243273:MG RS00100
gene id: 243273:MG_RS00100
uniprot id: P47266
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Cytoplasm
messages: Specifically catalyzes the removal of N-terminal proline residues from peptides.

243273:MG RS01020
gene id: 243273:MG_RS01020
uniprot id: P47429
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.

243273:MG RS00300
gene id: 243273:MG_RS00300
uniprot id: P47304
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
messages: Probably essential, it was not disrupted in a global transposon mutagenesis study.

243273:MG RS00160
gene id: 243273:MG_RS00160
uniprot id: P47278
names: Similarity
messages: Belongs to the MG032/MG096/MG288 family.

243273:MG RS01615
gene id: 243273:MG_RS01615
uniprot id: P47514
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Forms a 24-polypeptide structural core with octahedral symmetry.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).

243273:MG RS01365
gene id: 243273:MG_RS01365
uniprot id: P47474
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

243273:MG RS02160
gene id: 243273:MG_RS02160
uniprot id: P47593
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

243273:MG RS00835
gene id: 243273:MG_RS00835
uniprot id: Q49399
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0053 family.
messages: Cell membrane

243273:MG RS02495
gene id: 243273:MG_RS02495
uniprot id: P47653
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MG414/MG415 family.
messages: Cell membrane

243273:MG RS00430
gene id: 243273:MG_RS00430
uniprot id: P47322
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS00800
gene id: 243273:MG_RS00800
uniprot id: P47386
names: Similarity
messages: Belongs to the DNA2/NAM7 helicase family.

243273:MG RS01065
gene id: 243273:MG_RS01065
uniprot id: P47435
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell membrane
messages: Probably essential, it was not disrupted in a global transposon mutagenesis study.
messages: Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane.

243273:MG RS00400
gene id: 243273:MG_RS00400
uniprot id: P47316
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

243273:MG RS02710
gene id: 243273:MG_RS02710
uniprot id: P47698
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.

243273:MG RS02625
gene id: 243273:MG_RS02625
uniprot id: P47682
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

243273:MG RS01015
gene id: 243273:MG_RS01015
uniprot id: P47428
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.

243273:MG RS00740
gene id: 243273:MG_RS00740
uniprot id: P47382
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

243273:MG RS02500
gene id: 243273:MG_RS02500
uniprot id: P47655
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MG414/MG415 family.
messages: Cell membrane

243273:MG RS00280
gene id: 243273:MG_RS00280
uniprot id: P47301
names: Subcellular Location Annotation
messages: Membrane

243273:MG RS01505
gene id: 243273:MG_RS01505
uniprot id: P47499
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

243273:MG RS02465
gene id: 243273:MG_RS02465
uniprot id: P47647
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

243273:MG RS00175
gene id: 243273:MG_RS00175
uniprot id: P47281
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

243273:MG RS00155
gene id: 243273:MG_RS00155
uniprot id: P47277
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-C family. PolC subfamily.
messages: Cytoplasm
messages: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

243273:MG RS02570
gene id: 243273:MG_RS02570
uniprot id: Q49432
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS00805
gene id: 243273:MG_RS00805
uniprot id: P47387
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

243273:MG RS00030
gene id: 243273:MG_RS00030
uniprot id: P47252
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

243273:MG RS00245
gene id: 243273:MG_RS00245
uniprot id: P47294
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

243273:MG RS01160
gene id: 243273:MG_RS01160
uniprot id: P47447
names: Function
names: Similarity
messages: Belongs to the HrcA family.
messages: Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.

243273:MG RS00410
gene id: 243273:MG_RS00410
uniprot id: P47318
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

243273:MG RS00065
gene id: 243273:MG_RS00065
uniprot id: P47259
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Probably essential, it was not disrupted in a global transposon mutagenesis study.

243273:MG RS00675
gene id: 243273:MG_RS00675
uniprot id: P47370
names: Function
names: Similarity
messages: Belongs to the thioredoxin family.
messages: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.

243273:MG RS01055
gene id: 243273:MG_RS01055
uniprot id: P47433
names: Similarity
messages: Belongs to the ABC transporter superfamily.

243273:MG RS00925
gene id: 243273:MG_RS00925
uniprot id: P47409
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

243273:MG RS02240
gene id: 243273:MG_RS02240
uniprot id: P47605
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

243273:MG RS00045
gene id: 243273:MG_RS00045
uniprot id: P47255
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.
messages: Binds 2 divalent metal cations per subunit.

243273:MG RS01205
gene id: 243273:MG_RS01205
uniprot id: Q9ZB79
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

243273:MG RS00005
gene id: 243273:MG_RS00005
uniprot id: P47247
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA which binds and tethers DNA polymerases and other proteins to the DNA. The DNA replisome complex has a single clamp-loading complex (3 tau and 1 each of delta, delta', psi and chi subunits) which binds 3 Pol III cores (1 core on the leading strand and 2 on the lagging strand) each with a beta sliding clamp dimer. Additional proteins in the replisome are other copies of gamma, psi and chi, Ssb, DNA helicase and RNA primase.
messages: Probably essential, it was not disrupted in a global transposon mutagenesis study.

243273:MG RS01410
gene id: 243273:MG_RS01410
uniprot id: P47483
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS01375
gene id: 243273:MG_RS01375
uniprot id: P47476
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

243273:MG RS01855
gene id: 243273:MG_RS01855
uniprot id: Q49412
names: Similarity
messages: Belongs to the lipase/esterase LIP3/BchO family.

243273:MG RS01605
gene id: 243273:MG_RS01605
uniprot id: P47512
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LplA family.
messages: Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.
messages: Cytoplasm
messages: In the transfer reaction, the free carboxyl group of lipoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.

243273:MG RS02530
gene id: 243273:MG_RS02530
uniprot id: P47662
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS00700
gene id: 243273:MG_RS00700
uniprot id: Q49397
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain.
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

243273:MG RS02745
gene id: 243273:MG_RS02745
uniprot id: P47705
names: Similarity
messages: Belongs to the ABC transporter superfamily.

243273:MG RS02450
gene id: 243273:MG_RS02450
uniprot id: P47644
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: Dicyclohexylcarbodiimide (DCDD) binding to the active glutamate residue inhibits ATPase in vitro.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.

243273:MG RS01745
gene id: 243273:MG_RS01745
uniprot id: Q49410
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: P37 is part of a high-affinity transport system.

243273:MG RS02610
gene id: 243273:MG_RS02610
uniprot id: P47679
names: Subcellular Location Annotation
messages: Membrane

243273:MG RS01980
gene id: 243273:MG_RS01980
uniprot id: P47566
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M24B family.
messages: Binds 2 manganese ions per subunit.

243273:MG RS00395
gene id: 243273:MG_RS00395
uniprot id: P47315
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: The EIIA domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB domain.
messages: The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain.
messages: The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport.

243273:MG RS00975
gene id: 243273:MG_RS00975
uniprot id: P47419
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

243273:MG RS00305
gene id: 243273:MG_RS00305
uniprot id: P47305
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Essential, it cannot be deleted.
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

243273:MG RS00705
gene id: 243273:MG_RS00705
uniprot id: P47376
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

243273:MG RS00830
gene id: 243273:MG_RS00830
uniprot id: P47391
names: Function
names: Similarity
messages: Belongs to the RibF family.
messages: Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.

243273:MG RS01660
gene id: 243273:MG_RS01660
uniprot id: P47523
names: Subcellular Location Annotation
messages: Membrane

243273:MG RS00825
gene id: 243273:MG_RS00825
uniprot id: P47390
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS02770
gene id: 243273:MG_RS02770
uniprot id: P47706
names: Similarity
messages: Belongs to the ParA family.

243273:MG RS01180
gene id: 243273:MG_RS01180
uniprot id: P47451
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.

243273:MG RS02210
gene id: 243273:MG_RS02210
uniprot id: Q49425
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

243273:MG RS01985
gene id: 243273:MG_RS01985
uniprot id: P47567
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

243273:MG RS02430
gene id: 243273:MG_RS02430
uniprot id: P47640
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

243273:MG RS01610
gene id: 243273:MG_RS01610
uniprot id: P47513
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes.
messages: The active site is a redox-active disulfide bond.

243273:MG RS01345
gene id: 243273:MG_RS01345
uniprot id: P47470
names: Function
names: Similarity
messages: Belongs to the dihydrofolate reductase family.
messages: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).

243273:MG RS00980
gene id: 243273:MG_RS00980
uniprot id: P47421
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

243273:MG RS01645
gene id: 243273:MG_RS01645
uniprot id: P47520
names: Function
names: Similarity
messages: Belongs to the RelA/SpoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the degradation of ppGpp into GDP. It may also be capable of catalyzing the synthesis of ppGpp (By similarity).

243273:MG RS01380
gene id: 243273:MG_RS01380
uniprot id: P47477
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

243273:MG RS02275
gene id: 243273:MG_RS02275
uniprot id: P47612
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm

243273:MG RS00735
gene id: 243273:MG_RS00735
uniprot id: P47381
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS01750
gene id: 243273:MG_RS01750
uniprot id: P47532
names: Function
names: Similarity
messages: Belongs to the ABC transporter superfamily.
messages: Part of a high-affinity transport system.

243273:MG RS00750
gene id: 243273:MG_RS00750
uniprot id: P47384
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

243273:MG RS02155
gene id: 243273:MG_RS02155
uniprot id: Q9ZB72
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS00970
gene id: 243273:MG_RS00970
uniprot id: P47418
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

243273:MG RS01295
gene id: 243273:MG_RS01295
uniprot id: Q49403
names: Disruption Phenotype
names: Subcellular Location Annotation
messages: Cell membrane
messages: Not essential, it can be deleted.

243273:MG RS00215
gene id: 243273:MG_RS00215
uniprot id: P47289
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Required for the activity of the bacterial transport system of putrescine and spermidine.

243273:MG RS00755
gene id: 243273:MG_RS00755
uniprot id: P47385
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endoonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay (By similarity).
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Binds up to 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

243273:MG RS02305
gene id: 243273:MG_RS02305
uniprot id: P47618
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

243273:MG RS02715
gene id: 243273:MG_RS02715
uniprot id: P47699
names: Disruption Phenotype
messages: Probably essential, it was not disrupted in a global transposon mutagenesis study.

243273:MG RS02355
gene id: 243273:MG_RS02355
uniprot id: Q49429
names: Function
messages: Could be an accessory structural component in cytadherence.

243273:MG RS00190
gene id: 243273:MG_RS00190
uniprot id: P47284
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

243273:MG RS02515
gene id: 243273:MG_RS02515
uniprot id: P47658
names: Caution
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex (By similarity).
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
messages: Probably essential, it was not disrupted in a global transposon mutagenesis study.
messages: Was originally thought to be two separate ORFs named DnaX and DnaZ.

243273:MG RS00350
gene id: 243273:MG_RS00350
uniprot id: P47312
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

243273:MG RS00110
gene id: 243273:MG_RS00110
uniprot id: P47268
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RpoE family.
messages: Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity).
messages: RNAP is composed of a core of 2 alpha, a beta and a beta' subunits. The core is associated with a delta subunit and one of several sigma factors (By similarity).

243273:MG RS01280
gene id: 243273:MG_RS01280
uniprot id: P47460
names: Function
messages: Component of the cytoskeleton-like structure which stabilizes the shape of the wall-less Mycoplasma. This cytoskeleton-like network of accessory proteins containing HMW proteins 1 to 5 allows the proper anchoring of cytadhesin proteins in the mycoplasmal membrane at the attachment organelle (By similarity).

243273:MG RS01765
gene id: 243273:MG_RS01765
uniprot id: P47534
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

243273:MG RS02470
gene id: 243273:MG_RS02470
uniprot id: P47648
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Decreased agglutination to sheep erythrocytes and survival in hamster lungs and increased sensitivity to hydrogen peroxide.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).

243273:MG RS01050
gene id: 243273:MG_RS01050
uniprot id: P47432
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS00530
gene id: 243273:MG_RS00530
uniprot id: P47342
names: Similarity
messages: Belongs to the MG032/MG096/MG288 family.

243273:MG RS00130
gene id: 243273:MG_RS00130
uniprot id: P47272
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity).

243273:MG RS01025
gene id: 243273:MG_RS01025
uniprot id: Q49400
names: Function
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.
messages: Probably recognizes the double-stranded sequence 5'-CTAT-3' and methylates A-3 on only one strand; as the bacterial DNA is methylated on this sequence and this is the only type II methylase in the genome, it is probably responsible for all of the methylation on this site in the genome.

243273:MG RS00020
gene id: 243273:MG_RS00020
uniprot id: P47250
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

243273:MG RS01890
gene id: 243273:MG_RS01890
uniprot id: Q57081
names: Function
names: Subcellular Location Annotation
messages: Component of the cytoskeleton-like structure which stabilizes the shape of the wall-less mycoplasma. This cytoskeleton-like network of accessory proteins containing HMW proteins 1 to 5 allows the proper anchoring of cytadhesin proteins in the mycoplasmal membrane at the attachment organelle. Essential for successful surface parasitism (By similarity).
messages: attachment organelle membrane

243273:MG RS00915
gene id: 243273:MG_RS00915
uniprot id: P47407
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

243273:MG RS02445
gene id: 243273:MG_RS02445
uniprot id: P47643
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase B chain family.
messages: Cell membrane
messages: Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.

243273:MG RS02390
gene id: 243273:MG_RS02390
uniprot id: P47633
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

243273:MG RS02060
gene id: 243273:MG_RS02060
uniprot id: P47580
names: Disruption Phenotype
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MG307/MG309/MG338 family.
messages: Cell membrane
messages: Probably essential, it was not disrupted in a global transposon mutagenesis study.

243273:MG RS01640
gene id: 243273:MG_RS01640
uniprot id: Q49409
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS00260
gene id: 243273:MG_RS00260
uniprot id: P47297
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
messages: Homodimer.
messages: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.

243273:MG RS02505
gene id: 243273:MG_RS02505
uniprot id: P47656
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

243273:MG RS00325
gene id: 243273:MG_RS00325
uniprot id: P47308
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: The EIIC type-2 domain forms the PTS system translocation channel and contains the specific substrate-binding site.
messages: The PTS EIIA type-2 domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-2 domain.
messages: The PTS EIIB type-2 domain is phosphorylated by phospho-EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-2 domain.
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in fructose transport.

243273:MG RS00575
gene id: 243273:MG_RS00575
uniprot id: P47350
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.
messages: Belongs to the RNR ribonuclease family. RNase R subfamily.
messages: Cytoplasm

243273:MG RS01075
gene id: 243273:MG_RS01075
uniprot id: P20796
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adhesin P1 family.
messages: Cell membrane
messages: The protein is the major adhesin mediating the attachment of this mycoplasma to the ciliated epithelium.

243273:MG RS00550
gene id: 243273:MG_RS00550
uniprot id: P47346
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

243273:MG RS00015
gene id: 243273:MG_RS00015
uniprot id: P47249
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

243273:MG RS02480
gene id: 243273:MG_RS02480
uniprot id: P47650
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
messages: Cell membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

243273:MG RS02015
gene id: 243273:MG_RS02015
uniprot id: P47573
names: Subcellular Location Annotation
messages: Membrane

243273:MG RS01815
gene id: 243273:MG_RS01815
uniprot id: P47544
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CbiQ family.
messages: Cell membrane

243273:MG RS00165
gene id: 243273:MG_RS00165
uniprot id: P47279
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism.

243273:MG RS02700
gene id: 243273:MG_RS02700
uniprot id: P47696
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm
messages: Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi.

243273:MG RS02575
gene id: 243273:MG_RS02575
uniprot id: P47246
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity).
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

243273:MG RS00460
gene id: 243273:MG_RS00460
uniprot id: P47328
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

243273:MG RS01650
gene id: 243273:MG_RS01650
uniprot id: P47521
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS01150
gene id: 243273:MG_RS01150
uniprot id: P47445
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type II topoisomerase family. ParE type 2 subfamily.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

243273:MG RS02680
gene id: 243273:MG_RS02680
uniprot id: P47693
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.
messages: Probably essential, it was not disrupted in a global transposon mutagenesis study.

243273:MG RS00490
gene id: 243273:MG_RS00490
uniprot id: P47334
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

243273:MG RS01115
gene id: 243273:MG_RS01115
uniprot id: P47439
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

243273:MG RS01415
gene id: 243273:MG_RS01415
uniprot id: P47484
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS01165
gene id: 243273:MG_RS01165
uniprot id: P47448
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

243273:MG RS01895
gene id: 243273:MG_RS01895
uniprot id: Q49417
names: Function
names: Subcellular Location Annotation
messages: Adhesin necessary for successful cytadherence and virulence.
messages: attachment organelle membrane

243273:MG RS01120
gene id: 243273:MG_RS01120
uniprot id: P47440
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity).

243273:MG RS00690
gene id: 243273:MG_RS00690
uniprot id: P47373
names: Similarity
messages: Belongs to the ArsC family.

243273:MG RS02360
gene id: 243273:MG_RS02360
uniprot id: P47627
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

243273:MG RS01865
gene id: 243273:MG_RS01865
uniprot id: Q49413
names: Function
names: Subcellular Location Annotation
messages: Component of the cytoskeleton-like structure which stabilizes the shape of the wall-less Mycoplasma. This cytoskeleton-like network of accessory proteins containing HMW proteins 1 to 5 allows the proper anchoring of cytadhesin proteins in the mycoplasmal membrane at the attachment organelle (By similarity).
messages: attachment organelle membrane

243273:MG RS00525
gene id: 243273:MG_RS00525
uniprot id: P47341
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS01695
gene id: 243273:MG_RS01695
uniprot id: P47525
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

243273:MG RS02845
gene id: 243273:MG_RS02845
uniprot id: P47603
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

243273:MG RS01460
gene id: 243273:MG_RS01460
uniprot id: P47493
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

243273:MG RS00080
gene id: 243273:MG_RS00080
uniprot id: P47260
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane

243273:MG RS01845
gene id: 243273:MG_RS01845
uniprot id: P52271
names: Similarity
messages: Belongs to the DEAD box helicase family.

243273:MG RS00115
gene id: 243273:MG_RS00115
uniprot id: P47269
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class II fructose-bisphosphate aldolase family.
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.
messages: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
messages: Homodimer.

243273:MG RS01395
gene id: 243273:MG_RS01395
uniprot id: P47480
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity).

243273:MG RS02115
gene id: 243273:MG_RS02115
uniprot id: P47588
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm

243273:MG RS01990
gene id: 243273:MG_RS01990
uniprot id: P47568
names: Function
messages: May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.

243273:MG RS00630
gene id: 243273:MG_RS00630
uniprot id: P47361
names: Similarity
messages: Belongs to the CinA family.

243273:MG RS00615
gene id: 243273:MG_RS00615
uniprot id: P47358
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

243273:MG RS01000
gene id: 243273:MG_RS01000
uniprot id: P47425
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).

243273:MG RS00285
gene id: 243273:MG_RS00285
uniprot id: Q9ZB81
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS01030
gene id: 243273:MG_RS01030
uniprot id: P47431
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MG185/MG260 family.
messages: Cell membrane

243273:MG RS01580
gene id: 243273:MG_RS01580
uniprot id: P47508
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

243273:MG RS00450
gene id: 243273:MG_RS00450
uniprot id: P47326
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system (By similarity).

243273:MG RS01325
gene id: 243273:MG_RS01325
uniprot id: P47467
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To M.genitalium MG226.

243273:MG RS00040
gene id: 243273:MG_RS00040
uniprot id: P47254
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.

243273:MG RS00655
gene id: 243273:MG_RS00655
uniprot id: P47366
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS02605
gene id: 243273:MG_RS02605
uniprot id: P47678
names: Disruption Phenotype
names: Miscellaneous
names: Similarity
messages: Although suggested to be a lipoprotein it does not have a good signal sequence.
messages: Belongs to the MG439/MG440 family.
messages: Probably essential, it was not disrupted in a global transposon mutagenesis study.

243273:MG RS01465
gene id: 243273:MG_RS01465
uniprot id: P47494
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

243273:MG RS01105
gene id: 243273:MG_RS01105
uniprot id: P47437
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

243273:MG RS02545
gene id: 243273:MG_RS02545
uniprot id: P47666
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OsmC/Ohr family.
messages: Cytoplasm
messages: Down-regulated by osmotic shock and ethanol. Not induced by oxidative stress.
messages: Homodimer.
messages: Mutant is highly sensitive to killing by tert-butyl hydroperoxide (t-BHP) and H(2)O(2).
messages: Reduces organic and inorganic peroxide substrates. Protects the cell against oxidative stress.

243273:MG RS02215
gene id: 243273:MG_RS02215
uniprot id: Q49426
names: Similarity
messages: Belongs to the DNA polymerase type-Y family.

243273:MG RS00455
gene id: 243273:MG_RS00455
uniprot id: P47327
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

243273:MG RS00295
gene id: 243273:MG_RS00295
uniprot id: P47303
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribonuclease M5 family.
messages: Binds two Mg(2+) per subunit.
messages: Cytoplasm
messages: Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity).

243273:MG RS02455
gene id: 243273:MG_RS02455
uniprot id: P47645
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.

243273:MG RS00865
gene id: 243273:MG_RS00865
uniprot id: P47397
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

243273:MG RS00875
gene id: 243273:MG_RS00875
uniprot id: P47399
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

243273:MG RS01560
gene id: 243273:MG_RS01560
uniprot id: P55825
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).
messages: Monomer.

243273:MG RS00900
gene id: 243273:MG_RS00900
uniprot id: P47404
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

243273:MG RS02105
gene id: 243273:MG_RS02105
uniprot id: Q49421
names: Similarity
messages: Belongs to the lipase/esterase LIP3/BchO family.

243273:MG RS00995
gene id: 243273:MG_RS00995
uniprot id: P47424
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

243273:MG RS02085
gene id: 243273:MG_RS02085
uniprot id: P47582
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Probably essential, it was not disrupted in a global transposon mutagenesis study.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

243273:MG RS00025
gene id: 243273:MG_RS00025
uniprot id: P47251
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

243273:MG RS00820
gene id: 243273:MG_RS00820
uniprot id: P47389
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

243273:MG RS01435
gene id: 243273:MG_RS01435
uniprot id: P47488
names: Similarity
messages: Belongs to the YmdB-like family.

243273:MG RS02685
gene id: 243273:MG_RS02685
uniprot id: P47694
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS01225
gene id: 243273:MG_RS01225
uniprot id: P47457
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphofructokinase type A (PFKA) family.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.

243273:MG RS01835
gene id: 243273:MG_RS01835
uniprot id: P47548
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS02590
gene id: 243273:MG_RS02590
uniprot id: Q49433
names: Disruption Phenotype
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Cell membrane
messages: Not essential, it can be deleted.

243273:MG RS00695
gene id: 243273:MG_RS00695
uniprot id: P47374
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

243273:MG RS02750
gene id: 243273:MG_RS02750
uniprot id: Q49460
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family.
messages: Cell membrane

243273:MG RS01445
gene id: 243273:MG_RS01445
uniprot id: P47490
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TrmK family.
messages: Cytoplasm

243273:MG RS01760
gene id: 243273:MG_RS01760
uniprot id: Q9ZB76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YqgF nuclease family.
messages: Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
messages: Cytoplasm

243273:MG RS01830
gene id: 243273:MG_RS01830
uniprot id: P47547
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock (By similarity).

243273:MG RS01210
gene id: 243273:MG_RS01210
uniprot id: Q49402
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

243273:MG RS00255
gene id: 243273:MG_RS00255
uniprot id: P47296
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

243273:MG RS02110
gene id: 243273:MG_RS02110
uniprot id: P47587
names: Cofactor
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.
messages: Probably essential, it was not disrupted in a global transposon mutagenesis study.

243273:MG RS01500
gene id: 243273:MG_RS01500
uniprot id: P47498
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS01360
gene id: 243273:MG_RS01360
uniprot id: P47473
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
messages: Tetramer of two alpha and two beta subunits.
messages: Under complex allosteric control mediated by deoxynucleoside triphosphates and ATP binding. The type of nucleotide bound at the specificity site determines substrate preference. It seems probable that ATP makes the enzyme reduce CDP and UDP, dGTP favors ADP reduction and dTTP favors GDP reduction (By similarity).

243273:MG RS00105
gene id: 243273:MG_RS00105
uniprot id: P47267
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Monomer.

243273:MG RS02630
gene id: 243273:MG_RS02630
uniprot id: P47683
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

243273:MG RS02065
gene id: 243273:MG_RS02065
uniprot id: P47581
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

243273:MG RS01010
gene id: 243273:MG_RS01010
uniprot id: P47427
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CbiQ family.
messages: Cell membrane

243273:MG RS01635
gene id: 243273:MG_RS01635
uniprot id: P47518
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

243273:MG RS02565
gene id: 243273:MG_RS02565
uniprot id: P47670
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

243273:MG RS00090
gene id: 243273:MG_RS00090
uniprot id: P47264
names: Disruption Phenotype
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Not essential, it can be deleted.

243273:MG RS00855
gene id: 243273:MG_RS00855
uniprot id: Q9ZB80
names: Disruption Phenotype
names: Subcellular Location Annotation
messages: Cell membrane
messages: Not essential, it can be deleted.

243273:MG RS02005
gene id: 243273:MG_RS02005
uniprot id: P47571
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

243273:MG RS00470
gene id: 243273:MG_RS00470
uniprot id: P47330
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

243273:MG RS02335
gene id: 243273:MG_RS02335
uniprot id: P47623
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

243273:MG RS02315
gene id: 243273:MG_RS02315
uniprot id: P47620
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

243273:MG RS00610
gene id: 243273:MG_RS00610
uniprot id: P47357
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

243273:MG RS02165
gene id: 243273:MG_RS02165
uniprot id: Q49422
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecU family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity).

243273:MG RS00965
gene id: 243273:MG_RS00965
uniprot id: P47417
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.
messages: Cytoplasm
messages: Monomer.

243273:MG RS02725
gene id: 243273:MG_RS02725
uniprot id: P47701
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

243273:MG RS00815
gene id: 243273:MG_RS00815
uniprot id: P47388
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity).

243273:MG RS02560
gene id: 243273:MG_RS02560
uniprot id: P47669
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.
messages: Probably essential, it was not disrupted in a global transposon mutagenesis study.

243273:MG RS02410
gene id: 243273:MG_RS02410
uniprot id: P47636
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LacAB/RpiB family.
messages: Catalyzes the interconversion of ribulose-5-P and ribose-5-P.
messages: Homodimer.

243273:MG RS00315
gene id: 243273:MG_RS00315
uniprot id: P47307
names: Disruption Phenotype
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Cell membrane
messages: Not essential, it can be deleted.

243273:MG RS00880
gene id: 243273:MG_RS00880
uniprot id: P47400
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

243273:MG RS00270
gene id: 243273:MG_RS00270
uniprot id: P47299
names: Cofactor
names: Similarity
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.

243273:MG RS02755
gene id: 243273:MG_RS02755
uniprot id: Q9ZB70
names: Similarity
messages: Belongs to the ABC transporter superfamily.

243273:MG RS02265
gene id: 243273:MG_RS02265
uniprot id: P47610
names: Similarity
messages: Belongs to the pseudouridine synthase RluA family.

243273:MG RS01585
gene id: 243273:MG_RS01585
uniprot id: P47509
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS02510
gene id: 243273:MG_RS02510
uniprot id: P47657
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

243273:MG RS00205
gene id: 243273:MG_RS00205
uniprot id: P47287
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HPr family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.
messages: P-Ser-HPr interacts with the catabolite control protein A (CcpA), forming a complex that binds to DNA at the catabolite response elements cre, operator sites preceding a large number of catabolite-regulated genes. Thus, P-Ser-HPr is a corepressor in carbon catabolite repression (CCR), a mechanism that allows bacteria to coordinate and optimize the utilization of available carbon sources. P-Ser-HPr also plays a role in inducer exclusion, in which it probably interacts with several non-PTS permeases and inhibits their transport activity (By similarity).
messages: Phosphorylation on Ser-47 inhibits the phosphoryl transfer from enzyme I to HPr.

243273:MG RS00440
gene id: 243273:MG_RS00440
uniprot id: P47324
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily.
messages: Cell membrane
messages: Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane.

243273:MG RS02270
gene id: 243273:MG_RS02270
uniprot id: Q49428
names: Similarity
messages: Belongs to the mgp1/MG371 family.

243273:MG RS02485
gene id: 243273:MG_RS02485
uniprot id: P47651
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Could be part of a binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.

243273:MG RS00545
gene id: 243273:MG_RS00545
uniprot id: P47345
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

243273:MG RS00265
gene id: 243273:MG_RS00265
uniprot id: P47298
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: Binds 1 zinc ion.
messages: Homodimer.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

243273:MG RS00095
gene id: 243273:MG_RS00095
uniprot id: P47265
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

243273:MG RS02555
gene id: 243273:MG_RS02555
uniprot id: P47668
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
messages: Homodimer.
messages: The N-terminal domain contains the HPr binding site, the central domain the pyrophosphate/phosphate carrier histidine, and the C-terminal domain the pyruvate binding site.
messages: The reaction takes place in three steps, mediated by a phosphocarrier histidine residue located on the surface of the central domain. The two first partial reactions are catalyzed at an active site located on the N-terminal domain, and the third partial reaction is catalyzed at an active site located on the C-terminal domain. For catalytic turnover, the central domain swivels from the concave surface of the N-terminal domain to that of the C-terminal domain.

243273:MG RS01690
gene id: 243273:MG_RS01690
uniprot id: P47524
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

243273:MG RS01005
gene id: 243273:MG_RS01005
uniprot id: P47426
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).

243273:MG RS02720
gene id: 243273:MG_RS02720
uniprot id: P47700
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

243273:MG RS00885
gene id: 243273:MG_RS00885
uniprot id: P47401
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

243273:MG RS01800
gene id: 243273:MG_RS01800
uniprot id: P47541
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: Cytoplasm

243273:MG RS02620
gene id: 243273:MG_RS02620
uniprot id: P47681
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS00910
gene id: 243273:MG_RS00910
uniprot id: P47406
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

243273:MG RS02340
gene id: 243273:MG_RS02340
uniprot id: P47624
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

243273:MG RS02675
gene id: 243273:MG_RS02675
uniprot id: P47692
names: Similarity
messages: Belongs to the OsmC/Ohr family.

243273:MG RS02540
gene id: 243273:MG_RS02540
uniprot id: P47664
names: Similarity
messages: Belongs to the DEAD box helicase family.

243273:MG RS01575
gene id: 243273:MG_RS01575
uniprot id: P47507
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. Cof family.

243273:MG RS02225
gene id: 243273:MG_RS02225
uniprot id: P36255
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

243273:MG RS01825
gene id: 243273:MG_RS01825
uniprot id: P47546
names: Disruption Phenotype
names: Similarity
messages: Belongs to the ABC transporter superfamily.
messages: Probably essential, it was not disrupted in a global transposon mutagenesis study.

243273:MG RS01370
gene id: 243273:MG_RS01370
uniprot id: P47475
names: Similarity
names: Subcellular Location Annotation
messages: Membrane
messages: To B.subtilis YsxB.

243273:MG RS01820
gene id: 243273:MG_RS01820
uniprot id: P47545
names: Similarity
messages: Belongs to the ABC transporter superfamily.

243273:MG RS02415
gene id: 243273:MG_RS02415
uniprot id: P47637
names: Subcellular Location Annotation
messages: Membrane

243273:MG RS02660
gene id: 243273:MG_RS02660
uniprot id: P13927
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

243273:MG RS00010
gene id: 243273:MG_RS00010
uniprot id: P47248
names: Disruption Phenotype
messages: Not essential, it can be deleted.

243273:MG RS01625
gene id: 243273:MG_RS01625
uniprot id: P47516
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).

243273:MG RS00485
gene id: 243273:MG_RS00485
uniprot id: P47333
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Because the enzyme that would modify Asp-102 to 3-methylthioaspartic acid has not been found in the proteome of this organism, that modification is not predicted.
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

243273:MG RS02435
gene id: 243273:MG_RS02435
uniprot id: P47641
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

243273:MG RS01305
gene id: 243273:MG_RS01305
uniprot id: P47463
names: Disruption Phenotype
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: Probably essential, it was not disrupted in a global transposon mutagenesis study.
messages: nucleoid

243273:MG RS02120
gene id: 243273:MG_RS02120
uniprot id: P47589
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.

243273:MG RS01655
gene id: 243273:MG_RS01655
uniprot id: P47522
names: Disruption Phenotype
names: Subcellular Location Annotation
messages: Cell membrane
messages: Not essential, it can be deleted.

243273:MG RS02400
gene id: 243273:MG_RS02400
uniprot id: P47635
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MG067/MG068/MG395 family.
messages: Cell membrane

243273:MG RS01060
gene id: 243273:MG_RS01060
uniprot id: P47434
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell membrane
messages: Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane.

243273:MG RS00310
gene id: 243273:MG_RS00310
uniprot id: P47306
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

243273:MG RS00605
gene id: 243273:MG_RS00605
uniprot id: P47356
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.

243273:MG RS02130
gene id: 243273:MG_RS02130
uniprot id: P47590
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS02190
gene id: 243273:MG_RS02190
uniprot id: P47599
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

243273:MG RS01310
gene id: 243273:MG_RS01310
uniprot id: P47464
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

243273:MG RS00330
gene id: 243273:MG_RS00330
uniprot id: Q49396
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.
messages: Not essential, it can be deleted.

243273:MG RS00645
gene id: 243273:MG_RS00645
uniprot id: P47364
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.
messages: Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).

243273:MG RS01570
gene id: 243273:MG_RS01570
uniprot id: P47506
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

243273:MG RS01450
gene id: 243273:MG_RS01450
uniprot id: P47491
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

243273:MG RS02595
gene id: 243273:MG_RS02595
uniprot id: Q49434
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.
messages: Contains two target DNA recognition domains (TRD), each specifying recognition of one of the two defined components of the target sequence (Probable). The TDRs show high structural similarity and each forms a globular structure. The two TDRs are separated by 2 long, conserved antiparallel helices that form a coiled coil structure (PubMed:16038930).
messages: Not essential, it can be deleted.
messages: The specificity (S) subunit of a type I restriction enzyme; this subunit dictates DNA sequence specificity. This bacterium does not encode the associated endonuclease or methylase subunits.

243273:MG RS02805
gene id: 243273:MG_RS02805
uniprot id: P47420
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

243273:MG RS00945
gene id: 243273:MG_RS00945
uniprot id: P47413
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

243273:MG RS02050
gene id: 243273:MG_RS02050
uniprot id: Q49420
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.
messages: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.

243273:MG RS02035
gene id: 243273:MG_RS02035
uniprot id: P47577
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

243273:MG RS02220
gene id: 243273:MG_RS02220
uniprot id: P36263
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex (By similarity).

243273:MG RS01860
gene id: 243273:MG_RS01860
uniprot id: P47553
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

243273:MG RS02365
gene id: 243273:MG_RS02365
uniprot id: P47628
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Probably essential, it was not disrupted in a global transposon mutagenesis study.
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

243273:MG RS02640
gene id: 243273:MG_RS02640
uniprot id: P47685
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS00140
gene id: 243273:MG_RS00140
uniprot id: P47274
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS02205
gene id: 243273:MG_RS02205
uniprot id: Q49424
names: Disruption Phenotype
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Not essential, it can be deleted.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

243273:MG RS00860
gene id: 243273:MG_RS00860
uniprot id: P47396
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

243273:MG RS00850
gene id: 243273:MG_RS00850
uniprot id: P47395
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS01790
gene id: 243273:MG_RS01790
uniprot id: P47539
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

243273:MG RS00935
gene id: 243273:MG_RS00935
uniprot id: P47411
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

243273:MG RS00230
gene id: 243273:MG_RS00230
uniprot id: P47292
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

243273:MG RS02255
gene id: 243273:MG_RS02255
uniprot id: Q49427
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

243273:MG RS00665
gene id: 243273:MG_RS00665
uniprot id: P47368
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Binds two Mg(2+) per subunit.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

243273:MG RS00495
gene id: 243273:MG_RS00495
uniprot id: P47335
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).
messages: Cytoplasm

243273:MG RS00445
gene id: 243273:MG_RS00445
uniprot id: P47325
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system (By similarity).

243273:MG RS02600
gene id: 243273:MG_RS02600
uniprot id: P47677
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MG439/MG440 family.
messages: Cell membrane

243273:MG RS01405
gene id: 243273:MG_RS01405
uniprot id: P47482
names: Disruption Phenotype
names: Function
names: Similarity
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
messages: Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) to yield ADP.
messages: In the C-terminal section; belongs to the Ap4A hydrolase YqeK family.
messages: In the N-terminal section; belongs to the NadD family.
messages: Probably essential, it was not disrupted in a global transposon mutagenesis study.

243273:MG RS00220
gene id: 243273:MG_RS00220
uniprot id: P47290
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Required for the activity of the bacterial transport system of putrescine and spermidine.

243273:MG RS00840
gene id: 243273:MG_RS00840
uniprot id: P47393
names: Disruption Phenotype
names: Subcellular Location Annotation
messages: Cell membrane
messages: Probably essential, it was not disrupted in a global transposon mutagenesis study.

243273:MG RS01805
gene id: 243273:MG_RS01805
uniprot id: P47542
names: Disruption Phenotype
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Monomer.
messages: Probably essential, it was not disrupted in a global transposon mutagenesis study.

243273:MG RS00955
gene id: 243273:MG_RS00955
uniprot id: P47415
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

243273:MG RS00870
gene id: 243273:MG_RS00870
uniprot id: P47398
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

243273:MG RS00570
gene id: 243273:MG_RS00570
uniprot id: P58061
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation (By similarity).

243273:MG RS00340
gene id: 243273:MG_RS00340
uniprot id: P47310
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-4 integral membrane protein family.
messages: Cell membrane

243273:MG RS00200
gene id: 243273:MG_RS00200
uniprot id: P47286
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To T.pallidum TmpC.

243273:MG RS00060
gene id: 243273:MG_RS00060
uniprot id: P47258
names: Similarity
messages: Belongs to the RimK family.

243273:MG RS00235
gene id: 243273:MG_RS00235
uniprot id: P47293
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

243273:MG RS02290
gene id: 243273:MG_RS02290
uniprot id: P47615
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.

243273:MG RS00565
gene id: 243273:MG_RS00565
uniprot id: P47349
names: Function
names: Similarity
messages: Belongs to the WhiA family.
messages: Involved in cell division and chromosome segregation.

243273:MG RS00275
gene id: 243273:MG_RS00275
uniprot id: P47300
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

243273:MG RS02730
gene id: 243273:MG_RS02730
uniprot id: P47702
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration (By similarity).
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins (By similarity).

243273:MG RS01520
gene id: 243273:MG_RS01520
uniprot id: P47502
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MG185/MG260 family.
messages: Cell membrane

243273:MG RS00985
gene id: 243273:MG_RS00985
uniprot id: P47422
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.
messages: Probably essential, it was not disrupted in a global transposon mutagenesis study.

243273:MG RS01100
gene id: 243273:MG_RS01100
uniprot id: P47436
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

243273:MG RS01905
gene id: 243273:MG_RS01905
uniprot id: P47562
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS02045
gene id: 243273:MG_RS02045
uniprot id: Q9ZB73
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Activated by the negatively charged lipid dioleoylphosphatidylglycerol (DOPG) and inhibited by N-(n-nonyl)deoxygalactonojirimycin (C9J).
messages: Belongs to the glycosyltransferase 2 family.
messages: Cell membrane
messages: Processive glycosyltransferase involved in the biosynthesis of both the non-bilayer-prone beta-monoglycosyldiacylglycerol and the bilayer-forming membrane lipid beta-diglycosyldiacylglycerol. These components contribute to regulate the properties and stability of the membrane. Catalyzes sequentially the transfers of glucosyl or galactosyl residues from UDP-Glc or UDP-Gal to diacylglycerol (DAG) acceptor to form the corresponding beta-glycosyl-DAG (3-O-(beta-D-glycopyranosyl)-1,2-diacyl-sn-glycerol), which then acts as acceptor to give beta-diglycosyl-DAG product (3-O-(beta-D-glycopyranosyl-beta-(1->6)-D-glycopyranosyl)-1,2-diacyl-sn-glycerol). Dioleoylglycerol (DOG) is a preferred sugar acceptor than 3-O-(beta-D-glucopyranosyl)-1,2-dioleoyl-sn-glycerol.
messages: The local lipid environment around the enzyme affects both the extent of head group elongation and total amounts of glycolipids produced.

243273:MG RS02535
gene id: 243273:MG_RS02535
uniprot id: P47663
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

243273:MG RS01630
gene id: 243273:MG_RS01630
uniprot id: Q49408
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Catalyzes the four-electron reduction of molecular oxygen to water.
messages: Probably essential, it was not disrupted in a global transposon mutagenesis study.

243273:MG RS01770
gene id: 243273:MG_RS01770
uniprot id: P47535
names: Similarity
messages: To M.genitalium MG385.
messages: To glycerophosphoryl diester phosphodiesterases (EC 3.1.4.46).

243273:MG RS00210
gene id: 243273:MG_RS00210
uniprot id: P47288
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Cell membrane
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

243273:MG RS00560
gene id: 243273:MG_RS00560
uniprot id: P47348
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: The active site is a redox-active disulfide bond.

243273:MG RS02695
gene id: 243273:MG_RS02695
uniprot id: P47695
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

243273:MG RS02310
gene id: 243273:MG_RS02310
uniprot id: P47619
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

243273:MG RS02020
gene id: 243273:MG_RS02020
uniprot id: P47574
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

243273:MG RS00475
gene id: 243273:MG_RS00475
uniprot id: P47331
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HPrK/P family.
messages: Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.
messages: Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr) (By similarity).
messages: Homohexamer.
messages: The Walker A ATP-binding motif also binds Pi and PPi.

243273:MG RS00500
gene id: 243273:MG_RS00500
uniprot id: P47336
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

243273:MG RS00600
gene id: 243273:MG_RS00600
uniprot id: P47355
names: Disruption Phenotype
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cell membrane
messages: Probably essential, it was not disrupted in a global transposon mutagenesis study.

243273:MG RS02090
gene id: 243273:MG_RS02090
uniprot id: P47583
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

243273:MG RS00345
gene id: 243273:MG_RS00345
uniprot id: P47311
names: Similarity
messages: Belongs to the ABC transporter superfamily.

243273:MG RS02180
gene id: 243273:MG_RS02180
uniprot id: P47597
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent (By similarity).
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
messages: The N-terminal domain probably functions as a substrate-discriminating domain, recruiting aggregated proteins to the ClpB hexamer and/or stabilizing bound proteins. The NBD2 domain is responsible for oligomerization, whereas the NBD1 domain stabilizes the hexamer probably in an ATP-dependent manner. The movement of the coiled-coil domain is essential for ClpB ability to rescue proteins from an aggregated state, probably by pulling apart large aggregated proteins, which are bound between the coiled-coils motifs of adjacent ClpB subunits in the functional hexamer (By similarity).

243273:MG RS01710
gene id: 243273:MG_RS01710
uniprot id: P47528
names: Subcellular Location Annotation
messages: Membrane

243273:MG RS01425
gene id: 243273:MG_RS01425
uniprot id: P47486
names: Function
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.
messages: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair (By similarity).

243273:MG RS01215
gene id: 243273:MG_RS01215
uniprot id: P47455
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ScpA family.
messages: Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA (By similarity).
messages: Cytoplasm
messages: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity).

243273:MG RS00290
gene id: 243273:MG_RS00290
uniprot id: P47302
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

243273:MG RS01430
gene id: 243273:MG_RS01430
uniprot id: P47487
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.
messages: Cytoplasm
messages: Involved in folate metabolism. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate (By similarity).
messages: Monomer or homodimer.

243273:MG RS01565
gene id: 243273:MG_RS01565
uniprot id: P47505
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. Cof family.

243273:MG RS00950
gene id: 243273:MG_RS00950
uniprot id: P47414
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

243273:MG RS01070
gene id: 243273:MG_RS01070
uniprot id: P22746
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the NrnA oligoribonuclease family.
messages: Bifunctional enzyme which has both oligoribonuclease and pAp-phosphatase activities. Degrades RNA and DNA oligonucleotides with a length of 5 nucleotides and shorter, with a preference for longer oligomers. Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP (By similarity).
messages: Probably essential, it was not disrupted in a global transposon mutagenesis study.

243273:MG RS00425
gene id: 243273:MG_RS00425
uniprot id: P47321
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS02010
gene id: 243273:MG_RS02010
uniprot id: P47572
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

243273:MG RS00670
gene id: 243273:MG_RS00670
uniprot id: P47369
names: Subcellular Location Annotation
messages: Membrane

243273:MG RS00930
gene id: 243273:MG_RS00930
uniprot id: P47410
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

243273:MG RS00465
gene id: 243273:MG_RS00465
uniprot id: P47329
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

243273:MG RS00520
gene id: 243273:MG_RS00520
uniprot id: P47340
names: Disruption Phenotype
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.
messages: Probably essential, it was not disrupted in a global transposon mutagenesis study.

243273:MG RS01340
gene id: 243273:MG_RS01340
uniprot id: P47469
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

243273:MG RS02655
gene id: 243273:MG_RS02655
uniprot id: P47688
names: Disruption Phenotype
names: Function
messages: May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.
messages: Probably essential, it was not disrupted in a global transposon mutagenesis study.

243273:MG RS02030
gene id: 243273:MG_RS02030
uniprot id: P47576
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

243273:MG RS02760
gene id: 243273:MG_RS02760
uniprot id: P35888
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).

243273:MG RS01440
gene id: 243273:MG_RS01440
uniprot id: P47489
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

243273:MG RS00890
gene id: 243273:MG_RS00890
uniprot id: P47402
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).

243273:MG RS01220
gene id: 243273:MG_RS01220
uniprot id: P47456
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ScpB family.
messages: Cytoplasm
messages: Homodimer. Homodimerization may be required to stabilize the binding of ScpA to the Smc head domains. Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.
messages: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.

243273:MG RS02740
gene id: 243273:MG_RS02740
uniprot id: P47704
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

243273:MG RS01900
gene id: 243273:MG_RS01900
uniprot id: P47561
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS02330
gene id: 243273:MG_RS02330
uniprot id: P47622
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

243273:MG RS00170
gene id: 243273:MG_RS00170
uniprot id: P47280
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidine kinase family.
messages: Cytoplasm
messages: Homotetramer.

243273:MG RS02585
gene id: 243273:MG_RS02585
uniprot id: P47673
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

243273:MG RS02375
gene id: 243273:MG_RS02375
uniprot id: Q49430
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane

243273:MG RS01620
gene id: 243273:MG_RS01620
uniprot id: P47515
names: Function
names: Subunit
messages: Heterodimer of an alpha and a beta chain.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).

243273:MG RS00150
gene id: 243273:MG_RS00150
uniprot id: P47276
names: Activity Regulation
names: Cofactor
names: Function
names: Similarity
messages: Allosterically activated by GTP.
messages: Belongs to the UPRTase family.
messages: Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
messages: Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

243273:MG RS02025
gene id: 243273:MG_RS02025
uniprot id: P47575
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
messages: Belongs to the azoreductase type 1 family.
messages: Binds 1 FMN per subunit.
messages: Homodimer.
messages: Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.

243273:MG RS00085
gene id: 243273:MG_RS00085
uniprot id: P47261
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane

243273:MG RS01795
gene id: 243273:MG_RS01795
uniprot id: P47540
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible SMC hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

243273:MG RS01330
gene id: 243273:MG_RS01330
uniprot id: P47468
names: Disruption Phenotype
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: Not essential, it can be deleted.
messages: To M.genitalium MG225.

243273:MG RS00415
gene id: 243273:MG_RS00415
uniprot id: P47319
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

243273:MG RS01995
gene id: 243273:MG_RS01995
uniprot id: Q49418
names: Similarity
messages: Belongs to the lipase/esterase LIP3/BchO family.

243273:MG RS00360
gene id: 243273:MG_RS00360
uniprot id: P47314
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MG067/MG068/MG395 family.
messages: Cell membrane

243273:MG RS01840
gene id: 243273:MG_RS01840
uniprot id: P47549
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MG307/MG309/MG338 family.
messages: Cell membrane

243273:MG RS02440
gene id: 243273:MG_RS02440
uniprot id: P47642
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity).
messages: F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains (By similarity).
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction (By similarity).

243273:MG RS01355
gene id: 243273:MG_RS01355
uniprot id: P47472
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

243273:MG RS00120
gene id: 243273:MG_RS00120
uniprot id: P47270
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

243273:MG RS01195
gene id: 243273:MG_RS01195
uniprot id: P57085
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

243273:MG RS00540
gene id: 243273:MG_RS00540
uniprot id: P47344
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: In the C-terminal section; belongs to the GatC family.

243273:MG RS02580
gene id: 243273:MG_RS02580
uniprot id: P47672
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.

243273:MG RS00580
gene id: 243273:MG_RS00580
uniprot id: P47351
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate cyclase family. DacB/CdaS subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Cell membrane
messages: Probably essential, it was not disrupted in a global transposon mutagenesis study.
messages: Probably oligomerizes.

243273:MG RS00990
gene id: 243273:MG_RS00990
uniprot id: P47423
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

243273:MG RS02370
gene id: 243273:MG_RS02370
uniprot id: P47629
names: Subcellular Location Annotation
messages: Membrane

243273:MG RS02040
gene id: 243273:MG_RS02040
uniprot id: Q49310
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0154 family.
messages: Membrane

243273:MG RS01810
gene id: 243273:MG_RS01810
uniprot id: P47543
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
messages: Cytoplasm
messages: Homotetramer.

243273:MG RS00660
gene id: 243273:MG_RS00660
uniprot id: P47367
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS00480
gene id: 243273:MG_RS00480
uniprot id: P47332
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

243273:MG RS01230
gene id: 243273:MG_RS01230
uniprot id: P47458
names: Activity Regulation
names: Similarity
names: Subunit
messages: Belongs to the pyruvate kinase family.
messages: Homotetramer.
messages: Regulated by phosphoenolpyruvate substrate and is allosterically activated by ribose-5-phosphate, AMP and other nucleoside monophosphates but not by fructose-1,6-bisphosphate.

243273:MG RS01110
gene id: 243273:MG_RS01110
uniprot id: P47438
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

243273:MG RS01510
gene id: 243273:MG_RS01510
uniprot id: P47500
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1 (By similarity).
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

243273:MG RS01550
gene id: 243273:MG_RS01550
uniprot id: Q49405
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-C family. DnaE subfamily.
messages: Cytoplasm
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the PolIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex (By similarity).
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity).

243273:MG RS01185
gene id: 243273:MG_RS01185
uniprot id: Q49401
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

243273:MG RS00620
gene id: 243273:MG_RS00620
uniprot id: P47359
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

243273:MG RS00680
gene id: 243273:MG_RS00680
uniprot id: P47371
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. Cof family.

243273:MG RS00650
gene id: 243273:MG_RS00650
uniprot id: P47365
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Part of the ABC transporter complex involved in carbohydrates import. Probably responsible for energy coupling to the transport system (By similarity).

243273:MG RS02230
gene id: 243273:MG_RS02230
uniprot id: P55750
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

243273:MG RS00225
gene id: 243273:MG_RS00225
uniprot id: P47291
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS01455
gene id: 243273:MG_RS01455
uniprot id: P47492
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Binds two Mg(2+) per subunit.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

243273:MG RS01755
gene id: 243273:MG_RS01755
uniprot id: P47533
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Composed of two homologous domains.
messages: Probably part of a high-affinity transport system.

243273:MG RS01135
gene id: 243273:MG_RS01135
uniprot id: P47443
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

243273:MG RS01400
gene id: 243273:MG_RS01400
uniprot id: P47481
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

243273:MG RS02385
gene id: 243273:MG_RS02385
uniprot id: P47632
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Probably essential, it was not disrupted in a global transposon mutagenesis study.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

243273:MG RS00195
gene id: 243273:MG_RS00195
uniprot id: P47285
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the oxidation of glycerol 3-phosphate to dihydroxyacetone phosphate (DHAP), with a reduction of O2 to H2O2. The formation of hydrogen peroxide by this enzyme is crucial for cytotoxic effects on host cells. Does not show any dehydrogenase activity with NAD(+).
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

243273:MG RS00405
gene id: 243273:MG_RS00405
uniprot id: P47317
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type II subfamily.
messages: Cell membrane
messages: Could mediate calcium influx.

243273:MG RS01155
gene id: 243273:MG_RS01155
uniprot id: P47446
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.
messages: Cell membrane
messages: Heterotetramer composed of ParC and ParE.
messages: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

243273:MG RS01320
gene id: 243273:MG_RS01320
uniprot id: P47466
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

243273:MG RS00960
gene id: 243273:MG_RS00960
uniprot id: P47416
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

243273:MG RS01555
gene id: 243273:MG_RS01555
uniprot id: Q49406
names: Function
messages: 5'-3' exonuclease acting preferentially on double-stranded DNA.

243273:MG RS00940
gene id: 243273:MG_RS00940
uniprot id: P47412
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

243273:MG RS00515
gene id: 243273:MG_RS00515
uniprot id: P47339
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

243273:MG RS02490
gene id: 243273:MG_RS02490
uniprot id: P47652
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS00895
gene id: 243273:MG_RS00895
uniprot id: P47403
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

243273:MG RS00250
gene id: 243273:MG_RS00250
uniprot id: P47295
names: Disruption Phenotype
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
messages: Homohexamer; trimer of homodimers.
messages: Probably essential, it was not disrupted in a global transposon mutagenesis study.

243273:MG RS02395
gene id: 243273:MG_RS02395
uniprot id: P47634
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

243273:MG RS02645
gene id: 243273:MG_RS02645
uniprot id: P47686
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.

243273:MG RS00920
gene id: 243273:MG_RS00920
uniprot id: P47408
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

243273:MG RS02670
gene id: 243273:MG_RS02670
uniprot id: P47691
names: Function
names: Similarity
messages: Belongs to the UDPGP type 2 family.
messages: May play a role in stationary phase survival.

243273:MG RS02420
gene id: 243273:MG_RS02420
uniprot id: P47638
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

243273:MG RS01125
gene id: 243273:MG_RS01125
uniprot id: P47441
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family. RnhC subfamily.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.
messages: Probably essential, it was not disrupted in a global transposon mutagenesis study.

243273:MG RS00905
gene id: 243273:MG_RS00905
uniprot id: P47405
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

243273:MG RS00685
gene id: 243273:MG_RS00685
uniprot id: P47372
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

243273:MG RS00725
gene id: 243273:MG_RS00725
uniprot id: P47379
names: Disruption Phenotype
names: Subcellular Location Annotation
messages: Cell membrane
messages: Probably essential, it was not disrupted in a global transposon mutagenesis study.

243273:MG RS00505
gene id: 243273:MG_RS00505
uniprot id: P47337
names: Subunit
messages: Homotetramer.

243273:MG RS02380
gene id: 243273:MG_RS02380
uniprot id: P47631
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity).

243273:MG RS01420
gene id: 243273:MG_RS01420
uniprot id: P47485
names: Subcellular Location Annotation
messages: Cell membrane

243273:MG RS02350
gene id: 243273:MG_RS02350
uniprot id: P47625
names: Similarity
messages: To M.genitalium MG293.
messages: To glycerophosphoryl diester phosphodiesterases (EC 3.1.4.46).

243273:MG RS01885
gene id: 243273:MG_RS01885
uniprot id: P47558
names: Similarity
names: Subcellular Location Annotation
messages: Cell membrane
messages: To B.subtilis ComEC.