2505979:EPZ47 RS01605
gene id: 2505979:EPZ47_RS01605
uniprot id: A0A4P7PAT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

2505979:EPZ47 RS25525
gene id: 2505979:EPZ47_RS25525
uniprot id: A0A4P7PM05
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

2505979:EPZ47 RS05920
gene id: 2505979:EPZ47_RS05920
uniprot id: A0A4P7PCJ8
names: Function
messages: Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.

2505979:EPZ47 RS09315
gene id: 2505979:EPZ47_RS09315
uniprot id: A0A4P7PFE8
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

2505979:EPZ47 RS04115
gene id: 2505979:EPZ47_RS04115
uniprot id: A0A4P7PBZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

2505979:EPZ47 RS29410
gene id: 2505979:EPZ47_RS29410
uniprot id: A0A4P7PNW8
names: Function
messages: This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.

2505979:EPZ47 RS26710
gene id: 2505979:EPZ47_RS26710
uniprot id: A0A4P7PN38
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

2505979:EPZ47 RS07545
gene id: 2505979:EPZ47_RS07545
uniprot id: A0A4P7PDI7
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

2505979:EPZ47 RS02095
gene id: 2505979:EPZ47_RS02095
uniprot id: A0A4P7PAV8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2505979:EPZ47 RS05410
gene id: 2505979:EPZ47_RS05410
uniprot id: A0A4P7PCC4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

2505979:EPZ47 RS26845
gene id: 2505979:EPZ47_RS26845
uniprot id: A0A4P7PNN2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2505979:EPZ47 RS28960
gene id: 2505979:EPZ47_RS28960
uniprot id: A0A4P7PPM3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

2505979:EPZ47 RS29290
gene id: 2505979:EPZ47_RS29290
uniprot id: A0A4P7PPB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ElaB/YgaM/YqjD family.
messages: Cell inner membrane
messages: Membrane

2505979:EPZ47 RS22815
gene id: 2505979:EPZ47_RS22815
uniprot id: A0A4P7PL70
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

2505979:EPZ47 RS26475
gene id: 2505979:EPZ47_RS26475
uniprot id: A0A4P7PMH2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
messages: Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers.

2505979:EPZ47 RS05865
gene id: 2505979:EPZ47_RS05865
uniprot id: A0A4P7PCM5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsB family.
messages: Cell inner membrane
messages: Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
messages: Part of a complex composed of FtsB, FtsL and FtsQ.

2505979:EPZ47 RS26380
gene id: 2505979:EPZ47_RS26380
uniprot id: A0A4P7PMA5
names: Similarity
messages: Belongs to the PspA/IM30 family.

2505979:EPZ47 RS08000
gene id: 2505979:EPZ47_RS08000
uniprot id: A0A4P7PDJ3
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

2505979:EPZ47 RS24250
gene id: 2505979:EPZ47_RS24250
uniprot id: A0A4P7PLB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

2505979:EPZ47 RS09130
gene id: 2505979:EPZ47_RS09130
uniprot id: A0A4P7PE37
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Cell inner membrane
messages: Homoheptamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.

2505979:EPZ47 RS20970
gene id: 2505979:EPZ47_RS20970
uniprot id: A0A4P7PJV7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

2505979:EPZ47 RS20990
gene id: 2505979:EPZ47_RS20990
uniprot id: A0A4P7PL84
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

2505979:EPZ47 RS22625
gene id: 2505979:EPZ47_RS22625
uniprot id: A0A4P7PKM5
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TtcA family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is chelated by three Cys residues, the fourth Fe has a free coordination site that may bind a sulfur atom transferred from the persulfide of IscS.
messages: Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
messages: Cytoplasm
messages: Homodimer.
messages: The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster.

2505979:EPZ47 RS23385
gene id: 2505979:EPZ47_RS23385
uniprot id: A0A4P7PKW1
names: Subcellular Location Annotation
messages: Cytoplasm

2505979:EPZ47 RS25130
gene id: 2505979:EPZ47_RS25130
uniprot id: A0A4P7PLQ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

2505979:EPZ47 RS29390
gene id: 2505979:EPZ47_RS29390
uniprot id: A0A4P7PPC8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Cytoplasm

2505979:EPZ47 RS23515
gene id: 2505979:EPZ47_RS23515
uniprot id: A0A4P7PKV8
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

2505979:EPZ47 RS01995
gene id: 2505979:EPZ47_RS01995
uniprot id: A0A4P7PAS9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

2505979:EPZ47 RS02705
gene id: 2505979:EPZ47_RS02705
uniprot id: A0A4P7PBJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Hfq family.
messages: Homohexamer.
messages: RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.

2505979:EPZ47 RS20525
gene id: 2505979:EPZ47_RS20525
uniprot id: A0A4P7PJW2
names: Function
names: Similarity
messages: Belongs to the DUF177 domain family.
messages: Plays a role in synthesis, processing and/or stability of 23S rRNA.

2505979:EPZ47 RS26670
gene id: 2505979:EPZ47_RS26670
uniprot id: A0A4P7PMI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

2505979:EPZ47 RS26665
gene id: 2505979:EPZ47_RS26665
uniprot id: A0A4P7PMY6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

2505979:EPZ47 RS20590
gene id: 2505979:EPZ47_RS20590
uniprot id: A0A4P7PJQ0
names: Similarity
messages: Belongs to the UPF0434 family.

2505979:EPZ47 RS00055
gene id: 2505979:EPZ47_RS00055
uniprot id: A0A4P7P9P7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

2505979:EPZ47 RS06290
gene id: 2505979:EPZ47_RS06290
uniprot id: A0A4P7PCU0
names: Subcellular Location Annotation
messages: Cytoplasm

2505979:EPZ47 RS21820
gene id: 2505979:EPZ47_RS21820
uniprot id: A0A4P7PKL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioredoxin family. DsbE subfamily.
messages: Cell inner membrane

2505979:EPZ47 RS04130
gene id: 2505979:EPZ47_RS04130
uniprot id: A0A4P7PBX1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

2505979:EPZ47 RS05890
gene id: 2505979:EPZ47_RS05890
uniprot id: A0A4V1CAA8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).

2505979:EPZ47 RS08060
gene id: 2505979:EPZ47_RS08060
uniprot id: A0A4P7PEY6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliN/MopA/SpaO family.
messages: Cell membrane
messages: FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

2505979:EPZ47 RS04125
gene id: 2505979:EPZ47_RS04125
uniprot id: A0A4P7PBU0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

2505979:EPZ47 RS23485
gene id: 2505979:EPZ47_RS23485
uniprot id: A0A4P7PLZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Pal lipoprotein family.
messages: Cell outer membrane
messages: Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
messages: The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.

2505979:EPZ47 RS29495
gene id: 2505979:EPZ47_RS29495
uniprot id: A0A4P7PPE1
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

2505979:EPZ47 RS26805
gene id: 2505979:EPZ47_RS26805
uniprot id: A0A4V1CBE8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

2505979:EPZ47 RS00235
gene id: 2505979:EPZ47_RS00235
uniprot id: A0A4P7PAE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0391 family.
messages: Cell membrane

2505979:EPZ47 RS29860
gene id: 2505979:EPZ47_RS29860
uniprot id: A0A4P7PPF3
names: Function
names: Similarity
messages: Belongs to the ParB family.
messages: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.

2505979:EPZ47 RS05760
gene id: 2505979:EPZ47_RS05760
uniprot id: A0A4P7PCI6
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

2505979:EPZ47 RS09695
gene id: 2505979:EPZ47_RS09695
uniprot id: A0A4P7PEK4
names: Similarity
messages: Belongs to the FrmR/RcnR family.

2505979:EPZ47 RS05185
gene id: 2505979:EPZ47_RS05185
uniprot id: A0A4P7PCB1
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

2505979:EPZ47 RS01090
gene id: 2505979:EPZ47_RS01090
uniprot id: A0A4P7PAH7
names: Function
names: Similarity
messages: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
messages: Belongs to the Nudix hydrolase family. RppH subfamily.

2505979:EPZ47 RS18250
gene id: 2505979:EPZ47_RS18250
uniprot id: A0A4P7PIG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

2505979:EPZ47 RS28105
gene id: 2505979:EPZ47_RS28105
uniprot id: A0A4P7PN01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0382 family.
messages: Membrane

2505979:EPZ47 RS26835
gene id: 2505979:EPZ47_RS26835
uniprot id: A0A4P7PMJ1
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

2505979:EPZ47 RS05245
gene id: 2505979:EPZ47_RS05245
uniprot id: A0A4P7PCD9
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.

2505979:EPZ47 RS18255
gene id: 2505979:EPZ47_RS18255
uniprot id: A0A4P7PIH9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2505979:EPZ47 RS26800
gene id: 2505979:EPZ47_RS26800
uniprot id: A0A4P7PP11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

2505979:EPZ47 RS27130
gene id: 2505979:EPZ47_RS27130
uniprot id: A0A4P7PN54
names: Similarity
messages: Belongs to the UPF0229 family.

2505979:EPZ47 RS26420
gene id: 2505979:EPZ47_RS26420
uniprot id: A0A4P7PM89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

2505979:EPZ47 RS18140
gene id: 2505979:EPZ47_RS18140
uniprot id: A0A4P7PIS3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

2505979:EPZ47 RS20345
gene id: 2505979:EPZ47_RS20345
uniprot id: A0A4P7PJD8
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

2505979:EPZ47 RS21835
gene id: 2505979:EPZ47_RS21835
uniprot id: A0A4P7PKA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmD/CycX/HelD family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

2505979:EPZ47 RS23520
gene id: 2505979:EPZ47_RS23520
uniprot id: A0A4P7PL13
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

2505979:EPZ47 RS25855
gene id: 2505979:EPZ47_RS25855
uniprot id: A0A4P7PLZ2
names: Similarity
messages: Belongs to the outer membrane porin (Opr) (TC 1.B.25) family.

2505979:EPZ47 RS09320
gene id: 2505979:EPZ47_RS09320
uniprot id: A0A4P7PFH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

2505979:EPZ47 RS21540
gene id: 2505979:EPZ47_RS21540
uniprot id: A0A4P7PKG5
names: Function
names: Similarity
names: Subunit
messages: ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.
messages: Belongs to the ParA family. MinD subfamily.
messages: Interacts with MinC and FtsZ.

2505979:EPZ47 RS29465
gene id: 2505979:EPZ47_RS29465
uniprot id: A0A4P7PNR1
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

2505979:EPZ47 RS29815
gene id: 2505979:EPZ47_RS29815
uniprot id: A0A4P7PNZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

2505979:EPZ47 RS27935
gene id: 2505979:EPZ47_RS27935
uniprot id: A0A4P7PMX8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MdcC family.
messages: Covalently binds the prosthetic group of malonate decarboxylase.
messages: Cytoplasm
messages: Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism.

2505979:EPZ47 RS24780
gene id: 2505979:EPZ47_RS24780
uniprot id: A0A4P7PLH4
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

2505979:EPZ47 RS26130
gene id: 2505979:EPZ47_RS26130
uniprot id: A0A4P7PM57
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

2505979:EPZ47 RS20905
gene id: 2505979:EPZ47_RS20905
uniprot id: A0A4P7PK52
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thioester dehydratase family. FabA subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.

2505979:EPZ47 RS26020
gene id: 2505979:EPZ47_RS26020
uniprot id: A0A4P7PM90
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

2505979:EPZ47 RS28010
gene id: 2505979:EPZ47_RS28010
uniprot id: A0A4P7PP71
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

2505979:EPZ47 RS08110
gene id: 2505979:EPZ47_RS08110
uniprot id: A0A4P7PEZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sigma-70 factor family. FliA subfamily.
messages: Cytoplasm
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes.

2505979:EPZ47 RS19010
gene id: 2505979:EPZ47_RS19010
uniprot id: A0A4V1CB04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

2505979:EPZ47 RS10355
gene id: 2505979:EPZ47_RS10355
uniprot id: A0A4P7PEP3
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit A family.

2505979:EPZ47 RS26700
gene id: 2505979:EPZ47_RS26700
uniprot id: A0A4P7PNZ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

2505979:EPZ47 RS29035
gene id: 2505979:EPZ47_RS29035
uniprot id: A0A4P7PNL1
names: Similarity
messages: Belongs to the RutC family.

2505979:EPZ47 RS18280
gene id: 2505979:EPZ47_RS18280
uniprot id: A0A4P7PJU2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2505979:EPZ47 RS21160
gene id: 2505979:EPZ47_RS21160
uniprot id: A0A4P7PKA6
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.
messages: Methylates ribosomal protein uL3 on a specific glutamine residue.

2505979:EPZ47 RS28580
gene id: 2505979:EPZ47_RS28580
uniprot id: A0A4P7PN86
names: Similarity
messages: Belongs to the thioredoxin family.

2505979:EPZ47 RS26705
gene id: 2505979:EPZ47_RS26705
uniprot id: A0A4V1CBE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

2505979:EPZ47 RS09175
gene id: 2505979:EPZ47_RS09175
uniprot id: A0A4P7PEL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.
messages: Cell membrane
messages: Membrane

2505979:EPZ47 RS05260
gene id: 2505979:EPZ47_RS05260
uniprot id: A0A4P7PDG6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

2505979:EPZ47 RS25400
gene id: 2505979:EPZ47_RS25400
uniprot id: A0A4P7PME6
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

2505979:EPZ47 RS09515
gene id: 2505979:EPZ47_RS09515
uniprot id: A0A4P7PFI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

2505979:EPZ47 RS23140
gene id: 2505979:EPZ47_RS23140
uniprot id: A0A4P7PKP9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

2505979:EPZ47 RS23525
gene id: 2505979:EPZ47_RS23525
uniprot id: A0A4P7PKW5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

2505979:EPZ47 RS05405
gene id: 2505979:EPZ47_RS05405
uniprot id: A0A4P7PCF8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

2505979:EPZ47 RS05420
gene id: 2505979:EPZ47_RS05420
uniprot id: A0A4P7PDJ6
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

2505979:EPZ47 RS00810
gene id: 2505979:EPZ47_RS00810
uniprot id: A0A4P7PAE3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.
messages: Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).

2505979:EPZ47 RS18110
gene id: 2505979:EPZ47_RS18110
uniprot id: A0A4P7PIF3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

2505979:EPZ47 RS06540
gene id: 2505979:EPZ47_RS06540
uniprot id: A0A4P7PD18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

2505979:EPZ47 RS20965
gene id: 2505979:EPZ47_RS20965
uniprot id: A0A4P7PJQ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

2505979:EPZ47 RS04215
gene id: 2505979:EPZ47_RS04215
uniprot id: A0A4P7PD60
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

2505979:EPZ47 RS25670
gene id: 2505979:EPZ47_RS25670
uniprot id: A0A4P7PMI8
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

2505979:EPZ47 RS01145
gene id: 2505979:EPZ47_RS01145
uniprot id: A0A4P7PAC0
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

2505979:EPZ47 RS08165
gene id: 2505979:EPZ47_RS08165
uniprot id: A0A4V1CAF1
names: Similarity
messages: Belongs to the type III secretion exporter family.

2505979:EPZ47 RS27745
gene id: 2505979:EPZ47_RS27745
uniprot id: A0A4P7PMY0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
messages: One is catalytic and the other provides a structural contribution.

2505979:EPZ47 RS26730
gene id: 2505979:EPZ47_RS26730
uniprot id: A0A4P7PML6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

2505979:EPZ47 RS26715
gene id: 2505979:EPZ47_RS26715
uniprot id: A0A4P7PMZ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

2505979:EPZ47 RS20520
gene id: 2505979:EPZ47_RS20520
uniprot id: A0A4P7PK42
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

2505979:EPZ47 RS26815
gene id: 2505979:EPZ47_RS26815
uniprot id: A0A4P7PN12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

2505979:EPZ47 RS29030
gene id: 2505979:EPZ47_RS29030
uniprot id: A0A4P7PP24
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

2505979:EPZ47 RS08715
gene id: 2505979:EPZ47_RS08715
uniprot id: A0A4P7PE13
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

2505979:EPZ47 RS09030
gene id: 2505979:EPZ47_RS09030
uniprot id: A0A4P7PE19
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

2505979:EPZ47 RS26695
gene id: 2505979:EPZ47_RS26695
uniprot id: A0A4P7PNK4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

2505979:EPZ47 RS23135
gene id: 2505979:EPZ47_RS23135
uniprot id: A0A4P7PKR6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

2505979:EPZ47 RS26785
gene id: 2505979:EPZ47_RS26785
uniprot id: A0A4P7PMH8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

2505979:EPZ47 RS18740
gene id: 2505979:EPZ47_RS18740
uniprot id: A0A4P7PJD8
names: Similarity
messages: Belongs to the ETF beta-subunit/FixA family.

2505979:EPZ47 RS01300
gene id: 2505979:EPZ47_RS01300
uniprot id: A0A4P7PAG6
names: Cofactor
names: Similarity
messages: Belongs to the RimK family.
messages: Binds 2 magnesium or manganese ions per subunit.

2505979:EPZ47 RS08255
gene id: 2505979:EPZ47_RS08255
uniprot id: A0A4P7PEV9
names: Similarity
messages: Belongs to the UPF0270 family.

2505979:EPZ47 RS02770
gene id: 2505979:EPZ47_RS02770
uniprot id: A0A4P7PBK8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

2505979:EPZ47 RS24200
gene id: 2505979:EPZ47_RS24200
uniprot id: A0A4P7PLA2
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.

2505979:EPZ47 RS23725
gene id: 2505979:EPZ47_RS23725
uniprot id: A0A4P7PL02
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-I fumarase family.
messages: Catalyzes the reversible hydration of fumarate to (S)-malate.
messages: Homodimer.

2505979:EPZ47 RS21455
gene id: 2505979:EPZ47_RS21455
uniprot id: A0A4P7PQ02
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

2505979:EPZ47 RS03210
gene id: 2505979:EPZ47_RS03210
uniprot id: A0A4P7PBD9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

2505979:EPZ47 RS08320
gene id: 2505979:EPZ47_RS08320
uniprot id: A0A4V1CAF4
names: Similarity
messages: Belongs to the BolA/IbaG family.

2505979:EPZ47 RS09880
gene id: 2505979:EPZ47_RS09880
uniprot id: A0A4P7PEG0
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.

2505979:EPZ47 RS26725
gene id: 2505979:EPZ47_RS26725
uniprot id: A0A4P7PME4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

2505979:EPZ47 RS25125
gene id: 2505979:EPZ47_RS25125
uniprot id: A0A4P7PM61
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2505979:EPZ47 RS25530
gene id: 2505979:EPZ47_RS25530
uniprot id: A0A4P7PLV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

2505979:EPZ47 RS19430
gene id: 2505979:EPZ47_RS19430
uniprot id: A0A4P7PJ58
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2505979:EPZ47 RS18930
gene id: 2505979:EPZ47_RS18930
uniprot id: A0A4P7PIT3
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

2505979:EPZ47 RS28700
gene id: 2505979:EPZ47_RS28700
uniprot id: A0A4P7PPH7
names: Similarity
messages: Belongs to the Rsd/AlgQ family.

2505979:EPZ47 RS06200
gene id: 2505979:EPZ47_RS06200
uniprot id: A0A4P7PE40
names: Similarity
messages: Belongs to the ferredoxin--NADP reductase type 1 family.

2505979:EPZ47 RS05855
gene id: 2505979:EPZ47_RS05855
uniprot id: A0A4P7PCK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KdsA family.
messages: Cytoplasm

2505979:EPZ47 RS18940
gene id: 2505979:EPZ47_RS18940
uniprot id: A0A4P7PIS2
names: Subcellular Location Annotation
messages: Cytoplasm

2505979:EPZ47 RS23510
gene id: 2505979:EPZ47_RS23510
uniprot id: A0A4P7PKX9
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

2505979:EPZ47 RS27490
gene id: 2505979:EPZ47_RS27490
uniprot id: A0A4V1CBG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

2505979:EPZ47 RS03140
gene id: 2505979:EPZ47_RS03140
uniprot id: A0A4V1CA57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

2505979:EPZ47 RS03205
gene id: 2505979:EPZ47_RS03205
uniprot id: A0A4P7PBK6
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

2505979:EPZ47 RS05860
gene id: 2505979:EPZ47_RS05860
uniprot id: A0A4P7PCK2
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

2505979:EPZ47 RS09570
gene id: 2505979:EPZ47_RS09570
uniprot id: A0A4P7PFM2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
messages: Cytoplasm

2505979:EPZ47 RS21095
gene id: 2505979:EPZ47_RS21095
uniprot id: A0A4V1CB42
names: Subcellular Location Annotation
messages: Membrane

2505979:EPZ47 RS07350
gene id: 2505979:EPZ47_RS07350
uniprot id: A0A4P7PDC4
names: Similarity
messages: Belongs to the SAICAR synthetase family.

2505979:EPZ47 RS20320
gene id: 2505979:EPZ47_RS20320
uniprot id: A0A4P7PK04
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

2505979:EPZ47 RS01660
gene id: 2505979:EPZ47_RS01660
uniprot id: A0A4P7PAM5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.

2505979:EPZ47 RS01585
gene id: 2505979:EPZ47_RS01585
uniprot id: A0A4P7PBR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

2505979:EPZ47 RS04560
gene id: 2505979:EPZ47_RS04560
uniprot id: A0A4P7PC31
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2505979:EPZ47 RS26940
gene id: 2505979:EPZ47_RS26940
uniprot id: A0A4P7PMK1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HesB/IscA family.
messages: Binds 1 iron-sulfur cluster per subunit.
messages: Homodimer.
messages: Required for insertion of 4Fe-4S clusters for at least IspG.

2505979:EPZ47 RS12350
gene id: 2505979:EPZ47_RS12350
uniprot id: A0A4P7PFM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

2505979:EPZ47 RS26780
gene id: 2505979:EPZ47_RS26780
uniprot id: A0A4P7PMM0
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: Methylated by PrmB.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

2505979:EPZ47 RS25040
gene id: 2505979:EPZ47_RS25040
uniprot id: A0A4P7PM92
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acetylates the N-terminal alanine of ribosomal protein bS18.
messages: Belongs to the acetyltransferase family. RimI subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2505979:EPZ47 RS26720
gene id: 2505979:EPZ47_RS26720
uniprot id: A0A4P7PMI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

2505979:EPZ47 RS02515
gene id: 2505979:EPZ47_RS02515
uniprot id: A0A4P7PB70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

2505979:EPZ47 RS21010
gene id: 2505979:EPZ47_RS21010
uniprot id: A0A4P7PJS7
names: Similarity
messages: Belongs to the citrate synthase family.

2505979:EPZ47 RS21840
gene id: 2505979:EPZ47_RS21840
uniprot id: A0A4P7PK40
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

2505979:EPZ47 RS29900
gene id: 2505979:EPZ47_RS29900
uniprot id: A0A4V1CBK6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

2505979:EPZ47 RS03015
gene id: 2505979:EPZ47_RS03015
uniprot id: A0A4P7PCC2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease gamma subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

2505979:EPZ47 RS18900
gene id: 2505979:EPZ47_RS18900
uniprot id: A0A4P7PJV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.
messages: This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.

2505979:EPZ47 RS00090
gene id: 2505979:EPZ47_RS00090
uniprot id: A0A4P7P9R8
names: Similarity
messages: Belongs to the OsmC/Ohr family.

2505979:EPZ47 RS21795
gene id: 2505979:EPZ47_RS21795
uniprot id: A0A4P7PK94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

2505979:EPZ47 RS03000
gene id: 2505979:EPZ47_RS03000
uniprot id: A0A4P7PBF2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the urease beta subunit family.
messages: Cytoplasm
messages: Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.

2505979:EPZ47 RS24590
gene id: 2505979:EPZ47_RS24590
uniprot id: A0A4P7PLI7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b family.
messages: Binds 2 heme groups non-covalently.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

2505979:EPZ47 RS24605
gene id: 2505979:EPZ47_RS24605
uniprot id: A0A4V1CBA7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

2505979:EPZ47 RS26735
gene id: 2505979:EPZ47_RS26735
uniprot id: A0A4P7PMH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

2505979:EPZ47 RS21830
gene id: 2505979:EPZ47_RS21830
uniprot id: A0A4P7PK37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmE/CycJ family.
messages: Cell membrane
messages: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.

2505979:EPZ47 RS07290
gene id: 2505979:EPZ47_RS07290
uniprot id: A0A4P7PD75
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.

2505979:EPZ47 RS02780
gene id: 2505979:EPZ47_RS02780
uniprot id: A0A4P7PB68
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

2505979:EPZ47 RS08410
gene id: 2505979:EPZ47_RS08410
uniprot id: A0A4P7PDR9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS1 family.
messages: Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.

2505979:EPZ47 RS00650
gene id: 2505979:EPZ47_RS00650
uniprot id: A0A4V1CA11
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

2505979:EPZ47 RS29830
gene id: 2505979:EPZ47_RS29830
uniprot id: A0A4P7PNX6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

2505979:EPZ47 RS24510
gene id: 2505979:EPZ47_RS24510
uniprot id: A0A4P7PLF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

2505979:EPZ47 RS26660
gene id: 2505979:EPZ47_RS26660
uniprot id: A0A4P7PN29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

2505979:EPZ47 RS18265
gene id: 2505979:EPZ47_RS18265
uniprot id: A0A4P7PIH7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2505979:EPZ47 RS26775
gene id: 2505979:EPZ47_RS26775
uniprot id: A0A4P7PMF0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

2505979:EPZ47 RS00010
gene id: 2505979:EPZ47_RS00010
uniprot id: A0A4P7P9M4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

2505979:EPZ47 RS09195
gene id: 2505979:EPZ47_RS09195
uniprot id: A0A4P7PE98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribosome modulation factor family.
messages: Cytoplasm
messages: During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes).

2505979:EPZ47 RS26125
gene id: 2505979:EPZ47_RS26125
uniprot id: A0A4P7PMA8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

2505979:EPZ47 RS10350
gene id: 2505979:EPZ47_RS10350
uniprot id: A0A4P7PEQ6
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

2505979:EPZ47 RS18920
gene id: 2505979:EPZ47_RS18920
uniprot id: A0A4P7PJ43
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

2505979:EPZ47 RS28130
gene id: 2505979:EPZ47_RS28130
uniprot id: A0A4P7PP90
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Homodimer. Forms a membrane-associated complex with FtsX.
messages: Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.

2505979:EPZ47 RS01945
gene id: 2505979:EPZ47_RS01945
uniprot id: A0A4P7PAR9
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).

2505979:EPZ47 RS28990
gene id: 2505979:EPZ47_RS28990
uniprot id: A0A4P7PNG2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

2505979:EPZ47 RS08735
gene id: 2505979:EPZ47_RS08735
uniprot id: A0A4P7PF78
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

2505979:EPZ47 RS27230
gene id: 2505979:EPZ47_RS27230
uniprot id: A0A4P7PPC6
names: Function
names: Similarity
messages: Belongs to the PqqA family.
messages: Required for coenzyme pyrroloquinoline quinone (PQQ) biosynthesis. PQQ is probably formed by cross-linking a specific glutamate to a specific tyrosine residue and excising these residues from the peptide.

2505979:EPZ47 RS08180
gene id: 2505979:EPZ47_RS08180
uniprot id: A0A4P7PDM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

2505979:EPZ47 RS26765
gene id: 2505979:EPZ47_RS26765
uniprot id: A0A4P7PN03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

2505979:EPZ47 RS27150
gene id: 2505979:EPZ47_RS27150
uniprot id: A0A4P7PMN3
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

2505979:EPZ47 RS02665
gene id: 2505979:EPZ47_RS02665
uniprot id: A0A4P7PB53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-to-5' exoribonuclease specific for small oligoribonucleotides.
messages: Belongs to the oligoribonuclease family.
messages: Cytoplasm

2505979:EPZ47 RS26770
gene id: 2505979:EPZ47_RS26770
uniprot id: A0A4P7PMJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

2505979:EPZ47 RS26950
gene id: 2505979:EPZ47_RS26950
uniprot id: A0A4P7PNP0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HemJ family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

2505979:EPZ47 RS07785
gene id: 2505979:EPZ47_RS07785
uniprot id: A0A4P7PDJ4
names: Similarity
messages: Belongs to the arginase family. Agmatinase subfamily.

2505979:EPZ47 RS21000
gene id: 2505979:EPZ47_RS21000
uniprot id: A0A4P7PKD0
names: Cofactor
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cell inner membrane
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD.
messages: The heme is bound between the two transmembrane subunits.

2505979:EPZ47 RS05805
gene id: 2505979:EPZ47_RS05805
uniprot id: A0A4P7PCJ9
names: Similarity
messages: Belongs to the Skp family.

2505979:EPZ47 RS29485
gene id: 2505979:EPZ47_RS29485
uniprot id: A0A4P7PQK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

2505979:EPZ47 RS03235
gene id: 2505979:EPZ47_RS03235
uniprot id: A0A4P7PCI1
names: Similarity
messages: Belongs to the SUI1 family.

2505979:EPZ47 RS05240
gene id: 2505979:EPZ47_RS05240
uniprot id: A0A4P7PCB7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

2505979:EPZ47 RS12860
gene id: 2505979:EPZ47_RS12860
uniprot id: A0A4P7PGC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP G family.
messages: Cell inner membrane
messages: Membrane

2505979:EPZ47 RS28575
gene id: 2505979:EPZ47_RS28575
uniprot id: A0A4P7PND4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.

2505979:EPZ47 RS20500
gene id: 2505979:EPZ47_RS20500
uniprot id: A0A4P7PJN4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

2505979:EPZ47 RS28000
gene id: 2505979:EPZ47_RS28000
uniprot id: A0A4P7PN24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF HJR family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

2505979:EPZ47 RS09095
gene id: 2505979:EPZ47_RS09095
uniprot id: A0A4P7PE35
names: Function
names: Similarity
messages: Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
messages: Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.

2505979:EPZ47 RS04600
gene id: 2505979:EPZ47_RS04600
uniprot id: A0A4P7PC21
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PAPS reductase family. CysD subfamily.
messages: Heterodimer composed of CysD, the smaller subunit, and CysN.
messages: With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.

2505979:EPZ47 RS05915
gene id: 2505979:EPZ47_RS05915
uniprot id: A0A4P7PCN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoS subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.

2505979:EPZ47 RS25565
gene id: 2505979:EPZ47_RS25565
uniprot id: A0A4P7PMC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0114 family.
messages: Cell membrane
messages: Membrane

2505979:EPZ47 RS23235
gene id: 2505979:EPZ47_RS23235
uniprot id: A0A4P7PKT4
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

2505979:EPZ47 RS28120
gene id: 2505979:EPZ47_RS28120
uniprot id: A0A4P7PN40
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoH subfamily.
messages: Cytoplasm
messages: Interacts with the RNA polymerase core enzyme.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.

2505979:EPZ47 RS28345
gene id: 2505979:EPZ47_RS28345
uniprot id: A0A4V1CBH6
names: Similarity
messages: Belongs to the glutamine synthetase family.

2505979:EPZ47 RS04895
gene id: 2505979:EPZ47_RS04895
uniprot id: A0A4P7PDH1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase bacterial subunit 4 family.
messages: Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron.
messages: Heterooctamer of two A chains, two B chains, two C chains and two D chains.
messages: Membrane

2505979:EPZ47 RS18220
gene id: 2505979:EPZ47_RS18220
uniprot id: A0A4P7PIN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2505979:EPZ47 RS24880
gene id: 2505979:EPZ47_RS24880
uniprot id: A0A4P7PLM3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

2505979:EPZ47 RS28185
gene id: 2505979:EPZ47_RS28185
uniprot id: A0A4P7PPL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

2505979:EPZ47 RS26790
gene id: 2505979:EPZ47_RS26790
uniprot id: A0A4P7PMK7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

2505979:EPZ47 RS05690
gene id: 2505979:EPZ47_RS05690
uniprot id: A0A4V1CAA4
names: Subcellular Location Annotation
messages: Cytoplasm

2505979:EPZ47 RS04400
gene id: 2505979:EPZ47_RS04400
uniprot id: A0A4P7PBY1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

2505979:EPZ47 RS28505
gene id: 2505979:EPZ47_RS28505
uniprot id: A0A4P7PNX0
names: Function
names: Similarity
names: Subunit
messages: Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.
messages: Belongs to the ZapA family. Type 1 subfamily.
messages: Homodimer. Interacts with FtsZ.

2505979:EPZ47 RS26830
gene id: 2505979:EPZ47_RS26830
uniprot id: A0A4P7PMN1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

2505979:EPZ47 RS19640
gene id: 2505979:EPZ47_RS19640
uniprot id: A0A4V1CB15
names: Cofactor
names: Similarity
messages: Belongs to the PTPS family. QueD subfamily.
messages: Binds 1 zinc ion per subunit.

2505979:EPZ47 RS05765
gene id: 2505979:EPZ47_RS05765
uniprot id: A0A4P7PCK9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

2505979:EPZ47 RS05205
gene id: 2505979:EPZ47_RS05205
uniprot id: A0A4P7PC86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

2505979:EPZ47 RS00635
gene id: 2505979:EPZ47_RS00635
uniprot id: A0A4P7PA33
names: Function
messages: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

2505979:EPZ47 RS24595
gene id: 2505979:EPZ47_RS24595
uniprot id: A0A4P7PMI2
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Rieske iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
messages: Membrane
messages: The Rieske protein is a high potential 2Fe-2S protein.
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

2505979:EPZ47 RS04225
gene id: 2505979:EPZ47_RS04225
uniprot id: A0A4P7PC71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

2505979:EPZ47 RS14180
gene id: 2505979:EPZ47_RS14180
uniprot id: A0A4P7PP49
names: Function
names: Similarity
messages: Belongs to the PqqA family.
messages: Required for coenzyme pyrroloquinoline quinone (PQQ) biosynthesis. PQQ is probably formed by cross-linking a specific glutamate to a specific tyrosine residue and excising these residues from the peptide.

2505979:EPZ47 RS09435
gene id: 2505979:EPZ47_RS09435
uniprot id: A0A4P7PEF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfur carrier protein TusA family.
messages: Cytoplasm
messages: Sulfur carrier protein which probably makes part of a sulfur-relay system.

2505979:EPZ47 RS04625
gene id: 2505979:EPZ47_RS04625
uniprot id: A0A4P7PD54
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

2505979:EPZ47 RS09865
gene id: 2505979:EPZ47_RS09865
uniprot id: A0A4V1CAI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

2505979:EPZ47 RS26090
gene id: 2505979:EPZ47_RS26090
uniprot id: A0A4P7PN89
names: Similarity
messages: Belongs to the UPF0250 family.

2505979:EPZ47 RS21930
gene id: 2505979:EPZ47_RS21930
uniprot id: A0A4P7PLN6
names: Subcellular Location Annotation
messages: Membrane

2505979:EPZ47 RS21800
gene id: 2505979:EPZ47_RS21800
uniprot id: A0A4P7PL86
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatB family.
messages: Cell membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

2505979:EPZ47 RS02670
gene id: 2505979:EPZ47_RS02670
uniprot id: A0A4P7PB63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

2505979:EPZ47 RS24475
gene id: 2505979:EPZ47_RS24475
uniprot id: A0A4P7PLC6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

2505979:EPZ47 RS24580
gene id: 2505979:EPZ47_RS24580
uniprot id: A0A4P7PLJ0
names: Similarity
messages: Belongs to the GST superfamily. HSP26 family.

2505979:EPZ47 RS12600
gene id: 2505979:EPZ47_RS12600
uniprot id: A0A4P7PG00
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

2505979:EPZ47 RS25500
gene id: 2505979:EPZ47_RS25500
uniprot id: A0A4P7PMG4
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

2505979:EPZ47 RS29025
gene id: 2505979:EPZ47_RS29025
uniprot id: A0A4P7PP65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

2505979:EPZ47 RS18915
gene id: 2505979:EPZ47_RS18915
uniprot id: A0A4P7PJC9
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

2505979:EPZ47 RS03120
gene id: 2505979:EPZ47_RS03120
uniprot id: A0A4P7PBC7
names: Similarity
messages: Belongs to the CobH/CbiC family.

2505979:EPZ47 RS00350
gene id: 2505979:EPZ47_RS00350
uniprot id: A0A4P7P9Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUA5 family. TsaC subfamily.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.

2505979:EPZ47 RS12645
gene id: 2505979:EPZ47_RS12645
uniprot id: A0A4P7PG83
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2505979:EPZ47 RS05210
gene id: 2505979:EPZ47_RS05210
uniprot id: A0A4P7PDF6
names: Function
names: Similarity
messages: A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
messages: Belongs to the NifU family.

2505979:EPZ47 RS02765
gene id: 2505979:EPZ47_RS02765
uniprot id: A0A4V1CA50
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

2505979:EPZ47 RS29000
gene id: 2505979:EPZ47_RS29000
uniprot id: A0A4P7PNI0
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

2505979:EPZ47 RS21545
gene id: 2505979:EPZ47_RS21545
uniprot id: A0A4P7PK18
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.

2505979:EPZ47 RS07460
gene id: 2505979:EPZ47_RS07460
uniprot id: A0A4P7PDE1
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

2505979:EPZ47 RS04405
gene id: 2505979:EPZ47_RS04405
uniprot id: A0A4P7PC09
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.

2505979:EPZ47 RS23215
gene id: 2505979:EPZ47_RS23215
uniprot id: A0A4P7PMA1
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

2505979:EPZ47 RS21815
gene id: 2505979:EPZ47_RS21815
uniprot id: A0A4P7PKR1
names: Function
names: Similarity
messages: Belongs to the CcmH/CycL/Ccl2/NrfF family.
messages: Possible subunit of a heme lyase.

2505979:EPZ47 RS26655
gene id: 2505979:EPZ47_RS26655
uniprot id: A0A4V1CBE5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

2505979:EPZ47 RS26625
gene id: 2505979:EPZ47_RS26625
uniprot id: A0A4P7PMC7
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

2505979:EPZ47 RS23005
gene id: 2505979:EPZ47_RS23005
uniprot id: A0A4P7PM70
names: Similarity
messages: Belongs to the prokaryotic/mitochondrial release factor family.

2505979:EPZ47 RS09405
gene id: 2505979:EPZ47_RS09405
uniprot id: A0A4P7PE94
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 1 copper ion per subunit, denoted as copper B.
messages: Binds 2 heme groups per subunit, denoted as high- and low-spin.
messages: Membrane

2505979:EPZ47 RS11250
gene id: 2505979:EPZ47_RS11250
uniprot id: A0A4P7PF99
names: Subcellular Location Annotation
messages: Membrane

2505979:EPZ47 RS24565
gene id: 2505979:EPZ47_RS24565
uniprot id: A0A4P7PLX1
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIS family. GmhA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
messages: Cytoplasm
messages: Homotetramer.
messages: The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

2505979:EPZ47 RS03175
gene id: 2505979:EPZ47_RS03175
uniprot id: A0A4P7PBC8
names: Similarity
messages: Belongs to the transcriptional regulatory Fis family.

2505979:EPZ47 RS23320
gene id: 2505979:EPZ47_RS23320
uniprot id: A0A4V1CB83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Membrane

2505979:EPZ47 RS27260
gene id: 2505979:EPZ47_RS27260
uniprot id: A0A4P7PMT9
names: Similarity
messages: Belongs to the UPF0057 (PMP3) family.

2505979:EPZ47 RS26460
gene id: 2505979:EPZ47_RS26460
uniprot id: A0A4P7PMU5
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).

2505979:EPZ47 RS21790
gene id: 2505979:EPZ47_RS21790
uniprot id: A0A4P7PK31
names: Similarity
messages: Belongs to the outer membrane porin (Opr) (TC 1.B.25) family.

2505979:EPZ47 RS26240
gene id: 2505979:EPZ47_RS26240
uniprot id: A0A4P7PNB9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

2505979:EPZ47 RS26750
gene id: 2505979:EPZ47_RS26750
uniprot id: A0A4P7PP00
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

2505979:EPZ47 RS26755
gene id: 2505979:EPZ47_RS26755
uniprot id: A0A4V1CBE7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

2505979:EPZ47 RS12365
gene id: 2505979:EPZ47_RS12365
uniprot id: A0A4P7PFN6
names: Subcellular Location Annotation
messages: Membrane

2505979:EPZ47 RS21980
gene id: 2505979:EPZ47_RS21980
uniprot id: A0A4P7PLP4
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

2505979:EPZ47 RS04105
gene id: 2505979:EPZ47_RS04105
uniprot id: A0A4V1CA74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

2505979:EPZ47 RS05435
gene id: 2505979:EPZ47_RS05435
uniprot id: A0A4P7PCR2
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

2505979:EPZ47 RS07295
gene id: 2505979:EPZ47_RS07295
uniprot id: A0A4P7PD66
names: Similarity
messages: Belongs to the RseA family.

2505979:EPZ47 RS05280
gene id: 2505979:EPZ47_RS05280
uniprot id: A0A4P7PCH4
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

2505979:EPZ47 RS05770
gene id: 2505979:EPZ47_RS05770
uniprot id: A0A4P7PCH2
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2505979:EPZ47 RS26685
gene id: 2505979:EPZ47_RS26685
uniprot id: A0A4P7PMG2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

2505979:EPZ47 RS04120
gene id: 2505979:EPZ47_RS04120
uniprot id: A0A4P7PBV4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

2505979:EPZ47 RS05230
gene id: 2505979:EPZ47_RS05230
uniprot id: A0A4P7PCG3
names: Similarity
messages: Belongs to the adrenodoxin/putidaredoxin family.

2505979:EPZ47 RS27165
gene id: 2505979:EPZ47_RS27165
uniprot id: A0A4P7PP61
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

2505979:EPZ47 RS26690
gene id: 2505979:EPZ47_RS26690
uniprot id: A0A4P7PMJ2
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

2505979:EPZ47 RS08755
gene id: 2505979:EPZ47_RS08755
uniprot id: A0A4P7PDX5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

2505979:EPZ47 RS24315
gene id: 2505979:EPZ47_RS24315
uniprot id: A0A4P7PL98
names: Similarity
messages: Belongs to the PhoH family.

2505979:EPZ47 RS07905
gene id: 2505979:EPZ47_RS07905
uniprot id: A0A4P7PEQ3
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

2505979:EPZ47 RS26680
gene id: 2505979:EPZ47_RS26680
uniprot id: A0A4P7PMK6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

2505979:EPZ47 RS26745
gene id: 2505979:EPZ47_RS26745
uniprot id: A0A4P7PNL0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

2505979:EPZ47 RS18235
gene id: 2505979:EPZ47_RS18235
uniprot id: A0A4V1CAZ0
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

2505979:EPZ47 RS28820
gene id: 2505979:EPZ47_RS28820
uniprot id: A0A4P7PP27
names: Similarity
messages: Belongs to the P(II) protein family.

2505979:EPZ47 RS26760
gene id: 2505979:EPZ47_RS26760
uniprot id: A0A4P7PN46
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

2505979:EPZ47 RS21805
gene id: 2505979:EPZ47_RS21805
uniprot id: A0A4P7PLL9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
messages: The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.

2505979:EPZ47 RS29505
gene id: 2505979:EPZ47_RS29505
uniprot id: A0A4P7PNT6
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.

2505979:EPZ47 RS09305
gene id: 2505979:EPZ47_RS09305
uniprot id: A0A4P7PE74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

2505979:EPZ47 RS25255
gene id: 2505979:EPZ47_RS25255
uniprot id: A0A4P7PLU5
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

2505979:EPZ47 RS26675
gene id: 2505979:EPZ47_RS26675
uniprot id: A0A4P7PMD6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

2505979:EPZ47 RS26820
gene id: 2505979:EPZ47_RS26820
uniprot id: A0A4P7PMK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

2505979:EPZ47 RS22320
gene id: 2505979:EPZ47_RS22320
uniprot id: A0A4P7PLV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

2505979:EPZ47 RS26840
gene id: 2505979:EPZ47_RS26840
uniprot id: A0A4P7PML3
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

2505979:EPZ47 RS08010
gene id: 2505979:EPZ47_RS08010
uniprot id: A0A4P7PEX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Cell inner membrane
messages: FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.
messages: Membrane

2505979:EPZ47 RS29435
gene id: 2505979:EPZ47_RS29435
uniprot id: A0A4V1CBJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

2505979:EPZ47 RS26855
gene id: 2505979:EPZ47_RS26855
uniprot id: A0A4P7PP16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

2505979:EPZ47 RS20505
gene id: 2505979:EPZ47_RS20505
uniprot id: A0A4P7PKL8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

2505979:EPZ47 RS09485
gene id: 2505979:EPZ47_RS09485
uniprot id: A0A4P7PEG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
messages: Cytoplasm
messages: Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).

2505979:EPZ47 RS26650
gene id: 2505979:EPZ47_RS26650
uniprot id: A0A4P7PNY5
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

2505979:EPZ47 RS18225
gene id: 2505979:EPZ47_RS18225
uniprot id: A0A4P7PJK3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

2505979:EPZ47 RS26740
gene id: 2505979:EPZ47_RS26740
uniprot id: A0A4P7PMJ9
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

2505979:EPZ47 RS18145
gene id: 2505979:EPZ47_RS18145
uniprot id: A0A4P7PIE8
names: Similarity
messages: Belongs to the ClpA/ClpB family.

2505979:EPZ47 RS28335
gene id: 2505979:EPZ47_RS28335
uniprot id: A0A4P7PPC7
names: Similarity
messages: Belongs to the glutamine synthetase family.

2505979:EPZ47 RS06470
gene id: 2505979:EPZ47_RS06470
uniprot id: A0A4P7PE85
names: Similarity
messages: Belongs to the ABC transporter superfamily.

2505979:EPZ47 RS05165
gene id: 2505979:EPZ47_RS05165
uniprot id: A0A4P7PDL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Cell inner membrane
messages: Membrane

2505979:EPZ47 RS11795
gene id: 2505979:EPZ47_RS11795
uniprot id: A0A4P7PFJ5
names: Similarity
messages: Belongs to the UDPGP type 2 family.

2505979:EPZ47 RS02730
gene id: 2505979:EPZ47_RS02730
uniprot id: A0A4P7PB57
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

2505979:EPZ47 RS28095
gene id: 2505979:EPZ47_RS28095
uniprot id: A0A4P7PN53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

2505979:EPZ47 RS04415
gene id: 2505979:EPZ47_RS04415
uniprot id: A0A4P7PBW8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Cell inner membrane
messages: Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins.
messages: Membrane

2505979:EPZ47 RS07275
gene id: 2505979:EPZ47_RS07275
uniprot id: A0A4V1CAD4
names: Function
names: Similarity
messages: An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.
messages: Belongs to the SdhE FAD assembly factor family.

2505979:EPZ47 RS08380
gene id: 2505979:EPZ47_RS08380
uniprot id: A0A4P7PDY1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

2505979:EPZ47 RS19435
gene id: 2505979:EPZ47_RS19435
uniprot id: A0A4P7PIZ8
names: Subcellular Location Annotation
messages: Membrane

2505979:EPZ47 RS18150
gene id: 2505979:EPZ47_RS18150
uniprot id: A0A4P7PIG2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

2505979:EPZ47 RS29380
gene id: 2505979:EPZ47_RS29380
uniprot id: A0A4P7PQI4
names: Similarity
names: Subunit
messages: Belongs to the bacterial histone-like protein family.
messages: Heterodimer of an alpha and a beta chain.

2505979:EPZ47 RS24600
gene id: 2505979:EPZ47_RS24600
uniprot id: A0A4P7PMY7
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

2505979:EPZ47 RS29845
gene id: 2505979:EPZ47_RS29845
uniprot id: A0A4P7PQU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

2505979:EPZ47 RS29890
gene id: 2505979:EPZ47_RS29890
uniprot id: A0A4P7PQ96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

2505979:EPZ47 RS28955
gene id: 2505979:EPZ47_RS28955
uniprot id: A0A4P7PNK8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

2505979:EPZ47 RS21005
gene id: 2505979:EPZ47_RS21005
uniprot id: A0A4P7PK76
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome b560 family.
messages: Membrane
messages: Membrane-anchoring subunit of succinate dehydrogenase (SDH).
messages: Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD. The complex can form homotrimers.
messages: The heme is bound between the two transmembrane subunits.

2505979:EPZ47 RS21825
gene id: 2505979:EPZ47_RS21825
uniprot id: A0A4P7PK58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
messages: Cell inner membrane
messages: Membrane

2505979:EPZ47 RS24540
gene id: 2505979:EPZ47_RS24540
uniprot id: A0A4P7PMH5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

2505979:EPZ47 RS29820
gene id: 2505979:EPZ47_RS29820
uniprot id: A0A4P7PNW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

2505979:EPZ47 RS09135
gene id: 2505979:EPZ47_RS09135
uniprot id: A0A4P7PE34
names: Similarity
messages: Belongs to the sigma-70 factor family. ECF subfamily.