243230:E5E91 RS00915
gene id: 243230:E5E91_RS00915
uniprot id: Q9RXX6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

243230:E5E91 RS07545
gene id: 243230:E5E91_RS07545
uniprot id: Q9RU95
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 23 kDa subunit family.
messages: Binds 2 [4Fe-4S] clusters per subunit.
messages: Cell membrane
messages: NDH-1 is composed of 15 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

243230:E5E91 RS04490
gene id: 243230:E5E91_RS04490
uniprot id: Q9RVZ0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

243230:E5E91 RS12240
gene id: 243230:E5E91_RS12240
uniprot id: Q9RRR3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M32 family.
messages: Binds 1 zinc ion per subunit.
messages: Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.

243230:E5E91 RS08815
gene id: 243230:E5E91_RS08815
uniprot id: Q9RTK8
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS04295
gene id: 243230:E5E91_RS04295
uniprot id: Q9RW28
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metal hydrolase YfiT family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Possible metal-dependent hydrolase.

243230:E5E91 RS13630
gene id: 243230:E5E91_RS13630
uniprot id: Q9RZ93
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS10890
gene id: 243230:E5E91_RS10890
uniprot id: Q9RSG0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

243230:E5E91 RS10650
gene id: 243230:E5E91_RS10650
uniprot id: Q9RSK9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Contacts proteins L4, L21 and L35.

243230:E5E91 RS04615
gene id: 243230:E5E91_RS04615
uniprot id: Q9RVW5
names: Similarity
messages: Belongs to the type II topoisomerase GyrB family.

243230:E5E91 RS08765
gene id: 243230:E5E91_RS08765
uniprot id: Q9RTL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI family.
messages: Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
messages: Cytoplasm

243230:E5E91 RS12885
gene id: 243230:E5E91_RS12885
uniprot id: Q9RRE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglycosylase MltG family.
messages: Cell membrane
messages: Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.

243230:E5E91 RS09165
gene id: 243230:E5E91_RS09165
uniprot id: Q9RTE6
names: Function
names: Similarity
messages: Belongs to the uve1/UvsE family.
messages: Component in a DNA repair pathway. Removal of UV LIGHT damaged nucleotides. Recognizes pyrimidine dimers and cleave a phosphodiester bond immediately 5' to the lesion.

243230:E5E91 RS00665
gene id: 243230:E5E91_RS00665
uniprot id: Q9RY22
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

243230:E5E91 RS09250
gene id: 243230:E5E91_RS09250
uniprot id: Q9RTC9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

243230:E5E91 RS11245
gene id: 243230:E5E91_RS11245
uniprot id: Q9RSA0
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

243230:E5E91 RS08940
gene id: 243230:E5E91_RS08940
uniprot id: Q9RTI9
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

243230:E5E91 RS08480
gene id: 243230:E5E91_RS08480
uniprot id: Q9RTR9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.

243230:E5E91 RS12320
gene id: 243230:E5E91_RS12320
uniprot id: Q9RRQ0
names: Similarity
messages: Belongs to the Nth/MutY family.

243230:E5E91 RS10635
gene id: 243230:E5E91_RS10635
uniprot id: Q9RSL2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 23S rRNA (By similarity). Contacts protein L27 and the 5S rRNA.
messages: This is one of the proteins that binds and mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

243230:E5E91 RS07125
gene id: 243230:E5E91_RS07125
uniprot id: Q9RUH5
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS11595
gene id: 243230:E5E91_RS11595
uniprot id: Q9RS33
names: Similarity
messages: Belongs to the CutA family.

243230:E5E91 RS01670
gene id: 243230:E5E91_RS01670
uniprot id: Q9RXI4
names: Similarity
messages: Belongs to the Nudix hydrolase family.

243230:E5E91 RS13530
gene id: 243230:E5E91_RS13530
uniprot id: Q9RZB3
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

243230:E5E91 RS12670
gene id: 243230:E5E91_RS12670
uniprot id: P56867
names: Function
names: Miscellaneous
names: PTM
names: Subcellular Location Annotation
messages: Glycosylated. Contains tightly bound reducing sugars (six per polypeptide chain) and fatty acids (covalently bound and located in the N-terminal region) (By similarity).
messages: S-layer
messages: Shape maintenance, possible protection from noxious enzymes or exogenous and unsettling DNA, and may mediate homotypic cell-cell contacts.
messages: The hydrophilic C-terminal region rich in aromatic AA could be engaged in interactions with nucleic acids, and the bound fatty acids and the N-terminal region could serve to anchor the layer to the outer membrane of D.radiodurans. HPI layer contain about 30% beta structure and virtually no alpha helix (By similarity).

243230:E5E91 RS02130
gene id: 243230:E5E91_RS02130
uniprot id: Q9RX93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. Tam family.
messages: Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.
messages: Cytoplasm

243230:E5E91 RS01585
gene id: 243230:E5E91_RS01585
uniprot id: Q9RXK1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly (By similarity).
messages: Part of the 50S ribosomal subunit. Contacts proteins L15 and L34.
messages: This protein is located close to the polypeptide exit tunnel, and interacts with the modified macrolide azithromycin, which blocks the tunnel.

243230:E5E91 RS01630
gene id: 243230:E5E91_RS01630
uniprot id: Q9RXJ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Forms part of two intersubunit bridges in the 70S ribosome (By similarity). Binds to 23S rRNA.
messages: In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8 (By similarity). Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19.

243230:E5E91 RS13320
gene id: 243230:E5E91_RS13320
uniprot id: Q9RR60
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

243230:E5E91 RS04060
gene id: 243230:E5E91_RS04060
uniprot id: Q9RW75
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the transfer of the amino group of L-glutamate to [LysW]-aminoadipate 6-semialdehyde, generating [LysW]-gamma-L-lysine.
messages: Cytoplasm
messages: Homodimer.

243230:E5E91 RS12460
gene id: 243230:E5E91_RS12460
uniprot id: Q9RRM2
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

243230:E5E91 RS01375
gene id: 243230:E5E91_RS01375
uniprot id: Q9RXP0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity).

243230:E5E91 RS04905
gene id: 243230:E5E91_RS04905
uniprot id: Q9RVQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
messages: Catalyzes the NADPH-dependent reduction of [LysW]-aminoadipate 6-phosphate to yield [LysW]-aminoadipate 6-semialdehyde.
messages: Cytoplasm

243230:E5E91 RS09980
gene id: 243230:E5E91_RS09980
uniprot id: Q9RSY3
names: Function
messages: May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.

243230:E5E91 RS13000
gene id: 243230:E5E91_RS13000
uniprot id: Q9RRB7
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPase class C family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: On the 2D-gel the determined pI of this protein is: 4.65, its MW is: 32 kDa.

243230:E5E91 RS05185
gene id: 243230:E5E91_RS05185
uniprot id: Q9RVK8
names: Similarity
messages: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

243230:E5E91 RS14200
gene id: 243230:E5E91_RS14200
uniprot id: Q9RYY1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThiG family.
messages: Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
messages: Cytoplasm
messages: Homotetramer. Forms heterodimers with either ThiH or ThiS.

243230:E5E91 RS09045
gene id: 243230:E5E91_RS09045
uniprot id: Q9RTG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

243230:E5E91 RS01100
gene id: 243230:E5E91_RS01100
uniprot id: Q9RXU0
names: Similarity
messages: Belongs to the SufE family.

243230:E5E91 RS06400
gene id: 243230:E5E91_RS06400
uniprot id: Q9RUW8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Ro 60 kDa family.
messages: Binds to several small RNAs that accumulate during recovery from UV irradiation (PubMed:17392270). Contributes to the resistance of D.radiodurans to ultraviolet irradiation (PubMed:10766734).
messages: Cytoplasm
messages: Forms oligomers upon binding DrY RNA, The multimers are of an average size of 700 kDa and are composed of around 12 molecules of Rsr-DrY RNA.
messages: The MIDAS-like motif in the VWFA-like domain binds divalent metal cations.
messages: The horseshoe-shaped TROVE domain is built with 7 helical HEAT-like repeats, and is closed by the VWFA-like domain giving rise to a ring-shaped monomer. Single-stranded RNA is bound in the positively charged central cavity.

243230:E5E91 RS00500
gene id: 243230:E5E91_RS00500
uniprot id: Q9RY54
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS12395
gene id: 243230:E5E91_RS12395
uniprot id: Q9RRN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

243230:E5E91 RS12365
gene id: 243230:E5E91_RS12365
uniprot id: Q9RRP1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

243230:E5E91 RS02140
gene id: 243230:E5E91_RS02140
uniprot id: Q9RX92
names: Disruption Phenotype
names: Function
names: Induction
names: Similarity
names: Subunit
messages: Belongs to the RAD52 family.
messages: Cells lacking this gene show a normal growth rate, do not exhibit a decrease in the efficiency of natural transformation, but display a reduced capacity to survive ionizing radiation when exposed at doses superior to 2.5 kGy and exhibit increased sensitivity to mitomycin C.
messages: Homooligomer composed of 8 to 10 subunits; probably arranged in a ring-structure.
messages: Induced to high levels following extreme ionizing radiation exposure. Also highly induced in response to desiccation stress.
messages: ssDNA-binding protein that contributes to the ionizing radiation resistance of D.radiodurans. Plays a role in DNA repair and genome reconstitution, in a RecA-independent process, since DdrA is essential for recovery from severe genomic fragmentation as a result of exposure to severe levels of ionizing radiation in an environment lacking nutrients. In vitro, binds to the 3'-ends of single-stranded DNA, protecting them from nuclease degradation. Thus, DdrA is part of a DNA end-protection system that helps to preserve genome integrity following irradiation or desiccation. Does not display DNA strand annealing activity, unlike eukaryotic Rad52 protein homologs.

243230:E5E91 RS02555
gene id: 243230:E5E91_RS02555
uniprot id: Q9RX14
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
messages: Cell membrane
messages: Monomer.

243230:E5E91 RS04095
gene id: 243230:E5E91_RS04095
uniprot id: Q9RW68
names: Similarity
messages: Belongs to the lycopene cyclase family.

243230:E5E91 RS01515
gene id: 243230:E5E91_RS01515
uniprot id: Q9RXL3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.
messages: Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
messages: Cytoplasm

243230:E5E91 RS02880
gene id: 243230:E5E91_RS02880
uniprot id: Q9RWV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243230:E5E91 RS01775
gene id: 243230:E5E91_RS01775
uniprot id: Q9RXG4
names: Function
names: Induction
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
messages: Belongs to the peptidase S16 family.
messages: By heat shock.
messages: Cytoplasm
messages: Homohexamer. Organized in a ring with a central cavity.

243230:E5E91 RS12475
gene id: 243230:E5E91_RS12475
uniprot id: Q9RRL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity).

243230:E5E91 RS06125
gene id: 243230:E5E91_RS06125
uniprot id: Q9RV24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Maf family. YhdE subfamily.
messages: Cytoplasm
messages: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.

243230:E5E91 RS11935
gene id: 243230:E5E91_RS11935
uniprot id: P50933
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by fructose 1,6-bisphosphate (FBP).
messages: Belongs to the LDH/MDH superfamily. LDH family.
messages: Catalyzes the conversion of lactate to pyruvate.
messages: Cytoplasm
messages: Homotetramer.

243230:E5E91 RS14135
gene id: 243230:E5E91_RS14135
uniprot id: Q9RYZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane

243230:E5E91 RS05430
gene id: 243230:E5E91_RS05430
uniprot id: Q9RVG1
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

243230:E5E91 RS00010
gene id: 243230:E5E91_RS00010
uniprot id: Q9RYE7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).

243230:E5E91 RS07055
gene id: 243230:E5E91_RS07055
uniprot id: Q9RUJ1
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

243230:E5E91 RS00260
gene id: 243230:E5E91_RS00260
uniprot id: Q9RYA1
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily.
messages: Specifically methylates the cytosine at position 2499 (m5C2499) of 23S rRNA.

243230:E5E91 RS08920
gene id: 243230:E5E91_RS08920
uniprot id: Q46577
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. UvrA family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrB during the search for lesions.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

243230:E5E91 RS06915
gene id: 243230:E5E91_RS06915
uniprot id: Q9RUL9
names: Similarity
messages: Belongs to the aspartokinase family.

243230:E5E91 RS11945
gene id: 243230:E5E91_RS11945
uniprot id: P49228
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL32 family.
messages: Binds 1 zinc ion per subunit.
messages: Forms a cluster with L17 and L22, and with L22, a pair of 'tweezers' that hold together all the domains of the 23S rRNA. Interacts with the antibiotic troleandomycin which blocks the peptide exit tunnel.
messages: Part of the 50S ribosomal subunit. Contacts proteins L17 and L22.

243230:E5E91 RS02785
gene id: 243230:E5E91_RS02785
uniprot id: Q9RWW9
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Periplasm

243230:E5E91 RS11810
gene id: 243230:E5E91_RS11810
uniprot id: P42443
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity). Probably involved in base excision repair (PubMed:19303848).
messages: Cytoplasm
messages: Following severe irradiation (7 kGy of gamma irradiation) genomic DNA is fragmented. DNA is progressively degraded for the first 1.5 hours after IR, in a step promoted by RecA and counterbalanced by DNA Pol I and Pol III, followed by massive DNA synthesis and genome reassembly in the next hour. Optimal priming of DNA synthesis requires both RecA and RadA, Pol III initiates DNA synthesis while both Pol I and Pol III are required for its contination. In the absence of RecA the majority of the chromosome is still reconstituted, via either single-strand annealing or non-homologous end joining (PubMed:19303848).
messages: Reduced DNA synthesis rate even in the absence of ionizing radiation (IR) (PubMed:19303848). Cells lacking this gene have a reduced capacity to survive IR (from 90% survival to <10(-7)), DNA repair following IR is slow (PubMed:20451472, PubMed:19303848). Single recA mutants rarely reconstitutes the whole genome following IR, and their DNA is not degraded post-IR (PubMed:19303848). A double recA-ddrB disruption shows no signs of DNA repair 24 hours after IR (PubMed:20451472). Double recA-radA deletion mutants have a more severe effect than either mutation alone after IR (PubMed:19303848).

243230:E5E91 RS02955
gene id: 243230:E5E91_RS02955
uniprot id: Q9RWU0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

243230:E5E91 RS14340
gene id: 243230:E5E91_RS14340
uniprot id: Q9RYV5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

243230:E5E91 RS15750
gene id: 243230:E5E91_RS15750
uniprot id: Q9RZJ9
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS11880
gene id: 243230:E5E91_RS11880
uniprot id: Q9RRX9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the asparaginase 1 family.
messages: Cytoplasm

243230:E5E91 RS14375
gene id: 243230:E5E91_RS14375
uniprot id: Q9RYU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

243230:E5E91 RS03225
gene id: 243230:E5E91_RS03225
uniprot id: Q9RWP0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).

243230:E5E91 RS06335
gene id: 243230:E5E91_RS06335
uniprot id: Q9RUY2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

243230:E5E91 RS02155
gene id: 243230:E5E91_RS02155
uniprot id: Q9RX89
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity).

243230:E5E91 RS02895
gene id: 243230:E5E91_RS02895
uniprot id: Q9RWU9
names: Subcellular Location Annotation
messages: Nucleus

243230:E5E91 RS02480
gene id: 243230:E5E91_RS02480
uniprot id: Q9RX28
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS05215
gene id: 243230:E5E91_RS05215
uniprot id: Q9RVK2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Homodimer.
messages: Hydrolase that can act as a nucleoside triphosphatase and a dinucleoside polyphosphate pyrophosphatase. The best substrates are 8-oxo-dGTP and 8-oxo-GTP. Other substrates include Ap4A, dGTP and GTP. May be involved in protection from damage caused by radiation.

243230:E5E91 RS05210
gene id: 243230:E5E91_RS05210
uniprot id: Q9RVK3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metal hydrolase YfiT family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Possible metal-dependent hydrolase.

243230:E5E91 RS00760
gene id: 243230:E5E91_RS00760
uniprot id: Q9RY06
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

243230:E5E91 RS04735
gene id: 243230:E5E91_RS04735
uniprot id: Q9RVU3
names: Similarity
messages: Belongs to the acylphosphatase family.

243230:E5E91 RS04430
gene id: 243230:E5E91_RS04430
uniprot id: Q9RW02
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

243230:E5E91 RS04115
gene id: 243230:E5E91_RS04115
uniprot id: Q9RW63
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

243230:E5E91 RS12840
gene id: 243230:E5E91_RS12840
uniprot id: Q9RRE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 1 subfamily.
messages: Cytoplasm

243230:E5E91 RS10020
gene id: 243230:E5E91_RS10020
uniprot id: Q9RSX5
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS10655
gene id: 243230:E5E91_RS10655
uniprot id: Q9RSK8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

243230:E5E91 RS06510
gene id: 243230:E5E91_RS06510
uniprot id: Q9RUV0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the YmdB-like family.
messages: Has a dual activity phosphatase/phosphodiesterase in vitro, with a preference to phosphoenolpyruvate (PEP) and 2',3'-cAMP, respectively. Can also use 2',3'-cGMP, 2',3'-cCMP and various model substrates such as p-nitrophenyl phosphate (pNPP), bis-p-nitrophenyl phosphate (bis-pNPP) and p-nitrophenyl thymidine monophosphate (pNP-TMP).
messages: Mn(2+) is the preferable metal for phosphatase activity. Phosphodiesterase activity is observed in the presence of Co(2+), Mn(2+) or Fe(2+).

243230:E5E91 RS00455
gene id: 243230:E5E91_RS00455
uniprot id: Q9RY63
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

243230:E5E91 RS06500
gene id: 243230:E5E91_RS06500
uniprot id: Q9RUV2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homodimer.

243230:E5E91 RS04880
gene id: 243230:E5E91_RS04880
uniprot id: Q9RVR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

243230:E5E91 RS07665
gene id: 243230:E5E91_RS07665
uniprot id: Q9RU72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

243230:E5E91 RS08050
gene id: 243230:E5E91_RS08050
uniprot id: Q9RTZ6
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS06725
gene id: 243230:E5E91_RS06725
uniprot id: Q9RUQ8
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS06430
gene id: 243230:E5E91_RS06430
uniprot id: Q9RUW4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). Can inadvertently accommodate and process cysteine.
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

243230:E5E91 RS04315
gene id: 243230:E5E91_RS04315
uniprot id: Q9RW24
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

243230:E5E91 RS00985
gene id: 243230:E5E91_RS00985
uniprot id: Q9RXW2
names: Similarity
messages: Belongs to the FUN14 family.

243230:E5E91 RS12810
gene id: 243230:E5E91_RS12810
uniprot id: Q9RRF5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MsrQ family.
messages: Binds 1 FMN per subunit.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Cell membrane
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.

243230:E5E91 RS01575
gene id: 243230:E5E91_RS01575
uniprot id: Q9RXK3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

243230:E5E91 RS10945
gene id: 243230:E5E91_RS10945
uniprot id: Q9RSF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

243230:E5E91 RS09140
gene id: 243230:E5E91_RS09140
uniprot id: Q9RTF0
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

243230:E5E91 RS13045
gene id: 243230:E5E91_RS13045
uniprot id: Q9RRB1
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

243230:E5E91 RS09985
gene id: 243230:E5E91_RS09985
uniprot id: Q9RSY2
names: Miscellaneous
messages: On the 2D-gel the determined pI of this unknown protein is: 4.23, its MW is: 31.5 kDa.

243230:E5E91 RS02265
gene id: 243230:E5E91_RS02265
uniprot id: Q9RX68
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

243230:E5E91 RS03185
gene id: 243230:E5E91_RS03185
uniprot id: Q9RWP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

243230:E5E91 RS11830
gene id: 243230:E5E91_RS11830
uniprot id: Q9RRY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

243230:E5E91 RS03350
gene id: 243230:E5E91_RS03350
uniprot id: Q9RWL5
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

243230:E5E91 RS09760
gene id: 243230:E5E91_RS09760
uniprot id: Q9RT26
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

243230:E5E91 RS01590
gene id: 243230:E5E91_RS01590
uniprot id: Q9RXK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly protein (By similarity) it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. Forms the main docking site for trigger factor binding to the ribosome (PubMed:16091460, PubMed:16271892).
messages: Part of the 50S ribosomal subunit. Contacts protein L29 and trigger factor when it is bound to the ribosome (PubMed:16091460, PubMed:16271892).

243230:E5E91 RS10620
gene id: 243230:E5E91_RS10620
uniprot id: Q9RSL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

243230:E5E91 RS03545
gene id: 243230:E5E91_RS03545
uniprot id: Q9RWH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

243230:E5E91 RS00445
gene id: 243230:E5E91_RS00445
uniprot id: Q9RY65
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL27 family.
messages: Binds the 5S and 23S rRNAs and also the tRNA in the P site.
messages: Part of the 50S ribosomal subunit. Contacts protein L18.

243230:E5E91 RS01345
gene id: 243230:E5E91_RS01345
uniprot id: Q9RXP5
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

243230:E5E91 RS10505
gene id: 243230:E5E91_RS10505
uniprot id: Q9RSN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

243230:E5E91 RS07010
gene id: 243230:E5E91_RS07010
uniprot id: Q9RUK0
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

243230:E5E91 RS04645
gene id: 243230:E5E91_RS04645
uniprot id: Q9RVW0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

243230:E5E91 RS14535
gene id: 243230:E5E91_RS14535
uniprot id: Q9RYR8
names: Function
names: Similarity
messages: Belongs to the CobT family.
messages: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).

243230:E5E91 RS02830
gene id: 243230:E5E91_RS02830
uniprot id: Q9RWW0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

243230:E5E91 RS10875
gene id: 243230:E5E91_RS10875
uniprot id: Q9RSG3
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

243230:E5E91 RS07235
gene id: 243230:E5E91_RS07235
uniprot id: Q9RUF3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

243230:E5E91 RS03965
gene id: 243230:E5E91_RS03965
uniprot id: Q9RW94
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

243230:E5E91 RS07690
gene id: 243230:E5E91_RS07690
uniprot id: Q9RU68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

243230:E5E91 RS09060
gene id: 243230:E5E91_RS09060
uniprot id: Q9RTG5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

243230:E5E91 RS10070
gene id: 243230:E5E91_RS10070
uniprot id: Q9RSW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S rRNA, probably serving to organize its structure.
messages: Part of the 50S ribosomal subunit. Contacts proteins L13 and L21.

243230:E5E91 RS01065
gene id: 243230:E5E91_RS01065
uniprot id: Q9RXU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmG family. TrmFO subfamily.
messages: Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
messages: Cytoplasm

243230:E5E91 RS07585
gene id: 243230:E5E91_RS07585
uniprot id: Q9RU87
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 15 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

243230:E5E91 RS00330
gene id: 243230:E5E91_RS00330
uniprot id: Q9RY86
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnC family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).

243230:E5E91 RS07390
gene id: 243230:E5E91_RS07390
uniprot id: Q9RUC2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

243230:E5E91 RS05505
gene id: 243230:E5E91_RS05505
uniprot id: Q9RVE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.
messages: Cytoplasm
messages: Interacts with 100S ribosomes.
messages: Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.

243230:E5E91 RS00060
gene id: 243230:E5E91_RS00060
uniprot id: Q9RYD8
names: Function
names: Similarity
messages: Belongs to the ParB family.
messages: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication (By similarity).

243230:E5E91 RS00895
gene id: 243230:E5E91_RS00895
uniprot id: Q9RXY0
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

243230:E5E91 RS06935
gene id: 243230:E5E91_RS06935
uniprot id: Q9RUL5
names: Subcellular Location Annotation
messages: Cytoplasm

243230:E5E91 RS02800
gene id: 243230:E5E91_RS02800
uniprot id: Q9RWW6
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

243230:E5E91 RS13690
gene id: 243230:E5E91_RS13690
uniprot id: Q9RZ81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

243230:E5E91 RS12605
gene id: 243230:E5E91_RS12605
uniprot id: Q9RRJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

243230:E5E91 RS06170
gene id: 243230:E5E91_RS06170
uniprot id: Q9RV15
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

243230:E5E91 RS00125
gene id: 243230:E5E91_RS00125
uniprot id: Q9RYC7
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

243230:E5E91 RS14255
gene id: 243230:E5E91_RS14255
uniprot id: Q9RYX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Cell membrane
messages: Membrane

243230:E5E91 RS11405
gene id: 243230:E5E91_RS11405
uniprot id: Q9RS71
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

243230:E5E91 RS09310
gene id: 243230:E5E91_RS09310
uniprot id: Q9RTB7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
messages: Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
messages: Monomer.

243230:E5E91 RS12530
gene id: 243230:E5E91_RS12530
uniprot id: Q9RRK9
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

243230:E5E91 RS00565
gene id: 243230:E5E91_RS00565
uniprot id: Q9RY41
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
messages: Homohexamer.

243230:E5E91 RS07610
gene id: 243230:E5E91_RS07610
uniprot id: Q9RU82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

243230:E5E91 RS05145
gene id: 243230:E5E91_RS05145
uniprot id: Q9RVL6
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

243230:E5E91 RS13055
gene id: 243230:E5E91_RS13055
uniprot id: Q9RRA9
names: Similarity
messages: Belongs to the flavoredoxin family.

243230:E5E91 RS01500
gene id: 243230:E5E91_RS01500
uniprot id: Q9RXL6
names: Similarity
messages: Belongs to the NAPRTase family.

243230:E5E91 RS05910
gene id: 243230:E5E91_RS05910
uniprot id: Q9RV68
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

243230:E5E91 RS07315
gene id: 243230:E5E91_RS07315
uniprot id: Q9RUD7
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS00510
gene id: 243230:E5E91_RS00510
uniprot id: Q9RY52
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

243230:E5E91 RS05135
gene id: 243230:E5E91_RS05135
uniprot id: Q9RVL9
names: Similarity
messages: Belongs to the ribF family.

243230:E5E91 RS01130
gene id: 243230:E5E91_RS01130
uniprot id: Q9RXT4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

243230:E5E91 RS07685
gene id: 243230:E5E91_RS07685
uniprot id: Q9RU69
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

243230:E5E91 RS07565
gene id: 243230:E5E91_RS07565
uniprot id: Q9RU91
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

243230:E5E91 RS00610
gene id: 243230:E5E91_RS00610
uniprot id: Q9RY31
names: Similarity
messages: Belongs to the DprA/Smf family.

243230:E5E91 RS11840
gene id: 243230:E5E91_RS11840
uniprot id: Q9RRY7
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily.
messages: Binds 2 divalent metal cations.
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

243230:E5E91 RS03980
gene id: 243230:E5E91_RS03980
uniprot id: Q9RW91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

243230:E5E91 RS03480
gene id: 243230:E5E91_RS03480
uniprot id: Q9RWJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

243230:E5E91 RS04420
gene id: 243230:E5E91_RS04420
uniprot id: Q9RW04
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.

243230:E5E91 RS01195
gene id: 243230:E5E91_RS01195
uniprot id: Q9RXS0
names: Similarity
messages: Belongs to the peptidase M29 family.

243230:E5E91 RS10770
gene id: 243230:E5E91_RS10770
uniprot id: Q9RSI4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

243230:E5E91 RS05315
gene id: 243230:E5E91_RS05315
uniprot id: Q9RVI3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ClpA/ClpB family.
messages: Cytoplasm
messages: Homohexamer. The oligomerization is ATP-dependent (By similarity).
messages: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity).
messages: The Clp repeat (R) domain probably functions as a substrate-discriminating domain, recruiting aggregated proteins to the ClpB hexamer and/or stabilizing bound proteins. The NBD2 domain is responsible for oligomerization, whereas the NBD1 domain stabilizes the hexamer probably in an ATP-dependent manner. The movement of the coiled-coil domain is essential for ClpB ability to rescue proteins from an aggregated state, probably by pulling apart large aggregated proteins, which are bound between the coiled-coils motifs of adjacent ClpB subunits in the functional hexamer (By similarity).

243230:E5E91 RS03165
gene id: 243230:E5E91_RS03165
uniprot id: Q9RWQ1
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

243230:E5E91 RS01640
gene id: 243230:E5E91_RS01640
uniprot id: Q9RXJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Forms a bridge to the 30S subunit in the 70S ribosome (By similarity). Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 (CTC) subcomplex. Is known to contact the 5S rRNA, 23S rRNA and the P site tRNA.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement (By similarity). Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

243230:E5E91 RS03000
gene id: 243230:E5E91_RS03000
uniprot id: Q9RWT1
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

243230:E5E91 RS05450
gene id: 243230:E5E91_RS05450
uniprot id: Q9RVF7
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

243230:E5E91 RS06085
gene id: 243230:E5E91_RS06085
uniprot id: Q9RV32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

243230:E5E91 RS00170
gene id: 243230:E5E91_RS00170
uniprot id: Q9RYB8
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

243230:E5E91 RS03975
gene id: 243230:E5E91_RS03975
uniprot id: Q9RW92
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
messages: Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).
messages: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243230:E5E91 RS03865
gene id: 243230:E5E91_RS03865
uniprot id: Q9RWB4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity). Binds the 23S rRNA.

243230:E5E91 RS09875
gene id: 243230:E5E91_RS09875
uniprot id: Q9RT03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.
messages: Homodimer.
messages: Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine and hypoxanthine. Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate. Also has adenosine deaminase activity.

243230:E5E91 RS03275
gene id: 243230:E5E91_RS03275
uniprot id: Q9RWN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

243230:E5E91 RS01135
gene id: 243230:E5E91_RS01135
uniprot id: Q9RXT3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

243230:E5E91 RS00410
gene id: 243230:E5E91_RS00410
uniprot id: Q9RY71
names: Activity Regulation
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Nudix hydrolase family.
messages: Hydrolase that converts various nucleotide triphosphates (NTPs) to the corresponding nucleotide monophosphates and diphosphate, and nucleotide diphosphates to nucleotide monophosphates and inorganic phosphate. Has a marked preference for cytosine ribonucleoside 5'-diphosphate (CDP) and cytosine ribonucleoside 5'-triphosphate (CTP). Has lower activity towards the deoxyribose nucleotides dCDP and dCTP, and towards dGDP, TDP and UDP.
messages: Inhibited by zinc, calcium or copper ions.
messages: Monomer.

243230:E5E91 RS04450
gene id: 243230:E5E91_RS04450
uniprot id: Q9RVZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. MetX family.
messages: Cytoplasm
messages: Homodimer.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

243230:E5E91 RS01120
gene id: 243230:E5E91_RS01120
uniprot id: Q9RXT6
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

243230:E5E91 RS09200
gene id: 243230:E5E91_RS09200
uniprot id: Q9RTD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyl phosphate reductase family.
messages: Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
messages: Cytoplasm

243230:E5E91 RS14705
gene id: 243230:E5E91_RS14705
uniprot id: Q9RYN3
names: Similarity
messages: Belongs to the malate synthase family.

243230:E5E91 RS10575
gene id: 243230:E5E91_RS10575
uniprot id: Q9RSM3
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

243230:E5E91 RS15540
gene id: 243230:E5E91_RS15540
uniprot id: Q9RZN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpA family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

243230:E5E91 RS03430
gene id: 243230:E5E91_RS03430
uniprot id: Q9RWK0
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

243230:E5E91 RS13370
gene id: 243230:E5E91_RS13370
uniprot id: Q9RZE1
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS13035
gene id: 243230:E5E91_RS13035
uniprot id: Q9RRB3
names: Similarity
messages: Belongs to the LytR/CpsA/Psr (LCP) family.

243230:E5E91 RS10625
gene id: 243230:E5E91_RS10625
uniprot id: Q9RSL4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

243230:E5E91 RS14435
gene id: 243230:E5E91_RS14435
uniprot id: Q9RYT8
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

243230:E5E91 RS08690
gene id: 243230:E5E91_RS08690
uniprot id: O83026
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.
messages: The N-terminal domain contains the ATP/Pi binding site, the central domain the pyrophosphate/phosphate carrier histidine, and the C-terminal domain the pyruvate binding site.
messages: The reaction takes place in three steps, mediated by a phosphocarrier histidine residue located on the surface of the central domain. The two first partial reactions are catalyzed at an active site located on the N-terminal domain, and the third partial reaction is catalyzed at an active site located on the C-terminal domain. For catalytic turnover, the central domain swivels from the concave surface of the N-terminal domain to that of the C-terminal domain (By similarity).

243230:E5E91 RS08850
gene id: 243230:E5E91_RS08850
uniprot id: Q9RTK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

243230:E5E91 RS05575
gene id: 243230:E5E91_RS05575
uniprot id: Q9RVD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Monomer.

243230:E5E91 RS01710
gene id: 243230:E5E91_RS01710
uniprot id: Q9RXH6
names: Similarity
messages: Belongs to the glycosyl hydrolase 26 family.

243230:E5E91 RS14095
gene id: 243230:E5E91_RS14095
uniprot id: Q9RZ02
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the urocanase family.
messages: Binds 1 NAD(+) per subunit.
messages: Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
messages: Cytoplasm

243230:E5E91 RS08380
gene id: 243230:E5E91_RS08380
uniprot id: Q9RTT9
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS01650
gene id: 243230:E5E91_RS01650
uniprot id: Q9RXI8
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

243230:E5E91 RS06090
gene id: 243230:E5E91_RS06090
uniprot id: Q9RV31
names: Similarity
messages: Belongs to the peptidase C56 family.

243230:E5E91 RS05935
gene id: 243230:E5E91_RS05935
uniprot id: Q9RV63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

243230:E5E91 RS06330
gene id: 243230:E5E91_RS06330
uniprot id: Q9RUY3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

243230:E5E91 RS06645
gene id: 243230:E5E91_RS06645
uniprot id: Q9RUS3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

243230:E5E91 RS03875
gene id: 243230:E5E91_RS03875
uniprot id: Q9RWB2
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the citrate synthase family.
messages: Citrate synthase is found in nearly all cells capable of oxidative metabolism.
messages: Homodimer.
messages: Might regulate the synthesis and function of enzymes involved in later enzymatic steps of Krebs cycle. Loss in activity results in sporulation defect (By similarity).

243230:E5E91 RS06730
gene id: 243230:E5E91_RS06730
uniprot id: Q9RUQ7
names: Similarity
messages: Belongs to the peptidase C40 family.

243230:E5E91 RS03550
gene id: 243230:E5E91_RS03550
uniprot id: Q9RWH8
names: Similarity
messages: Belongs to the type IB topoisomerase family.

243230:E5E91 RS12470
gene id: 243230:E5E91_RS12470
uniprot id: Q9RRM0
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS05900
gene id: 243230:E5E91_RS05900
uniprot id: Q9RV70
names: Function
names: Similarity
messages: Belongs to the uricase family.
messages: Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.

243230:E5E91 RS01610
gene id: 243230:E5E91_RS01610
uniprot id: Q9RXJ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

243230:E5E91 RS14405
gene id: 243230:E5E91_RS14405
uniprot id: Q9RYU4
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the WrbA family.
messages: Binds 1 FMN per monomer.
messages: Homotetramer.

243230:E5E91 RS13660
gene id: 243230:E5E91_RS13660
uniprot id: Q9RZ87
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit B family.

243230:E5E91 RS13595
gene id: 243230:E5E91_RS13595
uniprot id: Q9RZ99
names: Activity Regulation
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.
messages: Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.
messages: Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.

243230:E5E91 RS04820
gene id: 243230:E5E91_RS04820
uniprot id: Q9RVS6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

243230:E5E91 RS14155
gene id: 243230:E5E91_RS14155
uniprot id: Q9RYZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Cell inner membrane
messages: Membrane

243230:E5E91 RS00405
gene id: 243230:E5E91_RS00405
uniprot id: Q9RY72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

243230:E5E91 RS09730
gene id: 243230:E5E91_RS09730
uniprot id: Q9RT31
names: Similarity
messages: Belongs to the peptidase S8 family.

243230:E5E91 RS10605
gene id: 243230:E5E91_RS10605
uniprot id: Q9RSL7
names: Similarity
messages: Belongs to the ABC transporter superfamily. Ycf16 family.

243230:E5E91 RS02145
gene id: 243230:E5E91_RS02145
uniprot id: Q9RX91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

243230:E5E91 RS10240
gene id: 243230:E5E91_RS10240
uniprot id: Q9RST8
names: Similarity
messages: Belongs to the UPF0548 family.

243230:E5E91 RS01435
gene id: 243230:E5E91_RS01435
uniprot id: Q9RXM8
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS13410
gene id: 243230:E5E91_RS13410
uniprot id: P56864
names: Similarity
messages: Belongs to the sulfate adenylyltransferase family.

243230:E5E91 RS12600
gene id: 243230:E5E91_RS12600
uniprot id: Q9RRJ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription (By similarity).

243230:E5E91 RS05025
gene id: 243230:E5E91_RS05025
uniprot id: P56925
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSP33 family.
messages: Cytoplasm
messages: Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
messages: Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.

243230:E5E91 RS11085
gene id: 243230:E5E91_RS11085
uniprot id: Q9RSC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243230:E5E91 RS13560
gene id: 243230:E5E91_RS13560
uniprot id: Q9RZA7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

243230:E5E91 RS04850
gene id: 243230:E5E91_RS04850
uniprot id: Q9RVS0
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

243230:E5E91 RS04540
gene id: 243230:E5E91_RS04540
uniprot id: Q9RVY1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.
messages: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
messages: Belongs to the DTD family.
messages: Cytoplasm
messages: Homodimer.

243230:E5E91 RS14890
gene id: 243230:E5E91_RS14890
uniprot id: Q9RYJ1
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS07655
gene id: 243230:E5E91_RS07655
uniprot id: Q9RU74
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.

243230:E5E91 RS11665
gene id: 243230:E5E91_RS11665
uniprot id: Q9RS19
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

243230:E5E91 RS00080
gene id: 243230:E5E91_RS00080
uniprot id: Q9RYD4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 2 residues (Tyr-66 and Arg-69) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Cytoplasm
messages: NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.

243230:E5E91 RS09460
gene id: 243230:E5E91_RS09460
uniprot id: Q9RT85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0073 (Hly-III) family.
messages: Membrane

243230:E5E91 RS09390
gene id: 243230:E5E91_RS09390
uniprot id: Q9RT99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

243230:E5E91 RS10245
gene id: 243230:E5E91_RS10245
uniprot id: Q9RST7
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. TreS subfamily.

243230:E5E91 RS09275
gene id: 243230:E5E91_RS09275
uniprot id: Q9RTC4
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS11165
gene id: 243230:E5E91_RS11165
uniprot id: Q9RSB4
names: Function
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA.

243230:E5E91 RS01580
gene id: 243230:E5E91_RS01580
uniprot id: Q9RXK2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. Also contacts proteins L13 and L17.

243230:E5E91 RS04885
gene id: 243230:E5E91_RS04885
uniprot id: Q9RVR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

243230:E5E91 RS06570
gene id: 243230:E5E91_RS06570
uniprot id: Q9RUT7
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

243230:E5E91 RS02775
gene id: 243230:E5E91_RS02775
uniprot id: Q9RWX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

243230:E5E91 RS03915
gene id: 243230:E5E91_RS03915
uniprot id: Q9RWA4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. Lipoyl synthase family.
messages: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
messages: Cytoplasm

243230:E5E91 RS13340
gene id: 243230:E5E91_RS13340
uniprot id: Q9RZE7
names: Function
names: Similarity
messages: Belongs to the ParB family.
messages: Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication (By similarity).

243230:E5E91 RS05105
gene id: 243230:E5E91_RS05105
uniprot id: Q9RVM5
names: Similarity
messages: Belongs to the truncated hemoglobin family. Group II subfamily.

243230:E5E91 RS14895
gene id: 243230:E5E91_RS14895
uniprot id: Q9RYJ0
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS09550
gene id: 243230:E5E91_RS09550
uniprot id: Q9RT67
names: Similarity
messages: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.

243230:E5E91 RS08525
gene id: 243230:E5E91_RS08525
uniprot id: Q9RTR0
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

243230:E5E91 RS09100
gene id: 243230:E5E91_RS09100
uniprot id: Q9RTF7
names: Similarity
messages: Belongs to the HepT RNase toxin family.

243230:E5E91 RS12565
gene id: 243230:E5E91_RS12565
uniprot id: Q9RRK2
names: PTM
messages: Binds 2 heme c groups covalently per subunit.

243230:E5E91 RS01560
gene id: 243230:E5E91_RS01560
uniprot id: Q9RXK5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

243230:E5E91 RS07415
gene id: 243230:E5E91_RS07415
uniprot id: Q9RUB8
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

243230:E5E91 RS02445
gene id: 243230:E5E91_RS02445
uniprot id: Q9RX35
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TtcA family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is chelated by three Cys residues, the fourth Fe has a free coordination site that may bind a sulfur atom transferred from the persulfide of IscS.
messages: Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
messages: Cytoplasm
messages: Homodimer.
messages: The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster.

243230:E5E91 RS06165
gene id: 243230:E5E91_RS06165
uniprot id: Q9RV16
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

243230:E5E91 RS05915
gene id: 243230:E5E91_RS05915
uniprot id: Q9RV67
names: Similarity
messages: Belongs to the GSP E family.

243230:E5E91 RS12800
gene id: 243230:E5E91_RS12800
uniprot id: Q9RRF7
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily.

243230:E5E91 RS09380
gene id: 243230:E5E91_RS09380
uniprot id: Q9RTA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0382 family.
messages: Membrane

243230:E5E91 RS05760
gene id: 243230:E5E91_RS05760
uniprot id: Q9RV97
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.

243230:E5E91 RS13655
gene id: 243230:E5E91_RS13655
uniprot id: Q9RZ88
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

243230:E5E91 RS04700
gene id: 243230:E5E91_RS04700
uniprot id: Q9RVV0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

243230:E5E91 RS10745
gene id: 243230:E5E91_RS10745
uniprot id: Q9RSI9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

243230:E5E91 RS02585
gene id: 243230:E5E91_RS02585
uniprot id: Q9RX08
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DNA polymerase type-C family. DnaE subfamily.
messages: Cytoplasm
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the PolIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex (By similarity).
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative DNA synthesis in bacteria as well as the bulk of DNA synthesis/repair after ionizing radiation (IR) (PubMed:19303848). The alpha chain is the catalytic subunit (PubMed:19303848). Following severe irradiation (7 kGy of gamma irradiation) genomic DNA is fragmented. DNA is progressively degraded for the first 1.5 hours after IR, in a step promoted by RecA and counterbalanced by DNA Pol I and Pol III, followed by massive DNA synthesis and genome reassembly in the next hour. Optimal priming of DNA synthesis requires both RecA and RadA, Pol III initiates DNA synthesis while both Pol I and Pol III are required for its contination (PubMed:19303848). This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity).
messages: Essential, it cannot be deleted.

243230:E5E91 RS05440
gene id: 243230:E5E91_RS05440
uniprot id: Q9RVF9
names: Similarity
messages: Belongs to the peptidase S51 family.

243230:E5E91 RS05125
gene id: 243230:E5E91_RS05125
uniprot id: Q9RVM1
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

243230:E5E91 RS11870
gene id: 243230:E5E91_RS11870
uniprot id: Q9RRY0
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

243230:E5E91 RS06885
gene id: 243230:E5E91_RS06885
uniprot id: Q9RUM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

243230:E5E91 RS04145
gene id: 243230:E5E91_RS04145
uniprot id: Q9RW57
names: Similarity
messages: Belongs to the peptidase S8 family.

243230:E5E91 RS08005
gene id: 243230:E5E91_RS08005
uniprot id: Q9RU07
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

243230:E5E91 RS06190
gene id: 243230:E5E91_RS06190
uniprot id: Q9RV11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

243230:E5E91 RS08115
gene id: 243230:E5E91_RS08115
uniprot id: Q9RTY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

243230:E5E91 RS03690
gene id: 243230:E5E91_RS03690
uniprot id: Q9RWF1
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

243230:E5E91 RS07365
gene id: 243230:E5E91_RS07365
uniprot id: Q9RUD0
names: Similarity
messages: Belongs to the peptidase S8 family.

243230:E5E91 RS09955
gene id: 243230:E5E91_RS09955
uniprot id: Q9RSY7
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

243230:E5E91 RS12980
gene id: 243230:E5E91_RS12980
uniprot id: Q9RRC1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

243230:E5E91 RS14140
gene id: 243230:E5E91_RS14140
uniprot id: Q9RYZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
messages: Cell membrane
messages: Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).

243230:E5E91 RS08350
gene id: 243230:E5E91_RS08350
uniprot id: Q9RTU4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the zinc-containing alcohol dehydrogenase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
messages: Cytoplasm
messages: Homotetramer.

243230:E5E91 RS14175
gene id: 243230:E5E91_RS14175
uniprot id: Q9RYY6
names: Similarity
messages: Belongs to the UPF0215 family.

243230:E5E91 RS04210
gene id: 243230:E5E91_RS04210
uniprot id: Q9RW44
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds the 23S rRNA and interacts with the tRNA in the E site.
messages: Part of the 50S ribosomal subunit. Contacts protein L9.

243230:E5E91 RS08670
gene id: 243230:E5E91_RS08670
uniprot id: Q9RTN4
names: Similarity
messages: Belongs to the cytochrome P450 family.

243230:E5E91 RS07130
gene id: 243230:E5E91_RS07130
uniprot id: Q9RUH3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family. LysK subfamily.
messages: Binds 2 Zn(2+) or Co(2+) ions per subunit.
messages: Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine.
messages: Cytoplasm

243230:E5E91 RS00800
gene id: 243230:E5E91_RS00800
uniprot id: Q9RXZ8
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

243230:E5E91 RS13965
gene id: 243230:E5E91_RS13965
uniprot id: Q9RZ29
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

243230:E5E91 RS13475
gene id: 243230:E5E91_RS13475
uniprot id: Q9RZC4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

243230:E5E91 RS10415
gene id: 243230:E5E91_RS10415
uniprot id: Q9RSQ6
names: Similarity
messages: Belongs to the asp23 family.

243230:E5E91 RS07200
gene id: 243230:E5E91_RS07200
uniprot id: Q9RUG0
names: Similarity
messages: Belongs to the TrpC family.

243230:E5E91 RS10400
gene id: 243230:E5E91_RS10400
uniprot id: Q9RSQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A24 family.
messages: Membrane

243230:E5E91 RS07425
gene id: 243230:E5E91_RS07425
uniprot id: Q9RUB7
names: Similarity
messages: Belongs to the PspA/IM30 family.

243230:E5E91 RS00660
gene id: 243230:E5E91_RS00660
uniprot id: Q9RY23
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock (By similarity).

243230:E5E91 RS07865
gene id: 243230:E5E91_RS07865
uniprot id: Q9RU33
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS07260
gene id: 243230:E5E91_RS07260
uniprot id: Q9RUE8
names: Function
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Probably part of a binding-protein-dependent transport system.

243230:E5E91 RS15035
gene id: 243230:E5E91_RS15035
uniprot id: Q9RYG9
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

243230:E5E91 RS12610
gene id: 243230:E5E91_RS12610
uniprot id: Q9RRJ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

243230:E5E91 RS08790
gene id: 243230:E5E91_RS08790
uniprot id: Q9RTL3
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

243230:E5E91 RS10430
gene id: 243230:E5E91_RS10430
uniprot id: Q9RSQ3
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

243230:E5E91 RS06890
gene id: 243230:E5E91_RS06890
uniprot id: Q9RUM4
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

243230:E5E91 RS14865
gene id: 243230:E5E91_RS14865
uniprot id: Q9RYJ6
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

243230:E5E91 RS04740
gene id: 243230:E5E91_RS04740
uniprot id: Q9RVU2
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
messages: Binds 2 divalent metal cations per subunit.

243230:E5E91 RS05755
gene id: 243230:E5E91_RS05755
uniprot id: Q9RV98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

243230:E5E91 RS09880
gene id: 243230:E5E91_RS09880
uniprot id: Q9RT02
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

243230:E5E91 RS00595
gene id: 243230:E5E91_RS00595
uniprot id: Q9RY34
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

243230:E5E91 RS03245
gene id: 243230:E5E91_RS03245
uniprot id: Q9RWN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

243230:E5E91 RS10985
gene id: 243230:E5E91_RS10985
uniprot id: Q9RSE3
names: Similarity
messages: Belongs to the GPN-loop GTPase family.

243230:E5E91 RS03230
gene id: 243230:E5E91_RS03230
uniprot id: Q9RWN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation.
messages: Cytoplasm

243230:E5E91 RS08300
gene id: 243230:E5E91_RS08300
uniprot id: Q7DF83
names: Activity Regulation
names: Cofactor
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Miscellaneous
names: Similarity
names: Subunit
messages: A transposase that is part of insertion sequence (IS) element ISDra2, it is necessary and sufficient for both transposon excision and insertion of ISDra2. This protein alone can be provided in trans and allows transposition of an empty IS element (tnpA or tnpA-tnpB replaced by a selectable marker) (PubMed:16359337, PubMed:20090938). ISDra2 binds subterminal imperfect palindromes at the left (LE) and right (RE) ends of the element and cleaves only the 'top strand' which is circularized and subsequently reinserted into the DNA target. This is called a 'peel and paste' mechanism and increases the copy number of the IS (Probable) (PubMed:20890269). Transposition is linked to DNA replication in the absence of irradiation, with maximal activity when the 'top strand' is on the replication lagging strand, and occurs preferentially on the lagging strand (PubMed:20691900). The IS element inserts 3' of the target sequence 5'-TTGAT-3'; target duplication has not been observed (PubMed:14676423, PubMed:16359337, PubMed:20090938, PubMed:20691900).
messages: Belongs to the IS200/IS605 insertion sequence (IS) element family, formerly called IS8301 (PubMed:14676423, PubMed:20090938). This element is subject to strain polymorphism; in the ATCC 13939 / R1 strain genome sequenced by White there are 7 complete and 1 incomplete IS200/IS605 elements (PubMed:10567266). Another R1 strain has only 1 copy of this element (PubMed:14676423, PubMed:20090938). Another group found 2 copies of this element in untreated R1 strains (PubMed:16359337, PubMed:10567266, PubMed:14676423, PubMed:20090938).
messages: Belongs to the transposase 17 family.
messages: Both the excision and insertion steps are inhibited by TnpB.
messages: Homodimer.
messages: Mg(2+), Mn(2+) and Cd(2+) support DNA cleavage whereas Ca(2+) and Zn(2+) do not.
messages: The helix containing the catalytic Tyr-132 (residues 127-133) is highly mobile. Recognition of the 5-base sequence immediately preceding the cleavage site is mediated by base-pairing to an imperfect palindrome, by sandwiching the fifth nucleotide between Tyr-30 and Trp-107 and hydrogen bonding to His-32, and by main chain atoms of Leu-106 and Trp-107.
messages: Transposition of this element is induced approximately 100-fold by 10 kGy gamma irradiation and approximately 50-fold by 600 J/m(2) of UV irradiation, both of which damage DNA. It rarely transposes without irradiation (PubMed:16359337). Both excision and insertion of ISDra2 are increased by irradiation, transposition occurs in irradiated cells, probably triggered by single-stranded DNA formed during genome reassembly, and is not due to specific induction of TnpA expression (PubMed:20090938).
messages: When tested in an R1 strain with only a single IS200 element (DR_1651 and DR_1652), required for transposition of the IS element; single tnpA or double tnpA-tnpB deletions leads to loss of transposition.

243230:E5E91 RS10100
gene id: 243230:E5E91_RS10100
uniprot id: Q9RSW1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
messages: Belongs to the RimM family.
messages: Binds ribosomal protein uS19.
messages: Cytoplasm
messages: The PRC barrel domain binds ribosomal protein uS19.

243230:E5E91 RS01735
gene id: 243230:E5E91_RS01735
uniprot id: Q9RXH2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

243230:E5E91 RS11150
gene id: 243230:E5E91_RS11150
uniprot id: Q9RSB6
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

243230:E5E91 RS08705
gene id: 243230:E5E91_RS08705
uniprot id: Q9RTN0
names: Cofactor
names: Function
messages: Binds 2 [4Fe-4S] clusters.
messages: Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.

243230:E5E91 RS07550
gene id: 243230:E5E91_RS07550
uniprot id: Q9RU94
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: NDH-1 is composed of 15 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

243230:E5E91 RS05360
gene id: 243230:E5E91_RS05360
uniprot id: Q9RVH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn). Is slightly more efficient at aminoacylating tRNA(Asn) over tRNA(Asp).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Cytoplasm
messages: Homodimer.

243230:E5E91 RS00185
gene id: 243230:E5E91_RS00185
uniprot id: Q9RYB5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

243230:E5E91 RS09105
gene id: 243230:E5E91_RS09105
uniprot id: Q9RTF6
names: Similarity
messages: Belongs to the dGTPase family. Type 2 subfamily.

243230:E5E91 RS05905
gene id: 243230:E5E91_RS05905
uniprot id: Q9RV69
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.
messages: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).
messages: HIU hydrolysis also occurs spontaneously, but more slowly.
messages: Homotetramer.

243230:E5E91 RS07575
gene id: 243230:E5E91_RS07575
uniprot id: Q9RU89
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 49 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 15 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

243230:E5E91 RS10530
gene id: 243230:E5E91_RS10530
uniprot id: Q9RSN2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

243230:E5E91 RS13240
gene id: 243230:E5E91_RS13240
uniprot id: Q9RR76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

243230:E5E91 RS01855
gene id: 243230:E5E91_RS01855
uniprot id: Q9RXE7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnE family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.

243230:E5E91 RS09610
gene id: 243230:E5E91_RS09610
uniprot id: Q9RT57
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LutC/YkgG family.
messages: Homodimer.
messages: May function in L-lactate utilization.

243230:E5E91 RS10305
gene id: 243230:E5E91_RS10305
uniprot id: Q9RSS4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL33 family.
messages: Binds the 23S rRNA and the E site tRNA.
messages: Part of the 50S ribosomal subunit. Contacts protein L35.

243230:E5E91 RS05865
gene id: 243230:E5E91_RS05865
uniprot id: Q9RV75
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M20 family.
messages: Binds 2 Zn(2+) ions per subunit.

243230:E5E91 RS13225
gene id: 243230:E5E91_RS13225
uniprot id: Q9RR78
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
messages: Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
messages: Cell membrane
messages: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.

243230:E5E91 RS07075
gene id: 243230:E5E91_RS07075
uniprot id: Q9RUI7
names: Similarity
messages: Belongs to the flavin oxidoreductase frp family.

243230:E5E91 RS00255
gene id: 243230:E5E91_RS00255
uniprot id: Q9RYA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0702 family.
messages: Cell membrane
messages: Membrane

243230:E5E91 RS15755
gene id: 243230:E5E91_RS15755
uniprot id: Q9RZJ8
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS04400
gene id: 243230:E5E91_RS04400
uniprot id: Q9RW08
names: Similarity
messages: Belongs to the carotenoid/retinoid oxidoreductase family.

243230:E5E91 RS12485
gene id: 243230:E5E91_RS12485
uniprot id: Q9RRL7
names: Function
names: PTM
names: Similarity
messages: Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.

243230:E5E91 RS10290
gene id: 243230:E5E91_RS10290
uniprot id: Q9RSS7
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex (By similarity). Contacts the CTC protein (RL25).

243230:E5E91 RS04390
gene id: 243230:E5E91_RS04390
uniprot id: Q9RW10
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class II aldolase/RraA-like family.
messages: Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).
messages: Divalent metal cation.
messages: Homotrimer.

243230:E5E91 RS05820
gene id: 243230:E5E91_RS05820
uniprot id: Q9RV84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

243230:E5E91 RS06780
gene id: 243230:E5E91_RS06780
uniprot id: Q9RUP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 3B subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

243230:E5E91 RS07985
gene id: 243230:E5E91_RS07985
uniprot id: Q9RU11
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase PH family.
messages: Homohexameric ring arranged as a trimer of dimers.
messages: Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.

243230:E5E91 RS08985
gene id: 243230:E5E91_RS08985
uniprot id: Q9RTH9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.
messages: Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
messages: Cytoplasm
messages: Homodimer.

243230:E5E91 RS15480
gene id: 243230:E5E91_RS15480
uniprot id: Q9RZP7
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

243230:E5E91 RS11975
gene id: 243230:E5E91_RS11975
uniprot id: Q9RRW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

243230:E5E91 RS01395
gene id: 243230:E5E91_RS01395
uniprot id: Q9RXN6
names: Similarity
messages: Belongs to the Nudix hydrolase family.

243230:E5E91 RS12615
gene id: 243230:E5E91_RS12615
uniprot id: Q9RRJ3
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS00030
gene id: 243230:E5E91_RS00030
uniprot id: Q9RYE3
names: Similarity
messages: Belongs to the UPF0173 family.

243230:E5E91 RS14980
gene id: 243230:E5E91_RS14980
uniprot id: Q9RYH4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tryptophan 2,3-dioxygenase family.
messages: Binds 1 heme group per subunit.
messages: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243230:E5E91 RS14530
gene id: 243230:E5E91_RS14530
uniprot id: Q9RYR9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.

243230:E5E91 RS03760
gene id: 243230:E5E91_RS03760
uniprot id: Q9RWD6
names: Similarity
names: Subcellular Location Annotation
messages: Cytoplasm
messages: In the C-terminal section; belongs to the PRA-PH family.
messages: In the N-terminal section; belongs to the PRA-CH family.

243230:E5E91 RS06120
gene id: 243230:E5E91_RS06120
uniprot id: Q9RV25
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.
messages: Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
messages: Cytoplasm

243230:E5E91 RS01240
gene id: 243230:E5E91_RS01240
uniprot id: Q9RXR2
names: Function
names: Similarity
messages: Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
messages: Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.

243230:E5E91 RS14635
gene id: 243230:E5E91_RS14635
uniprot id: Q9RYP7
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS02805
gene id: 243230:E5E91_RS02805
uniprot id: Q9RWW5
names: Similarity
messages: Belongs to the Nudix hydrolase family.

243230:E5E91 RS02055
gene id: 243230:E5E91_RS02055
uniprot id: Q9RXA8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmB/CycW/HelB family.
messages: Cell inner membrane
messages: Membrane
messages: Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.

243230:E5E91 RS15730
gene id: 243230:E5E91_RS15730
uniprot id: Q9RZK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

243230:E5E91 RS03600
gene id: 243230:E5E91_RS03600
uniprot id: Q9RWG8
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity).

243230:E5E91 RS07310
gene id: 243230:E5E91_RS07310
uniprot id: Q9RUD8
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS09700
gene id: 243230:E5E91_RS09700
uniprot id: Q9RT38
names: Activity Regulation
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Inhibited by fructose 1,6-bisphosphate (FBP).
messages: Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

243230:E5E91 RS09845
gene id: 243230:E5E91_RS09845
uniprot id: Q9RT09
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

243230:E5E91 RS15485
gene id: 243230:E5E91_RS15485
uniprot id: Q9RZP6
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.

243230:E5E91 RS04165
gene id: 243230:E5E91_RS04165
uniprot id: Q9RW53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MgtC/SapB family.
messages: Membrane

243230:E5E91 RS11955
gene id: 243230:E5E91_RS11955
uniprot id: Q9RRW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Cell membrane

243230:E5E91 RS04605
gene id: 243230:E5E91_RS04605
uniprot id: Q9RVW9
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

243230:E5E91 RS04770
gene id: 243230:E5E91_RS04770
uniprot id: Q9RVT6
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

243230:E5E91 RS11900
gene id: 243230:E5E91_RS11900
uniprot id: Q9RRX5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

243230:E5E91 RS15860
gene id: 243230:E5E91_RS15860
uniprot id: Q9RZH9
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

243230:E5E91 RS00360
gene id: 243230:E5E91_RS00360
uniprot id: Q9RY80
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Subunit
messages: Cells lacking this gene show a normal growth rate, do not exhibit a decrease in the efficiency of natural transformation, but display a reduced capacity to survive ionizing radiation when exposed at doses superior to 2.5 kGy. DNA repair following irradiations is slower. Cannot be complemented by ssb. A double recA-ddrB disruption shows no signs of DNA repair 24 hours after irradiation.
messages: Contains a novel ssDNA-binding fold, which is structurally and topologically distinct from the OB-fold universally found in standard SSB proteins. The disordered C-terminus of DdrB may mediate interactions with other proteins important for DNA damage recovery (By similarity).
messages: Homopentamer arranged in a ring-structure; DNA binds between subunits and along the top of the ring. The pentamers self-associate to coat ssDNA in higher-ordered structures; oligomerization facilitates the assembly of extended nucleoprotein complexes. Self-assembly does not however require ssDNA-binding. Interacts with SSB.
messages: Induced to high levels following extreme ionizing radiation exposure. Also highly induced in response to desiccation stress.
messages: ssDNA-binding protein that contributes to the ionizing radiation resistance of D.radiodurans. Plays a role in DNA repair and genome reconstitution in a RecA-independent process. Required for recovery from severe genomic fragmentation as a result of exposure to severe levels of ionizing radiation. Binds ssDNA but not dsDNA. Stimulates annealing of complementary ssDNA. Does not complement an ssb disruption.

243230:E5E91 RS07555
gene id: 243230:E5E91_RS07555
uniprot id: Q9RU93
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the complex I 75 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

243230:E5E91 RS03580
gene id: 243230:E5E91_RS03580
uniprot id: Q9RWH2
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS07295
gene id: 243230:E5E91_RS07295
uniprot id: Q9RUE2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATP phosphoribosyltransferase family. Short subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity).
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Lacks the C-terminal regulatory region which is replaced by HisZ.

243230:E5E91 RS07910
gene id: 243230:E5E91_RS07910
uniprot id: Q9RU24
names: Function
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.
messages: Probably part of a binding-protein-dependent transport system.

243230:E5E91 RS03365
gene id: 243230:E5E91_RS03365
uniprot id: Q9RWL2
names: Similarity
messages: Belongs to the peptidase S33 family.

243230:E5E91 RS10295
gene id: 243230:E5E91_RS10295
uniprot id: Q9RSS6
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

243230:E5E91 RS03070
gene id: 243230:E5E91_RS03070
uniprot id: Q9RWR9
names: Similarity
messages: Belongs to the SCO1/2 family.

243230:E5E91 RS12450
gene id: 243230:E5E91_RS12450
uniprot id: Q9RRM4
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

243230:E5E91 RS10375
gene id: 243230:E5E91_RS10375
uniprot id: Q9RSR5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of glycine to tRNA(Gly).
messages: Cytoplasm
messages: Homodimer.

243230:E5E91 RS10285
gene id: 243230:E5E91_RS10285
uniprot id: Q9RSS8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Forms the L1 stalk. Unlike the case in the Thermus thermophilus 70S ribosome, this protein is not seen to block the exit path of the E site tRNA. It is clear that the protein in the structure is flexible however, so this is probably due to its position in these crystals.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

243230:E5E91 RS14850
gene id: 243230:E5E91_RS14850
uniprot id: Q9RYJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreF family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

243230:E5E91 RS08495
gene id: 243230:E5E91_RS08495
uniprot id: Q9RTR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Monomer.

243230:E5E91 RS12345
gene id: 243230:E5E91_RS12345
uniprot id: Q9RRP6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

243230:E5E91 RS11965
gene id: 243230:E5E91_RS11965
uniprot id: Q9RRW5
names: Cofactor
names: Miscellaneous
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.

243230:E5E91 RS11625
gene id: 243230:E5E91_RS11625
uniprot id: Q9RS27
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

243230:E5E91 RS10645
gene id: 243230:E5E91_RS10645
uniprot id: Q9RSL0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Binds the 5S and 23S rRNAs.
messages: Part of the 50S ribosomal subunit.

243230:E5E91 RS07940
gene id: 243230:E5E91_RS07940
uniprot id: Q9RU19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

243230:E5E91 RS00845
gene id: 243230:E5E91_RS00845
uniprot id: Q9RXY9
names: Similarity
messages: Belongs to the peptidase S9C family.

243230:E5E91 RS14080
gene id: 243230:E5E91_RS14080
uniprot id: Q9RZ05
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.
messages: Binds 1 zinc or iron ion per subunit.
messages: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.
messages: Cytoplasm

243230:E5E91 RS04590
gene id: 243230:E5E91_RS04590
uniprot id: Q9RVX2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H family.
messages: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Monomer.

243230:E5E91 RS14105
gene id: 243230:E5E91_RS14105
uniprot id: Q9RZ00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DedA family.
messages: Cell membrane
messages: Membrane

243230:E5E91 RS00070
gene id: 243230:E5E91_RS00070
uniprot id: Q9RYD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

243230:E5E91 RS04495
gene id: 243230:E5E91_RS04495
uniprot id: Q9RVY9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

243230:E5E91 RS14715
gene id: 243230:E5E91_RS14715
uniprot id: Q9RYN1
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS08740
gene id: 243230:E5E91_RS08740
uniprot id: Q9RTM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

243230:E5E91 RS12060
gene id: 243230:E5E91_RS12060
uniprot id: Q9RRU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A8 family.
messages: Cell membrane
messages: This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

243230:E5E91 RS06860
gene id: 243230:E5E91_RS06860
uniprot id: Q9RUN0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

243230:E5E91 RS03325
gene id: 243230:E5E91_RS03325
uniprot id: Q9RWM1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

243230:E5E91 RS11330
gene id: 243230:E5E91_RS11330
uniprot id: Q9RS84
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

243230:E5E91 RS01875
gene id: 243230:E5E91_RS01875
uniprot id: Q9RXE3
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnA subfamily.
messages: Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

243230:E5E91 RS06480
gene id: 243230:E5E91_RS06480
uniprot id: Q9RUV6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

243230:E5E91 RS04585
gene id: 243230:E5E91_RS04585
uniprot id: Q9RVX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

243230:E5E91 RS00395
gene id: 243230:E5E91_RS00395
uniprot id: Q9RY74
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

243230:E5E91 RS04510
gene id: 243230:E5E91_RS04510
uniprot id: Q9RVY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
messages: Cell membrane
messages: Membrane

243230:E5E91 RS09015
gene id: 243230:E5E91_RS09015
uniprot id: Q9RTH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate synthase component I family.
messages: Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).
messages: Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.

243230:E5E91 RS14975
gene id: 243230:E5E91_RS14975
uniprot id: Q9RYH5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
messages: Homodimer.

243230:E5E91 RS14600
gene id: 243230:E5E91_RS14600
uniprot id: Q9RYQ4
names: Similarity
messages: Belongs to the peptidase S45 family.

243230:E5E91 RS14030
gene id: 243230:E5E91_RS14030
uniprot id: Q9RZ15
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243230:E5E91 RS11030
gene id: 243230:E5E91_RS11030
uniprot id: Q9RSD7
names: Similarity
messages: Belongs to the CFA/CMAS family.

243230:E5E91 RS02875
gene id: 243230:E5E91_RS02875
uniprot id: Q9RWV3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.
messages: Cell membrane
messages: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.

243230:E5E91 RS03860
gene id: 243230:E5E91_RS03860
uniprot id: Q9RWB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DsbB family. BdbC subfamily.
messages: Cell membrane
messages: Required for disulfide bond formation in some proteins.

243230:E5E91 RS06475
gene id: 243230:E5E91_RS06475
uniprot id: Q9RUV7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

243230:E5E91 RS09430
gene id: 243230:E5E91_RS09430
uniprot id: Q9RT91
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

243230:E5E91 RS02230
gene id: 243230:E5E91_RS02230
uniprot id: Q9RX75
names: Cofactor
names: Disruption Phenotype
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds HJ DNA independently of homologous core or consensus sequence; Mn(2+) is not essential for binding but improves it, while >1.0 mM Mg(2+) inhibit binding. Also binds Y-junction DNA less well. Requires a homologous core to cleave DNA (PubMed:35744678). Another study shows divalent cations (Mn(2+), Mg(2+) and Ca(2+), tested up to 5.0 mM) improve DNA binding considerably over binding in their absence (PubMed:36000732).
messages: Cytoplasm
messages: D.radiodurans metalloenzymes exhibit a strong preference for Mn(2+) rather than Mg(2+).
messages: Homodimer which binds Holliday junction (HJ) DNA (PubMed:35744678). The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: In vitro only Mn(2+) supports endonuclease activity; Mg(2+) inhibits binding to HJ DNA (PubMed:35744678). Another study shows Mn(2+) is the preferred cofactor but Mg(2+) does support cleavage (PubMed:36000732). Binds 2 Mn(2+) ion per subunit (By similarity).
messages: Only heterozygous strains can be obtained, suggesting this gene is essential.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair (PubMed:36000732). Endonuclease that resolves HJ intermediates (PubMed:35744678, PubMed:36000732). Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, probably yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction (PubMed:35744678, PubMed:36000732). The consensus cleavage sequence is 5'-(G/C)TC(C/G)-3' (a different site than E.coli); cleavage occurs on the 3'-side of the TC dinucleotide at the point of strand exchange (PubMed:36000732). Also resolves nicked HJ intermediates, replication forks and Y-junction DNA in vitro (PubMed:36000732). HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA (By similarity).

243230:E5E91 RS01175
gene id: 243230:E5E91_RS01175
uniprot id: Q9RXS5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243230:E5E91 RS02975
gene id: 243230:E5E91_RS02975
uniprot id: Q9RWT6
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243230:E5E91 RS12750
gene id: 243230:E5E91_RS12750
uniprot id: Q9RRG8
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL28 family.
messages: Part of the 50S ribosomal subunit.

243230:E5E91 RS10780
gene id: 243230:E5E91_RS10780
uniprot id: Q9RSI2
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS08900
gene id: 243230:E5E91_RS08900
uniprot id: Q9RTJ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.

243230:E5E91 RS06615
gene id: 243230:E5E91_RS06615
uniprot id: Q9RUS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243230:E5E91 RS07595
gene id: 243230:E5E91_RS07595
uniprot id: Q9RU85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane

243230:E5E91 RS15015
gene id: 243230:E5E91_RS15015
uniprot id: O32506
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase S24 family.
messages: Homodimer.
messages: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

243230:E5E91 RS00440
gene id: 243230:E5E91_RS00440
uniprot id: Q9RY66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

243230:E5E91 RS06255
gene id: 243230:E5E91_RS06255
uniprot id: Q9RUZ8
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Periplasm

243230:E5E91 RS00865
gene id: 243230:E5E91_RS00865
uniprot id: Q9RXY5
names: Function
names: Similarity
messages: Belongs to the DHNA family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin.

243230:E5E91 RS12900
gene id: 243230:E5E91_RS12900
uniprot id: Q9RRD7
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

243230:E5E91 RS13470
gene id: 243230:E5E91_RS13470
uniprot id: Q9RZC5
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.

243230:E5E91 RS09120
gene id: 243230:E5E91_RS09120
uniprot id: Q9RTF3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

243230:E5E91 RS02290
gene id: 243230:E5E91_RS02290
uniprot id: Q9RX63
names: Similarity
messages: Belongs to the barstar family.

243230:E5E91 RS00015
gene id: 243230:E5E91_RS00015
uniprot id: Q9RYE6
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: Sequence Caution
names: Subcellular Location Annotation
names: Subunit
messages: Appears to contribute to D.radiodurans capacity to survive exposure to ionizing radiation (PubMed:15454524). Likely functions as a DNA damage-induced nucleoid-associated protein (NAP) that contributes to the enhanced level of nucleoid compaction after irradiation by bridging DNA duplexes, thereby limiting the dispersion of the fragmented genome immediately after irradiation to facilitate subsequent DNA repair. In vitro, binds both ssDNA and dsDNA, and is able to compact circular DNA, circularize linear DNA, anneal complementary DNA strands and protect DNA from nucleases (PubMed:35801857, PubMed:28542368).
messages: Cells lacking this gene show a normal growth rate, do not exhibit a decrease in the efficiency of natural transformation, and is as resistant to ionizing radiation as wild-type. However, deletion of the ddrC gene decreases the ionizing radiation resistance of the ddrB mutant strain or the recA mutant strain, and appears to increase that of the pprA mutant strain. Moreover, cells lacking both ddrC and ddrD exhibit a slight (two-fold) increase in sensitivity to ionizing radiation, but this phenotype is apparent only at the highest applied doses (PubMed:15454524). The ddrC deletion mutant is 10 times more ssensitive to high doses of UV radiation than wild-type cells, and the ddrC deletion significantly increases UV-sensitivity of uvrA or uvsE deletion mutant strains (PubMed:28542368).
messages: Homodimer.
messages: Induced to high levels following extreme ionizing radiation exposure (PubMed:15454524, PubMed:28542368). Is induced after gamma-irradiation in an IrrE/DdrO dependent manner (PubMed:28542368). Also highly induced in response to desiccation stress (PubMed:15454524).
messages: Is composed of two domains, an unusual N-terminal wHTH motif and a more classical four-helix bundle at its C-terminus, which is domain swapped in the DdrC homodimer. The domain swapping creates an asymmetric dimer exhibiting two distinct DNA binding surfaces corresponding to a high- and a low-affinity DNA binding site.
messages: Was originally predicted on the opposite strand.
messages: nucleoid

243230:E5E91 RS07625
gene id: 243230:E5E91_RS07625
uniprot id: Q9RU79
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

243230:E5E91 RS11530
gene id: 243230:E5E91_RS11530
uniprot id: Q9RS45
names: Similarity
messages: Belongs to the UPF0102 family.

243230:E5E91 RS15140
gene id: 243230:E5E91_RS15140
uniprot id: Q9RZV8
names: Similarity
messages: Belongs to the ParB family.

243230:E5E91 RS03595
gene id: 243230:E5E91_RS03595
uniprot id: Q9RWG9
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

243230:E5E91 RS10830
gene id: 243230:E5E91_RS10830
uniprot id: Q9RSH2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL34 family.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Contacts protein L4.

243230:E5E91 RS03330
gene id: 243230:E5E91_RS03330
uniprot id: Q9RWM0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer.

243230:E5E91 RS11100
gene id: 243230:E5E91_RS11100
uniprot id: Q9RSC5
names: Similarity
messages: Belongs to the OMP decarboxylase family. Type 2 subfamily.

243230:E5E91 RS06980
gene id: 243230:E5E91_RS06980
uniprot id: Q9RUK6
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.

243230:E5E91 RS08570
gene id: 243230:E5E91_RS08570
uniprot id: Q9RTQ2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e. capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

243230:E5E91 RS08955
gene id: 243230:E5E91_RS08955
uniprot id: Q9RTI6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

243230:E5E91 RS00670
gene id: 243230:E5E91_RS00670
uniprot id: Q9RY21
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.

243230:E5E91 RS01600
gene id: 243230:E5E91_RS01600
uniprot id: Q9RXJ8
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

243230:E5E91 RS01250
gene id: 243230:E5E91_RS01250
uniprot id: Q9RXR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

243230:E5E91 RS00815
gene id: 243230:E5E91_RS00815
uniprot id: Q9RXZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uridine kinase family.
messages: Cytoplasm

243230:E5E91 RS05085
gene id: 243230:E5E91_RS05085
uniprot id: Q9RVM9
names: Function
names: Similarity
names: Subunit
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

243230:E5E91 RS14335
gene id: 243230:E5E91_RS14335
uniprot id: Q9RYV6
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

243230:E5E91 RS12305
gene id: 243230:E5E91_RS12305
uniprot id: Q9RRQ3
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

243230:E5E91 RS00430
gene id: 243230:E5E91_RS00430
uniprot id: Q9RY67
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the 2-oxoacid dehydrogenase family.
messages: Binds 1 lipoyl cofactor covalently.
messages: E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).

243230:E5E91 RS06930
gene id: 243230:E5E91_RS06930
uniprot id: Q9RUL6
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

243230:E5E91 RS01595
gene id: 243230:E5E91_RS01595
uniprot id: Q9RXJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome (By similarity).
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome (By similarity).

243230:E5E91 RS03755
gene id: 243230:E5E91_RS03755
uniprot id: Q9RWD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).

243230:E5E91 RS10685
gene id: 243230:E5E91_RS10685
uniprot id: Q9RSK2
names: Similarity
messages: Belongs to the leucine-binding protein family.

243230:E5E91 RS13665
gene id: 243230:E5E91_RS13665
uniprot id: Q9RZ86
names: Similarity
messages: Belongs to the 3-oxoacid CoA-transferase subunit A family.

243230:E5E91 RS14085
gene id: 243230:E5E91_RS14085
uniprot id: Q9RZ04
names: Similarity
messages: Belongs to the arginase family.

243230:E5E91 RS05595
gene id: 243230:E5E91_RS05595
uniprot id: Q9RVC9
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

243230:E5E91 RS09450
gene id: 243230:E5E91_RS09450
uniprot id: Q9RT87
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

243230:E5E91 RS11035
gene id: 243230:E5E91_RS11035
uniprot id: Q9RSD6
names: Similarity
messages: Belongs to the peptidase M29 family.

243230:E5E91 RS08140
gene id: 243230:E5E91_RS08140
uniprot id: Q9RTY0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

243230:E5E91 RS04800
gene id: 243230:E5E91_RS04800
uniprot id: Q9RVT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

243230:E5E91 RS05960
gene id: 243230:E5E91_RS05960
uniprot id: Q9RV58
names: Similarity
messages: Belongs to the LEA type 1 family.

243230:E5E91 RS02395
gene id: 243230:E5E91_RS02395
uniprot id: Q9RX45
names: Similarity
messages: Belongs to the PHP hydrolase family. HisK subfamily.

243230:E5E91 RS07820
gene id: 243230:E5E91_RS07820
uniprot id: Q9RU41
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
messages: Cytoplasm
messages: Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.

243230:E5E91 RS05645
gene id: 243230:E5E91_RS05645
uniprot id: Q9RVB9
names: Function
names: Similarity
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.

243230:E5E91 RS09245
gene id: 243230:E5E91_RS09245
uniprot id: Q9RTD0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane

243230:E5E91 RS05010
gene id: 243230:E5E91_RS05010
uniprot id: Q9RVP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Cell membrane
messages: Membrane

243230:E5E91 RS02460
gene id: 243230:E5E91_RS02460
uniprot id: Q9RX32
names: Similarity
messages: Belongs to the UPF0225 family.

243230:E5E91 RS02285
gene id: 243230:E5E91_RS02285
uniprot id: Q9RX64
names: Similarity
messages: Belongs to the glutamine synthetase family.

243230:E5E91 RS14185
gene id: 243230:E5E91_RS14185
uniprot id: Q9RYY4
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

243230:E5E91 RS08840
gene id: 243230:E5E91_RS08840
uniprot id: Q9RTK4
names: Similarity
messages: Belongs to the peptidase S1C family.

243230:E5E91 RS06040
gene id: 243230:E5E91_RS06040
uniprot id: Q9RV42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

243230:E5E91 RS00860
gene id: 243230:E5E91_RS00860
uniprot id: Q9RXY6
names: Function
names: Similarity
messages: Belongs to the DHPS family.
messages: Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.

243230:E5E91 RS01885
gene id: 243230:E5E91_RS01885
uniprot id: Q9RXE1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

243230:E5E91 RS08490
gene id: 243230:E5E91_RS08490
uniprot id: Q9RTR7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.
messages: Homotetramer.
messages: Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.

243230:E5E91 RS04930
gene id: 243230:E5E91_RS04930
uniprot id: Q9RVQ4
names: Similarity
messages: Belongs to the methylenetetrahydrofolate reductase family.

243230:E5E91 RS15095
gene id: 243230:E5E91_RS15095
uniprot id: Q9RYF8
names: Similarity
messages: Belongs to the threonine synthase family.

243230:E5E91 RS14550
gene id: 243230:E5E91_RS14550
uniprot id: Q9RYR5
names: Cofactor
names: Domain
names: Similarity
messages: Belongs to the globin family. Two-domain flavohemoproteins subfamily.
messages: Binds 1 FAD per subunit.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Consists of two distinct domains; an N-terminal heme-containing oxygen-binding domain and a C-terminal reductase domain with binding sites for FAD and NAD(P)H.
messages: In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

243230:E5E91 RS13155
gene id: 243230:E5E91_RS13155
uniprot id: Q9RR90
names: Function
names: Similarity
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).

243230:E5E91 RS03585
gene id: 243230:E5E91_RS03585
uniprot id: Q9RWH1
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

243230:E5E91 RS04180
gene id: 243230:E5E91_RS04180
uniprot id: Q9RW50
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

243230:E5E91 RS01430
gene id: 243230:E5E91_RS01430
uniprot id: Q9RXM9
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS08910
gene id: 243230:E5E91_RS08910
uniprot id: Q9RTJ3
names: Disruption Phenotype
names: Domain
names: Function
messages: Contains an N-terminal PQQ binding domain and a C-terminal disorganized low-complexity (LC) hydrophilic region.
messages: Mutant is sensitive to gamma radiation and hypersensitive to desiccation. It shows delayed DNA double-strand break repair and delayed recovery of desiccated nucleoid.
messages: Plays an important role in resistance to desiccation and radiation, maybe by protecting genome integrity under extreme conditions.

243230:E5E91 RS09205
gene id: 243230:E5E91_RS09205
uniprot id: Q9RTD8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate 5-kinase family.
messages: Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
messages: Cytoplasm

243230:E5E91 RS02310
gene id: 243230:E5E91_RS02310
uniprot id: Q9RX59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Membrane

243230:E5E91 RS00855
gene id: 243230:E5E91_RS00855
uniprot id: Q9RXY7
names: Caution
names: Disruption Phenotype
names: Domain
names: Function
messages: Composed of three structural domains: an N-terminal zinc-peptidase domain, a central helix-turn-helix motif, and a C-terminal GAF-type domain.
messages: It is uncertain whether Met-1 or Val-41 is the initiator.
messages: Mutant is sensitive to ionizing radiation, UV light and mitomycin C.
messages: Plays a central regulatory role in DNA repair and protection pathways in response to radiation stress (PubMed:12804570, PubMed:22051194). Acts as a site-specific metalloprotease that cleaves and inactivates the repressor protein DdrO, resulting in induced expression of genes required for DNA repair and cell survival after exposure to radiation (By similarity). Regulates the expression of dozens of proteins from different pathways, including the important DNA repair proteins RecA and PprA (PubMed:12399492, PubMed:12804570, PubMed:22051194). Binds to the promoters of recA and pprA (PubMed:22051194).

243230:E5E91 RS02550
gene id: 243230:E5E91_RS02550
uniprot id: Q9RX15
names: Function
messages: May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.

243230:E5E91 RS13160
gene id: 243230:E5E91_RS13160
uniprot id: Q9RR89
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.
messages: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.

243230:E5E91 RS02415
gene id: 243230:E5E91_RS02415
uniprot id: Q9RX41
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS06020
gene id: 243230:E5E91_RS06020
uniprot id: Q9RV46
names: Similarity
names: Subunit
messages: Belongs to the Nudix hydrolase family. PCD1 subfamily.
messages: Monomer.

243230:E5E91 RS12235
gene id: 243230:E5E91_RS12235
uniprot id: Q9RRR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MscL family.
messages: Cell membrane
messages: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
messages: Homopentamer.
messages: Membrane

243230:E5E91 RS09755
gene id: 243230:E5E91_RS09755
uniprot id: Q9RT27
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

243230:E5E91 RS13210
gene id: 243230:E5E91_RS13210
uniprot id: Q9RR81
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

243230:E5E91 RS01655
gene id: 243230:E5E91_RS01655
uniprot id: Q9RXI7
names: Disruption Phenotype
names: Function
names: Induction
messages: Appears to contribute to D.radiodurans capacity to survive exposure to ionizing radiation. May play a role in DNA repair and genome reconstitution.
messages: Cells lacking this gene show a normal growth rate, do not exhibit a decrease in the efficiency of natural transformation, and is as resistant to ionizing radiation as wild-type. However, deletion of the ddrC gene decreases the ionizing radiation resistance of the recA mutant strain, and appears to increase that of the pprA mutant strain. Moreover, cells lacking both ddrC and ddrD exhibit a slight (two-fold) increase in sensitivity to ionizing radiation, but this phenotype is apparent only at the highest applied doses.
messages: Induced to high levels following extreme ionizing radiation exposure. Also highly induced in response to desiccation stress.

243230:E5E91 RS08535
gene id: 243230:E5E91_RS08535
uniprot id: Q9RTQ8
names: Caution
names: Function
names: Similarity
messages: Belongs to the Dus family. DusA subfamily.
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243230:E5E91 RS00145
gene id: 243230:E5E91_RS00145
uniprot id: Q9RYC3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

243230:E5E91 RS09335
gene id: 243230:E5E91_RS09335
uniprot id: Q9RTB1
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS01845
gene id: 243230:E5E91_RS01845
uniprot id: Q9RXE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

243230:E5E91 RS09595
gene id: 243230:E5E91_RS09595
uniprot id: Q9RT59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lactate permease family.
messages: Cell membrane
messages: Membrane
messages: Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate.

243230:E5E91 RS15570
gene id: 243230:E5E91_RS15570
uniprot id: Q9RZN1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Dps family.
messages: Cytoplasm
messages: Homododecamer. The 12 subunits form a hollow sphere into which the mineral iron core of up to 500 Fe(3+) can be deposited (By similarity).
messages: Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction (By similarity).

243230:E5E91 RS14215
gene id: 243230:E5E91_RS14215
uniprot id: Q9RYX8
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

243230:E5E91 RS01170
gene id: 243230:E5E91_RS01170
uniprot id: Q9RXS6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IspF family.
messages: Binds 1 divalent metal cation per subunit.
messages: Homotrimer.
messages: Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).

243230:E5E91 RS07395
gene id: 243230:E5E91_RS07395
uniprot id: Q9RUC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

243230:E5E91 RS13975
gene id: 243230:E5E91_RS13975
uniprot id: Q9RZ27
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

243230:E5E91 RS00130
gene id: 243230:E5E91_RS00130
uniprot id: Q9RYC6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PurK/PurT family.
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
messages: Homodimer.

243230:E5E91 RS11535
gene id: 243230:E5E91_RS11535
uniprot id: Q9RS44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

243230:E5E91 RS15025
gene id: 243230:E5E91_RS15025
uniprot id: O32504
names: Activity Regulation
names: Biotechnology
names: Disruption Phenotype
names: Function
names: Induction
names: PTM
messages: Cells lacking this gene show a reduced growth rate, do not exhibit a decrease in the efficiency of natural transformation, but are much more sensitive to ionizing radiation than the wild-type strain.
messages: Induced to high levels following extreme ionizing radiation exposure. Also highly induced in response to desiccation stress.
messages: Phosphorylated by RqkA in vitro. Phosphorylated primarily at Thr-88, and to a little extent at Ser-128 and Thr-160.
messages: Phosphorylation increases DNA binding affinity.
messages: The PprA protein combined with an immunofluorescence technique can be used to visualize radiation-induced DNA strand breaks in mammalian cultured cells, allowing the evaluation of DNA damage responses. This detection method could also be applicable to genotoxic tests in the environmental and pharmaceutical fields.
messages: dsDNA-binding protein that contributes to the ionizing radiation resistance of D.radiodurans. Plays a role in DNA repair and genome reconstitution, and is necessary for recovery from severe genomic fragmentation as a result of exposure to severe levels of ionizing radiation. In vitro, binds to double-stranded DNA carrying strand breaks and stimulates the DNA end-joining reaction catalyzed by DNA ligases. Thus, PprA plays a critical role in a non-homologous end-joining (NHEJ) pathway for the repair of radiation-induced DNA double-strands breaks. Cannot bind to dsDNA without strand breaks or single-stranded DNA.

243230:E5E91 RS10165
gene id: 243230:E5E91_RS10165
uniprot id: Q9RSV0
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

243230:E5E91 RS12690
gene id: 243230:E5E91_RS12690
uniprot id: Q9RRH9
names: Similarity
messages: Belongs to the RutC family.

243230:E5E91 RS11700
gene id: 243230:E5E91_RS11700
uniprot id: Q9RS12
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS09770
gene id: 243230:E5E91_RS09770
uniprot id: Q9RT24
names: Similarity
messages: Belongs to the fabD family.

243230:E5E91 RS12625
gene id: 243230:E5E91_RS12625
uniprot id: Q9RRJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

243230:E5E91 RS01150
gene id: 243230:E5E91_RS01150
uniprot id: Q9RXT0
names: Similarity
messages: Belongs to the SAICAR synthetase family.

243230:E5E91 RS09905
gene id: 243230:E5E91_RS09905
uniprot id: Q9RSZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

243230:E5E91 RS13005
gene id: 243230:E5E91_RS13005
uniprot id: Q9RRB6
names: Caution
names: Disruption Phenotype
names: Domain
names: Function
names: Miscellaneous
names: Subcellular Location Annotation
names: Subunit
messages: Cell envelope
messages: Cell outer membrane
messages: D.radiodurans possesses an atypical cell envelope comprising an inner membrane, a large periplasmic space with a thick peptidoglycan (PG) layer, and an outer membrane (OM) covered by a surface layer (S-layer).
messages: Deletion causes substantial alterations in cell envelope structure, and a significant defect in resistance to solvent and shear stresses. Mutants shed exterior layers of the cellular envelope (PubMed:16946272). Deletion mutants show a significant decrease of the UV resistance, especially under desiccation conditions (PubMed:26909071). Deletions mutants show large disruptions in the OM, but the S-layer is unchanged compared to wild-type cells (PubMed:35943982).
messages: Homotrimer (PubMed:35577074, PubMed:35943982). Part of a heterooligomeric complex resulting in the main assembly named S-layer deinoxanthin-binding complex (SDBC) which is composed of six different subunits, namely SlpA, DR_2310, DR_0505, DR_A0283, DR_A0282, and DR_A0281 (PubMed:32071085).
messages: Plays an important role in the structural organization and integrity of the cell envelope, bridging the outer membrane to the peptidoglyan layer (PubMed:16946272, PubMed:26074883, PubMed:35943982). Is a highly abundant molecule in the D.radiodurans cell envelope but is not a fundamental component of the S-layer (PubMed:35943982). Binds the carotenoid deinoxanthin, a strong protective antioxidant specific of this bacterium, and could be part of the first lane of defense against UV radiation, especially under desiccation (PubMed:26909071). Appears to be a nonselective channel (PubMed:32071085). Is able to transport charged amino acids such as Lys, Arg and Glu; the large dimension of the pore points toward the physiological importance of the SDBC complex in assisting and allowing the exchange of substances, including nutrients, with the surrounding environment (PubMed:35577074).
messages: The structure is characterized by a pore region with a massive beta-barrel organization which is embedded in the outer membrane and shows some protrusions into the S-layer, a stalk region consisting of a trimeric coiled coil, and a collar region at the base of the stalk (PubMed:35577074). More precisely, SlpA exhibits a tripartite organization, with its C-terminal part forming a homotrimeric 30-stranded OM beta-barrel (OMBB), its central part forming a long trimeric coiled coil that can traverse the large periplasmic space, and the extreme N-terminal part forming an SLH domain trimer that can interact with the PG layer (PubMed:35943982).
messages: Was originally thought to be a major constituent of the S-layer. However, structural and deletion mutant studies showed that SlpA is an outer membrane protein and is not an integral part of the S-layer (PubMed:35943982).

243230:E5E91 RS14400
gene id: 243230:E5E91_RS14400
uniprot id: Q9RYU5
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.
messages: Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
messages: Homodimer.
messages: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.

243230:E5E91 RS12070
gene id: 243230:E5E91_RS12070
uniprot id: Q9RRU5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

243230:E5E91 RS03575
gene id: 243230:E5E91_RS03575
uniprot id: Q9RWH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

243230:E5E91 RS10025
gene id: 243230:E5E91_RS10025
uniprot id: Q9RSX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

243230:E5E91 RS01620
gene id: 243230:E5E91_RS01620
uniprot id: Q9RXJ4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL29 family.
messages: Binds the 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: Part of the 50S ribosomal subunit. Contacts protein L23 and trigger factor when it is complexed with the ribosome (PubMed:16091460, PubMed:16271892).

243230:E5E91 RS02885
gene id: 243230:E5E91_RS02885
uniprot id: Q9RWV1
names: Similarity
messages: Belongs to the bacterial solute-binding protein 3 family.

243230:E5E91 RS10090
gene id: 243230:E5E91_RS10090
uniprot id: Q9RSW3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243230:E5E91 RS13535
gene id: 243230:E5E91_RS13535
uniprot id: Q9RZB2
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

243230:E5E91 RS15040
gene id: 243230:E5E91_RS15040
uniprot id: Q9RYG8
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS10675
gene id: 243230:E5E91_RS10675
uniprot id: Q9RSK4
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS00970
gene id: 243230:E5E91_RS00970
uniprot id: Q9RXW5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

243230:E5E91 RS14180
gene id: 243230:E5E91_RS14180
uniprot id: Q9RYY5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

243230:E5E91 RS02935
gene id: 243230:E5E91_RS02935
uniprot id: Q9RWU4
names: Similarity
messages: Belongs to the ETF-QO/FixC family.

243230:E5E91 RS02300
gene id: 243230:E5E91_RS02300
uniprot id: Q9RX61
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane

243230:E5E91 RS03050
gene id: 243230:E5E91_RS03050
uniprot id: Q9RWS1
names: Function
names: Similarity
messages: Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.
messages: Synthesizes alpha-1,4-glucan chains using ADP-glucose.

243230:E5E91 RS10340
gene id: 243230:E5E91_RS10340
uniprot id: Q9RSS2
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS05940
gene id: 243230:E5E91_RS05940
uniprot id: Q9RV62
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Nudix hydrolase family. NudC subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Divalent metal cations. Mg(2+) or Mn(2+).
messages: Homodimer.
messages: mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some mRNAs and stabilizes RNA against 5'-processing. Has preference for mRNAs with a 5'-end purine. Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates.

243230:E5E91 RS14310
gene id: 243230:E5E91_RS14310
uniprot id: Q9RYW1
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

243230:E5E91 RS03610
gene id: 243230:E5E91_RS03610
uniprot id: Q9RWG6
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

243230:E5E91 RS04685
gene id: 243230:E5E91_RS04685
uniprot id: Q9RVV1
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

243230:E5E91 RS06970
gene id: 243230:E5E91_RS06970
uniprot id: Q9RUK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm

243230:E5E91 RS06055
gene id: 243230:E5E91_RS06055
uniprot id: Q9RV39
names: Function
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
messages: tRNA nucleotidyltransferase involved in the synthesis of the tRNA CCA terminus. Adds the terminal adenosine residue to tRNA.

243230:E5E91 RS00515
gene id: 243230:E5E91_RS00515
uniprot id: Q9RY51
names: Disruption Phenotype
names: Function
names: Induction
names: Subcellular Location Annotation
names: Subunit
messages: Constitutively expressed, highly up-regulated following ionizing radiation for at least 12 hours (at protein level).
messages: Cytoplasm
messages: Essential, it cannot be knocked out. As SSB levels are depleted growth slows, tolerance to ionizing radiation and UV light decreases rapidly. Cannot be complemented by ddrB.
messages: Homodimer. Binds ssDNA. Interacts with DdrB.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism (By similarity). Essential for ionizing radiation resistance. Stimulates the 5'-3' DNA helicase activity of RecD-like helicase. Stimulates RecA protein-promoted DNA three-strand exchange reactions in vitro with both D.radiodurans and E.coli-derived RecA. Complements an ssb deletion in E.coli, but does not complement a ddrb disruption in D.radiodurans.

243230:E5E91 RS00900
gene id: 243230:E5E91_RS00900
uniprot id: Q9RXX9
names: Similarity
messages: Belongs to the peptidase S13 family.

243230:E5E91 RS08980
gene id: 243230:E5E91_RS08980
uniprot id: Q9RTI0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

243230:E5E91 RS02240
gene id: 243230:E5E91_RS02240
uniprot id: Q9RX73
names: Similarity
messages: Belongs to the GSP E family.

243230:E5E91 RS00525
gene id: 243230:E5E91_RS00525
uniprot id: Q9RY49
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA and protein L31.
messages: Part of the 50S ribosomal subunit. Contacts protein L31.

243230:E5E91 RS09575
gene id: 243230:E5E91_RS09575
uniprot id: Q9RT63
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the RecD family. RecD-like subfamily.
messages: DNA-dependent ATPase (ssDNA better than dsDNA) and ATP-dependent 5'-3' DNA helicase. Appears to move along DNA in single base steps, powered by hydrolysis of 1 molecule of ATP. Has low processivity; short (20 bp) substrates with 5'-overhangs or forked ends are the best substrates, is much less efficient on 52 or 76 bp substrates with 5'- overhangs. The presence of single-stranded DNA-binding protein (SSB) increases unwinding 4-5 fold. Has no activity on blunt DNA or DNA with 3'-overhangs. Requires at least 10 bases of 5'-ssDNA for helicase activity.
messages: There are no RecB or RecC orthologs in this organism.

243230:E5E91 RS05545
gene id: 243230:E5E91_RS05545
uniprot id: Q9RVD9
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS09780
gene id: 243230:E5E91_RS09780
uniprot id: Q9RT22
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

243230:E5E91 RS13565
gene id: 243230:E5E91_RS13565
uniprot id: Q9RZA6
names: Cofactor
messages: Binds 1 zinc ion per subunit.

243230:E5E91 RS06720
gene id: 243230:E5E91_RS06720
uniprot id: Q9RUQ9
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

243230:E5E91 RS11800
gene id: 243230:E5E91_RS11800
uniprot id: O32508
names: Similarity
messages: Belongs to the CinA family.

243230:E5E91 RS01555
gene id: 243230:E5E91_RS01555
uniprot id: Q9RXK6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

243230:E5E91 RS13945
gene id: 243230:E5E91_RS13945
uniprot id: Q9RZ33
names: Similarity
messages: To bacterial alkanal monooxygenase alpha and beta chains.

243230:E5E91 RS09385
gene id: 243230:E5E91_RS09385
uniprot id: Q9RTA0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MraZ family.
messages: Forms oligomers.
messages: nucleoid

243230:E5E91 RS06550
gene id: 243230:E5E91_RS06550
uniprot id: Q9RUU1
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

243230:E5E91 RS03375
gene id: 243230:E5E91_RS03375
uniprot id: Q9RWL0
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS10480
gene id: 243230:E5E91_RS10480
uniprot id: Q9RSP3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
messages: Cytoplasm
messages: Homodimer.

243230:E5E91 RS10275
gene id: 243230:E5E91_RS10275
uniprot id: Q9RST0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation (Probable).
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors (Probable).

243230:E5E91 RS04555
gene id: 243230:E5E91_RS04555
uniprot id: Q9RVX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Cell membrane

243230:E5E91 RS11680
gene id: 243230:E5E91_RS11680
uniprot id: Q9RS16
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pseudouridine-5'-phosphate glycosidase family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
messages: Homotrimer.

243230:E5E91 RS11025
gene id: 243230:E5E91_RS11025
uniprot id: Q9RSD8
names: Similarity
messages: Belongs to the trans-sulfuration enzymes family.

243230:E5E91 RS15055
gene id: 243230:E5E91_RS15055
uniprot id: Q9RYG5
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

243230:E5E91 RS13150
gene id: 243230:E5E91_RS13150
uniprot id: Q9RR91
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.

243230:E5E91 RS14735
gene id: 243230:E5E91_RS14735
uniprot id: Q9RYM7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LamB/PxpA family.
messages: Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
messages: Forms a complex composed of PxpA, PxpB and PxpC.

243230:E5E91 RS06295
gene id: 243230:E5E91_RS06295
uniprot id: Q9RUZ0
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit-like subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homotrimer.
messages: May play a role in fatty acid biosynthesis.
messages: This organism lacks the other subunits that are necessary for ATP-independent citrate lyase activity. Even though this protein has clear similarity to citrate lyase beta subunit, it is expected to have a somewhat different enzyme activity.

243230:E5E91 RS15010
gene id: 243230:E5E91_RS15010
uniprot id: O32507
names: Function
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: Catalyzes the NADP(+) dependent oxidation of succinate semialdehyde to succinate.

243230:E5E91 RS08335
gene id: 243230:E5E91_RS08335
uniprot id: Q9RTU7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

243230:E5E91 RS11075
gene id: 243230:E5E91_RS11075
uniprot id: Q9RSD0
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

243230:E5E91 RS07225
gene id: 243230:E5E91_RS07225
uniprot id: Q9RUF5
names: Cofactor
names: Similarity
messages: Belongs to the GARS family.
messages: Binds 1 Mg(2+) or Mn(2+) ion per subunit.

243230:E5E91 RS03815
gene id: 243230:E5E91_RS03815
uniprot id: Q9RWC4
names: Similarity
messages: Belongs to the peptidase S1C family.

243230:E5E91 RS09345
gene id: 243230:E5E91_RS09345
uniprot id: Q9RTA9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

243230:E5E91 RS04720
gene id: 243230:E5E91_RS04720
uniprot id: Q9RVU6
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS05640
gene id: 243230:E5E91_RS05640
uniprot id: Q9RVC0
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

243230:E5E91 RS10160
gene id: 243230:E5E91_RS10160
uniprot id: Q9RSV1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

243230:E5E91 RS12435
gene id: 243230:E5E91_RS12435
uniprot id: Q9RRM7
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
messages: Homodimer.

243230:E5E91 RS01615
gene id: 243230:E5E91_RS01615
uniprot id: Q9RXJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds the 5S and 23S rRNAs and is also seen to make contacts with the A and P site tRNAs. Interacts with A site tRNA mimics, and is probably one of the key factors, along with a helix of the 23S rRNA, in positioning tRNA stems in the peptidyl-transferase center.
messages: Part of the 50S ribosomal subunit. Contacts the CTC protein (RL25).

243230:E5E91 RS06715
gene id: 243230:E5E91_RS06715
uniprot id: Q9RUR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Set transporter family.
messages: Cell membrane
messages: Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs (By similarity).

243230:E5E91 RS04710
gene id: 243230:E5E91_RS04710
uniprot id: Q9RVU8
names: Similarity
messages: Belongs to the UPF0111 family.

243230:E5E91 RS13270
gene id: 243230:E5E91_RS13270
uniprot id: Q9RR70
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
messages: There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

243230:E5E91 RS10700
gene id: 243230:E5E91_RS10700
uniprot id: Q9RSJ9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

243230:E5E91 RS00380
gene id: 243230:E5E91_RS00380
uniprot id: Q9RY77
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homohexamer.
messages: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
messages: In the N-terminal section; belongs to the CobB/CobQ family.
messages: Involved in acetate metabolism.
messages: The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site (By similarity).

243230:E5E91 RS05605
gene id: 243230:E5E91_RS05605
uniprot id: Q9RVC7
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS11930
gene id: 243230:E5E91_RS11930
uniprot id: Q9RRW9
names: Similarity
messages: Belongs to the universal stress protein A family.

243230:E5E91 RS10705
gene id: 243230:E5E91_RS10705
uniprot id: Q9RSJ8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

243230:E5E91 RS08800
gene id: 243230:E5E91_RS08800
uniprot id: Q9RTL1
names: Similarity
messages: Belongs to the peptidase C40 family.

243230:E5E91 RS05445
gene id: 243230:E5E91_RS05445
uniprot id: Q9RVF8
names: Similarity
messages: Belongs to the YciI family.

243230:E5E91 RS06875
gene id: 243230:E5E91_RS06875
uniprot id: Q9RUM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243230:E5E91 RS01470
gene id: 243230:E5E91_RS01470
uniprot id: Q9RXM1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

243230:E5E91 RS14970
gene id: 243230:E5E91_RS14970
uniprot id: Q9RYH6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

243230:E5E91 RS11920
gene id: 243230:E5E91_RS11920
uniprot id: Q9RRX1
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

243230:E5E91 RS05715
gene id: 243230:E5E91_RS05715
uniprot id: Q9RVA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm

243230:E5E91 RS12300
gene id: 243230:E5E91_RS12300
uniprot id: Q9RRQ4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the polypeptide deformylase family.
messages: Binds 1 Fe(2+) ion.
messages: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.

243230:E5E91 RS06880
gene id: 243230:E5E91_RS06880
uniprot id: Q9RUM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NlpA lipoprotein family.
messages: Membrane

243230:E5E91 RS04020
gene id: 243230:E5E91_RS04020
uniprot id: Q9RW83
names: Function
names: Similarity
messages: Belongs to the uroporphyrinogen-III synthase family.
messages: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.

243230:E5E91 RS07240
gene id: 243230:E5E91_RS07240
uniprot id: Q9RUF2
names: Function
names: Similarity
messages: Belongs to the RapZ-like family.
messages: Displays ATPase and GTPase activities.

243230:E5E91 RS04155
gene id: 243230:E5E91_RS04155
uniprot id: Q9RW55
names: Function
names: Similarity
messages: Belongs to the proline dehydrogenase family.
messages: Converts proline to delta-1-pyrroline-5-carboxylate.

243230:E5E91 RS07435
gene id: 243230:E5E91_RS07435
uniprot id: Q9RUB5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

243230:E5E91 RS04570
gene id: 243230:E5E91_RS04570
uniprot id: Q9RVX5
names: Similarity
messages: Belongs to the pseudouridine synthase RsuA family.

243230:E5E91 RS01310
gene id: 243230:E5E91_RS01310
uniprot id: Q9RXQ1
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS10300
gene id: 243230:E5E91_RS10300
uniprot id: Q9RSS5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.

243230:E5E91 RS01140
gene id: 243230:E5E91_RS01140
uniprot id: Q9RXT2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

243230:E5E91 RS12905
gene id: 243230:E5E91_RS12905
uniprot id: Q9RRD6
names: Similarity
messages: Belongs to the AfsR/DnrI/RedD regulatory family.

243230:E5E91 RS10630
gene id: 243230:E5E91_RS10630
uniprot id: Q9RSL3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity). This protein binds to the 23S rRNA, and is important in its secondary structure.
messages: Part of the 50S ribosomal subunit.

243230:E5E91 RS10820
gene id: 243230:E5E91_RS10820
uniprot id: Q9RSH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

243230:E5E91 RS03300
gene id: 243230:E5E91_RS03300
uniprot id: Q9RWM6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.

243230:E5E91 RS09520
gene id: 243230:E5E91_RS09520
uniprot id: Q9RT73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

243230:E5E91 RS08395
gene id: 243230:E5E91_RS08395
uniprot id: Q9RTT6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Monomer.

243230:E5E91 RS03930
gene id: 243230:E5E91_RS03930
uniprot id: Q9RWA1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

243230:E5E91 RS09350
gene id: 243230:E5E91_RS09350
uniprot id: Q9RTA8
names: Similarity
messages: Belongs to the OsmC/Ohr family.

243230:E5E91 RS09355
gene id: 243230:E5E91_RS09355
uniprot id: Q9RTA7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

243230:E5E91 RS14780
gene id: 243230:E5E91_RS14780
uniprot id: Q9RYL4
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS09630
gene id: 243230:E5E91_RS09630
uniprot id: Q9RT53
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

243230:E5E91 RS04005
gene id: 243230:E5E91_RS04005
uniprot id: Q9RW86
names: Similarity
messages: Belongs to the Nudix hydrolase family.

243230:E5E91 RS11120
gene id: 243230:E5E91_RS11120
uniprot id: Q9RSC2
names: Similarity
messages: Belongs to the IMPACT family.

243230:E5E91 RS13115
gene id: 243230:E5E91_RS13115
uniprot id: Q9RR97
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Affinity for substrate L-arginine is increased by TrpRS II.
messages: Belongs to the NOS family. Bacterial NOS oxygenase subfamily.
messages: Catalyzes the production of nitric oxide. The complex between TrpRS II and nitric oxide synthase oxygenase catalyzes the regioselective nitration of tryptophan at the 4-position.
messages: Homodimer. Forms a complex with trpS2; one homodimer of trpS2 binds one homodimer of nos.
messages: Nitric oxide synthase activity is increased by trpS2.
messages: This protein is similar to the oxygenase domain of eukaryotic nitric oxide synthases but lacks the reductase domain which, in eukaryotes, is responsible for transfer of electrons to the ferric heme during nitric oxide synthesis.

243230:E5E91 RS07525
gene id: 243230:E5E91_RS07525
uniprot id: Q9RU99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 4 family.
messages: Membrane

243230:E5E91 RS05270
gene id: 243230:E5E91_RS05270
uniprot id: Q9RVJ2
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS05230
gene id: 243230:E5E91_RS05230
uniprot id: Q9RVK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

243230:E5E91 RS04125
gene id: 243230:E5E91_RS04125
uniprot id: Q9RW61
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.

243230:E5E91 RS11475
gene id: 243230:E5E91_RS11475
uniprot id: Q9RS57
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

243230:E5E91 RS06810
gene id: 243230:E5E91_RS06810
uniprot id: Q9RUP1
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

243230:E5E91 RS12105
gene id: 243230:E5E91_RS12105
uniprot id: Q9RRT8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

243230:E5E91 RS01105
gene id: 243230:E5E91_RS01105
uniprot id: Q9RXT9
names: Domain
names: Subcellular Location Annotation
messages: Contains two rhodanese domains with different primary structures but with near identical secondary structure conformations suggesting a common evolutionary origin. Only the C-terminal rhodanese domain contains the catalytic cysteine residue (By similarity).
messages: Cytoplasm

243230:E5E91 RS15065
gene id: 243230:E5E91_RS15065
uniprot id: Q9RYG3
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

243230:E5E91 RS05040
gene id: 243230:E5E91_RS05040
uniprot id: Q9RVN9
names: Similarity
messages: Belongs to the Skp family.

243230:E5E91 RS08175
gene id: 243230:E5E91_RS08175
uniprot id: Q9RTX4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M3B family.
messages: Binds 1 zinc ion.
messages: Has oligopeptidase activity and degrades a variety of small bioactive peptides.

243230:E5E91 RS14565
gene id: 243230:E5E91_RS14565
uniprot id: Q9RYR1
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS06835
gene id: 243230:E5E91_RS06835
uniprot id: Q9RUN5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

243230:E5E91 RS13575
gene id: 243230:E5E91_RS13575
uniprot id: Q9RZA4
names: Function
names: PTM
names: Similarity
messages: Contains one covalently linked tetrapyrrole chromophore. Lacks the cysteine conserved in plant phytochromes (at the position of Met-259) that binds chromophore. An engineered sequence used for X-ray crystallography forms a thioether link to biliverdin through Cys-24. The natural sequence can bind phycocyanobilin and phytochromobilin in vitro, but the identity of the natural chromophore is unknown.
messages: In the N-terminal section; belongs to the phytochrome family.
messages: Photoreceptor which exists in two forms that are reversibly interconvertible by light: the R form that absorbs maximally in the red region of the spectrum and the FR form that absorbs maximally in the far-red region. Has also a slight blue shift for the far-red maximum. Could also absorb green light. May participate in regulating pigment synthesis like the carotenoid deinoxanthin which could protect the bacterium from intense visible light.

243230:E5E91 RS10710
gene id: 243230:E5E91_RS10710
uniprot id: Q9RSJ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

243230:E5E91 RS03010
gene id: 243230:E5E91_RS03010
uniprot id: Q9RWS9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ClpS family.
messages: Binds to the N-terminal domain of the chaperone ClpA.
messages: Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.

243230:E5E91 RS05860
gene id: 243230:E5E91_RS05860
uniprot id: Q9RV76
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Carboxylation allows a single lysine to coordinate two zinc ions.
messages: Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.
messages: Homotetramer.

243230:E5E91 RS12160
gene id: 243230:E5E91_RS12160
uniprot id: Q9RRS9
names: Similarity
messages: Belongs to the thioesterase PaaI family.

243230:E5E91 RS02315
gene id: 243230:E5E91_RS02315
uniprot id: Q9RX58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell membrane

243230:E5E91 RS08235
gene id: 243230:E5E91_RS08235
uniprot id: Q9RTW5
names: Similarity
messages: Belongs to the Cob(I)alamin adenosyltransferase family.

243230:E5E91 RS06545
gene id: 243230:E5E91_RS06545
uniprot id: Q9RUU2
names: Similarity
messages: Belongs to the helicase family. RecQ subfamily.

243230:E5E91 RS13145
gene id: 243230:E5E91_RS13145
uniprot id: Q9RR92
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Mg(2+). Can also accept Mn(2+).

243230:E5E91 RS09910
gene id: 243230:E5E91_RS09910
uniprot id: Q9RSZ6
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

243230:E5E91 RS10960
gene id: 243230:E5E91_RS10960
uniprot id: Q9RSE8
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS06770
gene id: 243230:E5E91_RS06770
uniprot id: Q9RUP8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

243230:E5E91 RS05625
gene id: 243230:E5E91_RS05625
uniprot id: Q9RVC3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.

243230:E5E91 RS05165
gene id: 243230:E5E91_RS05165
uniprot id: Q9RVL1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.

243230:E5E91 RS11885
gene id: 243230:E5E91_RS11885
uniprot id: Q9RRX8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

243230:E5E91 RS10410
gene id: 243230:E5E91_RS10410
uniprot id: Q9RSQ7
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

243230:E5E91 RS03235
gene id: 243230:E5E91_RS03235
uniprot id: Q9RWN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

243230:E5E91 RS07080
gene id: 243230:E5E91_RS07080
uniprot id: Q9RUI6
names: Similarity
messages: Belongs to the ComB family.

243230:E5E91 RS13555
gene id: 243230:E5E91_RS13555
uniprot id: Q9RZA8
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS04715
gene id: 243230:E5E91_RS04715
uniprot id: Q9RVU7
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS07445
gene id: 243230:E5E91_RS07445
uniprot id: Q9WXF2
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

243230:E5E91 RS07540
gene id: 243230:E5E91_RS07540
uniprot id: Q9RU96
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

243230:E5E91 RS10040
gene id: 243230:E5E91_RS10040
uniprot id: Q59337
names: Activity Regulation
names: Developmental Stage
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the catalase family.
messages: Cytoplasm
messages: Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.
messages: Homotetramer.
messages: Strongly inhibited by sodium azide and sodium cyanide, and slightly inhibited by 3-amino-1,2,4-triazole.
messages: Up-regulated during stationary phase.

243230:E5E91 RS02515
gene id: 243230:E5E91_RS02515
uniprot id: Q9RX20
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
messages: Homodimer.

243230:E5E91 RS04435
gene id: 243230:E5E91_RS04435
uniprot id: Q9RW01
names: Domain
names: Similarity
messages: Belongs to the PurH family.
messages: The IMP cyclohydrolase activity resides in the N-terminal region.

243230:E5E91 RS11570
gene id: 243230:E5E91_RS11570
uniprot id: Q9RS38
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

243230:E5E91 RS02470
gene id: 243230:E5E91_RS02470
uniprot id: Q9RX30
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Monomer.

243230:E5E91 RS01850
gene id: 243230:E5E91_RS01850
uniprot id: Q9RXE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

243230:E5E91 RS03410
gene id: 243230:E5E91_RS03410
uniprot id: Q9RWK4
names: Function
names: Similarity
messages: Belongs to the PemK/MazF family.
messages: Toxic component of a type II toxin-antitoxin (TA) system.

243230:E5E91 RS01570
gene id: 243230:E5E91_RS01570
uniprot id: Q9R342
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

243230:E5E91 RS04940
gene id: 243230:E5E91_RS04940
uniprot id: Q9RVQ2
names: Cofactor
names: Similarity
messages: Belongs to the ETF alpha-subunit/FixB family.
messages: Binds 1 FAD per dimer.

243230:E5E91 RS07620
gene id: 243230:E5E91_RS07620
uniprot id: Q9RU80
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

243230:E5E91 RS07785
gene id: 243230:E5E91_RS07785
uniprot id: Q9RU48
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Cu-Zn superoxide dismutase family.
messages: Binds 1 copper ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Lacks the last conserved histidine that binds copper.

243230:E5E91 RS05250
gene id: 243230:E5E91_RS05250
uniprot id: Q9RVJ6
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS06520
gene id: 243230:E5E91_RS06520
uniprot id: Q9RUU8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 1 family.
messages: Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

243230:E5E91 RS06260
gene id: 243230:E5E91_RS06260
uniprot id: Q9RUZ7
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Periplasm

243230:E5E91 RS08130
gene id: 243230:E5E91_RS08130
uniprot id: Q9RTY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.
messages: Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
messages: Cytoplasm
messages: Homodimer.

243230:E5E91 RS01015
gene id: 243230:E5E91_RS01015
uniprot id: Q9RXV7
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: Mutants display an increased sensitivity to oxidative stress, and a slightly increased sensitivity to ionizing radiation and UV exposure.
messages: nucleoid

243230:E5E91 RS02575
gene id: 243230:E5E91_RS02575
uniprot id: Q9RX10
names: Similarity
messages: Belongs to the 5'-nucleotidase family.

243230:E5E91 RS05540
gene id: 243230:E5E91_RS05540
uniprot id: Q9RVE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecF family.
messages: Cytoplasm
messages: The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity).

243230:E5E91 RS01010
gene id: 243230:E5E91_RS01010
uniprot id: Q9ZNA2
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

243230:E5E91 RS02490
gene id: 243230:E5E91_RS02490
uniprot id: Q9RX25
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Homotetramer.
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

243230:E5E91 RS12445
gene id: 243230:E5E91_RS12445
uniprot id: Q9RRM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

243230:E5E91 RS05525
gene id: 243230:E5E91_RS05525
uniprot id: Q9RVE3
names: Function
names: Similarity
messages: Belongs to the alanine racemase family.
messages: Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.

243230:E5E91 RS11440
gene id: 243230:E5E91_RS11440
uniprot id: Q9RS64
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: 12 di-nuclear ferroxidase centers are located at the interfaces between subunits related by 2-fold symmetry axes.
messages: Addition of Ca(2+) to dodecameric dps can result in the reduction of bound Fe(3+).
messages: Belongs to the Dps family.
messages: Dodecameric dps forms large aggregates upon binding to DNA.
messages: Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction (By similarity). Both oligomeric forms of dps exhibit ferroxidase activity and DNA binding. Dodecameric dps is capable of Fe(2+) oxidation/mineralization. Only dimeric dps affords efficient DNA protection against hydroxyl radical-mediated cleavage.
messages: The 12 subunits form a hollow sphere into which the mineral iron core of up to 500 Fe(3+) can be deposited (By similarity). The homododecameric forms at higher concentration of salt, the homodimeric form under reducing, low-salt conditions. The assembly of the dodecamer is irreversible.
messages: nucleoid

243230:E5E91 RS06620
gene id: 243230:E5E91_RS06620
uniprot id: Q9RUS8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243230:E5E91 RS00950
gene id: 243230:E5E91_RS00950
uniprot id: Q9RXW9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

243230:E5E91 RS10175
gene id: 243230:E5E91_RS10175
uniprot id: Q9RSU8
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS10365
gene id: 243230:E5E91_RS10365
uniprot id: Q9RSR7
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS13180
gene id: 243230:E5E91_RS13180
uniprot id: Q9RR86
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS00265
gene id: 243230:E5E91_RS00265
uniprot id: Q9RYA0
names: Similarity
messages: Belongs to the DinB family.

243230:E5E91 RS13030
gene id: 243230:E5E91_RS13030
uniprot id: Q9RRB4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

243230:E5E91 RS02210
gene id: 243230:E5E91_RS02210
uniprot id: Q9RX79
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS02505
gene id: 243230:E5E91_RS02505
uniprot id: Q9RX22
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the FPG family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).
messages: Monomer.

243230:E5E91 RS15650
gene id: 243230:E5E91_RS15650
uniprot id: Q9RZL8
names: Function
names: Similarity
messages: Belongs to the NrdI family.
messages: Probably involved in ribonucleotide reductase function.

243230:E5E91 RS13295
gene id: 243230:E5E91_RS13295
uniprot id: Q9RR66
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

243230:E5E91 RS13235
gene id: 243230:E5E91_RS13235
uniprot id: Q9RR77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Membrane

243230:E5E91 RS00570
gene id: 243230:E5E91_RS00570
uniprot id: Q9RY40
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

243230:E5E91 RS07520
gene id: 243230:E5E91_RS07520
uniprot id: Q9RUA0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: NDH-1 is composed of 15 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

243230:E5E91 RS07245
gene id: 243230:E5E91_RS07245
uniprot id: Q9RUF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

243230:E5E91 RS03970
gene id: 243230:E5E91_RS03970
uniprot id: Q9RW93
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Monomer.

243230:E5E91 RS11820
gene id: 243230:E5E91_RS11820
uniprot id: A0A075IPU7
names: Cofactor
names: Similarity
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.

243230:E5E91 RS00495
gene id: 243230:E5E91_RS00495
uniprot id: Q9RY55
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS08855
gene id: 243230:E5E91_RS08855
uniprot id: Q9RTK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm

243230:E5E91 RS02960
gene id: 243230:E5E91_RS02960
uniprot id: Q9RWT9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
messages: Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.
messages: Cytoplasm
messages: Homodimer.

243230:E5E91 RS10970
gene id: 243230:E5E91_RS10970
uniprot id: Q9RSE6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site (By similarity).

243230:E5E91 RS08095
gene id: 243230:E5E91_RS08095
uniprot id: Q9RTY9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

243230:E5E91 RS03065
gene id: 243230:E5E91_RS03065
uniprot id: Q9X719
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

243230:E5E91 RS00520
gene id: 243230:E5E91_RS00520
uniprot id: Q9RY50
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

243230:E5E91 RS15280
gene id: 243230:E5E91_RS15280
uniprot id: Q9RZT3
names: Similarity
messages: Belongs to the ParB family.

243230:E5E91 RS12820
gene id: 243230:E5E91_RS12820
uniprot id: Q9RRF3
names: Similarity
messages: Belongs to the DtxR/MntR family.

243230:E5E91 RS06610
gene id: 243230:E5E91_RS06610
uniprot id: Q9RUT0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
messages: Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).

243230:E5E91 RS15545
gene id: 243230:E5E91_RS15545
uniprot id: Q9RZN6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KdpC family.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

243230:E5E91 RS09785
gene id: 243230:E5E91_RS09785
uniprot id: Q9RT21
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Binds to the 50S ribosomal subunit via interactions with ribosomal protein L23. Also interacts with 23S rRNA and proteins L24 and L29 when complexed with the ribosome (PubMed:16091460, PubMed:16271892).
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity). Probably changes conformation upon binding to the ribosome (maybe in particular due to interaction with L24), exposing a hydrophobic crevice that is probably important for its chaperone activity (PubMed:16091460, PubMed:16271892).

243230:E5E91 RS06390
gene id: 243230:E5E91_RS06390
uniprot id: Q9RUX0
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

243230:E5E91 RS11805
gene id: 243230:E5E91_RS11805
uniprot id: Q7DF71
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

243230:E5E91 RS09150
gene id: 243230:E5E91_RS09150
uniprot id: Q9RTE8
names: Function
names: Similarity
messages: Belongs to the class-I DAHP synthase family.
messages: Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).

243230:E5E91 RS07715
gene id: 243230:E5E91_RS07715
uniprot id: Q9RU62
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

243230:E5E91 RS00605
gene id: 243230:E5E91_RS00605
uniprot id: Q9RY32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

243230:E5E91 RS06220
gene id: 243230:E5E91_RS06220
uniprot id: Q9RV07
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS01970
gene id: 243230:E5E91_RS01970
uniprot id: Q9RXC6
names: Similarity
messages: Belongs to the asp23 family.

243230:E5E91 RS14240
gene id: 243230:E5E91_RS14240
uniprot id: Q9RYX4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

243230:E5E91 RS12675
gene id: 243230:E5E91_RS12675
uniprot id: Q9RRI2
names: Cofactor
names: Disruption Phenotype
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YqgF nuclease family.
messages: Cytoplasm
messages: Has no RNase activity in the presence of Mg(2+), Ca(2+) or Zn(2+).
messages: Has robust sequence-specific RNase activity, acting as a 5'-3' exo/endonuclease on ssRNA substrates with minimally 3 consecutive adenine bases. Has no detectable nuclease activity on dsRNA, dsDNA or Holliday junction DNA.
messages: Monomer; also forms low amounts of dimers.
messages: Only heterozygous strains can be obtained, suggesting this gene is essential.

243230:E5E91 RS12680
gene id: 243230:E5E91_RS12680
uniprot id: Q9RRI1
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

243230:E5E91 RS15360
gene id: 243230:E5E91_RS15360
uniprot id: Q9RZR5
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS14075
gene id: 243230:E5E91_RS14075
uniprot id: Q9RZ06
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAL/histidase family.
messages: Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.
messages: Cytoplasm

243230:E5E91 RS03260
gene id: 243230:E5E91_RS03260
uniprot id: Q9RWN3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AzlC family.
messages: Membrane

243230:E5E91 RS11575
gene id: 243230:E5E91_RS11575
uniprot id: Q9RS37
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Homodimer.

243230:E5E91 RS10695
gene id: 243230:E5E91_RS10695
uniprot id: Q9RSK0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL36 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

243230:E5E91 RS11865
gene id: 243230:E5E91_RS11865
uniprot id: Q9RRY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

243230:E5E91 RS05115
gene id: 243230:E5E91_RS05115
uniprot id: Q9RVM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

243230:E5E91 RS12720
gene id: 243230:E5E91_RS12720
uniprot id: Q9RRH3
names: Activity Regulation
names: Disruption Phenotype
names: Domain
names: Function
names: Induction
names: PTM
names: Similarity
messages: Autokinase activity is stimulated by DNA damage. Stimulated by PQQ and DNA ends in vitro.
messages: Autophosphorylated.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Contains an N-terminal catalytic kinase domain and a C-terminal PQQ binding domain.
messages: Expression is induced in response to DNA damage.
messages: Mutant exhibits higher sensitivity to different DNA-damaging agents. It shows altered phosphoprotein profile and impaired DSB repair. Deletion affects expression of genes involved in intermediary metabolism, stress response and growth under stressed conditions.
messages: Plays an important role in radiation resistance and DNA double-strand break (DSB) repair. Involved in transcriptional regulation of genes important for bacterial stress response. Phosphorylates PprA in vitro.

243230:E5E91 RS01890
gene id: 243230:E5E91_RS01890
uniprot id: Q9RXE0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.
messages: Ca(+)/H(+) antiporter that extrudes calcium in exchange for external protons.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

243230:E5E91 RS01765
gene id: 243230:E5E91_RS01765
uniprot id: Q9RXG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmE/CycJ family.
messages: Cell membrane
messages: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.

243230:E5E91 RS07920
gene id: 243230:E5E91_RS07920
uniprot id: Q9RU23
names: Activity Regulation
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.

243230:E5E91 RS00785
gene id: 243230:E5E91_RS00785
uniprot id: Q9RY01
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 zinc ion.
messages: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.
messages: In the C-terminal section; belongs to the HTP reductase family.
messages: In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

243230:E5E91 RS08650
gene id: 243230:E5E91_RS08650
uniprot id: Q9RTN7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate. The apo form of AcnA functions as a RNA-binding regulatory protein.
messages: Monomer.

243230:E5E91 RS03310
gene id: 243230:E5E91_RS03310
uniprot id: Q9RWM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

243230:E5E91 RS14150
gene id: 243230:E5E91_RS14150
uniprot id: Q9RYZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsuA/YedE (TC 9.B.102) family.
messages: Cell inner membrane
messages: Membrane

243230:E5E91 RS09180
gene id: 243230:E5E91_RS09180
uniprot id: Q9RTE3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

243230:E5E91 RS10395
gene id: 243230:E5E91_RS10395
uniprot id: Q9RSR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

243230:E5E91 RS10580
gene id: 243230:E5E91_RS10580
uniprot id: Q9RSM2
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

243230:E5E91 RS02175
gene id: 243230:E5E91_RS02175
uniprot id: Q9RX85
names: Cofactor
names: Similarity
messages: Belongs to the RtcB family.
messages: Binds 2 manganese ions per subunit.

243230:E5E91 RS03460
gene id: 243230:E5E91_RS03460
uniprot id: Q9RWJ4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

243230:E5E91 RS02995
gene id: 243230:E5E91_RS02995
uniprot id: Q9RWT2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

243230:E5E91 RS01760
gene id: 243230:E5E91_RS01760
uniprot id: Q9RXG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
messages: Cell inner membrane
messages: Membrane

243230:E5E91 RS04515
gene id: 243230:E5E91_RS04515
uniprot id: Q9RVY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.
messages: Cell membrane
messages: Membrane

243230:E5E91 RS00280
gene id: 243230:E5E91_RS00280
uniprot id: Q9RY97
names: Similarity
messages: Belongs to the DinB family.

243230:E5E91 RS10075
gene id: 243230:E5E91_RS10075
uniprot id: Q9RSW6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL35 family.
messages: Binds the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Contacts proteins L15 and L33.

243230:E5E91 RS00835
gene id: 243230:E5E91_RS00835
uniprot id: Q9RXZ1
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS01605
gene id: 243230:E5E91_RS01605
uniprot id: Q9RXJ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.
messages: The globular domain of the protein is located by the polypeptide exit tunnel on the outside of the subunit while an extended beta-hairpin forms part of the wall of the tunnel. Forms a pair of 'tweezers' with L32 that hold together two different domains of the 23S rRNA. Interacts with the tunnel-blocking modified macrolide azithromycin. Upon binding of the macrolide troleadomycin to the ribosome, the tip of the beta-hairpin is displaced, which severely restricts the tunnel. This and experiments in E.coli have led to the suggestion that it is part of the gating mechanism involved in translation arrest in the absence of the protein export system.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).

243230:E5E91 RS07670
gene id: 243230:E5E91_RS07670
uniprot id: Q9RU71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

243230:E5E91 RS10600
gene id: 243230:E5E91_RS10600
uniprot id: Q9RSL8
names: Similarity
messages: Belongs to the UPF0051 (ycf24) family.

243230:E5E91 RS13355
gene id: 243230:E5E91_RS13355
uniprot id: Q9RZE4
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

243230:E5E91 RS10105
gene id: 243230:E5E91_RS10105
uniprot id: Q9RSW0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

243230:E5E91 RS08595
gene id: 243230:E5E91_RS08595
uniprot id: Q9RTP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Cell membrane
messages: H(+)-stimulated, divalent metal cation uptake system.

243230:E5E91 RS16075
gene id: 243230:E5E91_RS16075
uniprot id: Q9RXL8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

243230:E5E91 RS00910
gene id: 243230:E5E91_RS00910
uniprot id: Q9RXX7
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

243230:E5E91 RS01955
gene id: 243230:E5E91_RS01955
uniprot id: Q9RXC9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

243230:E5E91 RS14315
gene id: 243230:E5E91_RS14315
uniprot id: Q9RYW0
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

243230:E5E91 RS03270
gene id: 243230:E5E91_RS03270
uniprot id: Q9RWN1
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.

243230:E5E91 RS04650
gene id: 243230:E5E91_RS04650
uniprot id: Q9RVV9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

243230:E5E91 RS06800
gene id: 243230:E5E91_RS06800
uniprot id: Q9RUP3
names: Similarity
messages: Belongs to the bleomycin resistance protein family.

243230:E5E91 RS01075
gene id: 243230:E5E91_RS01075
uniprot id: Q9RXU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

243230:E5E91 RS09110
gene id: 243230:E5E91_RS09110
uniprot id: Q9RTF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GcvP family.
messages: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

243230:E5E91 RS10280
gene id: 243230:E5E91_RS10280
uniprot id: Q9RSS9
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Part of the 50S ribosomal subunit.

243230:E5E91 RS03115
gene id: 243230:E5E91_RS03115
uniprot id: Q9RWR0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

243230:E5E91 RS14680
gene id: 243230:E5E91_RS14680
uniprot id: Q9RYN8
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

243230:E5E91 RS11425
gene id: 243230:E5E91_RS11425
uniprot id: Q9RS67
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

243230:E5E91 RS13315
gene id: 243230:E5E91_RS13315
uniprot id: Q9RR62
names: Similarity
messages: Belongs to the pyruvate kinase family.

243230:E5E91 RS05015
gene id: 243230:E5E91_RS05015
uniprot id: Q9RVP2
names: Function
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
messages: tRNA nucleotidyltransferase involved in the synthesis of the tRNA CCA terminus. Adds the two cytidine residues to tRNA.

243230:E5E91 RS03510
gene id: 243230:E5E91_RS03510
uniprot id: Q9RWI4
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

243230:E5E91 RS04290
gene id: 243230:E5E91_RS04290
uniprot id: Q9RW29
names: Similarity
messages: In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

243230:E5E91 RS12755
gene id: 243230:E5E91_RS12755
uniprot id: Q9RRG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Cell membrane
messages: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate across the membrane.

243230:E5E91 RS04255
gene id: 243230:E5E91_RS04255
uniprot id: Q9RW36
names: Similarity
messages: Belongs to the histone deacetylase family.

243230:E5E91 RS11765
gene id: 243230:E5E91_RS11765
uniprot id: Q9RRZ8
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. YfcE family.

243230:E5E91 RS15370
gene id: 243230:E5E91_RS15370
uniprot id: Q9RZR3
names: Function
messages: Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.

243230:E5E91 RS07290
gene id: 243230:E5E91_RS07290
uniprot id: Q9RUE3
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.
messages: Cytoplasm
messages: Heteromultimer composed of HisG and HisZ subunits.
messages: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity).
messages: This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.

243230:E5E91 RS00945
gene id: 243230:E5E91_RS00945
uniprot id: Q9RXX0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

243230:E5E91 RS10690
gene id: 243230:E5E91_RS10690
uniprot id: Q9RSK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

243230:E5E91 RS14855
gene id: 243230:E5E91_RS14855
uniprot id: Q9RYJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UreE family.
messages: Cytoplasm
messages: Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.

243230:E5E91 RS03605
gene id: 243230:E5E91_RS03605
uniprot id: Q9RWG7
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.

243230:E5E91 RS09775
gene id: 243230:E5E91_RS09775
uniprot id: Q9RT23
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

243230:E5E91 RS06710
gene id: 243230:E5E91_RS06710
uniprot id: Q9RUR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

243230:E5E91 RS03845
gene id: 243230:E5E91_RS03845
uniprot id: Q9RWB8
names: Function
names: Similarity
messages: Belongs to the MinE family.
messages: Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity).

243230:E5E91 RS01770
gene id: 243230:E5E91_RS01770
uniprot id: Q9RXG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CcmC/CycZ/HelC family.
messages: Membrane

243230:E5E91 RS00450
gene id: 243230:E5E91_RS00450
uniprot id: Q9RY64
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Binds directly to 23S rRNA, probably serving to organize its structure.
messages: Part of the 50S ribosomal subunit. Contacts proteins L15 and L20.

243230:E5E91 RS15460
gene id: 243230:E5E91_RS15460
uniprot id: Q9RZQ1
names: Similarity
messages: Belongs to the peptidase S8 family.

243230:E5E91 RS08445
gene id: 243230:E5E91_RS08445
uniprot id: Q9RTS6
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.

243230:E5E91 RS03120
gene id: 243230:E5E91_RS03120
uniprot id: Q9RWQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

243230:E5E91 RS13265
gene id: 243230:E5E91_RS13265
uniprot id: Q9RR71
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

243230:E5E91 RS04500
gene id: 243230:E5E91_RS04500
uniprot id: Q9RVY8
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS12865
gene id: 243230:E5E91_RS12865
uniprot id: Q9RRE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

243230:E5E91 RS07600
gene id: 243230:E5E91_RS07600
uniprot id: Q9RU84
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).

243230:E5E91 RS14875
gene id: 243230:E5E91_RS14875
uniprot id: Q9RYJ4
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.
messages: Binds 2 nickel ions per subunit.
messages: Carboxylation allows a single lysine to coordinate two nickel ions.
messages: Cytoplasm
messages: Heterohexamer of 3 UreC (alpha) and 3 UreAB (gamma/beta) subunits.

243230:E5E91 RS04035
gene id: 243230:E5E91_RS04035
uniprot id: Q9RW80
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

243230:E5E91 RS07560
gene id: 243230:E5E91_RS07560
uniprot id: Q9RU92
names: Function
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

243230:E5E91 RS10660
gene id: 243230:E5E91_RS10660
uniprot id: Q9RSK7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.

243230:E5E91 RS13950
gene id: 243230:E5E91_RS13950
uniprot id: Q9RZ32
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

243230:E5E91 RS06370
gene id: 243230:E5E91_RS06370
uniprot id: Q9RUX5
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

243230:E5E91 RS05120
gene id: 243230:E5E91_RS05120
uniprot id: Q9RVM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

243230:E5E91 RS06555
gene id: 243230:E5E91_RS06555
uniprot id: Q9RUU0
names: Function
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.

243230:E5E91 RS07250
gene id: 243230:E5E91_RS07250
uniprot id: Q9RUF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

243230:E5E91 RS03205
gene id: 243230:E5E91_RS03205
uniprot id: Q9RWP3
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

243230:E5E91 RS11710
gene id: 243230:E5E91_RS11710
uniprot id: Q9RS10
names: Similarity
messages: Belongs to the shaker potassium channel beta subunit family.

243230:E5E91 RS03800
gene id: 243230:E5E91_RS03800
uniprot id: Q9RWC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

243230:E5E91 RS12155
gene id: 243230:E5E91_RS12155
uniprot id: Q9RRT0
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

243230:E5E91 RS10825
gene id: 243230:E5E91_RS10825
uniprot id: Q9RSH3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

243230:E5E91 RS02350
gene id: 243230:E5E91_RS02350
uniprot id: Q9RX54
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

243230:E5E91 RS02845
gene id: 243230:E5E91_RS02845
uniprot id: Q9RWV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.

243230:E5E91 RS11545
gene id: 243230:E5E91_RS11545
uniprot id: Q9RS42
names: Similarity
messages: Belongs to the Nth/MutY family.

243230:E5E91 RS05245
gene id: 243230:E5E91_RS05245
uniprot id: Q9RVJ7
names: Similarity
messages: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

243230:E5E91 RS00550
gene id: 243230:E5E91_RS00550
uniprot id: Q9RY44
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
messages: Cell membrane
messages: Multidrug efflux pump.

243230:E5E91 RS12190
gene id: 243230:E5E91_RS12190
uniprot id: Q9RRS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.
messages: Membrane

243230:E5E91 RS07580
gene id: 243230:E5E91_RS07580
uniprot id: Q9RU88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 30 kDa subunit family.
messages: Cell membrane
messages: NDH-1 is composed of 15 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

243230:E5E91 RS10965
gene id: 243230:E5E91_RS10965
uniprot id: Q9RSE7
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

243230:E5E91 RS09580
gene id: 243230:E5E91_RS09580
uniprot id: Q9RT62
names: Function
messages: May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.

243230:E5E91 RS14605
gene id: 243230:E5E91_RS14605
uniprot id: Q9RYQ3
names: Function
names: Similarity
messages: Belongs to the phenylacetyl-CoA ligase family.
messages: Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).

243230:E5E91 RS14860
gene id: 243230:E5E91_RS14860
uniprot id: Q9RYJ7
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.

243230:E5E91 RS02160
gene id: 243230:E5E91_RS02160
uniprot id: Q9RX88
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit. Contacts proteins L11 and L16, the A site tRNA, and the 5S and 23S rRNAs.
messages: This is one of 3 proteins that mediate the attachment of the 5S rRNA onto the large ribosomal subunit. This protein has three domains. The N-terminal one is bound on the solvent face, the middle domain fills the space between the 5S rRNA and the L11 arm contacting the 23S rRNA while the C-terminal domain is on the edge of the intersubunit interface and contacts the A site. The protein conformation changes upon binding of a tRNA mimic to the A site, although the mimic does not interact directly with CTC itself, consistent with CTCs presumed role in moderating A site binding.

243230:E5E91 RS12965
gene id: 243230:E5E91_RS12965
uniprot id: Q9RRC4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

243230:E5E91 RS14845
gene id: 243230:E5E91_RS14845
uniprot id: Q9RYK0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.
messages: Cytoplasm
messages: Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
messages: Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

243230:E5E91 RS14560
gene id: 243230:E5E91_RS14560
uniprot id: Q9RYR2
names: Similarity
messages: Belongs to the bacterial solute-binding protein 5 family.

243230:E5E91 RS05765
gene id: 243230:E5E91_RS05765
uniprot id: Q9RV96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.

243230:E5E91 RS00625
gene id: 243230:E5E91_RS00625
uniprot id: Q9RY28
names: Similarity
messages: Belongs to the TrpF family.

243230:E5E91 RS01625
gene id: 243230:E5E91_RS01625
uniprot id: Q9RXJ3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

243230:E5E91 RS01475
gene id: 243230:E5E91_RS01475
uniprot id: Q9RXM0
names: Subcellular Location Annotation
messages: Membrane

243230:E5E91 RS10715
gene id: 243230:E5E91_RS10715
uniprot id: Q9RSJ6
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

243230:E5E91 RS09790
gene id: 243230:E5E91_RS09790
uniprot id: Q9RT20
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

243230:E5E91 RS15530
gene id: 243230:E5E91_RS15530
uniprot id: Q9RZP0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.
messages: Cell membrane
messages: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.
messages: The system is composed of three essential subunits: KdpA, KdpB and KdpC.

243230:E5E91 RS10720
gene id: 243230:E5E91_RS10720
uniprot id: Q9RSJ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Contacts proteins L3 and L32.

243230:E5E91 RS01835
gene id: 243230:E5E91_RS01835
uniprot id: Q9RXF1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-alanine--D-alanine ligase family.
messages: Binds 2 magnesium or manganese ions per subunit.
messages: Cell wall formation.
messages: Cytoplasm

243230:E5E91 RS15210
gene id: 243230:E5E91_RS15210
uniprot id: Q9RZU5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ABC transporter superfamily. Heme (hemin) importer (TC 3.A.1.14.5) family.
messages: Cell membrane
messages: Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system.
messages: The complex is composed of two ATP-binding proteins (HmuV), two transmembrane proteins (HmuU) and a solute-binding protein (HmuT).

243230:E5E91 RS14840
gene id: 243230:E5E91_RS14840
uniprot id: Q9RYK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UreD family.
messages: Cytoplasm
messages: Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
messages: UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.

243230:E5E91 RS10535
gene id: 243230:E5E91_RS10535
uniprot id: Q9RSN1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane
messages: Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents.

243230:E5E91 RS01550
gene id: 243230:E5E91_RS01550
uniprot id: Q9RXK7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

243230:E5E91 RS08810
gene id: 243230:E5E91_RS08810
uniprot id: Q9RTK9
names: Similarity
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.

243230:E5E91 RS05130
gene id: 243230:E5E91_RS05130
uniprot id: Q9RVM0
names: Similarity
messages: Belongs to the Nudix hydrolase family.

243230:E5E91 RS06485
gene id: 243230:E5E91_RS06485
uniprot id: Q9RUV5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

243230:E5E91 RS02890
gene id: 243230:E5E91_RS02890
uniprot id: Q9RWV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

243230:E5E91 RS04965
gene id: 243230:E5E91_RS04965
uniprot id: Q9RVP7
names: Similarity
messages: Belongs to the Nudix hydrolase family.

243230:E5E91 RS08030
gene id: 243230:E5E91_RS08030
uniprot id: Q9RU01
names: Function
names: Similarity
messages: Belongs to the glucose-6-phosphate dehydrogenase family.
messages: Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.

243230:E5E91 RS04860
gene id: 243230:E5E91_RS04860
uniprot id: Q9RVR8
names: Cofactor
names: Similarity
messages: Belongs to the cytochrome b560 family.
messages: The heme is bound between the two transmembrane subunits.

243230:E5E91 RS14880
gene id: 243230:E5E91_RS14880
uniprot id: Q9RYJ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterohexamer of 3 UreC (alpha) and 3 UreAB (gamma/beta) subunits.
messages: In the C-terminal section; belongs to the urease beta subunit family.
messages: In the N-terminal section; belongs to the urease gamma subunit family.

243230:E5E91 RS04915
gene id: 243230:E5E91_RS04915
uniprot id: Q9RVQ7
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

243230:E5E91 RS09375
gene id: 243230:E5E91_RS09375
uniprot id: Q9RTA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Cell membrane
messages: Membrane