2518644:EXN22 RS22450
gene id: 2518644:EXN22_RS22450
uniprot id: A0A411MNI6
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

2518644:EXN22 RS22840
gene id: 2518644:EXN22_RS22840
uniprot id: A0A411MNN4
names: Function
messages: Might be efficient in the degradation of transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions.

2518644:EXN22 RS20415
gene id: 2518644:EXN22_RS20415
uniprot id: A0A411MMA3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

2518644:EXN22 RS04450
gene id: 2518644:EXN22_RS04450
uniprot id: A0A411ME73
names: Similarity
messages: Belongs to the transcriptional regulatory Fis family.

2518644:EXN22 RS24730
gene id: 2518644:EXN22_RS24730
uniprot id: A0A411MPK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

2518644:EXN22 RS09965
gene id: 2518644:EXN22_RS09965
uniprot id: A0A411MH86
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD.
messages: The heme is bound between the two transmembrane subunits.

2518644:EXN22 RS24900
gene id: 2518644:EXN22_RS24900
uniprot id: A0A411MQ35
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

2518644:EXN22 RS19810
gene id: 2518644:EXN22_RS19810
uniprot id: A0A411MLW4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

2518644:EXN22 RS23645
gene id: 2518644:EXN22_RS23645
uniprot id: A0A411MP14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

2518644:EXN22 RS23905
gene id: 2518644:EXN22_RS23905
uniprot id: A0A411MP28
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

2518644:EXN22 RS10975
gene id: 2518644:EXN22_RS10975
uniprot id: A0A411MHB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

2518644:EXN22 RS22830
gene id: 2518644:EXN22_RS22830
uniprot id: A0A411MNI3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PAPS reductase family. CysD subfamily.
messages: Heterodimer composed of CysD, the smaller subunit, and CysN.
messages: With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

2518644:EXN22 RS24910
gene id: 2518644:EXN22_RS24910
uniprot id: A0A411MPK5
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

2518644:EXN22 RS09675
gene id: 2518644:EXN22_RS09675
uniprot id: A0A411MH07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

2518644:EXN22 RS07915
gene id: 2518644:EXN22_RS07915
uniprot id: A0A411MFN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Pal lipoprotein family.
messages: Cell outer membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

2518644:EXN22 RS02880
gene id: 2518644:EXN22_RS02880
uniprot id: A0A411MD05
names: Similarity
messages: Belongs to the YggT family.

2518644:EXN22 RS01080
gene id: 2518644:EXN22_RS01080
uniprot id: A0A411MCD4
names: Function
messages: This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.

2518644:EXN22 RS24785
gene id: 2518644:EXN22_RS24785
uniprot id: A0A411MPS9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

2518644:EXN22 RS06055
gene id: 2518644:EXN22_RS06055
uniprot id: A0A411MF18
names: Similarity
messages: Belongs to the HesB/IscA family.

2518644:EXN22 RS22525
gene id: 2518644:EXN22_RS22525
uniprot id: A0A411MNF4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

2518644:EXN22 RS05220
gene id: 2518644:EXN22_RS05220
uniprot id: A0A411MEA4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

2518644:EXN22 RS02610
gene id: 2518644:EXN22_RS02610
uniprot id: A0A411MQC2
names: Function
names: Similarity
messages: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
messages: Belongs to the Nudix hydrolase family. RppH subfamily.

2518644:EXN22 RS10065
gene id: 2518644:EXN22_RS10065
uniprot id: A0A411MGR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioester dehydratase family. FabA subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.

2518644:EXN22 RS23810
gene id: 2518644:EXN22_RS23810
uniprot id: A0A411MP55
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

2518644:EXN22 RS05345
gene id: 2518644:EXN22_RS05345
uniprot id: A0A411MEF9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

2518644:EXN22 RS01125
gene id: 2518644:EXN22_RS01125
uniprot id: A0A411MC25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PstS family.
messages: Involved in the system for phosphate transport across the cytoplasmic membrane.
messages: Periplasm
messages: Secreted

2518644:EXN22 RS24820
gene id: 2518644:EXN22_RS24820
uniprot id: A0A411MPG8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

2518644:EXN22 RS01535
gene id: 2518644:EXN22_RS01535
uniprot id: A0A411MC96
names: Subcellular Location Annotation
messages: Membrane

2518644:EXN22 RS23930
gene id: 2518644:EXN22_RS23930
uniprot id: A0A411MPI3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.

2518644:EXN22 RS22755
gene id: 2518644:EXN22_RS22755
uniprot id: A0A411MNH4
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

2518644:EXN22 RS00120
gene id: 2518644:EXN22_RS00120
uniprot id: A0A411MBI5
names: Cofactor
names: Similarity
messages: Belongs to the RimK family.
messages: Binds 2 magnesium or manganese ions per subunit.

2518644:EXN22 RS21570
gene id: 2518644:EXN22_RS21570
uniprot id: A0A411MMU2
names: Function
names: Similarity
messages: Belongs to the bacterioferritin family.
messages: Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.

2518644:EXN22 RS21305
gene id: 2518644:EXN22_RS21305
uniprot id: A0A411MMS1
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

2518644:EXN22 RS09995
gene id: 2518644:EXN22_RS09995
uniprot id: A0A411MGR3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

2518644:EXN22 RS24410
gene id: 2518644:EXN22_RS24410
uniprot id: A0A411MP93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

2518644:EXN22 RS24790
gene id: 2518644:EXN22_RS24790
uniprot id: A0A411MPP5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

2518644:EXN22 RS08875
gene id: 2518644:EXN22_RS08875
uniprot id: A0A411MG08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

2518644:EXN22 RS09910
gene id: 2518644:EXN22_RS09910
uniprot id: A0A411MH76
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

2518644:EXN22 RS23585
gene id: 2518644:EXN22_RS23585
uniprot id: A0A411MNX7
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

2518644:EXN22 RS24745
gene id: 2518644:EXN22_RS24745
uniprot id: A0A411MPJ9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

2518644:EXN22 RS19860
gene id: 2518644:EXN22_RS19860
uniprot id: A0A411MLX0
names: Similarity
messages: Belongs to the UPF0434 family.

2518644:EXN22 RS24540
gene id: 2518644:EXN22_RS24540
uniprot id: A0A411MPV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

2518644:EXN22 RS01655
gene id: 2518644:EXN22_RS01655
uniprot id: A0A411MCP4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

2518644:EXN22 RS03685
gene id: 2518644:EXN22_RS03685
uniprot id: A0A411MDD7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
messages: One is catalytic and the other provides a structural contribution.

2518644:EXN22 RS20625
gene id: 2518644:EXN22_RS20625
uniprot id: A0A411MMI7
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

2518644:EXN22 RS24485
gene id: 2518644:EXN22_RS24485
uniprot id: A0A411MPE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

2518644:EXN22 RS24875
gene id: 2518644:EXN22_RS24875
uniprot id: A0A411MPN0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

2518644:EXN22 RS05820
gene id: 2518644:EXN22_RS05820
uniprot id: A0A411MEK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Cell membrane
messages: Membrane

2518644:EXN22 RS24765
gene id: 2518644:EXN22_RS24765
uniprot id: A0A411MPL6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

2518644:EXN22 RS01520
gene id: 2518644:EXN22_RS01520
uniprot id: A0A411MC83
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Membrane

2518644:EXN22 RS05840
gene id: 2518644:EXN22_RS05840
uniprot id: A0A411MEF7
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
messages: Membrane

2518644:EXN22 RS01495
gene id: 2518644:EXN22_RS01495
uniprot id: A0A411MC89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

2518644:EXN22 RS21560
gene id: 2518644:EXN22_RS21560
uniprot id: A0A411MMV0
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

2518644:EXN22 RS02105
gene id: 2518644:EXN22_RS02105
uniprot id: A0A411MCL0
names: Function
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

2518644:EXN22 RS00990
gene id: 2518644:EXN22_RS00990
uniprot id: A0A411MBY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Cell membrane
messages: Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
messages: Membrane
messages: The accessory proteins ExbB and ExbD seem to form a complex with TonB.

2518644:EXN22 RS25910
gene id: 2518644:EXN22_RS25910
uniprot id: A0A411MQ70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

2518644:EXN22 RS25310
gene id: 2518644:EXN22_RS25310
uniprot id: A0A411MQR7
names: Function
names: Similarity
messages: Belongs to the PqqA family.
messages: Required for coenzyme pyrroloquinoline quinone (PQQ) biosynthesis. PQQ is probably formed by cross-linking a specific glutamate to a specific tyrosine residue and excising these residues from the peptide.

2518644:EXN22 RS01525
gene id: 2518644:EXN22_RS01525
uniprot id: A0A411MC77
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

2518644:EXN22 RS24295
gene id: 2518644:EXN22_RS24295
uniprot id: A0A411MP92
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

2518644:EXN22 RS17600
gene id: 2518644:EXN22_RS17600
uniprot id: A0A411MKQ9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

2518644:EXN22 RS01295
gene id: 2518644:EXN22_RS01295
uniprot id: A0A411MC78
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

2518644:EXN22 RS21555
gene id: 2518644:EXN22_RS21555
uniprot id: A0A411MMW7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase T family.
messages: Binds two Mg(2+) per subunit. The active form of the enzyme binds two Mg(2+) ions in its active site. The first Mg(2+) forms only one salt bridge with the protein.
messages: Homodimer.
messages: Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis.

2518644:EXN22 RS01050
gene id: 2518644:EXN22_RS01050
uniprot id: A0A411MBZ8
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.

2518644:EXN22 RS24810
gene id: 2518644:EXN22_RS24810
uniprot id: A0A411MPI2
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

2518644:EXN22 RS24815
gene id: 2518644:EXN22_RS24815
uniprot id: A0A411MPM4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

2518644:EXN22 RS07420
gene id: 2518644:EXN22_RS07420
uniprot id: A0A411MFC4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2518644:EXN22 RS24795
gene id: 2518644:EXN22_RS24795
uniprot id: A0A411MPL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

2518644:EXN22 RS24360
gene id: 2518644:EXN22_RS24360
uniprot id: A0A411MP83
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.

2518644:EXN22 RS03485
gene id: 2518644:EXN22_RS03485
uniprot id: A0A411MDP6
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

2518644:EXN22 RS21015
gene id: 2518644:EXN22_RS21015
uniprot id: A0A411MMH7
names: Similarity
messages: Belongs to the WrbA family.

2518644:EXN22 RS21575
gene id: 2518644:EXN22_RS21575
uniprot id: A0A411MMU4
names: Similarity
messages: Belongs to the glutaredoxin family. Monothiol subfamily.

2518644:EXN22 RS02830
gene id: 2518644:EXN22_RS02830
uniprot id: A0A411MCZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0382 family.
messages: Membrane

2518644:EXN22 RS21485
gene id: 2518644:EXN22_RS21485
uniprot id: A0A411MMQ9
names: Subcellular Location Annotation
messages: Cytoplasm

2518644:EXN22 RS03475
gene id: 2518644:EXN22_RS03475
uniprot id: A0A411MDC6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

2518644:EXN22 RS20045
gene id: 2518644:EXN22_RS20045
uniprot id: A0A411MMG0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2518644:EXN22 RS20265
gene id: 2518644:EXN22_RS20265
uniprot id: A0A411MM74
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

2518644:EXN22 RS11100
gene id: 2518644:EXN22_RS11100
uniprot id: A0A411MH73
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

2518644:EXN22 RS20760
gene id: 2518644:EXN22_RS20760
uniprot id: A0A411MMC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RdgC family.
messages: May be involved in recombination.
messages: nucleoid

2518644:EXN22 RS04480
gene id: 2518644:EXN22_RS04480
uniprot id: A0A411MDQ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

2518644:EXN22 RS19650
gene id: 2518644:EXN22_RS19650
uniprot id: A0A411MM17
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

2518644:EXN22 RS15985
gene id: 2518644:EXN22_RS15985
uniprot id: A0A411MK02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

2518644:EXN22 RS05210
gene id: 2518644:EXN22_RS05210
uniprot id: A0A411MEI6
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

2518644:EXN22 RS21885
gene id: 2518644:EXN22_RS21885
uniprot id: A0A411MN70
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

2518644:EXN22 RS21900
gene id: 2518644:EXN22_RS21900
uniprot id: A0A411MNG5
names: Function
names: Similarity
messages: An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.
messages: Belongs to the SdhE FAD assembly factor family.

2518644:EXN22 RS07840
gene id: 2518644:EXN22_RS07840
uniprot id: A0A411MFG8
names: Similarity
messages: Belongs to the SlyX family.

2518644:EXN22 RS01170
gene id: 2518644:EXN22_RS01170
uniprot id: A0A411MC10
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

2518644:EXN22 RS09580
gene id: 2518644:EXN22_RS09580
uniprot id: A0A411MGK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ureidoglycolate lyase family.
messages: Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source.
messages: Homodimer.

2518644:EXN22 RS10970
gene id: 2518644:EXN22_RS10970
uniprot id: A0A411MHL4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2518644:EXN22 RS10000
gene id: 2518644:EXN22_RS10000
uniprot id: A0A411MGM6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

2518644:EXN22 RS24770
gene id: 2518644:EXN22_RS24770
uniprot id: A0A411MPF9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

2518644:EXN22 RS17625
gene id: 2518644:EXN22_RS17625
uniprot id: A0A411MKW9
names: Subcellular Location Annotation
messages: Cytoplasm

2518644:EXN22 RS06495
gene id: 2518644:EXN22_RS06495
uniprot id: A0A411MEZ1
names: Similarity
messages: Belongs to the BolA/IbaG family.

2518644:EXN22 RS01690
gene id: 2518644:EXN22_RS01690
uniprot id: A0A411MCC8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

2518644:EXN22 RS18460
gene id: 2518644:EXN22_RS18460
uniprot id: A0A411MLC5
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

2518644:EXN22 RS00870
gene id: 2518644:EXN22_RS00870
uniprot id: A0A411MBW9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

2518644:EXN22 RS24830
gene id: 2518644:EXN22_RS24830
uniprot id: A0A411MPM3
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

2518644:EXN22 RS24760
gene id: 2518644:EXN22_RS24760
uniprot id: A0A411MPH2
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

2518644:EXN22 RS25235
gene id: 2518644:EXN22_RS25235
uniprot id: A0A411MPV1
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

2518644:EXN22 RS07575
gene id: 2518644:EXN22_RS07575
uniprot id: A0A411MFI1
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

2518644:EXN22 RS21880
gene id: 2518644:EXN22_RS21880
uniprot id: A0A411MN04
names: Similarity
messages: Belongs to the RseA family.

2518644:EXN22 RS04000
gene id: 2518644:EXN22_RS04000
uniprot id: A0A411MQH4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

2518644:EXN22 RS06600
gene id: 2518644:EXN22_RS06600
uniprot id: A0A411MEY9
names: Subcellular Location Annotation
messages: Cytoplasm

2518644:EXN22 RS00710
gene id: 2518644:EXN22_RS00710
uniprot id: A0A411MBS4
names: Similarity
messages: Belongs to the P(II) protein family.

2518644:EXN22 RS00910
gene id: 2518644:EXN22_RS00910
uniprot id: A0A411MBX9
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

2518644:EXN22 RS19615
gene id: 2518644:EXN22_RS19615
uniprot id: A0A411MLU2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2518644:EXN22 RS00810
gene id: 2518644:EXN22_RS00810
uniprot id: A0A411MBW5
names: Function
names: Similarity
messages: Belongs to the DadA oxidoreductase family.
messages: Oxidative deamination of D-amino acids.

2518644:EXN22 RS09205
gene id: 2518644:EXN22_RS09205
uniprot id: A0A411MG69
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

2518644:EXN22 RS24855
gene id: 2518644:EXN22_RS24855
uniprot id: A0A411MPR1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

2518644:EXN22 RS24870
gene id: 2518644:EXN22_RS24870
uniprot id: A0A411MPI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

2518644:EXN22 RS11090
gene id: 2518644:EXN22_RS11090
uniprot id: A0A411MHD0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

2518644:EXN22 RS06080
gene id: 2518644:EXN22_RS06080
uniprot id: A0A411MEZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

2518644:EXN22 RS07030
gene id: 2518644:EXN22_RS07030
uniprot id: A0A411MF59
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

2518644:EXN22 RS01530
gene id: 2518644:EXN22_RS01530
uniprot id: A0A411MC94
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

2518644:EXN22 RS03375
gene id: 2518644:EXN22_RS03375
uniprot id: A0A411MQD5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

2518644:EXN22 RS24750
gene id: 2518644:EXN22_RS24750
uniprot id: A0A411MPZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

2518644:EXN22 RS24805
gene id: 2518644:EXN22_RS24805
uniprot id: A0A411MPP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

2518644:EXN22 RS04115
gene id: 2518644:EXN22_RS04115
uniprot id: A0A411MDN0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

2518644:EXN22 RS09975
gene id: 2518644:EXN22_RS09975
uniprot id: A0A411MGS0
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

2518644:EXN22 RS02455
gene id: 2518644:EXN22_RS02455
uniprot id: A0A411MD17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

2518644:EXN22 RS24845
gene id: 2518644:EXN22_RS24845
uniprot id: A0A411MPN2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

2518644:EXN22 RS12400
gene id: 2518644:EXN22_RS12400
uniprot id: A0A411MIB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

2518644:EXN22 RS08935
gene id: 2518644:EXN22_RS08935
uniprot id: A0A411MGL4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

2518644:EXN22 RS22760
gene id: 2518644:EXN22_RS22760
uniprot id: A0A411MNP1
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

2518644:EXN22 RS24905
gene id: 2518644:EXN22_RS24905
uniprot id: A0A411MPS7
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

2518644:EXN22 RS01505
gene id: 2518644:EXN22_RS01505
uniprot id: A0A411MCL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

2518644:EXN22 RS06450
gene id: 2518644:EXN22_RS06450
uniprot id: A0A411MEW1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LptA family.
messages: Component of the lipopolysaccharide transport and assembly complex.
messages: Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.
messages: Periplasm

2518644:EXN22 RS06050
gene id: 2518644:EXN22_RS06050
uniprot id: A0A411MEM2
names: Function
names: Similarity
messages: A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
messages: Belongs to the NifU family.

2518644:EXN22 RS19790
gene id: 2518644:EXN22_RS19790
uniprot id: A0A411MLW6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

2518644:EXN22 RS06005
gene id: 2518644:EXN22_RS06005
uniprot id: A0A411MF08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane

2518644:EXN22 RS00485
gene id: 2518644:EXN22_RS00485
uniprot id: A0A411MBQ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.

2518644:EXN22 RS07455
gene id: 2518644:EXN22_RS07455
uniprot id: A0A411MFA0
names: Similarity
messages: Belongs to the Skp family.

2518644:EXN22 RS00865
gene id: 2518644:EXN22_RS00865
uniprot id: A0A411MBV4
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

2518644:EXN22 RS23445
gene id: 2518644:EXN22_RS23445
uniprot id: A0A411MNZ6
names: Subcellular Location Annotation
messages: Membrane

2518644:EXN22 RS18170
gene id: 2518644:EXN22_RS18170
uniprot id: A0A411ML41
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

2518644:EXN22 RS21480
gene id: 2518644:EXN22_RS21480
uniprot id: A0A411MMU7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2518644:EXN22 RS03965
gene id: 2518644:EXN22_RS03965
uniprot id: A0A411MDG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

2518644:EXN22 RS22795
gene id: 2518644:EXN22_RS22795
uniprot id: A0A411MNK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZapG family.
messages: Cell inner membrane
messages: Membrane

2518644:EXN22 RS06340
gene id: 2518644:EXN22_RS06340
uniprot id: A0A411MEW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

2518644:EXN22 RS09215
gene id: 2518644:EXN22_RS09215
uniprot id: A0A411MGR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Cell inner membrane
messages: FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

2518644:EXN22 RS11005
gene id: 2518644:EXN22_RS11005
uniprot id: A0A411MHA6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2518644:EXN22 RS24725
gene id: 2518644:EXN22_RS24725
uniprot id: A0A411MPJ5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

2518644:EXN22 RS09080
gene id: 2518644:EXN22_RS09080
uniprot id: A0A411MG78
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

2518644:EXN22 RS23655
gene id: 2518644:EXN22_RS23655
uniprot id: A0A411MPC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

2518644:EXN22 RS10965
gene id: 2518644:EXN22_RS10965
uniprot id: A0A411MHR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: Composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2518644:EXN22 RS24720
gene id: 2518644:EXN22_RS24720
uniprot id: A0A411MPE8
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

2518644:EXN22 RS19145
gene id: 2518644:EXN22_RS19145
uniprot id: A0A411MLP7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribosome modulation factor family.
messages: Cytoplasm
messages: During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes).

2518644:EXN22 RS01580
gene id: 2518644:EXN22_RS01580
uniprot id: A0A411MCA6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

2518644:EXN22 RS07895
gene id: 2518644:EXN22_RS07895
uniprot id: A0A411MFI2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbB/TolQ family.
messages: Cell inner membrane
messages: Membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

2518644:EXN22 RS02805
gene id: 2518644:EXN22_RS02805
uniprot id: A0A411MCY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.

2518644:EXN22 RS06545
gene id: 2518644:EXN22_RS06545
uniprot id: A0A411MF01
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.

2518644:EXN22 RS22695
gene id: 2518644:EXN22_RS22695
uniprot id: A0A411MNG8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

2518644:EXN22 RS09280
gene id: 2518644:EXN22_RS09280
uniprot id: A0A411MGE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

2518644:EXN22 RS10620
gene id: 2518644:EXN22_RS10620
uniprot id: A0A411MH18
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

2518644:EXN22 RS24800
gene id: 2518644:EXN22_RS24800
uniprot id: A0A411MQ11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

2518644:EXN22 RS08865
gene id: 2518644:EXN22_RS08865
uniprot id: A0A411MGG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane

2518644:EXN22 RS04125
gene id: 2518644:EXN22_RS04125
uniprot id: A0A411ME12
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

2518644:EXN22 RS03495
gene id: 2518644:EXN22_RS03495
uniprot id: A0A411MDB8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

2518644:EXN22 RS08450
gene id: 2518644:EXN22_RS08450
uniprot id: A0A411MFU0
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

2518644:EXN22 RS03835
gene id: 2518644:EXN22_RS03835
uniprot id: A0A411MDK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

2518644:EXN22 RS00780
gene id: 2518644:EXN22_RS00780
uniprot id: A0A411MBW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
messages: Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
messages: Cytoplasm
messages: Homodimer.

2518644:EXN22 RS07515
gene id: 2518644:EXN22_RS07515
uniprot id: A0A411MFT3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsB family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

2518644:EXN22 RS24835
gene id: 2518644:EXN22_RS24835
uniprot id: A0A411MPU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

2518644:EXN22 RS21460
gene id: 2518644:EXN22_RS21460
uniprot id: A0A411MMT0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.
messages: Cell membrane

2518644:EXN22 RS01060
gene id: 2518644:EXN22_RS01060
uniprot id: A0A411MC09
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Cytoplasm

2518644:EXN22 RS24735
gene id: 2518644:EXN22_RS24735
uniprot id: A0A411MPR4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

2518644:EXN22 RS06160
gene id: 2518644:EXN22_RS06160
uniprot id: A0A411MEW3
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

2518644:EXN22 RS22365
gene id: 2518644:EXN22_RS22365
uniprot id: A0A411MNQ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Catalyzes the reversible hydration of fumarate to (S)-malate.
messages: Homodimer.

2518644:EXN22 RS07040
gene id: 2518644:EXN22_RS07040
uniprot id: A0A411MFD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

2518644:EXN22 RS05185
gene id: 2518644:EXN22_RS05185
uniprot id: A0A411MEK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0114 family.
messages: Cell membrane
messages: Membrane

2518644:EXN22 RS07755
gene id: 2518644:EXN22_RS07755
uniprot id: A0A411MFJ0
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

2518644:EXN22 RS24825
gene id: 2518644:EXN22_RS24825
uniprot id: A0A411MPL7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.