243276:TPANIC RS05430
gene id: 243276:TPANIC_RS05430
uniprot id: O83575
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS00760
gene id: 243276:TPANIC_RS00760
uniprot id: O83183
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS03510
gene id: 243276:TPANIC_RS03510
uniprot id: O83705
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS04125
gene id: 243276:TPANIC_RS04125
uniprot id: O83806
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

243276:TPANIC RS03585
gene id: 243276:TPANIC_RS03585
uniprot id: O07888
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell membrane
messages: Controls the rotational direction of flagella during chemotaxis.

243276:TPANIC RS02350
gene id: 243276:TPANIC_RS02350
uniprot id: O83497
names: Subcellular Location Annotation
messages: Membrane

243276:TPANIC RS00950
gene id: 243276:TPANIC_RS00950
uniprot id: O83221
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

243276:TPANIC RS03045
gene id: 243276:TPANIC_RS03045
uniprot id: O83625
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

243276:TPANIC RS03095
gene id: 243276:TPANIC_RS03095
uniprot id: O83634
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SbcD family.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

243276:TPANIC RS03610
gene id: 243276:TPANIC_RS03610
uniprot id: F7IW78
names: Similarity
messages: Belongs to the FlgD family.

243276:TPANIC RS04845
gene id: 243276:TPANIC_RS04845
uniprot id: O83949
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Molecular chaperone. Has ATPase activity.

243276:TPANIC RS02295
gene id: 243276:TPANIC_RS02295
uniprot id: O83485
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

243276:TPANIC RS03335
gene id: 243276:TPANIC_RS03335
uniprot id: O83679
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

243276:TPANIC RS01870
gene id: 243276:TPANIC_RS01870
uniprot id: O83398
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

243276:TPANIC RS01030
gene id: 243276:TPANIC_RS01030
uniprot id: O83237
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

243276:TPANIC RS02570
gene id: 243276:TPANIC_RS02570
uniprot id: O83537
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity).

243276:TPANIC RS00365
gene id: 243276:TPANIC_RS00365
uniprot id: O83114
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243276:TPANIC RS01715
gene id: 243276:TPANIC_RS01715
uniprot id: P74935
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

243276:TPANIC RS04520
gene id: 243276:TPANIC_RS04520
uniprot id: O83889
names: Function
names: Similarity
messages: Belongs to the thioredoxin family.
messages: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.

243276:TPANIC RS01825
gene id: 243276:TPANIC_RS01825
uniprot id: O83387
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

243276:TPANIC RS01510
gene id: 243276:TPANIC_RS01510
uniprot id: O83327
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

243276:TPANIC RS01890
gene id: 243276:TPANIC_RS01890
uniprot id: O83402
names: Subcellular Location Annotation
messages: Membrane

243276:TPANIC RS00990
gene id: 243276:TPANIC_RS00990
uniprot id: O83229
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8 (By similarity). Interacts with ribosomal silencing factor RsfS, which may inhibit ribosomal subunit association.

243276:TPANIC RS00295
gene id: 243276:TPANIC_RS00295
uniprot id: O83100
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

243276:TPANIC RS04665
gene id: 243276:TPANIC_RS04665
uniprot id: F7IVV4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A probable RNA chaperone. Forms a complex with KhpA which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.
messages: Belongs to the KhpB RNA-binding protein family.
messages: Cytoplasm
messages: Forms a complex with KhpA.
messages: Has an N-terminal Jag-N domain and 2 RNA-binding domains (KH and R3H).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243276:TPANIC RS01490
gene id: 243276:TPANIC_RS01490
uniprot id: O83323
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Probably part of the ABC transporter complex RfuABCD involved in riboflavin import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is probably composed of two ATP-binding proteins (RfuB), two transmembrane proteins (RfuC and RfuD) and a solute-binding protein (RfuA).

243276:TPANIC RS02035
gene id: 243276:TPANIC_RS02035
uniprot id: O83431
names: Similarity
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.

243276:TPANIC RS01225
gene id: 243276:TPANIC_RS01225
uniprot id: O83270
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

243276:TPANIC RS02635
gene id: 243276:TPANIC_RS02635
uniprot id: O83548
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

243276:TPANIC RS01865
gene id: 243276:TPANIC_RS01865
uniprot id: O83396
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS00475
gene id: 243276:TPANIC_RS00475
uniprot id: O83135
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

243276:TPANIC RS00150
gene id: 243276:TPANIC_RS00150
uniprot id: P23033
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: This is one of the most abundant proteins of T.pallidum and is highly antigenic.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

243276:TPANIC RS01330
gene id: 243276:TPANIC_RS01330
uniprot id: O83288
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

243276:TPANIC RS04625
gene id: 243276:TPANIC_RS04625
uniprot id: O83909
names: Cofactor
names: Similarity
messages: Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.
messages: Binds 3 [4Fe-4S] clusters per subunit.

243276:TPANIC RS03395
gene id: 243276:TPANIC_RS03395
uniprot id: Q08255
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 2 family.
messages: Cell membrane
messages: May be involved in the transport of sugars. May have a role in chemotaxis.

243276:TPANIC RS04825
gene id: 243276:TPANIC_RS04825
uniprot id: O83945
names: Function
names: Similarity
messages: Belongs to the Dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

243276:TPANIC RS02990
gene id: 243276:TPANIC_RS02990
uniprot id: O83615
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

243276:TPANIC RS04375
gene id: 243276:TPANIC_RS04375
uniprot id: O83857
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

243276:TPANIC RS02230
gene id: 243276:TPANIC_RS02230
uniprot id: O83469
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS00515
gene id: 243276:TPANIC_RS00515
uniprot id: P74933
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity.

243276:TPANIC RS01215
gene id: 243276:TPANIC_RS01215
uniprot id: O83268
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

243276:TPANIC RS03540
gene id: 243276:TPANIC_RS03540
uniprot id: Q56339
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Cell membrane
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum (By similarity).

243276:TPANIC RS02090
gene id: 243276:TPANIC_RS02090
uniprot id: O83443
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

243276:TPANIC RS03745
gene id: 243276:TPANIC_RS03745
uniprot id: O83737
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

243276:TPANIC RS00700
gene id: 243276:TPANIC_RS00700
uniprot id: O83174
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS03495
gene id: 243276:TPANIC_RS03495
uniprot id: O83702
names: Similarity
messages: Belongs to the RecJ family.

243276:TPANIC RS04250
gene id: 243276:TPANIC_RS04250
uniprot id: O83833
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

243276:TPANIC RS02585
gene id: 243276:TPANIC_RS02585
uniprot id: O83539
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

243276:TPANIC RS03285
gene id: 243276:TPANIC_RS03285
uniprot id: O83670
names: Subcellular Location Annotation
messages: Periplasmic flagellum

243276:TPANIC RS03660
gene id: 243276:TPANIC_RS03660
uniprot id: O83720
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity).
messages: Interacts with ribosomal protein uL14 (rplN).

243276:TPANIC RS04965
gene id: 243276:TPANIC_RS04965
uniprot id: O08399
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

243276:TPANIC RS01920
gene id: 243276:TPANIC_RS01920
uniprot id: O83408
names: Similarity
messages: Belongs to the DprA/Smf family.

243276:TPANIC RS01650
gene id: 243276:TPANIC_RS01650
uniprot id: O83357
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

243276:TPANIC RS01970
gene id: 243276:TPANIC_RS01970
uniprot id: O83418
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

243276:TPANIC RS04070
gene id: 243276:TPANIC_RS04070
uniprot id: O83795
names: Similarity
messages: Belongs to the desulfoferrodoxin family.

243276:TPANIC RS05645
gene id: 243276:TPANIC_RS05645
uniprot id: O83875
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

243276:TPANIC RS00940
gene id: 243276:TPANIC_RS00940
uniprot id: O83219
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

243276:TPANIC RS04465
gene id: 243276:TPANIC_RS04465
uniprot id: O83878
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

243276:TPANIC RS01055
gene id: 243276:TPANIC_RS01055
uniprot id: O83242
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

243276:TPANIC RS04005
gene id: 243276:TPANIC_RS04005
uniprot id: O83787
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

243276:TPANIC RS02870
gene id: 243276:TPANIC_RS02870
uniprot id: O83591
names: Subcellular Location Annotation
messages: Membrane

243276:TPANIC RS00530
gene id: 243276:TPANIC_RS00530
uniprot id: O83146
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homodimer.

243276:TPANIC RS03410
gene id: 243276:TPANIC_RS03410
uniprot id: P96130
names: Function
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.
messages: Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) (By similarity).

243276:TPANIC RS04765
gene id: 243276:TPANIC_RS04765
uniprot id: O83933
names: Similarity
messages: Belongs to the TP096X family.

243276:TPANIC RS02430
gene id: 243276:TPANIC_RS02430
uniprot id: O83512
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MreD family.
messages: Membrane

243276:TPANIC RS04950
gene id: 243276:TPANIC_RS04950
uniprot id: O83968
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS03450
gene id: 243276:TPANIC_RS03450
uniprot id: O83692
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

243276:TPANIC RS02015
gene id: 243276:TPANIC_RS02015
uniprot id: O83427
names: Subcellular Location Annotation
messages: Nucleus

243276:TPANIC RS03420
gene id: 243276:TPANIC_RS03420
uniprot id: P96128
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

243276:TPANIC RS00270
gene id: 243276:TPANIC_RS00270
uniprot id: O83094
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS01660
gene id: 243276:TPANIC_RS01660
uniprot id: O83359
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.
messages: Responsible for synthesis of pseudouridine from uracil.

243276:TPANIC RS00460
gene id: 243276:TPANIC_RS00460
uniprot id: O83132
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: Cytoplasm

243276:TPANIC RS02590
gene id: 243276:TPANIC_RS02590
uniprot id: O83540
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity).

243276:TPANIC RS04255
gene id: 243276:TPANIC_RS04255
uniprot id: O83834
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

243276:TPANIC RS00130
gene id: 243276:TPANIC_RS00130
uniprot id: O83070
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Membrane

243276:TPANIC RS03590
gene id: 243276:TPANIC_RS03590
uniprot id: O07887
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MotB family.
messages: Cell inner membrane
messages: Each stator complex is composed of 4 MotA and 2 MotB subunits. 2 A subunits and 1 B subunit are thought to form a single ion channel, so that each stator complex contains two channels (By similarity).
messages: MotA and MotB comprise the stator element of the flagellar motor complex. Required for the rotation of the flagellar motor. Might be a linker that fastens the torque-generating machinery to the cell wall (By similarity).

243276:TPANIC RS00930
gene id: 243276:TPANIC_RS00930
uniprot id: O83217
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

243276:TPANIC RS05500
gene id: 243276:TPANIC_RS05500
uniprot id: P19649
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Tmp may serve as a porin or transport protein for large molecules.
messages: To T.phagedenis TmpB.

243276:TPANIC RS02420
gene id: 243276:TPANIC_RS02420
uniprot id: O83510
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cytoplasm
messages: Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.
messages: Forms polymers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243276:TPANIC RS00970
gene id: 243276:TPANIC_RS00970
uniprot id: O83225
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

243276:TPANIC RS03685
gene id: 243276:TPANIC_RS03685
uniprot id: O83725
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

243276:TPANIC RS04285
gene id: 243276:TPANIC_RS04285
uniprot id: P21990
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial flagellin family.
messages: Component of the core of the flagella.
messages: Periplasm
messages: Periplasmic flagellum
messages: The flagellum consists of an outer layer composed of repeating units of FlaA around a core that contains several antigenically related polypeptides. Interacts via its C-terminus with FliW; a synthetic peptide of residues 229-247 partially blocks binding to FliW (PubMed:16936039).

243276:TPANIC RS05570
gene id: 243276:TPANIC_RS05570
uniprot id: P56822
names: Similarity
messages: To T.pallidum TP_0127, TP_0618 and TP_0619.

243276:TPANIC RS02475
gene id: 243276:TPANIC_RS02475
uniprot id: O83519
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity).

243276:TPANIC RS00340
gene id: 243276:TPANIC_RS00340
uniprot id: O83109
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS02080
gene id: 243276:TPANIC_RS02080
uniprot id: O83441
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity).

243276:TPANIC RS04735
gene id: 243276:TPANIC_RS04735
uniprot id: O83927
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

243276:TPANIC RS04745
gene id: 243276:TPANIC_RS04745
uniprot id: O83929
names: Subcellular Location Annotation
messages: Membrane

243276:TPANIC RS01945
gene id: 243276:TPANIC_RS01945
uniprot id: O83413
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

243276:TPANIC RS02825
gene id: 243276:TPANIC_RS02825
uniprot id: O83582
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS00800
gene id: 243276:TPANIC_RS00800
uniprot id: O83191
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

243276:TPANIC RS01955
gene id: 243276:TPANIC_RS01955
uniprot id: O83415
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliG family.
messages: Membrane

243276:TPANIC RS00975
gene id: 243276:TPANIC_RS00975
uniprot id: O83226
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

243276:TPANIC RS04270
gene id: 243276:TPANIC_RS04270
uniprot id: O83837
names: Similarity
messages: Belongs to the UPF0164 family.

243276:TPANIC RS00010
gene id: 243276:TPANIC_RS00010
uniprot id: O83048
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA which binds and tethers DNA polymerases and other proteins to the DNA. The DNA replisome complex has a single clamp-loading complex (3 tau and 1 each of delta, delta', psi and chi subunits) which binds 3 Pol III cores (1 core on the leading strand and 2 on the lagging strand) each with a beta sliding clamp dimer. Additional proteins in the replisome are other copies of gamma, psi and chi, Ssb, DNA helicase and RNA primase.

243276:TPANIC RS05580
gene id: 243276:TPANIC_RS05580
uniprot id: O83355
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS03125
gene id: 243276:TPANIC_RS03125
uniprot id: O83640
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

243276:TPANIC RS03260
gene id: 243276:TPANIC_RS03260
uniprot id: O83665
names: Function
names: Subcellular Location Annotation
messages: Component of the core of the flagella.
messages: Periplasmic flagellum

243276:TPANIC RS00145
gene id: 243276:TPANIC_RS00145
uniprot id: O54312
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm

243276:TPANIC RS04835
gene id: 243276:TPANIC_RS04835
uniprot id: O83947
names: Subcellular Location Annotation
messages: Membrane

243276:TPANIC RS03240
gene id: 243276:TPANIC_RS03240
uniprot id: O83660
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243276:TPANIC RS00280
gene id: 243276:TPANIC_RS00280
uniprot id: O83096
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

243276:TPANIC RS04165
gene id: 243276:TPANIC_RS04165
uniprot id: O83814
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

243276:TPANIC RS02190
gene id: 243276:TPANIC_RS02190
uniprot id: O83463
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS03415
gene id: 243276:TPANIC_RS03415
uniprot id: P96129
names: Similarity
messages: Belongs to the peptidase S66 family.

243276:TPANIC RS02660
gene id: 243276:TPANIC_RS02660
uniprot id: O83553
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Long' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.
messages: Cytoplasm
messages: Homodimer.
messages: Non-allosteric.

243276:TPANIC RS00945
gene id: 243276:TPANIC_RS00945
uniprot id: O83220
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

243276:TPANIC RS03680
gene id: 243276:TPANIC_RS03680
uniprot id: O83724
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

243276:TPANIC RS00960
gene id: 243276:TPANIC_RS00960
uniprot id: O83223
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

243276:TPANIC RS04365
gene id: 243276:TPANIC_RS04365
uniprot id: O83855
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

243276:TPANIC RS00300
gene id: 243276:TPANIC_RS00300
uniprot id: O83101
names: Subunit
messages: Homotetramer.

243276:TPANIC RS03180
gene id: 243276:TPANIC_RS03180
uniprot id: O83647
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

243276:TPANIC RS00915
gene id: 243276:TPANIC_RS00915
uniprot id: O83214
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

243276:TPANIC RS01010
gene id: 243276:TPANIC_RS01010
uniprot id: O83234
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

243276:TPANIC RS00330
gene id: 243276:TPANIC_RS00330
uniprot id: O83107
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

243276:TPANIC RS02975
gene id: 243276:TPANIC_RS02975
uniprot id: O83612
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

243276:TPANIC RS01270
gene id: 243276:TPANIC_RS01270
uniprot id: O83279
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.
messages: Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
messages: Cell inner membrane

243276:TPANIC RS01595
gene id: 243276:TPANIC_RS01595
uniprot id: O83347
names: Similarity
messages: Belongs to the Skp family.

243276:TPANIC RS01335
gene id: 243276:TPANIC_RS01335
uniprot id: O83289
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the branched chain amino acid transporter family.
messages: Membrane

243276:TPANIC RS02020
gene id: 243276:TPANIC_RS02020
uniprot id: O83428
names: Similarity
messages: Belongs to the phosphohexose mutase family.

243276:TPANIC RS01860
gene id: 243276:TPANIC_RS01860
uniprot id: O83395
names: Similarity
messages: Belongs to the helicase family. RAD25/XPB subfamily.

243276:TPANIC RS00160
gene id: 243276:TPANIC_RS00160
uniprot id: O83075
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity).

243276:TPANIC RS02895
gene id: 243276:TPANIC_RS02895
uniprot id: O83598
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HPr family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.
messages: Phosphorylation on Ser-46 inhibits the phosphoryl transfer from enzyme I to HPr.

243276:TPANIC RS00305
gene id: 243276:TPANIC_RS00305
uniprot id: O83102
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

243276:TPANIC RS03945
gene id: 243276:TPANIC_RS03945
uniprot id: P27771
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

243276:TPANIC RS00835
gene id: 243276:TPANIC_RS00835
uniprot id: P96117
names: Function
names: Similarity
messages: Belongs to the ABC transporter superfamily.
messages: Part of an ATP-driven transport system TroABCD for zinc.

243276:TPANIC RS04195
gene id: 243276:TPANIC_RS04195
uniprot id: O83820
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity).

243276:TPANIC RS02195
gene id: 243276:TPANIC_RS02195
uniprot id: O83464
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
messages: Cytoplasm

243276:TPANIC RS01495
gene id: 243276:TPANIC_RS01495
uniprot id: O83324
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell inner membrane
messages: Probably part of the ABC transporter complex RfuABCD involved in riboflavin import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is probably composed of two ATP-binding proteins (RfuB), two transmembrane proteins (RfuC and RfuD) and a solute-binding protein (RfuA).

243276:TPANIC RS02355
gene id: 243276:TPANIC_RS02355
uniprot id: O83498
names: Similarity
messages: Belongs to the adenylyl cyclase class-3 family.

243276:TPANIC RS04405
gene id: 243276:TPANIC_RS04405
uniprot id: O83863
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

243276:TPANIC RS01935
gene id: 243276:TPANIC_RS01935
uniprot id: O83411
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

243276:TPANIC RS03925
gene id: 243276:TPANIC_RS03925
uniprot id: P21991
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial flagellin family.
messages: Component of the core of the flagella.
messages: Periplasm
messages: Periplasmic flagellum
messages: The flagellum consists of an outer layer composed of repeating units of FlaA around a core that contains several antigenically related polypeptides. Interacts with FliW; a synthetic peptide of FlaB1 (residues 229-247) partially blocks binding of this protein to FliW (PubMed:16936039).

243276:TPANIC RS02985
gene id: 243276:TPANIC_RS02985
uniprot id: O83614
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity).
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

243276:TPANIC RS02425
gene id: 243276:TPANIC_RS02425
uniprot id: O83511
names: Function
names: Similarity
messages: Belongs to the MreC family.
messages: Involved in formation and maintenance of cell shape.

243276:TPANIC RS01425
gene id: 243276:TPANIC_RS01425
uniprot id: O83307
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

243276:TPANIC RS02795
gene id: 243276:TPANIC_RS02795
uniprot id: O83577
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family.
messages: Membrane

243276:TPANIC RS03380
gene id: 243276:TPANIC_RS03380
uniprot id: Q56346
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

243276:TPANIC RS03205
gene id: 243276:TPANIC_RS03205
uniprot id: O83653
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

243276:TPANIC RS04590
gene id: 243276:TPANIC_RS04590
uniprot id: O83903
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm

243276:TPANIC RS04670
gene id: 243276:TPANIC_RS04670
uniprot id: O66103
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell inner membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

243276:TPANIC RS02755
gene id: 243276:TPANIC_RS02755
uniprot id: O83570
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

243276:TPANIC RS03310
gene id: 243276:TPANIC_RS03310
uniprot id: O83674
names: Similarity
messages: Belongs to the YggT family.

243276:TPANIC RS02405
gene id: 243276:TPANIC_RS02405
uniprot id: O83506
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

243276:TPANIC RS03190
gene id: 243276:TPANIC_RS03190
uniprot id: O83649
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 divalent metal cations. Magnesium or manganese.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex (By similarity).
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease (By similarity).

243276:TPANIC RS04990
gene id: 243276:TPANIC_RS04990
uniprot id: O83975
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

243276:TPANIC RS01480
gene id: 243276:TPANIC_RS01480
uniprot id: Q56328
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BMP lipoprotein family.
messages: Cell inner membrane
messages: Monomer in solution (PubMed:23404400). The complex is probably composed of two ATP-binding proteins (RfuB), two transmembrane proteins (RfuC and RfuD) and a solute-binding protein (RfuA) (Probable).
messages: Probably part of the ABC transporter complex RfuABCD involved in riboflavin import. Binds riboflavin.

243276:TPANIC RS00500
gene id: 243276:TPANIC_RS00500
uniprot id: O83140
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

243276:TPANIC RS05045
gene id: 243276:TPANIC_RS05045
uniprot id: O83984
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

243276:TPANIC RS02530
gene id: 243276:TPANIC_RS02530
uniprot id: O83530
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

243276:TPANIC RS03750
gene id: 243276:TPANIC_RS03750
uniprot id: O83738
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).

243276:TPANIC RS00215
gene id: 243276:TPANIC_RS00215
uniprot id: O83084
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

243276:TPANIC RS02455
gene id: 243276:TPANIC_RS02455
uniprot id: O83518
names: Similarity
messages: Belongs to the hexokinase family.

243276:TPANIC RS04595
gene id: 243276:TPANIC_RS04595
uniprot id: O83904
names: Subcellular Location Annotation
messages: Membrane

243276:TPANIC RS04150
gene id: 243276:TPANIC_RS04150
uniprot id: O83811
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS01460
gene id: 243276:TPANIC_RS01460
uniprot id: O83317
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

243276:TPANIC RS01290
gene id: 243276:TPANIC_RS01290
uniprot id: O66076
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Cell membrane
messages: This protein catalyzes the committed step to the synthesis of the acidic phospholipids.

243276:TPANIC RS03370
gene id: 243276:TPANIC_RS03370
uniprot id: O83685
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS02485
gene id: 243276:TPANIC_RS02485
uniprot id: O83521
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

243276:TPANIC RS04400
gene id: 243276:TPANIC_RS04400
uniprot id: O83862
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

243276:TPANIC RS01710
gene id: 243276:TPANIC_RS01710
uniprot id: O83369
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Also involved in hydrogenase metallocenter assembly, probably by participating in the nickel insertion step. This function in hydrogenase biosynthesis requires chaperone activity and the presence of the metal-binding domain, but not PPIase activity (By similarity).
messages: Belongs to the FKBP-type PPIase family.
messages: Cytoplasm
messages: Folding helper with both chaperone and peptidyl-prolyl cis-trans isomerase (PPIase) activities. Chaperone activity prevents aggregation of unfolded or partially folded proteins and promotes their correct folding. PPIases catalyze the cis-trans isomerization of Xaa-Pro bonds of peptides, which accelerates slow steps of protein folding and thus shortens the lifetime of intermediates. Both strategies lower the concentration of intermediates and increase the productivity and yield of the folding reaction.
messages: The C-terminal region binds nickel ions.
messages: The N-terminal region consists of two globular folded domains that contain prolyl isomerase and chaperone activities.

243276:TPANIC RS03105
gene id: 243276:TPANIC_RS03105
uniprot id: O83636
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

243276:TPANIC RS02945
gene id: 243276:TPANIC_RS02945
uniprot id: O83605
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

243276:TPANIC RS01005
gene id: 243276:TPANIC_RS01005
uniprot id: O83233
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

243276:TPANIC RS03575
gene id: 243276:TPANIC_RS03575
uniprot id: F7IUB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Membrane

243276:TPANIC RS01515
gene id: 243276:TPANIC_RS01515
uniprot id: O83328
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

243276:TPANIC RS04740
gene id: 243276:TPANIC_RS04740
uniprot id: O83928
names: Subcellular Location Annotation
messages: Membrane

243276:TPANIC RS04975
gene id: 243276:TPANIC_RS04975
uniprot id: O83972
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
messages: Tetramer of two alpha and two beta subunits.
messages: Under complex allosteric control mediated by deoxynucleoside triphosphates and ATP binding. The type of nucleotide bound at the specificity site determines substrate preference. It seems probable that ATP makes the enzyme reduce CDP and UDP, dGTP favors ADP reduction and dTTP favors GDP reduction (By similarity).

243276:TPANIC RS02120
gene id: 243276:TPANIC_RS02120
uniprot id: P29722
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS02085
gene id: 243276:TPANIC_RS02085
uniprot id: O83442
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity).

243276:TPANIC RS00585
gene id: 243276:TPANIC_RS00585
uniprot id: O83154
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

243276:TPANIC RS02965
gene id: 243276:TPANIC_RS02965
uniprot id: O83610
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).

243276:TPANIC RS00850
gene id: 243276:TPANIC_RS00850
uniprot id: F7IW50
names: Similarity
messages: Belongs to the DtxR/MntR family.

243276:TPANIC RS00185
gene id: 243276:TPANIC_RS00185
uniprot id: O83080
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

243276:TPANIC RS01930
gene id: 243276:TPANIC_RS01930
uniprot id: O83410
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 'phage' integrase family. XerC subfamily.
messages: Cytoplasm
messages: Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.

243276:TPANIC RS03375
gene id: 243276:TPANIC_RS03375
uniprot id: O83686
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

243276:TPANIC RS02725
gene id: 243276:TPANIC_RS02725
uniprot id: O83564
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Cell membrane

243276:TPANIC RS03250
gene id: 243276:TPANIC_RS03250
uniprot id: O83663
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

243276:TPANIC RS03640
gene id: 243276:TPANIC_RS03640
uniprot id: O83716
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
messages: Homohexamer; trimer of homodimers.

243276:TPANIC RS04720
gene id: 243276:TPANIC_RS04720
uniprot id: O83924
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

243276:TPANIC RS04330
gene id: 243276:TPANIC_RS04330
uniprot id: O83848
names: Subcellular Location Annotation
messages: Membrane

243276:TPANIC RS05085
gene id: 243276:TPANIC_RS05085
uniprot id: O83991
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

243276:TPANIC RS01370
gene id: 243276:TPANIC_RS01370
uniprot id: O83293
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. MtaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
messages: Cytoplasm

243276:TPANIC RS00680
gene id: 243276:TPANIC_RS00680
uniprot id: O83170
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TP013X lipoprotein family.
messages: Cell membrane

243276:TPANIC RS05000
gene id: 243276:TPANIC_RS05000
uniprot id: O83977
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

243276:TPANIC RS04030
gene id: 243276:TPANIC_RS04030
uniprot id: O83790
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: The active site is a redox-active disulfide bond.

243276:TPANIC RS03735
gene id: 243276:TPANIC_RS03735
uniprot id: O83735
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methylthiotransferase family. MiaB subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
messages: Cytoplasm
messages: Monomer.

243276:TPANIC RS02740
gene id: 243276:TPANIC_RS02740
uniprot id: O83567
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
messages: Cytoplasm

243276:TPANIC RS02490
gene id: 243276:TPANIC_RS02490
uniprot id: O83522
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

243276:TPANIC RS01600
gene id: 243276:TPANIC_RS01600
uniprot id: O83348
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity).

243276:TPANIC RS01050
gene id: 243276:TPANIC_RS01050
uniprot id: O83241
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

243276:TPANIC RS01590
gene id: 243276:TPANIC_RS01590
uniprot id: O83346
names: Biotechnology
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BamA family.
messages: Both rabbit immune serum and rabbit antiserum specific for extracytoplasmic loop L4 promote bacteria internalization by rabbit peritoneal macrophages. Pools of human syphilitic sera from the USA and Columbia recognize both the N-terminal POTRA-containing and C-terminal beta-barrel domains as well as loop L4, showing this protein stimulates the immune system in both humans and rabbits (PubMed:25825429).
messages: Cell outer membrane
messages: Might be part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
messages: Part of 2 complexes of about 239 and 164 kDa.
messages: Recognized by sera from 42/43 syphilis patients, it shows promise as a diagnostic antigen (PubMed:12904373). In further diagnostic tests for syphilis this protein exhibits a sensitivity of 86% and a specificity of 99%. A fusion with TP0453 (residues 32-287 of TP0453 fused N-terminally to residues 38-450 of TP0326) exhibits a sensitivity of 98% and a specificity of 99%, and exhibits superior accuracy in classifying analytical false-positive samples than a commericially available test, making it a better candiate for diagnosis (PubMed:23100335).
messages: The N-terminus (residues 22-369) partitions into an aqueous phase and is predicted to be periplasmic, while the C-terminus (residues 426-837) partitions into Triton X-114 and has the hallmarks of a beta-stranded protein, suggesting it is membraneous.
messages: The outer membrane of T.pallidum has no lipopolysaccharides, few proteins and is a fluid and very fragile bilayer. Its lack of surface antigenicity is thought to contribute to the ability of the pathogen to evade the human immune system.
messages: Transcribed at low levels, estimated to be present at about 100 molecules per cell (at protein level).

243276:TPANIC RS03195
gene id: 243276:TPANIC_RS03195
uniprot id: O83650
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

243276:TPANIC RS01235
gene id: 243276:TPANIC_RS01235
uniprot id: O83272
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

243276:TPANIC RS01260
gene id: 243276:TPANIC_RS01260
uniprot id: P18193
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the outer layer of the flagella.
messages: Periplasm
messages: Periplasmic flagellum
messages: The flagellum consists of an outer layer composed of repeating units of FlaA around a core that contains several antigenically related polypeptides.

243276:TPANIC RS01160
gene id: 243276:TPANIC_RS01160
uniprot id: O83258
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

243276:TPANIC RS04490
gene id: 243276:TPANIC_RS04490
uniprot id: O83883
names: Similarity
messages: Belongs to the UPF0102 family.

243276:TPANIC RS02450
gene id: 243276:TPANIC_RS02450
uniprot id: O83516
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS05080
gene id: 243276:TPANIC_RS05080
uniprot id: O83990
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate.
messages: Cytoplasm

243276:TPANIC RS03845
gene id: 243276:TPANIC_RS03845
uniprot id: O83754
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

243276:TPANIC RS03405
gene id: 243276:TPANIC_RS03405
uniprot id: Q57321
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.
messages: Cell membrane
messages: Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Probably responsible for the translocation of the substrate across the membrane.
messages: The complex is composed of one ATP-binding protein (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB).

243276:TPANIC RS05265
gene id: 243276:TPANIC_RS05265
uniprot id: P96131
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

243276:TPANIC RS04955
gene id: 243276:TPANIC_RS04955
uniprot id: O83969
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

243276:TPANIC RS03385
gene id: 243276:TPANIC_RS03385
uniprot id: O83687
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

243276:TPANIC RS01735
gene id: 243276:TPANIC_RS01735
uniprot id: O83373
names: Caution
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Could be inactive due to a defective ATP-binding site.

243276:TPANIC RS00935
gene id: 243276:TPANIC_RS00935
uniprot id: O83218
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

243276:TPANIC RS03965
gene id: 243276:TPANIC_RS03965
uniprot id: O83779
names: Similarity
messages: Belongs to the ClpA/ClpB family.

243276:TPANIC RS02675
gene id: 243276:TPANIC_RS02675
uniprot id: O83556
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 2 family.
messages: Periplasm
messages: The ABC transporter complex is composed of one ATP-binding protein (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB).

243276:TPANIC RS02370
gene id: 243276:TPANIC_RS02370
uniprot id: O83501
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.
messages: Membrane

243276:TPANIC RS01020
gene id: 243276:TPANIC_RS01020
uniprot id: O83236
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

243276:TPANIC RS00830
gene id: 243276:TPANIC_RS00830
uniprot id: P96116
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial solute-binding protein 9 family.
messages: Monomer.
messages: Part of the ATP-binding cassette (ABC) transport system TroABC involved in zinc import (PubMed:10400603). Binds zinc with high affinity and specificity and delivers it to the membrane permease for translocation into the cytoplasm (PubMed:10400603).
messages: Periplasm
messages: Was originally thought to be an outer membrane protein with porin-like properties.

243276:TPANIC RS00175
gene id: 243276:TPANIC_RS00175
uniprot id: O83078
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell inner membrane
messages: Part of an ATP-driven transport system TP_0034/TP_0035/TP_0036 for a metal. Probably responsible for energy coupling to the transport system.

243276:TPANIC RS02860
gene id: 243276:TPANIC_RS02860
uniprot id: O83589
names: Subcellular Location Annotation
messages: Membrane

243276:TPANIC RS02100
gene id: 243276:TPANIC_RS02100
uniprot id: O83445
names: Subcellular Location Annotation
messages: Membrane

243276:TPANIC RS01655
gene id: 243276:TPANIC_RS01655
uniprot id: O83358
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS03550
gene id: 243276:TPANIC_RS03550
uniprot id: O83710
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell inner membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin (By similarity).

243276:TPANIC RS05225
gene id: 243276:TPANIC_RS05225
uniprot id: O83232
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

243276:TPANIC RS03400
gene id: 243276:TPANIC_RS03400
uniprot id: Q56342
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Galactose/methyl galactoside importer (TC 3.A.1.2.3) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system.
messages: The complex is composed of one ATP-binding protein (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB).

243276:TPANIC RS04780
gene id: 243276:TPANIC_RS04780
uniprot id: P19478
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0423 family.
messages: Cell membrane
messages: This antigen is a pathogen-specific membrane immunogen.

243276:TPANIC RS00250
gene id: 243276:TPANIC_RS00250
uniprot id: O83090
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1 (By similarity).
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

243276:TPANIC RS04985
gene id: 243276:TPANIC_RS04985
uniprot id: O83974
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

243276:TPANIC RS04200
gene id: 243276:TPANIC_RS04200
uniprot id: O83821
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

243276:TPANIC RS02105
gene id: 243276:TPANIC_RS02105
uniprot id: O83446
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

243276:TPANIC RS03135
gene id: 243276:TPANIC_RS03135
uniprot id: O83642
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.

243276:TPANIC RS03675
gene id: 243276:TPANIC_RS03675
uniprot id: O83723
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

243276:TPANIC RS04805
gene id: 243276:TPANIC_RS04805
uniprot id: O83941
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS04085
gene id: 243276:TPANIC_RS04085
uniprot id: O83798
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

243276:TPANIC RS01795
gene id: 243276:TPANIC_RS01795
uniprot id: O83382
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

243276:TPANIC RS03390
gene id: 243276:TPANIC_RS03390
uniprot id: F7IV43
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

243276:TPANIC RS04655
gene id: 243276:TPANIC_RS04655
uniprot id: O66106
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

243276:TPANIC RS02310
gene id: 243276:TPANIC_RS02310
uniprot id: O83488
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

243276:TPANIC RS01885
gene id: 243276:TPANIC_RS01885
uniprot id: O83401
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurF subfamily.
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

243276:TPANIC RS03800
gene id: 243276:TPANIC_RS03800
uniprot id: P07643
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To T.phagedenis TmpA.

243276:TPANIC RS02805
gene id: 243276:TPANIC_RS02805
uniprot id: O83578
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KHG/KDPG aldolase family.
messages: Cytoplasm
messages: Homotrimer.

243276:TPANIC RS00900
gene id: 243276:TPANIC_RS00900
uniprot id: O83211
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS03365
gene id: 243276:TPANIC_RS03365
uniprot id: O83684
names: Similarity
messages: To B.burgdorferi BB0340.

243276:TPANIC RS03605
gene id: 243276:TPANIC_RS03605
uniprot id: O07884
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.

243276:TPANIC RS04075
gene id: 243276:TPANIC_RS04075
uniprot id: O83796
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

243276:TPANIC RS03935
gene id: 243276:TPANIC_RS03935
uniprot id: O83772
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

243276:TPANIC RS01900
gene id: 243276:TPANIC_RS01900
uniprot id: O83404
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell inner membrane
messages: Self-interacts. Interacts with FtsZ.

243276:TPANIC RS04880
gene id: 243276:TPANIC_RS04880
uniprot id: O83956
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule (By similarity).

243276:TPANIC RS05115
gene id: 243276:TPANIC_RS05115
uniprot id: O83998
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

243276:TPANIC RS05075
gene id: 243276:TPANIC_RS05075
uniprot id: O83989
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

243276:TPANIC RS02335
gene id: 243276:TPANIC_RS02335
uniprot id: O83493
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS03275
gene id: 243276:TPANIC_RS03275
uniprot id: O83668
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
messages: Homodimer.

243276:TPANIC RS01690
gene id: 243276:TPANIC_RS01690
uniprot id: O83365
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell inner membrane

243276:TPANIC RS03480
gene id: 243276:TPANIC_RS03480
uniprot id: O83699
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription (By similarity).

243276:TPANIC RS00005
gene id: 243276:TPANIC_RS00005
uniprot id: O83047
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).

243276:TPANIC RS05335
gene id: 243276:TPANIC_RS05335
uniprot id: O83676
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

243276:TPANIC RS01200
gene id: 243276:TPANIC_RS01200
uniprot id: O83265
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

243276:TPANIC RS00190
gene id: 243276:TPANIC_RS00190
uniprot id: Q56343
names: Subcellular Location Annotation
messages: Membrane

243276:TPANIC RS04510
gene id: 243276:TPANIC_RS04510
uniprot id: O83887
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

243276:TPANIC RS04215
gene id: 243276:TPANIC_RS04215
uniprot id: O83824
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell inner membrane

243276:TPANIC RS03795
gene id: 243276:TPANIC_RS03795
uniprot id: O83748
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
messages: Cytoplasm

243276:TPANIC RS01170
gene id: 243276:TPANIC_RS01170
uniprot id: O83261
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

243276:TPANIC RS00765
gene id: 243276:TPANIC_RS00765
uniprot id: O83184
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS04390
gene id: 243276:TPANIC_RS04390
uniprot id: O83860
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

243276:TPANIC RS04470
gene id: 243276:TPANIC_RS04470
uniprot id: O83879
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

243276:TPANIC RS00845
gene id: 243276:TPANIC_RS00845
uniprot id: P96119
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Part of an ATP-driven transport system TroABCD for zinc.

243276:TPANIC RS02270
gene id: 243276:TPANIC_RS02270
uniprot id: O83478
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS02665
gene id: 243276:TPANIC_RS02665
uniprot id: O83554
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

243276:TPANIC RS02315
gene id: 243276:TPANIC_RS02315
uniprot id: O83489
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

243276:TPANIC RS05100
gene id: 243276:TPANIC_RS05100
uniprot id: O83995
names: Subcellular Location Annotation
messages: Membrane

243276:TPANIC RS00955
gene id: 243276:TPANIC_RS00955
uniprot id: O83222
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

243276:TPANIC RS03255
gene id: 243276:TPANIC_RS03255
uniprot id: O83664
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
messages: Belongs to the FliW family.
messages: Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (PubMed:16936039).
messages: Cytoplasm
messages: Interacts with translational regulator CsrA (By similarity). Interacts with flagellins FlaB1, FlaB2 and FlaB3.

243276:TPANIC RS02655
gene id: 243276:TPANIC_RS02655
uniprot id: O83552
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell inner membrane
messages: Cytoplasm
messages: Monomer.

243276:TPANIC RS02495
gene id: 243276:TPANIC_RS02495
uniprot id: O83523
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell inner membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

243276:TPANIC RS04110
gene id: 243276:TPANIC_RS04110
uniprot id: O83803
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

243276:TPANIC RS01390
gene id: 243276:TPANIC_RS01390
uniprot id: O83297
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS00375
gene id: 243276:TPANIC_RS00375
uniprot id: O83116
names: Similarity
messages: Belongs to the polysaccharide synthase family.

243276:TPANIC RS01960
gene id: 243276:TPANIC_RS01960
uniprot id: O83416
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliH family.
messages: Cytoplasm
messages: Needed for flagellar regrowth and assembly.

243276:TPANIC RS03515
gene id: 243276:TPANIC_RS03515
uniprot id: O83706
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS02865
gene id: 243276:TPANIC_RS02865
uniprot id: O83590
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.
messages: Cell inner membrane
messages: Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
messages: The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE).

243276:TPANIC RS04615
gene id: 243276:TPANIC_RS04615
uniprot id: O83907
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

243276:TPANIC RS03630
gene id: 243276:TPANIC_RS03630
uniprot id: O83714
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

243276:TPANIC RS01180
gene id: 243276:TPANIC_RS01180
uniprot id: O83262
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

243276:TPANIC RS02300
gene id: 243276:TPANIC_RS02300
uniprot id: O83486
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS05135
gene id: 243276:TPANIC_RS05135
uniprot id: O84001
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

243276:TPANIC RS01265
gene id: 243276:TPANIC_RS01265
uniprot id: O83278
names: Function
names: Similarity
messages: Belongs to the bacterial histone-like protein family.
messages: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.

243276:TPANIC RS01720
gene id: 243276:TPANIC_RS01720
uniprot id: P74936
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

243276:TPANIC RS00600
gene id: 243276:TPANIC_RS00600
uniprot id: O83156
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243276:TPANIC RS02155
gene id: 243276:TPANIC_RS02155
uniprot id: O83456
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

243276:TPANIC RS04810
gene id: 243276:TPANIC_RS04810
uniprot id: O83942
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: Homohexamer.

243276:TPANIC RS01095
gene id: 243276:TPANIC_RS01095
uniprot id: O83249
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

243276:TPANIC RS01580
gene id: 243276:TPANIC_RS01580
uniprot id: O83343
names: Subcellular Location Annotation
messages: Membrane

243276:TPANIC RS05040
gene id: 243276:TPANIC_RS05040
uniprot id: O83983
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

243276:TPANIC RS00615
gene id: 243276:TPANIC_RS00615
uniprot id: O83159
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP).
messages: Cytoplasm
messages: Monomer.

243276:TPANIC RS04960
gene id: 243276:TPANIC_RS04960
uniprot id: O83970
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

243276:TPANIC RS02595
gene id: 243276:TPANIC_RS02595
uniprot id: O83541
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity).

243276:TPANIC RS03315
gene id: 243276:TPANIC_RS03315
uniprot id: O83675
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-C family. DnaE subfamily.
messages: Cytoplasm
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the PolIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex (By similarity).
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity).

243276:TPANIC RS01040
gene id: 243276:TPANIC_RS01040
uniprot id: O83239
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

243276:TPANIC RS01925
gene id: 243276:TPANIC_RS01925
uniprot id: O83409
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Binds two Mg(2+) per subunit.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

243276:TPANIC RS00155
gene id: 243276:TPANIC_RS00155
uniprot id: O83074
names: Subcellular Location Annotation
messages: Membrane

243276:TPANIC RS05005
gene id: 243276:TPANIC_RS05005
uniprot id: O83978
names: Subcellular Location Annotation
messages: Membrane

243276:TPANIC RS04930
gene id: 243276:TPANIC_RS04930
uniprot id: O83964
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsK/SpoIIIE/SftA family.
messages: Cell inner membrane
messages: Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains form the DNA pump, and the gamma subdomain is a regulatory subdomain (By similarity).
messages: Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity).
messages: Homohexamer. Forms a ring that surrounds DNA (By similarity).

243276:TPANIC RS00865
gene id: 243276:TPANIC_RS00865
uniprot id: P96122
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.
messages: Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine.

243276:TPANIC RS03530
gene id: 243276:TPANIC_RS03530
uniprot id: O83709
names: Similarity
names: Subcellular Location Annotation
messages: Membrane
messages: To B.burgdorferi BB0265.

243276:TPANIC RS05130
gene id: 243276:TPANIC_RS05130
uniprot id: P16665
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Dps family.
messages: Homodecamer; either linked or stabilized by disulfide bonds.
messages: May play an important structural role in the outer membrane.

243276:TPANIC RS05065
gene id: 243276:TPANIC_RS05065
uniprot id: O83988
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

243276:TPANIC RS05015
gene id: 243276:TPANIC_RS05015
uniprot id: P29725
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS03545
gene id: 243276:TPANIC_RS03545
uniprot id: Q56338
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.
messages: Cell membrane
messages: Involved in the export of flagellum proteins.

243276:TPANIC RS03950
gene id: 243276:TPANIC_RS03950
uniprot id: O83776
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

243276:TPANIC RS00180
gene id: 243276:TPANIC_RS00180
uniprot id: O83079
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell inner membrane
messages: Part of an ATP-driven transport system TP_0034/TP_0035/TP_0036 for a metal.

243276:TPANIC RS00445
gene id: 243276:TPANIC_RS00445
uniprot id: O83129
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

243276:TPANIC RS01785
gene id: 243276:TPANIC_RS01785
uniprot id: P96126
names: Cofactor
names: Function
names: PTM
names: Subcellular Location Annotation
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheY seems to regulate the clockwise (CW) rotation (By similarity).
messages: Phosphorylated by CheA.

243276:TPANIC RS04370
gene id: 243276:TPANIC_RS04370
uniprot id: O83856
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

243276:TPANIC RS04660
gene id: 243276:TPANIC_RS04660
uniprot id: O66105
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).

243276:TPANIC RS02400
gene id: 243276:TPANIC_RS02400
uniprot id: O83505
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Binds two Mg(2+) per subunit.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

243276:TPANIC RS04045
gene id: 243276:TPANIC_RS04045
uniprot id: P74934
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

243276:TPANIC RS03995
gene id: 243276:TPANIC_RS03995
uniprot id: O83785
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

243276:TPANIC RS00825
gene id: 243276:TPANIC_RS00825
uniprot id: P96115
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

243276:TPANIC RS01470
gene id: 243276:TPANIC_RS01470
uniprot id: O83319
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

243276:TPANIC RS00220
gene id: 243276:TPANIC_RS00220
uniprot id: O83085
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
messages: Binds 1 zinc ion per subunit.
messages: Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism.

243276:TPANIC RS01385
gene id: 243276:TPANIC_RS01385
uniprot id: O83296
names: Similarity
messages: Belongs to the ParA family.

243276:TPANIC RS05120
gene id: 243276:TPANIC_RS05120
uniprot id: O83999
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

243276:TPANIC RS01680
gene id: 243276:TPANIC_RS01680
uniprot id: O83363
names: Similarity
messages: Belongs to the Nth/MutY family.

243276:TPANIC RS02515
gene id: 243276:TPANIC_RS02515
uniprot id: O83527
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

243276:TPANIC RS04315
gene id: 243276:TPANIC_RS04315
uniprot id: O83845
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD (By similarity).

243276:TPANIC RS00625
gene id: 243276:TPANIC_RS00625
uniprot id: O83161
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

243276:TPANIC RS03840
gene id: 243276:TPANIC_RS03840
uniprot id: O83753
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

243276:TPANIC RS02560
gene id: 243276:TPANIC_RS02560
uniprot id: O83535
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell inner membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).

243276:TPANIC RS03695
gene id: 243276:TPANIC_RS03695
uniprot id: O83727
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

243276:TPANIC RS01905
gene id: 243276:TPANIC_RS01905
uniprot id: O83405
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

243276:TPANIC RS04640
gene id: 243276:TPANIC_RS04640
uniprot id: O83913
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

243276:TPANIC RS05020
gene id: 243276:TPANIC_RS05020
uniprot id: O83980
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity).
messages: Consists of two domains; the N-terminal catalytic domain (in this organism this is shorter than usual) and the editing domain; the C-terminal C-Ala domain found in most orthologs is missing. The editing domain removes incorrectly charged amino acids (By similarity).
messages: Cytoplasm

243276:TPANIC RS04560
gene id: 243276:TPANIC_RS04560
uniprot id: O83895
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

243276:TPANIC RS02525
gene id: 243276:TPANIC_RS02525
uniprot id: O83529
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell inner membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.

243276:TPANIC RS03555
gene id: 243276:TPANIC_RS03555
uniprot id: P74932
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Role in flagellar biosynthesis.

243276:TPANIC RS03100
gene id: 243276:TPANIC_RS03100
uniprot id: O83635
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SMC family. SbcC subfamily.
messages: Heterodimer of SbcC and SbcD.
messages: SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity (By similarity).

243276:TPANIC RS04095
gene id: 243276:TPANIC_RS04095
uniprot id: O83800
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

243276:TPANIC RS00290
gene id: 243276:TPANIC_RS00290
uniprot id: O83099
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

243276:TPANIC RS00115
gene id: 243276:TPANIC_RS00115
uniprot id: O83067
names: Subcellular Location Annotation
messages: Membrane

243276:TPANIC RS01140
gene id: 243276:TPANIC_RS01140
uniprot id: O83254
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS02555
gene id: 243276:TPANIC_RS02555
uniprot id: O83534
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS01395
gene id: 243276:TPANIC_RS01395
uniprot id: O83298
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

243276:TPANIC RS02480
gene id: 243276:TPANIC_RS02480
uniprot id: O83520
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

243276:TPANIC RS01285
gene id: 243276:TPANIC_RS01285
uniprot id: O66075
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

243276:TPANIC RS02145
gene id: 243276:TPANIC_RS02145
uniprot id: O83454
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

243276:TPANIC RS01875
gene id: 243276:TPANIC_RS01875
uniprot id: O83399
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

243276:TPANIC RS00345
gene id: 243276:TPANIC_RS00345
uniprot id: O83110
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent (By similarity).
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
messages: The Clp repeat (R) domain probably functions as a substrate-discriminating domain, recruiting aggregated proteins to the ClpB hexamer and/or stabilizing bound proteins. The NBD2 domain is responsible for oligomerization, whereas the NBD1 domain stabilizes the hexamer probably in an ATP-dependent manner. The movement of the coiled-coil domain is essential for ClpB ability to rescue proteins from an aggregated state, probably by pulling apart large aggregated proteins, which are bound between the coiled-coils motifs of adjacent ClpB subunits in the functional hexamer (By similarity).

243276:TPANIC RS01045
gene id: 243276:TPANIC_RS01045
uniprot id: O83240
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

243276:TPANIC RS03635
gene id: 243276:TPANIC_RS03635
uniprot id: O83715
names: Similarity
messages: To T.pallidum TP_0126.

243276:TPANIC RS02750
gene id: 243276:TPANIC_RS02750
uniprot id: O83569
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NiCoT transporter (TC 2.A.52) family.
messages: Cell membrane
messages: Membrane

243276:TPANIC RS01190
gene id: 243276:TPANIC_RS01190
uniprot id: O83263
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell inner membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

243276:TPANIC RS01210
gene id: 243276:TPANIC_RS01210
uniprot id: O83267
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex (By similarity).

243276:TPANIC RS03730
gene id: 243276:TPANIC_RS03730
uniprot id: O83734
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS02820
gene id: 243276:TPANIC_RS02820
uniprot id: O83581
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

243276:TPANIC RS02830
gene id: 243276:TPANIC_RS02830
uniprot id: P29723
names: Cofactor
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
names: Subunit
messages: A pathogen-specific membrane antigen (PubMed:2642466, PubMed:1372297). Most abundant of the membrane lipoproteins, only found in pathogenic treponemes, suggesting that it is an important structural moiety in the cell envelope of virulent treponemal subspecies. A lipopeptide corresponding to the first 6 mature residues induces host (human and mouse) cytokine release by monocyte cell lines via TLR2 and CD14; nonlipidated protein does not stimulate host cells (PubMed:10426995). Stimulates host (human) dendritic cell maturation to become MHC class II-positive antigen presenting cells via TLR2, which depends on lipidation; nonlipidated protein does not stimulate maturation (PubMed:11160304).
messages: A possible D,D-carboxypeptidase, that releases amino acids sequentially from a proteins C-terminus (PubMed:7972112, PubMed:12196546). Has zinc-dependent carboxypeptidase activity on synthetic depsipeptide substrates (PubMed:7972112). May serve to decrease cross-linking of peptidoglycan, promoting the highly sinusous motility of this spirochaete (Probable). Overexpression of the whole protein in E.coli leads to aberrant cell morphology and extrusion of the cytoplasm, while overexpression of a construct with the first 62 resides of the protein fused to PhoA does have this effect, suggesting the whole protein, not the lipoprotein moiety, is toxic (PubMed:7972112). Binds penicillin (PubMed:2647634, PubMed:7972112). Penicillin binding is covalent, does not require lipidation, and is zinc-dependent (PubMed:7972112, PubMed:12196546). While this protein has beta-lactamase activity in vitro, that is probably not its role in vivo, as T.pallidum is very sensitive to penicillin antibiotics (PubMed:12196546).
messages: A recombinant non-lipidated form (residues 20-434) is recognized by human antisera, indicating the lipidation site is not essential for antigenicity, although the acylated lipopeptide clearly is antigenic (PubMed:1372297, PubMed:10426995). The non-lipidated form binds also penicillin (PubMed:7972112).
messages: Carboxypeptidase activity is stimulated by zinc (PubMed:7972112). Penicillin-binding is stimulated by zinc (PubMed:12196546).
messages: Cell inner membrane
messages: Probably a monomer; a non-lipidated construct (residues 22-434) is monomeric in solution but crystallizes as a homodimer.
messages: The N-terminus is blocked (PubMed:2642466). Present as a doublet of low abundance 48 kDa and high abundance 47 kDa proteins (PubMed:2647634, PubMed:2668192, PubMed:1372297). The longer form is probably due to readthrough of the stop codon; the extra amino acids at the C-terminus would be X-Lys-Arg-Gly-Val-Leu-Ser-Arg-Val-Ser, a peptide antibody against this sequence detects only the 48 kDa form (PubMed:2668192).

243276:TPANIC RS02565
gene id: 243276:TPANIC_RS02565
uniprot id: O83536
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

243276:TPANIC RS03580
gene id: 243276:TPANIC_RS03580
uniprot id: P74927
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Cell inner membrane
messages: FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity).

243276:TPANIC RS01195
gene id: 243276:TPANIC_RS01195
uniprot id: O83264
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

243276:TPANIC RS02940
gene id: 243276:TPANIC_RS02940
uniprot id: O83604
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

243276:TPANIC RS03710
gene id: 243276:TPANIC_RS03710
uniprot id: Q56336
names: Function
names: Subcellular Location Annotation
messages: Component of the cytoplasmic filaments that run the length of the organism just underneath the cytoplasmic membrane.
messages: Cytoplasm

243276:TPANIC RS05030
gene id: 243276:TPANIC_RS05030
uniprot id: O83981
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

243276:TPANIC RS03035
gene id: 243276:TPANIC_RS03035
uniprot id: O83623
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

243276:TPANIC RS03025
gene id: 243276:TPANIC_RS03025
uniprot id: O83621
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

243276:TPANIC RS00855
gene id: 243276:TPANIC_RS00855
uniprot id: P96121
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

243276:TPANIC RS03265
gene id: 243276:TPANIC_RS03265
uniprot id: O83666
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

243276:TPANIC RS04980
gene id: 243276:TPANIC_RS04980
uniprot id: O83973
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

243276:TPANIC RS03020
gene id: 243276:TPANIC_RS03020
uniprot id: O83620
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

243276:TPANIC RS04300
gene id: 243276:TPANIC_RS04300
uniprot id: O83842
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FliD family.
messages: Homopentamer.
messages: Periplasm
messages: Periplasmic flagellum
messages: Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end (By similarity).

243276:TPANIC RS02705
gene id: 243276:TPANIC_RS02705
uniprot id: O83561
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.

243276:TPANIC RS03755
gene id: 243276:TPANIC_RS03755
uniprot id: O83739
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

243276:TPANIC RS00485
gene id: 243276:TPANIC_RS00485
uniprot id: O83137
names: Similarity
messages: Belongs to the UMP kinase family.

243276:TPANIC RS03565
gene id: 243276:TPANIC_RS03565
uniprot id: P74930
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Plays a role in the flagellum-specific transport system.

243276:TPANIC RS05110
gene id: 243276:TPANIC_RS05110
uniprot id: O83997
names: Subcellular Location Annotation
messages: Membrane

243276:TPANIC RS01965
gene id: 243276:TPANIC_RS01965
uniprot id: O83417
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cytoplasm
messages: Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum.

243276:TPANIC RS04790
gene id: 243276:TPANIC_RS04790
uniprot id: O83938
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

243276:TPANIC RS03185
gene id: 243276:TPANIC_RS03185
uniprot id: O83648
names: Similarity
messages: Belongs to the phosphohexose mutase family.

243276:TPANIC RS00980
gene id: 243276:TPANIC_RS00980
uniprot id: O83227
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

243276:TPANIC RS02980
gene id: 243276:TPANIC_RS02980
uniprot id: O83613
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

243276:TPANIC RS05380
gene id: 243276:TPANIC_RS05380
uniprot id: O83917
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

243276:TPANIC RS00510
gene id: 243276:TPANIC_RS00510
uniprot id: O83142
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-nucleotidase family.
messages: Cell membrane

243276:TPANIC RS00260
gene id: 243276:TPANIC_RS00260
uniprot id: O83092
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
messages: Tetramer of two alpha and two beta subunits.

243276:TPANIC RS03445
gene id: 243276:TPANIC_RS03445
uniprot id: O83691
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS04010
gene id: 243276:TPANIC_RS04010
uniprot id: O33844
names: Function
names: Similarity
messages: An alpha subtype methylase that recognizes the double-stranded sequence 5'-GATC-3' and methylates A-2 on both strands (Probable) (PubMed:12654995). Directly involved in methyl-directed DNA mismatch repair, DNA replication, and gene expression (By similarity).
messages: Belongs to the N(4)/N(6)-methyltransferase family.

243276:TPANIC RS03595
gene id: 243276:TPANIC_RS03595
uniprot id: O07886
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MotA family.
messages: Cell inner membrane
messages: Each stator complex is composed of 4 MotA and 2 MotB subunits. 2 A subunits and 1 B subunit are thought to form a single ion channel, so that each stator complex contains two channels (By similarity).
messages: MotA and MotB comprise the stator element of the flagellar motor complex. Required for rotation of the flagellar motor. Probable transmembrane proton channel (By similarity).

243276:TPANIC RS01220
gene id: 243276:TPANIC_RS01220
uniprot id: O83269
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

243276:TPANIC RS05105
gene id: 243276:TPANIC_RS05105
uniprot id: O83996
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243276:TPANIC RS04800
gene id: 243276:TPANIC_RS04800
uniprot id: O83940
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

243276:TPANIC RS02960
gene id: 243276:TPANIC_RS02960
uniprot id: O83609
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell inner membrane

243276:TPANIC RS00630
gene id: 243276:TPANIC_RS00630
uniprot id: O83162
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

243276:TPANIC RS04175
gene id: 243276:TPANIC_RS04175
uniprot id: O83816
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
messages: Cytoplasm
messages: Homotetramer.

243276:TPANIC RS02325
gene id: 243276:TPANIC_RS02325
uniprot id: O83491
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.

243276:TPANIC RS04295
gene id: 243276:TPANIC_RS04295
uniprot id: P21992
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial flagellin family.
messages: Component of the core of the flagella.
messages: Periplasm
messages: Periplasmic flagellum
messages: The flagellum consists of an outer layer composed of repeating units of FlaA around a core that contains several antigenically related polypeptides. Interacts with FliW; a synthetic peptide of FlaB1 (residues 229-247) partially blocks binding of this protein to FliW (PubMed:16936039).

243276:TPANIC RS05060
gene id: 243276:TPANIC_RS05060
uniprot id: O83987
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

243276:TPANIC RS01950
gene id: 243276:TPANIC_RS01950
uniprot id: O83414
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Cell inner membrane
messages: The M ring may be actively involved in energy transduction.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of five rings (E,L,P,S, and M) mounted on a central rod. The M ring is integral to the inner membrane of the cell and may be connected to the flagellar rod via the S ring. The S (supramembrane ring) lies just distal to the M ring. The L and P rings lie in the outer membrane and the periplasmic space, respectively (By similarity).

243276:TPANIC RS00575
gene id: 243276:TPANIC_RS00575
uniprot id: O83152
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflC subfamily.
messages: HflC and HflK could regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

243276:TPANIC RS00580
gene id: 243276:TPANIC_RS00580
uniprot id: O83153
names: Function
names: Similarity
messages: Belongs to the ThiD family.
messages: Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates (By similarity).

243276:TPANIC RS01015
gene id: 243276:TPANIC_RS01015
uniprot id: O83235
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

243276:TPANIC RS05010
gene id: 243276:TPANIC_RS05010
uniprot id: O83979
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

243276:TPANIC RS02440
gene id: 243276:TPANIC_RS02440
uniprot id: O83514
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEDS family. MrdB/RodA subfamily.
messages: Cell inner membrane
messages: Peptidoglycan polymerase that is essential for cell wall elongation.

243276:TPANIC RS01060
gene id: 243276:TPANIC_RS01060
uniprot id: O83243
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

243276:TPANIC RS01685
gene id: 243276:TPANIC_RS01685
uniprot id: O83364
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

243276:TPANIC RS03700
gene id: 243276:TPANIC_RS03700
uniprot id: O83728
names: Activity Regulation
names: Domain
names: Function
names: Miscellaneous
names: PTM
names: Similarity
names: Subunit
messages: Activated by light-induced dephosphorylation. Inhibited by dark-induced phosphorylation. Both reactions are catalyzed by PDRP1 (By similarity).
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the reversible phosphorylation of pyruvate and phosphate.
messages: Homodimer.
messages: Phosphorylation of Ser-440 in the dark inactivates the enzyme. Dephosphorylation upon light stimulation reactivates the enzyme (By similarity).
messages: The N-terminal domain contains the ATP/Pi active site, the central domain the pyrophosphate/phosphate carrier histidine, and the C-terminal domain the pyruvate active site.
messages: The reaction takes place in three steps, each mediated by a carrier histidine residue located on the surface of the central domain. The two first partial reactions are catalyzed at an active site located on the N-terminal domain, and the third partial reaction is catalyzed at an active site located on the C-terminal domain. For catalytic turnover, the central domain swivels from the concave surface of the N-terminal domain to that of the C-terminal domain.

243276:TPANIC RS00965
gene id: 243276:TPANIC_RS00965
uniprot id: O83224
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).

243276:TPANIC RS02205
gene id: 243276:TPANIC_RS02205
uniprot id: O83466
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

243276:TPANIC RS02005
gene id: 243276:TPANIC_RS02005
uniprot id: O83425
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

243276:TPANIC RS03120
gene id: 243276:TPANIC_RS03120
uniprot id: O83639
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

243276:TPANIC RS04060
gene id: 243276:TPANIC_RS04060
uniprot id: O07950
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Cell membrane

243276:TPANIC RS00840
gene id: 243276:TPANIC_RS00840
uniprot id: P96118
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Part of an ATP-driven transport system TroABCD for zinc.

243276:TPANIC RS01205
gene id: 243276:TPANIC_RS01205
uniprot id: O83266
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

243276:TPANIC RS04650
gene id: 243276:TPANIC_RS04650
uniprot id: O66107
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

243276:TPANIC RS04730
gene id: 243276:TPANIC_RS04730
uniprot id: O83926
names: Similarity
names: Subunit
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

243276:TPANIC RS01280
gene id: 243276:TPANIC_RS01280
uniprot id: O83281
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.

243276:TPANIC RS01455
gene id: 243276:TPANIC_RS01455
uniprot id: P38369
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the outer membrane OOP (TC 1.B.6) superfamily.
messages: Cell outer membrane
messages: Could function as a porin.

243276:TPANIC RS00440
gene id: 243276:TPANIC_RS00440
uniprot id: O83128
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

243276:TPANIC RS00570
gene id: 243276:TPANIC_RS00570
uniprot id: O83151
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the band 7/mec-2 family. HflK subfamily.
messages: HflC and HflK could encode or regulate a protease.
messages: HflC and HflK may interact to form a multimeric complex.
messages: Membrane

243276:TPANIC RS03150
gene id: 243276:TPANIC_RS03150
uniprot id: O83645
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS05050
gene id: 243276:TPANIC_RS05050
uniprot id: O83985
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Has a putative N-terminal zinc-finger, a middle region with homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

243276:TPANIC RS01420
gene id: 243276:TPANIC_RS01420
uniprot id: O83306
names: Subcellular Location Annotation
messages: Cell membrane

243276:TPANIC RS01075
gene id: 243276:TPANIC_RS01075
uniprot id: O83246
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock (By similarity).

243276:TPANIC RS01670
gene id: 243276:TPANIC_RS01670
uniprot id: O83361
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

243276:TPANIC RS03220
gene id: 243276:TPANIC_RS03220
uniprot id: O83656
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

243276:TPANIC RS00055
gene id: 243276:TPANIC_RS00055
uniprot id: O83059
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

243276:TPANIC RS00995
gene id: 243276:TPANIC_RS00995
uniprot id: O83230
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

243276:TPANIC RS01830
gene id: 243276:TPANIC_RS01830
uniprot id: O83388
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

243276:TPANIC RS01380
gene id: 243276:TPANIC_RS01380
uniprot id: O83295
names: Function
names: Similarity
messages: Belongs to the ParB family.
messages: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication (By similarity).

243276:TPANIC RS02885
gene id: 243276:TPANIC_RS02885
uniprot id: O83595
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

243276:TPANIC RS00025
gene id: 243276:TPANIC_RS00025
uniprot id: O83051
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

243276:TPANIC RS02185
gene id: 243276:TPANIC_RS02185
uniprot id: O83462
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family. Highly divergent.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

243276:TPANIC RS04000
gene id: 243276:TPANIC_RS04000
uniprot id: O83786
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

243276:TPANIC RS01625
gene id: 243276:TPANIC_RS01625
uniprot id: O83351
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

243276:TPANIC RS00380
gene id: 243276:TPANIC_RS00380
uniprot id: O83117
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

243276:TPANIC RS02305
gene id: 243276:TPANIC_RS02305
uniprot id: O83487
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

243276:TPANIC RS02010
gene id: 243276:TPANIC_RS02010
uniprot id: O83426
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell inner membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

243276:TPANIC RS01230
gene id: 243276:TPANIC_RS01230
uniprot id: O83271
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Because the enzyme that would modify Asp-89 to 3-methylthioaspartic acid has not been found in the proteome of this organism, that modification is not predicted.
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

243276:TPANIC RS01800
gene id: 243276:TPANIC_RS01800
uniprot id: O83383
names: Subcellular Location Annotation
messages: Membrane

243276:TPANIC RS03665
gene id: 243276:TPANIC_RS03665
uniprot id: O83721
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

243276:TPANIC RS01565
gene id: 243276:TPANIC_RS01565
uniprot id: P29724
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BMP lipoprotein family.
messages: Binds purine nucleosides and may play a role in purine nucleoside uptake. May be part of an ABC-type nucleoside uptake system. Has highest affinity for guanosine, followed by inosine and adenosine. Has very low affinity for cytidine and does not bind thymidine.
messages: Cell membrane
messages: Encoded in an operon with TP_0320, TP_0321, TP_0322 and TP_0323 that may code for an ABC-type nucleoside uptake system, with TP_0322 and/or TP_0323 encoding putative permeases, and TP_0319 encoding a ligand-binding protein.
messages: Monomer.

243276:TPANIC RS02685
gene id: 243276:TPANIC_RS02685
uniprot id: O83558
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

243276:TPANIC RS05145
gene id: 243276:TPANIC_RS05145
uniprot id: O84003
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.