
uniprot id: A0A4Y6RLG9
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

2590869:FJQ89 RS22075
gene id: 2590869:FJQ89_RS22075
uniprot id: A0A4Y6RKK5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

2590869:FJQ89 RS11710
gene id: 2590869:FJQ89_RS11710
uniprot id: A0A4Y6RDP2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

2590869:FJQ89 RS13040
gene id: 2590869:FJQ89_RS13040
uniprot id: A0A4Y6RE04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic sulfate-binding protein family.
messages: Periplasm

2590869:FJQ89 RS17085
gene id: 2590869:FJQ89_RS17085
uniprot id: A0A4Y6RG35
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

2590869:FJQ89 RS24375
gene id: 2590869:FJQ89_RS24375
uniprot id: A0A4Y6RJL0
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

2590869:FJQ89 RS05185
gene id: 2590869:FJQ89_RS05185
uniprot id: A0A4Y6RAL3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase bacterial subunit 4 family.
messages: Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
messages: Heterooctamer of two A chains, two B chains, two C chains and two D chains.
messages: Membrane

2590869:FJQ89 RS13275
gene id: 2590869:FJQ89_RS13275
uniprot id: A0A4Y6RFQ5
names: Similarity
messages: Belongs to the leucine-binding protein family.

2590869:FJQ89 RS13685
gene id: 2590869:FJQ89_RS13685
uniprot id: A0A4Y6RG41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

2590869:FJQ89 RS07455
gene id: 2590869:FJQ89_RS07455
uniprot id: A0A4Y6RD02
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

2590869:FJQ89 RS23500
gene id: 2590869:FJQ89_RS23500
uniprot id: A0A4Y6RJ52
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

2590869:FJQ89 RS10590
gene id: 2590869:FJQ89_RS10590
uniprot id: A0A4Y6RDZ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

2590869:FJQ89 RS18730
gene id: 2590869:FJQ89_RS18730
uniprot id: A0A4Y6RGZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

2590869:FJQ89 RS11655
gene id: 2590869:FJQ89_RS11655
uniprot id: A0A4Y6RDN2
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.

2590869:FJQ89 RS25425
gene id: 2590869:FJQ89_RS25425
uniprot id: A0A4Y6RLT0
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

2590869:FJQ89 RS20400
gene id: 2590869:FJQ89_RS20400
uniprot id: A0A4Y6RHV0
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the MsrP family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

2590869:FJQ89 RS08775
gene id: 2590869:FJQ89_RS08775
uniprot id: A0A4Y6RDX6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

2590869:FJQ89 RS14790
gene id: 2590869:FJQ89_RS14790
uniprot id: A0A4Y6RF46
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.

2590869:FJQ89 RS12650
gene id: 2590869:FJQ89_RS12650
uniprot id: A0A4Y6RFE7
names: Function
names: Similarity
messages: Belongs to the FlgD family.
messages: Required for flagellar hook formation. May act as a scaffolding protein.

2590869:FJQ89 RS23340
gene id: 2590869:FJQ89_RS23340
uniprot id: A0A4Y6RJ21
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

2590869:FJQ89 RS23625
gene id: 2590869:FJQ89_RS23625
uniprot id: A0A4Y6RJF9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

2590869:FJQ89 RS11690
gene id: 2590869:FJQ89_RS11690
uniprot id: A0A4Y6RDK7
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2590869:FJQ89 RS05690
gene id: 2590869:FJQ89_RS05690
uniprot id: A0A4Y6RAH0
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.

2590869:FJQ89 RS18645
gene id: 2590869:FJQ89_RS18645
uniprot id: A0A4Y6RHW5
names: Subcellular Location Annotation
messages: Membrane

2590869:FJQ89 RS02175
gene id: 2590869:FJQ89_RS02175
uniprot id: A0A4Y6RA12
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2590869:FJQ89 RS19995
gene id: 2590869:FJQ89_RS19995
uniprot id: A0A4Y6RHD8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

2590869:FJQ89 RS20205
gene id: 2590869:FJQ89_RS20205
uniprot id: A0A4Y6RIP8
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Methylated by PrmB.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

2590869:FJQ89 RS07745
gene id: 2590869:FJQ89_RS07745
uniprot id: A0A4Y6RBQ6
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2590869:FJQ89 RS25880
gene id: 2590869:FJQ89_RS25880
uniprot id: A0A4Y6RMI4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

2590869:FJQ89 RS19985
gene id: 2590869:FJQ89_RS19985
uniprot id: A0A4Y6RIK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

2590869:FJQ89 RS05445
gene id: 2590869:FJQ89_RS05445
uniprot id: A0A4Y6RBT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YciB family.
messages: Cell inner membrane
messages: Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.

2590869:FJQ89 RS23910
gene id: 2590869:FJQ89_RS23910
uniprot id: A0A4Y6RLH7
names: Subcellular Location Annotation
messages: Membrane

2590869:FJQ89 RS20315
gene id: 2590869:FJQ89_RS20315
uniprot id: A0A4Y6RHJ6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

2590869:FJQ89 RS10490
gene id: 2590869:FJQ89_RS10490
uniprot id: A0A4Y6RD13
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2590869:FJQ89 RS24950
gene id: 2590869:FJQ89_RS24950
uniprot id: A0A4Y6RK33
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

2590869:FJQ89 RS25490
gene id: 2590869:FJQ89_RS25490
uniprot id: A0A4Y6RKB3
names: Similarity
messages: Belongs to the UPF0234 family.

2590869:FJQ89 RS12670
gene id: 2590869:FJQ89_RS12670
uniprot id: A0A4Y6RDV3
names: Function
names: Similarity
messages: Belongs to the FlgM family.
messages: Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA.

2590869:FJQ89 RS17680
gene id: 2590869:FJQ89_RS17680
uniprot id: A0A4Y6RHX5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell inner membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

2590869:FJQ89 RS12340
gene id: 2590869:FJQ89_RS12340
uniprot id: A0A4Y6RDX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

2590869:FJQ89 RS16645
gene id: 2590869:FJQ89_RS16645
uniprot id: A0A4Y6RFU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

2590869:FJQ89 RS22080
gene id: 2590869:FJQ89_RS22080
uniprot id: A0A4Y6RJQ1
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

2590869:FJQ89 RS22655
gene id: 2590869:FJQ89_RS22655
uniprot id: A0A4Y6RKM0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane